CN104544052A - Lycium ruthenicum murr buccal tablet capable of protecting eyesight and improving eyesight - Google Patents
Lycium ruthenicum murr buccal tablet capable of protecting eyesight and improving eyesight Download PDFInfo
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Abstract
The invention provides a lycium ruthenicum murr buccal tablet capable of protecting eyesight and improving eyesight. The lycium ruthenicum murr buccal tablet is high-level healthy food or healthcare food. The lycium ruthenicum murr buccal tablet is prepared from the raw materials such as pollution-free high-quality natural medical and edible dual purpose plant lycium ruthenicum murr from Tibet Plateau, longan aril, semen sesami nigrum, mulberry, pericarpium citri reticulatae, alpha-linolenic acid, xanthophylls, beta-carotene, vitamin A, vitamin E, vitamin C, zinc, chromium and selenium. The lycium ruthenicum murr buccal tablet has the effects of nourishing the kidney and strengthening the essence, nourishing the liver to improve visual acuity, strengthening the spleen and stomach and nourishing blood, and has the special effects on adjusting immunity, preventing and treating shortsightedness and pseudomyopia, treating nutritional amblyopia, preventing the development of pseudomyopia to true myopia, allaying tiredness, visual impairment, glaucoma, presbyopia, cataract and macular degeneration, and preventing the damage of diabetes to eyesight; the tablet is prepared by the process comprising the following steps: mixing raw materials; agitating; preforming; inspecting after being qualified; and packaging to obtain the formal product.
Description
One, technical field: the invention belongs to high-end healthy food or health food, especially with raw materials such as the black matrimony vine of the natural pollution-free high-quality medicine food dual purpose plant in Qinghai-Tibet Platean, arillus longan, mulberry fruit, Semen sesami nigrum, dried orange peel, alpha-linolenic acid, lutein, beta carotene, VitAVitE, vitamin C, zinc, chromium, selenium, the healthy food taking modern advanced technologies to process or health food.
Two, background technology: the healthy food that this invention is made with raw materials such as black matrimony vine, arillus longan, Semen sesami nigrum, mulberry fruit, dried orange peel, alpha-linolenic acid, lutein, beta carotene, VitAVitE, vitamin C, zinc, chromium, selenium or health food.This product has tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity, strengthening spleen and nourishing stomach, the effect such as nourish blood, have immunity moderation power, anti-oxidant, control myopia, pseudo-myopia, treatment nutritional amblyopia, prevent pseudomyopia to true myopia progression, anti-eye strain, vision disorder, glaucoma, presbyopia, cataract, age-related macular degeneration, prevent the injury of diabetes to eyesight from having special effect.Also this product does not occur in the market, and this product of innovation development, can be and improve the eye illnesses such as eyesight to children and adolescents and provide a kind of new product, this product is lozenge, and belong to pure natural extract, purity is high, good absorbing, biologically active are strong, have no side effect, taking convenience, successful.
Three, summary of the invention: vision protection, cherish life.Along with China's science and technology and economic fast development, working and learning pressure strengthens and bad habits and customs, cause the factors such as the improper and dietary structure of the long-time close eye of children is unreasonable, in addition the development with the network industry popularized by electronic game machine, computer, plays games for a long time, surfs the Net, sees that TV etc. exacerbates the impact on children and youth eyesight.Make the children and youth of China myopia number increase year by year, and present the trend of younger ones in an age groupization.According to authoritative department statistics, there is A nearsighted person about 300,000,000 people in current China, and amblyopia more than 1,000 ten thousand, the myopia of student incidence of disease is 60%, ranks first in the world.Visible myopia and amblyopia are quite serious children ' s vision health problems, are even related to the happiness in their all one's life.Thus, also actively effectively should must carry out prevention and therapy to the myopia of children and youth and amblyopia, and pick up from juvenile, pupil.Therefore, this product of innovation research and development is eliminated the eye illnesses such as kopiopia have great importance to control children and youth myopia, amblyopia.
Four, composition of raw materials: black matrimony vine extract 10-70 kilogram, longan extract 10-50 kilogram, mulberry extract 10-40 kilogram, Semen sesami nigrum extract 10-80 kilogram, dried orange peel extract 10-60 kilogram, alpha-linolenic acid 10-50 kilogram, lutein 0.1-0.6 kilogram, beta carotene 10-15 gram, retinol1 0-60 gram, vitamin E 0.2-0.8 kilogram, vitamin C 10-40 kilogram, zinc 0.12-0.6 kilogram, chromium 12-30 milligram, selenium 10-60 milligram, auxiliary material be raw material.
Five, technical scheme:
(1) black matrimony vine extract: (Lyciam barbarnm extraat), black matrimony vine grows at Qinghai-Tibet green ecological environment, the black matrimony vine dry fruit of pure natural treasure medicine food dual purpose plant.Black matrimony vine is a kind of high-end invigorant of ecosystem of rare preciousness.Black matrimony vine is matrimony vine of solanaceae plant ripening fruits.Property is put down, and taste is sweet.Return liver, kidney channel.There is effect of nourishing liver and kidney, benefiting shrewd head, moistening lung.Lose for consumptive disease essence, soreness of waist and knee joint, dizzy tinnitus, interior heat is quenched one's thirst, the deficiency of blood is sallow, improve eyesight, blurred vision is not clear.Modern medicine study is thought, black matrimony vine has develop immunitypty, antifatigue, hypotensive, reducing blood lipid, hypoglycemic, protection liver, fat-reducing, the function such as anti-ageing, anticancer.
Chemical composition: black matrimony vine is containing trace elements such as multivitamin and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalt such as polysaccharide, amino acid, betaine, carrotene, Cobastab, vitamin C, nicotinic acid.And also have abundant natural procyanidins, wherein procyanidin content is the several times of blueberry content, is the wild plant finding that procyanidin content is the highest up to now.
