CN107998276A - A kind of Changchun Bao oral liquid and preparation method thereof - Google Patents

A kind of Changchun Bao oral liquid and preparation method thereof Download PDF

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Publication number
CN107998276A
CN107998276A CN201810088157.2A CN201810088157A CN107998276A CN 107998276 A CN107998276 A CN 107998276A CN 201810088157 A CN201810088157 A CN 201810088157A CN 107998276 A CN107998276 A CN 107998276A
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China
Prior art keywords
parts
liquid
extraction
changchun
oral liquid
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CN201810088157.2A
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Chinese (zh)
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肖东
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CHONGQING RUEPEAK PHARMACEUTICAL Co Ltd
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CHONGQING RUEPEAK PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

Present invention mainly discloses a kind of Changchun Bao oral liquid, it is made of the raw material of following parts by weight：15 parts of ginseng, 10 parts of the fruit of Chinese wolfberry, 8 parts of Chinese yam, 5 parts of Schisandra chinensis, 4 parts of asparagus fern, 2 parts of ophiopogon, 6 parts of glutinous rehmannia, 10 parts of the fleece-flower root, 5 parts of Poria cocos, 3 parts of the root of bidentate achyranthes, 5 parts of Angelica sinensis, 4 parts of psoralea corylifolia, 3 parts of the bark of eucommia, 6 parts of Morinda officinalis, 5 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 5 parts of thizoma curculiginis, 10 parts of Herba Epimedii, 3 parts of rhizoma alismatis, 7 parts of Radix Salviae Miltiorrhizae, 12 parts of radix astragali, 4 parts of Ramulus Taxilli, 3 parts of the fruit of glossy privet, 8 parts of eclipta, the present invention is extracted by water-boiling method, ultrasonic extraction is respectively to being dissolved in water and the preferable medicinal material of thermostabilization and case of thermal instability, the facile hydrolysis or medicinal material of oxidation are effectively extracted.

