CN101884769A - Traditional Chinese medicine for treating autoimmune thyroiditis and production method - Google Patents
Traditional Chinese medicine for treating autoimmune thyroiditis and production method Download PDFInfo
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- CN101884769A CN101884769A CN 201010220817 CN201010220817A CN101884769A CN 101884769 A CN101884769 A CN 101884769A CN 201010220817 CN201010220817 CN 201010220817 CN 201010220817 A CN201010220817 A CN 201010220817A CN 101884769 A CN101884769 A CN 101884769A
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Abstract
The invention relates to a traditional Chinese medicine for treating autoimmune thyroiditis, which is characterized in that the traditional Chinese medicine is prepared from the following Chinese medicinal materials by mass: 250 to 300 grams of Chinese thorowax root, 150 to 170 grams of thunberg fritillary bulb, 250 to 300 grams of Indian buead, 150 to 170 grams of Chinese angelica and 150 to 170 grams of zedoary. The traditional Chinese medicine is a Chinese medicinal compound preparation for treating the autoimmune thyroiditis, and has the characteristics of soothing the liver and invigorating blood circulation, reducing phlegm and softening hard lumps and dispelling nodes.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly relate to a kind of Chinese medicine for the treatment of autoimmune thyroiditis.
Background technology
Autoimmune thyroiditis (autoimmune thyroiditis, AITD) be a kind of common organ specificity autoimmune disease, its main feature is the chronic inflammatory disease pathological changes of destroying based on local a large amount of lymphocytic infiltrations of thyroid and follicular epithelial cells, and the serology detected representation is the rising of thyroid autoantibody level and the change of thyroid function.This sick sickness rate is only second to hyperthyroidism, accounts for about 20% of thyroid disease.Along with the change of the increase of content of iodine in the diet, rhythm of life, add the influence of environment incretion interferent, the sickness rate of primary disease presents the trend that increases year by year.
Still fail to illustrate the pathogenesis of primary disease at present both at home and abroad, and lack the active drug of treatment primary disease, just utilize hormone or immunosuppressant to carry out symptomatic treatment usually, though can produce certain effect, but its side effect is bigger, in case and drug withdrawal the shortcoming of easy recurrence is arranged.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of Chinese medicine to the autoimmune thyroiditis treatment, and trade name is a bavin shellfish sheet." bavin shellfish sheet " ties up on the basis of year clinical treatment autoimmune thyroiditis determined curative effect surplus in the of 20, in conjunction with the modern Chinese medicine compound preparation of modern pharmaceutical technology development.This medicine is made up of 5 flavor Chinese medicines such as Radix Bupleuri, Bulbus Fritillariae Thunbergii, Poria, Radix Angelicae Sinensis, Rhizoma Curcumae, has dispersing liver and promoting blood circulation, and the effect of resolving phlegm and softening hard masses is used for the treatment of autoimmune thyroiditis.Observe and pharmacodynamic study shows that this compound recipe can effectively reduce the serum antibody level of AITD through nearly thousand routine AITD patients are near, alleviate or repair impaired thyroid cell structure.
New drug research determines that the technical scheme that adopts is:
A kind of Chinese medicine for the treatment of autoimmune thyroiditis, be formulated by Radix Bupleuri, Bulbus Fritillariae Thunbergii, Poria, Radix Angelicae Sinensis, Rhizoma Curcumae 5 flavor Chinese medicines, its raw medicinal herbs compatibility is: Radix Bupleuri 250-300g, Bulbus Fritillariae Thunbergii 150-170g, Poria 250-300g, Radix Angelicae Sinensis 150-170g, Rhizoma Curcumae 150-170g.
