CN104534820B - A kind of processing method of the microwave vacuum drying Chinese crude drug Radix Paeoniae Alba - Google Patents
A kind of processing method of the microwave vacuum drying Chinese crude drug Radix Paeoniae Alba Download PDFInfo
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Abstract
The processing method that the invention discloses a kind of microwave vacuum drying Chinese crude drug Radix Paeoniae Alba, cleans white Peony Root fresh goods, removes end to end and radicula, scrapes off crust, and section is put into and carried out microwave vacuum drying in microwave vacuum dryer；Microwave vacuum drying process is: vacuum is 3.0 ± 0.2kPa, and microwave power is 4.5W/g, when in hothouse, white Peony Root temperature stops being dried when being 48 DEG C ± 2 DEG C, and drying time is 10～40min.It is fast that the technical program has processing speed, and operating process is simple, and chemical composition runs off little, the advantages such as energy consumption is little and production efficiency is high, and dry mass is good, solve the existing Radix Paeoniae Alba and are dried in processing technique that generally to there is drying time long, labor intensity is big, is affected the problems such as bigger by natural weather.
Description
Technical field
The processing method that the present invention relates to a kind of Chinese crude drug Radix Paeoniae Alba, does particularly with regard to utilizing microwave vacuum
The processing method of the dry Chinese crude drug Radix Paeoniae Alba.
Background technology
The Radix Paeoniae Alba is one of famous Chinese medicine of China, begins to be loaded in Shennong's Herbal, product in row.Source is
Dry root after ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. peeling decocting in water processing.Its nature and flavor are bitter, sour,
It is slightly cold.Return liver, spleen channel.There is the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, effect of suppressing liver-YANG.The most multiplex
In headache dizziness, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, the disease such as night sweat.
White Peony Root working research present situation:
The light grade of Tong Fu, by the Radix Paeoniae Alba paeoniflorin content of detection distinct methods processing, finds tradition peeling boiling
It is 1.150%；Remove the peel after gross weight boiling and have skin to be respectively 1.544% and 1.439%；Gross weight steam after peeling and
Skin is had to be respectively 2.078% and 1.689%；First remove the peel and have skin to steam respectively 1.912% and 1.750% again；
Remove the peel after sun-dried and have skin to be respectively 1.492% and 1.233%, drawing to steam to be machined with and beneficially improve Radix Paeoniae Alba
The conclusion of paeoniflorin content.Hu Minling etc. by HPLC measure first boiling water boiling (5min) remove the peel afterwards sun-dried, first go
After skin, boiling water boiling (5min) is sun-dried, first remove the peel and steam the Radix Paeoniae Alba Chinese herbaceous peony of (7min) sun-dried and sun-dried 4 kinds of methods afterwards
Medicine glycosides content, the Radix Paeoniae Alba paeoniflorin content that after finding first peeling, boiling water boiling (5min) is processed is the highest.Zhou Danying
Producing Radix Paeoniae Alba Deng using HPLC method to contrast Pan'an, the lower paeoniflorin content of Herb paeony root different sources processing is produced in Anhui,
Finding that at source direct slicing is boiled in the peeling of the fresh Radix Paeoniae Alba, the active ingredient loss of Radix Paeoniae is few, and paeoniflorin content is high,
Quality better.Zhang Yuns etc. are shown experimentally that, re-start through processing in production place soften, after the operation cut into slices, its
Paeoniflorin content is decreased obviously.The processing in production place operation proposing the Radix Paeoniae Alba should remove crust after boiling in putting boiling water
On the basis of Gan Zaoing, increasing is put instead and is removed crust after boiling in boiling water, when solarization to seventy percent is dry, and shave, it is dried,
Thus reduce radix paeoniae alba decoction pieces in the course of processing, because water logging softens and causes the loss again of peoniflorin again.
