CN104546983B - A kind of primary and secondary emplastrum for treating rheumatism and preparation method - Google Patents
A kind of primary and secondary emplastrum for treating rheumatism and preparation method Download PDFInfo
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Abstract
The present invention relates to field of medicaments, in particular to a kind of primary and secondary emplastrum for treating rheumatism and preparation method.Allow Weizhong point position and blood microcirculation that Shen Shu point allows, neutralizing disease pain gets through double cave smelting rheumatism, and including the big emplastrum being used cooperatively and sub- emplastrum, the big emplastrum and sub- emplastrum are by breathing freely patch and the ointment that is attached in the ventilative patch is formed；Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10 18 parts of frankincense, 10 20 parts of myrrh, 8 15 parts of Rhizoma Chuanxiong, 10 20 parts of safflower, 7 13 parts of centipede, 8 15 parts of scorpio；Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：8 12 parts of Caulis Spatholobi, 5 13 parts of rhizoma zingiberis, 6 12 parts of borneol.
Description
Technical field
The present invention relates to field of medicaments, in particular to a kind of primary and secondary emplastrum for treating rheumatism and preparation method.
Background technology
Rheumatism is one group of infringement joint, bone, muscle, blood vessel and in relation to the disease based on soft tissue or connective tissue,
Wherein most is autoimmune disease.Morbidity is much more hidden and slow, and the course of disease is longer, and has genetic predisposition mostly.Diagnosis
And treatment acquires a certain degree of difficulty；It is more in blood to check different autoantibodies, it may be related from different HLA hypotypes；To non-
Steroidal anti-inflammatory drugs (NSAID), glucocorticoid and immunosuppressor have preferable short-term or long-term palliative reaction.
Broadly think every and cause Bones and joints, the disease of myalgia can all be attributed to rheumatism.Continuity is got off, so far
In rheumatism classification, broad sense has more than 100 kinds of disease, includes infectivity, immunity, metabolic, incretion, heredity
Disease caused by many reasons such as property, degeneration, tumprigenicity, region, Poisoning.Internal medicine should be only limitted in the narrow sense with being immunized
Tens kinds of diseases of related scope.Some of which is sick or interdisciplinary, such as gout, osteoarthrosis, infectional arthritis etc..
Pathogenic factor has following several：
1. immune response：The stimulation that body exogenous or endogenous antigen substance are presented directly or by macrophage,
Make corresponding T- cell activations, some T-cell generates a large amount of a variety of inflammation cytokines and causes various organization organ different degrees of
Damage or destruction；Some T-cell reactivation B- cells generate lot of antibodies, are formed directly or with antigen binding immune compound
Object makes tissue or organ be damaged or destroy.In addition the monocyte chemoattractant protein (such as MCP-1) generated by monocyte
Deng may also participate in inflammatory reaction.Most of rheumatic disease or due to infection generate exogenous antigen substance or due to body
The endogenous antigen substance of interior generation can start or aggravate this autoimmune response, Multiple Antibodies are may occur in which in serum.
2. genetic background：Research in recent years has shown that some rheumatic diseases, particularly connective tissue disease, heredity and patient
Neurological susceptibility and disease expression it is closely related, early stage to disease or be not true to type case and prognosis has certain meaning；Its
Middle HLA (human tissue leukocyte antigen) is mostly important.
3. infective agent：It is illustrated according to research for many years, the multi-infection factor, the antigen or super anti-that microorganism generates
Original can be excited directly or indirectly or start immune response.4. endocrine factor：Research has shown that, the mistake of estrogen and progestational hormone
It adjusts, is related with the generation of a variety of rheumatism.5. environment and physical factor：As ultraviolet light can induce SLE.6. other：Some medicines
Product such as procainamide, some oral contraceptives can induce SLE and ANCA positive polyangitises.
Clinical manifestation
1. rheumatism has arthropathy and symptom mostly, up to 70-80%, about 50% only has pain, heavy then red, swells,
Heat, comprehensive inflammation performances such as bitterly and function is damaged；Mostly multi-joint is involved.Invade and disease is neglected in joint greatly and it is different.It is 2. different
Matter, i.e., same disease, there are different subtypes, and due to genetic background, pathogenic factor is different, and mechanism is also different, thus clinical
The type of performance, symptom, weight and therapeutic response are also not quite similar.3. rheumatism is mostly the disease for invading multisystem, many diseases
The pathology of disease has overlapping more, and symptom is similar, such as the typical case that MCTD is this performance.4. occur Multiple Antibodies in serum and be immunized multiple
Object (CIC) is closed, and can be deposited in tissue (skin, synovial membrane) or organ (kidney, liver) and cause a disease.5. Raynaud's phenomenon often comes across this class
Disease, such as SLE, MCTD.
