CN103877459A - Compound Chinese herbal medicine capable of treating grass carp ichthyophthirius multifiliis and its production method - Google Patents

Abstract

The invention discloses a compound Chinese herbal medicine capable of treating grass carp ichthyophthirius multifiliis and its production method, the compound Chinese herbal medicine capable of treating grass carp ichthyophthirius multifiliis comprises 9 Chinese herbal medicines: the proportion of 9 Chinese herbal medicines of sweet wormwood, dryopteris crasirhitom nakai, radix stemonae, catnip, caulis perllae, sophora flavescens, dried orange peel, phellodendron and pomegranate rind is 18: 15: 21: 10: 8: 6: 8: 11: 7. The production method for the compound Chinese herbal medicine comprises the following steps: 1)decocting and extracting for first time; 2) decocting for second time; 3) performing double-effect concentration; and 4)spray drying. The production method is simple and easy to understand, the compound Chinese herbal medicine can adjust the immunization system to fish, so that the anti-stress capability and immunization function of the grass carp are increased, production performance and feed utilization rate of the grass carp are increased, and various disease of the grass carp can be prevented and treated.

Description

Compound Chinese herb and the manufacture method thereof of the little melonworm for the treatment of Ctenopharyngodon idellus

 

Technical field

The invention belongs to the Chinese herbal medicine for aquatic animal, be specifically related to a kind of compound Chinese herb and manufacture method thereof for the treatment of the little melonworm of Ctenopharyngodon idellus.

 

Background technology

Ichthyophthirius multifiliis is a kind of universal parasite of freshwater fishes, little melonworm breeding rapidly, again live body parasitism simultaneously, for different Fish, the parasitic quantity difference of little melonworm, Individual Size is variant, preference parasitic site is also different, the vesicle that little melonworm stimulates fish body secreting mucus and hamartoplasia to form, makes medicine be difficult to infiltration and is killed, and brings tremendous economic to damage husband once ichthyophthiriasis breaks out just to fish production.Therefore, the study on prevention of ichthyophthiriasis always is the Focal point and difficult point in aquatic science research.Formaldehyde, malachite green oxalate, copper sulfate, quinine, methylene blue, Mercury protonitrate., mercurous acetate, Sal etc. are separately or be mixed for treating ichthyophthiriasis, have certain curative effect, but the mechanism of action difference of various medicines is different, and above-mentioned most medicine high residue, toxic and side effects is strong, and can affect ingesting and growing of fish, can not admix and raise and can heavy dose ofly use.

 

Summary of the invention

The problems referred to above that exist in order to overcome prior art field, the object of the invention is to, a kind of compound Chinese herb and manufacture method thereof for the treatment of the little melonworm of Ctenopharyngodon idellus is provided, and the method for the preventing and treating toxic and side effects that solves current Ctenopharyngodon idellus ichthyophthiriasis is strong, and can affect the problem of ingesting and growing of fish.

Compound Chinese herb and the manufacture method thereof of the little melonworm for the treatment of Ctenopharyngodon idellus provided by the invention, the compound Chinese herb of the little melonworm of described treatment Ctenopharyngodon idellus comprises 9 taste Chinese herbal medicine, and described 9 taste Chinese herbal medicine ratios are Herba Artemisiae Annuae: Rhizoma Osmundae: the Radix Stemonae: Herba Schizonepetae: Caulis Perillae: Radix Sophorae Flavescentis: Pericarpium Citri Reticulatae: Cortex Phellodendri: Pericarpium Granati=18:15:21:10:8:6:8:11:7.

The manufacture method of the compound Chinese herb of the little melonworm for the treatment of Ctenopharyngodon idellus, it comprises following concrete steps:

(1) decoct and extract for the first time: first multifunctional extracting pot cleanout door is closed, extraction pot top dog-house is opened, in proportion 9 taste Chinese herbal medicine are dropped in extraction pot, open extraction pot inlet valve, to the drinking water that is metered into 8 times of amounts of middle dose in extraction pot, close inlet valve and dog-house, open steam valve, be heated to 40 ℃, warm macerating, after 30 minutes, continues to be heated to boiling, in decoction process, observe at any time steam gage, thermometer and extraction pot Pressure gauge numerical value, and recording start boiling time, temperature, now jacket steam pressure keeps 0.02Mpa, decoct temperature and be controlled at 100 ℃ of left and right, in tank, keep fluidized state, decoct 2 hours, decoction process should constantly be observed decoction situation from visor, adjust at any time steam pressure, after decocting 2 hours, steam off valve, open the fluid valve of extraction pot, decocting liquid is crossed to 200 order filters, squeeze in fluid reservoir, drawing liquid is complete, on fluid reservoir, hang Status Flag, indicate decoction liquor title, lot number, quantity, date, operator etc.,

