CN104623120A - Weight reducing and liver protecting health product and preparation method thereof - Google Patents
Weight reducing and liver protecting health product and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a weight reducing and liver protecting health product and a preparation method thereof, and belongs to the field of uses of weight reducing and liver protecting health foods. The product is composed of 200-500 parts of L-Carnitine-L-Tartrate, 10-200 parts of green tea extract, 10-200 parts of grape seed extract, 10-200 parts of Rheum officinale extract, 10-200 parts of lotus leaf extract, 10-200 parts of gingkgo extract, 10-200 parts of Herba Taraxaci extract, 10-200 parts of licorice root extract, 10-200 parts of Centella asiatica extract, 10-200 parts of Gynostemma pentaphylla extract, 100-400 parts of N-acetyl-L-cysteine, 1-1000 parts of an excipient, 1-100 parts of an adhesive, 1-100 parts of a disintegrating agent, 1-100 parts of a lubricant and 1-100 parts of a dressing premix. The product containing various extracts with metabolism enhancing, liver protection and other efficacies, so the product has good treatment and prevention effects on obesity and liver injury, has high absorption and utilization rate, and is especially suitable for obesity and liver injury people.
Description
Technical field
The invention belongs to fat-reducing and liver-protecting health food purposes field, be specifically related to a kind of fat-reducing and liver-protection health-care product and preparation method thereof.
Background technology
Now, obesity has become the popular chronic disease of modern society, the obese people of European and American developed countries accounts for adult population's 1/3rd, in nearly 10 years, the overweight people of some countries turn increases more than 1 times, serious reaches 40%, the reason causeed fat is existing endogenous, as gene, age increases, menopausal women, sexual hormone disturbance etc., also exogen is had, as too much in taken in heat, hypomotility, do not have enough sleep, the product of losing weight in the market roughly has containing appetite suppressant, diuretic, stimulate class medicine, the product of the compositions such as cathartic, be based upon fast dewatering with on slimming basis, not the minimizing fat of real meaning, therefore not only useless, nutrition also can be caused to interrupt, bring collapse, hypoglycemia and bring out various serious side effect, therefore be worthless, obesity be one by heredity, environment, the reciprocal actions such as life style and the morbid state formed, a kind of caused by body fat excess accumulation, therefore obesity should from changing lifestyles, add sharp movement and wait hands, to reach for the purpose of the accumulation reducing fat, as suitably reduced high-energy, high fat diet, make fat be transformed into energy expenditure by motion to fall, to make steatolysis unnecessary in body, or utilize the material that can bring out lipase active, to promote the activity of body fat catabolic enzyme or acyl coenzyme A, enable acceleration in vivo consumes superabundant fats, or suppress the activity of fatty acid synthetase, to hinder fat synthesis in vivo.
Liver is important substance metabolism organ, at carbohydrate, lipid, protein, vitamin, hormone, the absorption of the materials such as bile, storage, biological conversion, secretion, the aspects such as excretion all play an important role, it is the important armour of human body, the function that there is removing toxic substances and engulf, that important blood regulates organ, participate in the synthesis of many thrombins in blood, participate in hematopoiesis, storage and release Hemopoietic factor, it is the synthetic organ of many enzymes in human body, ensure the normal metabolic processes of human body, there is powerful regeneration and compensatory capacity, slight or limitation damage can be overcome and unlikelyly cause hepatic insufficiency.But many cause of disease can cause distortion and the necrosis of hepatic parenchymal cells, cause liver cirrhosis.Current hepatic injury is broadly divided into: hepatitis, poisoning and chemical injury caused by medicine, owing to taking in higher fatty acid, high caloric diet or fatty liver, hepatocarcinoma etc. too much caused by ethanol for a long time.
Existing slimming health product, although can play certain effect of weight reducing, weight losing function is single, absorption rate is low.In addition, general slimming health product all has certain influence to human liver, not only can solve fat so need to provide a kind of but also can not injure the health product of liver.
