CN104623546A - Pharmaceutical composition for treating proliferation of mammary gland - Google Patents
Pharmaceutical composition for treating proliferation of mammary gland Download PDFInfo
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- CN104623546A CN104623546A CN201510062965.8A CN201510062965A CN104623546A CN 104623546 A CN104623546 A CN 104623546A CN 201510062965 A CN201510062965 A CN 201510062965A CN 104623546 A CN104623546 A CN 104623546A
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Abstract
The invention provides a pharmaceutical composition for treating proliferation of mammary gland. The pharmaceutical composition is characterized by comprising the following components in parts by weight: 20-50 parts of selfheal, 20-50 parts of radix scrophulariae, 20-50 parts of raw oyster, 10-20 parts of kelp, 10-18 parts of seaweed, 5-15 parts of pericarpium citri reticulatae viride, 5-15 parts of pericarpium citri reticulatae, 1-10 parts of rhizoma sparganii and 1-10 parts of curcuma zedoary. The pharmaceutical composition preparation is composed of a traditional Chinese medicine composition and a pharmaceutically acceptable carrier, the dosage form comprises decoction, pills, capsules, granules, electuary and oral liquid. The composition provided by the invention has the functions of nourishing yin and clearing heat, reducing phlegm and resolving masses, and promoting the circulation of qi and breaking stasis.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition for the treatment of cyclomastopathy.
Background technology
Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, often shows as distending pain of the breast and lump in breast, and pain is common is one-sided or bilateral distending pain of the breast or tenderness, periodically pain, and premenstrua occurs or increases the weight of.Be mainly in 20-50 year women, onset peak is 35-40 year.The treatment of current cyclomastopathy, mainly based on operative therapy, is generally not easily accepted by patient.The medicine for the treatment of cyclomastopathy also has multiple, conventional Western medicine has hormone antagonist class drug tamoxifen, male sex hormone drug third testis or methyl testosterone and prolactin antagonist medicine, though these medicines have certain curative effect, but the cycle of taking is long, easy recurrence, very easily cause iatrogenic injury, side effect is comparatively large, unsuitable long-term taking.Cyclomastopathy belongs to the traditional Chinese medical science " nodules of the breast " category, and the traditional Chinese medical science thinks that nodules of the breast is the stagnation of QI due to depression of the liver because a variety of causes causes, liver controlling conveyance and dispersion, depression of liver-QI, functional activity of QI being not smooth, and blood is obstructed, and produces the stasis of blood stagnant, or Chong and Ren channel disorder, incoordination between the liver and spleen.General treatment oral hard masses softening and resolving class medicine or Chinese patent medicine, cure the symptoms, not the disease, and do not reach the object for the treatment of.Mammary gland is the target organ of multiple endocrine organ, easily by the impact of mental emotion, according to " soothing the stagnant liver ", the principle of " disease caused by accumulations of pathogen should be treated with therapy of dispersion ", utilizes pharmaceutical composition nourishing YIN and clearing away heat of the present invention, dissipating phlegm and resolving masses, circulation of qi promoting removing blood stasis with potent drugs carries out dialectical treating, then takes psychological counseling, adjustment rule of life, strikes a proper balance between work and rest, low fat diets etc. are conducive to setting up live and work order that is happy, rule, can reach effect for the treatment of both the principal and secondary aspects of a disease to cyclomastopathy.Summary of the invention
The present invention aims to provide a kind of pharmaceutical composition for the treatment of cyclomastopathy.
For achieving the above object, a kind of pharmaceutical composition for the treatment of cyclomastopathy of the present invention, its concrete scheme is:
A kind of pharmaceutical composition for the treatment of cyclomastopathy of the present invention, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Spica Prunellae 20-50 part, Radix Scrophulariae 20-50 part, Concha Ostreae 20-50 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Sargassum 10-18 part, Pericarpium Citri Reticulatae Viride 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Sparganii 1-10 part, Rhizoma Curcumae 1-10 part.
A kind of pharmaceutical composition for the treatment of cyclomastopathy of the present invention, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Spica Prunellae 25-45 part, Radix Scrophulariae 25-45 part, Concha Ostreae 25-45 part, Thallus Laminariae (Thallus Eckloniae) 12-18 part, Sargassum 10-15 part, Pericarpium Citri Reticulatae Viride 6-12 part, Pericarpium Citri Reticulatae 6-12 part, Rhizoma Sparganii 3-9 part, Rhizoma Curcumae 3-9 part.
