CN104606413A - Composition for treating pain caused by femoral head necrosis and preparation method for composition - Google Patents
Composition for treating pain caused by femoral head necrosis and preparation method for composition Download PDFInfo
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Abstract
The invention discloses composition for treating pain caused by femoral head necrosis. The composition is prepared from the following raw materials in parts by weight: 1-5 parts of tortoise shells, 2-4 parts of calcium gluconate tablets, 3-7 parts of safflower, 2-6 parts of garden balsam stem, 4-8 parts of cortex acanthopanacis, 10-15 parts of oldenlandia diffusa, 5-15 parts of myrrh, 5-10 parts of obscured homalomena rhizome, 2-4 parts of colchicine tablets, 4-8 parts of pseudo-ginseng, 10-20 parts of ligusticum wallichii, 5-15 parts of rhizoma corydalis, 6-16 parts of radix angelicae pubescentis, 3-9 parts of rhizoma drynariae and 10-14 parts of vitamin B. The composition has a remarkable effect on the pain caused by the femoral head necrosis, reasonably combines traditional Chinese medicines with effects of promoting blood circulation to remove blood stasis, relaxing tendons, activating collaterals, tonifying vital energy, relieving pain, replenishing blood and strengthening bones with Western medicines with effects of relieving pain, diminishing inflammation and strengthening bones, improves immunity of a human body, does not have toxic or side effects, and improves fragile health of a patient due to long-term illness; moreover, local common medicinal materials are mainly selected and used, so that the price is low and the financial burden of the patient is reduced.
Description
Technical field
The invention belongs to traditional Chinese medicine field, particularly relate to the composition and method of making the same of the pain that a kind for the treatment of is caused by femur head necrosis.
Background technology
The pain caused by femur head necrosis is a Pathologic process, initially occurs in capital heavy burden district, and under stress, necrotic bone trabecular bone structure damage and micro-fracture occurs and subsequently for the repair process of injured bone.Cause the reason of osteonecrosis not eliminate, repair imperfection, the process of damage-reparation continues, and causes femoral head structural change, collapse of the femoral head, distortion, arthritis, dysfunction.The pain caused by femur head necrosis no doubt can cause slight illness, joint motion and walking with load dysfunction, but people are not by the impact of " bad and dead " word implication terror, and the pain pathological changes caused by femur head necrosis, limits to after all, involve indivedual joint, can alleviate, disappear and spontaneous recovery, even if seriously, finally can also be remedied by artificial hip joint replacing, still can recover walking ability.
The cause of disease: the bone aching caused by femur head necrosis has two kinds because of not outer: a kind of healing occurring in fracture of femoral neck malreduction, weight-bearing trabeculae in femoral head turns to the stress reduction of heavy burden area carrier, there is stress damage, so necrosis always occurs in patients with fractures's healing, after walking with load.Another kind is osseous tissue self pathological changes, as the osteonecrosis that modal chronic alcoholism or use glucocorticoid cause, and the Regeneration and Repair impairment of osseous tissue simultaneously.Comprise childhood development growth stage femoral head germinal center-femoral head epiphyseal necrosis in addition, also known as the pain that child is caused by femur head necrosis, coxa plana.
Clinical manifestation: the sings and symptoms of the pain caused by femur head necrosis is varied, the ailing time occurred, the degree of outbreak is also not quite similar, but is all based on Pathologic.And various clinical manifestation is not specific to the pain that caused by femur head necrosis, many Hip diseases can occur, and in other words, the diagnosis being difficult to be made by the subjective symptom of patient and clinical examination the pain caused by femur head necrosis is come.It is positive that the many pathological changes of such as hip and sacroiliac joint can show as the test of " 4 " word, (namely go down on one's knees and make the outward turning of hip joint flexing abduction, be put into " 4 " word shape to be placed on offside and to stretch on lower limb, on the other hand on pressing offside crista iliaca, another hands is placed on hands inside knee joint and presses down simultaneously, causes buttocks hip pain) therefore neither diagnose the specific sign of the pain caused by femur head necrosis.Modal symptom is exactly pain, and the position of pain is hip joint, thigh nearside, can be radiated to knee.Pain can cause because of the high pressure in the inflammatory disorders of slough-reparation or inflammation foci, can show as lasting pain, rest pain.Bone cartilage collapse-deformation causes traumatic arthritis, or has hip joint Surrounding muscles ligament attachment area chronic traumatic pain.Hip limitation of activity, particularly rotary moveable is limited, or has pain property and cripetura to walk lamely.