Treatment
Rheumatic disease is a kind of autoimmune disease for invading Various Tissues multisystem and internal organs.Degree is different
Immune inflammation reaction, various tissues and organ damage can be caused into, seriously affect its normal function.Even mortality is caused to damage
Evil.In addition, most of rheumatic diseases have joint symptoms；Each patient, same disease, the different courses of disease have that its is special
Property.It should carefully evaluate, to work up the treatment plan of its people.Therapeutic purpose should include relief of symptoms, improve the state of an illness, recover
Function is improved the quality of living, as far as possible the life of continued patient.Since most of rheumatic disease can't effect a radical cure at present, because
This will strive for the cooperation of patient, adhere to treating for a long time.The method for the treatment of includes drug, physical therapy, rest and exercise, orthopedic and hand
Art.It educates patient and understands the state of an illness of oneself, partner treatment.
The drug of the treatment rheumatic disease used at present can be divided into following several classes：
1. nonsteroidal anti-inflammatory agent (NSAIDs)：The effect of such drug, predominantly antipyretic, anti-inflammatory and analgesia, and reach and subtract
Subinflammation is reacted and purpose.It is that aspirin (acetylsalicylic acid) is still treatment acute rheumatic fever and rheumatism joint so far earliest
Scorching active drug.Various Salicylates were produced later, it is common to have brufen, Diclofenac, Indomethacin, pyrrole sieve
Former times health, naproxen etc., but the pharmacokinetics of various drugs and adverse reaction are different, mainly to stomach and intestine, kidney, liver and blood
System is certain it is noted that dosage, usage, side effect etc. during use.
2. cortex hormone of aadrenaline：Glucocorticoid is primarily referred to as, because this kind of drug has anti-inflammatory and immunosuppressive action,
Have relatively strong and quickly diminish inflammation and various symptoms that inflammatory reaction is brought, such as generate heat, arthroncus and pain.So to each
Kind rheumatic disease, is often used as First Line drug.Having for clinically applying is short-acting, and middle effect waits preparations with long-acting.Usage has mouth
Clothes, muscle or intraarticular injection, intravenous injection, can be according to disease, and the state of an illness makees different selections.But since it is not radically curative drug
Object, long-term a large amount of use can induce infection, osteoporosis, caput femoris necrosis, diabetes, peptic ulcer, and hypertension is spiritual different
Often etc.；And be such as discontinued it is too fast be also easy to produce state of an illness rebound phenomenon, therefore should be noted that according to disease and the state of an illness, adjust the species using drug
And dosage.In addition to patient with severe symptoms, in principle with low dose, Low doses are advisable.
3. the also known as slow effect antirheumatic of the antirheumatic (DMARDs) for improving the state of an illness.Such drug includes many
Species structure is different, acts on different drug.Their general character is that action is slow, there is certain cumulative effect, therefore after being discontinued, make
It is also relatively slow with disappearing, it can still maintain a period of time.They have no direct anti-inflammatory analgetic effect, but can be risen by different mechanism
To anti-inflammatory and immune or immunosuppressive action.Thus, arthroncus can also be improved, pain, stiff and mitigation systemic conditions,
Reduce acute phase reactive protein, erythrocyte sedimentation rate.If usage time is longer, it can also improve other immune indexes, such as RF, ANA etc..Some is still
Irradiation image can be improved.The drug of DMARDs classes includes antimalarial-chloroquine, hydroxychloroquine, salicylazosulfapyridine, first ammonia
Pterin, imuran, cyclophosphamide, penicillamine, gold preparation, ciclosporin A and leflunomide.
Any of the above drug internal organs important to human body (liver, kidney, bladder, lung, stomach and intestine, gonad) and tissue (marrow) are each
There is different toxic side effects, and patient can not often differentiate well when selecting, and also it is expensive, it can be to patient
Medical treatment bring larger financial burden.
Meanwhile also have the rheumatism patch of substantial amounts of Chinese medicine class currently on the market, such as rheumatism rheumatalgia-relieving plaster etc, but it is big
Majority is simply temporary to relieve pain, it is impossible to fundamentally treat and cure rheumatism and rheumatoid arthritis, particularly with length
The patient of phase illness is not smelting sheet of taking stopgap measures, and in view of this, spy proposes the present invention.
The content of the invention
The first object of the present invention is to provide a kind of primary and secondary emplastrum for treating rheumatism, allows Weizhong point position and Shen Shu point allows
Blood microcirculation, neutralizing disease pain, gets through double cave smelting rheumatism.