Pharmacological action: 1, develop immunitypty: mouse gavaging water extract or intramuscular injection alcohol extract all significantly can strengthen the phagocytic activity of its reticuloendothelial system to india ink.Water extract or LBP-X all can promote lysozyme activity in Phagocytosis By The Peritoneal Macrophages In Mice and serum.Give normal or Aged Mice gavages or abdomen LBP-X, can significantly strengthen peritoneal macrophage c
3the acceptor number of b and Fc and vigor, can make Aged Mice suppressor T lymphocyte regulate antibody function to return to the level of adult mice.Black LBP-X sterling has more significant immune response effect than crude product, every immune indexes (comprise the serum hemolysin of the immune organ quality of nospecific immunity, macrophage phagocytic effect, specific humoral immunity, moving back hair style allergy, lymphocyte transformation rate, E red rose pigment etc. in specific cellular immunity) all has significant difference.
2, liver, AFL is protected: black wolfberry fruit extract has certain effect to protection liver and AFL tool.Modern medicine study finds, containing a kind of active ingredient-betaine in black matrimony vine, it is very effective to treatment liver diseases.Experiment shows, betaine has suppression fat to deposit in liver cell, promotes the effect of liver cell regeneration.In addition, the middle betaine of black matrimony vine can prevent excess fat storage in liver, has the effect of anti-fatty liver, it is reported, feeds water extract or betaine feed to ccl for a long time through rat
4the hepatic lesion caused has protective effect, obviously can reduce the change of lipid in transaminase and liver, can suppress lipidosis and promotion liver cell new life in liver, have significant protective effect to hepatic lipid peroxidation damage.
3, eyesight, anti-eye strain is improved: black matrimony vine contains abundant OPC, there is stronger anti-oxidation function, effectively can alleviate the infringement of radical pair eye lens, eye cell and retina can be protected, promote rhodopsin cytothesis, improve visual acuity, accelerate the speed of visual accommodation ability and the vision restoration after glistening in dark, promote ocular circulation; Relieving eye strain.To myopia, amblyopia, cataract, photophobia, patients with retinitis pigmentosa, there is good preventive and therapeutic effect.Someone is to the 75 eye fatigue patients of example because working before display screen for a long time, and give appropriate OPC every day, after 2 months, its proportional sensitivity and nbjective symptom are all significantly improved.Take 2 months to 200 Myopia retina non-inflammatory patients, its result experimenter eyesight significantly improves.According to another report, black matrimony vine has and nourishes the liver to improve visual acuity, and improves the effect of eyesight.Clinical medicine report display, OPC can promote the regeneration of the rhodopsin in retina cell; Laser high myopia and detached retina can be prevented and treated, and improve eyesight.According to France, researcher proves, OPC obviously can improve the subjective symptoms of eye fatigue.Obvious effect is had to computer program staff, clerical workforce and the calibrating of Eyes of Students fatigue.The U.S. reports, anthocyanidin is classified as the effect that pupil has protection eyes by the U.S., prevents the generation of the disease such as myopia development and retinal detachment.Especially the personnel of work before computer, see TV for a long time, play games and the people of the blurring of image.
4, age-related macular degeneration is prevented and treated: black matrimony vine has obvious preventive and therapeutic effect to eye illnesses such as chronic liver disease, central retinitis, optic atrophies.Contribute to the effect reducing age-related macular degeneration.Age-related macular degeneration is the topmost reason of over-65s patient DE.Macula lutea is mainly made up of zeaxanthin, and this material contributes to anti-oxidant, and absorbs the blue light of easily infringement eye cell and tissue.Research finds, black wolfberry fruit extract can reduce the probability that the elderly suffers from degeneration macular degeneration.Participate in 27 men and women of clinical research, wherein 14 people take black matrimony vine in continuous 28 days, all the other people take water, researcher was the blood drawings on an empty stomach of two groups of numbers at 29 days, find that the continuous 28 days zeaxanthins taken in one group of blood of black matrimony vine add 2.5 times before comparatively testing, and control group does not increase.
5, presbyopia is prevented and treated: black wolfberry fruit extract has the oxidation resistant effect of tonifying liver improving eyesight.The infringement of radical pair eye lens can be alleviated, protection eye cell and retina, control presbyopia.
(2), longan extract (Arillus lingan), have another name called longan.For the mature sarcocarp of sapindaceous plant longan.Warm in nature.The thoughts of returning home, the spleen channel, have nourishing blood and tranquilization, tonifying heart and spleen.For insufficiency of vital energy and blood, the effect such as palpitation and severe palpitation, forgetful insomnia, anaemia are sallow.Modern medicine study is thought, arillus longan has raising immunity, control myopia, anti-visual fatigue, improving water flood and anaemia, enhancing development, resist oxygen lack, anti-oxidant, delay senility, lose weight, acne of dispelling and chloasma, assist the effects such as Tumor suppression.
Chemical composition: arillus longan is containing glucose, sucrose, organic acid; Protein, fat, adenine, choline and multivitamin.
Pharmacological action: 1, vision protection and control myopia: Arillus Longan extract can alleviate the infringement of radical pair eye lens, protection eyes and retina, improves long-time operation computer, sees TV, Play Station games and mobile phone be to the injury of eyes.Research also finds, Arillus Longan extract can strengthen Retinal sensitivity, and eyes visual acuity can be made to improve, and shows as visual acuity, not easily myopia.Zoopery shows, Arillus Longan extract can make rat retina albedo strengthen, and the correct response actual with study to brightness discrimination significantly improves, and has and improves visual performance, the effect of control myopia.
2, improve immunity: obviously can increase spleen weight to mouse gavaging arillus longan decoction, improve mouse carbon granule corridor and refer to clearly increase number, develop immunitypty.
3, hematopoietic function is promoted: Arillus Longan extract has promotion and growth to hematopoietic cell.Experiment proves, the recovery of arillus longan to the red blood cell of anemia mice, hemoglobin, leucocyte and femur karyocyte has significant facilitation.Separately have report, arillus longan also has significant facilitation to myeloid lineage proliferation of hematopoietic progenitors differentiation that is normal or anemia mice.
4, control insomnia, forgetful: motherland's medical science is thought, arillus longan has Appetizing spleen-tonifying, nourishing blood and tranquilization, establishing-Yang benefit effect such as gas, qi-restoratives intelligence development.The insomnia forgetfulness that clinical practice causes in the insufficiency of heart and spleen, insufficiency of vital energy and blood.Research shows, before sleeping every night, edible 5 pieces of arillus longans, have effect of mental-tranquilization.The very suitable insufficiency of heart and spleen causes insomnia and dreamful sleep person.