Authorization Notice No. CN 102743440 B(application number 201210265631.7) Chinese patent literature provide a kind of Chinese medicine for the treatment of femur head necrosis, it is characterized in that: the method mainly taking to be similar to scrape therapy is external scrapes the Chinese medicine that skin carries out meridians infiltration, be aided with mushroom Chinese medicine for oral administration and the medicine moxibustion Chinese medicine of kidney and bone health, be used for repairing the impaired vital organs of the human body, the kidney that reparation can cause femur head necrosis to sustain damage, reaches object and the good result for the treatment of femur head necrosis; Wherein, carry out the Chinese medicine of meridians infiltration by 14 taste raw material of Chinese medicine for the external skin that scrapes, carry out proportioning by following weight portion: Cordyceps militaris (L.) Link.: 40-60; Poria: 40-60; Rhizoma Cibotii: 10-30; Ramulus Mori: 10-30; Radix Angelicae Pubescentis: 10-30; Pheretima: 10-30; Eupolyphaga Seu Steleophaga: 10-30; Herba Epimedii: 10-30; Herba Pyrolae: 10-30; Radix Gentianae Macrophyllae: 5-20; Scolopendra: 5-20; Herba Lycopodii: 5-20; Fomes Pinicola: 5-20; Radix Glycyrrhizae Preparata: 5-15; Wherein, the mushroom Chinese medicine for oral administration being aided with kidney and bone health is made up of 10 taste mushroom Chinese medicines, carries out proportioning: Cordyceps militaris (L.) Link.: 40-60 by following weight portion; Poria: 10-30; Polyporus: 10-30; Auricularia: 10-30; Lentinus Edodes: 10-30; Tricholoma matsutake (lto et lmai) Singer: 5-20; Concretio silicea Bambusae seu schizostachyi: 5-20; Fomes Pinicola: 5-20; Marasmius androsaceus (L.ex Fr.) Fr.: 5-20; Hericium erinaceus (Bull. Ex Fr.) Pers.: 5-15.Authorization Notice No. CN 103006943 B(application number 201210508065.8) Chinese patent literature provide a kind of Chinese medicine for the treatment of femur head necrosis, it is characterized in that: the weight proportion of its each raw material components is: Herba Lycopodii 10-14, Rhizoma Homalomenae 8-12, Cortex Acanthopancis 6-10, Radix Salviae Miltiorrhizae 4-8, Flos Carthami 8-12, Semen Persicae 13-17, Radix Codonopsis 8-12, Radix Astragali 10-14, Caulis Spatholobi 13-17, Radix Angelicae Sinensis 6-10, Fructus Mori 8-12, Fructus Aurantii Immaturus 10-14, the Radix Aucklandiae 6, Meconopsis henrici Bur. et Franch. 13-17, Herba Verbenae 1-5, Rhizoma Panacis bipinnatifidi 10-14.
Also there are some problems treating in the pain that caused by femur head necrosis in foregoing invention: clinically to treating the pain caused by femur head necrosis, the curative effect of strengthening the tendons and bones is also undesirable.
Summary of the invention
For the present situation of the pain deficiency that existing treatment is caused by femur head necrosis, and provide the composition and method of making the same for the treatment of the pain caused by femur head necrosis, there is easy to operate, the evident in efficacy and feature had no side effect, inside of human body immunologic function can also be improved, the resistance against diseases of enhancing body, can improve capital blood circulation, increases blood flow, alleviate femur head necrosis degree, relaxing muscles and tendons to promote blood circulation, most importantly play the effect for the treatment of the pain caused by femur head necrosis.
Another object of the present invention is just to provide the preparation method of above-mentioned composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat the compositions of the pain caused by femur head necrosis, each crude drug is as follows, is weight portion: Carapax et Plastrum Testudinis 1-5, calcium gluconate tablet 2-4, Flos Carthami 3-7, Herba speranskiae tuberculatae 2-6, Cortex Acanthopancis 4-8, Herba Hedyotidis Diffusae 10-15, Myrrha 5-15, Rhizoma Homalomenae 5-10, colchicines tablets 2-4, Radix Notoginseng 4-8, Rhizoma Chuanxiong 10-20, Rhizoma Corydalis 5-15, Radix Angelicae Pubescentis 6-16, Rhizoma Drynariae 3-9, vitaminB10-14.
Treat the compositions of the pain caused by femur head necrosis, preferred scheme is, each crude drug is as follows, be weight portion: Carapax et Plastrum Testudinis 2-4, calcium gluconate tablet 2.5-3.5, Flos Carthami 4-6, Herba speranskiae tuberculatae 4-6, Cortex Acanthopancis 5-7, Herba Hedyotidis Diffusae 11-14, Myrrha 8-13, Rhizoma Homalomenae 6-9, colchicines tablets 2.5-3.5, Radix Notoginseng 5-7, Rhizoma Chuanxiong 13-18, Rhizoma Corydalis 8-13, Radix Angelicae Pubescentis 10-12, Rhizoma Drynariae 5-7, VB11-13.
Treat the compositions of the pain caused by femur head necrosis, better preferred scheme is that each crude drug is as follows, be weight portion: Carapax et Plastrum Testudinis 3, calcium gluconate tablet 3, Flos Carthami 5, Herba speranskiae tuberculatae 5, Cortex Acanthopancis 6, Herba Hedyotidis Diffusae 13, Myrrha 10, Rhizoma Homalomenae 7.5, colchicines tablets 3, Radix Notoginseng 6, Rhizoma Chuanxiong 15, Rhizoma Corydalis 10, Radix Angelicae Pubescentis 11, Rhizoma Drynariae 6, vitamin B12.
