CN104524156A - Traditional Chinese medicine cataplasma for treating autoimmune thyroiditis - Google Patents
Traditional Chinese medicine cataplasma for treating autoimmune thyroiditis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine cataplasma for treating autoimmune thyroiditis, and a preparation method of the traditional Chinese medicine cataplasma. The effective components of the traditional Chinese medicine cataplasma are prepared from the following raw materials in parts by weight: 45-55 parts of thunberg fritillary bulb, 15-25 parts of Chinese yam, 5-10 parts of radix isatidis, 8-15 parts of albizia flower and 5-10 parts of acaudina molpadioides. The invention further discloses a preparation method of the traditional Chinese medicine cataplasma. An experiment result proves that the traditional Chinese medicine cataplasma disclosed by the invention has a good treatment effect on the autoimmune thyroiditis, is good in transdermal absorption effect, has the advantages of rapidly releasing medicines and rapidly playing medicine effects, and has good clinical application value; and metabolism of the medicine in gastrointestinal tracts can be avoided.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine patcher for the treatment of autoimmune thyroiditis and preparation method thereof.
Background technology
Autoimmune thyroiditis (Autoimmunethyroiditis) is a kind of autoimmune disease comparatively common clinically, also known as Hashimoto's disease, chronic lymphocytic thyroiditis, lymphocytic goiter.Primary disease etiology unknown, pathogenesis is complicated, and onset is slow, and the course of disease is longer.Patient's thyroid is the symptoms such as anthorisma.Its Serologic detection shows as the rising of thyroid autoantibody level and the change of thyroid function.The sickness rate of this disease is only second to hyperthyroidism, accounts for about 20% of thyroid disease.This disease is about 0.3 ~ 1.5/1000 at China's sickness rate, wherein in the majority with 30 ~ 50 years old female patient, along with the increase of content of iodine in diet, rhythm of life change, add the impact of environment incretion interferent, this sick sickness rate has remarkable rising trend in recent years, and the quantity of male patient increases particularly evident, the epidemiology reason that prevalence raises it be unclear that.
Current doctor trained in Western medicine mainly takes hormonotherapy, immunotherapy etc. to treat autoimmune thyroiditis, and curative effect is limited to and side effect is comparatively large, often needs to take Liver protection medicine as diammonium glycyrrhizinate etc. simultaneously, can reduce the damage of medicine to liver.
According to the Silent Neuritis enlargement of primary disease thyroid diffusivity and strong but pliable in texture clinical manifestation, primary disease and hyperthyroidism etc. are all classified as Chinese medicine " goiter " by traditional Chinese medical science field usually, but autoimmune thyroiditis and hyperthyroidism do not belong to same disease in western medicine field, its clinical symptoms is cashed also not identical.
The Chinese medicinal formulae for the treatment of struma lymphomatosa disclosed in domestic periodical document comprises: Huang Zheng etc. disclose a kind of Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Poria, Radix Bupleuri, RADIX CURCUMAE, Rhizoma Cyperi (processed), Fructus Akebiae etc. compound preparation (Huang Zheng. struma lymphomatosa 52 example is treated in the ruling by law of righting clear wart. journal of shanghai Chinese medicine .2003; 37 (11): 34); Peng Bo etc. disclose the composition such as a kind of Radix Astragali, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Ramulus Cinnamomi, Radix Curcumae, Sargassum, Thallus Laminariae (Thallus Eckloniae) compound preparation (Peng Bo. Hashimoto's disease observation of curative effect is treated in the righting wart ruling by law that disappears. Shanxi traditional Chinese medical science .2010; 26 (1): 17); Gao Weiwei etc. disclose the composition such as a kind of Herba Ephedrae (processed), Cornu Cervi tablet, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Cortex Cinnamomi, Rhizoma Curculiginis, Herba Epimedii, Sargassum, Spica Prunellae compound preparation (Gao Weiwei, Yao Chang. the routine clinical observation of warming YANG Circulation Resolving Phlegm treatment struma lymphomatosa 60. Yunnan Chinese medicine magazine .2010; 31 (1): 18); Zhou Guirong etc. disclose the compound preparation (Zhou Guirong of the compositions such as a kind of Radix Ginseng, the Radix Astragali, Rhizoma Atractylodis Macrocephalae preparata, Radix Angelicae Sinensis, Rhizoma Cimicifugae, Radix Bupleuri, Spica Prunellae, the Rhizoma Pinelliae, Sargassum; Xu Pingzhi; Cui Peng, etc. taste treatment chronic lymphocytic thyroiditis 60 of invigorating the spleen and replenishing QI Tonga example. practical tcm internal medicine magazine .2007; 21 (2): 66); Fang Bangjiang etc. disclose the compound preparation (Fang Bangjiang of the Chinese medicine compositions such as a kind of Radix Bupleuri, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Pseudobulbus Cremastrae Seu Pleiones; Sun Lihua; the thin autumn in week, the clinical research of the wart soup treatment chronic lymphocytic thyroiditis that disappears etc. softening the hard mass. Journal of Chinese Integrative Medicine .2006; 4 (4): 355); Liu Aiwu etc. disclose the compound preparation (Liu Aiwu of a kind of Flos Lonicerae, Flos Chrysanthemi, Radix Platycodonis, Spica Prunellae, Radix Scrophulariae etc. Chinese medicine composition; Liu Xiaomin; Miao Deguang; the clinical curative effect analysis of 230 routine Hashimoto's disease patients is treated Deng. the wartization that disappears knot soup. labelling immunoassay and clinical; 2009,16 (5): 313); Zhang Chunhua etc. disclose the Chinese medicine such as a kind of Radix Angelicae Sinensis, Radix Paeoniae, Radix Bupleuri, Poria, the Rhizoma Atractylodis Macrocephalae, Herba Menthae, stewing Rhizoma Zingiberis Recens, Radix Glycyrrhizae Preparata composition compound preparation (Zhang Chunhua. a blue Experience in Treating chronic lymphocytic thyroiditis experience picks cyanines. practical tcm internal medicine magazine, 2008,22 (3): 12).
