CN104606066A - Photo damage resistance gel containing salidroside - Google Patents
Photo damage resistance gel containing salidroside Download PDFInfo
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- CN104606066A CN104606066A CN201510067098.7A CN201510067098A CN104606066A CN 104606066 A CN104606066 A CN 104606066A CN 201510067098 A CN201510067098 A CN 201510067098A CN 104606066 A CN104606066 A CN 104606066A
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Abstract
The invention provides a photo damage resistance gel containing salidroside. A cosmetic contains 5-50 percent of a salidroside lipid nano-emulsion and is capable of resisting damages to skin caused by environment (such as ultraviolet rays and air pollution) except the effects of repairing, moisturizing, resisting wrinkle and refirming. According to the photo damage resistance gel, with the lipid nano-emulsion as a carrier of eliminating the salidroside, serving as the bioactive components of free radicals in vivo, the absorption ratio of skin to the salidroside and the bioavailability of hydrophilic molecules are remarkably increased; with the combination of the salidroside lipid nano-emulsion, a non-bioactive sun-screening agent and a whitening agent, damage of the free radicals to the skin is effectively eliminated while the skin is protected from ultraviolet radiation, and the purposes of protecting the skin and resisting photo damage are achieved.
Description
Technical field
The present invention relates to cosmetic field, specifically, relate to a kind of photodamage resistant gel containing rhodioside.
Background technology
Ultraviolet in sunlight causes skin blackening and aging main cause, usually by resisting ultraviolet to the mode of dermal application sunscreen cream.The action principle of sunscreen cream is kept apart at skin and ultraviolet, thus prevent skin sunburn.Current sunscreen product on the market, main component is sunscreen, and whitening, antioxidant content are relatively less.
Radix Rhodiolae (Rhodiola rosea) is the herbaceos perennial of Crassulaceae rhodiola, and the applicating history of Radix Rhodiolae is long, and before more than 2,000 year, the people of Qinghai-Tibet Platean is just used as medicine with it, with building body, and the impact of opposing poor environment.Among the people being commonly used to is decocted water or steeps in wine, to banish fatigue or to resist mountain area cold.Simultaneously and diseases prevention is healthy and strong and nourishing lengthens one's life.Because it has magical effect of strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting.
Rhodioside (Salidroside) is the principle active component of Radix Rhodiolae, modern pharmacology research proves, rhodioside has antifatigue effect, resisting microwave radiation effect, suppresses the health cares such as blood glucose rising, Hardy dwarfing, be widely used in health product, beverage, and in cosmetics.Rhodioside molecular weight is 300Da, excellent aqueous solubility.But due to the lipid and cuticular existence of skin, hydrophilic molecule is difficult to be absorbed by body by skin barrier.
Publication number is that the Chinese patent application of CN104042484A discloses a kind of light ultra light sun block lotion, be made up of the raw material of following parts by weight: Radix Rhodiolae extract 2-4 part, stearic acid 2-5 part, liquid paraffin 10-15 part, polyoxyethylene 20 sorbitan monooleate 3-6 part, glycerol 7-14 part, behenyl alcohol 2-6 part, titanium dioxide 2-4 part, vaseline 5-15 part, Margarita powder 7-12 part, dimethicone 3-6 part, methyl hydroxybenzoate 2-6 part, squalane 1-4 part, collagen protein 3-7 part, hyaluronic acid 2-5 part, Herba bromi japonici polysaccharide 3-6 part.
Publication number is that the Chinese patent application of CN1686079A discloses a kind of sunscreen containing natural plant sunscreen component, is made up of (percentage by weight): Radix Rhodiolae extract 0.5 ~ 5.0, stearic acid 2.0 ~ 5.0, liquid paraffin 13 ~ 15, octadecanol 3.0 ~ 5.0, dimethicone 2.0 ~ 4.0, polyoxyethylene 20 sorbitan monooleate 3.0 ~ 5.0, glycerol 3.0 ~ 5.0, propylene glycol 3.0 ~ 5.0, ethyl hydroxybenzoate 0.2 ~ 0.4, triethanolamine 1.5, vitamin e acetate 0.1 ~ 0.2, essence 0.5 ~ 1.5, deionized water surplus following component.
