CN102048764B - Use of microwave drying technique in field of traditional Chinese medicinal extract - Google Patents
Use of microwave drying technique in field of traditional Chinese medicinal extract Download PDFInfo
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- CN102048764B CN102048764B CN200910071156.8A CN200910071156A CN102048764B CN 102048764 B CN102048764 B CN 102048764B CN 200910071156 A CN200910071156 A CN 200910071156A CN 102048764 B CN102048764 B CN 102048764B
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Abstract
The invention relates to a drying method of traditional Chinese medicinal extract, in particular to the use of a microwave drying technique in field of traditional Chinese medicinal extract. The drying method comprises the steps of putting traditional Chinese medicinal extract in drying plates and drying the traditional Chinese medicinal extract in microwave under vacuum, wherein the amount of the extract put in each plate is 0.3 to 6 kilograms, the drying temperature is 60 to 100 DEG C, the return difference temperature is 1 DEG C, the vacuum degree is higher than -0.08MPa and the drying time is 10 to 200 minutes.
Description
Technical field
The present invention relates to a kind of drying means of Chinese medical concrete, particularly microwave drying technology is in the application in Chinese medical concrete field.
Background technology
Chinese medical concrete is divided into fluid extract and dry extract, fluid extract is as the term suggests be flowable extractum, wherein containing more solvent composition, fluid extract concentrate drying can be obtained dry extract, current Chinese medical concrete drying adopts vacuum drying oven dry more, efficiency is low, energy consumption is large, as blood-nourishing and brain-refreshing ball extract dry powder, former drying means adopts vacuum drying process, and man-hour is long, average every dry 1 all ages about needs with 32.9-56.8 hour, efficiency is low, and energy consumption is large, paeoniflorin content loss more (7.25%).
Microwave refers to that wavelength is at 1-0.001m, the electromagnetic wave of frequency range 300-300000MHz, material to be machined under the effect of microwave field (ac high frequency electromagnetic field), no matter polar molecule or nonpolar molecule all repeatedly polarized, frequently because of the variation repeatedly of its polarity fiercely to rotate.Polar molecule produces the violent rotation of 2,400,000,000 times/s frequency, thus produces violent collision and friction, and reaches heating, vaporization, concentrated, to realize the object of drying.In microwave drying, to absorb the ability of microwave different for different material, and moisture has larger absorbability than other material, and in wet stock, moisture obtains more energy and rapid vaporization, and solid material because of absorption microwave ability little, it is very high that temperature can not rise.
In prior art, microwave drying technology can be used for the drying of medicine pill, Chinese medicine extract or the prepared slices of Chinese crude drugs, and microwave drying is not only applied on medicine, chemical industry, food, and is widely used in timber, cardboard, the drying of textile, heating, fixation.
Microwave drying technology is used for carrying out drying to Chinese medical concrete can run into some problems, as the control of condition, to the applicable of specific products and cost payout etc.The present invention finds a kind of drying and sterilization method of Chinese medical concrete through research, is better than the mode of heating that some is traditional in many aspects.
Summary of the invention
The invention provides a kind of drying means of Chinese medical concrete, particularly microwave drying technology is in the application in Chinese medical concrete field.
Method of the present invention comprises the following steps:
1) Chinese medical concrete spreads in basin,
2) microwave vacuum drying is carried out:
Its middle berth dish amount 0.3-6kg/ dish,
Baking temperature 60-100 DEG C,
Return difference temperature 1 DEG C,
More than vacuum-0.08Mpa.
Drying time 10-200 minute
Chinese medical concrete of the present invention can be any one Chinese medical concrete, can be the water extracted immersing paste, and alcohol-extracted extract can be folk prescription drug extract, also can be compound medicine extractum, can select related conditions according to different Chinese medicine kind.
The preferred Chinese medical concrete of the present invention comprises: blood-nourishing and brain-refreshing ball extractum, Radix Isatidis extractum, ANTIWEI ball extractum, Yushu Jiaonang extractum, the quick clever ball extractum of sugar.
Paving dish amount of the present invention is the parameter determined according to the size of equipment, described dish is any plate being applicable to loading extractum, size is as the criterion with applicable equipment, paving dish amount is the amount be poured on by fluid extract in dish, its standard is as the criterion with instrument size, and equipment can spread greatly more, and equipment I spreads less, paving dish amount of the present invention is preferably, operates in suitable equipment of the present invention.
Baking temperature of the present invention is set by the temperature-adjusting device of microwave equipment, and concrete establishing method is determined according to the kind of equipment, and the present invention adopts suitable equipment design temperature of the present invention.