Description

A kind of Changchun Bao oral liquid and preparation method thereof
Technical field：
The present invention relates to a kind of oral liquid field, more particularly to a kind of Changchun Bao oral liquid and preparation method thereof, belongs to doctor Medicine field.
Background technology：
Oral solutions is based on traditional Chinese herbal decoction, extracts active ingredient in medicine, and it is additional to add flavouring, bacteriostatic agent etc. Agent, and press injection ampoule encapsulation treatment process, manufactured a kind of sterile or half sterile oral liquid, therefore also known as mouth Take ampulla.It is a kind of new formulation that three kinds of decoction, syrup and injection formulations are combined.As SHENGMAI YIN KOUFUYE, Sini Tang oral liquid, ginseng antler royal jelly oral liquid etc..Its main feature is that taking dose is small, it is delicious, absorb it is fast, prove effective it is rapid, easily Received by patient.
The content of the invention：
The purpose of the present invention is in place of overcome the deficiencies in the prior art, there is provided a kind of Changchun Bao oral liquid and its preparation side Method, in poor health caused by liver-kidney deficiency, metal fatigue is had a dizzy spell, forgetful insomnia, deficiency of QI with disinclination to talk, and aversion to cold and cold limbs is indigestion and loss of appetite Deficiency of food, palpitaition is uncomfortable in chest, lassitude in loin and legs, dim eyesight tinnitus, shortness of breath, edema, and the disease such as many nights many urine has the effect of good, can also be used as height The adjuvant therapy medicaments of the hypertensive patient of pionemia, the present invention is with preparation process is simple, easy to use, curative effect is high, cost The characteristics of low.Solve the problems of the prior art.
To achieve the above object, the present invention provides following technical solution：A kind of Changchun Bao oral liquid and preparation method thereof, by The raw material composition of following parts by weight：15 parts of ginseng, 10 parts of the fruit of Chinese wolfberry, 8 parts of Chinese yam, 5 parts of Schisandra chinensis, 4 parts of asparagus fern, 2 parts of ophiopogon, Yellow 6 parts, 10 parts of the fleece-flower root, 5 parts of Poria cocos, 3 parts of the root of bidentate achyranthes, 5 parts of Angelica sinensis, 4 parts of psoralea corylifolia, 3 parts of the bark of eucommia, 6 parts of Morinda officinalis, 5 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 5 parts of thizoma curculiginis, 10 parts of Herba Epimedii, 3 parts of rhizoma alismatis, 7 parts of Radix Salviae Miltiorrhizae, 12 parts of radix astragali, 4 parts of Ramulus Taxilli, 3 parts of the fruit of glossy privet, ink drought 8 parts of lotus.
This hair Changchun Bao oral liquid and preparation method thereof, its preparation method includes the following steps：
Step 1：Water-boiling method extracts extracting solution
(1) boiling is extracted：It will be posted without 4 parts of asparagus fern going mouldy, 2 parts of ophiopogon, 6 parts of glutinous rehmannia, 5 parts of Poria cocos, 6 parts of Morinda officinalis, mulberry Put into after the fully drying of 4 parts raw, 4 parts of psoralea corylifolia, 3 parts of the fruit of glossy privet, 10 parts of excessive sheep capsule, 8 parts of eclipta in extractor, to extraction The distilled water that 10-15 times of parts by weight of medicine gross weight are added in tank carries out heating and boils to carry；
(2) leach cooking liquid concentrates：It is concentrated under reduced pressure to leach cooking liquid, thickening temperature is 60-65 DEG C, steam pressure 0.05- 0.08Mpa, vacuum 0.06-0.08Mpa, control relative density of medicine liquid form leach cooking liquid concentrate 1.10~1.15；
(3) adsorb, centrifuge：By liquid concentrate by resin column, it is eluted with water, whole eluents depressurize dense Contracting, thickening temperature are 60-65 DEG C, steam pressure 0.05-0.08Mpa, vacuum 0.06-0.08Mpa, and control liquid is opposite Density is 1.20~1.30, liquid concentrate；Concentrate is centrifuged using tube centrifuge, rotating speed is 3000-8000 revs/min Clock, centrifugate is concentrated under reduced pressure into relatively close 1.20~1.30, condensed cream A is loaded clean container sealing, in 2-8 DEG C of storage Deposit；
Step 2：Ultrasonic extraction extracting solution