5, anti-visual fatigue: Arillus Longan extract to long-time operation computer, to play games and visual fatigue that mobile phone causes has certain antifatigue effect.
(3) Fructus Mori extract (Fnuetus mori) is the dry fruit ear of moraceae plants mulberry tree, cold in nature, taste is sweet, sour.The thoughts of returning home, liver, kidney channel.There is liver-kidney tonifying, nourishing yin and supplementing blood, effect of promoting the production of body fluid to quench thirst.Be applicable to the deficiency of liver-yin and kidney-yin, calm the nerves and nourish heart, dizzy tinnitus, palpitation and insomnia, to delay senility.Treatment poliosis, interior heat are quenched one's thirst, blood deficiency and constipation, vision protection.The pharmacological actions such as anti-visual fatigue.
Chemical composition: containing flavonoids, mulberry pigment, rutin total phospholipids, fragrant oil, organic acid, protein, amino acid, carbohydrate compound, vitamin, trace element, dietary fiber.
Pharmacological action: 1, strengthen immunologic function: Fructus Mori extract can strengthen the phagocytic function of animal macrophage, and have obvious facilitation to the cell (PFC) that the outer antibody of three monthly age Mice Bodies is formed, all there is humidification to the cellular immunity of animal and humoral immunity.Separately have report, " deficiency of Yin " mouse spleen lymphocyte that Fructus Mori extract can significantly improve concanavalin A induction strengthens ability, and IL-2 induced activity and NK cell killing rate, have enhancing immunologic function.
2, anti-oxidant: research finds, Fructus Mori extract has very strong antioxidation.The anthocyanin contained, rutin can reduce the generation of body metabolism refuse free radical, and to the crystallin oxidation that control free radical too much causes, phacoscotasmus and cataract have remarkable effect.
3, hemopoietic function of bone marrow is promoted: research shows, mulberry is to mouse skin note 0.2ml, totally 3 days every day 2 times, gavage endoxan 0.3mg/g again, diffusion chamber is imbedded one day in abdominal cavity, result Fructus Mori extract can make diffusion chamber CFU-D productive rate obviously increase, and shows there is facilitation to the growth of grain system CFU-GM.Further research finds, mulberry is to after Blood deficiency mouse gavaging, and its red blood cell, hemoglobin numerical value recovered normal in the 5th day, and the deficiency of blood symptom of mouse is obviously improved.Therefore, Fructus Mori extract can promote the growth of hematopoietic cell, and has facilitation to the growth of grain system CFU-GM.
4, eyeshield, improve visual fatigue: presbyopia shows as myopia and fades, to read and difficulty occurs near work, this is a kind of common aging phenomenon, but when suffering from some eye illness, presbyopia occurs that symptom is more serious ahead of time.The traditional Chinese medical science thinks that presbyopia is lost by kidney water, asthenia of essence and blood, and The liver and the kidney have a common source again, and liver opens surreptitiously in order, nourishing liver, invigorating kidney.And Fructus Mori extract can nourish liver, replenishing the vital essence and the blood, therefore, has the eye illnesses such as control myopia and presbyopia.In addition, Fructus Mori extract also has the asthenopic effect of improvement.
(4), Semen sesami nigrum extract (Semen sesami nigrum), be the mature seed of sesame flax plant.Property flat, taste is sweet.Return liver kidney, large intestine channel.There is the effects such as filling liver kidney, benefiting essence-blood, ease constipation.Be applicable to dizzy, Hiccough and deaf, poliosis, post disease alopecia, the dry constipation of intestines etc.Modern pharmacological research is thought, Semen sesami nigrum has vision protection, improves visual fatigue, protection liver, develop immunitypty, beautifying face and moistering lotion, eliminating chloasma, anti-oxidant, delay senility, Improving memory power, reducing blood lipid, the effect such as hypotensive.
Chemical composition: protein, aliphatic acid, sesamin, the compositions such as anthocyanin, flax glucoside, mineral matter, multivitamin, dietary fiber.
Pharmacological action: 1, control myopia and raising visual acuity: aliphatic acid forms amphiblestroid main component, has substantial connection, can promote that optic nerve is grown to eyesight.Childhood retinal development is the fastest, needs sufficient aliphatic acid, if aliphatic acid insufficiency of intake can affect one's power of vision, and even myopia, the eye illnesses such as amblyopia.And to preventing and treating myopia and improving eyesight, there is good effect containing abundant insatiable hunger conjunction aliphatic acid in Semen sesami nigrum.Inhibited to the change of children with myopia retinal abnormalities.In addition, by animal contrast experiment, the visual acuity test of scanning vision excitation potential (SVEP), result is apparently higher than control group, and Semen sesami nigrum has the effect improving and look acuity.
2, protect liver: zoopery proves, Semen sesami nigrum can liver-protectively act on.Containing a large amount of unrighted acids and abundant vitamin E in Semen sesami nigrum, blood fat and triglycerides can be reduced, eliminate the fat in liver, have certain therapeutic action to chronic hepatitis and fatty liver.
3, anti-visual fatigue: Semen sesami nigrum contains the compositions such as abundant mineral matter and multivitamin, to computer people and long time see TV, play games and mobile phone produce visual fatigue there is certain mitigation.
(5), dried orange peel extract (Pericarpium cleri Retlculatae), be the dry mature skin of rutaceae orange and various plants thereof.Warm in nature, bitter, pungent.Return lung, the spleen channel.
There is regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect., food depressed for abdominal cavity turgor, diet is few vomits and diarrhoea, coughing with a lot of sputum etc.Modern pharmacological research is thought, dried orange peel has develop immunitypty, vision protection, promotion digestion, clearing, antibacterial, antipathogen, anti-inflammatory, protects liver, anti-visual fatigue, protection stomach lining, anti-oxidant, Improving memory power, improve anaemia, reduce cholesterol, improve blood circulation, improve gut flora, constipation, the effect such as antitumor, eliminating chloasma and acne.
Chemical composition: containing citrene etc. in hesperetin, hesperidine, methyl hesperidine, hesperidine chalcone, hesperidine methyl chalcone, Pericarpium Citri Reticulatae volatile oil.
