CN104606068A - Anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion - Google Patents
Anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion Download PDFInfo
- Publication number
- CN104606068A CN104606068A CN201510067151.3A CN201510067151A CN104606068A CN 104606068 A CN104606068 A CN 104606068A CN 201510067151 A CN201510067151 A CN 201510067151A CN 104606068 A CN104606068 A CN 104606068A
- Authority
- CN
- China
- Prior art keywords
- carnosine
- glutathion
- cosmetics
- sunscreen
- biologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention provides an anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion. A cosmetic comprises the following components in percentage by weight: 0.1-20% of biologically active peptide and 1-30% of a sun-screening agent, wherein the biologically active peptide comprises dipeptide and tripeptide with antioxidant activity, dipeptide is carnosine, and tripeptide is one or more of glutathione, synthesized tripeptide phenylalanine-lysine-leucine and collagen tripeptide. According to the anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion provided by the invention, dipeptide and tripeptide with the antioxidant activity are combined to be taken as the biologically active peptide for removing free radicals in the body, and the biologically active peptide is effectively combined with the non-biologically-active sun-screening agent to ensure that the skins can be protected from ultraviolet radiation and the damages of the free radicals to the skins can be eliminated.
Description
Technical field
The present invention relates to cosmetic field, specifically, relate to the emulsion of a kind of antioxidant activity oligopeptide and sunscreen coupling.
Background technology
After skin accepts ultraviolet overexposure, meeting lesional epidermis cell; Activation Tyrosinase, accelerates pigment synthesis, destroys the moisture-keeping functions of skin, makes skin become dry, makes the elastic fibers in skin corium impaired, microgroove is produced.Under acute irradiation, also can cause skin inflammation, burn.When having abnormal case, then can become pigmentosa skin carcinoma etc.
Sunscreen cream kind is more in the market, is mainly reflected on sun-screening function, generally in out using, but be not suitable for when indoor using, because common sunscreen frost does not moisten and maintenance effect skin, coating time is oversize, increase skin loadings, skin is tarnished.
Publication number is that the Chinese patent application of CN103211717A discloses a kind of antioxidant composition, its composition comprises: an active powder, and it is selected from one in vitamin C, vitamin C derivant, Arbutin, Arbutin derivant, few victory peptide powder (as the sweet peptide of Grains Guang, carnosine etc.) to several; One solvent, it is selected from one in polyalcohols, ethanol, ethyoxyl ethylene glycol, ethyoxyl ethylene glycol derivative to several; And a selectivity additive, in the material that it is selected from the material of tool non-oxidizability, tool captures free radical, the material of tool metal-chelating, tool UV substance having sun-screening function one to several; By above composition, the active ingredient in active powder is first mixed with solvent, and the infiltration of aqueous vapor can be completely cut off, effectively slow down the situation of its oxidation flavescence; Allow user be used on skin by its antioxidant composition again, then can reach and improve skin speckle and obscure effect.
Summary of the invention
In order to solve problems of the prior art; the object of this invention is to provide the emulsion of a kind of antioxidant activity oligopeptide and sunscreen coupling; by antioxidant activity oligopeptide and sunscreen conbined usage; eliminates free radical (oligopeptide of antioxidant activity) dual purpose in the ultraviolet protection (sunscreen) realizing abiotic activity and body, the damage better protecting skin to avoid ultraviolet and the free radical that generates thus to cause.
In order to realize the object of the invention, technical scheme of the present invention is as follows:
Cosmetics for antioxidant activity oligopeptide and sunscreen coupling, described cosmetics contain biologically active peptide, and described biologically active peptide is dipeptides and the tripeptides with antioxidant activity; Wherein, described dipeptides is carnosine; Described tripeptides is selected from one or more in glutathion, synthesis tripeptides Phe-Lys-leucine, collagen tripeptide.
As preferably, described biologically active peptide is made up of carnosine, glutathion and collagen tripeptide.
Further, the content of described biologically active peptide is 0.1 ~ 10%.
As preferably, the content of described biologically active peptide is 0.5 ~ 5%.
Further, described cosmetics are also containing sunscreen, and the content of described sunscreen is 1 ~ 30%.
As preferably, the content of described sunscreen is 3 ~ 20%.
Further, described sunscreen is selected from one or more in OctMet, octyl dimethyl p-aminobenzoic acid, OXYBENZONE, ethylhexyl salicylate, titanium dioxide, zinc oxide, Montmorillonitum.
