CN104582770B - 在感染的治疗和预防中的神经酰胺水平 - Google Patents

在感染的治疗和预防中的神经酰胺水平 Download PDF

Info

Publication number
CN104582770B
CN104582770B CN201380031825.3A CN201380031825A CN104582770B CN 104582770 B CN104582770 B CN 104582770B CN 201380031825 A CN201380031825 A CN 201380031825A CN 104582770 B CN104582770 B CN 104582770B
Authority
CN
China
Prior art keywords
subject
ceramide
infection
ceramidase
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380031825.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN104582770A (zh
Inventor
爱德华·H·舒克曼
埃里希·古尔宾斯
安东尼·福特曼
耶·佩兹妮-琼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xi Naishanyikan Medical College
Yeda Research and Development Co Ltd
Original Assignee
Universitaet Duisburg Essen
Yeda Research and Development Co Ltd
Icahn School of Medicine at Mount Sinai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Duisburg Essen, Yeda Research and Development Co Ltd, Icahn School of Medicine at Mount Sinai filed Critical Universitaet Duisburg Essen
Priority to CN201811635845.2A priority Critical patent/CN109529028A/zh
Publication of CN104582770A publication Critical patent/CN104582770A/zh
Application granted granted Critical
Publication of CN104582770B publication Critical patent/CN104582770B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01023—Ceramidase (3.5.1.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380031825.3A 2012-06-01 2013-05-31 在感染的治疗和预防中的神经酰胺水平 Active CN104582770B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811635845.2A CN109529028A (zh) 2012-06-01 2013-05-31 在感染的治疗和预防中的神经酰胺水平

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654519P 2012-06-01 2012-06-01
US61/654,519 2012-06-01
PCT/US2013/043608 WO2013181530A1 (en) 2012-06-01 2013-05-31 Ceramide levels in the treatment and prevention of infections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811635845.2A Division CN109529028A (zh) 2012-06-01 2013-05-31 在感染的治疗和预防中的神经酰胺水平

Publications (2)

Publication Number Publication Date
CN104582770A CN104582770A (zh) 2015-04-29
CN104582770B true CN104582770B (zh) 2019-01-29

Family

ID=49673925

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380031825.3A Active CN104582770B (zh) 2012-06-01 2013-05-31 在感染的治疗和预防中的神经酰胺水平
CN201811635845.2A Pending CN109529028A (zh) 2012-06-01 2013-05-31 在感染的治疗和预防中的神经酰胺水平

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811635845.2A Pending CN109529028A (zh) 2012-06-01 2013-05-31 在感染的治疗和预防中的神经酰胺水平

Country Status (14)

Country Link
US (5) US9492514B2 (https=)
EP (2) EP3679923B1 (https=)
JP (5) JP6369814B2 (https=)
CN (2) CN104582770B (https=)
CA (1) CA2874146C (https=)
DK (1) DK2854910T3 (https=)
ES (2) ES2786128T3 (https=)
HR (1) HRP20200661T1 (https=)
HU (1) HUE051020T2 (https=)
LT (1) LT2854910T (https=)
PL (1) PL2854910T3 (https=)
PT (1) PT2854910T (https=)
SI (1) SI2854910T1 (https=)
WO (1) WO2013181530A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889127B2 (en) 2004-07-01 2014-11-18 Icahn School Of Medicine At Mount Sinai Targeted protein replacement for the treatment of lysosomal storage disorders
EP3219705B1 (en) 2005-12-28 2020-03-11 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US10350277B2 (en) 2011-09-07 2019-07-16 Icahn School Of Medicine At Mount Sinai Ceramidase and cell differentiation
PL2854910T3 (pl) * 2012-06-01 2020-07-27 Icahn School Of Medicine At Mount Sinai Poziomy ceramidu w leczeniu i zapobieganiu infekcjom
EP2971127B1 (en) 2013-03-14 2018-02-28 University Of Ottawa Methods for the diagnosis and treatment of inflammatory bowel disease
CA2905449C (en) 2013-03-14 2024-09-10 Icahn School Of Medicine At Mount Sinai THERAPEUTIC COMPOSITIONS OF ACID CERAMIDASE AND THEIR PROCESSES OF MANUFACTURE AND USE
CA2962802A1 (en) 2014-10-03 2016-04-07 University Of Ottawa Markers for inflammatory bowel disease
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
MX2019008038A (es) * 2017-01-13 2020-02-05 Icahn School Med Mount Sinai Composiciones y metodos para tratar la enfermedad de farber.
WO2022190064A1 (en) * 2021-03-12 2022-09-15 Vexo Pharmaceuticals Dmcc Methods for identifying subjects with betacoronavirus infections who are at risk of acute respiratory syndrome and methods for the treatment of same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1688316A (zh) * 2002-08-23 2005-10-26 埃里希·古尔宾斯 传染病的预防和治疗
US20080199450A1 (en) * 2007-01-05 2008-08-21 Mount Sinai School Of Medicine Acid ceramidase and cell survival
CN101479288A (zh) * 2006-04-24 2009-07-08 大学医疗中心 囊性纤维化的改进的治疗
US20100285139A1 (en) * 2007-12-21 2010-11-11 Cycnad Gmbh & Co., Kg Pharmaceutical composition for the prophylaxis and/or symptomatic treatment of cystic fibrosis
CN102368905A (zh) * 2008-11-06 2012-03-07 南卡罗来纳医科大学研究发展基金会 酸性神经酰胺酶的向溶酶体抑制剂