Pharmacological action: 1, improve eyesight, anti-visual fatigue: dried orange peel is to improving eyesight and visual fatigue has important function.Dried orange peel extracts is to maintenance institutional framework; improve eyes wall of micrangium; promote around eyes blood circulation; protection eyeball normal pressure; effectively can suppress the infringement to eye cell; protection eye capillary, strengthens the adaptive capacity to dark, the generation of the eye illnesses such as anti-eye strain, control myopia, amblyopia, presbyopia, cataract, macular degeneration.
2, immunologic function is strengthened: zoopery confirms, dried orange peel all has significant humidification to GPS lysozyme content, serum coagulation antibody titre, painstaking effort T lymphocyte E rose formation rate, illustrates that dried orange peel all has certain facilitation to humoral immunity and cellular immunity.
3, promote digestion: Pericarpium Citri Reticulatae volatile oil has gentle spread effect to intestines and stomach, can promote the secretion of saliva, Gastric juice digestion liquid, promote digestion, and pneumatosis in eliminating intestines can be impelled.
4, anti-oxidant: dried orange peel aqueous extract has the hyaluronic acid depolymerisation eliminated oxygen radical, suppress mouse liver peroxidatic reaction of lipid, lower oxonium ion induction, and it is active to resist body mouse liver adenosine deaminase.
5, antipathogen: dried orange peel is in vitro staphylococcus, and proteus, shigella dysenteriae, catarrh be bacterium, hemolytic bacillus acidophilus and influenza virus how, and vesicle oral inflammation all has inhibitory action.
6, anti-inflammatory: mouse peritoneal injection dried orange peel extracts can resist venomin, and histamine etc. cause vasopermeability to be increased and suppress rat crotons oiliness granulomatous inflammation and ooze out, and guinea pig bronchial spasm caused by prevention and therapy chloroethanes.
In addition, dried orange peel also has anti-gastric-ulcer, spasmolysis, improves blood circulation, norcholesterol and reducing blood lipid, cardioprotection, antiatherosclerosis, the effect such as antitumor.
(6) alpha-linolenic acid (α-tinolenic acid), alpha-linolenic acid is essential fatty acid, is the parent of omega-3 polyunsaturated fatty acids, is mainly present among linseed oil, Purple Perilla Seed Oil.Eicosapentaenoic acid (EPA) and DHA (DHA) can be converted in human body.Be the basic substance forming human tissue cell's film and biology enzyme, self can not synthesize and metabolism in human body, be essential fatty acid, can only absorb from food.Much research confirms; alpha-linolenic acid has develop immunitypty and intelligence, vision protection, control myopia, reduces blood fat, blood pressure and blood sugar, suppression hemorrhagic cerebral disease and thrombotic diseases, the generation of suppression cancer and transfer; prevention miocardial infarction, anaphylactia, inflammation and reducing human aging etc.Alpha-linolenic acid also can prevention and therapy diabetes, rheumatoid disease, depression, schizophrenia, senile dementia, allergy, asthma, ephrosis and chronic obstructive pneumonia etc.
Physiological function: 1, develop immunitypty: alpha-linolenic acid contributes to strengthening human immune system's function, essential fatty acid energy Protecting gene immune impairment in immune system, to enhancing body immunity, improves organism quality and has important effect.
2, visual performance and vision protection is improved: the aliphatic acid containing 53%-60% in the amphiblestroid Phospholipids of human body, can make retina cell limber up, improve amphiblestroid reflection function.Zoopery shows, and alpha-linolenic acid can make rat retina albedo strengthen, and significantly improves, have the effect improving visual performance to the correct response rate of brightness discrimination study experiment.Further research, it is many especially that the acromere in retina contains DHA, will decline if lack DHA eyesight, retinal reflex ability recovery time just extends, because retina lipid at a touch light, and will chemically reactive, the potential change produced therefrom, passes to brain by nerve again.Carry out the raising of two generations with the serial safflower oil of ω-6 and alpha-linolenic acid to rat respectively, result shows, and alpha-linolenic acid lacks then eyesight to be reduced.Existing discovery, high-purity alpha-linolenic acid, at pre-myopia prevention, anti-eye strain, prevents diabetes to the injury of eyesight.Treat dystrophic amblyopia, vision disorder, prevent pseudomyopia from having special effect to true myopia progression.
3, anti-inflammatory: research shows: alpha-linolenic acid has good antiinflammatory action.It is reported, inflammation is when occurring, and the arachidonic acid (AA) on cell membrane produces medium in a series of fat with physiologically active under the effect of Cycloxygenase and lipoxidase.Mainly comprising Prostaglandin PGE2 and four is that leukotriene (LT4) can cause inflammation reaction.The metabolite EPA of alpha-linolenic acid is the allied substances of two AA, producing Prostaglandin PGE3 and five by competition the same enzyme system is the generation that leukotriene (LT5) suppresses PGE2 and LT, as compared to PGE2 with LT4, PGE3 and LT5 does not almost act on inflammatory activity, therefore, alpha-linolenic acid has good antiinflammatory action.According to another report, Eskimos suffers from asthmatic tracheitis, rheumatic arthritis, lupus erythematosus etc. are starkly lower than local white people so that autoimmunity is abnormal for the chronic inflammation disease incidence of disease of reason, supplementary fish oil can alleviate the arthritis caused by collagen, fish oil has significant anti-dermatitis effect, can reduce the psoriatic incidence of disease.Zoopery finds, the animal of the EPA that feeds, its Experimental Inflammation oedema degree can obviously reduce.
(7) lutein (Lutein) has another name called Lutein.It is a kind of natural carotenoid be extensively present in green vegetables, is the important component forming the phytochromes such as corn, veterinary antibiotics, flowers.Have 8 kinds of isomers, based on alltrans, account for more than 80%, belong to lutein class together with zeaxanthin etc.Carotenoids is the internationally recognized natural materials with Physiological resistance function.Scientific research proves, lutein is except having protective effect to eyesight, and also have control myopia, cataract, Senile degenerative ARM, develop immunitypty, prevention of arterial harden, and especially to pre-anti-cancer, delay cancer development and have important effect.
