CN104622820A - Freeze-drying method for animal medicines - Google Patents
Freeze-drying method for animal medicines Download PDFInfo
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- CN104622820A CN104622820A CN201510096241.5A CN201510096241A CN104622820A CN 104622820 A CN104622820 A CN 104622820A CN 201510096241 A CN201510096241 A CN 201510096241A CN 104622820 A CN104622820 A CN 104622820A
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Abstract
The invention discloses a freeze-drying method for animal medicines. The milk is added for freeze-drying, wherein the amount of the milk is 1-5 times that of the weight of fresh animal medicines. The prepared animal medicines are easy to grind and small in oral odor.
Description
Invention field
The present invention relates to medicine method for making, particularly a kind of freeze drying process of animal drug, belong to medical art.
Background technology
Animal drugs is the important component part of pools of traditional Chinese medicine, the advantage of himself is had compared with plant amedica, mineral drug, as strong in active ingredient effect, using dosage is little, evident in efficacy and single-minded, its toxic and side effects is low in addition, medicament sources and use are extensively, the masses to gathering medicinal herbs, medication has rich experience, makes it deeply by the attention of medical circle and the people.But many medical material abnormal flavour are extra heavy, and mouthfeel is very poor.Over the past thousands of years, people always encourage patient medication with " good medicine tastes bitter ".But the reality of society is, people hang back in face of the good medicine of " hardship " mouth, even talk " hardship " complexion changed.Have a strong impact on the application of animal drug.。
In order to improve curative effect, strong raw meat is rectified and is smelt, and successive dynasties medical literature is recorded more to the concocting method of animal drugs medical material, divides and has clean system, cutting, add adjuvant and do not add several large class of adjuvant system, tens kinds of concocting methods, as roasting, oil system, vinegar system, processed with wine etc.Although these concocting methods are rectified to smell to strong raw meat certain effect, abnormal flavour is still heavier.
Vacuum lyophilization, also known as lyophilizing, can preserve the activity of effective medicinal components to greatest extent, but lyophilizing animal drug still abnormal flavour is heavier, mouthfeel is still very poor, and patient still not easily accepts.
Summary of the invention
The object of this invention is to provide a kind of lyophilizing side of animal drug
method, make that the animal drug of lyophilizing is easily pulverized, fishy smell is little.
Object of the present invention is achieved through the following technical solutions:
A freeze drying process for animal drug, is characterized in that: add milk lyophilizing.
The freeze drying process of a kind of animal drug of the present invention, is characterized in that: milk consumption is 1-5 times of fresh animal drug by weight.
The freeze drying process of a kind of animal drug of the present invention, is characterized in that: lyophilizing is refrigerated to less than-10 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation controls below 45 DEG C, and resolution temperature controls below 50 DEG C, to dry.
The freeze drying process of a kind of animal drug of the present invention, is characterized in that: for the lyophilizing of Hirudo, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, Agkistrodon.
Animal drug prepared by the present invention is easily pulverized, abnormal flavour is little.
Below by embodiment, usefulness of the present invention is described.Embodiment is intended to further illustrate beneficial effect of the present invention, but not restriction of the present invention.
Detailed description of the invention
embodiment 1
The animal drug mouthfeel of distinct methods drying compares
1, by each fresh animal drug different types of, after clean system, lyophilizing by the following method respectively.
1) dry;
2) lyophilizing: put in freeze dryer, be refrigerated to-20 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and sublimation temperature controls at 40 DEG C, and resolution temperature controls at 45 DEG C, to dry;
3) lyophilizing with milk: the milk adding 1 times by weight, puts in freeze dryer, is refrigerated to-20 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and sublimation temperature controls at 40 DEG C, and resolution temperature controls at 45 DEG C, to dry.
2, each animal drug mouthfeel of distinct methods drying compares
Each animal drug getting distinct methods drying is respectively pulverized, mix well with warm water, be made up of 10 people and appraise group through discussion, everyone takes each animal drug product powder of distinct methods drying respectively, enters to evaluate to the concept such as mouthfeel " free from extraneous odour ", " rare abnormal flavour ", " abnormal flavour is heavier ", " abnormal flavour is very heavy ".The results are shown in Table 1.