Thank to Yunlong etc. and measure, by HPLC method, the Radix Paeoniae Alba Radix Paeoniae that place of production direct slicing dries and " Chinese Pharmacopoeia " method is processed
Glycosides content, result shows there was no significant difference.And owing to Radix Paeoniae Alba cortex water holding capacity is strong, by " Chinese Pharmacopoeia "
Method is processed, and typically need 2～4d, time-consuming.And place of production fresh goods direct slicing dries, can add
The dehydrating speed of the fast Radix Paeoniae Alba, general needs 1～2d.Furthermore, place of production direct slicing can reduce white Peony Root from extending
The process that goods contacts with water again to decoction pieces, it is to avoid the loss of peoniflorin.
The Radix Paeoniae Alba is as the genuine medicinal materials in Zhejiang, for one of famous " eight Zhe's ", at the traditional drying in producing region
Method is natural drying, but this method is affected relatively big by natural weather, and the time cycle is long, labor intensity
Greatly, run into rainy for days weather, perishable rotten, have a strong impact on Radix Paeoniae Alba quality.White Peony Root is producing at present
Ground processing, the method being formed without unified standard or more science, the loss of its chemical composition, inevitable
Cause the Quality Down of white Peony Root, the wasting of resources, energy waste and the manpower and materials that same increase is unnecessary
Waste.
It addition, one Radix Paeoniae Alba processing method of " Chinese Pharmacopoeia " version in 2010 is: summer, season in autumn two excavate, clean,
Remove end to end and radicula, put removing crust after boiling in boiling water；Or boil again after peeling, dry.Radix Paeoniae Alba crude drug
Place of production preliminary working is: Chinese crude drug → arrangement → infiltration → section → be dried → radix paeoniae alba decoction pieces, necessary before cutting
Soak and soften to a certain degree, be dried again after cutting into decoction pieces, the most time-consuming take a lot of work, and soak soft
Often there will be during change and hinder the phenomenon such as water or the dry heart, surfaces of tacky, variable color.Therefore, improve and ensure white
The research work of Radix Paeoniae material and prepared slice quality is very important.
In recent years, dry technology is gradually improved and variation, at present conventional have hot air drying, vacuum drying,
Microwave drying, vacuum lyophilization, infrared drying and the new drying method combined between them.
Microwave vacuum drying technology combines microwave heating and two technology of vacuum drying, makes material to be dried exist
When pressure is low, it is possible to by reducing the steam partial pressure in gas phase, reduce its boiling temperature, make material exist
It is dehydrated under low temperature state, quickening moisture diffusion speed, and and oxygen-barrier, preferably protect in material
Chemical composition.Microwave provides thermal source for vacuum drying, directly heats material, makes water or solvent divide
The heat transfer of son is the easiest so that it is can rapid draing, it is thus achieved that good dry result.
The patent documentation of publication number CN101879225A discloses a kind of genuine medicine reducing peoniflorin ingredients from lossing
Material Herb paeony root production and processing method, it is characterised in that take 3 years Radix Paeoniae Alba, root is dug, cuts fleshy tap root,
By diameter stepping, shrug off silt, take 10kg Radix Paeoniae Alba root add 50kg water medicine-washing machine clean；To wash again
The Radix Paeoniae Alba removing silt puts into microwave drying oven, dry heat 8-10 minute；Take out, remove the peel with beaming machine；Again
Medical material is made a gift to someone microwave drying oven, be dried 8-12 minute, to medical material water content at 15-25%；Take out, adjust
The Radix Paeoniae Alba after peeling, to slice thickness specification, is uniformly sent into medicine cutter by transmission belt, section by medicine cutter；
Dry packaging of sieving in time, obtain radix paeoniae alba decoction pieces finished product.The method is still required for drying after being cut into slices by the Radix Paeoniae Alba again
Processing, operating process is complicated, and labor intensity is big, dries process and is restricted by natural weather.
