CN107375468A - A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid and its preparation technology - Google Patents
A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid and its preparation technology Download PDFInfo
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Abstract
A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid of the present invention and its preparation technology, by formulations of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid prescription, materials procurement, raw material processing, raw material tcm and herbal slice extracts active ingredients, prepare it is canned, sterilize, the multiple working procedure such as pack and machine；Compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid prescription is formulated：5 kinds of 20 grams of the Radix Astragali, 20 grams of bighead atractylodes rhizome etc., honey and distillation water consumption, by 5: 5 volume measurements, preservative dosage 0.1%, the buying ratio of 75% alcohol solvent and tcm and herbal slice total amount is 2: 1；Raw material tcm and herbal slice extracts active ingredients, the patent of invention (July 3 2017 applying date) " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " designed using the applicant, applied carries out seepage pressure effects, extract solution adds auxiliary material to be mixed evenly, with 200 milliliters of volume oral liquid bottles carry out it is canned, pack, it is oral 20 milliliters every time, twice a day.
Description
Technical field
A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid of the present invention and its preparation technology category anti-tumor Chinese herbal preparation prepare neck
Domain, more particularly to a kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid and its preparation technology.
Background technology
Lung cancer is also one of common disease at present, it is known that long-term smoking, suction chemical substance, gas, environmental pollution etc. are
Its inducement, this sick non-evident sympton at initial stage, occur later on it is weak, become thin, shortness of breath, heating, silent, persistence cough, pectoralgia, phlegm
Middle band blood, made a definite diagnosis through X-ray chest-fluoroscopy, film making, disease inspection etc., histological type has squamous carcinoma, gland cancer, small cell carcinoma, large cell carcinoma, glandular scale
Cancer, class cancer and bronchial gland carcinoma, the cause of disease is unclear, and its traditional Chinese medical science differentiation of disease machine is six external factors which cause diseases exopathogen, and enemy intrusion or invasion is in lung, or the acute purulent lymphadenitis stasis of blood
Heresy, inside tie in lung, block mechanism of qi, declare respectful mistake department, lung arteries and veins stasis blocking, phlegm wet is not changed, and is tied in ecchymosis, positive gas consumption wound, and internal organs consume is cloudy
It is positive all to lose.The lung cancer course of disease is continuous, and lesion is complicated, and its dialectical feature is based on heresy Sheng, late period is based on weakened body resistance in early days.The traditional Chinese medical science with
Nourishing qi and blood, based on strengthening spleen, tonifying kidney, strengthening vital QI to eliminate pathogenic factors, tonification and purgation in combination.Combination operation if necessary, radiotherapy, chemotherapy, biological therapy are simultaneous
Apply.A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid of the present invention is based on Chinese medical discrimination, from the Radix Astragali, the bighead atractylodes rhizome, almond, Shi Shang
The taste tcm and herbal slice of cypress, psoralea corylifolia, honey etc. 6 is prepared into oral liquid, and treatment, health-care efficacy are played for many patients.
The content of the invention
The object of the present invention is to select 6 kinds of tcm and herbal slice groups such as the Radix Astragali, the bighead atractylodes rhizome, almond, selaginella doederlleini, psoralea corylifolia, honey
Into formula, a kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid is made, there is antitumor, reducing blood lipid, hypotensive, hypoglycemic, drop body
Weight, eliminating blood stasis and removing ecchymoses, strengthen the multiple functions such as immune.6 kinds of tcm and herbal slice effects are complementary, and effect is extensive, is often drunk by the course for the treatment of, then add
Upper necessary dietary adjustments and physical training, while psychological quality is adjusted, one surely makes lung neoplasm patient play treatment, health care work
With, mitigation patient mental's burden, raising patients ' life quality.