Each animal drugs powder mouthfeel comparative result of table 1 distinct methods drying
| Free from extraneous odour | Rare abnormal flavour | Abnormal flavour is heavier | Abnormal flavour is very heavy | |
| Lyophilizing Hirudo with milk | 1 people | 3 people | 6 people | 0 people |
| Lyophilizing Hirudo | 0 people | 0 people | 2 people | 8 people |
| Dry Hirudo | 0 people | 0 people | 0 people | 10 people |
| Lyophilizing Eupolyphaga Seu Steleophaga with milk | 3 people | 6 people | 1 people | 0 people |
| Lyophilizing Eupolyphaga Seu Steleophaga | 0 people | 0 people | 3 people | 7 people |
| Dry Eupolyphaga Seu Steleophaga | 0 people | 0 people | 1 people | 9 people |
| Lyophilizing Pheretima with milk | 1 people | 2 people | 7 people | 0 people |
| Lyophilizing Pheretima | 0 people | 0 people | 3 people | 7 people |
| Dry Pheretima | 0 people | 0 people | 0 people | 10 people |
| Lyophilizing Gekko Swinhonis with milk | 0 people | 2 people | 8 people | 0 people |
| Lyophilizing Gekko Swinhonis | 0 people | 0 people | 0 people | 10 people |
| Dry Gekko Swinhonis | 0 people | 0 people | 0 people | 10 people |
| Lyophilizing Penis et testis cervi with milk | 0 people | 3 people | 7 people | 0 people |
| Lyophilizing Penis et testis cervi | 0 people | 0 people | 5 people | 5 people |
| Dry Penis et testis cervi | 0 people | 0 people | 2 people | 8 people |
| Lyophilizing Testis Et penis Caprae seu Ovis with milk | 0 people | 3 people | 5 people | 2 people |
| Lyophilizing Testis Et penis Caprae seu Ovis | 0 people | 0 people | 0 people | 10 people |
| Dry Testis Et penis Caprae seu Ovis | 0 people | 0 people | 0 people | 10 people |
| Lyophilizing Testis et penis callorhini with milk | 0 people | 1 people | 5 people | 4 people |
| Lyophilizing Testis et penis callorhini | 0 people | 0 people | 3 people | 7 people |
| Dry Testis et penis callorhini | 0 people | 0 people | 0 people | 10 people |
| Lyophilizing Air Bladder pseudosciaenae seu Acipenser with milk | 1 people | 7 people | 2 people | 0 people |
| Lyophilizing Air Bladder pseudosciaenae seu Acipenser | 0 people | 3 people | 3 people | 4 people |
| Dry Air Bladder pseudosciaenae seu Acipenser | 0 people | 0 people | 1 people | 9 people |
| Lyophilizing Hippocampus with milk | 0 people | 5 people | 5 people | 0 people |
| Lyophilizing Hippocampus | 0 people | 0 people | 5 people | 5 people |
| Dry Hippocampus | 0 people | 0 people | 0 people | 10 people |
| Lyophilizing Blatta seu periplaneta with milk | 1 people | 3 people | 6 people | 0 people |
| Lyophilizing Blatta seu periplaneta | 0 people | 0 people | 6 people | 4 people |
| Dry Blatta seu periplaneta | 0 people | 0 people | 0 people | 10 people |
| Lyophilizing Scorpio with milk | 3 people | 7 people | 0 people | 0 people |
| Lyophilizing Scorpio | 0 people | 9 people | 1 people | 0 people |
| Dry Scorpio | 0 people | 1 people | 9 people | 0 people |
| Freezed dried centipede with milk | 2 people | 6 people | 4 people | 0 people |
| Freezed dried centipede | 0 people | 5 people | 5 people | 0 people |
| Dry Scolopendra | 0 people | 0 people | 7 people | 3 people |
| Lyophilizing Bungarus Parvus with milk | 1 people | 9 people | 0 people | 0 people |
| Lyophilizing Bungarus Parvus | 0 people | 4 people | 6 people | 0 people |
| Dry Bungarus Parvus | 0 people | 0 people | 5 people | 5 people |
| Lyophilizing Agkistrodon with milk | 1 people | 9 people | 0 people | 0 people |
| Lyophilizing Agkistrodon | 0 people | 4 people | 6 people | 0 people |
| Dry Agkistrodon | 0 people | 0 people | 5 people | 5 people |
Result shows, and the oral abnormal flavour of lyophilizing animal drug with milk is little, and mouthfeel is good.