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
CH585793A5 (https=) 1974-02-01 1977-03-15 Nestle Sa
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
JPS5322158B2 (https=) 1974-05-02 1978-07-06
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
IT1130242B (it) 1980-02-01 1986-06-11 Anic Spa Procedimento per la produzione dell'enzima alfa-galattosidasi e per l'idrolisi del raffinosio mediante l'impiego dell'enzima stesso
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5059421A (en) 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0463109A4 (en) 1989-03-24 1992-11-19 Research Corporation Technologies, Inc. Recombinant alpha-galactosidase, a therapy for fabry disease
US5401650A (en) 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
US5382524A (en) 1990-10-24 1995-01-17 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-n-acetylgalactosaminidase
US5773278A (en) 1991-05-03 1998-06-30 Mount Sinai Medical Center Acid sphingomyelinase gene
US5433946A (en) 1991-10-11 1995-07-18 Health Research Inc. Synthesis and utilization of therapeutic agents for the treatment of lysosomal storage diseases
US5631237A (en) 1992-12-22 1997-05-20 Dzau; Victor J. Method for producing in vivo delivery of therapeutic agents via liposomes
CA2149444A1 (en) 1992-12-30 1994-07-21 George Joe Revis Anticaries compositions
WO1995001164A1 (en) 1993-06-30 1995-01-12 Genentech, Inc. Method for preparing liposomes
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5997861A (en) 1994-10-31 1999-12-07 Burstein Laboratories, Inc. Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin
US5817789A (en) 1995-06-06 1998-10-06 Transkaryotic Therapies, Inc. Chimeric proteins for use in transport of a selected substance into cells
US5643599A (en) 1995-06-07 1997-07-01 President And Fellows Of Harvard College Intracellular delivery of macromolecules
US6118045A (en) 1995-08-02 2000-09-12 Pharming B.V. Lysosomal proteins produced in the milk of transgenic animals
US6884435B1 (en) 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
IL135578A0 (en) 1997-10-29 2001-05-20 Genzyme Corp Compositions and methods for treating lysosomal storage disease
AU753303B2 (en) 1998-03-10 2002-10-17 Trustees Of The University Of Pennsylvania, The Enhancement of intracellular delivery and tissue targeting of drugs and genes
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
US7018628B1 (en) 1998-07-24 2006-03-28 Aventis Pharma S.A. Vectors derived from baculovirus and use for transferring nucleic acids into nerve cells of vertebrates
US6258581B1 (en) 1998-08-20 2001-07-10 Takara Shuzo Co., Ltd. Ceramidase gene
GB9909064D0 (en) 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
US6730297B1 (en) 1999-05-28 2004-05-04 Chiron Corporation Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders
US7927587B2 (en) 1999-08-05 2011-04-19 Regents Of The University Of Minnesota MAPC administration for the treatment of lysosomal storage disorders
US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
US6537785B1 (en) 1999-09-14 2003-03-25 Genzyme Glycobiology Research Institute, Inc. Methods of treating lysosomal storage diseases
WO2001026678A1 (en) 1999-10-13 2001-04-19 Yeda Research And Development Co. Ltd. Short segments of dap-kinase