Summary of the invention
In order to solve above-mentioned technical problem, it is an object of the invention to provide a kind of microwave vacuum drying Chinese crude drug
The processing method of the Radix Paeoniae Alba, replaces tradition boiling with microwave vacuum drying and dries and the mode of boiling oven drying,
Having processing speed fast, operating process is simple, and chemical composition runs off little, and energy consumption is little and production efficiency is high, dry
The advantages such as drying quality is good, solve the existing Radix Paeoniae Alba and are dried in processing technique that generally to there is drying time long, labor
Fatigue resistance is big, is affected the problems such as bigger by natural weather.
To achieve the above object, present invention employs following technical scheme:
The processing method of a kind of microwave vacuum drying Chinese crude drug Radix Paeoniae Alba, cleans white Peony Root fresh goods, removes head
Tail and radicula, scrape off crust, section, puts into and carries out microwave vacuum drying in microwave vacuum dryer；Microwave
Vacuum drying process is: vacuum is 3.0 ± 0.2kPa, and microwave power is 4.5W/g, when hothouse words spoken by an actor from offstage
Stopping when Radix Paeoniae material temperature is 48 DEG C ± 2 DEG C being dried, drying time is 10～40min.
As preferably, described white Peony Root fresh goods being cleaned refers to: choosing 3 years Radix Paeoniae Alba medical materials, profile is big
Little, length is uniform, without pest and disease damage, without the Radix Paeoniae Alba of scabbing, shrugs off silt, washes.
As preferably, described drying time is about 12min.
In white Peony Root after using above-mentioned microwave vacuum drying to process: extract content is not less than 40%, polysaccharide
Content is no less than 6.0%, and paeoniflorin content is not less than 3.0%, and Determination of Total Glucosides of Paeony is not less than 6.0%, water content
Between 8.0～12.0%.
Due to the fact that and have employed above technical scheme, with microwave vacuum drying replace tradition boiling dry and
The mode of boiling oven drying, has processing speed fast, and operating process is simple, and chemical composition runs off little, energy
Consume the little and advantage such as production efficiency is high, and dry mass is good, solve the existing Radix Paeoniae Alba and be dried in processing technique general
Store-through is long in drying time, and labor intensity is big, is affected the problems such as bigger by natural weather.
Microwave drying and two technology of vacuum drying are organically combined by the present invention, given full play to microwave drying and
Vacuum drying respective advantage, under vacuum, microwave energy heats the most from inside to outside, makes moisture
Heat transfer is relatively easy, is therefore greatly shortened drying time, and production efficiency is improved, and energy consumption substantially drops
Low.The present invention, by research Radix Paeoniae Alba microwave vacuum drying process, analyzes each technological parameter pair of microwave vacuum drying
The impact of Radix Paeoniae Alba quality, optimizes the optimum process obtaining microwave vacuum drying.The enforcement of this technique can effectively be protected
It is left white in Chinese herbaceous peony contained peoniflorin and Radix Paeoniae Alba total glucosides, reduces the loss of chemical composition, improve the outward appearance of the Radix Paeoniae Alba,
Shorten drying time, improve production efficiency, and microwave itself can play the effect of sterilizing, be conducive to white
The storage of Chinese herbaceous peony.
Patent documentation relative to publication number CN101879225A discloses a kind of peoniflorin ingredients from lossing of reducing
Genuine medicinal materials Herb paeony root production and processing method, white Peony Root fresh goods cleaned by the present invention, remove the peel, cut into slices after adopt
Microwave vacuum drying is carried out, it is no longer necessary to the white Peony Root before and after peeling is carried out repeatedly microwave by optimization technique
It is dried, it is no longer necessary to carry out drying in the shade to kept dry condition (water content less than 13%) by Radix Paeoniae Alba section, but
The direct microwave vacuum drying that carries out Radix Paeoniae Alba section is to kept dry condition (water content less than 13%), the most greatly
Shorten greatly drying time, improve production and processing efficiency, reduce energy consumption and cost of labor, it is to avoid from
So weather impact, and by investigating the indexs such as extractum, peoniflorin and total saponin content, it was demonstrated that the present invention
Technique can reduce the loss of effective ingredient in dry run.