(1) base extraction：Take 15 parts of ginseng, 10 parts of the fruit of Chinese wolfberry, 8 parts of Chinese yam, 5 parts of Schisandra chinensis, 10 parts of the fleece-flower root, Angelica sinensis 5 Part, 3 parts of the bark of eucommia, 5 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 5 parts of thizoma curculiginis, 3 parts of rhizoma alismatis, 7 parts of Radix Salviae Miltiorrhizae, 12 parts of radix astragali are put into pulverizer and are ground into It is uniformly mixed, is put into sterile chamber after coarse powder, the ph values for adding medicine 10 times of parts by weight of gross weight is 11 calcium hydroxide solutions, hydrogen Calcium oxide solution liquid level will not have a drug powder, when immersion 24 is small under normal temperature state；
(2) ultrasonic extraction：Medicinal powder after (1) base extraction is put into ultrasonic extraction instrument and is extracted, addition extraction is molten Extracted 3 times after agent, it is 40-45 DEG C, 46-50 DEG C, 51-55 DEG C, 56-60 DEG C to control temperature gradient, and extraction time is followed successively by 20min, 30min, 40min, ultrasonic power are followed successively by 200W, 300W, 400W, and Extraction solvent additive amount and medicinal powder gross weight ratio are 1：20, rough liquid is made after extraction；
(3) adsorb, centrifuge：By rough liquid by resin column, it is colourless and be in neutrality to be eluted to liquid with distilled water, will be complete Portion's eluent is concentrated under reduced pressure, and thickening temperature is 60-65 DEG C, steam pressure 0.05-0.08Mpa, vacuum 0.06- 0.08Mpa, control relative density of medicine liquid is 1.20~1.30, liquid concentrate；Concentrate is centrifuged using tube centrifuge, is turned Speed is 3000-8000 revs/min, centrifugate is concentrated under reduced pressure into relatively close 1.20~1.30, and condensed cream B is loaded clean hold Device seals, in 2-8 DEG C of storage；
Step 3：Prepare Changchun Bao oral liquid
Weigh after condensed cream A and condensed cream B is mixed evenly and be put into Agitation Tank, add 2 times of amounts of condensed cream weight Purified water is heated to seething with excitement, and stirs 15 minutes, and micro-boiling keeps the temperature 15 minutes and forms liquid；Uniform liquid to be mixed is placed into room Wen Hou, is driven into freezer fluid reservoir with infusion pump, under the conditions of 0~5 DEG C refrigeration 72 it is small when more than, carried out using centrifuge Filter, filtrate is transported in total Agitation Tank and is circulated 15 minutes；Oral liquid of the present invention is made.
Preferably, the resin column uses any one in 110, D151, D152, D113, D301,717 models to fill out Fill the resin column of thing.
Preferably, the Extraction solvent is appointing in methanol, n-butanol, absolute ethyl alcohol, glacial acetic acid, ethyl acetate, chloroform Meaning is a kind of.
Beneficial effects of the present invention：
It is a primary object of the present invention to carry Chinese medicine nursery soil formula and preparation method thereof, production technology of the invention will Ask higher, technique is fine.Repeatedly boil and carry, ensure that liquid extraction is complete, and carry out resin separation, remain with more preferable drug effect Active ingredient, liquid purity is high, therapeutic effect is notable.Using techniques such as heat treatment, resin adsorption, centrifugation, refrigerations, filter and remove Decontamination, ensure that liquid clarity.Absorption, centrifuge and more save the time than existing aqueous extraction-alcohol precipitation technology, existing water extracting alcohol Heavy process needs the time of 2 days, and absorption of the invention, 6 hours of centrifugal method or so can be completed to extract, and substantially increase work Make efficiency.Absorption, centrifugation removal of impurities are more thorough, and the impurity in liquid is more accurately removed using equipment such as centrifuge, resin columns, is made Liquid purity is more preferable.
4th, embodiment：
Technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only Part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art All other embodiments obtained without making creative work, belong to the scope of protection of the invention.
Embodiment：A kind of Changchun Bao oral liquid and preparation method thereof, is made of the raw material of following parts by weight：15 parts of ginseng, 10 parts of the fruit of Chinese wolfberry, 8 parts of Chinese yam, 5 parts of Schisandra chinensis, 4 parts of asparagus fern, 2 parts of ophiopogon, 6 parts of glutinous rehmannia, 10 parts of the fleece-flower root, 5 parts of Poria cocos, the root of bidentate achyranthes 3 Part, 5 parts of Angelica sinensis, 4 parts of psoralea corylifolia, 3 parts of the bark of eucommia, 6 parts of Morinda officinalis, 5 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 5 parts of thizoma curculiginis, 10 parts of Herba Epimedii, pool Rush down 3 parts, 7 parts of Radix Salviae Miltiorrhizae, 12 parts of radix astragali, 4 parts of Ramulus Taxilli, 3 parts of the fruit of glossy privet, 8 parts of eclipta.