To achieve these goals, the technical solution adopted by the present invention is：A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid
Preparation technology is effective by the formulation of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid prescription, materials procurement, raw material processing, raw material
Constituents extraction, oral liquid are prepared, oral liquid filling sterilizes, label is pasted and packaging multiple working procedure machines；Compound astragalus membranaceus is white
Art anti-lung cancer oral liquid prescription is formulated：20 grams of the Radix Astragali, 20 grams of the bighead atractylodes rhizome, 5 grams of almond, 20 grams of selaginella doederlleini, 15 grams of psoralea corylifolia, honey with
It is equal to distill water consumption, by 5: 5 volume measurements, preservative dosage 0.1%, 75% alcohol solvent (removes honey with tcm and herbal slice
Similarly hereinafter) the buying ratio of total amount is 2: 1；Materials procurement：First determine that this batch of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid is always given birth to
Produce total bottle number, every bottle of capacity, production total capacity, every bottle take number of days, take total number of days, by take total number of days calculate it is every kind of in
The total expense of pharmaceutical decocting piece, graded kind are purchased, and the various tcm and herbal slices of buying have to comply with every kind of tcm and herbal slice
Quality index and specification standards, without go mouldy, it is no disease and pests harm, free from admixture, pollution-free；75% etoh solvent is purchased and tcm and herbal slice
Total amount buying ratio is 2: 1；Raw material are processed：In addition to honey, distilled water, preservative, every kind of tcm and herbal slice is carried out selected
And drying, after being sufficiently mixed uniformly, first crushed with 8 millimeters of particle diameter pulverizers, then it is standby with 4 millimeters of particle diameter pulverizers crushing；It is former
Material tcm and herbal slice extracts active ingredients, take ethanol extract from water precipitation to carry out, the patent of invention designed using the applicant, applied
(July 3 2017 applying date), " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " carried out diacolation
Extraction；The device is automatic by percolating extractor support, suit cylinder percolating device, electric pump circulatory displacement device, diacolation solution
Filter, temperature automatically controlled hot water circulating heating device, diacolation solvent evaporating separation device, diacolation solvent condensate recycling device seven
Part forms；The percolating extractor operation technological process is：Closing diacolation solution control valve 1.-→ opening charging closure-
- → layering that → meter feedstock is fitted into inner cylinder, which is fitted into uniform-→ the addition diacolation solvent of actual situation, drenches in circular groove-→ circular groove and is slowly added to
Diacolation solvent-→ solvent uniformly drench pushed down into raw material-→ circular groove not float-→ solvent adds to and no longer drenches into 5 lis away from circular groove bottom
Only circular hole in the middle part of closure is rotated to drenching and diacolation solution circulation pump-→ regulation diacolation solution is opened into circular groove inner edge-→ rice by-→
Circulating valve do not make diacolation solution overflow stop-→ close diacolation solution circulation pump-→ close charging closure penetrate screw tightening-→
Stand diacolation 36 hours-→ unlatching diacolation solution circulation pump circulatory displacement 36 hours-→ and close diacolation solution circulation pump-→ opening
Diacolation solution control valve-→ diacolation solution through the screen pack automatic fitration of internal barrel bottom-→ through diacolation solution control valve-→ inflow ooze
Solution evaporative cylinder top screen pack natural filtration-→ filtered fluid of filtering flows into diacolation solution evaporative cylinder bottom-→ and opens charging sealing
Lid-→ opens diacolation solution circulation pump-→ and determines whether internal barrel bottom screen pack filters and terminate that-→ 2. terminates filtering and close diacolation
