CN104547660A - Leukocyte generation preparation with high icariin content and processing method of leukocyte generation preparation - Google Patents
Leukocyte generation preparation with high icariin content and processing method of leukocyte generation preparation Download PDFInfo
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- CN104547660A CN104547660A CN201410701679.7A CN201410701679A CN104547660A CN 104547660 A CN104547660 A CN 104547660A CN 201410701679 A CN201410701679 A CN 201410701679A CN 104547660 A CN104547660 A CN 104547660A
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Abstract
The invention discloses a leukocyte generation preparation with high icariin content and a processing method of the leukocyte generation preparation. The processing method comprises the following steps: feeding madder, reed rhizome, lycium barbarum, liquorice, astragalus membranaceus, angelica sinensis, caulis Spatholobi, fructus psoraleae, radix ophiopogonis and monkshood (prepared) into an extraction tank, adding water to soak the components, heating till being boiled, further adding herba epimedii, keeping boiling for 0.5-1.5 hours, filtering, concentrating, performing alcohol precipitation, and removing alcohol, thereby obtaining the leukocyte generation preparation. The processing method has the advantages that as madder, reed rhizome, lycium barbarum, liquorice, astragalus membranaceus, angelica sinensis, caulis Spatholobi, fructus psoraleae, radix ophiopogonis and monkshood (prepared) are firstly fed into the extraction tank, water is added to soak the components, the components are heated till being boiled, and herba epimedii is secondly added, the content of the finished icariin product in the leukocyte generation preparation is as high as 19mg/10ml.
Description
Technical field
This invention relates to Chinese medicine processing method field.
Technical background
The patent No. 2008100071891 is called: a kind of for the leukopenic medicine of prevention and therapy in tumor chemoradiotherapy process, be Ben Shengbai mixture, its formula is: Herba Epimedii, Fructus Psoraleae, Radix Aconiti Lateralis Preparata (system), Fructus Lycii, the Radix Astragali, Caulis Spatholobi, Radix Rubiae, Radix Angelicae Sinensis, Rhizoma Phragmitis, Radix Ophiopogonis, Radix Glycyrrhizae.Its processing method is: be mixed Herba Epimedii, Fructus Psoraleae, Radix Aconiti Lateralis Preparata (system), Fructus Lycii, the Radix Astragali, Caulis Spatholobi, Radix Rubiae, Radix Angelicae Sinensis, Rhizoma Phragmitis, Radix Ophiopogonis, Radix Glycyrrhizae decoction, then filters, concentrates, precipitate with ethanol, receipts alcohol.Its weak point is that all raw materials are mixed decoction, and the Icariin content loss after processing wherein contained by Herba Epimedii is very large, and the Icariin content contained by Herba Epimedii is only about 10mg/10ml.
Summary of the invention
Object of the present invention is exactly is the decoction that is mixed by all raw materials for existing Ben Shengbai mixture processing method, Icariin content loss after processing wherein contained by Herba Epimedii is very large, deficiency, and provide a kind of white mixture processing method of life with high-content icariin.
Processing method of the present invention is: by Radix Rubiae, Rhizoma Phragmitis, Fructus Lycii, Radix Glycyrrhizae, the Radix Astragali, Radix Angelicae Sinensis, Caulis Spatholobi, Fructus Psoraleae, Radix Ophiopogonis, Radix Aconiti Lateralis Preparata (system) drop in extraction pot, after soaking, be heated to boil, drop into Herba Epimedii again, keep boiling 1 hour, then filter, concentrate, precipitate with ethanol, receipts alcohol.
Advantage: again in adding man-hour, first by Radix Rubiae, Rhizoma Phragmitis, Fructus Lycii, Radix Glycyrrhizae, the Radix Astragali, Radix Angelicae Sinensis, Caulis Spatholobi, Fructus Psoraleae, Radix Ophiopogonis, Radix Aconiti Lateralis Preparata (system) drop in extraction pot, after soaking, be heated to boil, drop into Herba Epimedii again, in the white mixture of life after its processing, in its finished product, the content of icariin is up to 19mg/10ml.
Detailed description of the invention
Concrete processing method is:
A. extract: prescription Chinese crude drug drops in extraction pot successively by Radix Rubiae, Rhizoma Phragmitis, Fructus Lycii, Radix Glycyrrhizae, the Radix Astragali, Radix Angelicae Sinensis, Caulis Spatholobi, Fructus Psoraleae, Radix Ophiopogonis, Radix Aconiti Lateralis Preparata (system), and add water 8 times amount, after soaking half an hour, be heated to boil, add Herba Epimedii, keep boiling 1 hour, filter, collect filtrate, medicinal residues add 8 times of water gagings, are heated to boil, keep boiling 1 hour, filter, merging filtrate, medicinal residues discard.
B. concentrate: filtrate is put into dual-effect concentrator decompression (vacuum-0.05-0.07Mpa, temperature 70-80 DEG C) and be concentrated into relative density 1.24 ~ 1.27(25 ± 5 DEG C).