embodiment 2
Each animal drug flour extraction of distinct methods drying compares
1, by each fresh animal drug different types of, after clean system, lyophilizing by the following method respectively.
1) dry;
2) lyophilizing: put in freeze dryer, be refrigerated to-32 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and sublimation temperature controls at 45 DEG C, and resolution temperature controls at 50 DEG C, to dry;
3) lyophilizing with milk: the milk adding 5 times by weight, puts in freeze dryer, is refrigerated to-20 DEG C, is evacuated to drying chamber pressure 45Pa, subliming by heating, and sublimation temperature controls at 40 DEG C, and resolution temperature controls at 45 DEG C, to dry.
2, each animal drug flour extraction of distinct methods drying compares
Get each animal drug 100g of distinct methods drying respectively, put in use for laboratory Universalpulverizer, pulverize 5min, took out 80 mesh sieves, by the powder weighing of sieve, calculate flour extraction, flour extraction (%)=amount to into sterling by the medical material of the heavy ÷ gross weight × 100%(of the powder lyophilizing with milk of sieve to calculate).The results are shown in Table 2.
Each animal drug flour extraction result of table 2 distinct methods drying
| Lyophilizing flour extraction with milk | Lyophilizing flour extraction | Dry flour extraction | |
| Hirudo | 94.6 | 93.7 | 65.8 |
| Eupolyphaga Seu Steleophaga | 98.4 | 97.0 | 78.1 |
| Pheretima | 92.3 | 91.2 | 61.9 |
| Gekko Swinhonis | 87.6 | 81.4 | 47.8 |
| Penis et testis cervi | 78.7 | 71.4 | 42.7 |
| Testis Et penis Caprae seu Ovis | 81.6 | 79.6 | 52.3 |
| Testis et penis callorhini | 84.7 | 80.2 | 51.4 |
| Air Bladder pseudosciaenae seu Acipenser | 97.9 | 91.7 | 82.5 |
| Hippocampus | 89.8 | 89.0 | 75.4 |
| Blatta seu periplaneta | 95.5 | 95.5 | 89.2 |
| Scorpio | 94.8 | 95.1 | 72.4 |
| Scolopendra | 95.7 | 93.2 | 80.5 |
| Bungarus Parvus | 88.4 | 88.0 | 67.5 |
| Agkistrodon | 88.9 | 85.6 | 64.7 |
Result shows, and the animal drug powder process rate of lyophilizing and lyophilizing with milk is suitable, all apparently higher than the animal drug dried, illustrates that the animal drug of lyophilizing and lyophilizing with milk is easy to pulverize.
embodiment 3
Get fresh Hirudo, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, each 5kg of Agkistrodon, add 5kg milk respectively, put in freeze dryer, be refrigerated to-10 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls at 45 DEG C, resolution temperature controls at 50 DEG C, to dry.Obtain free from extraneous odour, the solid carbon dioxide trematodiasis of easily pulverizing, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, Agkistrodon respectively.
embodiment 4
Get fresh Hirudo, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, each 5kg of Agkistrodon, add 25kg milk respectively, put in freeze dryer, be refrigerated to-28 DEG C, be evacuated to drying chamber pressure 40Pa, subliming by heating, the temperature of distillation controls at 40 DEG C, resolution temperature controls at 45 DEG C, to dry.Obtain free from extraneous odour, the solid carbon dioxide trematodiasis of easily pulverizing, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, Agkistrodon.
