CN104940273A - Vision improvement healthcare product and preparation method thereof - Google Patents
Vision improvement healthcare product and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of healthcare products, in particular to a vision improvement healthcare product and a preparation method thereof. The healthcare product mainly comprises, by weight, 20-40 parts of xanthophylls, 40-60 parts of taurine, 5-10 parts of black currants and 5-10 parts of blueberries. The healthcare product can relieve visual fatigue, improve visuognosis persistence of the eyes and well improve the symptoms of blurred vision, eye dryness, eye distension, ophthalmodynia and photaesthesia. The preparation method is simple, efficient, high in raw material utilization rate and suitable for industrial production.
Description
Technical field
The present invention relates to health product technology field, be specifically related to a kind of health product improving vision and preparation method thereof.
Background technology
In today of digital age, we seem cannot break away from hands machine, computer, dull and stereotyped, people almost cannot leave mobile phone and computer, long-time to the machine of setting about, it is the habitual thing of modern, mobile phone control, computer office control phenomenon is more and more general, working is long-time facing to computer office, on the way home facing to mobile phone or flat board, mobile phone brush screen is had in arms before sleeping, still mobile phone brush screen is had in arms after waking up, especially youngster mobile phone is not from hands, like seeing novel with mobile phone, play games, upper microblogging, but these electronic products seeming very damp can allow your eyes from health more and more away from, increasing people is by " digital visual fatigue (DEF) " invasion and attack, such as eye is dry and astringent, tired, and even eye distending pain, visual deterioration etc.
Concrete, play mobile phone for a long time, see computer, following a few class eye problems can be caused:
1, to play games the xerophthalmia that is easy to get
When playing games, on screen, the shadow of constantly flicker can cause lasting stimulation to eyes, when eyes ceaselessly catch these shadows, eyes will be made to feel tired especially.Attention is too concentrated, and natural number of winks greatly reduces, and causes damage to the tear rete of eyeball surface, thus the fatigue of exacerbate eye and the sensation such as dry and astringent, scratchy, even occurs eyes stung, sheds tears, the malaise symptoms such as photophobia, and xerophthalmia occurs.
2, easily asthenopia is caused
Long-time eye inherently easily causes asthenopia, and when staring at mobile phone screen with breathless interest, on screen, the shadow of constantly conversion can cause lasting stimulation to eyes again, when eyes ceaselessly catch these shadows, eyes will be made tired especially.Especially when surrounding is dark, and when mobile phone screen is bright, especially large to the infringement of eye, if things go on like this will cause visual deterioration, the problems such as myopia degree intensification.
3, object for appreciation mobile phone of bowing easily suffers from conjunctivitis
Long-time object for appreciation mobile phone, particularly bows and sees the mobile phone, can damage the conjunctiva of eyes on the car jolted.Because keep the posture of fixedly bowing for a long time, easily making blood flow to eyes, cause conjunctiva blood vessel mild hyperaemia, also easily there is slight nipple hypertrophy and forms folliculus etc. in palpebral conjunctiva.Originally, may have corner of the eyes portion (canthus) erubescence, moistening, incrustation phenomenon, if do not noted, then can bring out the chronic inflammatory processes of conjunctival tissue, cause chronic conjunctivitis.
4, cause eyes dry and astringent, scratchy
The general screen of smart mobile phone is large, brightness is high, screen is concentrated too many information, when staring at screen with breathless interest, on screen, the shadow of constantly conversion can cause lasting stimulation to eyes, when eyes ceaselessly catch these shadows, will to cause damage to the tear rete of eyeball surface, thus the fatigue of exacerbate eye, the sensation such as dry and astringent, scratchy, even to make eyes have twinge, shed tears, the symptom such as photophobia occurs.
5, adolescent myopia is caused
When being absorbed in mobile phone games, because the word on mobile phone and picture are all less, eyes can unawares from mobile phone screen more and more close to, if things go on like this, be easy to bring out myopia, particularly under-18s is in the teenager of growth and development stage, closely uses mobile phone, and the heat effect that screen produces also can threaten to the health of eyes.