(2) decoct for the second time: open extraction pot inlet valve, be metered into 6 times of amount drinking waters, open steam valve and repeat the above operation that decocts, decocting liquid is crossed to 200 order filters after decocting 2 hours, squeeze in fluid reservoir, medicinal liquid total amount must not be lower than 3500L, and operating process has special messenger to carry out process monitoring, and makes a record;

(3) economic benefits and social benefits are concentrated: first by the vacuum of dual-effect concentrator, cooling water valve is opened, by medicinal liquid suction dual-effect concentrator, open steam valve and carry out concentrating under reduced pressure, evaporating temperature: an effect 75-85 ℃, two effect 60-70 ℃, vacuum: effect-0.03～-0.04Mpa, two effect-0.06～-0.07Mpa, in concentration process, to notice at any time that each table numerical control is in safety range, and perform record, concentrate while closely end, open the feed opening graduated cylinder of heater and collect concentrated solution, with gravity Baume instrumentation proportion, as inadequate in proportion, should continue to concentrate, until concentrated solution relative density reaches at 1.05 o'clock, get final product 60 ℃ of surveys, close vacuum valve, steam valve and cooling water valve, open the atmospheric valve of vaporization chamber, put cream,

(4) spraying is dry squeezes into concentrated solution in spray dryer and sprays and be dried, and obtains the former medicine of extract, adds carrier 20%, synergist 5% simultaneously.

Compound Chinese herb and the manufacture method thereof of the little melonworm for the treatment of Ctenopharyngodon idellus provided by the invention, its beneficial effect is, this manufacture method is easily understood, compound Chinese herb is adjusted the immune system of Fish, improve anti-stress ability and the immune function of Ctenopharyngodon idellus, can improve Ctenopharyngodon idellus fertility performance and efficiency of feed utilization, prevent and treat again the various diseases of Ctenopharyngodon idellus.

 

The specific embodiment

Below in conjunction with embodiment, to compound Chinese herb and the manufacture method thereof of the little melonworm for the treatment of Ctenopharyngodon idellus provided by the invention, be described in detail.

Embodiment

Compound Chinese herb and the manufacture method thereof of the little melonworm for the treatment of Ctenopharyngodon idellus of the present embodiment, the compound Chinese herb of the little melonworm of described treatment Ctenopharyngodon idellus comprises 9 taste Chinese herbal medicine, and described 9 taste Chinese herbal medicine ratios are Herba Artemisiae Annuae: Rhizoma Osmundae: the Radix Stemonae: Herba Schizonepetae: Caulis Perillae: Radix Sophorae Flavescentis: Pericarpium Citri Reticulatae: Cortex Phellodendri: Pericarpium Granati=18:15:21:10:8:6:8:11:7.

The manufacture method of the compound Chinese herb of the little melonworm for the treatment of Ctenopharyngodon idellus, it comprises following concrete steps:

(1) decoct and extract for the first time: first multifunctional extracting pot cleanout door is closed, extraction pot top dog-house is opened, in proportion 9 taste Chinese herbal medicine are dropped in extraction pot, open extraction pot inlet valve, to the drinking water that is metered into 8 times of amounts of middle dose in extraction pot, close inlet valve and dog-house, open steam valve, be heated to 40 ℃, warm macerating, after 30 minutes, continues to be heated to boiling, in decoction process, observe at any time steam gage, thermometer and extraction pot Pressure gauge numerical value, and recording start boiling time, temperature, now jacket steam pressure keeps 0.02Mpa, decoct temperature and be controlled at 100 ℃ of left and right, in tank, keep fluidized state, decoct 2 hours, decoction process should constantly be observed decoction situation from visor, adjust at any time steam pressure, after decocting 2 hours, steam off valve, open the fluid valve of extraction pot, decocting liquid is crossed to 200 order filters, squeeze in fluid reservoir, drawing liquid is complete, on fluid reservoir, hang Status Flag, indicate decoction liquor title, lot number, quantity, date, operator etc.,

(2) decoct for the second time: open extraction pot inlet valve, be metered into 6 times of amount drinking waters, open steam valve and repeat the above operation that decocts, decocting liquid is crossed to 200 order filters after decocting 2 hours, squeeze in fluid reservoir, medicinal liquid total amount must not be lower than 3500L, and operating process has special messenger to carry out process monitoring, and makes a record;

(3) economic benefits and social benefits are concentrated: first by the vacuum of dual-effect concentrator, cooling water valve is opened, by medicinal liquid suction dual-effect concentrator, open steam valve and carry out concentrating under reduced pressure, evaporating temperature: an effect 75-85 ℃, two effect 60-70 ℃, vacuum: effect-0.03～-0.04Mpa, two effect-0.06～-0.07Mpa, in concentration process, to notice at any time that each table numerical control is in safety range, and perform record, concentrate while closely end, open the feed opening graduated cylinder of heater and collect concentrated solution, with gravity Baume instrumentation proportion, as inadequate in proportion, should continue to concentrate, until concentrated solution relative density reaches at 1.05 o'clock, get final product 60 ℃ of surveys, close vacuum valve, steam valve and cooling water valve, open the atmospheric valve of vaporization chamber, put cream,

(4) spraying is dry squeezes into concentrated solution in spray dryer and sprays and be dried, and obtains the former medicine of extract, adds carrier 20%, synergist 5% simultaneously.