The pharmaceutical composition of a kind of cyclomastopathy of the present invention, is characterized in that these pharmaceutical composition parts by weight are counted: Spica Prunellae 30 parts, Radix Scrophulariae 30 parts, Concha Ostreae 30 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Sargassum 12 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae 9 parts, Rhizoma Sparganii 6 parts, Rhizoma Curcumae 6 parts.
The preparation of the Chinese medicine composition described in any one of the present invention, is characterized in that, described preparation is capsule preparations.Preparation of the present invention, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.Preparation of the present invention, is characterized in that, described preparation is capsule.
Preparation of the present invention, is characterized in that, the preparation method of described water decoction is:
1) get recipe quantity Spica Prunellae, Radix Scrophulariae, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Rhizoma Sparganii, Rhizoma Curcumae, mixing, dry, grind;
2) water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste;
3) add the adjuvant of proper proportion in thick paste, stir, obtained soft material;
4) cross 10 mesh sieves, obtain wet granular;
5) 50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.Preparation of the present invention, is characterized in that, the adjuvant of preparing of described capsule is: one or more combinations in sucrose, lactose, mannitol, aspartame, stevioside, dextrin, soluble starch, sodium carboxymethyl cellulose, polyvidone.The application of Chinese medicine composition described in any one of the present invention in preparation treatment cyclomastopathy medicine.The each component pharmacology analysis of prescription of the present invention:
Spica Prunellae is pungent, bitter, cold.Return liver, gallbladder meridian.Purging liver-fire, improving eyesight, mass dissipating and swelling eliminating.
Radix Scrophulariae, sweet, bitter, salty, be slightly cold.Return spleen, stomach, kidney channel.Clearing away heat and cooling blood; Nourishing YIN to lower pathogenic fire; Detoxicating and resolving stagnation of pathogens.
Concha Ostreae, salty, be slightly cold.Return liver, gallbladder, kidney channel.Suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.There is YIN nourishing, nourish blood, tonifying five ZANG-organs, invigorate blood circulation, fill the effects such as flesh.
Thallus Laminariae (Thallus Eckloniae), salty in the mouth, cold in nature.Return liver, stomach, kidney channel.Eliminating phlegm and softening indurated mass eliminating stagnation, inducing diuresis to remove edema.
Sargassum is bitter in the mouth, salty, cold in nature, nontoxic.Lung; Spleen; Kidney; Liver stomach warp, softening the hard mass; Expectorant; Diuretic; Detumescent.
Pericarpium Citri Reticulatae Viride, bitter in the mouth, pungent, warm in nature.Return liver, gallbladder, stomach warp.There is soothing the liver dispelling the stagnated QI, effect that removing food stagnancyization is stagnant.
Pericarpium Citri Reticulatae, bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Rhizoma Sparganii is pungent, bitter, flat.Return liver, spleen channel, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.
Rhizoma Curcumae, pungent, bitter, temperature.Return liver, spleen channel, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.。
Wherein, Spica Prunellae in side, Radix Scrophulariae, Concha Ostreae have the merit of suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, heat clearing away eliminating stagnation, are monarch drug.Thallus Laminariae (Thallus Eckloniae), Sargassum, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Rhizoma Sparganii, Rhizoma Curcumae are the ministerial drug of this compositions, and Thallus Laminariae (Thallus Eckloniae), Sargassum mutual reinforcement between are use, to strengthen hard masses softening and resolving, and the power of inducing diuresis to remove edema; Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae mutual reinforcement between are use, to strengthen soothing the liver dispelling the stagnated QI, and effect that removing food stagnancyization is stagnant; Rhizoma Sparganii, Rhizoma Curcumae mutual reinforcement between are use, to strengthen removing blood stasis circulation of qi promoting, and the merit of removing food stagnancy pain relieving.With suppressing the hyperactive liver and subsiding YANG in side; The product of tranquillization with heavy prescription, heat clearing away eliminating stagnation are main, and be aided with hard masses softening and resolving, inducing diuresis to remove edema, soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant, removing blood stasis circulation of qi promoting, the medicine of removing food stagnancy pain relieving.All medicines share, and play nourishing YIN and clearing away heat altogether, dissipating phlegm and resolving masses, the merit of circulation of qi promoting removing blood stasis with potent drugs.
Beneficial effect of the present invention is: Chinese medicine composition of the present invention, according to " soothing the stagnant liver ", the principle of " disease caused by accumulations of pathogen should be treated with therapy of dispersion ", utilize pharmaceutical composition nourishing YIN and clearing away heat of the present invention, dissipating phlegm and resolving masses, circulation of qi promoting removing blood stasis with potent drugs carries out dialectical treating, take psychological counseling, adjustment rule of life again, strike a proper balance between work and rest, low fat diet etc. are conducive to setting up live and work order that is happy, rule, can reach effect for the treatment of both the principal and secondary aspects of a disease to cyclomastopathy.Detailed description of the invention
Embodiment is only for further illustrating the present invention below, does not limit the scope of the invention in any form.