In addition, in the face of the student of heavy schoolwork burden, with the unhealthy appearance that also can cause the visual problems such as eyestrain of eye custom, current visual problems has become the No.1 obstacle of middle and primary schools' health.Modern medicine study shows, the generation of vitamin and ophthalmic, the quality of vision have very close relationship.With the too much person of eye, need the vitamin needed for more eyes and mineral.Nutrient needed for reasonable supplement eyes, to protection eyes, prevent vision injure, prevent and treat ophthalmic, improve vision extremely important.Although also there are some in the market can the nutriment of the visual problems such as alleviating asthenopia, it is comprehensive that it improves effect, can not solve eye problems, therefore DeGrain comprehensively.How can alleviate visual problems better, more fully improve vision health is the problem that the application is devoted to solve.
Summary of the invention
The object of this invention is to provide a kind of health product improving vision, these health product can alleviating asthenopia, improves binocular duration of photopic vision, and the symptoms such as, ophthalmic bloated, ophthalmalgia, photophobia dry and astringent for blurred vision, eye have good improvement result.
The present invention also aims to provide a kind of preparation method improving the health product of vision, this preparation method is simple, efficient, and raw material availability is high, is suitable for suitability for industrialized production.
In order to realize above object, the present invention adopts following technical scheme:
Improve health product for vision, the raw material primarily of following weight portion is made:
Phylloxanthin 20 ~ 40 parts, taurine 40 ~ 60 parts, black currant 5 ~ 10 parts, blue berry 5-10 part.
Also comprise following raw material: sucrose, dextrin, citric acid, grape essence, magnesium stearate.
Described health product are made up of the raw material of following parts by weight: phylloxanthin 20 ~ 40 parts, taurine 40 ~ 60 parts, black currant 5 ~ 10 parts, blue berry 5-10 part, sucrose 300-450 part, dextrin 200-350 part, citric acid 1-5 part, grape essence 1-5 part, magnesium stearate 1-5 part.
Described health product are made up of following raw material by weight: phylloxanthin 28 parts, taurine 52 parts, black currant 8 parts, blue berry 7 parts, sucrose 380 parts, 270 parts, dextrin, citric acid 3 parts, grape essence 2 parts, magnesium stearate 3 parts.
The preparation method of the health product of above-mentioned improvement vision, comprises the following steps:
(1) pulverize: phylloxanthin, taurine, black currant, blue berry, sucrose, dextrin, citric acid, magnesium stearate are pulverized respectively;
(2) batch mixing: each raw material after step (1) being pulverized mixes, and is specially: phylloxanthin and taurine mixing by weight, obtains mixed powder A; Mixed powder A is mixed with sucrose, obtains mixed powder B; By blue berry and dextrin mixing, obtain mixed powder C; Black currant is mixed with citric acid, obtains mixed powder D; Mixed powder C is mixed with mixed powder D, obtains mixed powder E; Mixed powder B is mixed with mixed powder E, obtains total mixed powder;
(3) soft material processed: mixed with ethanol by total mixed powder, obtains mixing soft material;
(4) granulate: soft material is crossed 14 mesh sieves and granulate, obtain wet granular;
(5) dry: wet granular to be carried out drying, obtains dry granule;
(6) batch mixing tabletting: be dissolved in by grape essence in ethanol, sprays on dry granule, obtains always mixed granule; To always mix granule to mix homogeneously with magnesium stearate, obtain always mixed thing; Carrying out tabletting by always mixing thing, obtaining finished product.
In step (1), sucrose is first pulverized after 80 mesh sieves, and phylloxanthin, taurine, blue berry, black currant, dextrin, citric acid cross 80 mesh sieves respectively, and magnesium stearate crosses 100 mesh sieves, obtains each raw material fine powder.
In step (5), baking temperature is 50-60 DEG C.
Ethanol described in step (3) is mass fraction 75% ethanol, and ethanol consumption is the 20-30% of mixed powder weight.
Ethanol described in step (6) is mass fraction 95% ethanol, and ethanol consumption is and glucose essence equivalent.