Summary of the invention
In order to solve problems of the prior art, the object of this invention is to provide a kind of sunscreen product containing rhodioside, using lipid nanoemulsion as rhodioside carrier, hydrophilic molecule is wrapped in the amphipathic systems such as Emulsion, improve skin to the absorbance of rhodioside, significantly strengthen the bioavailability of hydrophilic molecules.
In order to realize the object of the invention, technical scheme of the present invention is as follows:
Containing photodamage resistant cosmetics for rhodioside, described cosmetics contain rhodioside lipid nanoemulsion, and by weight percentage, described rhodioside lipid nanometer milk content is 5 ~ 50%; Preferably, described rhodioside lipid nanometer milk content is 15 ~ 45%.
Further, described rhodioside lipid nanometer Ruzhong, by weight percentage, the content of rhodioside is 0.05 ~ 5%; Preferably, Determination of Salidroside is 0.1 ~ 2%.
In the specific embodiment of the present invention, the invention provides a kind of embodiment of the best, constituent and the percentage by weight of described rhodioside lipid nanoemulsion are as follows: rhodioside 1%, phosphatidase 1 .5%, caprylic/capric glyceride 15%, polyglycerol acrylate 0.5%, Tween 80 1%, Polyethylene Glycol caprylic/capric glyceride 1%, glycerol 73%, water 7%.
Further, described cosmetics are also containing brightening agent and sunscreen.
As preferably, described sunscreen content is 1 ~ 30%; More preferably, described sunscreen content is 3 ~ 20%.
Wherein, described sunscreen is selected from one or more in OctMet, octyl dimethyl p-aminobenzoic acid, OXYBENZONE, ethylhexyl salicylate, titanium dioxide, zinc oxide.
As preferably, described brightener levels is 0.01 ~ 5%; More preferably, described brightener levels is 0.1 ~ 2%.
Wherein, described brightening agent is selected from one or more in retinoic acid, arbutin, γ-cysteine, kojic acid, Radix Glycyrrhizae extract.
Further, described cosmetics are the photodamage resistant gel containing rhodioside, and by weight, it consists of:
| Title | Content (w/w, %) |
| Rhodioside lipid nanoemulsion | 15～45 |
| Acritamer 940 (2% solution) | 20～40 |
| Methyl parahydroxybenzoate | 0.1～1 |
| Retinoic acid | 0.1～0.5 |
| Propylene glycol | 2～4 |
| Mineral oil | 3～10 |
| Hexadecanol | 0.5～2 |
| Propyl p-hydroxybenzoate | 0.05～0.2 |
| OctMet | 3～7.5 |
| Stearic acid | 2～5 |
| Triethanolamine | 0.2～1 |
| Water | Mend to 100; |
As preferably, it consists of:
| Title | Content (w/w, %) |
| Rhodioside lipid nanoemulsion | 15 |
| Acritamer 940 (2% solution) | 40 |
| Methyl parahydroxybenzoate | 0.2 |
| Retinoic acid | 0.1 |
| Propylene glycol | 2 |
| Mineral oil | 5 |
| Hexadecanol | 1.5 |
| propyl p-hydroxybenzoate | 0.1 |
| octMet | 5 |
| stearic acid | 3 |
| triethanolamine | 1 |
| water | mend to 100. |
Further, described cosmetics are the photodamage resistant emulsion containing rhodioside, and by weight, it consists of:
| Title | Content (w/w, %) |
| Rhodioside lipid nanoemulsion | 15～45 |
| OctMet | 3～7.5 |
| Sorbitol | 5～10 |
| γ-cysteine | 0.1～1 |
| Kazon | 0.05～0.5 |