The preparation method of above-mentioned composition, step is as follows:
(1) dry clean for Carapax et Plastrum Testudinis, pinion with iron wire, big fire bake is crisp, grinds to form smalls, crosses 80-120 mesh sieve stand-by;
(2) Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar is soaked 5-15 hour, steam 20-40 minute, dryouied by large iron pan, rapidly drop into steamed crude drug, parch is flavoursome when sending, and cools, and to cross 80-120 mesh sieve for subsequent use for pulverization altogether;
(3) Herba Hedyotidis Diffusae, Myrrha, Rhizoma Homalomenae, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis and Rhizoma Drynariae are cleaned, dry, be cut into small pieces, be placed in by wheat bran in marmite, the sliding sharp state of parch, drops into the crude drug cut, stir-fry 4-8 minute fast, and sieve removes wheat bran, and it is stand-by crude drug to be ground to form smalls;
(4) calcium gluconate tablet, colchicines tablets and the vitamin B slender roll of medicated paper or gauze are pulverized; add the boiled water of calcium gluconate tablet, colchicines tablets and vitamin B5-10 times; soak 5-10 hour; add step (1)-(3) gained smalls; little fire is heated to boiling; stir; change slow fire boiling 30-50 hour; leave standstill 12-16 hour; get supernatant, supernatant is boiled and adds white sugar to boiling, cease fire after white sugar melts fully completely; cool rear bottling and namely obtain oral medicine, residue medicinal residues are bottled and obtain external smearing ointment.
The preparation method of foregoing compositions, step (1) smalls crosses 90-110 mesh sieve stand-by (preferred, it is stand-by that smalls crosses 100 mesh sieves).
The preparation method of foregoing compositions, Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar soaks 8-13 hour (preferred, Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar are soaked 10 hours) by step (2).
The preparation method of foregoing compositions, step (2) steams 25-35 minute (preferred, to steam 30 minutes).
The preparation method of foregoing compositions, step (3) drops into the crude drug cut, and stir-fry 5-7 minute (preferred, to drop into the crude drug cut, stir-fry fast 6 minutes) fast.
The preparation method of foregoing compositions, step (4) adds the boiled water of calcium gluconate tablet, colchicines tablets and vitamin B6-9 times, soak 6-9 hour (preferred, to add calcium gluconate tablet, colchicines tablets and vitamin B7 .5 boiled water doubly, soak 8 hours).
The preparation method of foregoing compositions, step (4) little fire is heated to boiling, stirs, change slow fire boiling 35-45 hour, (preferred, little fire is heated to boiling to leave standstill 13-15 hour, stir, change slow fire boiling 40 hours, leave standstill 14 hours).
Using method: for making the present invention reach optimum therapeuticing effect, three get oral medicine 3-5ml of the present invention, warm water delivery service after the meal, and external smearing ointment spreads upon affected part, wraps with bundle, and using once before sleep every night, 7 days is a course for the treatment of.
Said composition is to the Be very effective for the treatment of the pain caused by femur head necrosis, the Chinese medicine of Chinese medicine employing blood circulation promoting and blood stasis dispelling of the present invention, relaxing muscles and tendons and activating QI and blood in the collateral, QI invigorating pain relieving, strong bone of enriching blood and analgesic antiphlogistic are good for the Western medicine of bone, reasonable compatibility, improve body immunity, have no side effect, improve the body constitution of patient's weakness because of chronic pain, and the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
Treat the composition and method of making the same of the pain caused by femur head necrosis, the pharmacological effect of each crude drug is respectively:
Carapax et Plastrum Testudinis: YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone.Control deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spit blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.
Calcium gluconate tablet: calcium gluconate tablet, indication is for prevention and therapy calcium deficiency, as osteoporosis, tetany disease, dysosteogenesis, rickets and child, gestation and women breast-feeding their children, menopausal women, the supplementing of old people's calcium.
Flos Carthami: pungent, temperature, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contributes to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection swells and ache curative effect.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen, and avoids anemia of pregnant woman to use, otherwise can cause miscarriage.
Herba speranskiae tuberculatae: sweet, acrid, warm, enters lung, liver two warp, expelling wind and removing dampness, the pungent temperature of these product, Xin Nenghang falls apart, temperature overcomes the coldness wet, relaxing muscles and tendons and activating QI and blood in the collateral, and the pungent loose temperature of these product is led to, enter Liver Channel, and liver governing tendons. therefore these product have effect of relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain, the pungent loose temperature of these product is led to, enter Liver Channel blood system, therefore energy promoting blood circulation and stopping pain, solution poisons rash.
Cortex Acanthopancis: nature and flavor acrid in the mouth, hardship, warm in nature.Gui Jing: liver, kidney channel.Function has wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, the effect of inducing diuresis to remove edema.Cure mainly: for Bi condition, muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, beriberi.
Herba Hedyotidis Diffusae: another name: Herba Hedyotidis Diffusae, tang Huang, Serpentis needle grass, Radix Picriae felterrae, two leaf humulus, spend that cross grass, sharp knife grass, JIAMENGCAO, Herba Otteliae Alismoidis, Serpentis Lei are careless, crane SHECAO in vain, cures mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Be good at the multiple cancerous protuberance for the treatment of, herb controls infantile malnutrition, headache, nephritis, appendicitis, liver cirrhosis.
