CN104540836B - 作为精氨酸酶抑制剂的环约束类似物 - Google Patents

作为精氨酸酶抑制剂的环约束类似物 Download PDF

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CN104540836B
CN104540836B CN201380028496.7A CN201380028496A CN104540836B CN 104540836 B CN104540836 B CN 104540836B CN 201380028496 A CN201380028496 A CN 201380028496A CN 104540836 B CN104540836 B CN 104540836B
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disease
arginase
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CN104540836A (zh
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迈克尔·范赞特
冈纳·埃里克·小雅格德曼
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Mars Inc
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    • C—CHEMISTRY; METALLURGY
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
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  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
CN201380028496.7A 2012-04-18 2013-03-13 作为精氨酸酶抑制剂的环约束类似物 Active CN104540836B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261625814P 2012-04-18 2012-04-18
US61/625,814 2012-04-18
PCT/US2013/030930 WO2013158262A1 (en) 2012-04-18 2013-03-13 Ring constrained analogs as arginase inhibitors

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CN104540836A CN104540836A (zh) 2015-04-22
CN104540836B true CN104540836B (zh) 2016-11-09

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US (1) US9200011B2 (enExample)
EP (1) EP2852598B3 (enExample)
JP (1) JP6152167B2 (enExample)
CN (1) CN104540836B (enExample)
AU (1) AU2013249790B2 (enExample)
BR (1) BR112014026057B1 (enExample)
CA (1) CA2870526C (enExample)
IL (1) IL235155B (enExample)
IN (1) IN2014DN09678A (enExample)
MX (1) MX355758B (enExample)
WO (1) WO2013158262A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011242794B2 (en) 2010-04-22 2016-11-24 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
ES2568680T3 (es) 2010-10-26 2016-05-03 Mars, Incorporated Boratos como inhibidores de arginasa
PL410665A1 (pl) 2014-12-29 2016-07-04 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
MX385315B (es) * 2015-06-23 2025-03-14 Calithera Biosciences Inc Composiciones y metodos para inhibir actividad de arginasa.
TWI710565B (zh) 2015-10-30 2020-11-21 美商卡利泰拉生物科技公司 用於抑制精胺酸酶活性之組合物及方法
WO2017085947A1 (ja) * 2015-11-18 2017-05-26 東京応化工業株式会社 アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット及びアルギナーゼ関連疾患検出キット
WO2017086421A1 (ja) * 2015-11-18 2017-05-26 東京応化工業株式会社 アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット、アルギナーゼ関連疾患検出キット、及びアルギナーゼの阻害剤又は活性剤のスクリーニング方法
EP3379248B1 (en) * 2015-11-18 2020-09-23 Tokyo Ohka Kogyo Co., Ltd. Arginase activity measurement method, arginase activity detection kit, arginase-related disease detection kit, and arginase inhibitor or active agent screening method
PL417066A1 (pl) * 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
CA3042878A1 (en) 2016-11-08 2018-05-17 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
WO2018090151A1 (es) * 2016-11-18 2018-05-24 Pontificia Universidad Catolica De Chile Combinación farmacéutica para el tratamiento y prevención de la hipertensión arterial y disfunción vascular
MX378460B (es) 2016-12-22 2025-03-10 Calithera Biosciences Inc Composiciones y métodos para inhibir la actividad de la arginasa.
CN108794517B (zh) * 2017-04-27 2021-03-30 南京谷睿生物科技有限公司 一种精氨酸酶抑制剂及其制备方法与用途
BR112019023582A2 (pt) 2017-05-12 2020-06-02 Calithera Biosciences Inc. Método de preparar (3r,4s)-3-acetamido-4-alil-n-(terc-butil)pirrolidina-3-carboxamida
JP6925163B2 (ja) * 2017-05-16 2021-08-25 東京応化工業株式会社 尿素の測定方法及び尿素検出キット
WO2019120296A1 (en) * 2017-12-22 2019-06-27 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heterocyclic compounds as arginase inhibitors
CA3091365A1 (en) 2018-02-17 2019-08-22 Astrazeneca Ab Arginase inhibitors and methods of use thereof
EA202092086A1 (ru) 2018-03-05 2021-02-09 Аркус Байосайенсиз, Инк. Ингибиторы аргиназы
PL3774843T3 (pl) 2018-03-29 2022-11-14 Molecure Sa Dipeptydowe pochodne piperydyny
AU2019379808C1 (en) * 2018-11-16 2024-01-25 Arcus Biosciences, Inc. Inhibitors of ARG1 and/or ARG2
CN112110944B (zh) * 2019-06-21 2022-02-11 南京谷睿生物科技有限公司 一种化合物及其制备方法和应用
TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011133653A1 (en) * 2010-04-22 2011-10-27 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
CN103249737A (zh) * 2010-10-26 2013-08-14 马尔斯公司 作为精氨酸酶抑制剂的硼酸盐

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1049660A1 (en) 1997-10-10 2000-11-08 The Trustees Of The University Of Pennsylvania Compositions and methods for inhibiting arginase activity
US20090298912A1 (en) 2005-07-01 2009-12-03 The Johns Hopkins University Arginase II: A Target treatment of aging heart and heart failure
HUE046932T2 (hu) 2009-01-26 2020-04-28 Univ Pennsylvania Argináz inhibitorok és felhasználási eljárások

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011133653A1 (en) * 2010-04-22 2011-10-27 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
CN103249737A (zh) * 2010-10-26 2013-08-14 马尔斯公司 作为精氨酸酶抑制剂的硼酸盐

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis of a series of boronated unnatural cyclic amino acids as potential boron neutron capture therapy agents;George W. Kabalka et al.;《Apllied Organometallic Chemistry》;20081231;第22卷;第516-522页 *

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EP2852598A1 (en) 2015-04-01
AU2013249790A1 (en) 2014-12-04
US20150080341A1 (en) 2015-03-19
WO2013158262A1 (en) 2013-10-24
US9200011B2 (en) 2015-12-01
CA2870526C (en) 2020-05-05
AU2013249790B2 (en) 2018-01-25
BR112014026057B1 (pt) 2020-10-13
JP2015516397A (ja) 2015-06-11
EP2852598B1 (en) 2016-05-11
JP6152167B2 (ja) 2017-06-21
HK1209126A1 (en) 2016-03-24
BR112014026057A2 (pt) 2017-06-27
MX355758B (es) 2018-04-27
MX2014012606A (es) 2015-01-19
CN104540836A (zh) 2015-04-22
IN2014DN09678A (enExample) 2015-07-31
EP2852598B3 (en) 2016-10-19
IL235155B (en) 2018-06-28
CA2870526A1 (en) 2013-10-24

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