CN104524156B - A kind of Chinese medicine patcher for treating autoimmune thyroiditis - Google Patents
A kind of Chinese medicine patcher for treating autoimmune thyroiditis Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine patcher for treating autoimmune thyroiditis.The active ingredient of the Chinese medicine patcher is prepared from by the parts by weight of fritillaria thunbergii 45~55, the parts by weight of Chinese yam 15~25, the parts by weight of Radix Isatidis 5~10, the parts by weight of Flos Albiziae 8~15, the parts by weight of Haiti melon 5~10.Invention also discloses the preparation method of the Chinese medicine patcher.Test result indicates that the Chinese medicine patcher of the present invention has good therapeutic effect to autoimmune thyroiditis, Transdermal absorption effect is good, medicine can be avoided in the metabolism of intestines and stomach, have the advantages that rapid delivery of pharmaceuticals plays rapidly drug effect, with good clinical value.
Description
Technical field
The invention belongs to tcm field, and in particular to a kind of Chinese medicine patcher for treating autoimmune thyroiditis.
Background technology
Autoimmune thyroiditis（Autoimmunethyroiditis）It is a kind of clinically relatively conventional itself exempt from
Epidemic disease disease, also known as Hashimoto's disease, chronic lymphocytic thyroiditis, lymphocytic goitre.This sick etiology unknown, the interpretation of the cause, onset and process of an illness
Complexity, onset is slow, and the course of disease is longer.In symptoms such as anthorismas more than patient's thyroid gland.Its Serologic detection shows as first shape
The rise of gland autoantibody and the change of thyroid function.The sick incidence of disease is only second to hyperthyroidism, accounts for thyroid disease
20% or so.The disease is about 0.3~1.5/1000 in China's incidence of disease, wherein it is in the majority with 30~50 years old female patient, with
The increase of content of iodine, the change of rhythm of life, the influence plus environment incretion interferent in diet, the in recent years sick incidence of disease
There is notable rise trend, and the quantity increase of male patient is particularly evident, the elevated epidemiology reason of illness rate is unclear.
Current doctor trained in Western medicine mainly takes hormonotherapy, immunotherapy etc. to treat autoimmune thyroiditis, curative effect limitation and
Side effect is larger, generally requires that while take Liver protection medicine such as diammonium glycyrrhizinate etc., damage of the medicine to liver can be reduced.
According to this sick thyroid gland diffusivity Silent Neuritis enlargement and strong but pliable in texture clinical manifestation, traditional Chinese medical science field is generally by this disease
Be classified as traditional Chinese medicine " goiter " with hyperthyroidism etc., but autoimmune thyroiditis with hyperthyroidism in western medicine field
And same disease is not belonging to, its clinical symptoms is cashed and also differed.
The Chinese medicinal formulae for the treatment of Hashimoto's thyroiditis disclosed in domestic periodical document includes：Huang Zheng etc. discloses one kind
The compound preparation of Radix Codonopsis, the bighead atractylodes rhizome, the Radix Astragali, Poria cocos, radix bupleuri, RADIX CURCUMAE, rhizoma cyperi processed, fiveleaf akebia fruit etc.（The yellow clear goitre method treatment of polished rightings
52 Shanghai Chinese magazines .2003 of Hashimoto's thyroiditis;37(11):34）；Peng Bo etc. disclose a kind of Radix Astragali, the root of herbaceous peony,
The compositions such as the red sage root, Poria cocos, the bighead atractylodes rhizome, sealwort, cassia twig, root tuber of aromatic turmeric, marine alga, kelp compound preparation (Peng Bo rightings disappear goitre ruling by law treat bridge
Ben's disease observation of curative effect Shanxi traditional Chinese medical science .2010;26(1):17);Gao Weiwei etc. discloses a kind of ephedra, sliced CORNUS CERVI, cultivated land
Compound preparation (Gao Weiwei, Yao Chang temperature the sun resolving sputum ruling by law of the compositions such as Huang, rhizoma zingiberis, Chinese cassia tree, thizoma curculiginis, HERBA EPIMEDII, marine alga, selfheal
Treat 60 clinical observation Yunnan traditional Chinese medicine magazine .2010 of Hashimoto's thyroiditis;31(1):18);Zhou Guirong etc. is disclosed
A kind of compound preparation of the compositions such as ginseng, the Radix Astragali, Rhizoma Atractylodis Macrocephalae preparata, Radix Angelicae Sinensis, rattletop, radix bupleuri, selfheal, the tuber of pinellia, marine alga（Zhou Guirong,
Xu Pingzhi, Cui Peng, wait the tonifying middle-Jiao and Qis Tonga practical tcm internal medicine magazine .2007 of 60 of taste treatment Hashimoto thyroiditis;21
(2)：66）;Fang Bangjiang etc. discloses a kind of compound preparation of the Chinese medicines such as radix bupleuri, root tuber of aromatic turmeric, rhizoma cyperi, rascal, edible tulip composition（Square nation
River, Sun Lihua, Zhou Xiqiu, wait softening hard masses disappear goitre soup treat chronic lymphocytic thyroiditis the clinical research combination of Chinese tradiational and Western medicine
Journal .2006;4(4):355）；Liu Aiwu etc. discloses a kind of honeysuckle, chrysanthemum, balloonflower root, selfheal, radix scrophulariae etc. Chinese medicine group
Into compound preparation（Liu Aiwu, Liu Xiaomin, Miao Deguang, wait the goitre knot soup that disappears to treat the clinical treatment of 230 Hashimoto's disease patients
Effect analysis labelling immunoassays and clinical, 2009,16 (5):313）;Zhang Chunhua etc. discloses a kind of Radix Angelicae Sinensis, Chinese herbaceous peony, radix bupleuri, Fu
Siberian cocklebur, the bighead atractylodes rhizome, peppermint, the compound preparation for simmering the Chinese medicines such as ginger, honey-fried licorice root composition（The blue Experience in Treating chronic lymphatics of Zhang Chunhua are thin
Born of the same parents' property thyroiditis experience picks the practical tcm internal medicine magazines of cyanines, 2008,22 (3):12）.