Phylloxanthin, has another name called plant progesterone, is extensively to be present in the natural pigment in the plants such as flowers, fruit, vegetable.Phylloxanthin belongs to carotenoid, and have two ionone rings and the carbochain containing multiple conjugation unsaturated double-bond, the molecular formula of phylloxanthin is C40H56O2, and molecular weight is 568.85.Large quantity research shows, phylloxanthin is not only relevant with macula retinae density, simultaneously also closely related with the normal visual function of maintenance.Many Epidemiological study result displays, there is positive correlation in phylloxanthin intake and macula retinae pigment density.The damage that the increase of macula retinae pigment density can prevent light exposure on human visual function from causing, prompting phylloxanthin may have the amphiblestroid effect of protection.Bhosale etc. compare the macula retinae district that 147 are contributed people, find to carry out the supplementary people of phylloxanthin before death, and its macula retinae pigment density is significantly higher than matched group.Hammond etc. find the people that retina phylloxanthin concentration is high, and corresponding photopic vision, scotopia and the sensitivity level to short wavelength light are significantly higher than the low people of retina phylloxanthin concentration.Thomson etc. have carried out animal experiment study, feed Carnis Coturnicis japonicae with phylloxanthin, find the phylloxanthin photoperiod sensitivity gene that caused by photic damage of enrichment can suppressing on the retina.Muriach etc. are after giving in mouse feed and adding phylloxanthin, by measuring the content of Mouse Retina oxidation metabolites malonaldehyde (MDA), glutathion peroxidase (GPX) and NF-κappa B (NFKB), find that phylloxanthin can reduce amphiblestroid oxidative damage.
Phylloxanthin, as carotenoid important in retina, all plays very important effect in the amphiblestroid normal function of maintenance and protection retina oxidative damage.Phylloxanthin can reduce blue light strength and effectively reduce amphiblestroid oxidative damage.Blue light allly can reach a kind of light that in amphiblestroid visible ray, energy is the highest, potential hazard is maximum, can cause retinal pigment epithelium and photoreceptor cell，photosensory cell damage; And under Induced by Blue Light, pigment epithelium constantly produces metabolite---lipofuscin and A2E, can produce by induced activity oxygen, cause lipid peroxidation directly or indirectly, thus cause retinal epithelial cells apoptosis.The maximum absorption wavelength of phylloxanthin is just in the wave-length coverage of blue light, in eyes retina, form blue light filter, reduces the probability that blue light arrives photoreceptor and retinal neuronal cell.Phylloxanthin molecule contains conjugated double bond, easily loses electronics, blocks radical chain transmission, thus has antioxidation; In addition, phylloxanthin with the contaminated with lipid on cell membrane, can suppress the oxidation reaction of lipid effectively, alleviates oxidation product to amphiblestroid infringement, plays the effect of alleviating asthenopia.
Blue berry, a kind of small berries, fruit is in blue, and color and luster is beautiful, blue to be wrapped up by 1 layer of white fruit powder, and sarcocarp is fine and smooth, seed is minimum.Blueberry on average weighs 0.5 ~ 2.5g, maximum heavy 5g, and edible rate is 100%, sweet and sour palatability, and has fragrant refreshing pleasant fragrance, for eating good merchantable brand raw.Substantially there is distribution in the whole world, mainly be distributed in the cool sunny area of weather temperature, China is mainly in Liaoning, Heilungkiang, the areas such as Jilin, Changbai Mountain northeastward and the wild varieties resource of Xing'anling mountains one with blue berry class plants such as the many wild Vaccinium uliginosum of self-sow (being commonly called as Vaccinium uliginosuml, all Fructus Kaki), Pericarpium Citri tangerinaes.
Anthocyanidin is a kind of very important plant water-soluble pigment, belongs to the anti-aging and nutritive supplement of pure natural, is the most effective antioxidation biology activating agent that the current mankind find.In blue berry, anthocyanidin content is very high, and anthocyanidin kind is also very abundant simultaneously, and research finds to contain Anthocyanins in high clump blue berry unexpectedly up to 15 kinds more than, although the content of anthocyanidin is not identical in different cultivars blue berry, general content is all relatively high.And anthocyanidin can protect eyes, relieving eye strain, improve the vision of people, blue berry is not only containing vitamin A, and its main component is anthocyanidin, directly can accelerate retina, the synthesis of rhodopsin and regeneration, allows eyes burst forth vigor brilliance.The biomedical doctor Zhong Chuan of Japan and grandly to write articles: clinical medicine report display, the anthocyanidin in blue berry can promote that the rhodopsin in retina cell regenerate, pre-myopia prevention, enhancement vision.Also be rich in the nutritional labelings such as abundant vitamin, mineral and fiber element in blue berry, the more edible blue berry can improve body immunity, improves human quality simultaneously.