Producing a kind of production method for the treatment of autoimmune thyroiditis Chinese medicine of the present invention is:
Get 10-20 purpose Bulbus Fritillariae Thunbergii coarse powder 150-170g and place the shaking table agitator, shaking table agitator rotating speed is 150-200r/min, extracts 40-50h, filters, and filtrate is concentrated into that relative density is 1.05-1.10 under 50-60 ℃ of temperature, spray drying, fine powder is standby; Get 10-20 purpose Radix Bupleuri coarse powder 250-300g, 10-20 purpose Radix Angelicae Sinensis coarse powder 150-170g, 10-20 purpose Rhizoma Curcumae coarse powder 150-170g adopts CO
2Supercritical fluid extraction; Extraction conditions is: the extraction kettle temperature is 40-50 ℃, and pressure is 20-30mpa, and the first extraction-container temperature is 50-60 ℃, pressure is 7-8mpa, and the second extraction-container temperature is 60-70 ℃, and pressure is 7-8mpa, the detached dowel temperature is 40-50 ℃, and pressure is 7-8mpa, gets volatile oil; Got volatile oil 1 minute, beta-schardinger dextrin-4-6 part adopts saturated water solution method to carry out enclose, gets clathrate, and is standby; Get 10-20 purpose Poria coarse powder 250-300g and above-mentioned medicinal residues and merge, add 8-10 times of water gaging and extract secondary, each 1-2 hour, filter, filtrate is concentrated into that relative density is 1.02-1.15 under 50 ℃ of temperature, and spray drying gets fine powder; Above-mentioned two fine powders add beta-schardinger dextrin-bag and thing, add suitable adjuvant, mix, and granulate, and make plain sheet, and film coating gets finished product.
Function cures mainly: dispersing liver and promoting blood circulation, resolving phlegm and softening hard masses.Be used for autoimmune thyroiditis.
Dosage form: Film coated tablets.Specification: every 0.5 gram.
Usage: oral, 2-3 time on the one.Consumption: at every turn take 4～5.
The side separates: autoimmune thyroiditis belongs to the traditional Chinese medical science " goiter " category, and main performance is that the throat lump is rounded, and smooth surface moves up and down with swallowing; When lump increases, dyspnea can be arranged, dysphagia, hoarseness, can be with cardiopalmus, become thin, symptoms such as agitation, insomnia and dreamful sleep, exophthalmos.Bavin shellfish sheet is according to its stagnation of QI due to depression of the liver, stagnation of QI body fluid cloth not; Insufficiency of the spleen can not transmitting and distributing the fluids, Tianjin is poly-coagulates for expectorant causes expectorant, qi depression to blood stasis is stopped up knot mutually and is hindered pathogenesis in the throat, is monarch drug with Radix Bupleuri, dispersing the stagnated live-QI to relieve the stagnation of QI, harmonizing the functional activities of vital QI, and Radix Bupleuri is the Liver Channel guiding drug; Bulbus Fritillariae Thunbergii is a ministerial drug, the resolving phlegm and softening hard masses eliminating stagnation; Poria spleen invigorating eliminating dampness by diuresis is to reduce phlegm, and the Radix Angelicae Sinensis nourishing blood and promoting blood circulation is with blood stasis dispelling, and Rhizoma Curcumae circulation of qi promoting removing blood stasis helps the effect of phlegm reduction of blood circulation promoting eliminating stagnation altogether with eliminating stagnation.
Pharmacodynamic study:
1. bavin shellfish sheet is to the therapeutical effect of autoimmune thyroiditis mice:
Table 1 bavin shellfish sheet is to the effect of autoimmune thyroiditis mice TGAb, TPOAb, FT4, FT3, TSH
Annotate: ▲ model group and normal group be P=0.001 relatively, and model group and Chinese drug-treated group be P=0.001 relatively ◆, ● model group and Glucosidorum Tripterygll Totorum group be P=0.005 relatively
2. bavin shellfish sheet is to the therapeutical effect of autoimmune thyroiditis rat:
Table 1 bavin shellfish sheet is to the effect of autoimmune thyroiditis rat blood serum antibody
Compare with model group
#P＜0.01
★ P＜0.05 is compared with the Radix Tripterygii Wilfordii group in P＜0.05
Table 2: bavin shellfish sheet is to the effect of autoimmune thyroiditis rat blood serum IL-1, IL-4
Compare with model group
#P＜0.01
★ P＜0.05 is compared with the Radix Tripterygii Wilfordii group in P＜0.05
Table 3: bavin shellfish sheet is to the effect of autoimmune thyroiditis rat blood serum IL-6, TNF-α
Compare with model group
#P＜0.01
Compare with the Radix Tripterygii Wilfordii group P＜0.05 ◆ P＜0.01 ▲ P＞0.05
Clinical research data: accept outpatient service altogether for medical treatment and autoimmune thyroiditis patient 998 examples of being in hospital, matched group 400 examples wherein, bavin shellfish sheet group 598 examples, chronic lymphocytic thyroiditis's 500 examples, sick 498 examples of Graves, men and women's ratio is 1: 15.Matched group gives antithyroid drug or thyroxin replacement therapy, and bavin shellfish sheet group is oral bavin shellfish sheet on the treatment of control group basis.3 months is 1 course of treatment, treats 2 courses of treatment altogether.The result shows: bavin shellfish sheet group serum TG Ab, TPOAb level and thyroid volume level are starkly lower than matched group, and effective percentage is respectively 91.8%, 89.9% and 93.5% and all is significantly higher than matched group.