Summary of the invention
Single for existing slimming health product weight losing function, absorption rate is low; and human liver is all had to the problem of certain influence; the invention provides a kind of fat-reducing and liver-protection health-care product and preparation method thereof; it contains the multiple extract with effect such as enhancing metabolism and the liver protecting etc.; therefore good treatment and preventive effect is had to obesity and hepatic injury; and there is the high feature of absorption rate, be specially adapted to the crowd of obesity and hepatic injury.
L-carnitine-L-tartrate physiological function: antiobesity action, resisting fatigue, promotion infants growth and development, slow down aging, adjusting blood lipid, raising old people cognition and identification ability.
Green tea extract physiological function: slow down aging, auxiliary Tumor suppression, antioxidation, resisting fatigue, caries prevention, suppression blood middle cholesterol content, suppress blood glucose to raise, lose weight, protect gastric mucosa, alleviate halitosis, Adsorption of Heavy Metals.
Semen Vitis viniferae extract physiological function: antioxidation, slow down aging, blood fat reducing, reduce blood pressure, protect cardiovascular and cerebrovascular vessel, Tumor suppression, radioprotective, beauty treatment, improve vision.
Radix Et Rhizoma Rhei extract physiological function: relieving constipation is dropped, hepatoprotective, suppression diabetic renal hypertrophy, reduce blood glucose and kidney oxygen consumption, hemostasis, anti-inflammation, maincenter are antipyretic.
Folium Nelumbinis extract physiological function: blood fat reducing, antioxidation, fat-reducing, blood pressure lowering.
Semen Ginkgo extrac physiological function: improve blood circulation, blood fat reducing, protection cerebral tissue, eliminate free radical, defying age, beauty treatment, caries prevention, blood pressure lowering, diuresis, improve bronchial asthma.
Dandelion extract physiological function: antibacterial, the liver protecting, protection gastric mucosa, Tumor suppression.
Radix Glycyrrhizae extract physiological function: the liver protecting, Antiulcer activity, spasmolytic, antiviral, relieving cough and expelling phlegm, antioxidation, press down cancer.
Herba Centellae extract physiological function: protection gastric mucosa, antibacterial, Improving memory.
Herb Gynostemmae Pentaphylli extract physiological function: adjusting blood lipid and to the protective effect of heart, immunomodulating, adjustment blood pressure and anoxia tolerance function, auxiliary Tumor suppression, slow down aging, resisting fatigue.
N-acetyl-L-cysteine physiological function: pre-radioprotective, the liver protecting.
The present invention adopts following technical scheme:
A kind of fat-reducing and liver-protection health-care product, be made up of the raw material of following weight portion: L-carnitine-L-tartrate 200 ~ 500 parts, green tea extract 10 ~ 200 parts, Semen Vitis viniferae extract 10 ~ 200 parts, Radix Et Rhizoma Rhei extract 10 ~ 200 parts, Folium Nelumbinis extract 10 ~ 200 parts, Semen Ginkgo extrac 10 ~ 200 parts, dandelion extract 10 ~ 200 parts, Radix Glycyrrhizae extract 10 ~ 200 parts, Herba Centellae extract 10 ~ 200 parts, Herb Gynostemmae Pentaphylli extract 10 ~ 200 parts, N-acetyl-L-cysteine 100 ~ 400 parts, excipient 1 ~ 1000 part, binding agent 1 ~ 100 part, disintegrating agent 1 ~ 100 part, lubricant 1 ~ 100 part, coating pre-mixing agent 1 ~ 100 part.
Preferred excipient is one or more the compositions in starch, microcrystalline Cellulose, calcium hydrogen phosphate, dextrin, is more preferably microcrystalline Cellulose and calcium hydrogen phosphate.
Preferred disintegrating agent is one or more the combination in crospolyvinylpyrrolidone, carboxymethyl starch sodium, cross-linking sodium carboxymethyl cellulose, is preferably cross-linking sodium carboxymethyl cellulose.