The domestic patent of invention about 284 relevant with autoimmune thyroiditis, wherein granted patent 61.It is domestic special
The Chinese medicinal formulae for the treatment of Hashimoto's thyroiditis disclosed in sharp document includes：Chinese patent literature CN103479768A is disclosed
A kind of compound traditional Chinese medicine composite for treating chronic lymphocytic thyroiditis by give birth to 20~40 parts of the Radix Astragali, 5~25 parts of Radix Codonopsis, when
Return 5~25 parts, 3~20 parts of Ligusticum wallichii, 5~25 parts of selfheal, 10~30 parts of radix bupleuri, 10~30 parts of Poria cocos, 5~25 parts of HERBA EPIMEDII,
5~25 parts of Exocarpium Citri Rubrum, 5~25 parts of Fructus Aurantii, 5~20 parts of dried orange peel, 3~9 parts of honey-fried licorice root are made；Chinese patent literature CN102764366B
A kind of Chinese medicine for treating chronic lymphocytic thyroiditis is disclosed by bupleurum Chinese 10-20g, Radix Angelicae Sinensis 15-20g, root of herbaceous peony 13-
18g, rhizoma cyperi 15-20g, selfheal 10-20g, bulb of thunberg fritillary 10-20g, seed of cowherb 10-15g, marine alga 15-20g, kelp 13-16g,
Dried orange peel 10-20g is made；Chinese patent literature CN102764366A discloses a kind of chronic lymphocytic thyroiditis for the treatment of
Chinese medicine, by bupleurum Chinese 10-20g, Radix Angelicae Sinensis 15-20g, root of herbaceous peony 13-18g, rhizoma cyperi 15-20g, selfheal 10-20g, bulb of thunberg fritillary 10-
20g, seed of cowherb 10-15g, marine alga 15-20g, kelp 13-16g, dried orange peel 10-20g are made；Chinese patent literature
CN1261145C discloses a kind of medicine for treating goiter, Rhizoma Sparganii 356~364, curcuma zedoary 356~364, rheum officinale 356~364, perfume
Attached 356~364, xanthate 356~364, dandelion 356~364, pseudo-ginseng 356~364.It is Rhizoma Sparganii, curcuma zedoary, pseudo-ginseng blood-circulation-invigovating stagnation resolvation, big
Huang, dandelion dispersing swelling and dissipating binds, rhizoma cyperi promoting the circulation of qi, xanthate specialize in goiter and tumor, be aided with the banksia rose, cloves, agalloch eaglewood resuscitation with aromatics, bleed it is descending,
The solid table of the Radix Astragali, protects skin not burst, the sharp phlegm sending down abnormally ascending of trichosanthes fruit, the bark of official magnolia, Chinese ephedra diverging expelling pathogenic factors from muscles and skin, safflower blood circulation promoting nourishes blood；It is Chinese special
Sharp document CN101332229B discloses a kind of Prunella plant extract and its prevents and treats thyroid gland medicine preparing
In application；Chinese patent literature CN102698043B discloses a kind of pharmaceutical composition for treating thyroid disease, by frankincense, does not have
Medicine, catechu, keel, dragon's blood, borneol, cape jasmine, the capsule of weeping forsythia, pseudo-ginseng, safflower, Fructus Aurantii, balloonflower root, radix scrophulariae, radix cyathulae and moutan bark composition；
Chinese patent literature CN103191306B discloses a kind of external application of Chinese medicine medicine for treating thyroid nodule, by common calanthe herb,
Acuteleaf caper root, cicada's wings rattan, virginia grape fern herb with root, trifoliate orange, spiral shell, bryozoatum, Rhizoma soulieae vaginatae are made；Chinese patent literature
CN103191306B discloses a kind of Chinese medicine for treating autoimmune thyroiditis, by Chinese medicine radix bupleuri, fritillaria thunbergii, Poria cocos,
Radix Angelicae Sinensis and curcuma zedoary are made, with dispersing liver and promoting blood circulation, the features such as resolving phlegm and softening hard masses dissipating bind；Chinese patent literature CN102018928B is disclosed
A kind of Chinese medicine composition for treating hypothyroidism, by radix bupleuri, rhizoma cyperi, the banksia rose, the root of three-nerved spicebush, orange peel, rascal, the dried immature fruit of citron orange, thickness
Piao, fructus amomi, Amomum cardamomum, cultivated land, stir-baked RHIZOMA DIOSCOREAE, the fruit of Chinese wolfberry, Semen Cuscutae, the bark of eucommia, Fructus Corni, Radix Angelicae Sinensis, monkshood, Chinese cassia tree, kelp, sea
Algae, blood clam and the taste Chinese medicine of sea clam 23 are made；Chinese patent literature CN101884769B disclose it is a kind of by radix bupleuri, fritillaria thunbergii,
Poria cocos, Radix Angelicae Sinensis, the composition of the taste Chinese medicine of curcuma zedoary 5 composition.
