CA2870526C - Ring constrained analogs as arginase inhibitors - Google Patents
Ring constrained analogs as arginase inhibitors Download PDFInfo
- Publication number
- CA2870526C CA2870526C CA2870526A CA2870526A CA2870526C CA 2870526 C CA2870526 C CA 2870526C CA 2870526 A CA2870526 A CA 2870526A CA 2870526 A CA2870526 A CA 2870526A CA 2870526 C CA2870526 C CA 2870526C
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- CA
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- Prior art keywords
- disease
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- use according
- arginase
- disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261625814P | 2012-04-18 | 2012-04-18 | |
| US61/625,814 | 2012-04-18 | ||
| PCT/US2013/030930 WO2013158262A1 (en) | 2012-04-18 | 2013-03-13 | Ring constrained analogs as arginase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2870526A1 CA2870526A1 (en) | 2013-10-24 |
| CA2870526C true CA2870526C (en) | 2020-05-05 |
Family
ID=47997937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2870526A Active CA2870526C (en) | 2012-04-18 | 2013-03-13 | Ring constrained analogs as arginase inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9200011B2 (enExample) |
| EP (1) | EP2852598B3 (enExample) |
| JP (1) | JP6152167B2 (enExample) |
| CN (1) | CN104540836B (enExample) |
| AU (1) | AU2013249790B2 (enExample) |
| BR (1) | BR112014026057B1 (enExample) |
| CA (1) | CA2870526C (enExample) |
| IL (1) | IL235155B (enExample) |
| IN (1) | IN2014DN09678A (enExample) |
| MX (1) | MX355758B (enExample) |
| WO (1) | WO2013158262A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5898177B2 (ja) | 2010-04-22 | 2016-04-06 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
| CN106008569B9 (zh) | 2010-10-26 | 2020-05-22 | 马尔斯公司 | 作为精氨酸酶抑制剂的硼酸盐及其组合物和用途 |
| PL410665A1 (pl) | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| UA123700C2 (uk) * | 2015-06-23 | 2021-05-19 | Калітера Байосайєнсиз, Інк. | Композиції і способи інгібування активності аргінази |
| RS60695B1 (sr) | 2015-10-30 | 2020-09-30 | Calithera Biosciences Inc | Supstance i postupci za inhibiranje aktivnosti arginaze |
| WO2017085947A1 (ja) * | 2015-11-18 | 2017-05-26 | 東京応化工業株式会社 | アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット及びアルギナーゼ関連疾患検出キット |
| WO2017086421A1 (ja) * | 2015-11-18 | 2017-05-26 | 東京応化工業株式会社 | アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット、アルギナーゼ関連疾患検出キット、及びアルギナーゼの阻害剤又は活性剤のスクリーニング方法 |
| EP3379248B1 (en) * | 2015-11-18 | 2020-09-23 | Tokyo Ohka Kogyo Co., Ltd. | Arginase activity measurement method, arginase activity detection kit, arginase-related disease detection kit, and arginase inhibitor or active agent screening method |
| PL417066A1 (pl) * | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| AU2017356942A1 (en) | 2016-11-08 | 2019-05-23 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
| WO2018090151A1 (es) * | 2016-11-18 | 2018-05-24 | Pontificia Universidad Catolica De Chile | Combinación farmacéutica para el tratamiento y prevención de la hipertensión arterial y disfunción vascular |
| EP3842442B1 (en) | 2016-12-22 | 2023-11-01 | Precision Pharmaceuticals, Inc. | Compositions and methods for inhibiting arginase activity |
| CN108794517B (zh) * | 2017-04-27 | 2021-03-30 | 南京谷睿生物科技有限公司 | 一种精氨酸酶抑制剂及其制备方法与用途 |