Solution control valve-→ addition new diacolation solvent-→ progress secondary cycle seepage pressure effects (operating process is identical with first time)-→ bis-
- → opening diacolation solution control valve-→ secondary diacolation solution is automatic through internal barrel bottom screen pack after the completion of secondary circulatory displacement extraction
Filtering-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ secondary diacolation solution and flows into diacolation solution evaporative cylinder
Bottom-→ with the-secondary diacolation solution mixes and-→ 3. takes out inner cylinder and pour out dregs of a decoction cleaning-→ inner cylinder and be reentered into outer barrel-→ closing
Diacolation solution control valve-→ meter feedstock loads inner cylinder-→ and enters next seepage pressure effects program-→ secondary diacolation solution evaporative cylinder
Self-filtering net filtration, which terminates ,-→ 4. connect water source-→ to boiler, hot water storgae, condenser adds water-→ to open electromagnetic stove to heat
Heating water tanks-→ unlatching hot water circulating pump-→ boiler starts the cycle over-→ with hot water storgae hot water and added to diacolation solution evaporative cylinder
Heat-→ 5. opens automatic temperature control instrument-→ regulation temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature and rises to 90 DEG C
Electromagnetic stove closes automatically-→ hot water storgae water temperature be down to 80 DEG C of electromagnetic stove automatic opening-→ evaporative cylinder diacolation solution solvents evaporations-→
Solvent evaporate gas through gas delivery pipe-→ 6. gas be sent into condenser solvent gas merging chamber-→ solvent gas and enter condensation
Device spiral condensing tube be condensed into liquid-→ liquid into condenser condensing solvent collecting chamber-→ flow into condensing solvent recovery cylinder-
→ it is put into condensing solvent storage barrel-→ recycling or storage-→ the 7. total extraction in unlatching diacolation solution evaporative cylinder bottom valve-→
Medicine is put into the distilled water-→ that the storage barrel-heavy agitator addition of → heavy agitator-→ water of preparation water accounts for extraction medicine 60% and is slowly added to
Extraction medicine, which quickly stirs-→ and stirs to load precipitation cylinder-→ and be put into 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation, to be completed
Supernatant-→ is poured out to obtain compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer and always extract medicine.Compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid finished medicines are prepared；
After total extraction medicine is measured by volume, subtracted from oral liquid total capacity, residual volume amount, in 5: 5 ratio calculate honey with
Distilled water adds capacity, and preservative is calculated by 0.1% dosage；It is standby that stainless steel cylindrical vessel is risen with 300-400, it is total by what is measured
Extract medicine, honey, distilled water, preservative and add stainless steel cylindrical vessel, mixed, elder generation's stirring at low speed during stirring, no
Disconnected regulation is to high-speed stirred, until stirring.Compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid filling sterilization packaging：Will stirring
Uniform oral liquid finished product adds filling apparatus, carries out oral liquid bottling capping with 200 milliliters of volumetric flasks, obtains the compound astragalus membranaceus bighead atractylodes rhizome
Anti-lung cancer oral liquid finished product；Bottled oral liquid finished product is preserved into sale through high-temperature sterilization, adhesive label, mounted box vanning, storage.It is multiple
Square astragalus atractylodes anti-lung cancer oral liquid is taken：Oral 20 milliliters every time, 1 twice.
According to《Chinese book on Chinese herbal medicine》Record；The Radix Astragali is the dry root of legume astragalus mongolicus or Astragalus membranacus.Contain astragalin
I、II、IV.Soyasaponins I, calycosin, containing 2 ', 4 ' dihydroxy -5,6- dimethoxy isoflavones, choline, glycine betaine, ammonia
Base acid, sucrose, glucuronic acid and micro folic acid, sitosterol, linoleic acid and leukotrienes, asparagine, γ-aminobutyric acid,