The present invention is the compound Chinese medicinal preparation that is used for the treatment of autoimmune thyroiditis, has dispersing liver and promoting blood circulation, characteristics such as resolving phlegm and softening hard masses eliminating stagnation.
The specific embodiment
Embodiment one
A kind of Chinese medicine for the treatment of autoimmune thyroiditis is to be prepared into by Radix Bupleuri 250g, Bulbus Fritillariae Thunbergii 150g, Poria 250g, Radix Angelicae Sinensis 150g, Rhizoma Curcumae 150g.
Embodiment two
A kind of Chinese medicine for the treatment of autoimmune thyroiditis is to be prepared into by Radix Bupleuri 265g, Bulbus Fritillariae Thunbergii 155g, Poria 265g, Radix Angelicae Sinensis 155g, Rhizoma Curcumae 155g.
Embodiment three
A kind of Chinese medicine for the treatment of autoimmune thyroiditis is to be prepared into by Radix Bupleuri 275g, Bulbus Fritillariae Thunbergii 160g, Poria 275g, Radix Angelicae Sinensis 160g, Rhizoma Curcumae 160g.
Embodiment four
A kind of Chinese medicine for the treatment of autoimmune thyroiditis is to be prepared into by Radix Bupleuri 300g, Bulbus Fritillariae Thunbergii 170g, Poria 300g, Radix Angelicae Sinensis 170g, Rhizoma Curcumae 170g.
Embodiment five
A kind of preparation method of Chinese medicine for the treatment of autoimmune thyroiditis is: get Bulbus Fritillariae Thunbergii 150g, adopt the shaking table succusion to extract, extracting solution concentrates, spray drying, and it is standby to get fine powder.Get Radix Bupleuri 250g, Radix Angelicae Sinensis 150g, Rhizoma Curcumae 150g adopts CO
2Supercritical extraction, volatile oil, the beta-schardinger dextrin-bag and, standby.Get Poria 250g and above-mentioned medicinal residues and merge, add 8 times of water gagings and extract secondary, each 2 hours, filter, it is 1.15 (50 ℃) that filtrate is concentrated into relative density, spray drying gets fine powder.Above-mentioned fine powder adds beta-schardinger dextrin-bag and thing, adds suitable adjuvant, mixes, and granulates, and makes plain sheet, and film coating gets finished product.
Claims (6)
1. Chinese medicine for the treatment of autoimmune thyroiditis, it is characterized in that being prepared into by Chinese crude drug Radix Bupleuri, Bulbus Fritillariae Thunbergii, Poria and Radix Angelicae Sinensis, its raw medicinal herbs compatibility is: Radix Bupleuri 250---300g, Bulbus Fritillariae Thunbergii 150---170g, Poria 250---300g, Radix Angelicae Sinensis 150---170g, Rhizoma Curcumae 150---170g.
2. a kind of Chinese medicine for the treatment of autoimmune thyroiditis according to claim 1 is characterized in that being prepared into by Radix Bupleuri 250g, Bulbus Fritillariae Thunbergii 150g, Poria 250g, Radix Angelicae Sinensis 150g, Rhizoma Curcumae 150g.