US6350768B1 (en) 1999-11-24 2002-02-26 Aventis Pharma S.A. Combination of riluzole and of gabapentin and its use as a medicament
US7850984B2 (en) 2000-02-15 2010-12-14 The General Hospital Corporation Protection of the female reproductive system from natural and artificial insults
IL152110A0 (en) 2000-04-06 2003-07-31 Exegenics Inc Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase)
US20040204379A1 (en) 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
CA2432978C (en) 2000-12-22 2012-08-28 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
US20020142299A1 (en) 2001-01-09 2002-10-03 Davidson Beverly L. PTD-modified proteins
EP1234816B1 (de) 2001-02-23 2004-06-30 Biofrontera Pharmaceuticals GmbH Scyphostatin-Analoga als SMase-Inhibitoren
ATE384736T1 (de) 2001-04-30 2008-02-15 Zystor Therapeutics Inc Subzelluläres targeting von therapeutischen proteinen
US7232670B2 (en) 2001-09-28 2007-06-19 St. Jude Children's Research Hospital Targeting proteins to cells expressing mannose receptors via expression in insect cells
CA2473360A1 (en) 2002-01-25 2003-08-07 Genzyme Corporation Serum-free media for chondrocytes and methods of use thereof
AU2003224880A1 (en) 2002-04-05 2003-10-27 Genzyme Corporation Methods of enhancing lysosomal storage disease therapy
EP1431399A1 (en) 2002-12-20 2004-06-23 Clinigenetics Methods and composition for identifying therapeutic agents of atherosclerotic plaque lesions
ATE521701T1 (de) 2003-01-22 2011-09-15 Univ Duke Verbesserte konstrukte zur expression lysosomaler polypeptide
US20050026823A1 (en) 2003-06-20 2005-02-03 Biomarin Pharmaceutical Inc. Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
NZ588323A (en) 2003-07-17 2012-04-27 Pacific Edge Biotechnology Ltd Markers for the detection of gastric cancer
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US8889127B2 (en) 2004-07-01 2014-11-18 Icahn School Of Medicine At Mount Sinai Targeted protein replacement for the treatment of lysosomal storage disorders
US7273756B2 (en) 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US8017394B2 (en) 2004-10-01 2011-09-13 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
WO2006050265A2 (en) 2004-10-29 2006-05-11 Musc Foundation For Research Development Ceramides and apoptosis-signaling ligand
US7993868B2 (en) 2005-04-19 2011-08-09 Vermillion, Inc. Saposin D and FAM3C are biomarkers for alzheimer's disease
CN101282733A (zh) * 2005-08-03 2008-10-08 莫里亚生物制药公司 脂质结合物在囊性纤维化病中的用途及其应用
US7981399B2 (en) 2006-01-09 2011-07-19 Mcgill University Method to determine state of a cell exchanging metabolites with a fluid medium by analyzing the metabolites in the fluid medium
WO2007089734A2 (en) 2006-01-27 2007-08-09 Eastern Virginia Medical School Proteomic fingerprinting of human ivf-derived embryos: identification of biomarkers of developmental potential
WO2007095688A1 (en) 2006-02-23 2007-08-30 The Australian National University Methods for increasing the number of circulating cells
WO2007136635A1 (en) 2006-05-16 2007-11-29 Musc Foundation For Research Development Enhancement of radiation therapy and/or chemotherapy with acid ceramidase modulators