Tens kinds of compositions such as astragalus polyose I, II, III, heteroglycan AH-1, AH-2, acidic polysaccharose AMon-S, its main anticancer component are
Astragalus polyose and astragalus injection；The bighead atractylodes rhizome is the rhizome of the feverfew bighead atractylodes rhizome.Containing volatile oil, inside there are α-and a β-Humuleno, β-
Elemol, α curcumenes, atractylone, 3 β-acetoxyl group atractylone, celery dienone, eucalyptol, palmitic acid, hinesol, β-celery
Sub- alkene [2] etc..Also compound containing sesquiterpene lactone：Atractyloide-I ,-II ,-III and 8 β-ethyoxyl atractyloide-II.Contain again
Polyacetylene compound：The cis reefing triols of 14- acetyl group -12- climbing groundsel acyl groups -8-, each inner smooth acyl group -8- of 14- acetyl group are anti-
Formula bighead atractylodes rhizome triol etc..Separately contain Scopoletin, fructose, synanthrin, have immunocompetent mannosan AM-3 [6], and aspartic acid,
Serine, glutamic acid, alanine, glycine, valine, isoleucine, leucine, tyrosine, phenylalanine, lysine, group
The amino acid such as propylhomoserin, arginine, proline.Almond is rosaceous plant apricot, wild apricot, ansu apricot, the seed of prunus mandshuricaKoehne.Contain bitter taste
Cyanogen glucoside：Amygdalin about 4% and prunasin；Fat oil about 50%, there are 8 kinds of aliphatic acid in oily, important is linoleic acid to account for 27%,
Oleic acid account for 67% and palmitic acid account for 5.2%.It is 5 '-caffeoylquinic acids also containing chlorogenic acid, neochlorogenic acid is 3 '-caffeoyl
Quininic acid, 3 '-feruloylquinic acid, 5 '-feruloylquinic acid, 3 '-to coumaric acyl quininic acid, inositol, stigmasterol, β-paddy steroid
Alcohol, Δ 5- avenasterols, cholesterine 24- cholestenols, Estrone, 17 beta estradiols, glycerol trioleate.Separately contain anti-inflammatory
With 2 kinds of protein components of analgesic activities：KR-A and KR-B, its content are respectively 4.44% and 0.41%.Contain again fragrant with almond
The relevant volatile ingredient of taste：This formaldehyde, linalool, 4- terpinenols, alpha-terpineol.Selaginella doederlleini is the dark green volume of Spikemoss plant
The herb of cypress.Containing hordenine-O- α-L- rhamnopyranosyloxyhy glucosides, N- methyltyramine-O- α-L- rhamnopyranosyloxyhy glucosides, (E)-big
Hordenine-(6-O- cinnamoyl-β-D- glucopyranosyls)-(1 → 3)-α-L- rhamnopyranosyloxyhy glucosides, (E)-hordenine-[6-
O- (4- hydroxycinnamoyls)-β-D- glucopyranosyls]-(1 → 3)-α-L- rhamnopyranosyloxyhy glucosides etc.；Psoralea corylifolia is legume
The fruit of psoralea corylifolia.Contain the composition such as Coumarins, flavonoids, monoterpene phenols and volatile oil, soap formula, polysaccharide, lipoid.Tonka-bean
Smart class has：Psoralen, Isopsoralen are root of Dahurain angelica element, and xanthotoxin is 8-methoxypsoralen, and psoralidine is different
Psoralidine, psoralea corylifolia furoeoumarin, 2 ', 3 '-epoxides of psoralidine, corylidin etc..Have in flavonoids：
Astragalin.Have in dioxygen flavonoids：Psoralea corylifolia flavanone is Coryfolin, the double reddish yellow ketone of different psoralea corylifolia, psoralea corylifolia
Flavanone methyl ether etc.；Have in chalcone：Corylifolinin is isobavachalcone etc.；Have in osajin：Psoralen
Fat isoflavones, neobavaisoflavone, cupreol-D-Glucose glucoside etc..Separately contain lipids, inside there is a glyceryl ester, two
Glyceride, monoglyceride, wax ester, hydrocarbon, polar lipid etc.；Also lipopolysaccharides containing Psoralen and-kind of a relative molecular mass is
55000th, the trypsin inhibitor containing 12 amino acid；Again containing members such as potassium, manganese, calcium, iron, copper, zinc, arsenic, antimony, rubidium, strontium, selenium
Element.Aliphatic acid in oil, mainly there are palmitic acid, oleic acid and linoleic acid, also stearic acid, leukotrienes and tetracosanoic acid.Honey is
The honey that the close honeybee of Apidae animal China or apis mellifera are made.Containing the glucide led in honeycomb, master contains grape
Sugar, fructose；Other also contain sucrose, dextrin, organic acid, protein, volatile oil, wax, pollen grain, vitamin B1, B2, B6, C, K,
H, amylase, turn people's enzyme, peroxidase, esterase, growth stimulant, acetylcholine, nicotinic acid, pantothenic acid, carrotene, inorganic elements
Calcium, sulphur, phosphorus, magnesium, potassium, sodium, iodine etc..