Myrrha: cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.Be in the Orient a kind ofly to invigorate blood circulation, blood stasis dispelling, pain relieving, stomach invigorating Chinese medicine.
Rhizoma Homalomenae: nature and flavor: bitter in the mouth, pungent, warm in nature.Gui Jing: liver, kidney channel.Function: have wind-damp dispelling, effect of strengthening bone and muscle.Cure mainly: for anemofrigid-damp arthralgia, chills and pain of the waist and kness, contracture is numb, and muscles and bones flaccidity is soft.
Colchicines tablets: colchicines tablets, indication is the acute attack for the treatment of gouty arthritis, the acute attack of prevention of recurrence gouty arthritis.
Radix Notoginseng: sweet, micro-hardship, temperature.Gui Jing returns liver, stomach warp.Effect dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly for spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
Rhizoma Chuanxiong: activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Rhizoma Corydalis: acrid in the mouth, hardship, warm in nature.There is promoting blood circulation to remove blood stasis, the function of promoting the circulation of QI pain relieving.For whole body each portion qi depression to blood stasis pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.
Radix Angelicae Pubescentis: nature and flavor: acrid in the mouth, hardship, slightly warm in nature.Gui Jing: return kidney, urinary bladder channel.Effect: expelling wind and removing dampness, arthralgia aggravated by cold pain relieving.
Cure mainly: for anemofrigid-damp arthralgia, wash pain, few cloudy volt wind headache, wind and cold holds wet headache under the arm.
Rhizoma Drynariae: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.The kidney invigorating, invigorates blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.
Vitamin B: the most frequent member of vitamin B extended familys has B1.B2.B3(nicotinic acid), B5(pantothenic acid), B6.B9(folic acid) B12(cobalamine).Their effect is described below.1. are critical materials in carbohydrate metabolism process.Muscle and the neural institute energy requirement of health provide primarily of saccharide, so the most easily get involved.VB is sufficient, then neurocyte energetic, can alleviate worry, anxiety, increases the holding capacity to noise etc.; Otherwise, cause the ability of answering pressure to fail, even cause neuritis.Cardiac function is influenced due to the deposition of acetone acid, lactic acid.The deficient scarce energy of the intestines and stomach, wriggles unable, digestive function weakness, and produces constipation.Vitamin B1 deficiency is caused time serious.Its evolutionary process is: body void-tired-irritated, depressed-constipation-neuritis-pained-heart failure-edema.Dutch doctor in 1897 finds that edible polished rice can cause vitamin B1 deficiency.Mainly in default of vitamin B1, so B1 is also called anti beriberi vitamin.Diet very important 2. is closely related with the metabolism of sugar, protein, fat.Maintain and improve epithelial tissue, as the epithelial tissue of eyes, the health of alimentary canal mucous membrane tissue.Asthenopia, conjunctival hyperemia, angular cheilitis etc. are had during famine.When angular cheilitis doctor usually can want patient to take riboflavin, namely B2.3. the bad meeting of lipid metabolism causes seborrheic dermatitis, small pox, acne, and vitimin supplement B has good effect.4. lack B race so that gastrointestinal peristalsis is unable, digestive juice secretion is bad, causes dyspepsia, constipation, halitosis, stool cacosmia.5.B3 form the coenzyme of dehydrogenase in vivo, play an important role in the metabolism of carbohydrate, protein, fat, cause nerve, skin, Alimentary tract disease during famine, be called pellagra, also cry three D diseases, show as dermatitis, diarrhoea and dementia.6. help bodily tissue to utilize oxygen, what promote skin, fingernail, hair tissue obtains oxygen amount, dispels or improves the dandruff.7. the toxin such as relieving alcohol and nicotine, releive headache, migraine, the liver protecting.The shortage of 8.B11.B12 by affect thymus pyrimidine, purine, etc. synthesis, cause DNA dyssynthesis.Finally cause erythrocytic nucleus immature, generate ineffectivity erythrocyte, Here it is megaloblastic anemia.9. as lacked folic acid at conceived in 3 months, can Fetal neurotubules malformation be caused, thus increase and split animal brains, the incidence rate of anencephaly.10.B vitamin (mainly vitamin B1) has a kind of special abnormal smells from the patient, is the vitamin that mosquito is detested, thus has repelling effect to a certain degree.
The principle of the pain that the present composition is caused by femur head necrosis based on traditional Chinese medical herbal treatment, the existing benefiting qi and nourishing blood of the Chinese medicinal material selected, regulating the flow of Qi and the middle Jiao, relaxing muscles and tendons to promote blood circulation, strong muscle key bone, treat effect of the pain caused by femur head necrosis, Chinese medicine and Western medicine are mixed the compositions being prepared into and treating the pain caused by femur head necrosis, cheap, life-time service also can not cause the financial burden of patient, is to treat the ideal medicine of the pain that caused by femur head necrosis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat the compositions of the pain caused by femur head necrosis, each crude drug is as follows, is weight portion (getting 10g for every part): Carapax et Plastrum Testudinis 1, calcium gluconate tablet 2, Flos Carthami 3, Herba speranskiae tuberculatae 2, Cortex Acanthopancis 4, Herba Hedyotidis Diffusae 10, Myrrha 5, Rhizoma Homalomenae 5, colchicines tablets 2, Radix Notoginseng 4, Rhizoma Chuanxiong 10, Rhizoma Corydalis 5, Radix Angelicae Pubescentis 6, Rhizoma Drynariae 3, vitaminB10.
