CN104524458A - 一种治疗肝胆结石的中药散剂及其制备方法 - Google Patents
一种治疗肝胆结石的中药散剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗肝胆结石的中药散剂及其制备方法,由下述重量份数的药材制成:金钱草31-49份,茵陈25-40份,独角莲20-36份,金银花16-30份,姜黄11-26份,香附9-18份,青皮3-10份,大黄8-14份,白豆蔻2-8份,砂仁3-7份,厚朴1-6份。本发明配方合理,服用方便安全,未发现毒副作用,临床验证疗效确切、显著。多年临床观察表明,本药具有养阴柔肝,滋阴降火,消炎利胆排石功能,治疗肝阴不足,湿热内蕴之胆囊结石、肝内胆管结石的有效率高达90%以上。
Description
技术领域
本发明涉及一种治疗肝胆结石的中药散剂。属于医药技术领域。
背景技术
肝、胆结石属于中医“肋瘤”“腹痛”“胃痛”等病之范畴。病因病机多为肝气郁结、肝失调达,胆附于肝,胆失疏泄、气滞血瘀、湿热阻滞、蕴结石化、煎熬成结石,停滞胆道,肝胆气机不化,故而为患。
胆石症是临床常见病,多发病,近年来胆石症患者更是逐年递增。目前临床常用的治疗肝胆结石的方案包括西医手术、碎石治疗以及中成药口服治疗等。手术治疗肝胆结石的一大弊端就是术后结石的残余及复发。碎石治疗只适用于胆囊小结石,治愈不彻底,易复发;胆管切除术对患者造成的痛苦大,并且费用高,不适合工薪阶层患者。目前市面上治疗肝胆结石的中成药又良莠不齐,溶石排石效果差,对于减少术后残石率,预防结石复发更是效果不佳。
发明内容
本发明所要解决的技术问题是:提供一种对肝胆结石行之有效的、价格低,治疗效果好且不复发的的中药散剂,同时还提供一种其制备方法。
为解决上述技术问题,本发明采用的技术方案是:
本发明提供的治疗肝胆结石的中药散剂,所述中药散剂由下述重量份数的药材制成:金钱草31-49份,茵陈25-40份,独角莲20-36份,金银花16-30份,姜黄11-26份,香附9-18份,青皮3-10份,大黄8-14份,白豆蔻2-8份,砂仁3-7份,厚朴1-6份。
优选的,所述的中药散剂由下述重量份数的药材制成:金钱草36份,茵陈33份,独角莲28份,金银花21份,姜黄19份,香附11份,青皮7份,大黄11份,白豆蔻6份,砂仁5份,厚朴3份。
优选的,所述的中药散剂由下述重量份数的药材制成:金钱草40份,茵陈36份,独角莲30份,金银花25份,姜黄15份,香附14份,青皮9份,大黄13份,白豆蔻7份,砂仁6份,厚朴5份。
本发明还提供了制备上述中药散剂的方法,包括下列步骤:
(1)按照重量配比金钱草、茵陈、独角莲、金银花、姜黄、香附、青皮,加入重量为药材总重量6-11倍的水,65-70摄氏度浸泡18-25个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态30-45分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)2-8次,合并所得的药液,将药液浓缩成60℃下相对密度为1.15~1.25的稠膏;
(4)将大黄、白豆蔻、砂仁、厚朴研磨成500-800目的细粉末;
(5)将步骤(3)的稠膏、步骤(4)的药物细粉末混合,搅拌混着均匀,烘干制成颗粒剂。
优选的,步骤(1)浸泡之前将药材研磨600-900目的粉末。
本发明提供了一种步骤(2)中的水温梯度升高到沸腾的方式,具体是:水温每4-8分钟升高10摄氏度,并且每升高10摄氏度保持15分钟。
本发明的中药颗粒剂的服用方法:每日三次,每次6-10克,饭后温开水送服。
本发明的有益效果:
本发明配方合理,服用方便安全,未发现毒副作用,临床验证疗效确切、显著。多年临床观察表明,本药具有养阴柔肝,滋阴降火,消炎利胆排石功能,治疗肝阴不足,湿热内蕴之胆囊结石、肝内胆管结石的有效率高达90%以上,同时本药还可以用于减少术后残石率,预防结石复发,针对术前调理及术后巩固,效果显著。而且本发明的中药制备成本低,治愈后不复发,解除了广大患者的痛苦,产生了良好的经济效益和社会效益。
1)与当前治疗的化学治疗药物相比,本发明中药散剂为天然纯中药散剂,不良反应和副作用显著降低,且本发明中药散剂作用全面,药物治疗效果更佳,并提高了患者的生活质量。
2)本发明中药散剂中含有多种药物组分,作用靶点众多,药理实验显示其与现有的胆结石治疗药物在溶石方面具有显著的协同作用,并且可以大幅度减少药物治疗引发的便秘症状,提高病人对于化疗的接受度和用药依从性。