Select healthy Experimental fish 216 tails, raise respectively in the cylinder of 12 0.56 cubic metre, every cylinder is put 18 tails, if 3 repetitions, fish body weight is (32.5 ± 6.3) g, the half that every day, quantity of exchanged water was cumulative volume, support 3 days temporarily, eat food when normal Deng experimental group, with the kind medical herbs 30ppm full pool spilling head of our development, the pharmaceutical chemistry of throwing something and feeding of being simultaneously satiated with food, addition is respectively 0g/kg, 10g/kg, 20g/kg, 40g/kg, throw something and feed twice, treat the residual bait of fish sucking-off on a full stomach, after continuous detecting 24 hours, detected once every 12 hours, experiment finds to throw something and feed 20g/kg, , little melonworm obviously reduces when 40g/kg the 3rd day, after 5 days, only have a cylinder to detect a small amount of little melonworm.

Claims (2)

1. treat the compound Chinese herb of the little melonworm of Ctenopharyngodon idellus for one kind, it is characterized in that: the compound Chinese herb of the little melonworm of described treatment Ctenopharyngodon idellus comprises 9 taste Chinese herbal medicine, described 9 taste Chinese herbal medicine ratios are Herba Artemisiae Annuae: Rhizoma Osmundae: the Radix Stemonae: Herba Schizonepetae: Caulis Perillae: Radix Sophorae Flavescentis: Pericarpium Citri Reticulatae: Cortex Phellodendri: Pericarpium Granati=18:15:21:10:8:6:8:11:7.

2. the manufacture method of the compound Chinese herb of the little melonworm for the treatment of Ctenopharyngodon idellus according to claim 1, is characterized in that: it comprises following concrete steps:

(1) decoct and extract for the first time: first multifunctional extracting pot cleanout door is closed, extraction pot top dog-house is opened, in proportion 9 taste Chinese herbal medicine are dropped in extraction pot, open extraction pot inlet valve, to the drinking water that is metered into 8 times of amounts of middle dose in extraction pot, close inlet valve and dog-house, open steam valve, be heated to 40 ℃, warm macerating, after 30 minutes, continues to be heated to boiling, in decoction process, observe at any time steam gage, thermometer and extraction pot Pressure gauge numerical value, and recording start boiling time, temperature, now jacket steam pressure keeps 0.02Mpa, decoct temperature and be controlled at 100 ℃ of left and right, in tank, keep fluidized state, decoct 2 hours, decoction process should constantly be observed decoction situation from visor, adjust at any time steam pressure, after decocting 2 hours, steam off valve, open the fluid valve of extraction pot, decocting liquid is crossed to 200 order filters, squeeze in fluid reservoir, drawing liquid is complete, on fluid reservoir, hang Status Flag, indicate decoction liquor title, lot number, quantity, date, operator etc.,

(2) decoct for the second time: open extraction pot inlet valve, be metered into 6 times of amount drinking waters, open steam valve and repeat the above operation that decocts, decocting liquid is crossed to 200 order filters after decocting 2 hours, squeeze in fluid reservoir, medicinal liquid total amount must not be lower than 3500L, and operating process has special messenger to carry out process monitoring, and makes a record;

(3) economic benefits and social benefits are concentrated: first by the vacuum of dual-effect concentrator, cooling water valve is opened, by medicinal liquid suction dual-effect concentrator, open steam valve and carry out concentrating under reduced pressure, evaporating temperature: an effect 75-85 ℃, two effect 60-70 ℃, vacuum: effect-0.03～-0.04Mpa, two effect-0.06～-0.07Mpa, in concentration process, to notice at any time that each table numerical control is in safety range, and perform record, concentrate while closely end, open the feed opening graduated cylinder of heater and collect concentrated solution, with gravity Baume instrumentation proportion, as inadequate in proportion, should continue to concentrate, until concentrated solution relative density reaches at 1.05 o'clock, get final product 60 ℃ of surveys, close vacuum valve, steam valve and cooling water valve, open the atmospheric valve of vaporization chamber, put cream,

(4) spraying is dry squeezes into concentrated solution in spray dryer and sprays and be dried, and obtains the former medicine of extract, adds carrier 20%, synergist 5% simultaneously.