The preparation method of the compositions of the pain that above-mentioned treatment is caused by femur head necrosis, step is:
(1) dry clean for Carapax et Plastrum Testudinis, pinion with iron wire, big fire bake is crisp, grinds to form smalls, crosses 80 mesh sieves stand-by;
(2) Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar are soaked 5 hours, steam 20 minutes, dryouied by large iron pan, rapidly drop into steamed crude drug, parch is flavoursome when sending, and cools, and to cross 80 mesh sieves for subsequent use for pulverization altogether;
(3) Herba Hedyotidis Diffusae, Myrrha, Rhizoma Homalomenae, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis and Rhizoma Drynariae are cleaned, dry, be cut into small pieces, be placed in by wheat bran in marmite, the sliding sharp state of parch, drops into the crude drug cut, stir-fry fast 4 minutes, sieve removes wheat bran, and it is stand-by crude drug to be ground to form smalls;
(4) calcium gluconate tablet, colchicines tablets and the vitamin B slender roll of medicated paper or gauze are pulverized; add calcium gluconate tablet, colchicines tablets and vitamin B5 boiled water doubly; soak 5 hours; add step (1)-(3) gained smalls; little fire is heated to boiling; stir; change slow fire boiling 30 hours; leave standstill 12 hours; get supernatant, supernatant is boiled and adds white sugar to boiling, cease fire after white sugar melts fully completely; cool rear bottling and namely obtain oral medicine, residue medicinal residues are bottled and obtain external smearing ointment.
embodiment 2treat the compositions of the pain caused by femur head necrosis, each crude drug is as follows, is weight portion (getting 15g for every part): Carapax et Plastrum Testudinis 5, calcium gluconate tablet 4, Flos Carthami 7, Herba speranskiae tuberculatae 6, Cortex Acanthopancis 8, Herba Hedyotidis Diffusae 15, Myrrha 15, Rhizoma Homalomenae 10, colchicines tablets 4, Radix Notoginseng 8, Rhizoma Chuanxiong 20, Rhizoma Corydalis 15, Radix Angelicae Pubescentis 16, Rhizoma Drynariae 9, VB14.
The preparation method of the compositions of the pain that above-mentioned treatment is caused by femur head necrosis, step is:
(1) dry clean for Carapax et Plastrum Testudinis, pinion with iron wire, big fire bake is crisp, grinds to form smalls, crosses 120 mesh sieves stand-by;
(2) Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar are soaked 15 hours, steam 40 minutes, dryouied by large iron pan, rapidly drop into steamed crude drug, parch is flavoursome when sending, and cools, and to cross 120 mesh sieves for subsequent use for pulverization altogether;
(3) Herba Hedyotidis Diffusae, Myrrha, Rhizoma Homalomenae, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis and Rhizoma Drynariae are cleaned, dry, be cut into small pieces, be placed in by wheat bran in marmite, the sliding sharp state of parch, drops into the crude drug cut, stir-fry fast 8 minutes, sieve removes wheat bran, and it is stand-by crude drug to be ground to form smalls;
(4) calcium gluconate tablet, colchicines tablets and the vitamin B slender roll of medicated paper or gauze are pulverized; add calcium gluconate tablet, colchicines tablets and vitaminB10 boiled water doubly; soak 10 hours; add step (1)-(3) gained smalls; little fire is heated to boiling; stir; change slow fire boiling 50 hours; leave standstill 16 hours; get supernatant, supernatant is boiled and adds white sugar to boiling, cease fire after white sugar melts fully completely; cool rear bottling and namely obtain oral medicine, residue medicinal residues are bottled and obtain external smearing ointment.
typical case one:zhu XX, man, 59 years old is a machine-operated retired cadre, traffic accident before 2 years, the serious crush injury that caused right lower limb to be subject to, and occurred waist mild pain afterwards, right hip joint starts pain gradually.Be femoral head right lateral thigh head necrosis to examination in hospital.Give other treatments by Chinese herbs three months, arthralgia is serious all the more, and both legs are more dumb, and follow up a case by regular visits to and recur, doctor advised takes the present composition.
Use and coordinate embodiment 2 resulting composition, after three courses for the treatment of, arthralgia disappears, and both legs are also flexible, and sleep also obviously improves, and after 7 courses for the treatment of, the symptom of patient all disappears.
embodiment 3treat the compositions of the pain caused by femur head necrosis, each crude drug is as follows, is weight portion (getting 20g for every part): Carapax et Plastrum Testudinis 2, calcium gluconate tablet 2.5, Flos Carthami 4, Herba speranskiae tuberculatae 4, Cortex Acanthopancis 5, Herba Hedyotidis Diffusae 11, Myrrha 8, Rhizoma Homalomenae 6, colchicines tablets 2.5, Radix Notoginseng 5, Rhizoma Chuanxiong 13, Rhizoma Corydalis 8, Radix Angelicae Pubescentis 10, Rhizoma Drynariae 5, VB11.