The beneficial effects of the invention are as follows：Above-mentioned 6 kinds of Chinese medicine prescriptions, the Radix Astragali have anticancer, anti-aging, antifatigue, disease-resistant
Poison, antibacterium, resisting stress, hypotensive, hypoglycemic, a variety of effects such as promote cell metabolism, protection liver kidney, enhancing immune, it is led
It is astragalus polyose and astragalus injection to want anticancer component；Its anticancer component of the bighead atractylodes rhizome is mainly volatile oil；With antitumor action, resist
Hemoglutination, hypoglycemic effect, promote hematopoiesis function, promote protein synthesis, strong effect, sedation, antibacterial action etc.；
Its main anticancer component of semen armeniacae amarae is Semen Armeniacae Amarum extract；With antitumaous effect, hypotensive activity, antitussive and antiasthmatic effect, anti-inflammatory
Analgesic activity etc.；Its main anticancer component of selaginella doederlleini is selaginella doederlleini extract solution, has anticancer, antipyretic and antidote functions.For fine hair
Film epithelioma, lung cancer, throat cancer and alimentary tract cancer etc.；Its main anticancer component of psoralea corylifolia is psoralen and selenium element etc.；
With antitumor action, psoralea corylifolia has the function that cardiac stimulant and coronary artery dilator, increase coronary blood flow, and psoralea corylifolia has promotion
The effect of skin pigment hyperplasia, psoralea corylifolia have suppression and killing action, psoralea corylifolia to significantly increase immunity of organism to various kinds of cell
The effect of function, the airway constriction that psoralea corylifolia is introduced to histamine have obvious diastole to act on, and psoralea corylifolia has obvious insecticidal action, mend
Bone fat has anti-aging effects；Honey has lipotropy, can improve the composition of blood, promotes heart and brain and vascular function；It is right
Liver has protective effect, can promote liver cell regeneration；It can rapidly regain one's strength of body, dispelling fatigue, build up one's resistance to disease；Also
There is sterilizing；The skin damage of moderate can be treated, is particularly scalded；Sleep can be improved；It can also relax bowel；
6 kinds of tcm and herbal slices of the above have anticancer, reducing blood lipid, hypoglycemic, hypotensive, anti-fatty liver, the anti-ageing effect of waiting for a long time；Effect is mutual
To mend, effect is extensive, is often drunk by the course for the treatment of, along with necessary physical training, adjusts psychological quality ,-surely play anticancer, health care work
With, mitigation patient mental's burden, raising patients ' life quality.
Embodiment
Specific embodiment：
1st, formulating compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid prescription is：20 grams of the Radix Astragali, 20 grams of the bighead atractylodes rhizome, 5 grams of almond, selaginella doederlleini
20 grams, 15 grams of psoralea corylifolia, honey is equal with distillation water consumption, by 5: 5 volume measurements, preservative dosage 0.1%.
2nd, it is 1000 bottles to determine this batch compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid output, per bottled 200 milliliters, is needed altogether
Oral liquid total amount is prepared as 200 liters.
3rd, the tcm and herbal slice total amount as needed for this batch compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid output and recipe calculation
For 400 kilograms, calculating 5 kinds of tcm and herbal slice amount of purchases by formula rate is respectively：Radix Astragali double centner, bighead atractylodes rhizome double centner,
25 kilograms of almond, selaginella doederlleini double centner, 75 kilograms, the ratio of honey and distilled water is 5: 5, waits active ingredients from traditional Chinese medicinal to extract
After the completion of measure buying；Preservative dosage is 0.1%, and 75% alcohol solvent purchases 1000 liters, is recycled.
4th, compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid tcm and herbal slice is processed：Every kind of tcm and herbal slice is carried out selected and dried in the air
Shine, after being sufficiently mixed uniformly, first crushed with 6 millimeters of particle diameter pulverizers, then it is standby with 3 millimeters of particle diameter pulverizers crushing.