Embodiment 1 present composition capsule prescription and preparation method: get Spica Prunellae 30g, Radix Scrophulariae 30g, Concha Ostreae 30g, Thallus Laminariae (Thallus Eckloniae) 15g, Sargassum 12g, Pericarpium Citri Reticulatae Viride 9g, Pericarpium Citri Reticulatae 9g, Rhizoma Sparganii 6g, Rhizoma Curcumae 6g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant intends selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (soluble starch, sodium carboxymethyl cellulose, polyvidone) stirs, obtained soft material.Cross 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.
Embodiment 2 present composition capsule prescription and preparation method: get Spica Prunellae 35g, Radix Scrophulariae 35g, Concha Ostreae 35g, Thallus Laminariae (Thallus Eckloniae) 18g, Sargassum 15g, Pericarpium Citri Reticulatae Viride 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Sparganii 8g, Rhizoma Curcumae 8g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant intends selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (soluble starch, sodium carboxymethyl cellulose, polyvidone) stirs, obtained soft material.Cross 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.
Embodiment 3 present composition capsule prescription and preparation method: get Spica Prunellae 40g, Radix Scrophulariae 40g, Concha Ostreae 40g, Thallus Laminariae (Thallus Eckloniae) 12g, Sargassum 15g, Pericarpium Citri Reticulatae Viride 8g, Pericarpium Citri Reticulatae 10g, Rhizoma Sparganii 5g, Rhizoma Curcumae 5g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant intends selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (soluble starch, sodium carboxymethyl cellulose, polyvidone) stirs, obtained soft material.Cross 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.
Embodiment 4 present composition capsule prescription and preparation method: get Spica Prunellae 25g, Radix Scrophulariae 25g, Concha Ostreae 25g, Thallus Laminariae (Thallus Eckloniae) 10g, Sargassum 15g, Pericarpium Citri Reticulatae Viride 9g, Pericarpium Citri Reticulatae 9g, Rhizoma Sparganii 6g, Rhizoma Curcumae 6g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant intends selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (soluble starch, sodium carboxymethyl cellulose, polyvidone) stirs, obtained soft material.Cross 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.
Embodiment 5 present composition water decoction prescription and preparation method: get Spica Prunellae 30g, Radix Scrophulariae 30g, Concha Ostreae 30g, Thallus Laminariae (Thallus Eckloniae) 15g, Sargassum 12g, Pericarpium Citri Reticulatae Viride 9g, Pericarpium Citri Reticulatae 9g, Rhizoma Sparganii 6g, Rhizoma Curcumae 6g, mixing, in crude drug, add the water of 5 times of quality, soak after 1.5 hours, decoct 30 minutes, filter; Medicinal residues add the water of 3 times of quality again, decoct 20 minutes, filter; Merge twice filtrate, make water decoction.
Embodiment 6 present composition granule prescription and preparation method: get Spica Prunellae 30g, Radix Scrophulariae 30g, Concha Ostreae 30g, Thallus Laminariae (Thallus Eckloniae) 15g, Sargassum 12g, Pericarpium Citri Reticulatae Viride 9g, Pericarpium Citri Reticulatae 9g, Rhizoma Sparganii 6g, Rhizoma Curcumae 6g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant intends selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (soluble starch, sodium carboxymethyl cellulose, polyvidone) stirs, obtained soft material.Cross 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate respectively after dry granule cooling, to obtain final product.
Embodiment 7 present composition electuary prescription and preparation method: get Spica Prunellae 30g, Radix Scrophulariae 30g, Concha Ostreae 30g, Thallus Laminariae (Thallus Eckloniae) 15g, Sargassum 12g, Pericarpium Citri Reticulatae Viride 9g, Pericarpium Citri Reticulatae 9g, Rhizoma Sparganii 6g, Rhizoma Curcumae 6g, mixing, dries, grinds.Water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate.Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste.Add the adjuvant of proper proportion in thick paste, adjuvant intends selecting sucrose or lactose (sugar type granules selects mannitol, aspartame, stevioside), dextrin (soluble starch, sodium carboxymethyl cellulose, polyvidone) stirs, obtained soft material.Crushed 10 mesh sieves, obtain wet granular.50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate respectively after dry granule cooling, make powder or graininess electuary.