Physiological function: 1, anti-oxidant: its major function of lutein makes effective quencher of singlet oxygen, can remove hydroxyl radical free radical, is the breaking antioxidants of peroxidatic reaction of lipid, plays an important role to the prevention of human body diseases.
2, vision protection: lutein is eye retina and the lenticular carotenoid be uniquely found is the primary pigments forming eye retina macular region.Blue light in the sun can filter by lutein contained in crystalline lens and macula retinae district, fall to prevent blue light to the injury of eyes, because blue light enters eyes can produce a large amount of free radicals, people is made to occur cataract, or make macular area degradation degeneration, so human body is once lack lutein, just there will be the symptoms such as senile retinal ARM, cataract, presbyopia, pseudo-myopia, amblyopia, visual fatigue.Research finds, lutein energy singlet-oxygen quenching, suppresses the generation of free radical, to polyunsaturated fatty acid in cell and be oxidized preventive effect.Therefore there is the effect of vision protection.
(8) beta carotene (β-Carotene), is be present in carrot, Ipomoea batatas, a Carotenoids mixture of the natural plants such as marine alga.Carrot have two kinds of forms to be existed, i.e. cis and trans, and cis has higher bioactive functions.Beta carotene is a kind of fat-soluble compound, can be converted into vitamin A in human body, is a kind of very strong antioxidant.Confirm according to the study, beta carotene has scavenging free radicals, anti-sudden change, protects cardiovascular, vision protection, cancer-resisting, delays senility, the functions such as beautifying face and moistering lotion.
Physiological function: 1, anti-sudden change, beta carotene can be protected and repair cell microsomal membrane complete, to stop generation and the destruction of superoxide radical, avoids DNA (DNA) double bond to damage, and stops the fall out effect that inhereditary material changes.
2, anti-oxidant: large quantity research confirms both at home and abroad, and the oxygen radical in body not only can damage normal cell, also can cause the distortion of cell and form cancer, and β-Hu Luoka element is free radical the strongest " jinx ".Beta carotene has quencher oxygen radical, associativity oxygen radical, forms the ability of non-free radical compound.The aliphatic acid of β-Hu Luoka element and cell membrane bilayer combines, to stop peroxidatic reaction of lipid.
3, develop immunitypty: the immune system of body is made up of immune organ and immunocyte and immune molecule.Beta carotene can promote to gulp down divination by means of the milfoil cell, lymphocyte, the function of panimmunity cell, promote the release of cell factor, bring out the information between specific response cell and immunocyte killing tumour cell, transmit the secretion of necessary factor, and beta carotene can improve the immunologic function of host cell, delay cell and body aging, reduce the generation of disease.
4, protect DNA: beta carotene can prevent DNA from damaging, and have the ability promoting to repair damage.After the fracture of mouse lymphocyte DNA chain, in cell culture fluid, add beta carotene, after cultivating, DNA break chain connects again.That supplements beta carotene is subject to the significantly low collator giving comfort group of its lymphocytic micronucleus cell micronuclear rates of envoy.And there is obvious negative correlation between the concentration all finding beta carotene in lymphocyte micronucleus rate and blood plasma in the front and back of supplementary beta carotene.
5, eyesight is improved: carrotene has the effect significantly improving eyesight.Research finds, beta carotene contributes to improving eyesight, prevents sunlight to amphiblestroid infringement.The similar half of beta carotene absorbed in human body is converted into the rhodopsin contributing to eyesight, has important effect for raising eyesight.According to another report, beta carotene can also vision protection.Zoopery confirms; eye eyesight depends on the macula lutea of eyes; if there is no enough beta carotenes; will retrogression pathological changes be there are in these positions; eyesight can be faded; even yctalopia can occur, and beta carotene has and prevents Senile degenerative ARM, plays the effect of vision protection.
(9) vitamin A (Vit A), has another name called retinol.It is the insatiable hunger monohydric alcohol be made up of 20 carbon and 40 carbon atoms.Comprise vitamin A (retinol), vitamin A
2(retinene) and vitamin A
3(retinoic acid), they all have the compound of natural vitamin A activity.Vitamin A has two kinds, a kind of retinol is initial vitamin A form, only be present in animal food, another kind is beta carotene, it is the precursor of vitamin A, in human body, change retinol into after absorption, it is mainly present in some plant foods, has the physiological action that vitamin A is same.Vitamin A belongs to liposoluble vitamin.
Vitamin A is one group is vision, growth, tissue differentiation and propagation, reproduction and the necessary chemical substance of intact immune system.
Physiological function: 1, participate in power conversion: research shows, when in body during vitamin A insufficiency of intake, just likely affect the eubolism of human body energy, make it superfluous, thus be converted into fat and store in vivo, to produce obesity, a large amount of results of study proves, the energy of China's major part women, children's picked-up in actual life, substantially, reach meal service standard, but trace element is taken in general not enough, can not meet body major physiological demand, so that occur fat.
2, immunity is improved: medical research shows; vitamin A is the necessary material maintaining the normal function of epithelial tissue; epithelial differentiation and the reparations such as respiratory tract can be promoted; ensure the integrality of mucous membrane; thus supporting antiviral invasion, vitamin A also has anti-infectious function, and zincification can help to stop cell entry human body; make respiratory tract from infection, vitamin A and zinc synergy can improve the peanut of vitamin A.Further research shows, serium vitamin A and present positive correlation between periphery T cell percentage and lymphocyte transformation rate.Cell chulture shows, and the generation of vitamin A to lymphocyte antibody of physiological concentration has obvious facilitation.Vitamin A obviously can increase the thymic weight of rat, pulmonary macrophage quantity strengthen its phagocytic function, and makes immune attemperator.
3, maintain mucous membrane, the normal growth of epithelial tissue and differentiation: epithelial tissue throughout the epithelial tissue of whole body, breathing, alimentary canal, urinary system, sexual gland and other body of gland, the participation of the vitamin A that normal differentiation all needs.Vitamin A is to epithelial normal formation, and growth and maintenance have a very important role.Epithelial tissue atrophy, drying, propagation and angling during shortage, cause dry skin, follicular keratosis, trichomadesis, can to cause scheroma to eyes, even blind.