The preparation method of the compositions of the pain that above-mentioned treatment is caused by femur head necrosis, step is:
(1) dry clean for Carapax et Plastrum Testudinis, pinion with iron wire, big fire bake is crisp, grinds to form smalls, crosses 90 mesh sieves stand-by;
(2) Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar are soaked 8 hours, steam 25 minutes, dryouied by large iron pan, rapidly drop into steamed crude drug, parch is flavoursome when sending, and cools, and to cross 90 mesh sieves for subsequent use for pulverization altogether;
(3) Herba Hedyotidis Diffusae, Myrrha, Rhizoma Homalomenae, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis and Rhizoma Drynariae are cleaned, dry, be cut into small pieces, be placed in by wheat bran in marmite, the sliding sharp state of parch, drops into the crude drug cut, stir-fry fast 5 minutes, sieve removes wheat bran, and it is stand-by crude drug to be ground to form smalls;
(4) calcium gluconate tablet, colchicines tablets and the vitamin B slender roll of medicated paper or gauze are pulverized; add calcium gluconate tablet, colchicines tablets and vitamin B6 boiled water doubly; soak 6 hours; add step (1)-(3) gained smalls; little fire is heated to boiling; stir; change slow fire boiling 35 hours; leave standstill 13 hours; get supernatant, supernatant is boiled and adds white sugar to boiling, cease fire after white sugar melts fully completely; cool rear bottling and namely obtain oral medicine, residue medicinal residues are bottled and obtain external smearing ointment.
embodiment 4treat the compositions of the pain caused by femur head necrosis, each crude drug is as follows, is weight portion (getting 25g for every part): Carapax et Plastrum Testudinis 4, calcium gluconate tablet 3.5, Flos Carthami 6, Herba speranskiae tuberculatae 6, Cortex Acanthopancis 7, Herba Hedyotidis Diffusae 14, Myrrha 13, Rhizoma Homalomenae 9, colchicines tablets 3.5, Radix Notoginseng 7, Rhizoma Chuanxiong 18, Rhizoma Corydalis 13, Radix Angelicae Pubescentis 12, Rhizoma Drynariae 7, orotic acid.
The preparation method of the compositions of the pain that above-mentioned treatment is caused by femur head necrosis, step is:
(1) dry clean for Carapax et Plastrum Testudinis, pinion with iron wire, big fire bake is crisp, grinds to form smalls, crosses 110 mesh sieves stand-by;
(2) Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar are soaked 13 hours, steam 35 minutes, dryouied by large iron pan, rapidly drop into steamed crude drug, parch is flavoursome when sending, and cools, and to cross 110 mesh sieves for subsequent use for pulverization altogether;
(3) Herba Hedyotidis Diffusae, Myrrha, Rhizoma Homalomenae, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis and Rhizoma Drynariae are cleaned, dry, be cut into small pieces, be placed in by wheat bran in marmite, the sliding sharp state of parch, drops into the crude drug cut, stir-fry fast 7 minutes, sieve removes wheat bran, and it is stand-by crude drug to be ground to form smalls;
(4) calcium gluconate tablet, colchicines tablets and the vitamin B slender roll of medicated paper or gauze are pulverized; add calcium gluconate tablet, colchicines tablets and FA boiled water doubly; soak 9 hours; add step (1)-(3) gained smalls; little fire is heated to boiling; stir; change slow fire boiling 45 hours; leave standstill 15 hours; get supernatant, supernatant is boiled and adds white sugar to boiling, cease fire after white sugar melts fully completely; cool rear bottling and namely obtain oral medicine, residue medicinal residues are bottled and obtain external smearing ointment.
typical case two:zheng XX, man, 62 years old, there is left hip and the heating of the left gonalgia, meet the cold cloudy day, exacerbation of symptoms, gradually to fl place pain, increase the weight of time movable, left hip and the left gonalgia generate heat more than 3 years, through being diagnosed as the pain that left femoral head necrosis causes, doctor advised takes the present composition.
Use and coordinate embodiment 4 resulting composition, giving a Chinese medicine of the present invention month symptom and obviously alleviate, treat 3 months transference cures, taking the photograph sheet contrast fl skull matter and recover.
embodiment 5treat the compositions of the pain caused by femur head necrosis, each crude drug is as follows, is weight portion (getting 30g for every part): Carapax et Plastrum Testudinis 3, calcium gluconate tablet 3, Flos Carthami 5, Herba speranskiae tuberculatae 5, Cortex Acanthopancis 6, Herba Hedyotidis Diffusae 13, Myrrha 10, Rhizoma Homalomenae 7.5, colchicines tablets 3, Radix Notoginseng 6, Rhizoma Chuanxiong 15, Rhizoma Corydalis 10, Radix Angelicae Pubescentis 11, Rhizoma Drynariae 6, vitamin B12.