Further, described cosmetics are the gel of antioxidant activity oligopeptide and sunscreen coupling, and by weight, it consists of:
| Title | Content (w/w, %) |
| Carnosine | 0.1～1 |
| Glutathion | 0.1～2 |
| Collagen tripeptide | 0～2 |
| Acritamer 940 (2% solution) | 20～40 |
| Methyl parahydroxybenzoate | 0.1～1 |
| Propylene glycol | 2～4 |
| Mineral oil | 3～10 |
| Hexadecanol | 0.5～2 |
| Propyl p-hydroxybenzoate | 0.05～0.2 |
| OctMet | 3～7.5 |
| Stearic acid | 2～5 |
| Triethanolamine | 0.2～1 |
| Water | Mend to 100; |
As preferably, it consists of:
| title | content (w/w, %) |
| carnosine | 0.5 |
| glutathion | 0.5 |
| acritamer 940 (2% solution) | 40 |
| methyl parahydroxybenzoate | 0.2 |
| propylene glycol | 2 |
| mineral oil | 5 |
| hexadecanol | 1.5 |
| propyl p-hydroxybenzoate | 0.1 |
| octMet | 5 |
| stearic acid | 3 |
| triethanolamine | 1 |
| water | mend to 100. |
Further, described cosmetics are the emulsion of antioxidant activity oligopeptide and sunscreen coupling, and by weight, it consists of:.
| Title | Content (w/w, %) |
| Carnosine | 0.1～1 |
| Collagen tripeptide | 0.1～2 |
| Glutathion | 0～2 |
| Glycerol | 3～8 |
| Acritamer 940 (2% solution) | 2～10 |
| Polyvinylpyrrolidone | 2～5 |
| Stearic acid | 2～5 |
| Isopropyl palmitate | 2～5 |
| OctMet | 2～7 |
| Hexadecanol | 0.5～2 |
| Polydimethylsiloxane | 0.1～2 |
| Be coated with carbon dioxide Muscovitum | 5～15 |
| Water | Mend to 100; |
As preferably, it consists of:
| title | content (w/w, %) |
| carnosine | 0.5 |
| collagen tripeptide | 1 |
| glutathion | 0.2 |
| glycerol | 4 |
| acritamer 940 (2% solution) | 4 |
| polyvinylpyrrolidone | 3 |
| stearic acid | 2 |
| isopropyl palmitate | 3.5 |
| octMet | 4 |
| hexadecanol | 0.5 |
| polydimethylsiloxane | 0.2 |
| be coated with carbon dioxide Muscovitum | 15 |
| water | mend to 100. |
Further, described cosmetics are the emulsion of antioxidant activity oligopeptide and sunscreen coupling, and by weight, it consists of:
| Title | Content (w/w, %) |
| Carnosine | 0.1～1 |
| Glutathion | 0.5～5 |
| Synthesis tripeptides Phe-Lys-leucine | 0.1～2 |
| Acritamer 940 (2% solution) | 10～30 |
| Annular dimethyl polysiloxane | 1～3 |
| Stearic acid | 1～3 |
| Parleam | 3～7 |
| OctMet | 3～7.5 |
| Ethylhexyl salicylate | 2～5 |
| OXYBENZONE | 3～7 |
| Propyl p-hydroxybenzoate | 0.05～1 |
| Triethanolamine | 0.2～1 |
| Water | Mend to 100; |
As preferably, it consists of:
| title | content (w/w, %) |
| carnosine | 0.5 |
| glutathion | 2 |
| synthesis tripeptides Phe-Lys-leucine | 1 |
| acritamer 940 (2% solution) | 15 |
| annular dimethyl polysiloxane | 2 |
| stearic acid | 1.5 |
| parleam | 3 |
| octMet | 7.5 |
| ethylhexyl salicylate | 5 |
| oXYBENZONE | 3 |
| propyl p-hydroxybenzoate | 0.1 |
| triethanolamine | 0.5 |
| water | mend to 100. |
Cosmetics of the present invention, wherein the consumption of water is as the criterion finally to make the total consumption of each component in cosmetic formulations reach 100%.
Beneficial effect of the present invention is:
The present invention will have dipeptides and the tripeptides combination of antioxidant activity, as the biologically active peptide eliminating interior free yl, with the sunscreen efficient combination of abiotic activity, while protection skin avoids ultraviolet radiation, eliminate the damage that radical pair skin causes.