Vacuum of the present invention is set by the vacuum regulator of microwave equipment, and concrete establishing method is determined according to the kind of equipment, and the present invention adopts suitable equipment of the present invention to set vacuum.
Drying time of the present invention is set by the time adjustment device of microwave equipment, and concrete establishing method is determined according to the kind of equipment, and the present invention adopts suitable equipment of the present invention to set drying time.
Preferably, drying means of the present invention, comprises the following steps:
Blood-nourishing and brain-refreshing ball extractum spreads in basin, paving dish amount 2.7-5.8kg/ dish, material design temperature 60-90 DEG C, return difference temperature 1 DEG C (actual temperature is no more than 90 DEG C), and vacuum-0.08Mpa, carries out microwave drying, drying time 10-200 minute.
Preferably, drying means of the present invention, comprises the following steps:
Radix Isatidis extractum spreads in basin, paving dish amount for often dish be no more than 0.35-1.0kg extractum, material design temperature 60-70 DEG C, return difference 1 DEG C, more than vacuum-0.08Mpa, carry out microwave drying, drying time 10-200 minute.
Preferably, drying means of the present invention, comprises the following steps:
ANTIWEI ball extractum spreads in basin, and paving dish amount is 1.5-2.5kg, material design temperature 65-80 DEG C, return difference 1 DEG C, and more than vacuum-0.08Mpa, carry out microwave drying, drying time 10-200 minute.
Preferably, drying means of the present invention, comprises the following steps:
Yushu Jiaonang extractum spreads in basin, and paving dish amount is 2-5kg material design temperature 70-80 DEG C, return difference 1 DEG C, and more than vacuum-0.08Mpa, carry out microwave drying, drying time 10-200 minute.
Preferably, drying means of the present invention, comprises the following steps:
Sugar quick clever ball extractum spread in basin, paving dish amount is 3-4kg, material design temperature 70 DEG C, return difference 1 DEG C, and more than vacuum-0.08Mpa, carry out microwave drying, drying time 10-200 minute.
Below by way of test data, beneficial effect of the present invention is described:
1, for blood-nourishing and brain-refreshing ball extract dry powder:
Take the blood-nourishing and brain-refreshing the water extracted immersing paste of recipe quantity (by Radix Rehmanniae Preparata, Concha Margaritifera, Spica Prunellae, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Herba Asari 6 taste extracting and processing Chinese medicinal materials forms), blood-nourishing and brain-refreshing alcohol-extracted extract is (by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Semen Cassiae 4 taste extracting and processing Chinese medicinal materials), Radix Paeoniae Alba extractum (being processed by white Peony Root extraction), abundant mixing, stir, spread in basin, carry out microwave vacuum drying: paving dish amount 5.5kg/ dish, material design temperature 90 DEG C, return difference temperature 1 DEG C (actual temperature is no more than 90 DEG C), more than vacuum-0.08Mpa, receive dry thing is pulverized, cross 80 orders.
Technique gropes process: setting paving dish amount 5.8kg, design temperature 70 DEG C, power 15.3KW, dry 180 minutes, moisture 5.3%, and pelletizing process has drawing-down phenomenon, preparation weak effect; Setting paving dish amount 2.7kg, design temperature 65 DEG C, power 15.3KW, dry 190 minutes, moisture 6.16%; Setting paving dish amount 5.5kg, design temperature 90 DEG C, power 15.3KW, dry 90 minutes, moisture 3.98%, pelletizing process was smooth, and preparation is qualified.
Beneficial effect
After patent working, production capacity increases more than 20 times, Contrast on effect situation:
| Project | Vacuum drying oven is dry | Vacuum microwave drying |
| Drying process man-hour (20,000 bags) | 58.5 hours | 2.92 hour |
| Extractum quality | All qualified | All qualified |
| Dry yield | 90％ | 98％ |
| Peoniflorin loss rate | 7.25％ | 5％ |
2, for Radix Isatidis dry extract:
Radix Isatidis extractum is processed by chromatogram of Radix Isatidis extraction, and extractum carries out microwave vacuum drying, and paving dish amount is no more than 1.00kg extractum, power material design temperature 60 DEG C, return difference 1 DEG C, more than vacuum-0.08Mpa, 50 minutes drying times for often coiling.