Blue berry owing to being rich in anthocyanidin, there is activation retina effect, vision can be strengthened, prevent eyeball tired and enjoy and gaze at, one of five large healthy fruit that Ye Shi the World Food Programme is recommended.And according to the U.S., Japan, European Section scholar research, often edible blue berry goods, also can vision enhancing significantly, anti-eye strain.
Taurine, body can absorb or self synthesizing taurine from meals, and animal food is the main source of meals taurine, especially marine animal.In body, synthesis is transformed from sulfur-containing amino acid (cysteine, methionine etc.) through a series of enzymatic reaction, but self synthesis capability is lower.The molecular weight (125.1) of taurine, no antigen, various administration all easily absorbs.Taurine is mainly from renal excretion, and kidney regulates its output according to content of taurine in meals, to maintain the relatively stable of content of taurine in body.Taurine accounts for 50% of retina Free Amino Acids total amount, and zoopery proves, lacks its electroretinogram display pole cell of cat of taurine and the extensive degeneration of cone cell.After the concentration of growing fetal development mesencephalic tissue is significantly higher than birth, prompting taurine to development of central nervous system, as cell propagation, dividing a word with a hyphen at the end of a line has effect with differentiation.
Taurine also has raising nerve conduction and visual function: why cat and night flight or navigation owl will prey on mouse, and its main cause is that polyphagia can keep its sharp keen vision containing abundant taurine in mouse body.If infant lacks taurine, retinal function disorder can be there is.The patient of long-term parenteral nutrition, if do not have taurine in transfusion, can make patient's retina map of current change, and only has the taurine supplementing heavy dose could correct this change.
Black currant, formal name used at school black currant (Ribes nigrum L.), has another name called Ribes nigrum L., black bean fruit, purple prunus mume (sieb.) sieb.et zucc., and Saxifragales Grossulariaceae currant belongs to, and small shrub, its mature fruit is black small berries, is inside rich in vitamin C, anthocyanidin, edible.Also fruit juice can be processed into, the food such as fruit jam.Black currant contains very abundant vitamin C, phosphorus, magnesium, potassium, calcium, anthocyanidin, aldehydes matter.The health-care effect of the black currant known at present comprises prevention gout, anemia, edema, arthritis, rheumatism, oral cavity and laryngopharyngeal diseases, cough, the kidney invigorating etc.The middle and high dosage group TG of black currant, TC, LDL-C are starkly lower than hyperlipidemia model group, and HDL-C is apparently higher than hyperlipidemia model group (P<0.01), and as can be seen here, black currant has the effect reducing Experimental Hyperlipemia lipid of mice.
The eyeball of human body is the organ accepting photostimulation, in environment, some light can cause damage to eye retina, this process is called " rat retina during photochemical damage ", the absorption induced retinal of excess photon noise produces a large amount of free radicals, lipid peroxidation and active oxygen is caused to be formed, impel retinal photoreceptor cells dysfunction, finally cause visual function impaired.Black currant is rich in multiple antioxidation biology active substance, as anthocyanidin, vitamin C, flavone and phenolic acid etc., and can by for human body supplements antioxidant and protect visual function.
Sucrose, uses as filler, sweeting agent, and has the effect of bonding; Dextrin: dextrin is amylolytic intermediate product, can be used as filler and uses; Citric acid: be acidity regulator, uses as correctives, regulates the mouthfeel of goods of the present invention.Grape essence: be edible essence, uses as correctives, regulates mouthfeel.Magnesium stearate: use as lubricant.