5th, compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid tcm and herbal slice extracts active ingredients：Ethanol extract from water precipitation is taken to carry out,
" cylinder is electronic follows for medicinal herb componentses suit for the patent of invention (July 3 2017 applying date) designed using the applicant, applied
Ring automatic fitration percolating extractor " carries out seepage pressure effects；The device is by percolating extractor support, suit cylinder diacolation dress
Put, electric pump circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent steam
Send out separator, the part of diacolation solvent condensate recycling device seven composition；The percolating extractor operation technological process is：1. close
Diacolation solution control valve-→ opens charging closure-→ meter feedstock loading inner cylinder-→ layering loading actual situation, and uniformly-→ adds
Diacolation solvent, which is drenched in circular groove-→ circular groove, to be slowly added to diacolation solvent-→ solvent and uniformly drenches push down circular groove into raw material-→ and not float
Rise-→ solvent add to no longer drench into 5 centimetres away from circular groove bottom only-→ by circular hole in the middle part of closure rotate to drench into circular groove inner edge-→
Opening diacolation solution circulation pump-→ regulation diacolation solution circulating valve does not make diacolation solution overflow only-→ closing diacolation solution circulation
Pump-→ closes charging closure and penetrates 36 hours-→ unlatching diacolation solution circulation pump circulatory displacements of screw tightening-→ standing diacolation
36 hours-→ close diacolation solution circulation pump-→ open diacolation solution control valve-→ diacolation solution through internal barrel bottom screen pack from
Dynamic filtering-→ through diacolation solution control valve ,-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ filtered fluid and flowed into
Open charging closure-→ and open diacolation solution circulation pump-→ and determine internal barrel bottom screen pack in diacolation solution evaporative cylinder bottom-→
Whether filtering, which terminates ,-→ is 2. terminated filtering and closes diacolation solution control valve-→ and add new diacolation solvent-→ and carry out secondary cycle to ooze
Filter opened after the completion of extraction (operating process with the-secondary identical)-→ secondary cycle seepage pressure effects-→ diacolation solution control valve-→
Secondary diacolation solution is through the screen pack automatic fitration of internal barrel bottom-→ flow into the top screen pack natural filtration of diacolation solution evaporative cylinder-
→ secondary diacolation solution flows into diacolation solution evaporative cylinder bottom-→ and-→ is mixed with first time diacolation solution 3. taking-up inner cylinder is poured out
Dregs of a decoction cleaning-→ inner cylinder is reentered into outer barrel-→ and closed under diacolation solution control valve-→ meter feedstock loading inner cylinder-→ entrance
Secondary seepage pressure effects program-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to hot water
Case, hot water storgae, condenser add water-→ to open electromagnetic stove to boiler heating-→ unlatching hot water circulating pump-→ boiler and hot water
Groove hot water starts the cycle over-→, and 5. opening automatic temperature control instrument-→ to diacolation solution evaporative cylinder heating-→ adjusts temperature controller high temperature to 90
DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature be down to 80 DEG C of electromagnetic stoves from
Dynamic unlatchings-→ evaporative cylinder diacolation solution solvent evaporation-→ solvent evaporation gas through gas delivery pipe-→ 6. gas feeding condenser
Solvent gas merging chamber-→ solvent gas into condenser spiral condensing tube be condensed into liquid-→ liquid into condenser it is cold
Solidifying solvent collecting chamber-→ flow into condensing solvent recovery cylinder-→ be put into condensing solvent storage barrel-→ recycle or storage-→ 7.
Open diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine and be put into storage barrel-→ heavy agitator of the heavy agitator-→ water of preparation water
Add account for extraction medicine 60% distilled water-→ be slowly added to extract medicine quickly stir-→ stir load precipitation cylinder-→ be put into
0--S DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion pour out supernatant-→ and obtain compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer and always extract medicine.