Preferred emollient is one or both the compositions in magnesium stearate, micropowder silica gel, is more preferably magnesium stearate.
Preferred adhesive is one in polyvinylpyrrolidone, sodium carboxymethyl cellulose, starch, hydroxypropyl emthylcellulose or compositions of more than two kinds, is more preferably starch.
Preferred coating pre-mixing agent component is the mixture in titanium dioxide, polyoxyethylene, Pulvis Talci, PEG, HPMC, lecithin.
The present composition preparation method carry out according to the following steps:
Step 1: get L-carnitine-L-tartrate 200 ~ 500 parts, green tea extract 10 ~ 200 parts, Semen Vitis viniferae extract 10 ~ 200 parts, Radix Et Rhizoma Rhei extract 10 ~ 200 parts, Folium Nelumbinis extract 10 ~ 200 parts, Semen Ginkgo extrac 10 ~ 200 parts, dandelion extract 10 ~ 200 parts, Radix Glycyrrhizae extract 10 ~ 200 parts, Herba Centellae extract 10 ~ 200 parts, Herb Gynostemmae Pentaphylli extract 10 ~ 200 parts, N-acetyl-L-cysteine 100 ~ 400 parts, excipient 1 ~ 1000 part, binding agent 1 ~ 100 part, disintegrating agent 1 ~ 100 part, lubricant 1 ~ 100 part, coating pre-mixing agent 1 ~ 100 part is for subsequent use,
Step 2: the aqueous solution configuring 1 ~ 25% of binding agent, be fully dissolved to clear, preferred adhesive is starch;
Step 3: the L-carnitine-L-tartrate in step 1, N-acetyl-L-cysteine, calcium hydrogen phosphate were pulverized 60 ~ 120 mesh sieves respectively;
Step 4: stir in the green tea extract in the L-carnitine-L-tartrate in step 3, N-acetyl-L-cysteine, calcium hydrogen phosphate and step 1, Semen Vitis viniferae extract, Radix Et Rhizoma Rhei extract, Folium Nelumbinis extract, Semen Ginkgo extrac, dandelion extract, Radix Glycyrrhizae extract, Herba Centellae extract, Herb Gynostemmae Pentaphylli extract, microcrystalline Cellulose, input wet granulator 1 ~ 10 minute;
Step 5: the solution of step 2 binding agent is added wet granulator, wet granulation, dry, cross 12 ~ 20 mesh sieves;
Step 6: add the excipient in step 1 in step 5 gained granule, disintegrating agent, lubricant fully mix, preferred excipient is microcrystalline Cellulose and calcium hydrogen phosphate, preferred disintegrating agent is cross-linking sodium carboxymethyl cellulose, preferred emollient is magnesium stearate, by tabletting after high performance liquid chromatography detection L-carnitine-L-tartrate content;
Step 7: preparation coating pre-mixing agent solution, compound concentration is 1 ~ 18%, control inlet temperature 80 ~ 110 DEG C, sheet bed tempertaure 40 ~ 60 DEG C, the leaving air temp 50 ~ 70 DEG C during coating, carry out coating to the tablet that step 6 obtains according to turnadle pan coating, wherein coating pre-mixing agent component is the mixture in titanium dioxide, polyoxyethylene, Pulvis Talci, PEG, HPMC, lecithin.
In addition, be also added with appropriate wetting agent in the present invention, wetting agent is preferably water or dehydrated alcohol.
According to the film-making requirement of tablet, prescription screening test adjustment major ingredient and the consumption of various adjuvant, reach optimal proportion, makes to draw moistly greatly to reduce, and mobility increases, and the stability of product strengthens.