The present invention adopts phylloxanthin, taurine, black currant, blue berry to be that main effective ingredient prepares the health product improving vision, wherein, phylloxanthin can improve macula retinae pigment density, thus avoids light exposure on human visual function to cause damage, protection retina; And taurine is requisite material in visual acuity process, if lack taurine in visual acuity process, then retinal function disorder can be there is.Though human body self can synthesize a part of taurine, its synthetic quantity is few, and main or dependence is absorbed from meals.Taurine, phylloxanthin cooperatively interact by the present invention, and the former plays the good effect promoting visual acuity in visual acuity process, and the latter is protecting retina with in eye process by improving macula retinae pigment at ordinary times.And in blue berry, be rich in anthocyanidin; retina, the synthesis of rhodopsin and regeneration can be accelerated, thus relieving eye strain, improve human body vision, except containing except anthocyanidin in black currant; also containing vitamin C, flavone and phenolic acid, the vision protection function by supplemental oxidant.In above-mentioned 4, primary raw material not only carries out general protection from aspects such as amphiblestroid growth, protection, regeneration to retina; thus vision protection; simultaneously also by materials such as anthocyanidin wherein to alleviating with the asthenopia in eye process at ordinary times, thus improve human body vision.Sucrose is as sweeting agent, and improve the mouthfeel of the bitterness of chewable tablet of the present invention, difficult pharynx well, for these health product increase sweet taste, grape essence and citric acid then inject abundanter mouthfeel for these health product, make health product sweet mouthfeel of the present invention, delicate fragrance.
Detailed description of the invention
Embodiment 1
Improve health product for vision, described health product are made up of following raw material by weight: phylloxanthin 28 parts, taurine 52 parts, black currant 8 parts, blue berry 7 parts, sucrose 380 parts, 270 parts, dextrin, citric acid 3 parts, grape essence 2 parts, magnesium stearate 3 parts.
The preparation method of the health product of above-mentioned improvement vision, comprises the following steps:
(1) pulverize: phylloxanthin, taurine, black currant, blue berry, sucrose, dextrin, citric acid, magnesium stearate are pulverized respectively;
(2) batch mixing: each raw material after step (1) being pulverized mixes, and is specially: phylloxanthin and taurine mixing by weight, obtains mixed powder A; Mixed powder A is mixed with sucrose, obtains mixed powder B; By blue berry and dextrin mixing, obtain mixed powder C; Black currant is mixed with citric acid, obtains mixed powder D; Mixed powder C is mixed with mixed powder D, obtains mixed powder E; Mixed powder B is mixed with mixed powder E, obtains total mixed powder;
(3) soft material processed: total mixed powder is mixed with mass fraction 75% ethanol, obtains mixing soft material, ethanol consumption is 25% of mixed powder weight;
(4) granulate: soft material is crossed 14 mesh sieves and granulate, obtain wet granular;
(5) dry: wet granular is carried out drying, obtains dry granule, baking temperature is 55 DEG C;
(6) batch mixing tabletting: be dissolved in by grape essence in mass fraction 95% ethanol of equivalent, spray on dry granule, obtains always mixed granule; To always mix granule to mix homogeneously with magnesium stearate, obtain always mixed thing; Carrying out tabletting by always mixing thing tablet machine, obtaining finished product.
(7) packaging warehouse-in: inner packing adopts standard No. YBB00122002 oral stable medicinal polythene bottle with high density, 60 every bottle, and outer package adopts corrugated case, then tests according to company standard, puts in storage after inspection.
Whole production process is from pulverizing and sieving to inner packing production environment air purity 300,000 grades.
In step (1), sucrose is first pulverized after 80 mesh sieves, and phylloxanthin, taurine, blue berry, black currant, dextrin, citric acid cross 80 mesh sieves respectively, and magnesium stearate crosses 100 mesh sieves, obtains each raw material fine powder.
Embodiment 2
Improve health product for vision, described health product are made up of following raw material by weight: phylloxanthin 20 parts, taurine 48 parts, black currant 10 parts, blue berry 5 parts, sucrose 360 parts, 320 parts, dextrin, citric acid 1 part, grape essence 4 parts, magnesium stearate 2 parts.
The above-mentioned preparation method improving the health product of vision, in step (3), ethanol consumption is 20% of mixed powder weight, and step (5) baking temperature is 60 DEG C, and all the other are with embodiment 1.
Embodiment 3
Improve health product for vision, described health product are made up of following raw material by weight: phylloxanthin 40 parts, taurine 60 parts, black currant 6 parts, blue berry 8 parts, sucrose 300 parts, 200 parts, dextrin, citric acid 5 parts, grape essence 1 part, magnesium stearate 5 parts.
The above-mentioned preparation method improving the health product of vision, in step (3), ethanol consumption is 30% of mixed powder weight, and step (5) baking temperature is 50 DEG C, and all the other are with embodiment 1.
Embodiment 4
Improve health product for vision, described health product are made up of following raw material by weight: phylloxanthin 36 parts, taurine 40 parts, black currant 5 parts, blue berry 10 parts, sucrose 450 parts, 350 parts, dextrin, citric acid 2 parts, grape essence 5 parts, magnesium stearate 1 part.
The above-mentioned preparation method improving the health product of vision, in step (3), ethanol consumption is 24% of mixed powder weight, and step (5) baking temperature is 58 DEG C, and all the other are with embodiment 1.
Vision protecting foodstuff is improved to gained of the present invention below and carry out safety toxicology experiment
1, acute toxicity testing:
Experimental technique: SD rat (body weight 180g ~ 220g) 20, male and female half and half.If 15g/kg.bw dosage group, accurately takes tested material 75g, is formulated into 200ml with distilled water, by 2ml/100g.bw twice per os gavage, interval time is 4 hours, observes dead animal number and general health situation after two weeks, judge tested material acute toxicity according to maximum tolerated dose after gavage.The health product that described tested material provides for embodiment 1.
Experimental result
Table 1. the acute toxicity tests
| Sex | Number of animals only | Dosage g/kg.bw | Dead animal number/only | MTD(g/kg.bw) | Conclusion |
| Male | 10 | 15 | 0 | ＞15 | Nontoxic |
| Female | 10 | 15 | 0 | ＞15 | Nontoxic |
After the contamination of sample 15g/kg.bw dosage per os, have no animal dead in two weeks, also without obvious poisoning symptom or untoward reaction, the results are shown in Table 1.Cut open after off-test in two weeks and kill all animals, internal organs show no obvious abnormalities change.Namely this inspection product are greater than 15g/kg.bw to acute oral MTD that is female, male SD rat, belong to non-toxic type.Its experimental result of the health product that other embodiments of the invention provide is identical with embodiment 1.
2, rat 30 days feeding trials
After ablactation SD rat adaptability feeds 1 week, be divided into four groups at random by body weight, often organize 20, male and female half and half.A negative control group (distilled water) and three tested material dosage groups are established in test: 1.5g, 3.5g and 5.0g/kg.bw (are equivalent to 30,70 and 100 times of human body recommended intake.Compound method: take 15g, 35g and 50g sample respectively, each adding distil water is to 100ml).The health product that tested material provides for embodiment 1.Animal presses 1ml/100g.bw gavage once every day, continuous 30 days.Claim weekly the weight of animals, twice to appetite and surplus appetite, and calculate food ration.Calculate all food utilizations (%) by Zhou Zengchong and all food rations respectively, calculate total foodstuff utilization rate (%) simultaneously.Put to death animal after 30 days, carry out hematology, Serum bichemisbry and histopathology and organ coefficient mensuration.
Negative control group and 3 dosage treated animals, during 30 days feed, are ingested, are drunk water, defecation is normal, growth promoter situation and general performance good, do not observe evident act and change and poisoning manifestations.
2.1 impacts on body weight:
Each test group the results are shown in Table 2 in the body weight of whole duration of test.The each all body weight of the health product that embodiment 1 provides each dosage treated animal and gross weight Analysis of variance compare there was no significant difference (P > 0.05) with negative control group, show that tested material is grown body growth and have no adverse effects.
Table 2 sample is on the impact of rat body weight
2.2 latter stage blood test result:
Table 3 shows Conventional blood index (erythrocyte, hemoglobin, the platelet) measurement result in experiment latter stage.Difference (P > 0.05) that hematology's testing index of health product each dosage group male and female Mus that embodiment 1 provides as seen from the table compares with negative control group that there are no significant.
Table 3. sample is on the impact of rat blood index
Note: RBC is erythrocyte, and Hb is hemoglobin, and WBC is leukocyte, and GR is neutrophilic granulocyte, and LY is lymphocyte.
Brief summary: the acute oral MTD of sample to SD rat is greater than 15g/kg.bw, belongs to non-toxic type.Be in rat 30 days feeding trials of human body recommended intake 100 times (5.0g/kg.bw) at maximum dose level, do not cause the ANOMALOUS VARIATIONS of rat holistic health, biochemical functions and each important indicator of organ-tissue morphology, preresearch estimates maximum no-effect dose is greater than 5.0g/kg.bw.The health product that other embodiments of the invention provide are identical with embodiment 1 performance.
Human feeding trial is carried out to the health product that the embodiment of the present invention obtains below
Tested crowd: select the age to be 18 ~ 65 years old by the principle of voluntariness, vision fatiguability person.
Subject Exclusion Criteria: suffer from infectivity, traumatic eye part disease person; Suffers from the inside and outside eye disease patient such as cornea, crystal, vitreous body, retinopathy; Suffer from the disease patients such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system; Take the article relevant with tested function in a short time, have influence on the judgement person to result; Other associated therapy medicines of long-term taking, health product or use other Therapeutic Method to fail terminator; Do not meet inclusive criteria, edible by regulation, or data is not congruent affects effect or safety judgement person.
Experimental design and grouping: 120 routine experimenters are divided into test group and placebo group at random, test group medicine used is the health product that the embodiment of the present invention 1 obtains, placebo group medicine used is not containing the starch tablets of effective ingredient, often organize 60 people, the factors such as age, sex, vision have comparability, and result of the test adopts and contrasts between self cross-reference and group.
Result:
1, experimenter 120 example is observed altogether, effective case 100 example.Test group male 14 example, women 36 example; 27 ~ 65 years old age, 51.40 years old mean age; Photopic vision shortest time 57 seconds, the longest 124 seconds,
Average course of disease 2.80.Matched group male 14 example, women 36 example; 23 ~ 65 years old age, average 50.12 years old; Photopic vision shortest time 40 seconds, the longest 127 seconds, average course of disease 3.25.Before observing, situation compares in table 1.
Table 4. is tested front physical data and is compared
Before two groups of test-meals, indices no significant difference (P > 0.05), has comparability.
2, the change of heart rate before and after test-meal
Table 5. test before and after heart rate (secondary, point), blood pressure (mmHg) change
3, vision effect is improved:
The comparison of distant vision change before and after table 6. liang group test-meal
Own control * * P < 0.01***P < 0.001 before and after test-meal
4, duration of photopic vision change is compared
The comparison of duration of photopic vision change before and after table 7. liang group test-meal
unit %
| Grouping | Before test-meal (n=50) | After test-meal (n=50) | Improvement value |
| Test group | 55.50±8.07 | 71.06±11.90*** | 15.56### |
| Matched group | 56.28±8.89 | 58.57±8.08* | 2.29 |
Test-meal before and after test group own control * * * P < 0.001; Matched group own control * P < 0.05; After test-meal, test group compares ###P < 0.001 with matched group
5, cardinal symptom improves situation
Table 8. cardinal symptom improves situation
In each cardinal symptom improvement, test group is all better than matched group.
6, duration of photopic vision effect compares
Before and after table 9. test-meal, duration of photopic vision effect compares
##P < 0.01 is compared between group after test-meal
7, symptom integral statistics
Table 10. clinical symptoms integration is added up
Self compare * * * P < 0.001 before and after test-meal, between group, compare ###P < 0.001
By above table, can draw to draw a conclusion:
1, the health product that the embodiment of the present invention 1 provides have the health care of alleviating asthenopia, and test group eyes duration of photopic vision on average improves 15.56%, and total effective rate is 62.00%; Symptom integral reduces 3.16 ± 1.40, and matched group duration of photopic vision on average improves 2.29%, total effective rate 24.00%, and symptom integral reduces 1.74 ± 1.45, self compares and has significance through statistical procedures difference with comparing between group.Sample has the health care of alleviating asthenopia.
2, compare with matched group, sample obtains the symptoms such as blurred vision, eye are dry and astringent, ophthalmic bloated, ophthalmalgia, photophobia and is improved effect for examination trencherman.
3, sample in test-meal process for observing allergy and other untoward reaction.
After other embodiments of the invention test-meal, its effect and embodiment 1 same or similar.
Claims (9)
1. improve health product for vision, it is characterized in that, the raw material primarily of following weight portion is made: phylloxanthin 20 ~ 40 parts, taurine 40 ~ 60 parts, black currant 5 ~ 10 parts, blue berry 5-10 part.
2. the health product improving vision according to claim 1, is characterized in that, also comprise following raw material: sucrose, dextrin, citric acid, grape essence, magnesium stearate.
3. the health product improving vision according to claim 2, is characterized in that, described health product are made up of the raw material of following parts by weight:
Phylloxanthin 20 ~ 40 parts, taurine 40 ~ 60 parts, black currant 5 ~ 10 parts, blue berry 5-10 part, sucrose 300-450 part, dextrin 200-350 part, citric acid 1-5 part, grape essence 1-5 part, magnesium stearate 1-5 part.
4. the health product improving vision according to claim 3; it is characterized in that, described health product are made up of following raw material by weight: phylloxanthin 28 parts, taurine 52 parts, black currant 8 parts, blue berry 7 parts, sucrose 380 parts, 270 parts, dextrin, citric acid 3 parts, grape essence 2 parts, magnesium stearate 3 parts.
5. a preparation method for the health product of the improvement vision described in claim 3 or 4, is characterized in that, comprise the following steps:
(1) pulverize: phylloxanthin, taurine, black currant, blue berry, sucrose, dextrin, citric acid, magnesium stearate are pulverized respectively;
(2) batch mixing: phylloxanthin and taurine mixing by weight, obtains mixed powder A; Mixed powder A is mixed with sucrose, obtains mixed powder B; By blue berry and dextrin mixing, obtain mixed powder C; Black currant is mixed with citric acid, obtains mixed powder D; Mixed powder C is mixed with mixed powder D, obtains mixed powder E; Mixed powder B is mixed with mixed powder E, obtains total mixed powder;
(3) soft material processed: mixed with ethanol by total mixed powder, obtains mixing soft material;
(4) granulate: granulation of being sieved by soft material, obtains wet granular;
(5) dry: wet granular to be carried out drying, obtains dry granule;
(6) batch mixing tabletting: be dissolved in by grape essence in ethanol, sprays on dry granule, obtains always mixed granule; To always mix granule to mix homogeneously with magnesium stearate, obtain always mixed thing; Carrying out tabletting by always mixing thing, obtaining finished product.
6. the preparation method improving the health product of vision according to claim 5; it is characterized in that; in step (1), sucrose is first pulverized after 80 mesh sieves; phylloxanthin, taurine, blue berry, black currant, dextrin, citric acid cross 80 mesh sieves respectively; magnesium stearate crosses 100 mesh sieves, obtains each raw material fine powder.
7. the preparation method improving the health product of vision according to claim 5, is characterized in that, in step (5), baking temperature is 50-60 DEG C.
8. the preparation method improving the health product of vision according to claim 5, is characterized in that, ethanol described in step (3) is mass fraction 75% ethanol, and ethanol consumption is the 20-30% of mixed powder weight.
9. the preparation method improving the health product of vision according to claim 5, is characterized in that, ethanol described in step (6) is mass fraction 95% ethanol, and ethanol consumption is and glucose essence equivalent.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106072545A (en) * | 2016-06-27 | 2016-11-09 | 北京康倍多生物科技有限公司 | The asthenopic xanthophyll chewable tablet of a kind of alleviation and preparation method |
| CN108030099A (en) * | 2017-12-29 | 2018-05-15 | 广州硕维食品技术有限公司 | It is a kind of effectively to relieve stress the prescription nutrition food and preparation method for improving sleep |
| CN110810695A (en) * | 2019-10-21 | 2020-02-21 | 广东轻工职业技术学院 | Preparation method of cowberry extract effervescent tablets |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072545A (en) * | 2016-06-27 | 2016-11-09 | 北京康倍多生物科技有限公司 | The asthenopic xanthophyll chewable tablet of a kind of alleviation and preparation method |
| CN108030099A (en) * | 2017-12-29 | 2018-05-15 | 广州硕维食品技术有限公司 | It is a kind of effectively to relieve stress the prescription nutrition food and preparation method for improving sleep |
| CN110810695A (en) * | 2019-10-21 | 2020-02-21 | 广东轻工职业技术学院 | Preparation method of cowberry extract effervescent tablets |
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