The second object of the present invention is to provide a kind of preparation method for the primary and secondary emplastrum for treating rheumatism, in this method closely
Coordinate the characteristic of various drug ingedients, processed according to suitable method, the utilization of bulk pharmaceutical chemicals can be greatly improved by this method
Rate keeps the activity of raw material pharmaceutically active ingredient.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of primary and secondary emplastrum for treating rheumatism, including the big emplastrum being used cooperatively and sub- emplastrum, the big emplastrum and son paste
Cream is made of ventilative patch and the ointment being attached in the ventilative patch；
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10-18 parts of frankincense, myrrh 10-20
Part, 8-15 parts of Rhizoma Chuanxiong, 10-20 parts of safflower, 7-13 parts of centipede, 8-15 parts of scorpio；
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：8-12 parts of Caulis Spatholobi, rhizoma zingiberis 5-13
Part, 6-12 parts of borneol.
A kind of primary and secondary emplastrum for treating rheumatism provided by the invention, wherein the plaster on big emplastrum is by frankincense, myrrh, river
Rhizome of chuanxiong, safflower, centipede, full worm, scorpio are made, and wherein frankincense, pungent, bitter, temperature, primary efficacy be used for promoting blood circulation and stopping pain, muscle arteries and veins contraction,
Traumatic injury, sore, carbuncle and painful swelling, detumescence and promoting granulation；Myrrh, primary efficacy are to dissipate blood and dissolving stasis, detumescence ding-tong, ulcer sore pain；Rhizoma Chuanxiong, it is pungent
It is warm fragrant dry, it walks without keeping, can go scattered, uplink is pushed up up to mountain peak, and enters blood system, and for downlink up to the sea of blood, promoting blood circulation effect is extensive,
Suitable for the various illnesss of stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness are favourable.Safflower, invigorate blood circulation, removing blood stasis and analgesics, have it is promoting blood circulation and removing blood stasis, dissipate it is wet
Go the effect of swollen；The effect of centipede has wind-dispelling, and poison is attacked in arresting convulsion, dissipating bind；Scorpio is called full worm, and the medicinal elite of scorpio is main
It is scorpion venom, has the function of " antispastic cramp and relieves dizziness, anti-inflammatory and attacked poison are removed obstruction in channels to relieve pain ".
In we, using centipede and scorpio as monarch drug in a prescription, using Rhizoma Chuanxiong as ministerial drug, using safflower as adjutant, using frankincense and myrrh as
Make medicine, according to monarch, minister, the medication theory helped, made in traditional Chinese medicine, by each component in formula according to medicine made of rational proportion
Cream, in use, being sticked on Shen Shu point, shen shu, kidney, kidney.Yu, it is defeated.Shen shu name means the cold-dampness aqueous vapor of kidney
Thus outer defeated bladder warp.It is cold then first rush down mend afterwards or the moxibustion of benefit it, it is hot then rush down it.Under the action of the efficacy of a drug, by patient's body shen shu
The cold-dampness aqueous vapor passed in cave by kidney prevents outer defeated bladder warp, and by being excreted after renal blood flow metabolism.
And the ointment in small emplastrum is made of Caulis Spatholobi, rhizoma zingiberis, borneol, Caulis Spatholobi, has promoting circulation of blood and enriching blood, clearing and activating the channels and collaterals
Effect；Rhizoma zingiberis, acrid flavour, property heat, returns spleen, stomach, kidney, the heart, lung channel have the effect of warming spleen and stomach for dispelling cold, Back to Yang Tongmai, Wenfei of drink；
Borneol gas faint scent, it is acrid flavour, cool；Has volatility, " main trusted subordinate's perverse trend, rheumatism accumulation, deaf, hot eyes skin screen is gone in improving eyesight.”
In use, small emplastrum is pasted on Weizhong point, Weizhong point is located at human body popliteal bands midpoint, works as biceps femoral muscle
With the centre of semitendinosus tendon；In committee, entrust, accumulation.In, refer to where qi and blood in cave for day people the middle part of three.The cave
Name means that the damp and hot aqueous vapor of bladder warp is assembled herein.This cave substance is the wet gas of the water of the bladder warp each cave uplink in portion at one's knees, to inhale
The gas of uplink after heat is the shape of aggregation in this cave, in therefore named committee.In we, rhizoma zingiberis and borneol are as monarch drug in a prescription, to assembling in cave
The wet gas of water and rheumatism carry out eliminating cold to remove dampness, Caulis Spatholobi aids in progress promoting circulation of blood clearing and activating the channels and collaterals as adjuvant simultaneously.