3. a kind of Chinese medicine for the treatment of autoimmune thyroiditis according to claim 1 is characterized in that being prepared into by Radix Bupleuri 265g, Bulbus Fritillariae Thunbergii 155g, Poria 265g, Radix Angelicae Sinensis 155g, Rhizoma Curcumae 155g.
4. a kind of Chinese medicine for the treatment of autoimmune thyroiditis according to claim 1 is characterized in that being prepared into by Radix Bupleuri 275g, Bulbus Fritillariae Thunbergii 160g, Poria 275g, Radix Angelicae Sinensis 160g, Rhizoma Curcumae 160g.
5. a kind of Chinese medicine for the treatment of autoimmune thyroiditis according to claim 1 is characterized in that being prepared into by Radix Bupleuri 300g, Bulbus Fritillariae Thunbergii 170g, Poria 300g, Radix Angelicae Sinensis 170g, Rhizoma Curcumae 170g.
6. a kind of production method for the treatment of the Chinese medicine of autoimmune thyroiditis according to claim 1, it is characterized in that getting 10-20 purpose Bulbus Fritillariae Thunbergii coarse powder 150-170g and place the shaking table agitator, shaking table agitator rotating speed is 150-200r/min, extract 40-50h, filter, filtrate is concentrated into that relative density is 1.05-1.10 under 50-60 ℃ of temperature, spray drying, fine powder is standby; Get 10-20 purpose Radix Bupleuri coarse powder 250-300g, 10-20 purpose Radix Angelicae Sinensis coarse powder 150-170g, 10-20 purpose Rhizoma Curcumae coarse powder 150-170g employing CO2 supercritical fluid extraction; Extraction conditions is: the extraction kettle temperature is 40-50 ℃, and pressure is 20-30mpa, and the first extraction-container temperature is 50-60 ℃, pressure is 7-8mpa, and the second extraction-container temperature is 60-70 ℃, and pressure is 7-8mpa, the detached dowel temperature is 40-50 ℃, and pressure is 7-8mpa, gets volatile oil; Got volatile oil 1 minute, beta-schardinger dextrin-4-6 part adopts saturated water solution method to carry out enclose, gets clathrate, and is standby; Get 10-20 purpose Poria coarse powder 250-300g and above-mentioned medicinal residues and merge, add 8-10 times of water gaging and extract secondary, each 1-2 hour, filter, filtrate is concentrated into that relative density is 1.15 under 50 ℃ of temperature, and spray drying gets fine powder; Above-mentioned two fine powders add beta-schardinger dextrin-bag and thing, add suitable adjuvant, mix, and granulate, and make plain sheet, and film coating gets finished product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948867A (en) * | 2014-04-30 | 2014-07-30 | 郭如英 | Traditional Chinese medicinal preparation for treating hashimoto thyropathy, resolving depression and breaking stagnation and preparation method thereof |
| CN104524156A (en) * | 2015-01-26 | 2015-04-22 | 黑龙江中医药大学 | Traditional Chinese medicine cataplasma for treating autoimmune thyroiditis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152536A (en) * | 2007-09-15 | 2008-04-02 | 尹克华 | Traditional Chinese medicine for treating Hashimoto's thyroiditis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152536A (en) * | 2007-09-15 | 2008-04-02 | 尹克华 | Traditional Chinese medicine for treating Hashimoto's thyroiditis |
Non-Patent Citations (1)
| Title |
|---|
| 《江苏中医药》 20061231 高国宇等 桥本氏甲状腺炎中医治疗及实验研究概况 57-59 1-6 第27卷, 第1期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948867A (en) * | 2014-04-30 | 2014-07-30 | 郭如英 | Traditional Chinese medicinal preparation for treating hashimoto thyropathy, resolving depression and breaking stagnation and preparation method thereof |
| CN104524156A (en) * | 2015-01-26 | 2015-04-22 | 黑龙江中医药大学 | Traditional Chinese medicine cataplasma for treating autoimmune thyroiditis |
| CN104524156B (en) * | 2015-01-26 | 2017-08-15 | 黑龙江中医药大学 | A kind of Chinese medicine patcher for treating autoimmune thyroiditis |
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