| PEG400 Cera Flava ester | 10～20 |
| Polyoxyethylene fatty glyceride ester | 3～7 |
| Almond oil | 3～7 |
| Oily Flos Inulae extract | 1～5 |
| Purified water | Mend to 100; |
As preferably, it consists of:
| Title | Content (w/w, %) |
| Rhodioside lipid nanoemulsion | 30 |
| OctMet | 4.5 |
| Sorbitol | 5 |
| γ-cysteine | 0.5 |
| Kazon | 0.1 |
| PEG400 Cera Flava ester | 10 |
| Polyoxyethylene fatty glyceride ester | 5 |
| almond oil | 5 |
| oily Flos Inulae extract | 2 |
| purified water | mend to 100. |
Further, described cosmetics are the photodamage resistant emulsion containing rhodioside, and by weight, it consists of:
| Title | Content (w/w, %) |
| Rhodioside lipid nanoemulsion | 15～45 |
| Acritamer 940 (2% solution) | 10～30 |
| Annular dimethyl polysiloxane | 1～3 |
| Arbutin | 0.1～2 |
| Stearic acid | 1～3 |
| Parleam | 3～7 |
| OctMet | 3～7.5 |
| Ethylhexyl salicylate | 2～5 |
| OXYBENZONE | 3～7 |
| Propyl p-hydroxybenzoate | 0.05～1 |
| Triethanolamine | 0.2～1 |
| Water | Mend to 100; |
As preferably, it consists of:
| Title | Content (w/w, %) |
| Rhodioside lipid nanoemulsion | 45 |
| Acritamer 940 (2% solution) | 15 |
| Annular dimethyl polysiloxane | 2 |
| Arbutin | 0.5 |
| Stearic acid | 1.5 |
| Parleam | 3 |
| OctMet | 7.5 |
| ethylhexyl salicylate | 5 |
| oXYBENZONE | 3 |
| propyl p-hydroxybenzoate | 0.15 |
| triethanolamine | 0.5 |
| water | mend to 100. |
Cosmetics of the present invention, wherein the consumption of water is as the criterion finally to make the total consumption of each component in cosmetic formulations reach 100%.
Beneficial effect of the present invention is:
Hydrophilic molecule, using lipid nanoemulsion as rhodioside carrier, is wrapped in the amphipathic systems such as Emulsion by the present invention, improves skin to the absorbance of rhodioside, significantly strengthens the bioavailability of hydrophilic molecules.By the ultraviolet protection (sunscreen) of abiotic activity and the bioactive ingredients (rhodioside) eliminating interior free yl; and brightening agent efficient combination; while protection skin avoids ultraviolet radiation, eliminate the damage that radical pair skin causes.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment 1 rhodioside lipid nanoemulsion
1, form
| Constituent | Weight ratio (%) |
| Rhodioside | 1 |
| Phospholipid | 1.5 |
| Caprylic/capric glyceride | 15 |
| Polyglycerol acrylate | 0.5 |
| Tween 80 | 1 |
| Polyethylene Glycol caprylic/capric glyceride | 1 |
| Glycerol | 73 |
| Water | 7 |
2, preparation method:
1) by recipe quantity, by phospholipid, caprylic/capric glyceride, polyglycerol acrylate, Tween 80, the mixing of Polyethylene Glycol caprylic/capric glyceride, high speed shear under 8000rpm condition, without the visible solid content of naked eyes to system;
2) rhodioside is added step 1) product, under 200rpm condition, the system that is stirred to is limpid transparent;
3) glycerol, water are added step 2) product, high speed shear under 10000rpm condition, after obtaining colostrum, high pressure homogenizer process, pressure 2000bar used, circulates 10 times, obtains rhodioside lipid nanoemulsion.