From above-mentioned document, generally there is obvious liver in the medicine of current western medical treatment autoimmune thyroiditis
The side effects such as damage, generally require additionally to take protection medicine, reduce the harm to patient；Chinese medicine LADA first
The medicine of shape adenositis has significant curative effect, and security is higher, and its prescription complicated mechanism is various, has the following disadvantages：
1）Chinese medicine compound prescription is prepared by 10~40 taste raw medicinal materials more, and medicine variety is more, and effective substance is indefinite, therefore mostly
Number can only be using oral administration, and the drug bioavailability being administered orally is relatively low, causes the waste of herb resource；
2）The Chinese medicine compound prescription of autoimmune thyroiditis is treated at present, and only a few can be prepared by 5 taste raw medicinal materials, but also
There is effective substance unstructured problem, and be only prepared into oral preparation drug administration, bioavilability is relatively low；
3）The Chinese medicine compound prescription for the treatment of autoimmune thyroiditis at present, only a few can be prepared into liniment, but for
Drug releasing rate and drugloading rate etc. consider, are only capable of being prepared into simple pasty mixture coating affected part, this drug adhesion power
Not strong, patient's administration is inconvenient, and influences attractive in appearance, and patient compliance is poor.
The content of the invention
For above-mentioned prior art, an object of the present invention is to provide a kind of treat in autoimmune thyroiditis
Medicine cataplasm.To realize above-mentioned purpose, the technical solution adopted by the present invention is：
In a kind of Chinese medicine patcher for treating autoimmune thyroiditis, the treatment autoimmune thyroiditis
The active component of medicine cataplasm is made up of the raw medicinal material of following weight part ratio：The parts by weight of fritillaria thunbergii 45~55, Chinese yam 15~25
Parts by weight, the parts by weight of Radix Isatidis 5~10, the parts by weight of Flos Albiziae 8~15, the parts by weight of Haiti melon 5~10.
It is used as the further optimization of technical solution of the present invention, the Chinese medicine patcher of the treatment autoimmune thyroiditis
Active component be made up of the raw medicinal material of following weight part ratio：The parts by weight of fritillaria thunbergii 50, the parts by weight of Chinese yam 22, the weight of Radix Isatidis 9
Measure part, the parts by weight of Flos Albiziae 12, the parts by weight of Haiti melon 6.
Another aspect of the present invention additionally provides the preparation of the Chinese medicine patcher of above-mentioned treatment autoimmune thyroiditis
Method, comprises the following steps：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 2~8g/mL, obtain raw medicinal material medicinal extract；
6）The Acritamer 940 for taking weight to be 0.07~0.1 times of raw medicinal material gross weight, is added in 10 times of amount purified waters,
Stand overnight, it is 7 to add pH adjusting agent adjustment pH, is used as A phases；
7）The sodium carboxymethylcellulose for taking weight to be 0.1~0.14 times of raw medicinal material gross weight, is added to 7 times of amount purified waters
In be fully swelled, add diatomite, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stirring
Uniformly it is used as B phases；
8）Take step 5）Gained raw medicinal material medicinal extract adds polyethylene glycol 200, glycerine and stirred, and is used as C phases；
9）A is added in B phases, as D phases after stirring, C is added in D phases, is coated with after stirring
In back lining materials, coating thickness is 0.5~0.8mm, is capped nonadherent protective layer, be cut into specification be long 1~4 cm, it is wide by 0.8~
2 cm rectangle, packing produces the Chinese medicine patcher for the treatment of autoimmune thyroiditis.