Embodiment 8 neat certain, female, 29 years old, mastalgia, have lump, nipple often has discharge, menoxenia, irritability, clinical diagnosis is cyclomastopathy, doctor write a prescription for: get Spica Prunellae 30g, Radix Scrophulariae 30g, Concha Ostreae 30g, Thallus Laminariae (Thallus Eckloniae) 15g, Sargassum 12g, Pericarpium Citri Reticulatae Viride 9g, Pericarpium Citri Reticulatae 9g, Rhizoma Sparganii 6g, Rhizoma Curcumae 6g, take the capsule of embodiment 1 every day at twice, each 3-4 grain, a course for the treatment of 1 Monday, serve on for two courses for the treatment of.Mastalgia alleviates, and lump dissipates, after taking 14 days, and various transference cure.
More than describe preferred embodiment of the present invention in detail.Should be appreciated that those of ordinary skill in the art just design according to the present invention can make many modifications and variations without the need to creative work.Therefore, all technical staff in the art, all should by the determined protection domain of claims under this invention's idea on the basis of existing technology by the available technical scheme of logical analysis, reasoning, or a limited experiment.
Claims (9)
1. treat the pharmaceutical composition of cyclomastopathy for one kind, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Spica Prunellae 20-50 part, Radix Scrophulariae 20-50 part, Concha Ostreae 20-50 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Sargassum 10-18 part, Pericarpium Citri Reticulatae Viride 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Sparganii 1-10 part, Rhizoma Curcumae 1-10 part.
2. a kind of pharmaceutical composition for the treatment of cyclomastopathy according to claim 1, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Spica Prunellae 25-45 part, Radix Scrophulariae 25-45 part, Concha Ostreae 25-45 part, Thallus Laminariae (Thallus Eckloniae) 12-18 part, Sargassum 10-15 part, Pericarpium Citri Reticulatae Viride 6-12 part, Pericarpium Citri Reticulatae 6-12 part, Rhizoma Sparganii 3-9 part, Rhizoma Curcumae 3-9 part.
3. the pharmaceutical composition of a kind of cyclomastopathy according to claim 1, is characterized in that these pharmaceutical composition parts by weight are counted: Spica Prunellae 30 parts, Radix Scrophulariae 30 parts, Concha Ostreae 30 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Sargassum 12 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae 9 parts, Rhizoma Sparganii 6 parts, Rhizoma Curcumae 6 parts.
4. the preparation of the Chinese medicine composition according to any one of claim 1-3, is characterized in that, described preparation is capsule preparations.
5. preparation according to claim 4, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.
6. preparation according to claim 5, is characterized in that, described preparation is capsule.
7. preparation according to claim 6, is characterized in that, the preparation method of described water decoction is:
1) get recipe quantity Spica Prunellae, Radix Scrophulariae, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Rhizoma Sparganii, Rhizoma Curcumae, mixing, dry, grind;
2) water extraction twice, first time adds 10 times amount water extraction 1h, and filter, medicinal residues add 8 times amount water extraction 1h again, filters, merges twice filtrate; Be evaporated to relative density 1.20 ~ 1.30, obtain Aqueous extracts thick paste;
3) add the adjuvant of proper proportion in thick paste, stir, obtained soft material;
4) cross 10 mesh sieves, obtain wet granular;
5) 50 ~ 60 DEG C of dryings, cross 10 mesh sieves and 65 mesh sieve granulate after dry granule cooling respectively, encapsulated, to obtain final product.
8. preparation according to claim 7, is characterized in that, the adjuvant of preparing of described capsule is: one or more combinations in sucrose, lactose, mannitol, aspartame, stevioside, dextrin, soluble starch, sodium carboxymethyl cellulose, polyvidone.
9. the application of the Chinese medicine composition described in any one of claim 1-3 in preparation treatment cyclomastopathy medicine.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104984007A (en) * | 2015-07-12 | 2015-10-21 | 四川金堂海纳生物医药技术研究所 | Medicine capable of effectively treating mammary lobular hyperplasia and preparing method of medicine |
CN107019780A (en) * | 2017-02-04 | 2017-08-08 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine composition for treating the proliferation of mammary gland |
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JPH01172331A (en) * | 1987-12-26 | 1989-07-07 | Nisshin Flour Milling Co Ltd | Preventive and remedy for infectious diseases of pasteurella haemolytica of mammals |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104984007A (en) * | 2015-07-12 | 2015-10-21 | 四川金堂海纳生物医药技术研究所 | Medicine capable of effectively treating mammary lobular hyperplasia and preparing method of medicine |
CN107019780A (en) * | 2017-02-04 | 2017-08-08 | 洛阳士雄聚元医疗集团股份有限公司 | A kind of Chinese medicine composition for treating the proliferation of mammary gland |
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