CN104547089B - It is a kind of to treat medicine of rheumatism and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine for treating rheumatism and preparation method thereof, include the bulk drug of following weight parts：6 10 parts of tripterygium wilfordii, 48 parts of notopterygium root, 48 parts of levisticum, 0.1 10 parts of the root of Chinese clematis, 48 parts of reticulate millettia, 48 parts of dandelion, 48 parts of the root of fangji, 6 10 parts of radix cyathulae.By tripterygium wilfordii, notopterygium root, levisticum, the root of Chinese clematis, reticulate millettia, dandelion, the root of fangji, radix cyathulae by aforementioned weight match through over cleaning, drying, crushing, extracted with ethanol after mix and produce with turpentine oil.It is a kind of good effect, the medicine of the treatment rheumatism of Small side effects.Clinical 234 use, total effective rate 94.8%, obvious effective rate 90.6%, and medication is convenient and swift.

Description

It is a kind of to treat medicine of rheumatism and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, and in particular to a kind of medicine for treating rheumatism, also relate to the preparation of the medicine Method.

Background technology

Rheumatism is one group of infringement joint, bone, muscle, blood vessel and about the disease based on soft tissue or connective tissue, its It is middle most for autoimmune disease.Morbidity is much more hidden and slow, and the course of disease is longer, and has genetic predisposition mostly.Diagnosis and Treatment acquires a certain degree of difficulty；It is many in blood to check different autoantibodies, may be relevant from different HLA hypotypes；To non-steroid AID (NSAID), glucocorticoid and immunodepressant have preferably short-term or long-term palliative reaction.

The pathogenic factor of rheumatism includes immune response, heredity, infection, endocrine factor, environment and physical factor etc..Mesh Before, the treatment method for rheumatism mainly includes drug therapy and operative treatment.

The medicine for the treatment of rheumatic disease can be divided into following several classes：

1st, nonsteroidal anti-inflammatory agent (NSAIDs)：The effect of such medicine, predominantly antipyretic, anti-inflammatory and analgesia, and reach and subtract Subinflammation is reacted and purpose；

2nd, cortex hormone of aadrenaline：Glucocorticoid is primarily referred to as, because this kind of medicine has anti-inflammatory and immunosuppressive action, Have relatively strong and quickly diminish inflammation and various symptoms that inflammatory reaction is brought, such as generate heat, arthroncus and pain；

3rd, improve the state of an illness antirheumatic (DMARDs) it is also known as slow effect antirheumatic：Such medicine includes many Species structure is different, acts on different medicine.Their general character is that action is slow, there is certain cumulative effect, therefore after being discontinued, is made It is also relatively slow with disappearing, it can still maintain a period of time.They have no direct anti-inflammatory analgetic effect, but can be risen by different mechanism To anti-inflammatory and immune or immunosuppressive action.

4th, other medicines treatment includes GTW, Pa Fulin, Yun Ke etc..

Above medicine all has certain curative effect, but with cost it is high, easily recurrence, side effect is big the problems such as.And perform the operation The method for the treatment of can make rheumatisant bear bigger body and psychological pain again.

In bulk drug used in the present invention, tripterygium wilfordii（Tripterygium wilfordii）For Celastraceae plant Thunder God The xylem of rattan.Dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain, swelling and pain relieving, removing toxic substances desinsection.For damp and hot tubercle, carcinoma product poison, clinically use It treats lepra reaction, rheumatoid arthritis etc..

Notopterygium root（Notopterygium incisum）Samphire notopterygium root or the rhizome and root of notopterygium forbesii.Inducing diaphoresis dissipates It is cold, expelling wind and eliminating dampness, analgesic.For impotence and seminal emission, enuresis frequent micturition, waist and knee crymodynia, deficiency of the kidney and dyspnea, Diarrhoea；Leucoderma is controlled in external application Wind, alopecia areata.

Levisticum（Root of Doubleteeth Pubescent Angelica）For samphire Angelica pubescens Dry root.Cure mainly wind-cold-dampness arthralgia, soreness of waist and knee joint, trick contraction pain, chronic bronchitis, headache, dentalgia.