The main composition finally determined is: every sheet contains L-carnitine-L-tartrate 200-500mg, green tea extract 10-200mg, Semen Vitis viniferae extract 10-200mg, Radix Et Rhizoma Rhei extract 10-200mg, Folium Nelumbinis extract 10-200mg, Semen Ginkgo extrac 10-200mg, dandelion extract 10-200mg, Radix Glycyrrhizae extract 10-200mg, Herba Centellae extract 10-200mg, Herb Gynostemmae Pentaphylli extract 10-200mg, N-acetyl-L-cysteine 100-400mg, microcrystalline Cellulose 1-500mg, calcium hydrogen phosphate 1-500mg, cross-linked carboxymethyl fiber sodium 1-100mg, starch 1-100mg, magnesium stearate 1-100mg, coating pre-mixing agent 1-100mg.
Comparatively preferred prescription mainly forms: every sheet contains L-carnitine-L-tartrate 300-400mg, green tea extract 30-100mg, Semen Vitis viniferae extract 30-100mg, Radix Et Rhizoma Rhei extract 30-100mg, Folium Nelumbinis extract 30-100mg, Semen Ginkgo extrac 30-100mg, dandelion extract 30-100mg, Radix Glycyrrhizae extract 30-100mg, Herba Centellae extract 30-100mg, Herb Gynostemmae Pentaphylli extract 30-100mg, N-acetyl-L-cysteine 200-300mg, microcrystalline Cellulose 2-400mg, calcium hydrogen phosphate 2-400mg, cross-linked carboxymethyl fiber sodium 2-70mg, starch 2-70mg, magnesium stearate 2-30mg, coating pre-mixing agent 10-70mg.
, beneficial effect
Compared to prior art, beneficial effect of the present invention is:
(1) main component of the present composition is made up of L-carnitine-L-tartrate, green tea extract, Semen Vitis viniferae extract, Radix Et Rhizoma Rhei extract, Folium Nelumbinis extract, Semen Ginkgo extrac, dandelion extract, Radix Glycyrrhizae extract, Herba Centellae extract, Herb Gynostemmae Pentaphylli extract, N-acetyl-L-cysteine; with the addition of the active component of one or more energy hepatoprotective; containing multiple, there is the extract strengthening the effect such as metabolism and the liver protecting, therefore have good treatment and preventive effect to obesity and hepatic injury.
(2) also contain the auxiliary material such as excipient, disintegrating agent, lubricant in the present composition, obtained disintegration of tablet performance is better, and stripping is fast, and onset is rapid, has the advantages that absorption rate is high, is specially adapted to the crowd of obesity and hepatic injury.
Detailed description of the invention
For understanding content of the present invention further, describing the present invention below in conjunction with specific embodiment, but being not limited only to following instance.
embodiment 1
Get every sheet and contain L-carnitine-L-tartrate 350mg, green tea extract 70mg, Semen Vitis viniferae extract 60mg, Radix Et Rhizoma Rhei extract 65mg, Folium Nelumbinis extract 80mg, Semen Ginkgo extrac 75mg, dandelion extract 70mg, Radix Glycyrrhizae extract 85mg, Herba Centellae extract 60mg, Herb Gynostemmae Pentaphylli extract 70mg, N-acetyl-L-cysteine 250mg, microcrystalline Cellulose 300mg, calcium hydrogen phosphate 300mg, cross-linked carboxymethyl fiber sodium 60mg, starch 60mg, magnesium stearate 20mg, coating pre-mixing agent component titanium dioxide 11mg, polyoxyethylene 2.5mg, Pulvis Talci 2mg, PEG6000 5mg, HPMC 13mg, lecithin 1.5mg is for subsequent use.
Prepare according to following step:
Step 1: configuration starch slurry, slurrying concentration 10%.
Step 2: L-carnitine-L-tartrate, N-acetyl-L-cysteine, calcium hydrogen phosphate were pulverized 60 ~ 120 mesh sieves respectively.
