CN104585508A - Feed additive for preventing and treating swine red dysentery and preparation method thereof - Google Patents
Feed additive for preventing and treating swine red dysentery and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a feed additive for preventing and treating swine red dysentery and a preparation method thereof. The feed additive for preventing and treating swine red dysentery comprises a crushed chicory herb substance, a crushed soap bark substance, a crushed gentiana lutea substance, a crushed liquorice root substance and a crushed juniperus communis substance. Another feed additive for preventing and treating swine red dysentery comprises a chicory herb extract, a soap bark extract, a gentiana lutea extract, a liquorice root extract and a juniperus communis extract. The feed additives for preventing and treating pig coccidiosis disclosed by the invention have the effects of clearing heat and removing toxicity, and stopping bleeding by astringency, can be used for effectively reducing the morbidity of red dysentery, and have the effects of red dysentery prevention and animal health caring. In addition, the feed additives cannot cause medicine resistance, do not have medicine residues, and ensure that the requirements of people for food safety can be met; and moreover, the feed additives can be taken as veterinary medicines by improving dosages and changing dosage forms.
Description
Technical field
The present invention relates to a kind of feed addictive, particularly one control pig dysentery characterized by blood in the stool feed addictive and preparation method thereof.
Background technology
Pig dysentery characterized by blood in the stool is sick, sick also known as pig bloody flux, pig bloody flux is a kind of serious enteric infectious disease caused by the snakelike treponema of swine dysentery, Treponema Hyodysenteriae main harm 42-84 age in days, average weight is the pig of 30-35kg, during morbidity about average 90 ages in days, body weight easily infects in the pig of more than 20kg fattening period, and infection rate can reach 80%, what diarrhea wherein occurred about has 36%-67%, symptomless infection rate is 30%-50%, infects the duration to be generally 14d, the longlyest reaches 42d.Also have this cause of disease of report that the pig of about 75% can be caused to fall ill, the pig of 5%-25% is dead, and it is low that the external infection rate reported has height to have, and infection rate is between 49%-50%.When swinery breaks out this disease, mostly be the most acute and acute in initial 1-2 month, later gradually based on subacute and chronic, if introduce pig, general pig introduces rear 4-30d morbidity, has carried out huge economic loss to cultivation industrial belt.
Prevent about pig farm abuse of antibiotics at present, cause a large amount of antibiotic residues and serious drug resistance thereof, cause huge economic loss.The present invention is pure Chinese medicinal preparation, the advantage such as have high efficiency, security, no drug residue, have no drug resistance, and effectively can solve the problem of pig dysentery characterized by blood in the stool disease.
Summary of the invention
The object of this invention is to provide and a kind ofly prevent and treat feed addictive of pig dysentery characterized by blood in the stool and preparation method thereof, effectively preventing pig dysentery characterized by blood in the stool, solve antibiotic and remain in pig body in a large number and drug resistance problems, carried out guarantee to food safety belt.
To achieve these goals, the invention provides and a kind ofly prevent and treat feed addictive of pig dysentery characterized by blood in the stool and preparation method thereof, comprising:
The witloof crushed material of 1-10 part, the soapbark crushed material of 1-10 part, the gentian crushed material of 1-10 part, the licorice powder of 1-10 part mince, the Chinese juniper crushed material of 1-10 part.
The invention provides and a kind ofly prevent and treat feed addictive of pig dysentery characterized by blood in the stool and preparation method thereof, comprising:
The witloof crushed material of 2-8 part, the soapbark crushed material of 2-8 part, the gentian crushed material of 2-8 part, the licorice powder of 2-8 part mince, the Chinese juniper crushed material of 2-8 part.
The invention provides and a kind ofly prevent and treat feed addictive of pig dysentery characterized by blood in the stool and preparation method thereof, comprising:
The witloof crushed material of 5 parts, the soapbark crushed material of 5 parts, the gentian crushed material of 6 parts, the licorice powder of 5 parts mince, the Chinese juniper crushed material of 6 parts.
To achieve these goals, the invention provides a kind of preparation method preventing and treating the feed addictive of pig dysentery characterized by blood in the stool, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are dried 2-4h at temperature 50-60 DEG C;
(2) witloof after drying, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are crushed to 80-120 order fineness, obtain witloof crushed material respectively, soapbark crushed material, Huanglong's crushed material, licorice powder mince, Chinese juniper crushed material;
(3) the gentian crushed material of the soapbark crushed material of the witloof crushed material of 1-10 part, 1-10 part, 1-10 part, the licorice powder of 1-10 part are minced, the Chinese juniper crushed material of 1-10 part is mixed into crushed mixture, stir 10-15 minute.
To achieve these goals, present invention also offers a kind of feed addictive adopting described control pig dysentery characterized by blood in the stool: the constituent comprising following percentage by weight: the feed addictive 0.1-0.5% of described control pig dysentery characterized by blood in the stool and auxiliary material 99.5-99.9%.
To achieve these goals, present invention also offers a kind of control pig dysentery characterized by blood in the stool feed addictive, comprise the chicory extract of 1-10 part, the soapbark extract of 1-10 part, the gentian extract of 1-10 part, the licorice of 1-10 part, the Juniperus oxycedrus extract of 1-10 part.
To achieve these goals, present invention also offers a kind of control pig dysentery characterized by blood in the stool feed addictive, comprise the chicory extract of 2-8 part, the soapbark extract of 2-8 part, the gentian extract of 2-8 part, the licorice of 2-8 part, the Juniperus oxycedrus extract of 2-8 part.
To achieve these goals, present invention also offers a kind of control pig dysentery characterized by blood in the stool feed addictive, comprise the chicory extract of 5 parts, the soapbark extract of 6 parts, the gentian extract of 6 parts, the licorice of 5 parts, the Juniperus oxycedrus extract of 6 parts.
To achieve these goals, present invention also offers a kind of preparation method preventing and treating pig dysentery characterized by blood in the stool feed addictive, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are cut into the fragment of 1-2cm;
(2) witloof fragment 6-10 40-80% alcohol extract doubly, extracts 2 times, merges extract, pressure is concentrated under 0.05-0.08MPa, by dry at 50-60 DEG C of temperature for the extract after concentrated, then be crushed to 100-200 order fineness, obtain chicory extract.
(3) soapbark fragment and Radix Glycyrrhizae fragment 6-8 water doubly extract 1-3h at every turn, extract 2-4 time, merge extract, pressure is concentrated under 0.05-0.08MPa, by dry at 50-60 DEG C of temperature for the extract after concentrated, then be crushed to 100-200 order fineness, obtain soapbark extract.
(4) gentian fragment and Chinese juniper fragment 6-10 70-90% alcohol extract doubly, extract 2 times, merge extract, pressure is concentrated under 0.05-0.08MPa, by dry at 50-60 DEG C of temperature for the extract after concentrated, then be crushed to 100-200 order fineness, obtain chicory extract.
(5) licorice of the gentian extract of the soapbark extract of the chicory extract of 1-10 part, 1-10 part, 1-10 part, 1-10 part, the Juniperus oxycedrus extract of 1-10 part are mixed into crushed mixture, stir 10-15 minute.
To achieve these goals, present invention also offers a kind of feed addictive adopting described control pig dysentery characterized by blood in the stool: the constituent comprising following percentage by weight: the feed addictive 0.1-0.5% of described control pig dysentery characterized by blood in the stool and auxiliary material 99.5-99.9%.
The invention provides and a kind ofly prevent and treat feed addictive of pig dysentery characterized by blood in the stool and preparation method thereof, concrete following advantage:
1. the feed addictive that the present invention prevents and treats pig dysentery characterized by blood in the stool has the effect improving animal body immunity, can effectively reduce the incidence of pig dysentery characterized by blood in the stool, have the effect of good prevention and health care.