In addition, emulsion serviceability of the present invention is good, and viscosity is suitable, has the skin effects (skin elasticity after use) after nourishing sense and moist feeling and use, and has good time stability.
Detailed description of the invention
Below with reference to embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment 1 is containing the gel of antioxidant activity oligopeptide
1, form
2, preparation method:
After B component being heated to 70 DEG C, under 3000rpm stirring condition, after stirring 15min, after being down to room temperature, under 600rpm stirring condition, add component A, continue to stir 3min, add component C, stir evenly and get final product.
Embodiment 2 is containing the emulsion of antioxidant activity oligopeptide
1, form
2, preparation method:
After B component being heated to 70 DEG C, under 3000rpm stirring condition, after stirring 15min, after being down to room temperature, under 600rpm stirring condition, add A, component C, continue to stir 3min, to obtain final product.
Embodiment 3 is containing the emulsion of antioxidant activity oligopeptide
1, form
2, preparation method:
B, component C are heated to 75 DEG C respectively, mixing, 3000rpm after system is down to room temperature, adds component A after stirring 15min under 600rpm stirring condition, continues to stir 3min, to obtain final product.
Experimental example 1 sun-proof result is tested
Test method: the pertinent regulations detected with reference to spf value in " milk hygiene specification " (version in 2002), slightly changes.30 healthy volunteers are chosen, each 15 of men and women in test, IV type skin (namely seldom tan severely, but easily tanned skin quality), unglazed allergies.30 volunteers are divided into 3 groups, often organize 10 people.
The product of sample 1-3 prepared by embodiment of the present invention 1-3;
Reference substance 11: the composition of reference example 1 and preparation method, unlike, the carnosine and glutathion that wherein play antioxidation are removed, appropriate section with vitamin E (antioxidant is commonly used in this area) polishing, all the other prescriptions and preparation method constant.
Reference substance 12: the composition of reference example 1 and preparation method, unlike, delete glutathion, retain other components, the content of carnosine is brought up to 1.0%, and preparation method is constant.
Reference substance 13: the composition of reference example 1 and preparation method, unlike, delete carnosine, retain other components, the content of glutathion is brought up to 1.0%, and preparation method is constant.
Reference substance 14: the composition of reference example 1 and preparation method, unlike, propylene glycol is changed to sorbitol, mineral oil is changed to Tween 80, retain other components, preparation method is constant.
Reference substance 21: the composition of reference example 2 and preparation method, unlike, remove wherein playing the carnosine of antioxidation, glutathion and collagen tripeptide, appropriate section with ascorbic acid (antioxidant is commonly used in this area) polishing, all the other prescriptions and preparation method constant.
Reference substance 22: the composition of reference example 2 and preparation method, unlike, delete carnosine, retain other components, the content of glutathion is brought up to 0.7%, and preparation method is constant.
Reference substance 23: the composition of reference example 2 and preparation method, unlike, delete collagen tripeptide, retain other components, the content of carnosine is brought up to 1.0%, the content of glutathion brings up to 0.7%, and preparation method is constant.
Reference substance 24: the composition of reference example 2 and preparation method, unlike, delete glutathion, retain other components, the content of carnosine is brought up to 0.7%, and preparation method is constant.
Reference substance 25: the composition of reference example 2 and preparation method, unlike, annular dimethyl polysiloxane is changed to propylene glycol, ethylhexyl salicylate is changed to Tween 80, retain other components, preparation method is constant.
Reference substance 31: the composition of reference example 3 and preparation method, unlike, remove wherein playing the carnosine of antioxidation, glutathion and synthesis tripeptides (Phe-Lys-leucine), appropriate section with vitamin A (antioxidant is commonly used in this area) polishing, all the other prescriptions and preparation method constant.
Reference substance 32: the composition of reference example 3 and preparation method, unlike, delete glutathion, retain other components, the content of carnosine is brought up to 1.5%, and the content of synthesis tripeptides (Phe-Lys-leucine) brings up to 2.0%, and preparation method is constant.
Reference substance 33: the composition of reference example 3 and preparation method, unlike, delete carnosine, retain other components, the content of glutathion is brought up to 2.5%, and preparation method is constant.
Reference substance 34: the composition of reference example 3 and preparation method, unlike, delete synthesis tripeptides (Phe-Lys-leucine), retain other components, the content of carnosine is brought up to 1.5%, and preparation method is constant.