The domestic patent of invention relevant with autoimmune thyroiditis about 284 sections, wherein granted patent 61 sections.The Chinese medicinal formulae for the treatment of struma lymphomatosa disclosed in domestic patent documentation comprises: Chinese patent literature CN103479768A discloses a kind of compound traditional Chinese medicine composite for the treatment of chronic lymphocytic thyroiditis by Radix Astragali 20 ~ 40 parts, Radix Codonopsis 5 ~ 25 parts, Radix Angelicae Sinensis 5 ~ 25 parts, Rhizoma Chuanxiong 3 ~ 20 parts, Spica Prunellae 5 ~ 25 parts, Radix Bupleuri 10 ~ 30 parts, 10 ~ 30 parts, Poria, Herba Epimedii 5 ~ 25 parts, Exocarpium Citri Rubrum 5 ~ 25 parts, Fructus Aurantii 5 ~ 25 parts, Pericarpium Citri Reticulatae 5 ~ 20 parts, Radix Glycyrrhizae Preparata 3 ~ 9 parts is made, Chinese patent literature CN102764366B discloses a kind of Chinese medicine for the treatment of chronic lymphocytic thyroiditis and is made up of bupleurum Chinese 10-20g, Radix Angelicae Sinensis 15-20g, Radix Paeoniae Alba 13-18g, Rhizoma Cyperi 15-20g, Spica Prunellae 10-20g, Bulbus Fritillariae Thunbergii 10-20g, Semen Vaccariae 10-15g, Sargassum 15-20g, Thallus Laminariae (Thallus Eckloniae) 13-16g, Pericarpium Citri Reticulatae 10-20g, Chinese patent literature CN102764366A discloses a kind of Chinese medicine for the treatment of chronic lymphocytic thyroiditis, is made up of bupleurum Chinese 10-20g, Radix Angelicae Sinensis 15-20g, Radix Paeoniae Alba 13-18g, Rhizoma Cyperi 15-20g, Spica Prunellae 10-20g, Bulbus Fritillariae Thunbergii 10-20g, Semen Vaccariae 10-15g, Sargassum 15-20g, Thallus Laminariae (Thallus Eckloniae) 13-16g, Pericarpium Citri Reticulatae 10-20g, Chinese patent literature CN1261145C discloses a kind of medicine for the treatment of goiter, Rhizoma Sparganii 356 ~ 364, Rhizoma Curcumae 356 ~ 364, Radix Et Rhizoma Rhei 356 ~ 364, Rhizoma Cyperi 356 ~ 364, xanthate 356 ~ 364, Herba Taraxaci 356 ~ 364, Radix Notoginseng 356 ~ 364.Rhizoma Sparganii, Rhizoma Curcumae, pseudo-ginseng blood-circulation-invigovating blood stasis dispelling, Radix Et Rhizoma Rhei, Herba Taraxaci dispersing swelling and dissipating binds, Rhizoma Cyperi circulation of qi promoting, xanthate are specialized in goiter, are aided with the Radix Aucklandiae, Flos Caryophylli, Lignum Aquilariae Resinatum causing resuscitation with aromatic drugs, bleed are descending, Radix Astragali consolidating superficial resistance, protection skin is not burst, trichosanthes fruit, Cortex Magnoliae Officinalis profit expectorant sending down the abnormal ascending QI, Herba Ephedrae disperses expelling pathogenic factors from muscles, Stigma Croci nourishing blood and promoting blood circulation; Chinese patent literature CN101332229B discloses a kind of Prunella plant extract and is preparing the application in prevention and therapy thyroid medicine; Chinese patent literature CN102698043B discloses a kind of pharmaceutical composition for the treatment of thyroid disease, is made up of Olibanum, Myrrha, catechu, Os Draconis, Sanguis Draxonis, Borneolum Syntheticum, Fructus Gardeniae, Fructus Forsythiae, Radix Notoginseng, Flos Carthami, Fructus Aurantii, Radix Platycodonis, Radix Scrophulariae, Radix Cyathulae and Cortex Moutan; Chinese patent literature CN103191306B discloses a kind of external application of Chinese medicine medicine for the treatment of thyroid nodule, is made up of Herba seu Radix Calanthes, Radix Capparis Membranaceae, Radix securidacae, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Carapax Bellamyae quadratae, Pumex, Rhizoma soulieae vaginatae; Chinese patent literature CN103191306B discloses a kind of Chinese medicine for the treatment of autoimmune thyroiditis, is made up, has dispersing