C. precipitate with ethanol: add ethanol to alcohol content 70%, leaves standstill 72 hours, filters.
D. alcohol is received: filtrate recycling ethanol is extremely without alcohol taste.Filtrate is put into decompression concentrator decompression (vacuum-0.06-0.08Mpa, temperature 70-80 DEG C) and be concentrated into relative density 1.24 ~ 1.27(25 ± 5 DEG C).。
E. dosing, cold preservation: extractum adds Purified Water q. s and stirs, and boils 30 minutes, is cooled to room temperature (25 ~ 30 DEG C), cold preservation (4 ~ 10 DEG C) 48 hours, filters, adds steviosin 2.0 ‰; By 20%NaOH solution adjust ph to 7.0, accurately mend purified water to full dose, filter.
F. embedding: fill after reason bottle, every bottle of 10ml, 20 ml, 250ml.
G. sterilizing: 10ml, 20 ml, 250ml:100 DEG C flowing steam sterilization 30 minutes;
Measured by repeatedly repeated trials, the content of its icariin is all up to more than 19mg/10ml.
Reaction mechanism: be likely when all raw materials are decocted together, due to the effect of enzyme, decompose part icariin, Icariin content is reduced, as first decocted by other raw material except Herba Epimedii, after making the enzyme deactivation of decomposition icariin wherein, then put into Herba Epimedii decoction, its icariin would not be decomposed, thus Icariin content is high.
Claims (1)
1. there is the white mixture processing method of life of high-content icariin, it is characterized in that synthetic method is:
By Radix Rubiae, Rhizoma Phragmitis, Fructus Lycii, Radix Glycyrrhizae, the Radix Astragali, Radix Angelicae Sinensis, Caulis Spatholobi, Fructus Psoraleae, Radix Ophiopogonis, Radix Aconiti Lateralis Preparata (system) drop in extraction pot, after soaking, be heated to boil, drop into Herba Epimedii again, keep boiling 0.5-1.5 hour, then filter, concentrate, precipitate with ethanol, receipts alcohol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410701679.7A CN104547660A (en) | 2014-11-28 | 2014-11-28 | Leukocyte generation preparation with high icariin content and processing method of leukocyte generation preparation |
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| CN201410701679.7A CN104547660A (en) | 2014-11-28 | 2014-11-28 | Leukocyte generation preparation with high icariin content and processing method of leukocyte generation preparation |
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| CN104547660A true CN104547660A (en) | 2015-04-29 |
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| CN201410701679.7A Pending CN104547660A (en) | 2014-11-28 | 2014-11-28 | Leukocyte generation preparation with high icariin content and processing method of leukocyte generation preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112014481A (en) * | 2019-05-29 | 2020-12-01 | 湖北梦阳药业股份有限公司 | Detection method of fingerprint spectrum of Shengbai oral liquid |
| WO2020238420A1 (en) * | 2019-05-29 | 2020-12-03 | 湖北梦阳药业股份有限公司 | Drug for treating leukopenia, preparation method therefor and use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101234181A (en) * | 2008-02-04 | 2008-08-06 | 邵振启 | Medicament for preventing and treating leukopenia used in tumor radiotherapy and chemotherapy course |
| JP2010022350A (en) * | 2008-07-17 | 2010-02-04 | Yutaka Yoshida | Method for extracting essence of bamboo shoot |
| CN103720892A (en) * | 2013-12-12 | 2014-04-16 | 辽宁康辰药业有限公司 | Traditional Chinese medicine composition comprising herba epimedii and preparation method of traditional Chinese medicine composition |
-
2014
- 2014-11-28 CN CN201410701679.7A patent/CN104547660A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101234181A (en) * | 2008-02-04 | 2008-08-06 | 邵振启 | Medicament for preventing and treating leukopenia used in tumor radiotherapy and chemotherapy course |
| JP2010022350A (en) * | 2008-07-17 | 2010-02-04 | Yutaka Yoshida | Method for extracting essence of bamboo shoot |
| CN103720892A (en) * | 2013-12-12 | 2014-04-16 | 辽宁康辰药业有限公司 | Traditional Chinese medicine composition comprising herba epimedii and preparation method of traditional Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 刘茂柏等: "《安全用药指导手册》", 30 April 2014, 厦门大学出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112014481A (en) * | 2019-05-29 | 2020-12-01 | 湖北梦阳药业股份有限公司 | Detection method of fingerprint spectrum of Shengbai oral liquid |
| WO2020238420A1 (en) * | 2019-05-29 | 2020-12-03 | 湖北梦阳药业股份有限公司 | Drug for treating leukopenia, preparation method therefor and use thereof |
| EP3888670A4 (en) * | 2019-05-29 | 2022-06-15 | Hubei Monyan Pharmaceutical Co., Ltd. | Drug for treating leukopenia, preparation method therefor and use thereof |
| AU2020281973B2 (en) * | 2019-05-29 | 2023-07-13 | Hubei Monyan Pharmaceutical Co., Ltd. | Drug for treating leukopenia, preparation method therefor and use thereof |
| US11801280B2 (en) | 2019-05-29 | 2023-10-31 | Hubei Monyan Pharmaceutical Co., Ltd. | Drug for treating leukopenia, preparation method thereof and use thereof |
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Application publication date: 20150429 |