embodiment 5
Get fresh Hirudo, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, each 5kg of Agkistrodon, add 15kg milk respectively, put in freeze dryer, be refrigerated to-32 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation controls at 30 DEG C, resolution temperature controls at 30 DEG C, to dry.Obtain free from extraneous odour, the solid carbon dioxide trematodiasis of easily pulverizing, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, Agkistrodon.
embodiment 6
Get fresh Hirudo, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, each 5kg of Agkistrodon, add 7kg milk respectively, put in freeze dryer, be refrigerated to-20 DEG C, be evacuated to drying chamber pressure 50Pa, subliming by heating, the temperature of distillation controls at 25 DEG C, resolution temperature controls at 45 DEG C, to dry.Obtain free from extraneous odour, the solid carbon dioxide trematodiasis of easily pulverizing, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, Agkistrodon.
Claims (4)
1. a freeze drying process for animal drug, is characterized in that: add milk lyophilizing.
2. the freeze drying process of a kind of animal drug according to claim 1, is characterized in that: milk consumption is 1-5 times of fresh animal drug by weight.
3. the freeze drying process of a kind of animal drug according to claim 1, is characterized in that: lyophilizing is refrigerated to less than-10 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating; The temperature of distillation controls below 45 DEG C, and resolution temperature controls below 50 DEG C, to dry.
4. the freeze drying process of a kind of animal drug according to claim 1, is characterized in that: for the lyophilizing of Hirudo, Eupolyphaga Seu Steleophaga, Pheretima, Gekko Swinhonis, Penis et testis cervi, Testis Et penis Caprae seu Ovis, Testis et penis callorhini, Air Bladder pseudosciaenae seu Acipenser, Hippocampus, Scorpio, Scolopendra, Bungarus Parvus, Agkistrodon.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510096241.5A CN104622820A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method for animal medicines |
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| CN201510096241.5A CN104622820A (en) | 2015-03-05 | 2015-03-05 | Freeze-drying method for animal medicines |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983743A (en) * | 2015-06-19 | 2015-10-21 | 广西复鑫益生物科技有限公司平南分公司 | Dried leech product processing method |
| CN106616435A (en) * | 2016-12-06 | 2017-05-10 | 贾玉山 | Five-toxin yak, and yak meat and yak meat soup thereof |
| CN108813574A (en) * | 2018-04-26 | 2018-11-16 | 陆川县海兰养殖专业合作社 | The processing method of golden head centipede |
| CN109758480A (en) * | 2019-03-27 | 2019-05-17 | 景德镇陈锋特种野生动物科技开发有限公司 | A kind of production method of the long-noded pit viper freeze-dried powder for rheumatoid arthritis |
-
2015
- 2015-03-05 CN CN201510096241.5A patent/CN104622820A/en active Pending
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| 张淑贞等: "中药炮制浅谈", 《河南中医药学刊》 * |
| 曲婷等: "产地加工和炮制对蟾酥药材及饮片质量的影响", 《中国实验方剂学杂志》 * |
| 王志巍等: "蟾酥的炮制方法探讨", 《中医药学报》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983743A (en) * | 2015-06-19 | 2015-10-21 | 广西复鑫益生物科技有限公司平南分公司 | Dried leech product processing method |
| CN106616435A (en) * | 2016-12-06 | 2017-05-10 | 贾玉山 | Five-toxin yak, and yak meat and yak meat soup thereof |
| CN108813574A (en) * | 2018-04-26 | 2018-11-16 | 陆川县海兰养殖专业合作社 | The processing method of golden head centipede |
| CN109758480A (en) * | 2019-03-27 | 2019-05-17 | 景德镇陈锋特种野生动物科技开发有限公司 | A kind of production method of the long-noded pit viper freeze-dried powder for rheumatoid arthritis |
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