4, normal vision function and control myopia is maintained: the photoreceptor of eyes is rhabdocyte in retina and cone cell, and these two kinds of cells all also exist light sensation pigment, namely feel the rhodopsin of the low light level and photosensitive visual violet.Rhodopsin and visual violet are all be made up of opsin and retinene, and rhodopsin is after illumination is penetrated, and II cis retinene isomery becomes trans-retinene, and are separated with opsin and eclipsed, and this process claims " bleaching ".If enter dark place, then because disappearing to the insensitive rhodopsin of the low light level, therefore thing can not be seen.Vitamin A has and maintains normal visual performance, participates in the metabolism of optic nerve and the formation of interior rhodopsin directly, has important effect to retinal function, to vision protection, prevent and treat myopia and also have certain effect.In addition, vitamin A also can prevent yctalopia, the blurring of image, the various eye illness for the treatment of, promotes the formation of intraocular photopigment.VAD symptom is that dark adaptation ability declines, and severe patient can cause yctalopia, namely cannot see material clearly under half-light.Due to cornea, conjunctival epithelium tissue, the degenerative lesions such as lachrymal gland, cause bitot's patches, a series of pathologies such as inflammation, ulcer, keratinization., there is look shape silver gray spot at conjunctiva, cornea major injury can cause irreversible blind in famine vitamin A.In addition, vitamin A also contributes to the treatment to multiple eye diseases (as xerophthalmia and conjunctivitis) etc.
5, anti-visual fatigue: work before computer for a long time, see TV, the people Chang Hui played games feels eye fatigue, dry and astringent.Scientific research is pointed out, vitamin A can play effective protective effect to eyesight, and adjustable eyes adapt to the ability of extraneous light intensity, to reduce the generation of yctalopia and hypopsia, maintains normal vision response, prevention kopiopia.
In addition, vitamin A also has promotion children bone growth and development, preventing respiratory infection, dispels the effect such as senile plaque expelling, beauty treatment.
(10) vitamin C (Vit C) has another name called ascorbic acid.It is the natural materials be extensively present in fruits and vegetables.Vitamin C is a kind of simple six carbon compounds, and occurring in nature has two kinds of existence forms, and namely reduced form ascorbic acid and oxidized form hydroascorbic acid, both have physiologically active, all can be utilized by body.
Physiological function: 1, participate in biosynthesis, vitamin C participates in multiple important biosynthetic process as the enzyme of substrate and cofactors in digestion process in vivo, comprises collagen, other neurotransmitter of carnitine and peptide hormone synthesis and tyrosine metabolism etc.Some enzyme require vitamin C could keep the activity of height.
2, neuroprotective cell, research finds, the nerve cell in eyes needs the function relying on vitamin C to bring into normal play.American Studies personnel find, the inside and outside needs of retina cell are in the normal function of vitamin C competence exertion of corresponding higher concentration.Due to the part that retina is central nervous system, therefore, vitamin C probably serves beyond thought important function in the brain.
There is a kind of acceptor being called GABA type in brain, its effect makes the high-speed traffic between help adjustment brain cell.Researcher finds, after removing vitamin C, and these acceptors in retina cell, function of just can not bringing into normal play.Due to retina cell and brain cell closely, the GABA acceptor at other positions therefore in brain wants normally to play a role also needs vitamin C.Vitamin C has protective effect to these acceptors and cell.This discovery has important meaning to glaucoma.Because glaucoma is enlivened relevant with the nerve cell transition in retina and brain, reason is that GABA function of receptors occurs abnormal.Therefore, vitamin C produces neuroprotection to retina.
3, bright eyes: the Vitamin C content in eyes is than several times about high in blood, and with advancing age, nutrient absorption metabolic function is faded, Vitamin C content in eyes declines, and in the course of time, easily causes crystalline lens malnutrition, sex change, therefore, vitamin C can become clear eyes.
4, prevent retinal hemorrhage: the body of people lacks vitamin C can make capillary permeability increase, vascular sclerosis, eye is held back the severe edema due to hypofunction of the spleen and is swollen, easily cause that eye is held back, anterior chamber, vitreum, retinal hemorrhage.Vitamin C can reduce capillary permeability, improves eye capillary elasticity.Thus the generation of retinal hemorrhage is prevented.
5, dispelling fatigue: vitamin C participates in the oxidation-reduction process of various nutrition in body, and have a great impact the metabolism of protein, the replenishing vitamins C when heavy physical labour, can improve the endurance of muscle, accelerates antisecosis.
6, immunity, anti-flu is improved: vitamin C can promote prostate and lymph liquid secretion, body is made to produce interferon and antitoxin, thus play immunity and antivirus action, improve the control ability to body tissue, contributing to synthesis can regulate lymphocytic prostaglandin.US Experts research shows, every day, about 1 gram vitamin C can make flu decline 45%, and the course of disease shortens 60%.Vitamin C can be linked up respiratory apparatus and be stimulated circulation, and preventing respiratory infects, and strengthens the oxidation of body requirement, reduces flu and occurs.Vitamin C, except above-mentioned functions, also has the Maintenance Of Skin Health, anti-ageing several functions of waiting for a long time.
(11), zinc (Zn), zinc is one of trace element of wanting of body weight for humans.Mainly be present in the organs such as bone tooth, skin, muscle, especially with retina, choroid, prostate is the highest.Zinc relates to the metabolic each aspect of organism, comprises transcribing and copying of inhereditary material; With health and disease closely related.Zinc be the paving of more than 100 kind of enzyme in human body help because of in, be also the constituent of protein, hormone and nucleotides.
Physiological function: 1, enhancing development; Zinc participates in the synthesis of collagen, nucleic acid and protein; And be all required to each process of the growth of cell and regeneration, division and molecule, therefore, zinc is all very important trace element to being in the vigorous children and adolescents that grows.Height and the learning and memory of Zn content are obvious positive correlation.Zinc is mainly combined on brain cell membrane, can activate phosphopyridoxal pyridoxal phosphate synzyme and suppress γ mono-aminobutyric acid (GABA) synzyme, thus reducing the synthesis of central inhibitory neurotransmitter γ mono-aminobutyric acid.Zinc plays key effect in adjustment neuron γ mono-aminobutyric acid concentration, and particularly human brain hippocampus zinc concentration is the highest, and hippocampus learns the important core group recalled, and therefore, affects the eubolism of hippocampus, thus affect learning and memory after lacking zinc.One university research of the U.S. finds, in the clever children and youth body succeeded in school, zinc content is all high than fathead.