It is used as the further optimization step 6 of technical solution of the present invention）Middle pH adjusting agent is NaOH；The step 7）In
Diatomite, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, the consumption of decyl methyl sulfoxide are followed successively by raw medicinal material
0.18~0.22 times, 0.003~0.006 times, 0.005~0.008 times, 0.1~0.12 times, 0.09~0.12 times of gross weight；
The step 8）Middle polyethylene glycol 200, the consumption of glycerine be followed successively by 0.07~0.1 times of raw medicinal material gross weight, 0.1~0.15
Times；The step 9）Middle rectangle specification is wide 1 cm of long 2 cm.
It is used as the further optimization of technical solution of the present invention, the step 7）Middle diatomite, dihydroxy aluminum glycinate, lemon
Acid, polyvinylpyrrolidone, the consumption of decyl methyl sulfoxide be followed successively by 0.2 times of raw medicinal material gross weight, 0.005 times, 0.007
Again, 0.105 times, 0.1 times；The step 8）Middle polyethylene glycol 200, the consumption of glycerine are followed successively by the 0.08 of raw medicinal material gross weight
Again, 0.12 times.
It is used as the further optimization of technical solution of the present invention, the step 9）Middle back lining materials are non-woven fabrics；The step
9）Middle nonadherent protective layer is polyethylene film.
Term used in technical solution of the present invention " raw medicinal material " is also known as Chinese medicine, and this is known to one of skill in the art
's.
Term used in technical solution of the present invention " raw medicinal material gross weight " be the Chinese medicine used in prescription weight it
With this is known in those skilled in the art.
Term used in technical solution of the present invention " solid-liquid ratio " refers to the quality and " liquid " as extract solution of " material " of solid-state
Volume ratio.The metering list of the solid-liquid ratio when extract solution consumption is described using solid-liquid ratio in prepared by the extraction of raw medicinal material
Position is g：ML, such as solid-liquid ratio are 1:7, as 1g raw medicinal materials add 7mL extract solutions, and this belongs to those skilled in the art
Common technical knowledge.
" fritillaria thunbergii " described in technical solution of the present invention is liliaceous plant fritillaria thunbergii Fritillaria thunbergii
Miq. dry bulb, this is known in those skilled in the art.
" Chinese yam " described in technical solution of the present invention is Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb.
Dry rhizome, this is known in those skilled in the art.
" Radix Isatidis " described in technical solution of the present invention is cruciferae isatis Isatis indigotica Fort.
Dry root, this is known in those skilled in the art.
" Flos Albiziae " described in technical solution of the present invention is legume silk tree Albizia julibrissin Durazz.
Drying inflorescence, this is known in those skilled in the art.
" Haiti melon " described in technical solution of the present invention, is Echinodermata（Echinodermata）Holothuroidea
（Holothuroidea）, Molpadida（Molpadida）Kao Can sections（Caudinidae）, Acaudina（Acaudina）Animal.This
It is known in those skilled in the art.
" coating thickness " described in technical solution of the present invention refers to the medicated layer thickness for being coated on back lining materials, and this is ability
Well known to field technique personnel.Selection and drugloading rate ability relevant this of the coating thickness with excipient substance are those skilled in the art
Known.Usual coating thickness can be adjusted by the adjusting means of coating apparatus, and artificial scraper type coating and roller are applied
The coating thickness of cloth can be by thickness measuring Instrument measuring, and this is known in those skilled in the art.
The present inventor is found surprisingly that in research process, by fritillaria thunbergii, Chinese yam, Radix Isatidis, Flos Albiziae, Haiti
The traditional Chinese compound medicine that melon is constituted according to a certain percentage has therapeutic effect beyond expectation to autoimmune thyroiditis.Should
Compound medicine is prepared into the skin that neck thyroid gland correspondence position is affixed on after Chinese medicine patcher, and energy Transdermal absorption is quickly reached
Thyroid gland plays preferable drug effect.And medicinal material used in the compound medicine is less, Chinese medicine patcher drugloading rate is prepared greatly, can be by bar
Cloth agent cuts into less area, realizes precisely administration.Cataplasm only can be affixed on people for the patient of unilateral Thyroid Gland Swell
Cataplasm, neck pair can be affixed on respectively for the patient of bilateral Thyroid Gland Swell by body neck Ipsilateral thyroid gland correspondence position
Side thyroid gland correspondence position.The Chinese medicine patcher of the treatment autoimmune thyroiditis of the present invention can be cut greatly due to drugloading rate
Into less area, paste convenient, it is relatively small to patient's aesthetic effects, the compliance of patient can be improved, is conducive to clinical answer
With.
Embodiment
The present invention is further explained with reference to embodiment.It should be appreciated that following examples are only used for solution
The present invention is released, rather than is limited the scope of the invention.
The Chinese medicine patcher of the treatment autoimmune thyroiditis of embodiment 1 and its preparation
Raw medicinal material：Fritillaria thunbergii 500g, Chinese yam 220g, Radix Isatidis 90g, Flos Albiziae 120g, Haiti melon 60g.