EP2302395B1 (en) 2006-06-07 2015-04-15 Health Diagnostic Laboratory, Inc. Markers associated with arteriovascular events and methods of use thereof
AU2007261530B2 (en) 2006-06-20 2014-02-06 Genzyme Corporation Serum-free media and their uses for chondrocyte expansion
KR20090127153A (ko) 2007-04-06 2009-12-09 겐자임 코포레이션 세포 및 세포 배양물의 평가 방법
EP3486653A1 (en) 2007-05-24 2019-05-22 The United States Government as represented by The Department of Veterans Affairs Treatment of skeletal muscle disorder using ent2
AU2008255565B2 (en) 2007-05-31 2013-10-24 Paradigm Biopharmaceuticals Ltd Sulphated xylans for treatment or prophylaxis of respiratory diseases
FR2924946B1 (fr) 2007-12-18 2010-02-26 Oreal Utilisation cosmetique de proteines de type ceramidase acide
AU2009262670B2 (en) 2008-06-26 2013-06-20 Zevra Denmark A/S Use of Hsp70 as a regulator of enzymatic activity
US20100068302A1 (en) * 2008-09-17 2010-03-18 Traslational Cancer Drugs Pharma, S.L. Methods and compositions for the treatment of cancer
WO2010127355A1 (en) 2009-05-01 2010-11-04 Mount Sinai School Of Medicine Method to determine embryo and oocyte quality based on ceramidase
SI3998078T1 (sl) 2009-08-28 2026-02-27 Genzyme Corporation Encimsko nadomestno zdravljenje z naraščajočim odmerkom za zdravljenje pomanjkanja kisle sfingomielinaze
WO2011049737A1 (en) 2009-10-19 2011-04-28 Amicus Therapeutics, Inc. Novel compositions for preventing and/or treating lysosomal storage disorders
WO2011066352A1 (en) 2009-11-27 2011-06-03 Genzyme Corporation An amorphous and a crystalline form of genz 112638 hemitartrat as inhibitor of glucosylceramide synthase
WO2012051415A2 (en) 2010-10-13 2012-04-19 Mount Sinai School Of Medicine Inhibitors of acid ceramidase and uses thereof in cancer and other disease treatment therapies
WO2013101276A2 (en) 2011-04-01 2013-07-04 Mount Sinai School Of Medicine Diagnosis and detection of disease conditions modulated by activation of the sphingolipid pathway
US9140635B2 (en) 2011-05-10 2015-09-22 Advanced Liquid Logic, Inc. Assay for measuring enzymatic modification of a substrate by a glycoprotein having enzymatic activity
WO2012177778A1 (en) 2011-06-20 2012-12-27 Mount Sinai School Of Medicine Anti-tnf- therapy for the mucopolysaccharidoses and other lysosomal disorders
US10350277B2 (en) 2011-09-07 2019-07-16 Icahn School Of Medicine At Mount Sinai Ceramidase and cell differentiation
PL2854910T3 (pl) * 2012-06-01 2020-07-27 Icahn School Of Medicine At Mount Sinai Poziomy ceramidu w leczeniu i zapobieganiu infekcjom
CA2905449C (en) 2013-03-14 2024-09-10 Icahn School Of Medicine At Mount Sinai THERAPEUTIC COMPOSITIONS OF ACID CERAMIDASE AND THEIR PROCESSES OF MANUFACTURE AND USE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1688316A (zh) * 2002-08-23 2005-10-26 埃里希·古尔宾斯 传染病的预防和治疗
CN101479288A (zh) * 2006-04-24 2009-07-08 大学医疗中心 囊性纤维化的改进的治疗
US20080199450A1 (en) * 2007-01-05 2008-08-21 Mount Sinai School Of Medicine Acid ceramidase and cell survival
US20100285139A1 (en) * 2007-12-21 2010-11-11 Cycnad Gmbh & Co., Kg Pharmaceutical composition for the prophylaxis and/or symptomatic treatment of cystic fibrosis
CN102368905A (zh) * 2008-11-06 2012-03-07 南卡罗来纳医科大学研究发展基金会 酸性神经酰胺酶的向溶酶体抑制剂