2, immunologic function is improved: the integrality of appropriate zinc supplementation to protection body immune system is very important.Zinc can strengthen macrophages phagocytic capacity, thus plays immunization.Human body lacks zinc, then cause very large impact to the performance of immune cell function.Also can affect central immune organ thymus gland secretion thymosin extrasin and activity simultaneously.Continuation lacks zinc will cause involution of thymus, lymphocytophthisis, and the immune factors such as monocyte cumulative interference element, interleukins and TNF in blood of human body, if zinc insufficiency of intake, the synthesis of these immune factors obviously reduces.
3, control myopia: zinc is the active factors of more than 100 kind of enzyme in human body, and be also that eyesight forms necessary nutriment, the Zn content of eyes is high.Zinc can strengthen optic nerve susceptibility, improves diopter control myopia.If there is no sufficient zinc in body, visual impairment can be caused, blurring of vision under the low light level.Scarce zinc can affect that vitamin A absorbs in vivo, retina can produce obstacle depending on the synthesis of quality, thus affect cone, cell distinguishes look function.Thus also zinc should be supplemented while replenishing vitamins A.Zinc content in the vision optic nerve of people is the highest, and have people to carry out detection to 86 of certain middle school myopia students and find, the content of the zinc in their serum is all lower than the people of twenty-twenty control group.
(12), chromium (Cr), chromium is one of body trace element, and its active component is trivalent chromium, and chromium self can not synthesize in human body, chromium and health closely related, be mainly distributed in bone, skin, fat, adrenal gland, brain and muscle.
Chromium mainly as GTF (GTF) constituent, plays insulin action at human body, promotes that body is to the utilization of glucose.
Physiological function: 1, form GTF, strengthens the effect of insulin: chromium affects glycometabolism by GTF (GTF).GTF synthesizes in liver, and by trivalent chromium and amino acid, the compound that (cysteine, glutamic acid, glycine etc.) are formed participates in forming.Chromium is that insulin is required in human body performance best-of-breed functionality institute, and chromium also can promote that sugar turns to glycogen at transit cell.Tissue is to insulin sensitivity reduction to lack chromium, and chromium, as a confactor of insulin, can strengthen the stability of insulin function, keeps insulin level in blood.By insulin and reacting cells set on acceptor, promote the effect of insulin or improve the sensitiveness of tissue to insulin.
2, regulate glycolipid metabolism: it is reported, zoopery finds, chromium deficiency can cause fat metabolism element disorderly, and serum cholesterol raises and the rising of artery blood fat, causes atherosclerotic plaque to be formed, if award enough chromium agent can improve lipodogramme in blood.Reduce the effect of T-CHOL and low-density lipoprotein in blood.Separately have report, chromium is the indispensable auxiliary element of insulin, can play a role by assist insulin, promote that body makes carbohydrate, lipometabolicly normally to carry out, promote fat (unrighted acid) and protein synthesis, growth in humans's growth is played an important role.Medical research shows) glucose-lipid metabolism disorder such as diabetes, hypertension, coronary heart disease, atherosclerotic is relevant with scarce chromium, and American science family expenses trivalent chromium is treated many above-mentioned diseases, and they obviously reduce by blood cholesterol level.
3, develop immunitypty, it was reported that to domestic animal injection chromium, but serum immune globulin increases, impact is had on specific immune function, also there is research prompting, to being in stress situation livestock supplementary chromium in feed, immunity being improved, therefore confirming that chromium is on immunoreactive impact.
4, control myopia: chromium participates in the metabolism of glucose, can strengthen the activity of insulin.Chromium deficiency will make insulin regulate the function of sugar to be had a strong impact on, and plasma osmolarity raises, and impel eye lens to become convex, aqueous humor osmotic pressure and diopter increase, thus cause myopia.It is reported, American scientist is pointed out after analyzing thousands of adolescent myopia cases, chromium and myopia in close relations, human body lacks chromium will cause myopia.This is because the sugar in human body plays an important role with fat chromium energy assist insulin in metabolism.When human body lacks chromium, the effect of insulin will obviously reduce, thus makes body not effectively utilize sugar, there will be moderate hyperglycemia, diabetes and angiosis sex change phenomenon during serious scarce chromium.These pathologies have a certain impact to eyesight, and particularly blood sugar is high, easily cause colloidal osmotic pressure, and making crystalline lens become convex, diopter increases, thus causes myopia.
(13), selenium (Se), selenium is micro elements needed by human., the institute distributed in vivo in addition to fats in a organized way in, being the highest in liver, kidney, the heart, spleen and nail., in blood of human body, selenium concentration differs, and it is by soil in living environment, the impact of water and Selenium In Foods content.Selenium has several functions in human body, or the required composition of glutathione peroxidase.
Physiological function: 1, anti-oxidant: the antioxidation of selenium can the integrality of Cell protection film, scavenging free radicals is anti-ageing.Owing to containing unrighted acid in human body cell film, in the tissue more containing oxygen, easily there is oxidation reaction, generate lipid peroxide.And lipid peroxide is put aside in human body, can cause physiological function decline liver, lung and cardiovascular damage, also can accelerate human senility speed simultaneously, the appearance as senile plaque expelling is exactly the result of epidermal tissue's accumulation lipid peroxide.Selenium, as the constituent of glutathione peroxidase, has the effect of decomposing MDA in vivo, thus protection biological cell membrane is from damage, safeguards the normal function of cell, and protection body is from Oxidative demage.
2, immunologic function is strengthened: selenium has immunity moderation function, almost exists in all immunocytes, and to nospecific immunity, humoral immunity and cellular immunity have a direct impact.Can urge the generation of interferon, increase its activity, increase the antivirus action of body NK cell, selenium can also impel lymphocyte to produce antibody, increases the secretion of immunoglobulin (Ig), and enhancing body produces the ability of antibody to immune or other antigen; Selenium also can strengthen lymphocyte transformation and delayed allergy, promotes phagocytic function, increases the antigenic capacity of leukocytes phagocytic and sterilizing ability and spleen mucosa cells, thus shields to immune system.In addition, selenium also has antibacterial, antiviral effect of Denging.
