CA2879834A1 - Highly diverse combinatorial antibody libraries - Google Patents

Highly diverse combinatorial antibody libraries Download PDF

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Publication number
CA2879834A1
CA2879834A1 CA2879834A CA2879834A CA2879834A1 CA 2879834 A1 CA2879834 A1 CA 2879834A1 CA 2879834 A CA2879834 A CA 2879834A CA 2879834 A CA2879834 A CA 2879834A CA 2879834 A1 CA2879834 A1 CA 2879834A1
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CA
Canada
Prior art keywords
antibody
library
human
families
lambda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2879834A
Other languages
English (en)
French (fr)
Inventor
Johannes Joseph Wilhelmus De Haard
Christophe Frederic Jerome Blanchetot
Alex KLARENBEEK
Ikbel ACHOUR
Khalil EL MAZOUARI
Jurgen DEL FAVERO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ArgenX BVBA
Original Assignee
ArgenX SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ArgenX SE filed Critical ArgenX SE
Publication of CA2879834A1 publication Critical patent/CA2879834A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
CA2879834A 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries Abandoned CA2879834A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261695819P 2012-08-31 2012-08-31
US61/695,819 2012-08-31
PCT/EP2013/068110 WO2014033304A2 (en) 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries

Publications (1)

Publication Number Publication Date
CA2879834A1 true CA2879834A1 (en) 2014-03-06

Family

ID=49117845

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2879834A Abandoned CA2879834A1 (en) 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries

Country Status (9)

Country Link
US (1) US10040870B2 (https=)
EP (1) EP2890709A2 (https=)
JP (1) JP6283030B2 (https=)
CN (1) CN104583236A (https=)
AU (1) AU2013310839B2 (https=)
CA (1) CA2879834A1 (https=)
IL (1) IL236524B (https=)
IN (1) IN2015DN00138A (https=)
WO (1) WO2014033304A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201792573A1 (ru) 2015-05-21 2018-04-30 Харпун Терапьютикс, Инк. Триспецифические связанные белки и способы их применения
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
JP7101621B2 (ja) 2016-05-20 2022-07-15 ハープーン セラピューティクス，インク． 単一ドメイン血清アルブミン結合タンパク質
CN116987189A (zh) 2016-05-20 2023-11-03 哈普恩治疗公司 单链可变片段cd3结合蛋白质
AU2017292184A1 (en) 2016-07-08 2019-02-07 Staten Biotechnology B.V. Anti-Apoc3 antibodies and methods of use thereof
EP3544629A4 (en) * 2016-11-23 2020-06-17 Harpoon Therapeutics, Inc. PSMA TO BE TRISPECIFIC PROTEINS AND METHOD FOR USE THEREOF
CN110198955A (zh) 2016-11-23 2019-09-03 哈普恩治疗公司 前列腺特异性膜抗原结合蛋白质
WO2018103093A1 (zh) * 2016-12-09 2018-06-14 深圳华大基因研究院 骆驼科抗体可变区免疫组库构建的引物组合及应用
EP3589662A4 (en) 2017-02-28 2020-12-30 Harpoon Therapeutics, Inc. INDUCTIBLE MONOVALENT ANTIGEN BINDING PROTEIN
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
WO2018209304A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
AU2018265856B2 (en) 2017-05-12 2023-04-27 Harpoon Therapeutics, Inc. Mesothelin binding proteins
HRP20241268T1 (hr) 2017-10-13 2024-12-06 Harpoon Therapeutics, Inc. Trispecifični proteini i postupci primjene
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
KR20200074975A (ko) 2017-10-31 2020-06-25 스태튼 바이오테크놀로지 비.브이. 항-ApoC3 항체 및 이의 사용 방법
KR20210020903A (ko) 2018-05-14 2021-02-24 하푼 테라퓨틱스, 인크. 면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티
WO2020061482A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Egfr binding proteins and methods of use
SG11202103022WA (en) 2018-09-25 2021-04-29 Harpoon Therapeutics Inc Dll3 binding proteins and methods of use
US12516128B2 (en) 2019-05-14 2026-01-06 Harpoon Therapeutics, Inc. EpCAM binding proteins and methods of use
CA3170833A1 (en) 2020-02-21 2021-08-26 Harpoon Therapeutics, Inc. Flt3 binding proteins and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
US8444976B2 (en) 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
GB2461546B (en) * 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
CA2762837C (en) * 2009-05-20 2021-08-03 Novimmune S.A. Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants
GB2476681B (en) 2010-01-04 2012-04-04 Argen X Bv Humanized camelid VH, VK and VL immunoglobulin domains

Also Published As

Publication number Publication date
AU2013310839B2 (en) 2017-06-01
WO2014033304A3 (en) 2014-05-01
JP2015526495A (ja) 2015-09-10
JP6283030B2 (ja) 2018-02-21
US10040870B2 (en) 2018-08-07
AU2013310839A1 (en) 2015-01-29
US20150166680A1 (en) 2015-06-18
IN2015DN00138A (https=) 2015-06-12
IL236524B (en) 2019-01-31
IL236524A0 (en) 2015-02-26
CN104583236A (zh) 2015-04-29
WO2014033304A2 (en) 2014-03-06
EP2890709A2 (en) 2015-07-08

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180816

FZDE Discontinued

Effective date: 20200831