By a kind of primary and secondary emplastrum for treating rheumatism provided by the invention, big emplastrum stick on Shen Shu point prevent in by
The cold-dampness aqueous vapor that kidney passes over prevents outer defeated bladder warp, and by being excreted after renal blood flow metabolism.Meanwhile small emplastrum
By the gas clearing damp cold dispelling that the water for coming into bladder warp is wet, and promoting circulation of blood clearing and activating the channels and collaterals, the two combine can thoroughly effect a radical cure rheumatism and
Rheumatoid arthritis.
Further, the ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：11-14 parts of frankincense,
13-18 parts of myrrh, 10-14 parts of Rhizoma Chuanxiong, 12-17 parts of safflower, 9-11 parts of centipede, 10-13 parts of scorpio.
Further, the ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：9-11 parts of Caulis Spatholobi,
7-10 parts of rhizoma zingiberis, 7-10 parts of borneol.
Further, the ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：12 parts of frankincense, myrrh
15 parts, 12 parts of Rhizoma Chuanxiong, 15 parts of safflower, 10 parts of centipede, 12 parts of scorpio.
Further, the ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10 parts of Caulis Spatholobi does
9 parts of ginger, 8 parts of borneol.
Further, the ventilative patch is selected any one in elastical cloth, APP colours of skin cloth, grey cotton fiber blend cloth
Kind, hypo-allergenic bonding agent is coated on one side to be made.
The present invention also provides a kind of method for the primary and secondary emplastrum for treating rheumatism is prepared, comprise the following steps：
A. according to preset weight number take the frankincense of the proportioning, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio, Caulis Spatholobi,
Rhizoma zingiberis, borneol；
B. the frankincense of the number, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio are carried out after tentatively processing, adds water to cook 70-
After 100 minutes, cool filtered to room temperature extracts the first filtrate；
C. first filtrate is concentrated to give the first ointment；
D. first ointment obtained is coated in ventilative patch and the big emplastrum is made；
E. it is cool to room temperature filtering the second filter of extraction after water intense fire directly being added to boil 40-55 minutes the Caulis Spatholobi, rhizoma zingiberis
Liquid；
F. obtained second filtrate is concentrated to give the second ointment；
G. second ointment obtained is coated in the ventilative patch and the sub- emplastrum is made.
It is provided by the invention to prepare a kind of method for the primary and secondary emplastrum for treating rheumatism, the spy of the various drug ingedients of close fit
Property, it is processed according to suitable method, the utilization rate of bulk pharmaceutical chemicals can be greatly improved by this method, keep raw material pharmaceutically active ingredient
Activity, bulk pharmaceutical chemicals effective rate of utilization reaches 90%.
Further, in step b, the preliminary processing specifically includes：The centipede of the number and scorpio are dried together
Afterwards, grind into powder；
The Rhizoma Chuanxiong of the number is cut into the segment of 1-2cm long；
Safflower and myrrh are dried, myrrh is smashed.
Further, in step b, add water to cook 70-100 minutes and specifically include：By the centipede after tentatively processing, entirely
Scorpion, Rhizoma Chuanxiong, safflower, myrrh and frankincense add water intense fire to cook 20-30 minutes, small fire cooking afterwards 50-70 minutes.
Further, in step e, water intense fire is added to boil 40-55 minutes and is specifically included：By the Caulis Spatholobi,
After rhizoma zingiberis directly adds water intense fire to boil 30-40 minutes, add in borneol and continue intense fire tanning 10-15 minutes.
Application method：To simultaneously big emplastrum be pasted on Shen Shu point, sub- emplastrum is pasted on to Weizhong point, and not paste that stick 5-6 small
When, 3-5 patches are as a treatment course.It is better using hot towel auxiliary warm during sticking.Use no taboo.
Compared with prior art, beneficial effects of the present invention are：
(1) big emplastrum and sub- emplastrum are used cooperatively, it is from traditional Chinese medical science human mechanism, the in vivo cold-dampness aqueous vapor of people is thorough
Removal, and promoting circulation of blood clearing and activating the channels and collaterals, can thoroughly effect a radical cure rheumatism and rheumatoid arthritis；
(2) it is quick, and will not be repeatedly after healing；
(3) treatment cost is low, and patient's use is without financial burden.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person, the condition suggested according to normal condition or manufacturer carry out.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
A kind of primary and secondary emplastrum for treating rheumatism, including the big emplastrum being used cooperatively and sub- emplastrum, the big emplastrum and son paste
Cream is made of ventilative patch and the ointment being attached in the ventilative patch；
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10-18 parts of frankincense, myrrh 10-20
Part, 8-15 parts of Rhizoma Chuanxiong, 10-20 parts of safflower, 7-13 parts of centipede, 8-15 parts of scorpio；
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：8-12 parts of Caulis Spatholobi, rhizoma zingiberis 5-13
Part, 6-12 parts of borneol.