6th, compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid finished medicines are prepared：It is total from oral liquid after total extraction medicine is measured by volume
Subtracted in 200 liters of capacity, residual volume amount, calculate honey in 5: 5 ratio adds capacity with distilled water, and preservative is pressed
0.1% dosage calculates；It is standby that stainless steel cylindrical vessel, thick finished medicines, honey, distilled water, the anti-corrosion that will be measured are risen with 300-400
Agent adds stainless steel cylindrical vessel, is mixed, elder generation's stirring at low speed, constantly regulate to high-speed stirred during stirring, until filling
Divide and stir.
7th, compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid filling sterilization packaging：The oral liquid finished product to stir is added filling
Device, the bottling capping of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid is carried out with 200 milliliters of volumetric flasks；Obtain compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer
Oral liquid finished product；By bottled compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid finished product through high-temperature sterilization, adhesive label, mounted box vanning, enter
Storehouse preserves sale.
8th, compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid is taken：Oral 20 milliliters every time, 1 twice.
Claims (7)
1. compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid prescription is formulated, it is characterized in that：20 grams of the Radix Astragali, 20 grams of the bighead atractylodes rhizome, 5 grams of almond, stone
Upper 20 grams of cypress, 15 grams of psoralea corylifolia, honey and distillation water consumption, by 5: 5 volume measurements, preservative dosage 0.1%.
2. compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid materials procurement, it is characterized in that：First determine compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer mouth
Take liquid this batch always produce total bottle number, every bottle of capacity, production total capacity, every bottle take number of days, take total number of days, by taking total day
Number calculates the total expense of every kind of tcm and herbal slice, and graded kind is purchased, and the various tcm and herbal slices of buying have to comply with often
The quality index and specification standards of kind of tcm and herbal slice, without go mouldy, it is no disease and pests harm, free from admixture, pollution-free；75% etoh solvent is adopted
Purchase is 2: 1 with tcm and herbal slice total amount buying ratio.
3. compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid raw material are processed, it is characterized in that：In addition to honey, distilled water, preservative, to every
Kind of tcm and herbal slice is carried out selected and dried, and after being sufficiently mixed uniformly, is first crushed with 8 millimeters of particle diameter pulverizers, then with 4 millimeter particles
Footpath pulverizer crushes standby.
4. compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid tcm and herbal slice extracts active ingredients, it is characterized in that：Take ethanol extract from water precipitation
Carry out, patent of invention (July 3 2017 applying date) " the medicinal herb componentses suit cylinder electricity designed using the applicant, applied
Dynamic circulation automatic fitration percolating extractor " carries out seepage pressure effects；The device is by percolating extractor support, suit cylinder diacolation
Device, electric pump circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent
Evaporating separation device, the part of diacolation solvent condensate recycling device seven composition；The percolating extractor operation technological process is：1. close
Close diacolation solution control valve-→ open charging closure-→ meter feedstock load inner cylinder-→ layering load actual situation uniform-→ plus
Enter diacolation solvent and drench in circular groove-→ circular groove to be slowly added to diacolation solvent-→ solvent and uniformly drench into raw material-→ that pushing down circular groove should not
Float-→ solvent add to no longer drench into 5 centimetres away from circular groove bottom only-→ by circular hole in the middle part of closure rotate to drench into circular groove inner edge-
→ unlatching diacolation solution circulation pump-→ regulation diacolation solution circulating valve does not make diacolation solution spilling, and only-→ closing diacolation solution follows
Ring pump-→, which closes charging closure and penetrates screw tightening-→ and stand diacolation 36 hours-→ and open diacolation solution circulation pump and circulate, to be oozed
- → closing diacolation solution circulation pump-→ of filtering 36 hours opens diacolation solution control valve-→ diacolation solution through internal barrel bottom screen pack
Automatic fitration-→ through diacolation solution control valve-→ diacolation solution inflow evaporative cylinder top screen pack natural filtration-→ filtering liquid stream