liver and promoting blood circulation of Chinese crude drug Radix Bupleuri, Bulbus Fritillariae Thunbergii, Poria, Radix Angelicae Sinensis and Rhizoma Curcumae, the features such as resolving phlegm and softening hard masses eliminating stagnation; Chinese patent literature CN102018928B discloses a kind of Chinese medicine composition for the treatment of hypothyroidism, is made up of Radix Bupleuri, Rhizoma Cyperi, the Radix Aucklandiae, the Radix Linderae, Pericarpium Citri tangerinae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Fructus Amomi, Fructus Amomi Rotundus, Radix Rehmanniae Preparata, Rhizoma dioscoreae (parched), Fructus Lycii, Semen Cuscutae, the Cortex Eucommiae, Fructus Corni, Radix Angelicae Sinensis, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Thallus Laminariae (Thallus Eckloniae), Sargassum, Concha Arcae and sea clam 23 taste Chinese medicine; Chinese patent literature CN101884769B discloses a kind of compositions be made up of Radix Bupleuri, Bulbus Fritillariae Thunbergii, Poria, Radix Angelicae Sinensis, Rhizoma Curcumae 5 taste Chinese medicine.
From above-mentioned document, there is the side effect such as obvious hepar damnification in the medicine of current western medical treatment autoimmune thyroiditis usually, often needs additionally to take protection medicine, reduce the harm to patient; The medicine of Chinese medicine autoimmune thyroiditis has significant curative effect, and safety is higher, and its prescription complicated mechanism is various, there is following shortcoming:
1) Chinese medicine compound is many is prepared by 10 ~ 40 taste raw medicinal materials, and medicine variety is many, and effective substance is indefinite, and therefore great majority can only adopt oral administration, and the drug bioavailability of oral administration is lower, causes the waste of herb resource;
2) treat the Chinese medicine compound of autoimmune thyroiditis at present, only a few can be prepared by 5 taste raw medicinal materials, but also there is effective substance unstructured problem, and is only prepared into oral preparation drug administration, and bioavailability is lower;
3) Chinese medicine compound of autoimmune thyroiditis is treated at present, only a few can be prepared into liniment, but for the consideration such as drug releasing rate and drug loading, only can be prepared into simple pasty mixture coating affected part, this drug adhesion power is not strong, patient's administration is inconvenient, and affects attractive in appearance, and patient compliance is poor.
Summary of the invention
For above-mentioned prior art, an object of the present invention is to provide a kind of Chinese medicine patcher for the treatment of autoimmune thyroiditis.For realizing above-mentioned object, the technical solution used in the present invention is:
A kind of Chinese medicine patcher for the treatment of autoimmune thyroiditis, the active component of the Chinese medicine patcher of described treatment autoimmune thyroiditis is made up of the raw medicinal material of following weight part ratio: Bulbus Fritillariae Thunbergii 45 ~ 55 weight portion, Rhizoma Dioscoreae 15 ~ 25 weight portion, Radix Isatidis 5 ~ 10 weight portion, Flos Albiziae 8 ~ 15 weight portion, Acaudina molpadioides 5 ~ 10 weight portion.
As the further optimization of technical solution of the present invention, the active component of the Chinese medicine patcher of described treatment autoimmune thyroiditis is made up of the raw medicinal material of following weight part ratio: Bulbus Fritillariae Thunbergii 50 weight portion, Rhizoma Dioscoreae 22 weight portion, Radix Isatidis 9 weight portion, Flos Albiziae 12 weight portion, Acaudina molpadioides 6 weight portion.