Embodiment 2 rhodioside lipid nanoemulsion
1, form
| Constituent | Weight ratio (%) |
| Rhodioside | 0.1 |
| Phospholipid | 1.5 |
| Caprylic/capric glyceride | 15 |
| Polyglycerol acrylate | 0.5 |
| Tween 80 | 1 |
| Polyethylene Glycol caprylic/capric glyceride | 1 |
| Glycerol | 73.9 |
| Water | 7 |
2, preparation method:
1) by recipe quantity, by phospholipid, caprylic/capric glyceride, polyglycerol acrylate, Tween 80, the mixing of Polyethylene Glycol caprylic/capric glyceride, high speed shear under 8000rpm condition, without the visible solid content of naked eyes to system;
2) rhodioside is added step 1) product, under 200rpm condition, the system that is stirred to is limpid transparent;
3) glycerol, water are added step 2) product, high speed shear under 10000rpm condition, after obtaining colostrum, high pressure homogenizer process, pressure 2000bar used, circulates 10 times, obtains rhodioside lipid nanoemulsion.
Embodiment 3 rhodioside lipid nanoemulsion
1, form
| Constituent | Weight ratio (%) |
| Rhodioside | 2 |
| Phospholipid | 1.5 |
| Caprylic/capric glyceride | 15 |
| Polyglycerol acrylate | 0.5 |
| Tween 80 | 1 |
| Polyethylene Glycol caprylic/capric glyceride | 1 |
| Glycerol | 72 |
| Water | 7 |
2, preparation method:
1) by recipe quantity, by phospholipid, caprylic/capric glyceride, polyglycerol acrylate, Tween 80, the mixing of Polyethylene Glycol caprylic/capric glyceride, high speed shear under 8000rpm condition, without the visible solid content of naked eyes to system;
2) rhodioside is added step 1) product, under 200rpm condition, the system that is stirred to is limpid transparent;
3) glycerol, water are added step 2) product, high speed shear under 10000rpm condition, after obtaining colostrum, high pressure homogenizer process, pressure 2000bar used, circulates 10 times, obtains rhodioside lipid nanoemulsion.
Embodiment 4 is containing the photodamage resistant gel of rhodioside
1, form
2, preparation method:
After B, component C are heated to 70 DEG C respectively, mixing, under 3000rpm stirring condition, adds D component, after stirring 15min, after system is down to room temperature, under 600rpm stirring condition, adds component A, continues to stir 3min, to obtain final product.
Embodiment 5 is containing the photodamage resistant emulsion of rhodioside
1, form
2, preparation method:
After B, component C are heated to 70 DEG C respectively, mixing, 3000rpm after system is down to room temperature, adds component A after stirring 15min under 600rpm stirring condition, continues to stir 3min, to obtain final product.
Embodiment 6 is containing the photodamage resistant emulsion of rhodioside
1, form
2, preparation method:
B, component C are heated to 75 DEG C respectively, and mixing, under 3000rpm stirring condition, adds D component, after stirring 15min, after system is down to room temperature, under 600rpm stirring condition, adds component A, continues to stir 3min, to obtain final product.
Experimental example 1 sun-proof result is tested
Test method: the pertinent regulations detected with reference to spf value in " gel hygienic practice " (version in 2002), slightly changes.30 healthy volunteers are chosen, each 15 of men and women in test, IV type skin (namely seldom tan severely, but easily tanned skin quality), unglazed allergies.30 volunteers are divided into 3 groups, often organize 10 people.
The product of sample 1-3 prepared by embodiment of the present invention 4-6;
Reference substance 11: the composition of reference example 4 and preparation method, unlike, will wherein rhodioside lipid nanoemulsion, change the aqueous solution done containing identical Determination of Salidroside, all the other components and preparation method constant.
Reference substance 12: the composition of reference example 4 and preparation method, unlike, by the embodiment 1 rhodioside lipid nanoemulsion wherein used, change other lipid nanoemulsions done containing identical Determination of Salidroside, be specially: relative to the rhodioside lipid nanoemulsion of embodiment 1, delete phospholipid, retain other components, the content of caprylic/capric glyceride is brought up to 16.5%, and preparation method is constant.