Enter diacolation solution evaporative cylinder bottom-→ opening charging closure-→ unlatching diacolation solution circulation pump-→ and determine that internal barrel bottom is filtered
Whether net, which filters, which is terminated ,-→ 2. terminates filtering closing diacolation solution control valve-→ addition new diacolation solvent-→ progress secondary cycle
After the completion of seepage pressure effects (operating process with the-secondary identical)-→ secondary cycle seepage pressure effects-→ open diacolation solution control valve-
Through the screen pack automatic fitration of internal barrel bottom ,-→ flows into diacolation solution evaporative cylinder top screen pack nature mistake to → secondary diacolation solution
Filter-→ secondary diacolation solution flows into diacolation solution evaporative cylinder bottom-→ and-→ is mixed with first time diacolation solution 3. taking-up inner cylinder falls
Go out dregs of a decoction cleaning-→ inner cylinder and be reentered into outer barrel-→ closing diacolation solution control valve-→ meter feedstock loading inner cylinder-→ entrance
Next seepage pressure effects program-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to hot water
Case, hot water storgae, condenser add water-→ to open electromagnetic stove to boiler heating-→ unlatching hot water circulating pump-→ boiler and hot water
Groove hot water starts the cycle over-→, and 5. opening automatic temperature control instrument-→ to diacolation solution evaporative cylinder heating-→ adjusts temperature controller high temperature to 90
DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature be down to 80 DEG C of electromagnetic stoves from
Dynamic unlatchings-→ evaporative cylinder diacolation solution solvent evaporation-→ solvent evaporation gas through gas delivery pipe-→ 6. gas feeding condenser
Solvent gas merging chamber-→ solvent gas into condenser spiral condensing tube be condensed into liquid-→ liquid into condenser it is cold
Solidifying solvent collecting chamber-→ flow into condensing solvent recovery cylinder-→ be put into condensing solvent storage barrel-→ recycle or storage-→ 7.
Open diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine and be put into storage barrel-→ heavy agitator of the heavy agitator-→ water of preparation water
Add account for extraction medicine 60% distilled water-→ be slowly added to extract medicine quickly stir-→ stir load precipitation cylinder-→ be put into
Supernatant-→ is poured out in 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion, and it is total to obtain compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid
Extract medicine.
5. compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid finished medicines are prepared；It is characterized in that：After total extraction medicine is measured by volume, from oral
Subtracted in 200 liters of liquid total measurement (volume) amount, residual volume amount, calculate honey and distillation water capacity in 5: 5 ratio, preservative is pressed
0.1% dosage calculates；It is standby that stainless steel cylindrical vessel is risen with 300-400, by the total extraction medicine measured, honey, distilled water, anti-corrosion
Agent adds stainless steel cylindrical vessel, is mixed, elder generation's stirring at low speed, constantly regulate to high-speed stirred during stirring, until filling
Divide and stir.
6. compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid filling sterilization packaging；It is characterized in that：The oral liquid finished product to stir is added
Enter filling apparatus, oral liquid bottling capping is carried out with 200 milliliters of volumetric flasks；Obtain compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid finished product；
Bottled oral liquid finished product is preserved into sale through high-temperature sterilization, adhesive label, mounted box vanning, storage.
7. compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid is taken：It is characterized in that；Oral 20 milliliters every time, 1 twice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710651491.XA CN107375468A (en) | 2017-07-25 | 2017-07-25 | A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid and its preparation technology |
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| CN201710651491.XA CN107375468A (en) | 2017-07-25 | 2017-07-25 | A kind of compound astragalus membranaceus bighead atractylodes rhizome anti-lung cancer oral liquid and its preparation technology |
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| CN107375468A true CN107375468A (en) | 2017-11-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451480A (en) * | 2020-12-14 | 2021-03-09 | 济南深蓝动物保健品有限公司 | Method for extracting astragalus polysaccharide oral liquid |
-
2017
- 2017-07-25 CN CN201710651491.XA patent/CN107375468A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451480A (en) * | 2020-12-14 | 2021-03-09 | 济南深蓝动物保健品有限公司 | Method for extracting astragalus polysaccharide oral liquid |
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