The preparation method of the compositions of the pain that above-mentioned treatment is caused by femur head necrosis, step is:
(1) dry clean for Carapax et Plastrum Testudinis, pinion with iron wire, big fire bake is crisp, grinds to form smalls, crosses 100 mesh sieves stand-by;
(2) Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar are soaked 10 hours, steam 30 minutes, dryouied by large iron pan, rapidly drop into steamed crude drug, parch is flavoursome when sending, and cools, and to cross 100 mesh sieves for subsequent use for pulverization altogether;
(3) Herba Hedyotidis Diffusae, Myrrha, Rhizoma Homalomenae, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis and Rhizoma Drynariae are cleaned, dry, be cut into small pieces, be placed in by wheat bran in marmite, the sliding sharp state of parch, drops into the crude drug cut, stir-fry fast 6 minutes, sieve removes wheat bran, and it is stand-by crude drug to be ground to form smalls;
(4) calcium gluconate tablet, colchicines tablets and the vitamin B slender roll of medicated paper or gauze are pulverized; add calcium gluconate tablet, colchicines tablets and vitamin B7 .5 boiled water doubly; soak 8 hours; add step (1)-(3) gained smalls; little fire is heated to boiling; stir; change slow fire boiling 40 hours; leave standstill 14 hours; get supernatant, supernatant is boiled and adds white sugar to boiling, cease fire after white sugar melts fully completely; cool rear bottling and namely obtain oral medicine, residue medicinal residues are bottled and obtain external smearing ointment.
experimental example (embodiment 5 resulting composition):in order to verify the effect of the present composition, we have extracted 400 patients in 4 hospitals and have carried out the experiment of medicine, test group 200 people, matched group 200 people, experimental group uses embodiment 5 resulting composition, and matched group uses other treatment to treat the medicine of the pain caused by femur head necrosis.Inclusion criteria: through being diagnosed as the pain patients that femur head necrosis causes, the pain clinical symptoms having femur head necrosis to cause is one or more.Using method: for making the present invention reach optimum therapeuticing effect, three get oral medicine 3-5ml of the present invention, warm water delivery service after the meal, and external smearing ointment spreads upon affected part, wraps with bundle, and using once before sleep every night, 7 days is a course for the treatment of.Curative effect situation criterion: 1, cure, after using this product, malaise symptoms disappears completely; 2, effective, after using this product, malaise symptoms alleviates or partial disappearance; 3, invalid, after using this product, malaise symptoms is unchanged.We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table:
Table 1: two groups of Clinical efficacy comparison [example] tables 1
Self-induction symptom and emotion changes result are as table 2:
Table 2:
Prove through clinical trial, the present composition is being treated in the pain caused by femur head necrosis, and effective percentage is 98%, and thoroughly can remove old complaint, treating both the principal and secondary aspects of a disease, makes the recovery from illness that patient is real; And any burden can not be caused to the health of patient.Present composition instant effect, can reach the object alleviating rapidly patient's misery, and relapse rate is low, is that the composition and method of making the same of the pain caused by femur head necrosis is treated in a kind for the treatment of safely and effectively.
Treat the composition and method of making the same of the pain caused by femur head necrosis, wherein Rhizoma Chuanxiong, Radix Angelicae Pubescentis do monarch, and ministerial drug is Herba Hedyotidis Diffusae, Myrrha and Rhizoma Corydalis, and remaining is adjuvant drug; Monarch drug carries attending effectiveness in the present invention, the effect of the pain all having benefiting qi and nourishing blood, relaxing muscles and tendons to promote blood circulation, by force muscle key bone-specific drug to be caused by femur head necrosis; Ministerial drug is the medicine that auxiliary monarch drug strengthens the main disease for the treatment of and main symptom; Adjuvant drug treatment is held concurrently disease, slows down the strong of monarch drug and ministerial drug; Medicine is made to play a part guiding drug.
Claims (10)
1. treat the compositions of the pain caused by femur head necrosis, it is characterized in that: each crude drug is as follows, is weight portion: Carapax et Plastrum Testudinis 1-5, calcium gluconate tablet 2-4, Flos Carthami 3-7, Herba speranskiae tuberculatae 2-6, Cortex Acanthopancis 4-8, Herba Hedyotidis Diffusae 10-15, Myrrha 5-15, Rhizoma Homalomenae 5-10, colchicines tablets 2-4, Radix Notoginseng 4-8, Rhizoma Chuanxiong 10-20, Rhizoma Corydalis 5-15, Radix Angelicae Pubescentis 6-16, Rhizoma Drynariae 3-9, vitaminB10-14.
2. the compositions of pain that caused by femur head necrosis for the treatment of according to claim 1, is characterized in that: each crude drug is as follows, is weight portion: Carapax et Plastrum Testudinis 2-4, calcium gluconate tablet 2.5-3.5, Flos Carthami 4-6, Herba speranskiae tuberculatae 4-6, Cortex Acanthopancis 5-7, Herba Hedyotidis Diffusae 11-14, Myrrha 8-13, Rhizoma Homalomenae 6-9, colchicines tablets 2.5-3.5, Radix Notoginseng 5-7, Rhizoma Chuanxiong 13-18, Rhizoma Corydalis 8-13, Radix Angelicae Pubescentis 10-12, Rhizoma Drynariae 5-7, VB11-13.