The root of Chinese clematis is the ranunculaceae plant root of Chinese clematis（Clematis chinensis Osbeck）, Clematis hexapetala （Clematis hexapetala Pall）Or northeast clematis（Clematis manshurica Rupr）Dry root and root Stem.There is dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain.For arthralgia pain due to rheumatism, extremity numbness, muscle arteries and veins contraction, joint stuffiness, bone is choked with sobs The diseases such as larynx.

Reticulate millettia legume spatholobus suberectus（Spatholobus suberectus）Rattan.Promoting blood circulation, relaxing muscles and tendons.Cure mainly waist and knee Ache, paralysis and numbness, irregular menstruation.

Dandelion is feverfew dandelion（Taraxacum officnala）Whole herb with root.Clearing heat and detoxicating, diuresis dissipates Knot.Acute mastitis is cured mainly, adenolymphitis, scrofula, malignant boil carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis is anxious Property bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infections.

The root of fangji is menispermaceous plants Fourstamen Stephania Root（Stephania tetrandra S.Moore）Dry root.Water-filling, rush down under It is burnt damp and hot.Cure mainly oedema tympanites, hygropyretic beriberi, brothers' contraction pain, tinea scabies sore swells.

Radix cyathulae is amaranthaceous plant radix cyathulae（Radix cyathulae）Dry root.Wind-dispelling, dampness removing, stimulate the menstrual flow, invigorate blood circulation. Cure mainly rheumatism lumbocrural pain, pin impotence muscle contraction, blood strangury, hematuria, women's Amenorrhea , Disorder lumps in the abdomen.For Amenorrhea abdominal mass, placenta retension, joint Numbness pain, sufficient impotence muscle contraction, cards such as hematuria blood drenches, injury from falling down.

Turpentine oil is the oleoresin oozed out in some plants of Pinaceae Pinus, the volatile oil obtained through distillation or extraction.Promoting blood circulation Dredging collateral, swelling and pain relieving.Cure mainly painful swelling of joints, courbature, traumatic injury.

The content of the invention

It is an object of the invention to provide a kind of good effect, the medicine of the treatment rheumatism of Small side effects.

Another object of the present invention is to the preparation method for the medicine for providing the treatment rheumatism.

The medicine of the present invention is prepared by the bulk drug of following weight proportion：

6-10 parts of tripterygium wilfordii, 4-8 parts of notopterygium root, 4-8 parts of levisticum, 0.1-10 parts of the root of Chinese clematis, 4-8 parts of reticulate millettia, dandelion 4-8 Part, 4-8 parts of the root of fangji, 6-10 parts of radix cyathulae.

Lotion can be made in the medicine of the present invention.

A kind of preparation method of medicine for treating rheumatism of the present invention, comprises the following steps：

（1）Bulk drug is screened, is sampled by weight ratio, is cleaned, dries, crushes；

（2）70% ethanol of 3.5-4.5 times of bulk drug weight is added, keeps 50 DEG C of -55 DEG C of temperature to be percolated after soaking 24 hours and carries Take, percolate reclaims ethanol；

（3）Alcohol content is adjusted to 30%, is filtered, filtrate addition turpentine oil 5ml-100ml is well mixed to be produced.

The present invention compared with prior art, with obvious beneficial effect, as can be known from the above technical solutions：The present invention is selected Tripterygium wilfordii, notopterygium root, levisticum, the root of Chinese clematis, reticulate millettia, dandelion, the root of fangji, radix cyathulae, turpentine oil are raw material, pass through the association of each medicine Same-action comes wind-damp dispelling, promoting blood circulation, analgesic, detumescence, prevents osseous lesion, its expense is low, good effect, Small side effects, and medication is convenient Fast.Clinical 234 use, total effective rate 94.8%, obvious effective rate 90.6%.

Embodiment

The beneficial effect of medicine of the present invention is expanded on further below by way of test example.

Test example：The clinical observation of medicine of the present invention

Clinical data：

All cases 234, wherein male 106, women 128, max age 76 years old are minimum 24 years old.