2. the present invention may be used for each stage of pig, and natural drug residue free of drawing materials, can not drug resistance be produced.
3. the present invention increasing dose and change formulation etc. can also be used as veterinary drug use.
4. preparation technology's science of the present invention, the simple requirement being applicable to industrialized production.
Detailed description of the invention
Below by embodiment, the present invention is elaborated, therefore do not limit the present invention among described scope of embodiments.
Embodiment 1
The preparation method of control pig dysentery characterized by blood in the stool feed addictive, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are dried 4h under temperature 50 C;
(2) witloof after drying, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are crushed to 80 order fineness, obtain witloof crushed material respectively, soapbark crushed material, Huanglong's crushed material, licorice powder mince, Chinese juniper crushed material;
(3) the witloof crushed material of 1 part, the soapbark crushed material of 1 part, the gentian crushed material of 1 part, the licorice powder of 1 part are minced, the Chinese juniper crushed material of 1 part is mixed into crushed mixture, stir 10 minutes.
(4) feed addictive 0.1% of the control pig dysentery characterized by blood in the stool described in and auxiliary material 99.9%.
Embodiment 2
The preparation method of control pig dysentery characterized by blood in the stool feed addictive, is characterized in that, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are cut into the fragment of 1cm;
(2) witloof fragment 40% alcohol extract of 6 times, extracts 2 times, merges extract, and pressure is concentrated under 0.05MPa, by dry at 50 DEG C of temperature for the extract after concentrated, then is crushed to 100 order fineness, obtains chicory extract.
(3) soapbark fragment and Radix Glycyrrhizae fragment extract 1h with the water of 6 times at every turn, and extract 2 times, merge extract, pressure is concentrated under 0.05MPa, by dry at 50 DEG C of temperature for the extract after concentrated, then is crushed to 100 order fineness, obtains soapbark extract.
(4) gentian fragment and Chinese juniper fragment 70% alcohol extract of 6 times, extract 2 times, merges extract, and pressure is concentrated under 0.05MPa, by dry at 50 DEG C of temperature for the extract after concentrated, then is crushed to 100 order fineness, obtains chicory extract.
(5) chicory extract of 5 parts, the soapbark extract of 6 parts, the gentian extract of 6 parts, the licorice of 5 parts, the Juniperus oxycedrus extract of 6 parts are mixed into crushed mixture, stir 10 minutes.
(6) feed addictive 0.1% of the control pig dysentery characterized by blood in the stool described in and auxiliary material 99.9%.
Embodiment 3
The preparation method of control pig dysentery characterized by blood in the stool feed addictive, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are dried 3h at temperature 55 DEG C;
(2) witloof after drying, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are crushed to 100 order fineness, obtain witloof crushed material respectively, soapbark crushed material, Huanglong's crushed material, licorice powder mince, Chinese juniper crushed material;
(3) the witloof crushed material of 5 parts, the soapbark crushed material of 5 parts, the gentian crushed material of 6 parts, the licorice powder of 5 parts are minced, the Chinese juniper crushed material of 6 parts is mixed into crushed mixture, stir 12 minutes.
(4) feed addictive 0.3% of the control pig dysentery characterized by blood in the stool described in and auxiliary material 99.7%.
Embodiment 4
The preparation method of control pig dysentery characterized by blood in the stool feed addictive, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are cut into the fragment of 1.5cm;
(2) witloof fragment 60% alcohol extract of 8 times, extracts 3 times, merges extract, and pressure is concentrated under 0.06MPa, by dry at 55 DEG C of temperature for the extract after concentrated, then is crushed to 150 order fineness, obtains chicory extract.
(3) soapbark fragment and Radix Glycyrrhizae fragment extract 2h with the water of 7 times at every turn, and extract 3 times, merge extract, pressure is concentrated under 0.06MPa, by dry at 55 DEG C of temperature for the extract after concentrated, then is crushed to 150 order fineness, obtains soapbark extract.