Pharmaceutic adjuvant：Acritamer 940 79.2g, sodium carboxymethylcellulose 118.8g, diatomite 198g, dihydroxy glycine
Aluminium 4.95g, citric acid 6.93g, polyvinylpyrrolidone 103.95, decyl methyl sulfoxide 99g, polyethylene glycol 200 79.2g are sweet
Oily 118.8g.
Preparation method：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 7g/mL, obtain raw medicinal material medicinal extract；
6）Take Acritamer 940 to be added in 10 times of amount purified waters, stand overnight, it is 7 to add NaOH regulations pH, is used as A
Phase；
7）Sodium carboxymethylcellulose is taken, is added in 7 times of amount purified waters and is fully swelled, add diatomite, the sweet ammonia of dihydroxy
Sour aluminium, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phases；
8）Take step 5）Gained raw medicinal material medicinal extract adds polyethylene glycol 200, glycerine and stirred, and is used as C phases；
9）A is added in B phases, as D phases after stirring, C is added in D phases, is coated with after stirring
In non-woven fabrics, coating thickness is 0.7mm, is capped polyethylene film, is cut into wide 1 cm of a length of 2 cm of specification rectangle, point
Dress, produces the Chinese medicine patcher for the treatment of autoimmune thyroiditis.
The Chinese medicine patcher of the treatment autoimmune thyroiditis of embodiment 2 and its preparation
Raw medicinal material：Fritillaria thunbergii 540g, Chinese yam 180g, Radix Isatidis 70g, Flos Albiziae 90g, Haiti melon 90g.
Pharmaceutic adjuvant：Acritamer 940 87.3g, sodium carboxymethylcellulose 126.1g, diatomite 203.7g, the sweet ammonia of dihydroxy
Sour aluminium 3.88g, citric acid 5.82g, polyvinylpyrrolidone 106.7, decyl methyl sulfoxide 106.7, polyethylene glycol 200
87.3g, glycerine 135.8g.
Preparation method：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 5g/mL, obtain raw medicinal material medicinal extract；
6）Take Acritamer 940 to be added in 10 times of amount purified waters, stand overnight, it is 7 to add NaOH regulations pH, is used as A
Phase；
7）Sodium carboxymethylcellulose is taken, is added in 7 times of amount purified waters and is fully swelled, add diatomite, the sweet ammonia of dihydroxy
Sour aluminium, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phases；
8）Take step 5）Gained raw medicinal material medicinal extract adds polyethylene glycol 200, glycerine and stirred, and is used as C phases；
9）A is added in B phases, as D phases after stirring, C is added in D phases, is coated with after stirring
In non-woven fabrics, coating thickness is 0.6mm, is capped polyethylene film, is cut into wide 1 cm of a length of 3 cm of specification rectangle, point
Dress, produces the Chinese medicine patcher for the treatment of autoimmune thyroiditis.
The Chinese medicine patcher of the treatment autoimmune thyroiditis of embodiment 3 and its preparation
Raw medicinal material：Fritillaria thunbergii 460g, Chinese yam 200g, Radix Isatidis 60g, Flos Albiziae 140g, Haiti melon 70g.
Pharmaceutic adjuvant：Acritamer 940 74.4g, sodium carboxymethylcellulose 102.3g, diatomite 176.7g, the sweet ammonia of dihydroxy
Sour aluminium 3.72g, citric acid 6.51g, polyvinylpyrrolidone 102.3, decyl methyl sulfoxide 97.65, polyethylene glycol 200
69.8g, glycerine 102.3g.
Preparation method：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 3g/mL, obtain raw medicinal material medicinal extract；
6）Take Acritamer 940 to be added in 10 times of amount purified waters, stand overnight, it is 7 to add NaOH regulations pH, is used as A
Phase；
7）Sodium carboxymethylcellulose is taken, is added in 7 times of amount purified waters and is fully swelled, add diatomite, the sweet ammonia of dihydroxy
Sour aluminium, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phases；
8）Take step 5）Gained raw medicinal material medicinal extract adds polyethylene glycol 200, glycerine and stirred, and is used as C phases；
9）A is added in B phases, as D phases after stirring, C is added in D phases, is coated with after stirring
In non-woven fabrics, coating thickness is 0.6mm, is capped polyethylene film, is cut into wide 1 cm of a length of 3 cm of specification rectangle, point
Dress, produces the Chinese medicine patcher for the treatment of autoimmune thyroiditis.
The Chinese medicine patcher of the treatment autoimmune thyroiditis of embodiment 4 and its preparation
Raw medicinal material：Fritillaria thunbergii 500g, Chinese yam 220g, Radix Isatidis 90g, Flos Albiziae 120g, Haiti melon 60g.
Pharmaceutic adjuvant：Acritamer 940 79.2g, sodium carboxymethylcellulose 118.8g, diatomite 198g, dihydroxy glycine
Aluminium 4.95g, citric acid 6.93g, polyvinylpyrrolidone 103.95, decyl methyl sulfoxide 99g, polyethylene glycol 200 79.2g are sweet
Oily 118.8g.