3. the compositions of pain that caused by femur head necrosis for the treatment of according to claim 1, is characterized in that: each crude drug is as follows, is weight portion: Carapax et Plastrum Testudinis 3, calcium gluconate tablet 3, Flos Carthami 5, Herba speranskiae tuberculatae 5, Cortex Acanthopancis 6, Herba Hedyotidis Diffusae 13, Myrrha 10, Rhizoma Homalomenae 7.5, colchicines tablets 3, Radix Notoginseng 6, Rhizoma Chuanxiong 15, Rhizoma Corydalis 10, Radix Angelicae Pubescentis 11, Rhizoma Drynariae 6, vitamin B12.
4. the preparation method of the compositions of the pain that the treatment according to any one of claim 1-3 is caused by femur head necrosis, is characterized in that: step is as follows:
(1) dry clean for Carapax et Plastrum Testudinis, pinion with iron wire, big fire bake is crisp, grinds to form smalls, crosses 80-120 mesh sieve stand-by;
(2) Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar is soaked 5-15 hour, steam 20-40 minute, dryouied by large iron pan, rapidly drop into steamed crude drug, parch is flavoursome when sending, and cools, and to cross 80-120 mesh sieve for subsequent use for pulverization altogether;
(3) Herba Hedyotidis Diffusae, Myrrha, Rhizoma Homalomenae, Radix Notoginseng, Rhizoma Chuanxiong, Rhizoma Corydalis and Rhizoma Drynariae are cleaned, dry, be cut into small pieces, be placed in by wheat bran in marmite, the sliding sharp state of parch, drops into the crude drug cut, stir-fry 4-8 minute fast, and sieve removes wheat bran, and it is stand-by crude drug to be ground to form smalls;
(4) calcium gluconate tablet, colchicines tablets and the vitamin B slender roll of medicated paper or gauze are pulverized; add the boiled water of calcium gluconate tablet, colchicines tablets and vitamin B5-10 times; soak 5-10 hour; add step (1)-(3) gained smalls; little fire is heated to boiling; stir; change slow fire boiling 30-50 hour; leave standstill 12-16 hour; get supernatant, supernatant is boiled and adds white sugar to boiling, cease fire after white sugar melts fully completely; cool rear bottling and namely obtain oral medicine, residue medicinal residues are bottled and obtain external smearing ointment.
5. the preparation method of compositions according to claim 4, is characterized in that: step (1) smalls crosses 90-110 mesh sieve stand-by (preferred, it is stand-by that smalls crosses 100 mesh sieves).
6. the preparation method of compositions according to claim 4, it is characterized in that: Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar soak 8-13 hour (preferred, Flos Carthami, Herba speranskiae tuberculatae, Cortex Acanthopancis and Radix Angelicae Pubescentis white vinegar are soaked 10 hours) by step (2).
7. the preparation method of compositions according to claim 4, is characterized in that: step (2) steams 25-35 minute (preferred, to steam 30 minutes).
8. the preparation method of compositions according to claim 4, is characterized in that: step (3) drops into the crude drug cut, and stir-fry 5-7 minute (preferred, to drop into the crude drug cut, stir-fry fast 6 minutes) fast.
9. the preparation method of compositions according to claim 4, it is characterized in that: step (4) adds the boiled water of calcium gluconate tablet, colchicines tablets and vitamin B6-9 times, soak 6-9 hour (preferably, add calcium gluconate tablet, colchicines tablets and vitamin B7 .5 boiled water doubly, soak 8 hours).
10. the preparation method of compositions according to claim 4, it is characterized in that: step (4) little fire is heated to boiling, stir, change slow fire boiling 35-45 hour, (preferred, little fire is heated to boiling, stirs to leave standstill 13-15 hour, change slow fire boiling 40 hours, leave standstill 14 hours).
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856445A (en) * | 2010-06-02 | 2010-10-13 | 苏娟 | Chinese patent medicament pills for treating femoral head necrosis |
| CN102327407A (en) * | 2011-09-30 | 2012-01-25 | 汪盘永 | Traditional Chinese medicine for treating femoral head necrosis and preparation method thereof |
| CN103768309A (en) * | 2012-10-24 | 2014-05-07 | 孙琼鹏 | Traditional Chinese medicine for treatment of femoral head necrosis |
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- 2015-03-09 CN CN201510101073.4A patent/CN104606413A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856445A (en) * | 2010-06-02 | 2010-10-13 | 苏娟 | Chinese patent medicament pills for treating femoral head necrosis |
| CN102327407A (en) * | 2011-09-30 | 2012-01-25 | 汪盘永 | Traditional Chinese medicine for treating femoral head necrosis and preparation method thereof |
| CN103768309A (en) * | 2012-10-24 | 2014-05-07 | 孙琼鹏 | Traditional Chinese medicine for treatment of femoral head necrosis |
Non-Patent Citations (1)
| Title |
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| 刘云峣 等: "《中国历代中医格言大观》", 31 March 1992, 文匯出版社 * |
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Application publication date: 20150513 |