Reference substance 21: the composition of reference example 5 and preparation method, unlike, will wherein rhodioside lipid nanoemulsion, change the aqueous solution done containing identical Determination of Salidroside, all the other components and preparation method constant.
Reference substance 22: the composition of reference example 5 and preparation method, unlike, by the embodiment 1 rhodioside lipid nanoemulsion wherein used, change other lipid nanoemulsions done containing identical Determination of Salidroside, be specially: relative to the rhodioside lipid nanoemulsion of embodiment 1, Tween 80 is changed and makes polysorbas20, all the other components and preparation method constant.
Reference substance 31: the composition of reference example 6 and preparation method, unlike, will wherein rhodioside lipid nanoemulsion, change the aqueous solution done containing identical Determination of Salidroside, all the other components and preparation method constant.
Reference substance 32: the composition of reference example 6 and preparation method, unlike, by the embodiment 1 rhodioside lipid nanoemulsion wherein used, change other lipid nanoemulsions done containing identical Determination of Salidroside, be specially: relative to the rhodioside lipid nanoemulsion of embodiment 1, delete Polyethylene Glycol caprylic/capric glyceride, retain other components, the content of caprylic/capric glyceride is brought up to 16%, and preparation method is constant.
Experimental result is in table 1:
The different sample spf value of table 1
| Test group | SPF |
| Sample 1 | 15 |
| Reference substance 11 | 6.5 |
| Reference substance 12 | 12 |
| Sample 2 | 25 |
| Reference substance 21 | 10 |
| Reference substance 22 | 20 |
| Sample 3 | 30 |
| Reference substance 31 | 17 |
| Reference substance 32 | 25 |
Can be seen by table 1:
1, adopt lipid nanoemulsion as the sample of rhodioside carrier, compared with not using the reference substance of lipid nanoemulsion, spf value significantly improves, and sun-proof result is more excellent.Illustrate, adopt lipid nanoemulsion as carrier, significantly improve the absorbance of skin to rhodioside, enhance the bioavailability of hydrophilic molecules.
2, adopt embodiment 1 lipid nanoemulsion as the sample of rhodioside carrier, with adopt a little fine setting done to component lipid nanoemulsion as rhodioside carrier reference substance compared with, spf value has clear superiority equally, and sun-proof result is more excellent.Illustrate, the formula of lipid nanoemulsion of the present invention has made contribution equally to overall technical architecture, and this formula can improve the absorbance of skin to rhodioside better, strengthens the bioavailability of hydrophilic molecules.
Experimental example 2 melanin inhibition test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 6 orifice plates.Every hole 3ml, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandons supernatant, and PBS washs, and every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2ml maintenance medium and stops digestion.After piping and druming mixing, often kind of concentration is taken out 0.5mL and is made cell counting.All the other cell suspension, with the centrifugal 5min of 2500r/min, abandon supernatant, add sodium hydroxide solution, melanin is dissolved in precipitation, select 490nm wavelength to survey absorbance on enzyme-linked immunosorbent assay instrument, calculate melanin generating suppression, the results are shown in Table 2.
Trial target is with experimental example 1.
Melanin generating suppression=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance ÷ control wells cell density] × 100%
Table 2 melanin generating suppression
| Test group | Suppression ratio % |
| Sample 1 | 23.8 |
| Reference substance 11 | 8.5 |
| Reference substance 12 | 18.6 |
| Sample 2 | 27.4 |
| Reference substance 21 | 9.3 |
| Reference substance 22 | 20.9 |
| Sample 3 | 29.1 |
| Reference substance 31 | 10.2 |
| Reference substance 32 | 22.1 |
Can be seen by table 2:
1, adopt lipid nanoemulsion as the sample of rhodioside carrier, compared with not using the reference substance of lipid nanoemulsion, greatly strengthen melanin generating suppression.Illustrate, adopt lipid nanoemulsion as carrier, significantly improve the absorbance of skin to rhodioside and brightening agent, enhance the bioavailability of hydrophilic molecules.