具体实施方式
实施例1
本实施例的中药散剂由下述重量克数的药材制成:金钱草36克,茵陈33克,独角莲28克,金银花21克,姜黄19克,香附11克,青皮7克,大黄11克,白豆蔻6克,砂仁5克,厚朴3克。
制备上述中药散剂的方法,包括下列步骤:
(1)按照重量配比金钱草、茵陈、独角莲、金银花、姜黄、香附、青皮,加入重量为药材总重量8倍的水,68摄氏度浸泡21个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态37分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)5次,合并所得的药液,将药液浓缩成60℃下相对密度为1.19的稠膏;
(4)将大黄、白豆蔻、砂仁、厚朴研磨成600目的细粉末;
(5)将步骤(3)的稠膏、步骤(4)的药物细粉末混合,搅拌混着均匀,烘干制成颗粒剂。
步骤(1)浸泡之前将药材研磨800目的粉末。
步骤(2)中的水温梯度升高到沸腾的方式,具体是:水温每6分钟升高10摄氏度,并且每升高10摄氏度保持15分钟。
中药颗粒剂的服用方法:每日三次,每次8克,饭后温开水送服。
实施例2
本实施例的中药散剂由下述重量克数的药材制成:金钱草40克,茵陈36克,独角莲30克,金银花25克,姜黄15克,香附14克,青皮9克,大黄13克,白豆蔻7克,砂仁6克,厚朴5克。
制备上述中药散剂的方法,包括下列步骤:
(1)按照重量配比金钱草、茵陈、独角莲、金银花、姜黄、香附、青皮,加入重量为药材总重量10倍的水,69摄氏度浸泡20个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态40分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)7次,合并所得的药液,将药液浓缩成60℃下相对密度为1.20的稠膏;
(4)将大黄、白豆蔻、砂仁、厚朴研磨成700目的细粉末;
(5)将步骤(3)的稠膏、步骤(4)的药物细粉末混合,搅拌混着均匀,烘干制成颗粒剂。
步骤(1)浸泡之前将药材研磨700目的粉末。
步骤(2)中的水温梯度升高到沸腾的方式,具体是:水温每7分钟升高10摄氏度,并且每升高10摄氏度保持15分钟。
中药颗粒剂的服用方法:每日三次,每次7克,饭后温开水送服。
实施例3
本实施例的中药散剂由下述重量克数的药材制成:
金钱草49克,茵陈40克,独角莲36克,金银花30克,姜黄26克,香附18克,青皮10克,大黄14克,白豆蔻8克,砂仁7克,厚朴6克。
制备上述中药散剂的方法,包括下列步骤:
(1)按照重量配比金钱草、茵陈、独角莲、金银花、姜黄、香附、青皮,加入重量为药材总重量11倍的水,70摄氏度浸泡25个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态45分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)8次,合并所得的药液,将药液浓缩成60℃下相对密度为1.25的稠膏;
(4)将大黄、白豆蔻、砂仁、厚朴研磨成800目的细粉末;
(5)将步骤(3)的稠膏、步骤(4)的药物细粉末混合,搅拌混着均匀,烘干制成颗粒剂。
步骤(1)浸泡之前将药材研磨900目的粉末。
步骤(2)中的水温梯度升高到沸腾的方式,具体是:水温每8分钟升高10摄氏度,并且每升高10摄氏度保持15分钟。
中药颗粒剂的服用方法:每日三次,每次6克,饭后温开水送服。
实施例4
本实施例的中药散剂由下述重量克数的药材制成:金钱草31克,茵陈25克,独角莲20克,金银花16克,姜黄11克,香附9克,青皮3克,大黄8克,白豆蔻2克,砂仁3克,厚朴1克。
制备上述中药散剂的方法,包括下列步骤:
(1)按照重量配比金钱草、茵陈、独角莲、金银花、姜黄、香附、青皮,加入重量为药材总重量6倍的水,65摄氏度浸泡18个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态30分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)4次,合并所得的药液,将药液浓缩成60℃下相对密度为1.15的稠膏;
(4)将大黄、白豆蔻、砂仁、厚朴研磨成500目的细粉末;