Another aspect of the present invention additionally provides the preparation method of the Chinese medicine patcher of above-mentioned treatment autoimmune thyroiditis, comprises the following steps:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 2 ~ 8g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum;
6) get the Acritamer 940 that weight is raw medicinal material gross weight 0.07 ~ 0.1 times, join in 10 times amount purified water, hold over night, adding pH adjusting agent adjustment pH is 7, as A phase;
7) sodium carboxymethyl cellulose that weight is raw medicinal material gross weight 0.1 ~ 0.14 times is got, join in 7 times amount purified water fully swelling, add kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phase;
8) get that step 5) gained raw medicinal material extractum adds Macrogol 200, glycerol stirs, as C phase;
9) A is added in B phase; as D phase after stirring; C is added in D phase; back lining materials is coated after stirring; coating thickness is 0.5 ~ 0.8mm, adds a cover nonadherent protective layer, is cut into the rectangle that specification is long 1 ~ 4 cm, wide 0.8 ~ 2 cm; subpackage, must treat the Chinese medicine patcher of autoimmune thyroiditis.
Be NaOH as pH adjusting agent in the described step 6) of further optimization of technical solution of the present invention; In described step 7), the consumption of kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide is followed successively by 0.18 ~ 0.22 times, 0.003 ~ 0.006 times, 0.005 ~ 0.008 times, 0.1 ~ 0.12 times, 0.09 ~ 0.12 times of raw medicinal material gross weight; In described step 8), the consumption of Macrogol 200, glycerol is followed successively by 0.07 ~ 0.1 times, 0.1 ~ 0.15 times of raw medicinal material gross weight; In described step 9), rectangle specification is wide 1 cm of long 2 cm.
As the further optimization of technical solution of the present invention, in described step 7), the consumption of kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide is followed successively by 0.2 times, 0.005 times, 0.007 times, 0.105 times, 0.1 times of raw medicinal material gross weight; In described step 8), the consumption of Macrogol 200, glycerol is followed successively by 0.08 times, 0.12 times of raw medicinal material gross weight.
As the further optimization of technical solution of the present invention, in described step 9), back lining materials is non-woven fabrics; In described step 9), nonadherent protective layer is polyethylene film.
Technical solution of the present invention term used " raw medicinal material " is also called Chinese crude drug, and this is known in those skilled in the art.
The weight sum of the Chinese crude drug used in technical solution of the present invention term used " raw medicinal material gross weight " i.e. prescription, this is known in those skilled in the art.
Technical solution of the present invention term used " solid-liquid ratio " refers to the quality of solid-state " material " and the ratio as the volume of " liquid " of extracting solution.When in the extraction preparation of raw medicinal material, extracting solution consumption adopts solid-liquid ratio to describe, the measurement unit of described solid-liquid ratio is g:mL, and if solid-liquid ratio is 1:7, be 1g raw medicinal material and add 7mL extracting solution, this belongs to technology general knowledge to those skilled in the art.
" Bulbus Fritillariae Thunbergii " described in technical solution of the present invention is the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii Fritillaria thunbergii Miq., and this is known in those skilled in the art.
" Rhizoma Dioscoreae " described in technical solution of the present invention is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb., and this is known in those skilled in the art.
" Radix Isatidis " described in technical solution of the present invention is the dry root of cruciferae isatis Isatis indigotica Fort., and this is known in those skilled in the art.
" Flos Albiziae " described in technical solution of the present invention is the dry inflorescence of leguminous plant Herba Albiziae Albizia julibrissin Durazz., and this is known in those skilled in the art.
" Acaudina molpadioides " described in technical solution of the present invention is Echinodermata (Echinodermata) Holothuroidea (Holothuroidea), Molpadida (Molpadida) Kao Can section (Caudinidae), Acaudina (Acaudina) animal.This is known in those skilled in the art.
" coating thickness " described in technical solution of the present invention refers to the medicated layer thickness coating back lining materials, and this is known in those skilled in the art.Selection and relevant this of drug loading ability of coating thickness and excipient substance are known in those skilled in the art.Usual coating thickness regulates by the adjusting device of coating apparatus, and the coating thickness of artificial scraper type coating and cylinder coating is by thickness measuring Instrument measuring, and this is known in those skilled in the art.
The present inventor finds unexpectedly in research process, and the traditional Chinese compound medicine be made up of according to a certain percentage Bulbus Fritillariae Thunbergii, Rhizoma Dioscoreae, Radix Isatidis, Flos Albiziae, Acaudina molpadioides has therapeutic effect beyond expectation to autoimmune thyroiditis.This compound medicine is affixed on the skin of neck thyroid correspondence position after being prepared into Chinese medicine patcher, energy Transdermal absorption arrives thyroid fast and plays desirable drug effect.And this compound medicine medical material used is less, prepares Chinese medicine patcher drug loading large, cataplasma can be cut into less area, realize accurate administration.Cataplasma only can be affixed on neck Ipsilateral thyroid correspondence position by the patient for one-sided thyromegaly, and cataplasma can be affixed on neck bilateral thyroid correspondence position by patient for bilateral thyromegaly respectively.The Chinese medicine patcher for the treatment of autoimmune thyroiditis of the present invention can be cut into less area greatly due to drug loading, and it is convenient to paste, relatively little to patient's aesthetic effects, can improve the compliance of patient, be conducive to clinical practice.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further explained.Should be understood that, following examples only for explaining the present invention, instead of limit the scope of the invention.
embodiment 1the Chinese medicine patcher for the treatment of autoimmune thyroiditis and preparation thereof
Raw medicinal material: Bulbus Fritillariae Thunbergii 500g, Rhizoma Dioscoreae 220g, Radix Isatidis 90g, Flos Albiziae 120g, Acaudina molpadioides 60g.
Pharmaceutic adjuvant: Acritamer 940 79.2g, sodium carboxymethyl cellulose 118.8g, kieselguhr 198g, dihydroxy aluminum glycinate 4.95g, citric acid 6.93g, polyvinylpyrrolidone 103.95, decyl methyl sulfoxide 99g, Macrogol 200 79.2g, glycerol 118.8g.
Preparation method:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 7g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum;
6) getting Acritamer 940 joins in 10 times amount purified water, hold over night, adds NaOH and regulates pH to be 7, as A phase;
7) get sodium carboxymethyl cellulose, join in 7 times amount purified water fully swelling, add kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phase;
8) get that step 5) gained raw medicinal material extractum adds Macrogol 200, glycerol stirs, as C phase;
9) A is added in B phase, as D phase after stirring, C is added in D phase, non-woven fabrics is coated after stirring, coating thickness is 0.7mm, adds a cover polyethylene film, is cut into the rectangle that specification length is wide 1 cm of 2 cm, subpackage, must treat the Chinese medicine patcher of autoimmune thyroiditis.
embodiment 2the Chinese medicine patcher for the treatment of autoimmune thyroiditis and preparation thereof
Raw medicinal material: Bulbus Fritillariae Thunbergii 540g, Rhizoma Dioscoreae 180g, Radix Isatidis 70g, Flos Albiziae 90g, Acaudina molpadioides 90g.
Pharmaceutic adjuvant: Acritamer 940 87.3g, sodium carboxymethyl cellulose 126.1g, kieselguhr 203.7g, dihydroxy aluminum glycinate 3.88g, citric acid 5.82g, polyvinylpyrrolidone 106.7, decyl methyl sulfoxide 106.7, Macrogol 200 87.3g, glycerol 135.8g.
Preparation method:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 5g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum;
6) getting Acritamer 940 joins in 10 times amount purified water, hold over night, adds NaOH and regulates pH to be 7, as A phase;
7) get sodium carboxymethyl cellulose, join in 7 times amount purified water fully swelling, add kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phase;
8) get that step 5) gained raw medicinal material extractum adds Macrogol 200, glycerol stirs, as C phase;
9) A is added in B phase, as D phase after stirring, C is added in D phase, non-woven fabrics is coated after stirring, coating thickness is 0.6mm, adds a cover polyethylene film, is cut into the rectangle that specification length is wide 1 cm of 3 cm, subpackage, must treat the Chinese medicine patcher of autoimmune thyroiditis.
embodiment 3the Chinese medicine patcher for the treatment of autoimmune thyroiditis and preparation thereof
Raw medicinal material: Bulbus Fritillariae Thunbergii 460g, Rhizoma Dioscoreae 200g, Radix Isatidis 60g, Flos Albiziae 140g, Acaudina molpadioides 70g.
Pharmaceutic adjuvant: Acritamer 940 74.4g, sodium carboxymethyl cellulose 102.3g, kieselguhr 176.7g, dihydroxy aluminum glycinate 3.72g, citric acid 6.51g, polyvinylpyrrolidone 102.3, decyl methyl sulfoxide 97.65, Macrogol 200 69.8g, glycerol 102.3g.
Preparation method:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 3g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum;
6) getting Acritamer 940 joins in 10 times amount purified water, hold over night, adds NaOH and regulates pH to be 7, as A phase;
7) get sodium carboxymethyl cellulose, join in 7 times amount purified water fully swelling, add kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phase;
8) get that step 5) gained raw medicinal material extractum adds Macrogol 200, glycerol stirs, as C phase;
9) A is added in B phase, as D phase after stirring, C is added in D phase, non-woven fabrics is coated after stirring, coating thickness is 0.6mm, adds a cover polyethylene film, is cut into the rectangle that specification length is wide 1 cm of 3 cm, subpackage, must treat the Chinese medicine patcher of autoimmune thyroiditis.
embodiment 4the Chinese medicine patcher for the treatment of autoimmune thyroiditis and preparation thereof
Raw medicinal material: Bulbus Fritillariae Thunbergii 500g, Rhizoma Dioscoreae 220g, Radix Isatidis 90g, Flos Albiziae 120g, Acaudina molpadioides 60g.
Pharmaceutic adjuvant: Acritamer 940 79.2g, sodium carboxymethyl cellulose 118.8g, kieselguhr 198g, dihydroxy aluminum glycinate 4.95g, citric acid 6.93g, polyvinylpyrrolidone 103.95, decyl methyl sulfoxide 99g, Macrogol 200 79.2g, glycerol 118.8g.
Preparation method:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 5g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum;
6) getting Acritamer 940 joins in 10 times amount purified water, hold over night, adds NaOH and regulates pH to be 7, as A phase;
7) get sodium carboxymethyl cellulose, join in 7 times amount purified water fully swelling, add kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phase;
8) get that step 5) gained raw medicinal material extractum adds Macrogol 200, glycerol stirs, as C phase;
9) A is added in B phase, as D phase after stirring, C is added in D phase, stretch fabric is coated after stirring, coating thickness is 0.7mm, adds a cover polyethylene film, is cut into the rectangle that specification length is wide 1 cm of 2 cm, subpackage, must treat the Chinese medicine patcher of autoimmune thyroiditis.
embodiment 5the Chinese medicine patcher for the treatment of autoimmune thyroiditis and preparation thereof
Raw medicinal material: Bulbus Fritillariae Thunbergii 540g, Rhizoma Dioscoreae 180g, Radix Isatidis 70g, Flos Albiziae 90g, Acaudina molpadioides 90g.
Pharmaceutic adjuvant: Acritamer 940 87.3g, sodium carboxymethyl cellulose 126.1g, kieselguhr 203.7g, dihydroxy aluminum glycinate 3.88g, citric acid 5.82g, polyvinylpyrrolidone 106.7, decyl methyl sulfoxide 106.7, Macrogol 200 87.3g, glycerol 135.8g.
Preparation method:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 7g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum;
6) getting Acritamer 940 joins in 10 times amount purified water, hold over night, adds NaOH and regulates pH to be 7, as A phase;
7) get sodium carboxymethyl cellulose, join in 7 times amount purified water fully swelling, add kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phase;
8) get that step 5) gained raw medicinal material extractum adds Macrogol 200, glycerol stirs, as C phase;
9) A is added in B phase, as D phase after stirring, C is added in D phase, spun laced fabric is coated after stirring, coating thickness is 0.6mm, adds a cover polyethylene film, is cut into the rectangle that specification length is wide 1 cm of 3 cm, subpackage, must treat the Chinese medicine patcher of autoimmune thyroiditis.
embodiment 6the pharmacodynamic study of the Chinese medicine patcher for the treatment of autoimmune thyroiditis
For verifying drug effect and the advantage of the Chinese medicine patcher for the treatment of autoimmune thyroiditis of the present invention, special standby Chinese medicine compound contrast agents 3 kinds, its preparation method is as follows:
The extractum that the first contrast agents (contrast 1) is prepared for embodiment 1 raw medicinal material extracting solution, prescription and preparation method as follows:
Raw medicinal material: Bulbus Fritillariae Thunbergii 500g, Rhizoma Dioscoreae 220g, Radix Isatidis 90g, Flos Albiziae 120g, Acaudina molpadioides 60g.
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 14g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum.
The extractum that the second contrast agents (contrast 2) is prepared for enforcement 2 raw medicinal material extracting solution, prescription and preparation method as follows:
Raw medicinal material: Bulbus Fritillariae Thunbergii 540g, Rhizoma Dioscoreae 180g, Radix Isatidis 70g, Flos Albiziae 90g, Acaudina molpadioides 90g.
Preparation method:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 14g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum.
The extractum that the third contrast agents (contrast 3) is prepared for enforcement 3 raw medicinal material extracting solution, prescription and preparation method as follows:
Raw medicinal material: Bulbus Fritillariae Thunbergii 460g, Rhizoma Dioscoreae 200g, Radix Isatidis 60g, Flos Albiziae 140g, Acaudina molpadioides 70g.
Preparation method:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 14g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum.
Except above-mentioned self-control contrast agents, separately establish Tripterygium wilfordii Polyglycosidium Tablets (Xieli Pharmaceutical Co., Ltd., Hunan's production) medicament (contrast 4) as a comparison.
Test method and result as follows:
Regular grade Healthy female SD rat, is provided by Heilongjiang University of Chinese Medicine's animal experimental center, body weight 140 ~ 210g.After adaptability raises 2 weeks, get rat 80 at random, be divided into 8 groups at random, 1-7 group is administration model group, and the 8th group is normal group not modeling not administration.
The preparation of complete Freund's adjuvant and incomplete Freund's adjuvant antigen (PTg) Emulsion:
Get the solution that PTg normal saline becomes 0. 1% concentration.Again by itself and Split completely (purchased from GIBCO company) or not exclusively freund adjuvant (purchased from GIBCO company) mix by 1:1 (V/V), make water in oil emulsion, in every milliliter of Emulsion, contain 0. 5 mg PTg.
1-7 group rat respectively back multiple spot subcutaneous injection complete Freund's adjuvant antigen Emulsion 0. 2 mL (containing PTg100 μ g) carries out initial immunity, with incomplete freund adjuvant antigen Emulsion 0. 2 mL booster immunization after 2 weeks, later booster immunization weekly 1 time, terminated immunity to the 6th week, the 8th group of Normal group does not do modeling process.
After modeling success, each group dosage and frequency as follows:
1-3 group rat: remove cervical region Mus hair with shears or electric shaver after anesthesia, be coated with skin of neck with 8%Nas, repeatedly clean up with warm water.1st group of rat sticks the cataplasma of embodiment 1 preparation in cervical region thyroid carcinoma position, cataplasma area is 2x1cm
2.Within every 3 days, paste 1 dose (1 note), altogether note 27 days.2nd group of rat sticks the cataplasma of embodiment 2 preparation in cervical region thyroid carcinoma position, cataplasma area is 2x1cm
2.Within every 3 days, paste 1 dose (1 note), altogether note 27 days.3rd group of rat sticks the cataplasma of enforcement 3 preparation in cervical region thyroid carcinoma position, cataplasma area is 2x1cm
2.Within every 3 days, paste 1 dose (1 note), altogether note 27 days.
4-6 group rat respectively gavage gives contrast 1, contrast 2, contrast 3 three kinds of contrast agents, every day gastric infusion once, each gavage gives 2mL raw medicinal material extractum, altogether administration 27 days.The water that 7th group of rat oral gavage gives the contrast agents (Tripterygium wilfordii Polyglycosidium Tablets) of contrast 4 mixes liquid, and dosage is calculated as 20mg/kg according to tripterygium glycosides, every day gastric infusion once, administration 27 days altogether.8th group of rat not modeling not administration.
Respectively at after each group of rat administration the 3rd, 6,12,27 day, retroorbital venous clump blood sampling 3mL, separation of serum (-80 DEG C
Frozen for subsequent use).Get frozen rat blood serum, thaw under room temperature, carry out TGAb, TPOA b by TGAb, TPOAb radioimmunoassay kit (purchased from Beijing Fu Rui bio-engineering corporation) detecting step and measure.Result is respectively in table 1, table 2.
Table 1 is group rat blood serum TGAb tables of data respectively
1: p < 0.05 compared with the 7th group;
2: p < 0.05 compared with the 8th group.
From table 1,1, after 2,3 groups of rat blood serum TGAb self administration of medication the 6th day remarkable in 4-7 group, wherein the 1st group of rat upon administration the 27th day serum TG Ab and the 8th group without significant difference, point out the Chinese medicine patcher for the treatment of autoimmune thyroiditis of the present invention to have good therapeutic effect to autoimmune thyroiditis, and drug effect play speed significantly faster than oral Preparation.
Table 2 is group rat blood serum TPOAb tables of data respectively
From table 2,1, after 2,3 groups of rat blood serum TPOAb self administration of medication the 3rd day remarkable in 4-7 group, wherein the 1st group of rat upon administration the 27th day serum TG Ab and the 8th group without significant difference, point out the Chinese medicine patcher for the treatment of autoimmune thyroiditis of the present invention to have good therapeutic effect to autoimmune thyroiditis, and drug effect play speed significantly faster than oral Preparation.
To autoimmune thyroiditis, there is good therapeutic effect by the Chinese medicine patcher of table 1, the visible treatment autoimmune thyroiditis of the present invention of table 2, compared with having proved the Tripterygium wilfordii Polyglycosidium Tablets of determined curative effect at present, there is significant advantage, there is the advantage that rapid delivery of pharmaceuticals plays rapidly drug effect, Transdermal absorption is effective, has good clinical value.