Beneficial effect
After patent working, production capacity increases, Contrast on effect situation:
| Project | Vacuum drying oven is dry | Vacuum microwave drying |
| Drying process man-hour (20,000 bags) | 108-120 hour | 36-48 hour |
| Extractum quality | Dry extract color is dark | Dry extract is of light color |
| Melting | Dark, a little floccule of solution colour | Solution colour is shallow, clear |
3, for ANTIWEI ball extract dry:
ANTIWEI ball extractum is made up of extracting and processing Chinese medicinal materials such as Rhizoma Imperatae, Radix Puerariae, bitter stir-baked SEMEN ARMENIACAE AMARUM, Herba Ephedrae, Ramulus Cinnamomi and Rhizoma Zingiberiss, the microwave drying condition of ANTIWEI ball extractum: drying time 150min, paving dish amount 2.5kg., more than vacuum-0.08MPa.
Beneficial effect
Drying under reduced pressure every case process extractum 15kg, 7 hours production cycles, and adopt microwave drying every case process extractum 15kg, 2.5 hours production cycles, the production cycle shortens greatly.The simultaneously index components rate of transform of product and the equal no significant difference of preparation effect.
4, for Yushu Jiaonang extract dry:
Yushu Jiaonang extractum is made up of extracting and processing Chinese medicinal materials such as the Radix Paeoniae Alba, Herba Hyperici Monogyni, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis, Cortex Albiziae, Radix Polygalae, Radix Morindae Officinalis, Fructus Tribulis.Yushu Jiaonang extractum microwave drying condition: drying time 100min, paving dish amount 5kg, more than vacuum-0.08MPa.
. beneficial effect
Drying under reduced pressure every case process extractum 20kg, 16 hours production cycles, and adopt microwave drying every case process extractum 30kg, production cycle 100min, the production cycle (identical extractum production capacity) shortens to 6.9% of drying under reduced pressure greatly.
5, for the quick clever ball extract dry of sugar:
The quick clever ball extractum of sugar is made up of extracting and processing Chinese medicinal materials such as the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Coptidis, Fructus Mume, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, the Rhizoma Pinelliae (clearly), Radix Scutellariae, Radix Trichosanthis, Fructus Crataegis, sugar quick clever ball extractum microwave drying condition: drying time 60min, paving dish amount 3kg., more than vacuum-0.08MPa
Beneficial effect
Drying under reduced pressure every case process extractum 44kg, 24 hours production cycles, and adopt microwave drying every case process extractum 18kg, production cycle 60min, the production cycle (identical extractum production capacity) shortens to 1/10th of drying under reduced pressure greatly.
Detailed description of the invention:
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Take the blood-nourishing and brain-refreshing the water extracted immersing paste of recipe quantity (by Radix Rehmanniae Preparata, Concha Margaritifera, Spica Prunellae, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Herba Asari 6 taste extracting and processing Chinese medicinal materials forms), blood-nourishing and brain-refreshing alcohol-extracted extract is (by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Semen Cassiae 4 taste extracting and processing Chinese medicinal materials), Radix Paeoniae Alba extractum (being processed by white Peony Root extraction), abundant mixing, stir, spread in basin, carry out microwave vacuum drying: paving dish amount 5.5kg/ dish, material design temperature 90 DEG C, return difference temperature 1 DEG C (actual temperature is no more than 90 DEG C), more than vacuum-0.08Mpa, receive dry thing is pulverized, cross 80 orders.
Embodiment 2
Radix Isatidis extractum is processed by chromatogram of Radix Isatidis extraction, and extractum carries out microwave vacuum drying, and paving dish amount is no more than 1.00kg extractum, power material design temperature 60 DEG C, return difference 1 DEG C, more than vacuum-0.08Mpa, 50 minutes drying times for often coiling.
Embodiment 3
ANTIWEI ball extractum is made up of extracting and processing Chinese medicinal materials such as Rhizoma Imperatae, Radix Puerariae, bitter stir-baked SEMEN ARMENIACAE AMARUM, Herba Ephedrae, Ramulus Cinnamomi and Rhizoma Zingiberiss, the microwave drying condition of ANTIWEI ball extractum: drying time 150min, paving dish amount 2.5kg., more than vacuum-0.08MPa.
Embodiment 4
Yushu Jiaonang extractum is made up of extracting and processing Chinese medicinal materials such as the Radix Paeoniae Alba, Herba Hyperici Monogyni, Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis, Cortex Albiziae, Radix Polygalae, Radix Morindae Officinalis, Fructus Tribulis.Yushu Jiaonang extractum microwave drying condition: drying time 100min,
Embodiment 5
The quick clever ball extractum of sugar is made up of extracting and processing Chinese medicinal materials such as the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Coptidis, Fructus Mume, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, the Rhizoma Pinelliae (clearly), Radix Scutellariae, Radix Trichosanthis, Fructus Crataegis, sugar quick clever ball extractum microwave drying condition: drying time 60min, paving dish amount 3kg., more than vacuum-0.08MPa.