(4) gentian fragment and Chinese juniper fragment 80% alcohol extract of 8 times, extract 3 times, merges extract, and pressure is concentrated under 0.06MPa, by dry at 55 DEG C of temperature for the extract after concentrated, then is crushed to 150 order fineness, obtains chicory extract.
(5) chicory extract of 5 parts, the soapbark extract of 6 parts, the gentian extract of 6 parts, the licorice of 5 parts, the Juniperus oxycedrus extract of 6 parts are mixed into crushed mixture, stir 12 minutes.
(6) feed addictive 0.3% of the control pig dysentery characterized by blood in the stool described in and auxiliary material 99.7%.
Embodiment 5
The preparation method of control pig dysentery characterized by blood in the stool feed addictive, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are dried 2h under temperature 60 C;
(2) witloof after drying, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are crushed to 120 order fineness, obtain witloof crushed material respectively, soapbark crushed material, Huanglong's crushed material, licorice powder mince, Chinese juniper crushed material;
(3) the witloof crushed material of 10 parts, the soapbark crushed material of 10 parts, the gentian crushed material of 10 parts, the licorice powder of 10 parts are minced, the Chinese juniper crushed material of 10 parts is mixed into crushed mixture, stir 15 minutes.
(4) feed addictive 0.5% of the control pig dysentery characterized by blood in the stool described in and auxiliary material 99.5%.
Embodiment 6
The preparation method of control pig dysentery characterized by blood in the stool feed addictive, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are cut into the fragment of 2cm;
(2) witloof fragment 80% alcohol extract of 10 times, extracts 4 times, merges extract, and pressure is concentrated under 0.08MPa, by dry at 60 DEG C of temperature for the extract after concentrated, then is crushed to 200 order fineness, obtains chicory extract.
(3) soapbark fragment and Radix Glycyrrhizae fragment extract 3h with the water of 8 times at every turn, and extract 4 times, merge extract, pressure is concentrated under 0.08MPa, by dry at 60 DEG C of temperature for the extract after concentrated, then is crushed to 200 order fineness, obtains soapbark extract.
(4) gentian fragment and Chinese juniper fragment 90% alcohol extract of 10 times, extract 4 times, merges extract, and pressure is concentrated under 0.08MPa, by dry at 60 DEG C of temperature for the extract after concentrated, then is crushed to 200 order fineness, obtains chicory extract.
(5) chicory extract of 10 parts, the soapbark extract of 10 parts, the gentian extract of 10 parts, the licorice of 10 parts, the Juniperus oxycedrus extract of 10 parts are mixed into crushed mixture, stir 15 minutes.
(6) feed addictive 0.5% of the control pig dysentery characterized by blood in the stool described in and auxiliary material 99.5%.
Test example
1 test method
Select frequent certain pig farm Stochastic choice body weight that dysentery characterized by blood in the stool occurs to be the piglet 200 of about 12kg, be divided into 4 groups, feed containing the feed of embodiment 2, embodiment 4, embodiment 6 respectively for 1,2,3 group, 4 groups of chow diet of feeding.And it is uninterrupted to feed continuously.Observe the situation that dysentery characterized by blood in the stool occurs on pig farm, and not ill pig is weighed, statistics.
Criterion: sick just spirit is slightly poor, poor appetite, ight soil surface is with mucus, there is diarrhea afterwards, discharge loose stool that is yellow or grey, sick temperature of pig body is increased to more than 40, and spirit is depressed, lose weight, amount of drinking water increases, the ight soil and appearance redness or black are smelt as of rotten fish, in the pasty state, inside there are a large amount of mucus, clot or purulent secretion, some ight soil band pseudomembranes.Seriously ill pig hogback hangs abdomen, and dehydration is become thin, and walking is rocked, perianal and root of the tail faecal contamination, becomes thin and extremely weak, finally dead.Take ill pig fresh excreta or dead piglet colorectal mucosa smear, with the dyeing of Ji's Pehanorm, microscopy, finds 3-5 bar conveyor screw in the visual field.Get pathological material of disease to add physiological saline and make pressure and drip a sample simultaneously, observe under the dark field of 600 power microscopes, find that there is 2-3 in each visual field slowly in the comparatively king bolt body of snakelike sample motion.Pig dysentery characterized by blood in the stool is detected as positive through EUSA.