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis;Katrin Anne Becker等;《AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY》;20100601;第42卷(第6期);第716页-第724页 *

Also Published As

Publication number Publication date
EP3679923B1 (en) 2021-08-04
US20150125439A1 (en) 2015-05-07
EP2854910A4 (en) 2016-02-24
HRP20200661T1 (hr) 2020-10-30
US9492514B2 (en) 2016-11-15
JP2023021305A (ja) 2023-02-10
JP2015518054A (ja) 2015-06-25
DK2854910T3 (da) 2020-05-04
ES2897825T3 (es) 2022-03-02
PT2854910T (pt) 2020-05-06
SI2854910T1 (sl) 2020-09-30
CA2874146C (en) 2023-03-21
JP6369814B2 (ja) 2018-08-08
JP2025102904A (ja) 2025-07-08
EP2854910B1 (en) 2020-04-15
CA2874146A1 (en) 2013-12-05
HUE051020T2 (hu) 2021-01-28
CN104582770A (zh) 2015-04-29
LT2854910T (lt) 2020-05-25
JP2020050668A (ja) 2020-04-02
EP3679923A1 (en) 2020-07-15
US20170020998A1 (en) 2017-01-26
JP6639574B2 (ja) 2020-02-05
US20190151424A1 (en) 2019-05-23
EP2854910A1 (en) 2015-04-08
US20250186565A1 (en) 2025-06-12
WO2013181530A1 (en) 2013-12-05
US20220202919A1 (en) 2022-06-30
ES2786128T3 (es) 2020-10-08
JP2018162303A (ja) 2018-10-18
PL2854910T3 (pl) 2020-07-27
CN109529028A (zh) 2019-03-29
US10159724B2 (en) 2018-12-25

Similar Documents

Publication Publication Date Title
CN104582770B (zh) 在感染的治疗和预防中的神经酰胺水平
Martinez et al. Type 1 pilus‐mediated bacterial invasion of bladder epithelial cells
Merz et al. Attachment of piliated, Opa-and Opc-gonococci and meningococci to epithelial cells elicits cortical actin rearrangements and clustering of tyrosine-phosphorylated proteins
BR112020019484A2 (pt) Constructos polipeptídicos de lisina-peptídeo antimicrobiano (amp), lisinas, polinucleotídeos isolados codificando as mesmas e seus usos
Coureuil et al. Molecular interactions between Neisseria meningitidis and its human host
BR112020018787A2 (pt) Constructos de polipeptídeo de lisina-peptídeo antimicrobiano (amp), lisinas, polinucleotídeos isolados que codificam os mesmos e usos dos mesmos
Casalino-Matsuda et al. Hypercapnia suppresses macrophage antiviral activity and increases mortality of influenza A infection via Akt1
US20200157160A1 (en) Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof
CN109475515A (zh) 抗菌组合物
JP2026027378A (ja) 感染症における血行動態を変更する為の方法及び手段
BR112020019010A2 (pt) Polipeptídeos antimicrobianos derivados de bacteriófagos e seu uso contra bactérias gram-negativas
US20190345262A1 (en) Targeted anticoagulant
HK40006306A (en) Ceramide levels in the treatment and prevention of infections
HK40032815B (en) Ceramide levels in the treatment and prevention of infections
HK40032815A (en) Ceramide levels in the treatment and prevention of infections
WO2025222025A1 (en) Anti-fungal methods and anti-fungal compounds derived from chromobacterium vaccinii
Carey et al. Taste receptor T1R3 in nasal cilia detects Staphylococcus aureus D-amino acids to increase apical glucose uptake and enhance innate immunity
De Luna Peptides Against Influenza: Evaluating the Anti-Viral Characteristics of Regenerating Islet Derived Protein 3 and the Cathelicidin Ll-37
Moayeri et al. Bacillus anthracis Edema Toxin Inhibits Hypoxic Pulmonary Vasoconstriction 1 via Edema Factor and cAMP Mediated Mechanisms in Isolated Perfused Rat Lungs 2 3 Xizhong Cui1, Jeffrey Wang1, Yan Li1, Zoe G. Couse1, Thomas F. Risoleo1, 4 Mahtab Moayeri2, Stephen H. Leppla2, Daniela Malide3, Zu-Xi Yu3, and Peter Q. Eichacker1 5
Ang et al. Analysis of the Infectious Entry Pathway of Dengue Viruses into Host Cells

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20180829

Address after: American New York

Applicant after: Xi Naishanyikan medical college

Applicant after: Yeda Research and Development Co., Ltd.

Address before: American New York

Applicant before: Xi Naishanyikan medical college

Applicant before: Yeda Research and Development Co., Ltd.

Applicant before: Univ Duisburg Essen

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant