CN104524158A - 一种治疗慢性阻塞性肺病的药物组合物 - Google Patents
一种治疗慢性阻塞性肺病的药物组合物 Download PDFInfo
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- CN104524158A CN104524158A CN201510062968.1A CN201510062968A CN104524158A CN 104524158 A CN104524158 A CN 104524158A CN 201510062968 A CN201510062968 A CN 201510062968A CN 104524158 A CN104524158 A CN 104524158A
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Abstract
本发明提供了一种治疗慢性阻塞性肺病的药物组合物，其特征在于该药物组合物处方重量份数计为：生黄芪10-60份，茯苓10-35份，党参10-30份，黄芩10-35份，炒白术5-18份，陈皮5-18份，当归5-18份，桔梗5-18份，川贝5-15份，炙甘草5-15份，升麻1-7份，枇杷叶1-7份。该药物组合物制剂由中药组合物与药学上可接受的载体组成，剂型包括水煎剂、丸剂、胶囊剂、颗粒剂、冲剂、片剂和口服液。本发明组合物具有补脾益肺，化痰通络的功效，对于慢性阻塞性肺病患者疗效显著，无毒副作用。
Description
技术领域
本发明属于中药制剂领域，具体涉及一种治疗慢性阻塞性肺病的药物组合物。
背景技术
慢性阻塞性肺疾病简称慢阻肺(COPD)，是一种破坏性的肺部疾病，是以不完全可逆的气流受限为特征的疾病，气流受限通常呈进行性发展并与肺对有害颗粒或气体的异常炎症反应有关。COPD是一种可以预防和治疗的慢性气道炎症性疾病，COPD虽然是气道的疾病,但对全身的系统影响也不容忽视。感染是COPD发生发展的重要因素之一，病毒，细菌和支原体是本病急性加重的重要因素，病毒主要为流感病毒，鼻病毒，腺病毒和呼吸道合胞病毒等；细菌感染以肺炎链球菌，流感嗜血杆菌，卡他莫拉菌及葡萄球菌为多见。当职业性粉尘及化学物质，如烟雾，过敏原，工业废气及室内空气污染等，浓度过大或接触时间过长，均可能产生与吸烟无关的COPD。大气中的有害气体如二氧化硫，二氧化氮，氯气等损伤气道粘膜和其细胞毒作用，使纤毛清除功能下降，粘液分泌增加，为细菌感染增加条件。
目前慢性阻塞性肺病的治疗药物有多种，主要以化药为主，如支气管扩张剂、吸入糖皮质激素、祛痰和镇咳、抗氧化剂。这些药物虽有一定的疗效，但治标不治本，如糖皮质激素，易复发，极易造成医源性损伤，副作用较大。本方具补脾益肺，化痰通络的功效，对于慢性阻塞性肺病患者疗效显著，无毒副作用。
发明内容
本发明旨在提供一种治疗慢性阻塞性肺病的药物组合物。
为实现上述发明目的，本发明一种治疗慢性阻塞性肺病的药物组合物，其具体方案为：
本发明任一项所述的中药组合物的制剂，其特征在于该药物组合物处方重量份数计为：生黄芪10-60份，茯苓10-35份，党参10-30份，黄芩10-35份，炒白术5-18份，陈皮5-18份，当归5-18份，桔梗5-18份，川贝5-15份，炙甘草5-15份，升麻1-7份，枇杷叶1-7份。
本发明任一项所述的中药组合物的制剂，其特征在于该药物组合物重量份数计为：生黄芪20-50份，茯苓15-30份，党参15-28份，黄芩15-25份，炒白术7-12份，陈皮7-12份，当归7-12份，桔梗7-12份，川贝7-12份，炙甘草7-12份，升麻3-5份，枇杷叶3-5份。
本发明任一项所述的中药组合物的制剂，其特征在于该药物组合物重量份数计为：生黄芪40份，茯苓25份，党参25份，黄芩20份，炒白术10份，陈皮10份，当归8份，桔梗8份，川贝8份，炙甘草10份，升麻4份，枇杷叶4份。
本发明任一项所述的中药组合物的制剂，其特征在于，所述制剂为口服制剂。 本发明任一项所述的中药组合物的制剂，其特征在于，所述制剂由中药组合物与药学上可接受的载体组成，剂型包括水煎剂、丸剂、胶囊剂、颗粒剂、冲剂、片剂和口服液。 本发明任一项所述的中药组合物的制剂，其特征在于，所述制剂为颗粒剂。
本发明任一项所述的中药组合物的制剂，其特征在于，所述颗粒剂的制备方法为：
1）取处方量生黄芪，茯苓，党参，黄芩，炒白术，陈皮，当归，桔梗，川贝，炙甘草，升麻，枇杷叶按比例混合加水煎煮，煎煮时间0.5-3h、加水倍数4-15倍、煎煮次数1-4次，最优工艺：煎煮时间2h、加水倍数6倍、煎煮次数2次；将滤液合并，减压浓缩至相对密度1.20～1.40，得水提液稠膏；
2）将稠膏进行减压干燥，干燥温度为50~80℃，之后粉碎过80目筛，即得浸膏粉；
3）在浸膏粉中加入适当比例的辅料，搅拌均匀，制软材，过10目筛，得湿颗粒；
4） 50～80℃干燥，干颗粒冷却后分别过10目筛和65目筛整粒，即得。 本发明任一项所述的中药组合物的制剂，其特征在于，所述颗粒剂的制备辅料为：蔗糖、乳糖、甘露醇、阿斯巴甜、甜菊糖、糊精、可溶性淀粉、羧甲基纤维素钠、聚维酮中的一种或多种组合。 本发明所述所述的中药组合物在制备治疗慢性阻塞性肺病药物中的应用。 本发明处方各组分药理分析：
生黄芪，性味甘、微温，归脾、肺经；补气，兼有升阳，固表止汗，排脓生肌，利水消肿，安胎益血的作用。
茯苓，味甘、淡，性平。归心、肺、脾、肾经。利水渗湿，健脾，宁心。
党参，味甘，性平。有补中益气、止渴、健脾益肺，养血生津。用于脾肺气虚，食少倦怠，咳嗽虚喘，气血不足，面色萎黄，心悸气短，津伤口渴，内热消渴。
黄芩，味苦，性寒；归肺、胆、脾、大肠、小肠经；清热燥湿，泻火解毒，止血，安胎。
炒白术，健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。
陈皮，味苦、辛，性温。归肺、脾经。理气健脾，燥湿化痰。
当归，甘、辛、温；归肝、心、脾经。补血；活血；调经止痛；润燥滑肠。主血虚诸证；月经不调；经闭；痛经；症瘕结聚；崩漏；虚寒腹痛；痿痹；肌肤麻木；肠燥便难；赤痢后重；痈疽疮疡；跌扑损伤。
桔梗，宣肺，利咽，祛痰，排脓；用于咳嗽痰多，胸闷不畅，咽痛，音哑，肺痈吐脓，疮疡脓成不溃。
川贝，性凉，甘平；入肺经、胃经；润肺、止咳、化痰、平喘，清热化痰。
炙甘草，和中缓急，润肺，解毒，调和诸药。常用于脾胃虚弱，倦怠乏力，心动悸，脉结代，可解附子毒。
升麻，辛、甘，微寒；归肺、脾、大肠、胃经；发表透疹，清热解毒，升阳举陷。