Claims (6)
1. treat the Chinese medicine patcher of autoimmune thyroiditis for one kind, it is characterized in that, the active component of the Chinese medicine patcher of described treatment autoimmune thyroiditis is made up of the raw medicinal material of following weight part ratio: Bulbus Fritillariae Thunbergii 45 ~ 55 weight portion, Rhizoma Dioscoreae 15 ~ 25 weight portion, Radix Isatidis 5 ~ 10 weight portion, Flos Albiziae 8 ~ 15 weight portion, Acaudina molpadioides 5 ~ 10 weight portion.
2. the Chinese medicine patcher for the treatment of autoimmune thyroiditis according to claim 1, it is characterized in that, the active component of the Chinese medicine patcher of described treatment autoimmune thyroiditis is made up of the raw medicinal material of following weight part ratio: Bulbus Fritillariae Thunbergii 50 weight portion, Rhizoma Dioscoreae 22 weight portion, Radix Isatidis 9 weight portion, Flos Albiziae 12 weight portion, Acaudina molpadioides 6 weight portion.
3. the preparation method of the Chinese medicine patcher of the treatment autoimmune thyroiditis described in claim 1 or 2, is characterized in that, comprise the following steps:
1) get Rhizoma Dioscoreae peeling, be cut into the thin slice that thickness is 2mm, pulverize after drying at 50 DEG C, cross 100 mesh sieves, obtain Rhizoma Dioscoreae powder;
2) be that the ratio of 1:6 adds to step 1) gained medicinal powder the ethanol that concentration is 70%, water bath with thermostatic control reflux, extract, 4h at 60 DEG C according to solid-liquid ratio, filtered while hot, obtains Rhizoma Dioscoreae extracting solution;
3) get Acaudina molpadioides to gill, clean dewatering, dry at 30 DEG C, the ratio being 1:3 according to solid-liquid ratio adds the ethanol that concentration is 70%, extracting at constant temperature 10h at 50 DEG C, filters to obtain Acaudina molpadioides extracting solution;
4) get Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae pulverizing, cross 80 mesh sieves, the ratio being 1:7 according to solid-liquid ratio adds the ethanol that concentration is 75%, water bath with thermostatic control reflux, extract, 3 times at 90 DEG C, each 3h, mixes extracting solution, obtains Bulbus Fritillariae Thunbergii, Radix Isatidis, Flos Albiziae mixed extract;
5) by step 2), 3), 4) gained extracting solution mixing, concentrating under reduced pressure, makes extract concentration be calculated as 2 ~ 8g/mL according to medical material gross weight/extracting liquid volume, obtains raw medicinal material extractum;
6) get the Acritamer 940 that weight is raw medicinal material gross weight 0.07 ~ 0.1 times, join in 10 times amount purified water, hold over night, adding pH adjusting agent adjustment pH is 7, as A phase;
7) sodium carboxymethyl cellulose that weight is raw medicinal material gross weight 0.1 ~ 0.14 times is got, join in 7 times amount purified water fully swelling, add kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phase;
8) get that step 5) gained raw medicinal material extractum adds Macrogol 200, glycerol stirs, as C phase;
9) A is added in B phase; as D phase after stirring; C is added in D phase; back lining materials is coated after stirring; coating thickness is 0.5 ~ 0.8mm, adds a cover nonadherent protective layer, is cut into the rectangle that specification is long 1 ~ 4 cm, wide 0.8 ~ 2 cm; subpackage, must treat the Chinese medicine patcher of autoimmune thyroiditis.
4. the preparation method of the Chinese medicine patcher for the treatment of autoimmune thyroiditis according to claim 3, is characterized in that, in described step 6), pH adjusting agent is NaOH; In described step 7), the consumption of kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide is followed successively by 0.18 ~ 0.22 times, 0.003 ~ 0.006 times, 0.005 ~ 0.008 times, 0.1 ~ 0.12 times, 0.09 ~ 0.12 times of raw medicinal material gross weight; In described step 8), the consumption of Macrogol 200, glycerol is followed successively by 0.07 ~ 0.1 times, 0.1 ~ 0.15 times of raw medicinal material gross weight; In described step 9), rectangle specification is wide 1 cm of long 2 cm.
5. the preparation method of the Chinese medicine patcher for the treatment of autoimmune thyroiditis according to claim 4, it is characterized in that, in described step 7), the consumption of kieselguhr, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide is followed successively by 0.2 times, 0.005 times, 0.007 times, 0.105 times, 0.1 times of raw medicinal material gross weight; In described step 8), the consumption of Macrogol 200, glycerol is followed successively by 0.08 times, 0.12 times of raw medicinal material gross weight.
6. the preparation method of the Chinese medicine patcher of the treatment autoimmune thyroiditis according to any one of claim 3 to 5, is characterized in that, in described step 9), back lining materials is non-woven fabrics; In described step 9), nonadherent protective layer is polyethylene film.
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