Preparation method：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 5g/mL, obtain raw medicinal material medicinal extract；
6）Take Acritamer 940 to be added in 10 times of amount purified waters, stand overnight, it is 7 to add NaOH regulations pH, is used as A
Phase；
7）Sodium carboxymethylcellulose is taken, is added in 7 times of amount purified waters and is fully swelled, add diatomite, the sweet ammonia of dihydroxy
Sour aluminium, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phases；
8）Take step 5）Gained raw medicinal material medicinal extract adds polyethylene glycol 200, glycerine and stirred, and is used as C phases；
9）A is added in B phases, as D phases after stirring, C is added in D phases, is coated with after stirring
In stretch fabric, coating thickness is 0.7mm, is capped polyethylene film, is cut into wide 1 cm of a length of 2 cm of specification rectangle, point
Dress, produces the Chinese medicine patcher for the treatment of autoimmune thyroiditis.
The Chinese medicine patcher of the treatment autoimmune thyroiditis of embodiment 5 and its preparation
Raw medicinal material：Fritillaria thunbergii 540g, Chinese yam 180g, Radix Isatidis 70g, Flos Albiziae 90g, Haiti melon 90g.
Pharmaceutic adjuvant：Acritamer 940 87.3g, sodium carboxymethylcellulose 126.1g, diatomite 203.7g, the sweet ammonia of dihydroxy
Sour aluminium 3.88g, citric acid 5.82g, polyvinylpyrrolidone 106.7, decyl methyl sulfoxide 106.7, polyethylene glycol 200
87.3g, glycerine 135.8g.
Preparation method：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 7g/mL, obtain raw medicinal material medicinal extract；
6）Take Acritamer 940 to be added in 10 times of amount purified waters, stand overnight, it is 7 to add NaOH regulations pH, is used as A
Phase；
7）Sodium carboxymethylcellulose is taken, is added in 7 times of amount purified waters and is fully swelled, add diatomite, the sweet ammonia of dihydroxy
Sour aluminium, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir as B phases；
8）Take step 5）Gained raw medicinal material medicinal extract adds polyethylene glycol 200, glycerine and stirred, and is used as C phases；
9）A is added in B phases, as D phases after stirring, C is added in D phases, is coated with after stirring
In spun laced fabric, coating thickness is 0.6mm, is capped polyethylene film, is cut into wide 1 cm of a length of 3 cm of specification rectangle, point
Dress, produces the Chinese medicine patcher for the treatment of autoimmune thyroiditis.
The pharmacodynamic study of the Chinese medicine patcher of the treatment autoimmune thyroiditis of embodiment 6
It is special in verify the drug effect and advantage of the Chinese medicine patcher for treating autoimmune thyroiditis of the invention
3 kinds of medicine compound contrast agents, its preparation method is as follows：
The first contrast agents（Contrast 1）The medicinal extract prepared for the raw medicinal material extract solution of embodiment 1, prescription and preparation method
It is as follows：
Raw medicinal material：Fritillaria thunbergii 500g, Chinese yam 220g, Radix Isatidis 90g, Flos Albiziae 120g, Haiti melon 60g.
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 14g/mL, obtain raw medicinal material medicinal extract.
Second of contrast agents（Contrast 2）To implement medicinal extract prepared by 2 raw medicinal material extract solutions, prescription and preparation method are such as
Under：
Raw medicinal material：Fritillaria thunbergii 540g, Chinese yam 180g, Radix Isatidis 70g, Flos Albiziae 90g, Haiti melon 90g.
Preparation method：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 14g/mL, obtain raw medicinal material medicinal extract.
The third contrast agents（Contrast 3）To implement medicinal extract prepared by 3 raw medicinal material extract solutions, prescription and preparation method are such as
Under：
Raw medicinal material：Fritillaria thunbergii 460g, Chinese yam 200g, Radix Isatidis 60g, Flos Albiziae 140g, Haiti melon 70g.
Preparation method：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder is added at the ethanol that concentration is 70%, 60 DEG C
Water bath with thermostatic control refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:3 ratio adds concentration
For 70% ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:7 ratio adds concentration
75% ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, silk tree
Flower mixed extract；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, and makes extract concentration according to medicinal material gross weight/carry
Take liquid product to be calculated as 14g/mL, obtain raw medicinal material medicinal extract.
In addition to above-mentioned self-control contrast agents, Tripterygium wilfordii Polyglycosidium Tablets are separately set（Xieli Pharmaceutical Co., Ltd., Hunan produces）As right
Compare medicament（Contrast 4）.
Test method and result are as follows：
Regular grade Healthy female SD rats, by Heilongjiang University of Chinese Medicine, animal experimental center is provided, body weight 140~
210g.After adaptability is raised 2 weeks, rat 80 is taken at random, is randomly divided into 8 groups, 1-7 groups are administration model group, and the 8th group is just
Often group not modeling is not administered.