A kind of primary and secondary emplastrum for treating rheumatism provided by the invention, wherein the plaster on big emplastrum is by frankincense, myrrh, river
Rhizome of chuanxiong, safflower, centipede, full worm, scorpio are made, and wherein frankincense, pungent, bitter, temperature, primary efficacy be used for promoting blood circulation and stopping pain, muscle arteries and veins contraction,
Traumatic injury, sore, carbuncle and painful swelling, detumescence and promoting granulation；Myrrh, primary efficacy are to dissipate blood and dissolving stasis, detumescence ding-tong, ulcer sore pain；Rhizoma Chuanxiong, it is pungent
It is warm fragrant dry, it walks without keeping, can go scattered, uplink is pushed up up to mountain peak, and enters blood system, and for downlink up to the sea of blood, promoting blood circulation effect is extensive,
Suitable for the various illnesss of stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness are favourable.Safflower, invigorate blood circulation, removing blood stasis and analgesics, have it is promoting blood circulation and removing blood stasis, dissipate it is wet
Go the effect of swollen；The effect of centipede has wind-dispelling, and poison is attacked in arresting convulsion, dissipating bind；Scorpio is called full worm, and the medicinal elite of scorpio is main
It is scorpion venom, has the function of " antispastic cramp and relieves dizziness, anti-inflammatory and attacked poison are removed obstruction in channels to relieve pain ".
In we, using centipede and scorpio as monarch drug in a prescription, using Rhizoma Chuanxiong as ministerial drug, using safflower as adjutant, using frankincense and myrrh as
Make medicine, according to monarch, minister, the medication theory helped, made in traditional Chinese medicine, by each component in formula according to medicine made of rational proportion
Cream, in use, being sticked on Shen Shu point, shen shu, kidney, kidney.Yu, it is defeated.Shen shu name means the cold-dampness aqueous vapor of kidney
Thus outer defeated bladder warp.It is cold then first rush down mend afterwards or the moxibustion of benefit it, it is hot then rush down it.Under the action of the efficacy of a drug, by patient's body shen shu
The cold-dampness aqueous vapor passed in cave by kidney prevents outer defeated bladder warp, and by being excreted after renal blood flow metabolism.
And the ointment in small emplastrum is made of Caulis Spatholobi, rhizoma zingiberis, borneol, Caulis Spatholobi, has promoting circulation of blood and enriching blood, clearing and activating the channels and collaterals
Effect；Rhizoma zingiberis, acrid flavour, property heat, returns spleen, stomach, kidney, the heart, lung channel have the effect of warming spleen and stomach for dispelling cold, Back to Yang Tongmai, Wenfei of drink；
Borneol gas faint scent, it is acrid flavour, cool；Has volatility, " main trusted subordinate's perverse trend, rheumatism accumulation, deaf, hot eyes skin screen is gone in improving eyesight.”.
In use, small emplastrum is pasted on Weizhong point, Weizhong point is located at human body popliteal bands midpoint, works as biceps femoral muscle
With the centre of semitendinosus tendon；In committee, entrust, accumulation.In, refer to where qi and blood in cave for day people the middle part of three.The cave
Name means that the damp and hot aqueous vapor of bladder warp is assembled herein.This cave substance is the wet gas of the water of the bladder warp each cave uplink in portion at one's knees, to inhale
The gas of uplink after heat is the shape of aggregation in this cave, in therefore named committee.In we, rhizoma zingiberis and borneol are as monarch drug in a prescription, to assembling in cave
The wet gas of water and rheumatism carry out eliminating cold to remove dampness, Caulis Spatholobi aids in progress promoting circulation of blood clearing and activating the channels and collaterals as adjuvant simultaneously.
By a kind of primary and secondary emplastrum for treating rheumatism provided by the invention, big emplastrum stick on Shen Shu point prevent in by
The cold-dampness aqueous vapor that kidney passes over prevents outer defeated bladder warp, and by being excreted after renal blood flow metabolism.Meanwhile small emplastrum
By the gas clearing damp cold dispelling that the water for coming into bladder warp is wet, and promoting circulation of blood clearing and activating the channels and collaterals, the two combine can thoroughly effect a radical cure rheumatism and
Rheumatoid arthritis.
Preferably, the ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：11-14 parts of frankincense does not have
13-18 parts of medicine, 10-14 parts of Rhizoma Chuanxiong, 12-17 parts of safflower, 9-11 parts of centipede, 10-13 parts of scorpio.