Detailed description of the invention
The following specific embodiments of the present invention is to make a detailed explanation.
The processing method of a kind of microwave vacuum drying Chinese crude drug Radix Paeoniae Alba, cleans white Peony Root fresh goods, removes head
Tail and radicula, scrape off crust, section, puts into and carries out microwave vacuum drying in microwave vacuum dryer；Microwave
Vacuum drying process is: vacuum is 3.0 ± 0.2kPa, and microwave power is 4.5W/g, when hothouse words spoken by an actor from offstage
Stopping when Radix Paeoniae material temperature is 48 DEG C ± 2 DEG C being dried, drying time is 10～40min.Described by white Peony Root
Fresh goods is cleaned and is referred to: choose 3 years Radix Paeoniae Alba medical materials, and profile size, length are uniform, without pest and disease damage, without scabbing
The Radix Paeoniae Alba, shrug off silt, wash.Described drying time is 12min.At described microwave vacuum drying
In white Peony Root after reason: extract content is not less than 40%, polyoses content is no less than 6.0%, and peoniflorin contains
Amount is not less than 3.0%, and Determination of Total Glucosides of Paeony is not less than 6.0%, and water content is between 8.0～12.0%.
Embodiment 1: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 3.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 250W, controls temperature of charge the most out of service between 46 DEG C～50 DEG C, and total is drying time
26min, obtaining dried Radix Paeoniae Alba water content is 9.56%.
Embodiment 2: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 3.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 350W, controls temperature of charge the most out of service between 46 DEG C～50 DEG C, and total is drying time
18min, obtaining dried Radix Paeoniae Alba water content is 10.16%.
Embodiment 3: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 3.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 450W, controls temperature of charge the most out of service between 46 DEG C～50 DEG C, and total is drying time
12min, obtaining dried Radix Paeoniae Alba water content is 9.36%.
Embodiment 4: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 3.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 550W, controls temperature of charge the most out of service between 46 DEG C～50 DEG C, and total drying time is 8min,
Obtaining dried Radix Paeoniae Alba water content is 9.74%.
Embodiment 5: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 9.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 450W, controls temperature of charge the most out of service between 46 DEG C～50 DEG C, and total is drying time
28min, obtaining dried Radix Paeoniae Alba water content is 10.08%.
Embodiment 6: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 7.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 450W, controls temperature of charge the most out of service between 46 DEG C～50 DEG C, and total is drying time
21min, obtaining dried Radix Paeoniae Alba water content is 10.54%.
Embodiment 7: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 5.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 450W, controls temperature of charge the most out of service between 46 DEG C～50 DEG C, and total is drying time
16min, obtaining dried Radix Paeoniae Alba water content is 9.26%.
Embodiment 8: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 3.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 450W, controls temperature of charge the most out of service between 35 DEG C～40 DEG C, and total is drying time
10min, obtaining dried Radix Paeoniae Alba water content is 17.42%.
Embodiment 9: white Peony Root fresh goods is cleaned, removes end to end and radicula, weighs 100g, scrape off crust,
Section, selection vacuum is 3.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave
Power 450W, controls temperature of charge the most out of service between 55 DEG C～60 DEG C, and total is drying time
13min, obtaining dried Radix Paeoniae Alba water content is 6.24%.
Under the conditions of using microwave vacuum, the wet basis water-cut variation being dried initial stage material is the least, along with dry
Proceeding, the hydrone vibrations aggravation within material, more energy transfers heat, moisture content change to
Very big, the phase after the drying, inside material, gradually form loose porous shape, heat conductivity starts to weaken, microwave energy
Amount causes temperature of charge rapid increase, and zooming flex point, between 46 DEG C～50 DEG C, shows temperature of charge
Moisture tends towards stability (moisture is between 8.0%-12.0%).The present invention utilizes ultraviolet spectrophotometry
And high performance liquid chromatography, the sample of above example is carried out polyoses content, paeoniflorin content and the Radix Paeoniae Alba total
The index determining of glycosides content, chemically component loss rate evaluates most preferred embodiment.The results are shown in Table 1.