Step 3: L-carnitine-L-tartrate, green tea extract, Semen Vitis viniferae extract, Radix Et Rhizoma Rhei extract, Folium Nelumbinis extract, Semen Ginkgo extrac, dandelion extract, Radix Glycyrrhizae extract, Herba Centellae extract, Herb Gynostemmae Pentaphylli extract, N-acetyl-L-cysteine, microcrystalline Cellulose, calcium hydrogen phosphate are dropped in wet granulator and stir 1 ~ 10 minute.
Step 4: the starch solution in step 1 is added wet granulator, wet granulation, dry, cross 12 ~ 20 mesh sieves.
Step 5: add microcrystalline Cellulose and calcium hydrogen phosphate, cross-linking sodium carboxymethyl cellulose, magnesium stearate in step 4 gained granule, fully mix, by tabletting after high performance liquid chromatography detection L-carnitine-L-tartrate content.
Step 6: preparation coating pre-mixing agent solution, compound concentration is 1 ~ 18%, controls inlet temperature 80 ~ 110 DEG C, sheet bed tempertaure 40 ~ 60 DEG C, leaving air temp 50 ~ 70 DEG C during coating, carries out coating to the tablet that step 5 obtains according to turnadle pan coating.
embodiment 2
Get every sheet and contain L-carnitine-L-tartrate 300mg, green tea extract 30mg, Semen Vitis viniferae extract 30mg, Radix Et Rhizoma Rhei extract 30mg, Folium Nelumbinis extract 30mg, Semen Ginkgo extrac 30mg, dandelion extract 30mg, Radix Glycyrrhizae extract 30mg, Herba Centellae extract 30mg, Herb Gynostemmae Pentaphylli extract 30mg, N-acetyl-L-cysteine 200mg, microcrystalline Cellulose 2mg, calcium hydrogen phosphate 2mg, cross-linked carboxymethyl fiber sodium 2mg, starch 2mg, magnesium stearate 2mg, coating pre-mixing agent component titanium dioxide 2.5mg, polyoxyethylene 1 .5mg, Pulvis Talci 1.5mg, PEG6000 1mg, HPMC 2mg, lecithin 1.5mg is for subsequent use.
Prepare according to following step:
Step 1: configuration starch slurry, slurrying concentration 10%.
Step 2: L-carnitine-L-tartrate, N-acetyl-L-cysteine, calcium hydrogen phosphate were pulverized 60 ~ 120 mesh sieves respectively.
Step 3: L-carnitine-L-tartrate, green tea extract, Semen Vitis viniferae extract, Radix Et Rhizoma Rhei extract, Folium Nelumbinis extract, Semen Ginkgo extrac, dandelion extract, Radix Glycyrrhizae extract, Herba Centellae extract, Herb Gynostemmae Pentaphylli extract, N-acetyl-L-cysteine, microcrystalline Cellulose, calcium hydrogen phosphate are dropped in wet granulator and stir 1 ~ 10 minute.
Step 4: the starch solution in step 1 is added wet granulator, wet granulation, dry, cross 12 ~ 20 mesh sieves.
Step 5: add microcrystalline Cellulose and calcium hydrogen phosphate, cross-linking sodium carboxymethyl cellulose, magnesium stearate in step 4 gained granule, fully mix, by tabletting after high performance liquid chromatography detection L-carnitine-L-tartrate content.
Step 6: preparation coating pre-mixing agent solution, compound concentration is 1 ~ 18%, controls inlet temperature 80 ~ 110 DEG C, sheet bed tempertaure 40 ~ 60 DEG C, leaving air temp 50 ~ 70 DEG C during coating, carries out coating to the tablet that step 5 obtains according to turnadle pan coating.
embodiment 3
Get L-carnitine-L-tartrate 400mg, green tea extract 100mg, Semen Vitis viniferae extract 100mg, Radix Et Rhizoma Rhei extract 100mg, Folium Nelumbinis extract 100mg, Semen Ginkgo extrac 100mg, dandelion extract 100mg, Radix Glycyrrhizae extract 100mg, Herba Centellae extract 100mg, Herb Gynostemmae Pentaphylli extract 100mg, N-acetyl-L-cysteine 300mg, microcrystalline Cellulose 400mg, calcium hydrogen phosphate 400mg, cross-linked carboxymethyl fiber sodium 70mg, starch 70mg, magnesium stearate 30mg, coating pre-mixing agent component titanium dioxide 21mg, polyoxyethylene 5.5mg, Pulvis Talci 3.5mg, PEG6000 10mg, HPMC28mg, lecithin 2mg.