Preferably, the ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：9-11 parts of Caulis Spatholobi does
7-10 parts of ginger, 7-10 parts of borneol.
Preferably, the ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：12 parts of frankincense, myrrh 15
Part, 12 parts of Rhizoma Chuanxiong, 15 parts of safflower, 10 parts of centipede, 12 parts of scorpio.
Preferably, the ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10 parts of Caulis Spatholobi, rhizoma zingiberis
9 parts, 8 parts of borneol.
Preferably, any one in elastical cloth, APP colours of skin cloth, grey cotton fiber blend cloth is selected in the ventilative patch,
Hypo-allergenic bonding agent is coated on one side to be made.
The present invention also provides a kind of method for the primary and secondary emplastrum for treating rheumatism is prepared, comprise the following steps：
A. according to preset weight number take the frankincense of the proportioning, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio, Caulis Spatholobi,
Rhizoma zingiberis, borneol；
B. the frankincense of the number, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio are carried out after tentatively processing, adds water to cook 70-
After 100 minutes, cool filtered to room temperature extracts the first filtrate；
Preferably, the preliminary processing specifically includes：After the centipede of the number and scorpio are dried together, pulverize
End；
The Rhizoma Chuanxiong of the number is cut into the segment of 1-2cm long；
Safflower and myrrh are dried, myrrh is smashed.
Preferably, add water to cook 70-100 minutes and specifically include：By the centipede, scorpio, Rhizoma Chuanxiong, red after preliminary process
Flower, myrrh and frankincense add water intense fire to cook 20-30 minutes, small fire cooking afterwards 50-70 minutes.
C. first filtrate is concentrated to give the first ointment；
D. first ointment obtained is coated in ventilative patch and the big emplastrum is made；
E. it is cool to room temperature filtering the second filter of extraction after water intense fire directly being added to boil 40-55 minutes the Caulis Spatholobi, rhizoma zingiberis
Liquid；
Preferably, water intense fire is added to boil 40-55 minutes to specifically include：Water intense fire is directly added to endure the Caulis Spatholobi, rhizoma zingiberis
After 30-40 minutes processed, add in borneol and continue intense fire tanning 10-15 minutes.
F. obtained second filtrate is concentrated to give the second ointment；
G. second ointment obtained is coated in the ventilative patch and the sub- emplastrum is made.
It is provided by the invention to prepare a kind of method for the primary and secondary emplastrum for treating rheumatism, the spy of the various drug ingedients of close fit
Property, it is processed according to suitable method, the utilization rate of bulk pharmaceutical chemicals can be greatly improved by this method, keep raw material pharmaceutically active ingredient
Activity, bulk pharmaceutical chemicals effective rate of utilization reaches 90%.
Application method：To simultaneously big emplastrum be pasted on Shen Shu point, sub- emplastrum is pasted on to Weizhong point, and not paste that stick 5-6 small
When, 3-5 patches are as a treatment course.It is better using hot towel auxiliary warm during sticking.Use no taboo.
Embodiment 1
A kind of primary and secondary emplastrum for treating rheumatism, including the big emplastrum being used cooperatively and sub- emplastrum, the big emplastrum and son paste
Cream is made of ventilative patch and the ointment being attached in the ventilative patch；
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10 parts of frankincense, 10 parts of myrrh, Rhizoma Chuanxiong
8 parts, 10 parts of safflower, 7 parts of centipede, 8 parts of scorpio；
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：8 parts of Caulis Spatholobi, 5 parts of rhizoma zingiberis, borneol
6 parts.
Preparation method is as follows：
A. according to preset weight number take the frankincense of the proportioning, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio, Caulis Spatholobi,
Rhizoma zingiberis, borneol；
B. the frankincense of the number, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio are carried out after tentatively processing, adds water to cook 70
After minute, cool filtered to room temperature extracts the first filtrate；
C. first filtrate is concentrated to give the first ointment；
D. first ointment obtained is coated in ventilative patch and the big emplastrum is made；
E. the Caulis Spatholobi, rhizoma zingiberis are directly added into the tanning of water intense fire after forty minutes, cool filtered to room temperature extracts the second filtrate；
F. obtained second filtrate is concentrated to give the second ointment；
G. second ointment obtained is coated in the ventilative patch and the sub- emplastrum is made.
Embodiment 2
A kind of primary and secondary emplastrum for treating rheumatism, including the big emplastrum being used cooperatively and sub- emplastrum, the big emplastrum and son paste
Cream is made of ventilative patch and the ointment being attached in the ventilative patch；
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：18 parts of frankincense, 20 parts of myrrh, Rhizoma Chuanxiong
15 parts, 20 parts of safflower, 13 parts of centipede, 15 parts of scorpio；
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：12 parts of Caulis Spatholobi, 13 parts of rhizoma zingiberis, ice
12 parts of piece.