Reference substance 35: the composition of reference example 3 and preparation method, unlike, hexadecanol is changed to sorbitol, isopropyl palmitate is changed to hexadecanol, retain other components, preparation method is constant.
Experimental result is in table 1:
The different sample spf value of table 1
Can be seen by table 1:
1, adopt biologically active peptide as the emulsion of antioxidant content, compared with using the reference substance of chemical antioxidant content, spf value significantly improves, and sun-proof result is more excellent.This is because biologically active peptide better can play non-oxidizability in living organism, produces antioxidation more rapidly.
2, combinationally use carnosine, glutathion and collagen tripeptide/synthesis tripeptides, with adopt single oligopeptide or done a little fine setting biologically active peptide reference substance compared with, spf value has advantage equally, and sun-proof result is more excellent.Illustrate, the present invention combinationally uses the antioxygenic property that carnosine, glutathion and collagen tripeptide/synthesis tripeptides better can play biologically active peptide.
In order to verify the ageing of ultra light sun block lotion of the present invention, after each sample above-mentioned is placed 6 months and 12 months respectively, repeat above-mentioned identical test method, detect the spf value of each sample, experimental result is in table 2:
Different sample spf value after 6 months and 12 months placed by table 2
Experimental example 2 MTT activity test
Take the logarithm the human epidermal cell HEK-n of trophophase, according to 1 × 10
5the concentration of cells/mL inoculates 96 orifice plates, every pore volume 200 μ L, after normal cultivation 24h, in protection group cell culture fluid, adds trial target respectively, after 5min, adopts 1mM H respectively
2o
2carry out oxidative damage process 6h.After oxidative damage process terminates, take out 96 well culture plates, abandon supernatant, after carefully rushing 2-3 time with PBS, then add the fresh medium of 200 μ L containing 0.5mg/mL MTT, continue, at 37 DEG C, under 5%CO condition, to cultivate 4h.After cultivation terminates, discard MTT solution, every hole adds 100 μ LDMSO, vibration mixing, surveys each hole absorbance (A490) that wavelength is 490nm, calculates cell survival rate, the results are shown in Table 3.
Trial target is with experimental example 1.
Table 3 MTT activity test
Can be seen by table 3:
1, adopt biologically active peptide as the emulsion of antioxidant content, compared with using the reference substance of chemical antioxidant content, cell survival rate significantly improves.This is because biologically active peptide better can play non-oxidizability in living organism, produces antioxidation more rapidly.
2, combinationally use carnosine, glutathion and collagen tripeptide/synthesis tripeptides, with adopt single oligopeptide or done a little fine setting biologically active peptide reference substance compared with, cell survival rate has advantage equally.Illustrate, the present invention combinationally uses the antioxygenic property that carnosine, glutathion and collagen tripeptide/synthesis tripeptides better can play biologically active peptide.
Experimental example 3 property pushed open and the evaluation test using rear skin
Test method: choose 30 healthy volunteers, each 15 of men and women, IV type skin (namely seldom tan severely, but easily tanned skin quality), unglazed allergies.30 volunteers are divided into 3 groups, often organize 10 people.Volunteer tries out trial target respectively, and gives a mark with using the skin (elasticity and humidity) of latter 3 hours for the property pushed open of emulsion, assembly average.
Trial target is with experimental example 1.
Experimental result is in table 4:
Table 4 volunteer is to the in-service evaluation of different sample
Can be seen by table 4:
Adopt the emulsion of biological activity peptide components, compared with using the reference substance of chemical antioxidant content, due to its composition laminating human body skin quality, be easy to skin absorb, what make emulsion pushes performance open better, when smearing use, more promptly can launch, and be easy to smear evenly, more attractive in appearance.In addition, needing to carry out in sun-proof environment, skin often easily dries out and nutrient, causes skin quality to be deteriorated, and adopts the emulsion of biological activity peptide components, better can keep skin elasticity, and does not rise glossy.
Experimental example 4 free radical scavenging is tested
Test principle: DPPH is a kind of stable free radical in organic solvent, and its lone pair electrons have strong absorption (aobvious darkviolet) near 517nm.When organic scavenger exists, lone pair electrons are paired, and absorb and disappear or weaken, and by measuring the degree absorbing and weaken, can evaluate the activity of free radical scavenger.
Test method: extracting sample solution 2mL and concentration are that the DPPH solution 2mL of 100 μm of oL/L successively adds in same tool plug test tube, shake up; Left at room temperature 30min, working sample absorbance under 517nm wavelength.