2 result of the tests
(1) there is the situation of dysentery characterized by blood in the stool
Through observing: the pig of 4 groups of chow diet of feeding has 15 to occur dysentery characterized by blood in the stool symptom, wherein has 4 to occur the phenomena of mortality, microscopy finds there is conveyor screw in the visual field, and it is positive that EUSA is detected as pig dysentery characterized by blood in the stool; 1 group has 8 to suffer from dysentery characterized by blood in the stool disease wherein to have 2 to occur the phenomena of mortality; 2 groups have 1 to occur slight dysentery characterized by blood in the stool disease symptoms, do not have pig dead; 3 groups have 2 to occur dysentery characterized by blood in the stool symptom, do not have pig dead.Feed continuously 15 days, concrete condition is as following table:
There is dysentery characterized by blood in the stool situation in table 1
Group | Sum (head) | Ill number (head) | Death toll (head) | Illness rate (%) | The death rate (%) |
1 group | 50 | 8 | 2 | 16 | 4 |
2 groups | 50 | 1 | 0 | 2 | 0 |
3 groups | 50 | 2 | 0 | 4 | 0 |
4 groups | 50 | 15 | 4 | 30 | 8 |
From result: compared with blank group, 1 group (embodiment 2), 2 groups (embodiment 4), 3 groups (embodiments 6) effectively can both prevent the generation of dysentery characterized by blood in the stool, reduce M & M, and the effect of 2 groups (embodiments 4) is the most obvious.
(2) pig Gain weight
Get not ill piglet 30, weigh one by one, calculate the Gain weight of piglet.As following table:
Table 2 weight gain of piglets situation
Group | Sum (head) | First body weight (kg) | Opisthosoma heavy (kg) | Weightening finish (kg) |
1 group | 30 | 12 | 25.9 | 13.9 |
2 groups | 30 | 12 | 28.5 | 16.5 |
3 groups | 30 | 12 | 26.3 | 14.3 |
4 groups | 30 | 12 | 24.6 | 12.6 |
From result: compared with blank group, 1 group (embodiment 2), 2 groups (embodiment 4), 3 groups (embodiments 6) effectively can both increase the body weight of piglet, and the effect of 2 groups (embodiments 4) is the most obvious.
Claims (10)
1. prevent and treat a pig dysentery characterized by blood in the stool feed addictive, it is characterized in that, comprise the witloof crushed material of 1-10 part, the soapbark crushed material of 1-10 part, the gentian crushed material of 1-10 part, the licorice powder of 1-10 part mince, the Chinese juniper crushed material of 1-10 part.
2. one control pig dysentery characterized by blood in the stool feed addictive according to claim 2, it is characterized in that, comprise the witloof crushed material of 2-8 part, the soapbark crushed material of 2-8 part, the gentian crushed material of 2-8 part, the licorice powder of 2-8 part mince, the Chinese juniper crushed material of 2-8 part.
3. one control pig dysentery characterized by blood in the stool feed addictive according to claim 3, is characterized in that, comprises the witloof crushed material of 5 parts, the soapbark crushed material of 5 parts, the gentian crushed material of 6 parts, the licorice powder of 5 parts mince, the Chinese juniper crushed material of 6 parts.
4. the preparation method of control pig dysentery characterized by blood in the stool feed addictive according to claim 1, is characterized in that, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are dried 2-4h at temperature 50-60 DEG C;
(2) witloof after drying, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are crushed to 80-120 order fineness, obtain witloof crushed material respectively, soapbark crushed material, Huanglong's crushed material, licorice powder mince, Chinese juniper crushed material;
(3) the gentian crushed material of the soapbark crushed material of the witloof crushed material of 1-10 part, 1-10 part, 1-10 part, the licorice powder of 1-10 part are minced, the Chinese juniper crushed material of 1-10 part is mixed into crushed mixture, stir 10-15 minute.