The preparation of complete Freund's adjuvant and incomplete Freund's adjuvant antigen (PTg) emulsion:
PTg normal salines are taken into the solution of 0. 1% concentration.Again by itself and Split completely（Purchased from GIBCO
Company）Or incomplete freund adjuvant（Purchased from GIBCO companies）By 1：1 (V/V) is mixed, and water-in-oil emulsion, every milliliter is made
Contain 0. 5 mg PTg in emulsion.
ML (the μ containing PTg100 of complete Freund's adjuvant antigen emulsion 0. 2 are subcutaneously injected in 1-7 groups rat difference back multiple spot
G) initial immunity is carried out, with the incomplete mL booster immunizations of freund adjuvant antigen emulsion 0. 2 after 2 weeks, strengthens weekly exempting from later
Epidemic disease 1 time, terminated immune, the 8th group of Normal group does not do modeling processing to the 6th week.
After modeling success, each group dosage and frequency are as follows：
1-3 group rats：With scissors or electric shaver removing neck mouse hair after anesthesia, skin of neck is coated with 8%Nas,
Cleaned up repeatedly with warm water.1st group of rat sticks the cataplasm of the preparation of embodiment 1, cataplasm face in neck thyroid gland position
Product is 2x1cm2.Paste 1 dose within every 3 days（1 note）, common note 27 days.2nd group of rat sticks embodiment 2 in neck thyroid gland position and prepared
Cataplasm, cataplasm area be 2x1cm2.Paste 1 dose within every 3 days（1 note）, common note 27 days.3rd group of rat is in neck thyroid gland portion
Position, which is sticked, implements 3 cataplasms prepared, and cataplasm area is 2x1cm2.Paste 1 dose within every 3 days（1 note）, common note 27 days.
Gavage gives contrast 1, contrast 2,3 three kinds of contrast agents of contrast, daily gastric infusion one to 4-6 groups rat respectively
Secondary, each gavage gives 2mL raw medicinal material medicinal extract, is administered 27 days altogether.7th group of rat oral gavage gives the contrast agents of contrast 4（Thunder
The public many glycosides pieces of rattan）Water mix liquid, dosage is calculated as 20mg/kg according to tripterygium glycosides, and daily gastric infusion once, is given altogether
Medicine 27 days.8th group of rat not modeling is not administered.
The 3rd after each group rat is administered, 6,12,27 days, retroorbital venous clump blood sampling 3mL separates serum（-80℃
Freeze standby）.Take and thawed under the rat blood serum frozen, normal temperature, by TGAb, TPOAb radiommunoassay reagent
Box（Purchased from Beijing Fu Rui bio-engineering corporations）Detecting step carries out TGAb, TPOA b and determined.As a result 1, table 2 is shown in Table respectively.
The each group rat blood serum TGAb tables of data of table 1
1:The p ＜ 0.05 compared with the 7th group；2:The p ＜ 0.05 compared with the 8th group.
4-7 groups are substantially less than within the 6th day after table 1,1,2,3 groups of rat blood serum TGAb self administration of medication, wherein the 1st group
Rat upon administration the 27th day serum TG Ab and the 8th group without significant difference, point out the treatment Autoimmune Thyroid of the present invention
Scorching Chinese medicine patcher has good therapeutic effect to autoimmune thyroiditis, and drug effect plays speed and is significantly faster than mouth
Take drug-delivery preparation.
The each group rat blood serum TPOAb tables of data of table 2
4-7 groups are substantially less than within the 3rd day after table 2,1,2,3 groups of rat blood serum TPOAb self administration of medication, wherein the 1st
Group rat upon administration the 27th day serum TG Ab and the 8th group without significant difference, point out treatment LADA first shape of the invention
The Chinese medicine patcher of adenositis has good therapeutic effect to autoimmune thyroiditis, and drug effect plays speed and is significantly faster than
Oral Preparation.
By table 1, the visible Chinese medicine patcher for treating autoimmune thyroiditis of the invention of table 2 to LADA first
Shape adenositis has good therapeutic effect, has compared with the Tripterygium wilfordii Polyglycosidium Tablets of verified determined curative effect with present significantly excellent
Gesture, has the advantages that rapid delivery of pharmaceuticals plays rapidly drug effect, Transdermal absorption effect is good, with good clinical value.