This hair Changchun Bao oral liquid and preparation method thereof, its production method includes the following steps：
Step 1：Water-boiling method extracts extracting solution
(1) boiling is extracted：It will be posted without 4 parts of asparagus fern going mouldy, 2 parts of ophiopogon, 6 parts of glutinous rehmannia, 5 parts of Poria cocos, 6 parts of Morinda officinalis, mulberry Put into after the fully drying of 4 parts raw, 4 parts of psoralea corylifolia, 3 parts of the fruit of glossy privet, 10 parts of excessive sheep capsule, 8 parts of eclipta in extractor, to extraction The distilled water that 10-15 times of parts by weight of medicine gross weight are added in tank carries out heating and boils to carry；
(2) leach cooking liquid concentrates：It is concentrated under reduced pressure to leach cooking liquid, thickening temperature is 60-65 DEG C, steam pressure 0.05- 0.08Mpa, vacuum 0.06-0.08Mpa, control relative density of medicine liquid form leach cooking liquid concentrate 1.10~1.15；
(3) adsorb, centrifuge：By liquid concentrate by resin column, it is eluted with water, whole eluents depressurize dense Contracting, thickening temperature are 60-65 DEG C, steam pressure 0.05-0.08Mpa, vacuum 0.06-0.08Mpa, and control liquid is opposite Density is 1.20~1.30, liquid concentrate；Concentrate is centrifuged using tube centrifuge, rotating speed is 3000-8000 revs/min Clock, centrifugate is concentrated under reduced pressure into relatively close 1.20~1.30, condensed cream A is loaded clean container sealing, in 2-8 DEG C of storage Deposit；
Step 2：Ultrasonic extraction extracting solution
(1) base extraction：Take 15 parts of ginseng, 10 parts of the fruit of Chinese wolfberry, 8 parts of Chinese yam, 5 parts of Schisandra chinensis, 10 parts of the fleece-flower root, Angelica sinensis 5 Part, 3 parts of the bark of eucommia, 5 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 5 parts of thizoma curculiginis, 3 parts of rhizoma alismatis, 7 parts of Radix Salviae Miltiorrhizae, 12 parts of radix astragali are put into pulverizer and are ground into It is uniformly mixed, is put into sterile chamber after coarse powder, the ph values for adding medicine 10 times of parts by weight of gross weight is 11 calcium hydroxide solutions, hydrogen Calcium oxide solution liquid level will not have a drug powder, when immersion 24 is small under normal temperature state；
(2) ultrasonic extraction：Medicinal powder after (1) base extraction is put into ultrasonic extraction instrument and is extracted, addition extraction is molten Extracted 3 times after agent, it is 40-45 DEG C, 46-50 DEG C, 51-55 DEG C, 56-60 DEG C to control temperature gradient, and extraction time is followed successively by 20min, 30min, 40min, ultrasonic power are followed successively by 200W, 300W, 400W, and Extraction solvent additive amount and medicinal powder gross weight ratio are 1：20, rough liquid is made after extraction；
(3) adsorb, centrifuge：By rough liquid by resin column, it is colourless and be in neutrality to be eluted to liquid with distilled water, will be complete Portion's eluent is concentrated under reduced pressure, and thickening temperature is 60-65 DEG C, steam pressure 0.05-0.08Mpa, vacuum 0.06- 0.08Mpa, control relative density of medicine liquid is 1.20~1.30, liquid concentrate；Concentrate is centrifuged using tube centrifuge, is turned Speed is 3000-8000 revs/min, centrifugate is concentrated under reduced pressure into relatively close 1.20~1.30, and condensed cream B is loaded clean hold Device seals, in 2-8 DEG C of storage；
Step 3：Prepare Changchun Bao oral liquid
Weigh after condensed cream A and condensed cream B is mixed evenly and be put into Agitation Tank, add 2 times of amounts of condensed cream weight Purified water is heated to seething with excitement, and stirs 15 minutes, and micro-boiling keeps the temperature 15 minutes and forms liquid；Uniform liquid to be mixed is placed into room Wen Hou, is driven into freezer fluid reservoir with infusion pump, under the conditions of 0~5 DEG C refrigeration 72 it is small when more than, carried out using centrifuge Filter, filtrate is transported in total Agitation Tank and is circulated 15 minutes；Oral liquid of the present invention is made.
The basic principles, main features and the advantages of the invention have been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its Equivalent thereof.