5., according to one control pig dysentery characterized by blood in the stool feed addictive prepared by claim 4, it is characterized in that, comprise the constituent of following percentage by weight: the feed addictive 0.1-0.5% of described control pig dysentery characterized by blood in the stool and auxiliary material 99.5-99.9%.
6. prevent and treat a pig dysentery characterized by blood in the stool feed addictive, it is characterized in that, comprise the chicory extract of 1-10 part, the soapbark extract of 1-10 part, the gentian extract of 1-10 part, the licorice of 1-10 part, the Juniperus oxycedrus extract of 1-10 part.
7. one control pig dysentery characterized by blood in the stool feed addictive according to claim 6, it is characterized in that, comprise the chicory extract of 2-8 part, the soapbark extract of 2-8 part, the gentian extract of 2-8 part, the licorice of 2-8 part, the Juniperus oxycedrus extract of 2-8 part.
8. one control pig dysentery characterized by blood in the stool feed addictive according to claim 7, is characterized in that, comprise the chicory extract of 5 parts, the soapbark extract of 6 parts, the gentian extract of 6 parts, the licorice of 5 parts, the Juniperus oxycedrus extract of 6 parts.
9. prevent and treat a preparation method for pig dysentery characterized by blood in the stool feed addictive, it is characterized in that, comprising:
(1) respectively the witloof after cleaning, soapbark, gentian, Radix Glycyrrhizae, Chinese juniper are cut into the fragment of 1-2cm;
(2) witloof fragment 6-10 40-80% alcohol extract doubly, extracts 2-4 time, merges extract, pressure is concentrated under 0.05-0.08MPa, by dry at 50-60 DEG C of temperature for the extract after concentrated, then be crushed to 100-200 order fineness, obtain chicory extract.
(3) soapbark fragment and Radix Glycyrrhizae fragment 6-8 water doubly extract 1-3h at every turn, extract 2 times, merge extract, pressure is concentrated under 0.05-0.08MPa, by dry at 50-60 DEG C of temperature for the extract after concentrated, then be crushed to 100-200 order fineness, obtain soapbark extract.
(4) gentian fragment and Chinese juniper fragment 6-10 70-90% alcohol extract doubly, extract 2 times, merge extract, pressure is concentrated under 0.05-0.08MPa, by dry at 50-60 DEG C of temperature for the extract after concentrated, then be crushed to 100-200 order fineness, obtain chicory extract.
(5) licorice of the gentian extract of the soapbark extract of the chicory extract of 1-10 part, 1-10 part, 1-10 part, 1-10 part, the Juniperus oxycedrus extract of 1-10 part are mixed into crushed mixture, stir 10-15 minute.
10., according to one control pig dysentery characterized by blood in the stool feed addictive prepared by claim 9, it is characterized in that, comprise the constituent of following percentage by weight: the feed addictive 0.1-0.5% of described control pig dysentery characterized by blood in the stool and auxiliary material 99.5-99.9%.
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CN1102342A (en) * | 1994-04-29 | 1995-05-10 | 柳铁宏 | Radix sophorae flavescentis, large-flowered skullcap root and coptis root tablet |
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2015
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EP0029665A1 (en) * | 1979-11-10 | 1981-06-03 | Beecham Group Plc | Antibacterial derivatives of monic acid, processes for their preparation and compositions containing them |
CN1102342A (en) * | 1994-04-29 | 1995-05-10 | 柳铁宏 | Radix sophorae flavescentis, large-flowered skullcap root and coptis root tablet |
CN104161181A (en) * | 2013-07-18 | 2014-11-26 | 河南联合英伟饲料有限公司 | Feed additive for preventing pig bacterial diseases, preparation method and application thereof |
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