| WO2018209290A1 (en) * | 2017-05-12 | 2018-11-15 | Calithera Biosciences, Inc. | Method of preparing (3r,4s)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide |
| JP6925163B2 (ja) * | 2017-05-16 | 2021-08-25 | 東京応化工業株式会社 | 尿素の測定方法及び尿素検出キット |
| US11655260B2 (en) | 2017-12-22 | 2023-05-23 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as arginase inhibitors |
| DK3752251T3 (da) * | 2018-02-17 | 2025-12-15 | Astrazeneca Ab | Arginasehæmmere og fremgangsmåder til anvendelse deraf |
| AU2019229978B2 (en) | 2018-03-05 | 2024-05-30 | Arcus Biosciences, Inc. | Arginase inhibitors |
| CA3094939A1 (en) | 2018-03-29 | 2019-10-03 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
| ES3034676T3 (en) | 2018-11-16 | 2025-08-21 | Arcus Biosciences Inc | Inhibitors of arg1 and/or arg2 |
| CN112110944B (zh) * | 2019-06-21 | 2022-02-11 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和应用 |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9797998A (en) | 1997-10-10 | 1999-05-03 | Trustees Of The University Of Pennsylvania, The | Compositions and methods for inhibiting arginase activity |
| EP1915143A4 (en) | 2005-07-01 | 2009-11-11 | Univ Johns Hopkins | ARGINASE II: TARGET TREATMENT FOR THE AGING HEART AND HEART FAILURE |
| ES2729474T3 (es) | 2009-01-26 | 2019-11-04 | Univ Pennsylvania | Inhibidores de la arginasa y métodos de uso |
| JP5898177B2 (ja) * | 2010-04-22 | 2016-04-06 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
| CN106008569B9 (zh) | 2010-10-26 | 2020-05-22 | 马尔斯公司 | 作为精氨酸酶抑制剂的硼酸盐及其组合物和用途 |
-
2013
- 2013-03-13 IN IN9678DEN2014 patent/IN2014DN09678A/en unknown
- 2013-03-13 CA CA2870526A patent/CA2870526C/en active Active
- 2013-03-13 WO PCT/US2013/030930 patent/WO2013158262A1/en not_active Ceased
- 2013-03-13 MX MX2014012606A patent/MX355758B/es active IP Right Grant
- 2013-03-13 CN CN201380028496.7A patent/CN104540836B/zh active Active
- 2013-03-13 US US14/391,901 patent/US9200011B2/en active Active
- 2013-03-13 JP JP2015506997A patent/JP6152167B2/ja active Active
- 2013-03-13 BR BR112014026057-5A patent/BR112014026057B1/pt active IP Right Grant
- 2013-03-13 EP EP13712088.7A patent/EP2852598B3/en active Active
- 2013-03-13 AU AU2013249790A patent/AU2013249790B2/en not_active Ceased
-
2014
- 2014-10-19 IL IL235155A patent/IL235155B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014DN09678A (enExample) | 2015-07-31 |
| BR112014026057B1 (pt) | 2020-10-13 |
| JP6152167B2 (ja) | 2017-06-21 |
| EP2852598A1 (en) | 2015-04-01 |
| CN104540836A (zh) | 2015-04-22 |
| MX2014012606A (es) | 2015-01-19 |
| EP2852598B3 (en) | 2016-10-19 |
| US9200011B2 (en) | 2015-12-01 |
| US20150080341A1 (en) | 2015-03-19 |
| BR112014026057A2 (pt) | 2017-06-27 |
| CA2870526A1 (en) | 2013-10-24 |
| MX355758B (es) | 2018-04-27 |
| WO2013158262A1 (en) | 2013-10-24 |
| AU2013249790A1 (en) | 2014-12-04 |
| HK1209126A1 (en) | 2016-03-24 |
| CN104540836B (zh) | 2016-11-09 |
| EP2852598B1 (en) | 2016-05-11 |
| JP2015516397A (ja) | 2015-06-11 |
| IL235155B (en) | 2018-06-28 |
| AU2013249790B2 (en) | 2018-01-25 |
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| HK1203853B (en) | Inhibitors of arginase and their therapeutic applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180308 |