Preparation method is as follows：
A. according to preset weight number take the frankincense of the proportioning, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio, Caulis Spatholobi,
Rhizoma zingiberis, borneol；
B. the frankincense of the number, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio are carried out after tentatively processing, adds water to cook 100
After minute, cool filtered to room temperature extracts the first filtrate；
C. first filtrate is concentrated to give the first ointment；
D. first ointment obtained is coated in ventilative patch and the big emplastrum is made；
E. after water intense fire directly being added to boil 55 minutes the Caulis Spatholobi, rhizoma zingiberis, cool filtered to room temperature extracts the second filtrate；
F. obtained second filtrate is concentrated to give the second ointment；
G. second ointment obtained is coated in the ventilative patch and the sub- emplastrum is made.
Embodiment 3
A kind of primary and secondary emplastrum for treating rheumatism, including the big emplastrum being used cooperatively and sub- emplastrum, the big emplastrum and son paste
Cream is made of ventilative patch and the ointment being attached in the ventilative patch；
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：12 parts of frankincense, 15 parts of myrrh, Rhizoma Chuanxiong
12 parts, 15 parts of safflower, 10 parts of centipede, 12 parts of scorpio；
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10 parts of Caulis Spatholobi, 9 parts of rhizoma zingiberis, ice
8 parts of piece.
Preparation method is as follows：
A. according to preset weight number take the frankincense of the proportioning, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio, Caulis Spatholobi,
Rhizoma zingiberis, borneol；
B. after the centipede of the number and scorpio being dried together, grind into powder；The Rhizoma Chuanxiong of the number is cut into 1-
The segment of 2cm long；Safflower and myrrh are dried, myrrh is smashed；Afterwards, water intense fire is added to cook after twenty minutes, is boiled with soft fire
System 50 minutes, cool filtered to room temperature extract the first filtrate；
C. first filtrate is concentrated to give the first ointment；
D. first ointment obtained is coated in ventilative patch and the big emplastrum is made；
E. after water intense fire directly being added to boil 30 minutes the Caulis Spatholobi, rhizoma zingiberis, add in borneol and continue 10 points of intense fire tanning
Zhong Hou, cool filtered to room temperature extract the second filtrate；
F. obtained second filtrate is concentrated to give the second ointment；
G. second ointment obtained is coated in the ventilative patch and the sub- emplastrum is made.
Experimental example 1
By the primary and secondary emplastrum provided in above-described embodiment 1-3 and presently commercially available rheumatic plaster allow 30 patient's rheumatism with
And rheumatoid disease patient, respectively using 5 days, result statistics is as follows：
Wherein, test group one：10 patients are slight rheumatism, and symptom is slight gonalgia, test group two：10
Patient is rheumatoid arthritis, and morning posterior joint of getting up is stiff, and there has been mild malformation in some patientss joint；Test group
Three：10 be that patient is the patient with severe symptoms with rheumatic arthritis 5 years or more, in above-mentioned three groups of patients, wherein 5 people use this hair
The primary and secondary emplastrum of bright offer, 5 people use commercially available rheumatic plaster.
According to the comparison of above-mentioned statistics it will be clear that the primary and secondary for taking 1-3 of embodiment of the present invention offers pastes
For treating the primary and secondary emplastrum of rheumatism made of cream and preparation method thereof, for slight rheumatisant, cure rate reaches
100%, and presently commercially available plaster for curing rheumatism its cure rate is only 60% or so, in the treatment for rheumatoid disease and severe rheumatism
Aspect, letter emplastrum provided by the invention, obvious effective rate have also reached 100%, and presently commercially available plaster for curing rheumatism its obvious effective rate
Only 70% or so, it is seen then that it is provided by the invention treatment rheumatism alphabetical emplastrum the effect of it is notable.
And above-mentioned rheumatoid arthritis and severe rheumatoid-arthritis patient continued within subsequent one month
Using this product, its symptom of 80% patient significantly mitigates, the stiff anesthesia from morning.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (9)
1. a kind of primary and secondary emplastrum for treating rheumatism, which is characterized in that it is made of the big emplastrum and sub- emplastrum that are used cooperatively, it is described big
Emplastrum and sub- emplastrum are made of ventilative patch and the ointment being attached in the ventilative patch；
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10-18 parts of frankincense, 10-20 parts of myrrh, river
8-15 parts of rhizome of chuanxiong, 10-20 parts of safflower, 7-13 parts of centipede, 8-15 parts of scorpio；
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：8-12 parts of Caulis Spatholobi, 5-13 parts of rhizoma zingiberis, ice
6-12 parts of piece.