3, control myopia: selenium is present in human multiple tissue cell, especially the highest with eyes selenium content is a kind of important trace element maintaining eyesight.Research is thought, lenticular oxidative damage is the major reason that retina and myopia are formed.And selenium is the active material of antioxidase in crystalline lens, crystalline lens and retina oxidative damage can be reduced, and can eyesight be improved.Scarce selenium can cause myopia, because selenium has certain protective effect to retina, and can regulate the absorption of vitamin A and consumption, in organism metabolism process, play vital effect.Therefore, retinopathy, myopia and visual impairment etc. can be caused when selenium deficiency.In addition, selenium can also prevent and treat cataract.
In sum: this product tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity, the effect such as strengthening spleen and nourishing stomach, beneficial blood.There is control myopia, pseudomyopia, vision disorder, treatment nutritional amblyopia, anti-eye strain, prevent pseudomyopia to true myopia progression, prevent and treat glaucoma, prevent the injury, immunity moderation power etc. of diabetes to eyesight from having special effect.
Six, manufacture craft
1, raw material mixing: the raw material in formula is mixed by physical characteristic.
2, stir: mixed raw material is sent into mixer and stirs.
3, compressing tablet: the raw material stirred is sent into tablet press machine, makes raw material be pressed into tablet.
4, test package: be up to the standards, packaging becomes formal product.
Raw material mixed processes is by the process of raw material mixing all in component design.Raw material agitating procedure is the process stirred by mixed raw material.Sheeting process is the process raw material stirred being pressed into tablet, and test package is the tablet that will be pressed into, and is up to the standards, and packaging becomes the process of formal product.
Seven, quality standard:
1, physical and chemical index:
| Black matrimony vine extract | g/100g | 14.29 |
| Longan extract | g/100g | 11.91 |
| Mulberry extract | g/100g | 16.67 |
| Semen sesami nigrum extract | g/100g | 14.29 |
| Dried orange peel extract | g/100g | 10.48 |
| Alpha-linolenic acid | g/100g | 0.48 |
| Lutein | g/100g | 13.33 |
| Beta carotene | g/100g | 0.048 |
| Vitamin A | g/100g | 0.024 |
| Vitamin E | g/100g | 0.38 |
| Vitamin C | g/100g | 4.76 |
| Zinc | 0.57 | |
| Chromium | mg/100g | 7.14 |
| Selenium | mg/100g | 4.80 |
2, adaptation population: be adapted to staff before children and youth and all asthenopia persons and computer.
3, instructions of taking: every day 3 times, each serving consumption 0.5-0.7 gram
Embodiment: get black matrimony vine extract 10-70 kilogram, longan extract 10-50 kilogram, mulberry extract 10-40 kilogram, Semen sesami nigrum extract 10-80 kilogram, dried orange peel extract 10-60 kilogram, alpha-linolenic acid 10-50 kilogram, lutein 0.1-0.6 kilogram, beta carotene 10-15 gram, retinol1 0-60 gram, vitamin E 0.2-0.8 kilogram, vitamin C 10-40 kilogram, zinc 0.12-0.6 kilogram, chromium 12-30 milligram, selenium 10-60 milligram, auxiliary material is that raw material mixing stirs, send into tablet agent and raw material is pressed into tablet, be up to the standards, packaging becomes formal product.
Claims (1)
1. black matrimony vine is protected and looks bright eye lozenge manufacture craft, it is characterized by: black matrimony vine extract 10-70 kilogram, longan extract 10-50 kilogram, mulberry extract 10-40 kilogram, Semen sesami nigrum extract 10-80 kilogram, dried orange peel extract 10-60 kilogram, alpha-linolenic acid 10-50 kilogram, lutein 0.1-0.6 kilogram, beta carotene 10-15 gram, retinol1 0-60 gram, vitamin E 0.2-0.8 kilogram, vitamin C 10-40 kilogram, zinc 0.12-0.6 kilogram, chromium 12-30 milligram, selenium 10-60 milligram, auxiliary material is raw material, through above raw material is mixed, stir, send into tablet press machine, raw material is pressed into tablet, be up to the standards, packaging becomes formal product.
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| CN104938753A (en) * | 2015-06-09 | 2015-09-30 | 广东庭颢药业股份有限公司 | Mulberry-containing tablet candy for improving eyesight |
| CN105231447A (en) * | 2015-10-28 | 2016-01-13 | 青海尤尼克生物技术有限公司 | Health-care lycium ruthenicum tablets capable of alleviating asthenopia |
| CN106722987A (en) * | 2016-12-12 | 2017-05-31 | 宁夏沃福百瑞枸杞产业股份有限公司 | A kind of preparation method of lycium ruthenicum lozenge |
| CN110226751A (en) * | 2019-07-10 | 2019-09-13 | 完美（广东）日用品有限公司 | A kind of composition with eye protection effect |
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| WO2022140253A1 (en) * | 2020-12-22 | 2022-06-30 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Cellular health nutritional product |
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| CN104938753A (en) * | 2015-06-09 | 2015-09-30 | 广东庭颢药业股份有限公司 | Mulberry-containing tablet candy for improving eyesight |
| CN105231447A (en) * | 2015-10-28 | 2016-01-13 | 青海尤尼克生物技术有限公司 | Health-care lycium ruthenicum tablets capable of alleviating asthenopia |
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| CN110226751A (en) * | 2019-07-10 | 2019-09-13 | 完美（广东）日用品有限公司 | A kind of composition with eye protection effect |
| WO2022140253A1 (en) * | 2020-12-22 | 2022-06-30 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Cellular health nutritional product |
| CN113558084A (en) * | 2021-07-23 | 2021-10-29 | 张建忠 | Medicinal and edible food therapy composition for preventing and treating eye diseases |
| CN116059287A (en) * | 2022-12-29 | 2023-05-05 | 广州千物百草生物科技有限公司 | Plant fermentation liquid for regulating endocrine dyscrasia and maintaining uterus, and preparation method and application thereof |
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