The different embodiment Radix Paeoniae Alba extract content of table 1 and chemical composition content compare
Show it can be seen that 1. different technical parameters carries out microwave vacuum drying white paeony root sample from table 1 data
Polyoses content scope is 5.87%-7.45%, and along with the increase of microwave power, Radix Paeoniae Alba polysaccharides overall content is decline
Trend, owing to the increase of microwave power can raise the baking temperature of the Radix Paeoniae Alba, high temperature can destroy polysaccharide, so that
Polyoses content reduces.To the later stage of drying, along with the minimizing of material moisture, microwave power is the biggest, in the Radix Paeoniae Alba
Portion's temperature is higher, and it is more that Radix Paeoniae Alba polysaccharides is degraded.Meanwhile, Radix Paeoniae Alba polysaccharides increases with the rising of vacuum,
When microwave power is constant, vacuum is the highest, and the boiling point needed for the evaporation of Radix Paeoniae Alba moisture is the lowest, thus reduces
The temperature of the Radix Paeoniae Alba in dry run.Vacuum is the highest, and the temperature of dry run is the lowest, and polysaccharide is by temperature shadow
Ringing the least, polysaccharide degraded is the fewest, and vacuum is the highest simultaneously, and required drying time is the shortest, the short time
It is dried and also makes polyoses content loss reduce.2. investigate from peoniflorin index components, when vacuum is constant, with
The rising of microwave power, baking temperature is the highest, and drying time is the shortest, white between adjacent microwave power
In Chinese herbaceous peony, the difference of paeoniflorin content reduces, but when microwave power is increased to 550W, easily occurs being charred phenomenon,
Therefore select microwave power 450W to be advisable.Meanwhile, along with the rising of vacuum, in the Radix Paeoniae Alba, paeoniflorin content is slightly
Rise, but between adjacent vacuum degree, paeoniflorin content difference is little, under vacuum conditions, fixing microwave power,
Vacuum is the highest, and the boiling point needed for moisture evaporation is the lowest, correspondingly reduces the baking temperature of the Radix Paeoniae Alba, simultaneously
The time being dried microwave is the shortest, but when vacuum is between 2.0kPa and 100Pa, easily occurs that electric arc (is held
Continue and put blue light) phenomenon, in this vacuum ranges, it is not recommended that use microwave drying.Selection vacuum is 3.0kPa
It is advisable.3. investigate from Radix Paeoniae Alba total glucosides index components, when vacuum is constant, along with the progressively liter of microwave power
Height, Determination of Total Glucosides of Paeony is in being gradually increasing trend, but the difference of Determination of Total Glucosides of Paeony between adjacent microwave power
Reducing, it is the shortest for the highest required drying time that this is possibly due to microwave power, is dried in short-term and can reduce the Radix Paeoniae Alba
The loss of total glycosides content, but when microwave power reaches 550W, easily cause the part Radix Paeoniae Alba and occur being charred phenomenon, shadow
Ring Radix Paeoniae Alba exterior quality and interior quality, therefore select microwave power 450W to be dried, this same paeoniflorin content
Change impact is consistent.Meanwhile, along with the rising of vacuum, Determination of Total Glucosides of Paeony is on the rise, very
Under dummy status, vacuum is the highest, and the boiling point needed for moisture evaporation is the lowest, correspondingly reduces being dried of the Radix Paeoniae Alba
Temperature, decreases the drying time of the Radix Paeoniae Alba, and material is under for a long time at microwave radiation, may reduce
The content of Radix Paeoniae Alba total glucosides, but the difference of changes of contents is the most fairly obvious, owing to, under microwave state, vacuum exists
Arc phenomenon is easily there is, in this vacuum ranges, it is not recommended that use microwave drying between 2.0kPa and 100Pa.