枇杷叶，苦，微寒，清肺止咳，降逆止呕。肺热咳嗽，气逆喘急，胃热呕吐，哕逆。
其中，方中生黄芪、茯苓、党参具有补中益气、健脾益肺，养血生津，为君药；黄芩，炒白术，陈皮，炙甘草为本组合物之臣药；当归，桔梗，川贝为佐药；升麻，枇杷叶为使药。且方中以益气之品为主，辅以润肺、健脾、化痰之药。诸药合用，益气固表，润肺健脾化痰，对于慢性阻塞性肺病患者疗效显著，无毒副作用。
本发明的有益效果在于：本发明所述的中药组合物，根据“开宣肺气，化痰润肺”原则，利用本发明药物组合物益气固表，润肺化痰进行辩证施治，再加强肺功能的锻炼、戒烟、调整生活规律，劳逸结合，清淡饮食等建立良好的生活和工作习惯，可以对慢性阻塞性肺病达到标本兼治的功效。
具体实施方式
下面实施例只为进一步说明本发明，不以任何形式限制本发明范围。
实施例1 本发明组合物颗粒剂处方及制备方法：生黄芪40份，茯苓25份，党参25份，黄芩20份，炒白术10份，陈皮10份，当归8份，桔梗8份，川贝8份，炙甘草10份，升麻4份，枇杷叶4份，混合加水煎煮，煎煮时间2h、加水倍数6倍、煎煮次数2次；将两次滤液合并，减压浓缩至相对密度1.20～1.40，得水提液稠膏；将稠膏进行减压干燥，干燥温度为50~80℃，之后粉碎过80目筛，即得浸膏粉。在浸膏粉中加入适当比例的辅料，辅料拟选用蔗糖或乳糖（无糖型颗粒选用甘露醇、阿斯巴甜、甜菊糖）、可溶性淀粉（糊精、羧甲基纤维素钠、聚维酮）搅拌均匀，制软材，过10目筛，得湿颗粒； 50～80℃干燥，干颗粒冷却后分别过10目筛和65目筛整粒，即得。
实施例2本发明组合物颗粒剂处方及制备方法：生黄芪50份，茯苓35份，党参25份，黄芩15份，炒白术5份，陈皮5份，当归8份，桔梗8份，川贝8份，炙甘草10份，升麻4份，枇杷叶4份，混合加水煎煮，煎煮时间2h、加水倍数6倍、煎煮次数2次；将两次滤液合并，减压浓缩至相对密度1.20～1.40，得水提液稠膏；将稠膏进行减压干燥，干燥温度为50~80℃，之后粉碎过80目筛，即得浸膏粉。在浸膏粉中加入适当比例的辅料，辅料拟选用蔗糖或乳糖（无糖型颗粒选用甘露醇、阿斯巴甜、甜菊糖）、可溶性淀粉（糊精、羧甲基纤维素钠、聚维酮）搅拌均匀，制软材，过10目筛，得湿颗粒； 50～80℃干燥，干颗粒冷却后分别过10目筛和65目筛整粒，即得。
实施例3 本发明组合物颗粒剂处方及制备方法：生黄芪40份，茯苓25份，党参25份，黄芩20份，炒白术10份，陈皮10份，当归8份，桔梗8份，川贝8份，炙甘草10份，升麻4份，枇杷叶4份，混合加水煎煮二次，第一次煎煮3h、加水倍数8倍，第二次煎煮2h、加水倍数6倍；将两次滤液合并，减压浓缩至相对密度1.20～1.40，得水提液稠膏；将稠膏进行减压干燥，干燥温度为50~80℃，之后粉碎过80目筛，即得浸膏粉。在浸膏粉中加入适当比例的辅料，辅料拟选用蔗糖或乳糖（无糖型颗粒选用甘露醇、阿斯巴甜、甜菊糖）、可溶性淀粉（糊精、羧甲基纤维素钠、聚维酮）搅拌均匀，制软材，过10目筛，得湿颗粒；50～80℃干燥，干颗粒冷却后分别过10目筛和65目筛整粒，即得。
实施例4本发明组合物水煎剂处方及制备方法：生黄芪40份，茯苓25份，党参25份，黄芩20份，炒白术10份，陈皮10份，当归8份，桔梗8份，川贝8份，炙甘草10份，升麻4份，枇杷叶4份，混合加6倍质量的水，浸泡2小时后，煎煮2h，过滤；药渣再加4倍质量的水，煎煮1h，过滤；合并两次滤液，制成水煎剂。