Claims (3)
1. a drying means for Chinese medical concrete, is characterized in that, comprises the following steps:
1) Chinese medical concrete spreads in basin,
2) microwave vacuum drying is carried out:
Its middle berth dish amount 5.5kg/ dish,
Baking temperature 90 DEG C,
Return difference temperature 1 DEG C,
More than vacuum-0.08Mpa,
90 minutes drying times,
Wherein said Chinese medical concrete is blood-nourishing and brain-refreshing ball extractum,
Blood-nourishing and brain-refreshing ball extractum is by blood-nourishing and brain-refreshing the water extracted immersing paste, blood-nourishing and brain-refreshing alcohol-extracted extract and Radix Paeoniae Alba extractum composition, wherein, blood-nourishing and brain-refreshing the water extracted immersing paste is formed by Radix Rehmanniae Preparata, Concha Margaritifera, Spica Prunellae, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Herba Asari 6 taste extracting and processing Chinese medicinal materials, blood-nourishing and brain-refreshing alcohol-extracted extract is formed by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Semen Cassiae 4 taste extracting and processing Chinese medicinal materials, and Radix Paeoniae Alba extractum is extracted by white Peony Root and processes.
2. the drying means of claim 1, it is characterized in that, wherein said drying means, comprise the following steps: the blood-nourishing and brain-refreshing the water extracted immersing paste taking recipe quantity, blood-nourishing and brain-refreshing alcohol-extracted extract, Radix Paeoniae Alba extractum, abundant mixing, stir, spread in basin, carry out microwave vacuum drying, wherein, blood-nourishing and brain-refreshing the water extracted immersing paste is by Radix Rehmanniae Preparata, Concha Margaritifera, Spica Prunellae, Ramulus Uncariae Cum Uncis, Caulis Spatholobi, Herba Asari 6 taste extracting and processing Chinese medicinal materials forms, blood-nourishing and brain-refreshing alcohol-extracted extract is by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, Semen Cassiae 4 taste extracting and processing Chinese medicinal materials forms, Radix Paeoniae Alba extractum is extracted by white Peony Root and processes.
3. the drying means of claim 1, is characterized in that, wherein said microwave refers to that wavelength is at 1-0.001m, the electromagnetic wave of frequency range 300-300000MHz.
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103134272A (en) * | 2011-11-23 | 2013-06-05 | 天津天士力现代中药资源有限公司 | Radix isatidis extraction drying method |
| CN103877242A (en) * | 2012-12-21 | 2014-06-25 | 天士力制药集团股份有限公司 | Pharmaceutical composition for treating headache and application thereof |
| EA030048B1 (en) * | 2012-12-21 | 2018-06-29 | Тасли Фармасьютикал Груп Ко., Лтд. | Pharmaceutical composition for treating headache, traumatic cranial nerve syndrome, dizziness and vertigo, vexation and irritability, insomnia and/or dreaminess and preparation method thereof |
| CN103697665A (en) * | 2013-11-28 | 2014-04-02 | 浙江康恩贝制药股份有限公司 | Drying method of traditional Chinese medicine thick paste |
| CN105021634A (en) * | 2014-04-25 | 2015-11-04 | 天津天士力现代中药资源有限公司 | Rapid microwave moisture measurement method for fluid extract and extract |
| CN104534820B (en) * | 2014-11-28 | 2016-11-02 | 浙江省中医药研究院 | A kind of processing method of the microwave vacuum drying Chinese crude drug Radix Paeoniae Alba |
| CN106403510B (en) * | 2015-07-29 | 2019-02-19 | 广西梧州制药（集团）股份有限公司 | A kind of convection current is total to application of the microwave heat transfer type in being dried under reduced pressure |
| CN105043029A (en) * | 2015-08-20 | 2015-11-11 | 倪勤华 | Drying method for Chinese medical extract |
| CN109556352B (en) * | 2018-11-30 | 2021-01-08 | 山西仁源堂药业有限公司 | Drying method of traditional Chinese medicine fluid extract |
| CN113730491A (en) * | 2021-09-09 | 2021-12-03 | 辽宁中医药大学 | Microwave vacuum drying process for intelligence-developing depression-relieving traditional Chinese medicine extract |
| CN115569068B (en) * | 2022-11-10 | 2023-03-21 | 山东华农生物制药有限公司 | Traditional Chinese medicine extract preparation method and system |
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| CN101254226A (en) * | 2007-12-19 | 2008-09-03 | 游洪涛 | Duliang compound chinese medicine soft capsules and preparation process thereof |
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| CN2620843Y (en) * | 2003-04-05 | 2004-06-16 | 吴琦 | Microwave vacuum drier for extractive material |
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