Prepare according to following step:
Step 1: configuration starch slurry, slurrying concentration 10%.
Step 2: L-carnitine-L-tartrate, N-acetyl-L-cysteine, calcium hydrogen phosphate were pulverized 60 ~ 120 mesh sieves respectively.
Step 3: L-carnitine-L-tartrate, green tea extract, Semen Vitis viniferae extract, Radix Et Rhizoma Rhei extract, Folium Nelumbinis extract, Semen Ginkgo extrac, dandelion extract, Radix Glycyrrhizae extract, Herba Centellae extract, Herb Gynostemmae Pentaphylli extract, N-acetyl-L-cysteine, microcrystalline Cellulose, calcium hydrogen phosphate are dropped in wet granulator and stir 1 ~ 10 minute.
Step 4: the starch solution in step 1 is added wet granulator, wet granulation, dry, cross 12 ~ 20 mesh sieves.
Step 5: add microcrystalline Cellulose and calcium hydrogen phosphate, cross-linking sodium carboxymethyl cellulose, magnesium stearate in step 4 gained granule, fully mix, by tabletting after high performance liquid chromatography detection L-carnitine-L-tartrate content.
Step 6: preparation coating pre-mixing agent solution, compound concentration is 1 ~ 18%, controls inlet temperature 80 ~ 110 DEG C, sheet bed tempertaure 40 ~ 60 DEG C, leaving air temp 50 ~ 70 DEG C during coating, carries out coating to the tablet that step 5 obtains according to turnadle pan coating.
Below be only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (7)
1. a fat-reducing and liver-protection health-care product, it is characterized in that, be made up of the raw material of following weight portion: L-carnitine-L-tartrate 200 ~ 500 parts, green tea extract 10 ~ 200 parts, Semen Vitis viniferae extract 10 ~ 200 parts, Radix Et Rhizoma Rhei extract 10 ~ 200 parts, Folium Nelumbinis extract 10 ~ 200 parts, Semen Ginkgo extrac 10 ~ 200 parts, dandelion extract 10 ~ 200 parts, Radix Glycyrrhizae extract 10 ~ 200 parts, Herba Centellae extract 10 ~ 200 parts, Herb Gynostemmae Pentaphylli extract 10 ~ 200 parts, N-acetyl-L-cysteine 100 ~ 400 parts, excipient 1 ~ 1000 part, binding agent 1 ~ 100 part, disintegrating agent 1 ~ 100 part, lubricant 1 ~ 100 part, coating pre-mixing agent 1 ~ 100 part.
2. one fat-reducing according to claim 1 and liver-protection health-care product, it is characterized in that, described excipient is one or more the compositions in starch, microcrystalline Cellulose, calcium hydrogen phosphate, dextrin, is preferably microcrystalline Cellulose and calcium hydrogen phosphate.
3. one fat-reducing according to claim 1 and liver-protection health-care product, it is characterized in that, disintegrating agent is one or more the combination in crospolyvinylpyrrolidone, carboxymethyl starch sodium, cross-linking sodium carboxymethyl cellulose, is preferably cross-linking sodium carboxymethyl cellulose.
4. one fat-reducing according to claim 1 and liver-protection health-care product, it is characterized in that, lubricant is one or both the compositions in magnesium stearate, micropowder silica gel, is preferably magnesium stearate.
5. one fat-reducing according to claim 1 and liver-protection health-care product, is characterized in that, binding agent is one in polyvinylpyrrolidone, sodium carboxymethyl cellulose, starch, hydroxypropyl emthylcellulose or compositions of more than two kinds, preferably starch.