Claims (5)
1. a kind of Chinese medicine patcher for treating autoimmune thyroiditis, it is characterised in that the treatment LADA first
The active component of the Chinese medicine patcher of shape adenositis is made up of the raw medicinal material of following weight part ratio：The parts by weight of fritillaria thunbergii 45~55,
The parts by weight of Chinese yam 15~25, the parts by weight of Radix Isatidis 5~10, the parts by weight of Flos Albiziae 8~15, the parts by weight of Haiti melon 5~10；It is described to control
The preparation method for treating the Chinese medicine patcher of autoimmune thyroiditis comprises the following steps：
1）Take Chinese yam to remove the peel, be cut into after being dried at the thin slice that thickness is 2mm, 50 DEG C and crush, cross 100 mesh sieves, obtain yam flour；
2）It is 1 according to solid-liquid ratio:6 ratio is to step 1）Gained medicinal powder adds constant temperature at the ethanol that concentration is 70%, 60 DEG C
Water-bath refluxing extraction 4h, filters, obtains Chinese yam extract while hot；
3）Take Haiti melon to remove the internal organs, clean and dried at draining, 30 DEG C, be 1 according to solid-liquid ratio:It is 70% that 3 ratio, which adds concentration,
Ethanol, extracting at constant temperature 10h at 50 DEG C filters to obtain extra large pachyrhizus extract；
4）Take fritillaria thunbergii, Radix Isatidis, Flos Albiziae to crush, cross 80 mesh sieves, be 1 according to solid-liquid ratio:It is 75% that 7 ratio, which adds concentration,
Ethanol, water bath with thermostatic control refluxing extraction 3 times at 90 DEG C, each 3h mixes extract solution, obtains fritillaria thunbergii, Radix Isatidis, Flos Albiziae and mixes
Close extract solution；
5）By step 2）、3）、4）Gained extract solution is mixed, and is concentrated under reduced pressure, is made extract concentration according to medicinal material gross weight/extract solution
Volume is calculated as 2~8g/mL, obtains raw medicinal material medicinal extract；
6）The Acritamer 940 for taking weight to be 0.07~0.1 times of raw medicinal material gross weight, is added in 10 times of amount purified waters, stands
Overnight, it is 7 to add pH adjusting agent adjustment pH, is used as A phases；
7）The sodium carboxymethylcellulose for taking weight to be 0.1~0.14 times of raw medicinal material gross weight, is added in 7 times of amount purified waters and fills
Divide and be swelled, add diatomite, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, decyl methyl sulfoxide, stir
It is used as B phases；
8）Take step 5）Gained raw medicinal material medicinal extract adds polyethylene glycol 200, glycerine and stirred, and is used as C phases；
9）A is added in B phases, as D phases after stirring, C is added in D phases, the back of the body is coated on after stirring
Lining material, coating thickness is 0.5~0.8mm, is capped nonadherent protective layer, and it is long 1~4 cm, wide 0.8~2 cm to be cut into specification
Rectangle, packing, produce treatment autoimmune thyroiditis Chinese medicine patcher.
2. the Chinese medicine patcher for the treatment of autoimmune thyroiditis according to claim 1, it is characterised in that described to control
The active component for treating the Chinese medicine patcher of autoimmune thyroiditis is made up of the raw medicinal material of following weight part ratio：Fritillaria thunbergii
50 parts by weight, the parts by weight of Chinese yam 22, the parts by weight of Radix Isatidis 9, the parts by weight of Flos Albiziae 12, the parts by weight of Haiti melon 6.
3. the Chinese medicine patcher for the treatment of autoimmune thyroiditis according to claim 1, it is characterised in that the step
Rapid 6）Middle pH adjusting agent is NaOH；The step 7）Middle diatomite, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone,
The consumption of decyl methyl sulfoxide be followed successively by 0.18~0.22 times of raw medicinal material gross weight, 0.003~0.006 times, 0.005~
0.008 times, 0.1~0.12 times, 0.09~0.12 times；The step 8）Middle polyethylene glycol 200, the consumption of glycerine are followed successively by raw material
0.07~0.1 times, 0.1~0.15 times of medicinal material gross weight；The step 9）Middle rectangle specification is wide 1 cm of long 2 cm.
4. the Chinese medicine patcher for the treatment of autoimmune thyroiditis according to claim 3, it is characterised in that the step
Rapid 7）Middle diatomite, dihydroxy aluminum glycinate, citric acid, polyvinylpyrrolidone, the consumption of decyl methyl sulfoxide are followed successively by original
Expect medicinal material gross weight 0.2 times, 0.005 times, 0.007 times, 0.105 times, 0.1 times；The step 8）It is middle polyethylene glycol 200, sweet
The consumption of oil is followed successively by 0.08 times of raw medicinal material gross weight, 0.12 times.
5. the Chinese medicine patcher of the treatment autoimmune thyroiditis according to claim 3 or 4, it is characterised in that institute
State step 9）Middle back lining materials are non-woven fabrics；The step 9）Middle nonadherent protective layer is polyethylene film.
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| CN101690818A (en) * | 2009-09-22 | 2010-04-07 | 苏州恒星医用材料有限公司 | Cataplasm matrix and preparation method thereof |
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| CN101690818A (en) * | 2009-09-22 | 2010-04-07 | 苏州恒星医用材料有限公司 | Cataplasm matrix and preparation method thereof |
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| CN101884769A (en) * | 2010-07-08 | 2010-11-17 | 辽宁中医药大学 | Traditional Chinese medicine for treating autoimmune thyroiditis and production method |
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