Therefore select vacuum to carry out microwave drying at about 3.0kPa and be advisable.4. when vacuum and microwave power are constant,
Degree of drying depends on the time that microwave drying runs, and in microwave cavity, displays temperature energy side reflects material
Degree of drying, the time is too short, and moisture content of material does not reaches dry requirement, overlong time, and material is easy
Occur be charred phenomenon, under this experimental condition, when in microwave cavity displays temperature between 46 DEG C～50 DEG C, thing
Material moisture substantially between 8.0-12.0%, and displays temperature more than 52 DEG C time, fraction material starts
Yellowing is charred sign, and when displays temperature reaches 60 DEG C, material is charred substantially, and chemical composition is destroyed serious.
Therefore when control displays temperature is between 46 DEG C～50 DEG C, i.e. judge to be dried to terminate.
Checking example:
Take white Peony Root fresh goods to clean, remove end to end and radicula, weigh 100g, scrape off crust, section, choosing
Selecting vacuum is 3.0kPa, puts in microwave drying oven, carries out microwave vacuum drying, selects microwave power 450W,
Controlling temperature of charge the most out of service between 46 DEG C～50 DEG C, total drying time is 12min, totally three parts,
Obtain being dried the chemical composition content result of white Peony Root, be shown in Table 2.
Table 2 microwave vacuum drying checking result of the test
Result above shows: under this drying condition, and in white Peony Root, extract content is not less than 40%, and polysaccharide contains
Amount is no less than 6.5%, and paeoniflorin content is not less than 3.5%, and Determination of Total Glucosides of Paeony is not less than 8.0%, and water content exists
Between 8.0～12.0%.
Comparative example:
Outside the white Peony Root that the microwave vacuum drying of embodiment 3, existing method 1 and existing method 2 are processed
See character, extract content compares, and is shown in Table 3.
Table 3 different processing methods white Peony Root appearance character and extract content compare
Note: existing method 1: clean for white Peony Root fresh goods, removes end to end and radicula, boils to the saturating heart, scrape off
Crust, section, heat drying in baking oven.Existing method 2: for white Peony Root fresh goods clean, remove end to end and
Radicula, boils to the saturating heart, scrapes off crust, and section, ventilation is dried.
Result above shows: microwave vacuum drying compares with existing method 1 and existing method 2, white appearance
Character section texture becomes apparent from, and is more beneficial for the leaching of chemical substance.
In the white Peony Root that the microwave vacuum drying of embodiment 3, existing method 1 and existing method 2 are processed
Polyoses content, paeoniflorin content, Determination of Total Glucosides of Paeony compare, be shown in Table 4.
Table 4 different processing methods white Peony Root chemical composition content compares
Result shows: white Peony Root after 3 different processing methods process, existing method 1 and 2 Radix Paeoniae Alba sample
In product, polyoses content, paeoniflorin content, Determination of Total Glucosides of Paeony all occur in that a certain degree of decline, illustrate to use
Microwave vacuum drying method decreases the loss of chemical composition in white Peony Root, it is taken as that the processing of the present invention is white
The method of Radix Paeoniae material is that science is feasible, can promote the quality of white Peony Root.
The white Peony Root microwave vacuum drying of embodiment 3, existing method 1 and existing method 2 processed is little
Murine virulence comparison, the results are shown in Table 5.
Table 5 white Peony Root different processing methods sample mouse toxicity compares
Result shows, after each treated animal is administered, no abnormality seen, body weight and matched group ratio, body weight increases basic
It is identical, it is taken as that the sample of the inventive method and existing method 1,2 preparation has no any toxicity.
The white Peony Root microwave vacuum drying of embodiment 3, existing method 1 and existing method 2 processed is protected
Protect the effect of mouse liver cell.Use CCl4 to cause mice HepG2 cell injury, add not in culture fluid
With the extracting solution of processing method white Peony Root variable concentrations, observe its protective effect to impaired HepG2 cell.
The results are shown in Table 6.
The impact (Mean ± SEM) on mice HepG2 cell proliferation of the table 6 white Peony Root different processing methods sample
Compare with blank group: * P < 0.05, different processing methods white paeony root sample compares two-by-two: #P < 0.05.