Diagnostic criteria：

《Disease of tcm Standardization of diagnosis and curative effect》

Treatment method：Patient body is made even position of lying, every time with decoction and water in proportion 1:4 heating immersions, are heated up to 80 DEG C It is down to 42 DEG C of holding 50nin, once a day, a course for the treatment of on the 5th, 1-2 course for the treatment of of the lighter, 4-5 course for the treatment of of severe one again afterwards.

External application lavipeditum.

Criterion of therapeutical effect：

It is effective：Symptom disappears

Effectively：Symptom is relieved

It is invalid：Symptom is without improvement or aggravates.

Treatment results：

234 patients are through drug therapy of the present invention, effective 212, effective 10, invalid 12, total effective rate 94.8%.

Embodiment 1

A kind of medicine for treating rheumatism, comprises the following steps：

（1）Weigh tripterygium wilfordii 0.6kg, notopterygium root 0.8kg, levisticum 0.4kg, root of Chinese clematis 0.8kg, reticulate millettia 0.8kg, dandelion 0.4kg, root of fangji 0.8kg, radix cyathulae 0.6kg, cleaning, drying, crushing；

（2）70% ethanol of 4 times of bulk drug weight is added, keeps 50 DEG C of temperature to be percolated after soaking 24 hours and extracts, percolate is reclaimed Ethanol；

（3）Alcohol content is adjusted to 30%, is filtered, filtrate addition turpentine oil 5ml is well mixed to be produced.

Embodiment 2

A kind of medicine for treating rheumatism, comprises the following steps：

（1）Weigh tripterygium wilfordii 1kg, notopterygium root 0.4kg, levisticum 0.8kg, root of Chinese clematis 0.4kg, reticulate millettia 0.4kg, dandelion 0.8kg, root of fangji 0.4kg, radix cyathulae 1kg, cleaning, drying, crushing；

（2）70% ethanol of 3.5 times of bulk drug weight is added, keeps 55 DEG C of temperature to be percolated after soaking 24 hours and extracts, percolate is returned Receive ethanol；

（3）Alcohol content is adjusted to 30%, is filtered, filtrate addition turpentine oil 100ml is well mixed to be produced.

Embodiment 3

A kind of medicine for treating rheumatism, comprises the following steps：

（1）Weigh tripterygium wilfordii 0.8kg, notopterygium root 0.6kg, levisticum 0.6kg, root of Chinese clematis 0.6kg, reticulate millettia 0.6kg, dandelion 0.6kg, root of fangji 0.6kg, radix cyathulae 0.8kg, cleaning, drying, crushing；

（2）70% ethanol of 5.5 times of bulk drug weight is added, keeps 52.5 DEG C of temperature to be percolated after soaking 24 hours and extracts, percolate Reclaim ethanol；

（3）Alcohol content is adjusted to 30%, is filtered, filtrate addition turpentine oil 75ml is well mixed to be produced.

Claims (3)

1. a kind of medicine for treating rheumatism, is made by the bulk drug of following weight parts：6-10 parts of tripterygium wilfordii, 4-8 parts of notopterygium root, levisticum 4-8 parts, 0.1-10 parts of the root of Chinese clematis, 4-8 parts of reticulate millettia, 4-8 parts of dandelion, 4-8 parts of the root of fangji, 6-10 parts of radix cyathulae.

2. the medicine of rheumatism is treated as claimed in claim 1, it is characterised in that：Described medicine is lotion.

3. the preparation method of the medicine for the treatment of rheumatism, comprises the following steps as claimed in claim 1：

（1）Bulk drug is screened, is sampled by weight ratio, is cleaned, dries, crushes；

（2）70% ethanol of 3.5-4.5 times of bulk drug weight is added, keeps 50 DEG C of -55 DEG C of temperature to be percolated after soaking 24 hours and extracts, ooze Filtrate recycling ethanol；

（3）Alcohol content is adjusted to 30%, is filtered, filtrate addition turpentine oil 5ml-100ml is well mixed to be produced.