Suppression ratio: K%=[1-(Ai-Aj)/Ac] × 100%
The absorbance of Ai:2mLDPPH solution+2mL product to be tested solution
The absorbance of Aj:2mL product to be tested solution+2mL solvent
The absorbance of Ac:2mLDPPH solution+2mL solvent
Trial target is with experimental example 1.
Experimental result is in table 5:
The different sample of table 5 is to the clearance rate of DPPH
| Test group | DPPH clearance rate % |
| Sample 1 | 88.7 |
| Reference substance 11 | 30.4 |
| Reference substance 12 | 80.1 |
| Reference substance 13 | 81.5 |
| Reference substance 14 | 82.0 |
| Sample 2 | 89.4 |
| Reference substance 21 | 41.5 |
| Reference substance 22 | 81.9 |
| Reference substance 23 | 82.4 |
| Reference substance 24 | 82.6 |
| Reference substance 25 | 81.5 |
| Sample 3 | 90.2 |
| Reference substance 31 | 44.1 |
| Reference substance 32 | 84.1 |
| Reference substance 33 | 83.6 |
| Reference substance 34 | 84.7 |
| Reference substance 35 | 83.9 |
Can be seen by table 5:
1, adopt biologically active peptide as the emulsion of antioxidant content, compared with using the reference substance of chemical antioxidant content, the clearance rate of DPPH significantly improves.This is because biologically active peptide better can play non-oxidizability in living organism, produces antioxidation more rapidly.
2, combinationally use carnosine, glutathion and collagen tripeptide/synthesis tripeptides, with adopt single oligopeptide or done a little fine setting biologically active peptide reference substance compared with, the clearance rate of DPPH has advantage equally.Illustrate, the present invention combinationally uses the antioxygenic property that carnosine, glutathion and collagen tripeptide/synthesis tripeptides better can play biologically active peptide.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. cosmetics for antioxidant activity oligopeptide and sunscreen coupling, is characterized in that, described cosmetics contain biologically active peptide, and described biologically active peptide is dipeptides and the tripeptides with antioxidant activity; Wherein, described dipeptides is carnosine; Described tripeptides is selected from one or more in glutathion, synthesis tripeptides Phe-Lys-leucine, collagen tripeptide.
2. cosmetics according to claim 1, is characterized in that, described biologically active peptide is made up of carnosine, glutathion and collagen tripeptide.
3. cosmetics according to claim 1 and 2, is characterized in that, the content of described biologically active peptide is 0.1 ~ 20%.
4. cosmetics according to claim 3, is characterized in that, the content of described biologically active peptide is 0.5 ~ 10%.
5. cosmetics according to claim 3, is characterized in that, described cosmetics are also containing sunscreen, and the content of described sunscreen is 1 ~ 30%.
6. cosmetics according to claim 5, is characterized in that, the content of described sunscreen is 3 ~ 20%.
7. cosmetics according to claim 3, is characterized in that, described sunscreen is selected from one or more in OctMet, octyl dimethyl p-aminobenzoic acid, OXYBENZONE, ethylhexyl salicylate, titanium dioxide, zinc oxide, Montmorillonitum.