(5)将步骤(3)的稠膏、步骤(4)的药物细粉末混合,搅拌混着均匀,烘干制成颗粒剂。
步骤(1)浸泡之前将药材研磨600目的粉末。
步骤(2)中的水温梯度升高到沸腾的方式,具体是:水温每4分钟升高10摄氏度,并且每升高10摄氏度保持15分钟。
中药颗粒剂的服用方法:每日三次,每次7克,饭后温开水送服。
实施例5 临床试验
选取370例门诊和住院患者进行临床试验,这些患者依据临床症状体征,辅以超声、腹平片、实验室检查确诊为肝胆结石。年龄最大69岁,最小者15岁,病程最长者13年,最短1周,胆囊结石420例,单纯肝内胆管结石83例,肝内外胆管结石57例,结石最大5.2*2.6cm,最小0.4*0.3cm。
服用实施例1制得的药对上述患者进行临床试验,每次服用8g,日三次口服,一个月为一个疗程,三个疗程后检查患者病状。
判断标准为:
治愈:症状、体征消失,实验室,影像学检查结石消失。
有效:症状、体征减轻,实验室,影像学检查结石较前减少或变小。
无效:症状、体征减轻不明显,影像学检查结石体积数量无变化。
实验结果显示:治愈患者315例,占总人数85.1%;有效患者39例,占总人数10.5%;无效患者16例,占总人数4.3%,实施例1的总有效率95.7%,证明本发明对肝胆结石具有明显的治疗效果。
实施例6 典型病例
1.张某,男,71岁,慢性胆囊炎,常服用消炎利胆片,维持病情。服用本发明实施例1的药物治疗,每天3次,每次8克,5天后症状好转,能少量饮食,不再呕吐,疼痛缓解,呕吐物无血,无黑便,继服用本药,巩固治疗1个月后,饮食基本正常,B超显示结石缩小病为0.8×0.7cm大小,又巩固2个月后病症消失,1个月后复诊B超未见胆囊内有结石探及,随后又加服1个疗程,随诊2年未见异常,身体健康。 2、李某,女,45岁,有冠心病史,平时饮食不佳,时有右上腹阵发性疼痛,胸闷满胀,有时有呕吐,口苦,查体B超显示有胆结石合并胆道感染,诊见肩部酸疼,冷酸感,全身无力,因有心脏病无法手术或碎石治疗,最大结石约0.6×1.0cm大小,用本药物治疗每天4次,每次8克,20天后症状缓解,饮食增加,3个月右肩背酸沉疼消失,复查结石为0.3×0.8cm大小;继服2个月巩固治疗后,复诊B超显示未见结石出现,随诊1年半未见复发,恢复健康。
3、刘某,男,59岁,服用本发明前因急性胰腺炎住院,经医院B超检查出胆囊有2粒不明物体,大小1.8厘米/1.6厘米,经服用本发明后排出黑色胆固醇结晶体,再做B超检查,黑色不明物体消失。
Claims (6)
1. 一种治疗肝胆结石的中药散剂,其特征在于,所述中药散剂由下述重量份数的药材制成:金钱草31-49份,茵陈25-40份,独角莲20-36份,金银花16-30份,姜黄11-26份,香附9-18份,青皮3-10份,大黄8-14份,白豆蔻2-8份,砂仁3-7份,厚朴1-6份。
2. 根据权利要求1所述的中药散剂,其特征在于,所述中药散剂由下述重量份数的药材制成:金钱草36份,茵陈33份,独角莲28份,金银花21份,姜黄19份,香附11份,青皮7份,大黄11份,白豆蔻6份,砂仁5份,厚朴3份。
3. 根据权利要求1所述的中药散剂,其特征在于,所述中药散剂由下述重量份数的药材制成:金钱草40份,茵陈36份,独角莲30份,金银花25份,姜黄15份,香附14份,青皮9份,大黄13份,白豆蔻7份,砂仁6份,厚朴5份。
4. 制备上述任一项权利要求所述的中药散剂的方法,其特征在于,包括下列步骤:
(1)按照重量配比金钱草、茵陈、独角莲、金银花、姜黄、香附、青皮,加入重量为药材总重量6-11倍的水,65-70摄氏度浸泡18-25个小时;
(2)将步骤(1)中的水温梯度升高到沸腾,保持沸腾状态30-45分钟,过滤得药液和药渣;
(3)将药渣重复步骤(1)和步骤(2)2-8次,合并所得的药液,将药液浓缩成60℃下相对密度为1.15~1.25的稠膏;
(4)将大黄、白豆蔻、砂仁、厚朴研磨成500-800目的细粉末;
(5)将步骤(3)的稠膏、步骤(4)的药物细粉末混合,搅拌混着均匀,烘干制成颗粒剂。
5. 根据权利要求4所述的中药散剂的制备方法,其特征在于,步骤(1)浸泡之前将药材研磨600-900目的粉末。
6. 根据权利要求4所述的中药散剂的制备方法,其特征在于,步骤(2)中的水温梯度升高到沸腾的方式是:水温每4-8分钟升高10摄氏度,并且每升高10摄氏度保持15分钟。
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