2, adopt embodiment 1 lipid nanoemulsion as the sample of rhodioside carrier, with adopt a little fine setting done to component lipid nanoemulsion as rhodioside carrier reference substance compared with, cell viability has clear superiority equally.Illustrate, the formula of lipid nanoemulsion of the present invention has made contribution equally to overall technical architecture, and this formula can improve the absorbance of skin to rhodioside and brightening agent better, strengthens the bioavailability of hydrophilic molecules.
Experimental example 3 tryrosinase vitality test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 96 orifice plates.Every hole 100 μ L, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandon supernatant, PBS washing twice, and every hole adds the PBS of 90 μ L containing 1% (volume fraction) Triton X-100.Ultrasonication in ice bath, every hole adds the L-dopa of 10 μ L 10mmoL/L, hatches 60min for 37 DEG C, and in 475nm place colorimetric, blank well returns to zero, and surveys each hole absorbance, calculates inhibitory activity against tyrosinase, the results are shown in Table 3.
Trial target is with experimental example 1.
Suppression ratio=(1-medicine group mean absorbance values ÷ matched group mean absorbance values) × 100%.
Table 3 inhibitory activity against tyrosinase
| Test group | Inhibitory activity against tyrosinase % |
| Sample 1 | 29.5 |
| Reference substance 11 | 15.2 |
| Reference substance 12 | 19.2 |
| Sample 2 | 23.8 |
| Reference substance 21 | 11.2 |
| Reference substance 22 | 16.7 |
| Sample 3 | 27.1 |
| Reference substance 31 | 13.8 |
| Reference substance 32 | 17.1 |
Can be seen by table 3:
1, adopt lipid nanoemulsion as the sample of rhodioside carrier, compared with not using the reference substance of lipid nanoemulsion, to tyrosinase activity inhibitory action, be significantly improved.Illustrate, adopt lipid nanoemulsion as carrier, significantly improve the absorbance of skin to rhodioside and brightening agent, enhance the bioavailability of hydrophilic molecules.
2, adopt embodiment 1 lipid nanoemulsion as the sample of rhodioside carrier, with adopt a little fine setting done to component lipid nanoemulsion as rhodioside carrier reference substance compared with, inhibitory activity against tyrosinase has clear superiority equally.Illustrate, the formula of lipid nanoemulsion of the present invention has made contribution equally to overall technical architecture, and this formula can improve the absorbance of skin to rhodioside and brightening agent better, strengthens the bioavailability of hydrophilic molecules.
Experimental example 4MTT activity test
Take the logarithm the human epidermal cell HEK-n of trophophase, according to 1 × 10
5the concentration of cells/mL inoculates 96 orifice plates, every pore volume 200 μ L, after normal cultivation 24h, in protection group cell culture fluid, adds trial target respectively, after 5min, adopts 1mM H respectively
2o
2carry out oxidative damage process 6h.After oxidative damage process terminates, take out 96 well culture plates, abandon supernatant, after carefully rushing 2-3 time with PBS, then add the fresh medium of 200 μ L containing 0.5mg/mL MTT, continue at 37 DEG C, 5%CO
24h is cultivated under condition.After cultivation terminates, discard MTT solution, every hole adds 100 μ LDMSO, vibration mixing, surveys each hole absorbance (A490) that wavelength is 490nm, calculates cell survival rate, the results are shown in Table 4.
Trial target is with experimental example 1.
Table 4MTT activity test
| Test group | Cell survival rate % |
| Sample 1 | 60.3 |
| Reference substance 11 | 41.2 |
| Reference substance 12 | 56.8 |
| Sample 2 | 69.8 |
| Reference substance 21 | 41.9 |
| Reference substance 22 | 63.5 |
| Sample 3 | 71.7 |
| Reference substance 31 | 45.1 |
| Reference substance 32 | 65.1 |
Can be seen by table 4:
1, adopt lipid nanoemulsion as the sample of rhodioside carrier, compared with not using the reference substance of lipid nanoemulsion, greatly improve cell viability.Illustrate, adopt lipid nanoemulsion as carrier, significantly improve the absorbance of skin to rhodioside, enhance the bioavailability of hydrophilic molecules.