Claims (4)

1. a kind of Changchun Bao oral liquid and preparation method thereof, it is characterised in that be made of the raw material of following parts by weight：Ginseng 15 Part, 10 parts of the fruit of Chinese wolfberry, 8 parts of Chinese yam, 5 parts of Schisandra chinensis, 4 parts of asparagus fern, 2 parts of ophiopogon, 6 parts of glutinous rehmannia, 10 parts of the fleece-flower root, 5 parts of Poria cocos, ox 3 parts of knee, 5 parts of Angelica sinensis, 4 parts of psoralea corylifolia, 3 parts of the bark of eucommia, 6 parts of Morinda officinalis, 5 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 5 parts of thizoma curculiginis, 10 parts of Herba Epimedii, 3 parts of rhizoma alismatis, 7 parts of Radix Salviae Miltiorrhizae, 12 parts of radix astragali, 4 parts of Ramulus Taxilli, 3 parts of the fruit of glossy privet, 8 parts of eclipta.
2. prepare Changchun Bao oral liquid described in claim 1 and preparation method thereof, it is characterised in that：The described method includes as follows Step：
Step 1：Water-boiling method extracts extracting solution
(1) boiling is extracted：By without go mouldy 4 parts of asparagus fern, 2 parts of ophiopogon, 6 parts of glutinous rehmannia, 5 parts of Poria cocos, 6 parts of Morinda officinalis, Ramulus Taxilli 4 Put into after the fully drying of part, 4 parts of psoralea corylifolia, 3 parts of the fruit of glossy privet, 10 parts of excessive sheep capsule, 8 parts of eclipta in extractor, to extractor The middle distilled water for adding 10-15 times of parts by weight of medicine gross weight carries out heating and boils to carry；
(2) leach cooking liquid concentrates：It is concentrated under reduced pressure to leach cooking liquid, thickening temperature is 60-65 DEG C, steam pressure 0.05- 0.08Mpa, vacuum 0.06-0.08Mpa, control relative density of medicine liquid form leach cooking liquid concentrate 1.10~1.15；
(3) adsorb, centrifuge：By liquid concentrate by resin column, it is eluted with water, whole eluents is concentrated under reduced pressure, it is dense Contracting temperature is 60-65 DEG C, steam pressure 0.05-0.08Mpa, vacuum 0.06-0.08Mpa, controls relative density of medicine liquid 1.20~1.30, liquid concentrate；Concentrate is centrifuged using tube centrifuge, rotating speed is 3000-8000 revs/min, will Centrifugate is concentrated under reduced pressure into relatively close 1.20~1.30, condensed cream A is loaded clean container sealing, in 2-8 DEG C of storage；
Step 2：Ultrasonic extraction extracting solution
(1) base extraction：Take 15 parts of ginseng, 10 parts of the fruit of Chinese wolfberry, 8 parts of Chinese yam, 5 parts of Schisandra chinensis, 10 parts of the fleece-flower root, 5 parts of Angelica sinensis, Du Secondary 3 parts, 5 parts of rhizoma anemarrhenae, 7 parts of Cortex Phellodendri, 5 parts of thizoma curculiginis, 3 parts of rhizoma alismatis, 7 parts of Radix Salviae Miltiorrhizae, 12 parts of radix astragali be put into pulverizer and be ground into coarse powder After be uniformly mixed, be put into sterile chamber, the ph values for adding medicine 10 times of parts by weight of gross weight are 11 calcium hydroxide solutions, hydroxide Calcium solution liquid level will not have a drug powder, when immersion 24 is small under normal temperature state；
(2) ultrasonic extraction：Medicinal powder after (1) base extraction is put into ultrasonic extraction instrument and is extracted, after adding Extraction solvent Extraction 3 times, control temperature gradient as 40-45 DEG C, 46-50 DEG C, 51-55 DEG C, 56-60 DEG C, extraction time be followed successively by 20min, 30min, 40min, ultrasonic power are followed successively by 200W, 300W, 400W, and Extraction solvent additive amount and medicinal powder gross weight ratio are 1：20, Rough liquid is made after extraction；
(3) adsorb, centrifuge：By rough liquid by resin column, it is colourless and be in neutrality to be eluted to liquid with distilled water, will all wash De- liquid is concentrated under reduced pressure, and thickening temperature is 60-65 DEG C, steam pressure 0.05-0.08Mpa, vacuum 0.06- 0.08Mpa, control relative density of medicine liquid is 1.20~1.30, liquid concentrate；Concentrate is centrifuged using tube centrifuge, is turned Speed is 3000-8000 revs/min, centrifugate is concentrated under reduced pressure into relatively close 1.20~1.30, and condensed cream B is loaded clean hold Device seals, in 2-8 DEG C of storage；
Step 3：Prepare Changchun Bao oral liquid
Weigh after condensed cream A and condensed cream B is mixed evenly and be put into Agitation Tank, add the purifying of 2 times of amounts of condensed cream weight Water is heated to seething with excitement, and stirs 15 minutes, and micro-boiling keeps the temperature 15 minutes and forms liquid；Uniform liquid to be mixed is placed into room temperature Afterwards, be driven into infusion pump in freezer fluid reservoir, under the conditions of 0~5 DEG C refrigeration 72 it is small when more than, carried out using centrifuge Filter, filtrate is transported in total Agitation Tank and is circulated 15 minutes；Oral liquid of the present invention is made.
A kind of 3. Changchun Bao oral liquid according to claim 2, it is characterised in that：The resin column is using 110, D151, In D152, D113, D301,717 models any one be filler resin column.
A kind of 4. Changchun Bao oral liquid according to claim 2, it is characterised in that：The Extraction solvent is methanol, positive fourth Any one in alcohol, absolute ethyl alcohol, glacial acetic acid, ethyl acetate, chloroform.
CN201810088157.2A 2018-01-30 2018-01-30 A kind of Changchun Bao oral liquid and preparation method thereof Pending CN107998276A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113908227A (en) * 2021-09-29 2022-01-11 苏州华葆药业股份有限公司 Oral liquid and preparation method thereof
CN115957282A (en) * 2022-12-29 2023-04-14 河北君临药业有限公司 Donkey-hide gelatin and astragalus oral liquid and preparation method thereof

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CN104189095A (en) * 2014-09-01 2014-12-10 门毅 Preparation process of oral liquid for treating cold

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113908227A (en) * 2021-09-29 2022-01-11 苏州华葆药业股份有限公司 Oral liquid and preparation method thereof
CN115957282A (en) * 2022-12-29 2023-04-14 河北君临药业有限公司 Donkey-hide gelatin and astragalus oral liquid and preparation method thereof
CN115957282B (en) * 2022-12-29 2024-03-26 河北君临药业有限公司 Donkey-hide gelatin astragalus oral liquid and preparation method thereof

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