2. a kind of primary and secondary emplastrum for treating rheumatism according to claim 1, which is characterized in that
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：11-14 parts of frankincense, 13-18 parts of myrrh, river
10-14 parts of rhizome of chuanxiong, 12-17 parts of safflower, 9-11 parts of centipede, 10-13 parts of scorpio.
3. a kind of primary and secondary emplastrum for treating rheumatism according to claim 1, which is characterized in that
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：9-11 parts of Caulis Spatholobi, 7-10 parts of rhizoma zingiberis, ice
7-10 parts of piece.
4. a kind of primary and secondary emplastrum for treating rheumatism according to claim 1, which is characterized in that
Ointment on the big emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：12 parts of frankincense, 15 parts of myrrh, Rhizoma Chuanxiong 12
Part, 15 parts of safflower, 10 parts of centipede, 12 parts of scorpio.
5. a kind of primary and secondary emplastrum for treating rheumatism according to claim 1, which is characterized in that
Ointment on the sub- emplastrum is made of the bulk pharmaceutical chemicals of following parts by weight：10 parts of Caulis Spatholobi, 9 parts of rhizoma zingiberis, borneol 8
Part.
6. a kind of primary and secondary emplastrum for treating rheumatism according to claim 1, which is characterized in that
Any one in elastical cloth, APP colours of skin cloth, grey cotton fiber blend cloth is selected in the ventilative patch, in one side
Hypo-allergenic bonding agent is coated on face to be made.
7. prepare a kind of method for the primary and secondary emplastrum for treating rheumatism of claim 1-6 any one of them, which is characterized in that including
Following steps：
A. the frankincense of the proportioning, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio, Caulis Spatholobi, dry is taken according to preset weight number
Ginger, borneol；
B. the frankincense of the number, myrrh, Rhizoma Chuanxiong, safflower, centipede, scorpio are carried out after tentatively processing, adds water to cook 70-100
After minute, cool filtered to room temperature extracts the first filtrate；
C. first filtrate is concentrated to give the first ointment；
D. first ointment obtained is coated in ventilative patch and the big emplastrum is made；
E. after water intense fire directly being added to boil 40-55 minutes the Caulis Spatholobi, rhizoma zingiberis, cool filtered to room temperature extracts the second filtrate；
Water intense fire is added to boil 40-55 minutes to specifically include：After water intense fire directly being added to boil 30-40 minutes the Caulis Spatholobi, rhizoma zingiberis, add
Enter borneol and continue intense fire tanning 10-15 minutes；
F. obtained second filtrate is concentrated to give the second ointment；
G. second ointment obtained is coated in the ventilative patch and the sub- emplastrum is made.
8. according to claim 7 prepare a kind of method for the primary and secondary emplastrum for treating rheumatism, which is characterized in that
In step b, the preliminary processing specifically includes：After the centipede of the number and scorpio are dried together, grind into powder；
The Rhizoma Chuanxiong of the number is cut into the segment of 1-2cm long；
Safflower and myrrh are dried, myrrh is smashed.
9. according to claim 7 prepare a kind of method for the primary and secondary emplastrum for treating rheumatism, which is characterized in that
In step b, add water to cook 70-100 minutes and specifically include：By after preliminary process the centipede, scorpio, Rhizoma Chuanxiong, safflower,
Myrrh and frankincense add water intense fire to cook 20-30 minutes, small fire cooking afterwards 50-70 minutes.
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| CN108498634A (en) * | 2017-11-01 | 2018-09-07 | 王健民 | A kind of externally applied drug of rheumatoid arthritis and its preparation method and application |
| CN113209182B (en) * | 2021-06-28 | 2022-06-17 | 辽宁中医药大学附属医院 | A Chinese medicinal composition for treating rheumatoid arthritis, and its preparation method |
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| CN1063659C (en) * | 1998-08-26 | 2001-03-28 | 泰安市中医医院 | Chinese plaster for curing liver diseases and its preparation method |
| CN1085550C (en) * | 1999-12-22 | 2002-05-29 | 尹霞林 | Medicine for rheumatism and its preparation |
| CN1288740A (en) * | 2000-10-16 | 2001-03-28 | 史友明 | Preparation of rheumatism-eliminating and pain-relieving plaster |
| CN1843443A (en) * | 2005-04-06 | 2006-10-11 | 王传芳 | Rheumatoid disease treating plaster |
| CN1772045A (en) * | 2005-10-19 | 2006-05-17 | 要维娜 | Rheumatism treating medicine |
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