Conclusion: the Radix Paeoniae Alba Aqueous extracts of different processing methods acts on the HepG2 of CCl4 induction and compares pathological model,
The HepG2 cell growth that wherein CCl4 is induced by 50 μ g/ml-400 μ g/ml Radix Paeoniae Alba water extracts all has promotion
Effect (* P < 0.05).When concentration is more than 200 μ g/ml, its action intensity is in the trend of falling after rise.Work as concentration
When being 400 μ g/ml, there is significant difference (#P < 0.05) in existing method 1 and existing method 2, and its
Difference between remaining each dosage group no difference of science of statistics.
Show that different processing mode Radix Paeoniae Alba water carries by the MTT of 25-800 μ g/ml concentration range being screened we
The activity of the HepG2 under CCL4 model is by thing: when mass concentration is 50 μ g/ml-400 μ g/ml,
Radix Paeoniae Alba display increases the trend of HepG2 cell survival rate, when mass concentration is 50 μ g/ml-200 μ g/ml,
In pronounced amount effect relationship, and the Radix Paeoniae Alba general trend of microwave vacuum drying method processing is better than existing method 1 with existing
Having method 2, it is taken as that the drug activity that the white Peony Root of present invention processing has is higher, this becomes with its chemistry
Divide the trend that content is high consistent.
Being embodied as: choose the Radix Paeoniae Alba, choose 3 years Radix Paeoniae Alba medical materials, profile size, length are uniform,
Without pest and disease damage, without the Radix Paeoniae Alba of scabbing, shrugging off silt, tap water is carried out, and cuts into slices with microtome,
Putting into microwave vacuum drying case, holding vacuum is 3.0 ± 0.2kPa, and control microwave power is 4.5W/g,
Controlling Radix Paeoniae Alba temperature 48 DEG C ± 2 DEG C in hothouse, drying time is 12min.
Under this drying condition, in white Peony Root, extract content is not less than 40%, and polyoses content is no less than 6.0%,
Paeoniflorin content is not less than 3.0%, and Determination of Total Glucosides of Paeony is not less than 8.0%, and water content is between 8.0～12.0%.
It is emphasized that: be the most only presently preferred embodiments of the present invention, not the present invention is made any
Pro forma restriction, any simple modification that above example is made by every technical spirit according to the present invention,
Equivalent variations and modification, all still fall within the range of technical solution of the present invention.
Claims (4)
1. the processing method of a microwave vacuum drying Chinese crude drug Radix Paeoniae Alba, it is characterised in that by white Peony Root fresh goods
Clean, remove end to end and radicula, scrape off crust, section, put into microwave vacuum dryer is carried out micro-
Ripple is vacuum dried；Microwave vacuum drying process is: vacuum is 3.0 ± 0.2kPa, and microwave power is
4.5W/g, when in drying machine, white Peony Root temperature stops being dried when being 48 DEG C ± 2 DEG C, drying time is
10～40min.
The processing method of a kind of microwave vacuum drying Chinese crude drug Radix Paeoniae Alba the most according to claim 1, its feature
Being, described white Peony Root fresh goods being cleaned refers to: choose 3 years Radix Paeoniae Alba medical materials, profile size,
Length is uniform, without pest and disease damage, without the Radix Paeoniae Alba of scabbing, shrugs off silt, washes.
The processing method of a kind of microwave vacuum drying Chinese crude drug Radix Paeoniae Alba the most according to claim 1, its feature
Being, described drying time is 12min.
The processing method of a kind of microwave vacuum drying Chinese crude drug Radix Paeoniae Alba the most according to claim 1, its feature
It is, in the white Peony Root after the process of described microwave vacuum drying: extract content is not less than 40%,
Polyoses content is no less than 6.0%, and paeoniflorin content is not less than 3.0%, and Determination of Total Glucosides of Paeony is not less than
8.0%, water content is between 8.0～12.0%.
Priority Applications (1)
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