6., according to the one fat-reducing in claim 1-5 described in any one and liver-protection health-care product, it is characterized in that, described coating pre-mixing agent component is the mixture in titanium dioxide, polyoxyethylene, Pulvis Talci, PEG, HPMC, lecithin.
7. a health product preparation method for fat-reducing and hepatoprotective, is characterized in that carrying out according to the following steps:
Step 1: get L-carnitine-L-tartrate 200 ~ 500 parts, green tea extract 10 ~ 200 parts, Semen Vitis viniferae extract 10 ~ 200 parts, Radix Et Rhizoma Rhei extract 10 ~ 200 parts, Folium Nelumbinis extract 10 ~ 200 parts, Semen Ginkgo extrac 10 ~ 200 parts, dandelion extract 10 ~ 200 parts, Radix Glycyrrhizae extract 10 ~ 200 parts, Herba Centellae extract 10 ~ 200 parts, Herb Gynostemmae Pentaphylli extract 10 ~ 200 parts, N-acetyl-L-cysteine 100 ~ 400 parts, excipient 1 ~ 1000 part, binding agent 1 ~ 100 part, disintegrating agent 1 ~ 100 part, lubricant 1 ~ 100 part, coating pre-mixing agent 1 ~ 100 part is for subsequent use,
Step 2: the aqueous solution configuring 1 ~ 25% of binding agent, be fully dissolved to clear, preferred adhesive is starch;
Step 3: the L-carnitine-L-tartrate in step 1, N-acetyl-L-cysteine, calcium hydrogen phosphate were pulverized 60 ~ 120 mesh sieves respectively;
Step 4: stir in the green tea extract in the L-carnitine-L-tartrate in step 3, N-acetyl-L-cysteine, calcium hydrogen phosphate and step 1, Semen Vitis viniferae extract, Radix Et Rhizoma Rhei extract, Folium Nelumbinis extract, Semen Ginkgo extrac, dandelion extract, Radix Glycyrrhizae extract, Herba Centellae extract, Herb Gynostemmae Pentaphylli extract, microcrystalline Cellulose, input wet granulator 1 ~ 10 minute;
Step 5: the solution of step 2 binding agent is added wet granulator, wet granulation, dry, cross 12 ~ 20 mesh sieves;
Step 6: add the excipient in step 1 in step 5 gained granule, disintegrating agent, lubricant fully mix, preferred excipient is microcrystalline Cellulose and calcium hydrogen phosphate, preferred disintegrating agent is cross-linking sodium carboxymethyl cellulose, preferred emollient is magnesium stearate, by tabletting after high performance liquid chromatography detection L-carnitine-L-tartrate content;
Step 7: preparation coating pre-mixing agent solution, compound concentration is 1 ~ 18%, control inlet temperature 80 ~ 110 DEG C, sheet bed tempertaure 40 ~ 60 DEG C, the leaving air temp 50 ~ 70 DEG C during coating, carry out coating to the tablet that step 6 obtains according to turnadle pan coating, wherein coating pre-mixing agent component is the mixture in titanium dioxide, polyoxyethylene, Pulvis Talci, PEG, HPMC, lecithin.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107551065A (en) * | 2016-07-01 | 2018-01-09 | 捷通国际有限公司 | The composition and application method based on plant for body weight control |
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| CN101653451A (en) * | 2009-09-04 | 2010-02-24 | 江苏江山制药有限公司 | Health product for keeping joint health and increasing bone density and preparation method thereof |
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| CN101653451A (en) * | 2009-09-04 | 2010-02-24 | 江苏江山制药有限公司 | Health product for keeping joint health and increasing bone density and preparation method thereof |
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| CN107551065A (en) * | 2016-07-01 | 2018-01-09 | 捷通国际有限公司 | The composition and application method based on plant for body weight control |
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