8. cosmetics according to claim 3, is characterized in that, described cosmetics are the gel of antioxidant activity oligopeptide and sunscreen coupling, and by weight, it consists of:
As preferably, it consists of:
9. cosmetics according to claim 3, is characterized in that, described cosmetics are the emulsion of antioxidant activity oligopeptide and sunscreen coupling, and by weight, it consists of:
As preferably, it consists of:
10. cosmetics according to claim 3, is characterized in that, described cosmetics are the emulsion of antioxidant activity oligopeptide and sunscreen coupling, and by weight, it consists of:
As preferably, it consists of:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510067151.3A CN104606068A (en) | 2015-02-06 | 2015-02-06 | Anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510067151.3A CN104606068A (en) | 2015-02-06 | 2015-02-06 | Anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104606068A true CN104606068A (en) | 2015-05-13 |
Family
ID=53140900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510067151.3A Pending CN104606068A (en) | 2015-02-06 | 2015-02-06 | Anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104606068A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434188A (en) * | 2015-12-29 | 2016-03-30 | 广州市科能化妆品科研有限公司 | Sunscreen cream and preparation method thereof |
| CN108430448A (en) * | 2015-12-15 | 2018-08-21 | 西姆莱斯股份公司 | Lotion containing UV sun protection factors and carnosine |
| CN108635274A (en) * | 2018-07-26 | 2018-10-12 | 广州环亚化妆品科技有限公司 | A kind of photoprotective composition and its preparation method and application |
| CN109475482A (en) * | 2016-03-21 | 2019-03-15 | 西姆莱斯股份公司 | Drug |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101686923A (en) * | 2007-07-06 | 2010-03-31 | 富士胶片株式会社 | Cosmetic composition |
| CN103961276A (en) * | 2014-01-08 | 2014-08-06 | 片仔癀（上海）生物科技研发有限公司 | Anti-glycation cosmetic composition and anti-glycation cosmetics containing same |
-
2015
- 2015-02-06 CN CN201510067151.3A patent/CN104606068A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101686923A (en) * | 2007-07-06 | 2010-03-31 | 富士胶片株式会社 | Cosmetic composition |
| CN103961276A (en) * | 2014-01-08 | 2014-08-06 | 片仔癀（上海）生物科技研发有限公司 | Anti-glycation cosmetic composition and anti-glycation cosmetics containing same |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108430448A (en) * | 2015-12-15 | 2018-08-21 | 西姆莱斯股份公司 | Lotion containing UV sun protection factors and carnosine |
| CN108430448B (en) * | 2015-12-15 | 2021-10-01 | 西姆莱斯股份公司 | Emulsion containing UV sun protection factor and carnosine |
| CN105434188A (en) * | 2015-12-29 | 2016-03-30 | 广州市科能化妆品科研有限公司 | Sunscreen cream and preparation method thereof |
| CN105434188B (en) * | 2015-12-29 | 2017-05-31 | 广州市科能化妆品科研有限公司 | Suncream and its preparation method |
| CN109475482A (en) * | 2016-03-21 | 2019-03-15 | 西姆莱斯股份公司 | Drug |
| CN109475482B (en) * | 2016-03-21 | 2022-03-29 | 西姆莱斯股份公司 | Medicine |
| CN108635274A (en) * | 2018-07-26 | 2018-10-12 | 广州环亚化妆品科技有限公司 | A kind of photoprotective composition and its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101588788B (en) | Cosmetic composition for protecting skin against uv light and wrinkle improvement containing the extract of magnolia sieboldii flower extracts | |
| CN110200875A (en) | A kind of antiallergic whitening mask and preparation method thereof | |
| CN108030718A (en) | A kind of sun-proof whitening and skin-protecting composition and preparation method thereof | |
| CN104606068A (en) | Anti-oxidative-activity oligopeptide and sun-screening agent combined emulsion | |
| CN105434327A (en) | Total-effect type skin-moistening sun cream | |
| CN109330954B (en) | Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor | |
| CN110234407A (en) | Peptide and composition for cosmetics | |
| KR100881143B1 (en) | Composition of skin external application containing green tea flower extract | |
| KR101915655B1 (en) | Cosmetic composition containing Croton Lechleri resin extract | |
| KR100992088B1 (en) | Cosmetic composition containing natural plant extracts with x-ray protecting effect | |
| KR101128591B1 (en) | Marine red algae extract mixture and cosmetic composition comprising the same | |
| CN108938479A (en) | A kind of mildy wash of the extract containing water lily and preparation method thereof | |
| CN104546530A (en) | UV (ultraviolet)-proof repair lotion containing biological active peptide | |
| KR100834484B1 (en) | Oil-type cosmetic composition comprising plant extract | |
| CN104606066A (en) | Photo damage resistance gel containing salidroside | |
| KR20080061080A (en) | Cosmetic composition comprising tuber melanosporum | |
| CN104873442A (en) | Sunscreen spray and preparation method thereof | |
| KR20120139005A (en) | Natural cosmetic composition, skin sheet and storage container comprising the same | |
| CN113384510B (en) | Fermented composition with anti-photoaging, relieving and cooling effects and preparation method and application thereof | |
| CN108158960A (en) | With the lip care lipstick for alleviating pigmentation | |
| CN104434557A (en) | Peptide composition with anti-oxidization effect as well as preparation method and application thereof | |
| CN109966191A (en) | A kind of bush cinqefoil flower extract and its new opplication | |
| CN112535657A (en) | Light protection repair composition, preparation method and application thereof, and skin care product | |
| KR102108116B1 (en) | A cosmetic composition comprising a natural component and an oil component | |
| CN104644504A (en) | Ultraviolet-proof moisturizing primer cream having good stability |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150513 |