实施例5 何某，女，76岁，反复咳嗽咳痰10年，气短，胸闷，临床诊断为慢性阻塞性肺病，医生开药为：实施例1所制备的颗粒剂，每日分3次，每次1包，2周一个疗程，连服二疗程。结果，干罗音消失，略有咳嗽咳痰，气促平缓。
以上详细描述了本发明的较佳具体实施例。应当理解，本领域的普通技术人员无需创造性劳动就可以根据本发明的构思作出诸多修改和变化。因此，凡本技术领域中技术人员依本发明的构思在现有技术的基础上通过逻辑分析、推理或者有限的实验可以得到的技术方案，皆应在由权利要求书所确定的保护范围内。
Claims (10)
1.一种治疗慢性阻塞性肺病的药物组合物，其特征在于该药物组合物处方重量份数计为：生黄芪10-60份，茯苓10-35份，党参10-30份，黄芩10-35份，炒白术5-18份，陈皮5-18份，当归5-18份，桔梗5-18份，川贝5-15份，炙甘草5-15份，升麻1-7份，枇杷叶1-7份。
2.根据权利要求1所述一种慢性阻塞性肺病的药物组合物，其特征在于该药物组合物重量份数计为：生黄芪20-50份，茯苓15-30份，党参15-28份，黄芩15-25份，炒白术7-12份，陈皮7-12份，当归7-12份，桔梗7-12份，川贝7-12份，炙甘草7-12份，升麻3-5份，枇杷叶3-5份。
3.根据权利要求1所述一种慢性阻塞性肺病的药物组合物，其特征在于该药物组合物重量份数计为：生黄芪40份，茯苓25份，党参25份，黄芩20份，炒白术10份，陈皮10份，当归8份，桔梗8份，川贝8份，炙甘草10份，升麻4份，枇杷叶4份。
4.根据权利要求1-3任一项所述的中药组合物的制剂，其特征在于，所述制剂为口服制剂。
5.根据权利要求4所述的制剂，其特征在于，所述制剂由中药组合物与药学上可接受的载体组成，剂型包括水煎剂、丸剂、胶囊剂、颗粒剂、冲剂、片剂和口服液。
6.根据权利要求5所述的制剂，其特征在于，所述制剂为颗粒剂。
7.根据权利要求6所述的制剂，其特征在于，所述颗粒剂的制备方法为：
1）取处方量生黄芪，茯苓，党参，黄芩，炒白术，陈皮，当归，桔梗，川贝，炙甘草，升麻，枇杷叶按比例混合加水煎煮，煎煮时间0.5-3h、加水倍数4-15倍、煎煮次数1-4次；将滤液合并，减压浓缩至相对密度1.20～1.40，得水提液稠膏；
2）将稠膏进行减压干燥，干燥温度为50~80℃，之后粉碎过80目筛，即得浸膏粉；
3）在浸膏粉中加入适当比例的辅料，搅拌均匀，制软材，过10目筛，得湿颗粒；
4） 50～80℃干燥，干颗粒冷却后分别过10目筛和65目筛整粒，即得。
8.根据权利要求7所述的制剂，其特征在于，所述颗粒剂的制备辅料为：蔗糖、乳糖、甘露醇、阿斯巴甜、甜菊糖、糊精、可溶性淀粉、羧甲基纤维素钠、聚维酮中的一种或多种组合。
9.根据权利要求7所述的制剂，其特征在于，所述颗粒剂的制备：步骤1）最优工艺为煎煮时间2h、加水倍数6倍、煎煮次数2次。
10.权利要求1-3任一项所述的中药组合物在制备治疗慢性阻塞性肺病药物中的应用。
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