2, adopt embodiment 1 lipid nanoemulsion as the sample of rhodioside carrier, with adopt a little fine setting done to component lipid nanoemulsion as rhodioside carrier reference substance compared with, cell viability has clear superiority equally.Illustrate, the formula of lipid nanoemulsion of the present invention has made contribution equally to overall technical architecture, and this formula can improve the absorbance of skin to rhodioside better, strengthens the bioavailability of hydrophilic molecules.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1., containing photodamage resistant cosmetics for rhodioside, it is characterized in that, described cosmetics contain rhodioside lipid nanoemulsion, and by weight percentage, described rhodioside lipid nanometer milk content is 5 ~ 50%.
2. cosmetics according to claim 1, is characterized in that, described rhodioside lipid nanometer Ruzhong, and by weight percentage, the content of rhodioside is 0.05 ~ 5%.
3. cosmetics according to claim 1 and 2, it is characterized in that, constituent and the percentage by weight of described rhodioside lipid nanoemulsion are as follows: rhodioside 1%, phosphatidase 1 .5%, caprylic/capric glyceride 15%, polyglycerol acrylate 0.5%, Tween 80 1%, Polyethylene Glycol caprylic/capric glyceride 1%, glycerol 73%, water 7%.
4. cosmetics according to claim 3, is characterized in that, described cosmetics are also containing brightening agent and sunscreen; Described brightener levels is 0.01 ~ 5%.
5. cosmetics according to claim 4, is characterized in that, described brightening agent be selected from retinoic acid, arbutin, γ-cysteine, kojic acid, Radix Glycyrrhizae extract one or more.
6. cosmetics according to claim 3, is characterized in that, described sunscreen content is 3 ~ 20%.
7. cosmetics according to claim 6, is characterized in that, described sunscreen is selected from one or more in OctMet, octyl dimethyl p-aminobenzoic acid, OXYBENZONE, ethylhexyl salicylate, titanium dioxide, zinc oxide.
8. cosmetics according to claim 3, is characterized in that, described cosmetics are the photodamage resistant gel containing rhodioside, and by weight, it consists of:
As preferably, it consists of:
9. cosmetics according to claim 3, is characterized in that, described cosmetics are the photodamage resistant emulsion containing rhodioside, and by weight, it consists of:
As preferably, it consists of:
10. cosmetics according to claim 3, is characterized in that, described cosmetics are the photodamage resistant emulsion containing rhodioside, and by weight, it consists of:
As preferably, it consists of:
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Cited By (4)
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| CN110613640A (en) * | 2019-09-05 | 2019-12-27 | 西施兰（南阳）药业股份有限公司 | Herbal essence and preparation method thereof |
| CN112773860A (en) * | 2021-01-18 | 2021-05-11 | 澳邦制药(横琴)有限公司 | Wanying ointment and preparation method thereof |
| CN113499273A (en) * | 2021-07-30 | 2021-10-15 | 绍兴孚原生物科技有限公司 | Hair dye containing salidroside nanoparticles and preparation method and use method thereof |
| WO2023083226A1 (en) * | 2021-11-10 | 2023-05-19 | 山东恒鲁生物科技有限公司 | α-SALIDROSIDE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF |
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| CN113499273A (en) * | 2021-07-30 | 2021-10-15 | 绍兴孚原生物科技有限公司 | Hair dye containing salidroside nanoparticles and preparation method and use method thereof |
| WO2023083226A1 (en) * | 2021-11-10 | 2023-05-19 | 山东恒鲁生物科技有限公司 | α-SALIDROSIDE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF |
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