CN104583236A - 高度多样的组合抗体文库 - Google Patents

高度多样的组合抗体文库 Download PDF

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Publication number
CN104583236A
CN104583236A CN201380044638.9A CN201380044638A CN104583236A CN 104583236 A CN104583236 A CN 104583236A CN 201380044638 A CN201380044638 A CN 201380044638A CN 104583236 A CN104583236 A CN 104583236A
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China
Prior art keywords
antibody
library
human
families
antibodies
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Pending
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CN201380044638.9A
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English (en)
Chinese (zh)
Inventor
约翰内斯·约斯夫·威廉默斯·德哈德
克里斯托夫·弗雷德里克·杰罗姆·布朗什托
亚历克斯·克拉伦比克
伊克贝尔·阿舒尔
哈利尔·埃尔马祖阿里
于尔根·德尔法韦罗
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ArgenX SE
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ArgenX SE
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Publication of CN104583236A publication Critical patent/CN104583236A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
CN201380044638.9A 2012-08-31 2013-09-02 高度多样的组合抗体文库 Pending CN104583236A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261695819P 2012-08-31 2012-08-31
US61/695,819 2012-08-31
PCT/EP2013/068110 WO2014033304A2 (en) 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries

Publications (1)

Publication Number Publication Date
CN104583236A true CN104583236A (zh) 2015-04-29

Family

ID=49117845

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380044638.9A Pending CN104583236A (zh) 2012-08-31 2013-09-02 高度多样的组合抗体文库

Country Status (9)

Country Link
US (1) US10040870B2 (https=)
EP (1) EP2890709A2 (https=)
JP (1) JP6283030B2 (https=)
CN (1) CN104583236A (https=)
AU (1) AU2013310839B2 (https=)
CA (1) CA2879834A1 (https=)
IL (1) IL236524B (https=)
IN (1) IN2015DN00138A (https=)
WO (1) WO2014033304A2 (https=)

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CN110139952A (zh) * 2016-12-09 2019-08-16 深圳华大生命科学研究院 骆驼科抗体可变区免疫组库构建的引物组合及应用

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EA201792573A1 (ru) 2015-05-21 2018-04-30 Харпун Терапьютикс, Инк. Триспецифические связанные белки и способы их применения
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
JP7101621B2 (ja) 2016-05-20 2022-07-15 ハープーン セラピューティクス，インク． 単一ドメイン血清アルブミン結合タンパク質
CN116987189A (zh) 2016-05-20 2023-11-03 哈普恩治疗公司 单链可变片段cd3结合蛋白质
AU2017292184A1 (en) 2016-07-08 2019-02-07 Staten Biotechnology B.V. Anti-Apoc3 antibodies and methods of use thereof
EP3544629A4 (en) * 2016-11-23 2020-06-17 Harpoon Therapeutics, Inc. PSMA TO BE TRISPECIFIC PROTEINS AND METHOD FOR USE THEREOF
CN110198955A (zh) 2016-11-23 2019-09-03 哈普恩治疗公司 前列腺特异性膜抗原结合蛋白质
EP3589662A4 (en) 2017-02-28 2020-12-30 Harpoon Therapeutics, Inc. INDUCTIBLE MONOVALENT ANTIGEN BINDING PROTEIN
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
WO2018209304A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
AU2018265856B2 (en) 2017-05-12 2023-04-27 Harpoon Therapeutics, Inc. Mesothelin binding proteins
HRP20241268T1 (hr) 2017-10-13 2024-12-06 Harpoon Therapeutics, Inc. Trispecifični proteini i postupci primjene
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
KR20200074975A (ko) 2017-10-31 2020-06-25 스태튼 바이오테크놀로지 비.브이. 항-ApoC3 항체 및 이의 사용 방법
KR20210020903A (ko) 2018-05-14 2021-02-24 하푼 테라퓨틱스, 인크. 면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티
WO2020061482A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Egfr binding proteins and methods of use
SG11202103022WA (en) 2018-09-25 2021-04-29 Harpoon Therapeutics Inc Dll3 binding proteins and methods of use
US12516128B2 (en) 2019-05-14 2026-01-06 Harpoon Therapeutics, Inc. EpCAM binding proteins and methods of use
CA3170833A1 (en) 2020-02-21 2021-08-26 Harpoon Therapeutics, Inc. Flt3 binding proteins and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216328A (zh) * 2008-07-02 2011-10-12 阿尔金-X公司 骆驼科动物来源的抗原结合多肽

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
US8444976B2 (en) 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
CA2762837C (en) * 2009-05-20 2021-08-03 Novimmune S.A. Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants
GB2476681B (en) 2010-01-04 2012-04-04 Argen X Bv Humanized camelid VH, VK and VL immunoglobulin domains

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216328A (zh) * 2008-07-02 2011-10-12 阿尔金-X公司 骆驼科动物来源的抗原结合多肽

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DARREN J SCHOFIELD等: "Application of phage display to high throughput antibody generation and characterization", 《GENOME BIOLOGY》 *
HANS J. DE HAARD等: "A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110139952A (zh) * 2016-12-09 2019-08-16 深圳华大生命科学研究院 骆驼科抗体可变区免疫组库构建的引物组合及应用
CN110139952B (zh) * 2016-12-09 2022-11-25 深圳华大生命科学研究院 骆驼科抗体可变区免疫组库构建的引物组合及应用

Also Published As

Publication number Publication date
AU2013310839B2 (en) 2017-06-01
WO2014033304A3 (en) 2014-05-01
JP2015526495A (ja) 2015-09-10
JP6283030B2 (ja) 2018-02-21
US10040870B2 (en) 2018-08-07
AU2013310839A1 (en) 2015-01-29
CA2879834A1 (en) 2014-03-06
US20150166680A1 (en) 2015-06-18
IN2015DN00138A (https=) 2015-06-12
IL236524B (en) 2019-01-31
IL236524A0 (en) 2015-02-26
WO2014033304A2 (en) 2014-03-06
EP2890709A2 (en) 2015-07-08

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