CN104510888A - Water lily panting-calming cough-relieving syrup and preparation method thereof - Google Patents

Water lily panting-calming cough-relieving syrup and preparation method thereof Download PDF

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CN104510888A
CN104510888A CN201310447839.5A CN201310447839A CN104510888A CN 104510888 A CN104510888 A CN 104510888A CN 201310447839 A CN201310447839 A CN 201310447839A CN 104510888 A CN104510888 A CN 104510888A
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cough
panting
syrup
preparation
teragona georgi
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李实�
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QINGDAO CHANGLYU BIOLOGICAL INSTITUTE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/78Saururaceae (Lizard's-tail family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention relates to a water lily panting-calming cough-relieving syrup and a preparation method thereof. The syrup is mainly composed of water lily, licorice, cordate houttuynia, fritillary bulb, almond, loquat leaf, brown sugar, sodium benzoate, and the like, is prepared by concentration and processing through a special technology, has the functions of clearing lung, relieving cough, removing phlegm, calming panting, regulating qi, and eliminating inflammation, and is used to treat cough caused by cold and panting caused by bronchitis or lung diseases. The invention belongs to the field of medicine and health care. Water lily is taken as the main component to calm panting and relieve cough, and at the same time is compounded with a plurality of traditional Chinese herbals in order to kill bacteria and eliminate inflammation quickly, eliminate pathogen that causes cold, relieve cough and asthma symptoms quickly, cure the cold quickly, promote the repair of damaged bronchial mucosa, and improve human immunity. The provided syrup has the advantages of long-lasting and stable curative effect, short treatment course, rapid effect, and treatment on roots and symptoms.

Description

Flos nymphaeae (Nymphaea teragona Georgi) antiasthmatic-antitussive syrup and preparation method thereof
technical fieldthe present invention relates to a kind of Flos nymphaeae (Nymphaea teragona Georgi) antiasthmatic-antitussive syrup and preparation method thereof.The main component of antiasthmatic-antitussive syrup is Flos nymphaeae (Nymphaea teragona Georgi), Radix Glycyrrhizae, Herba Houttuyniae, Bulbus Fritillariae Ussuriensis, Semen Armeniacae Amarum, Folium Eriobotryae, brown sugar, sodium benzoate etc., according to special process, concentrated processing extraction is made, there is effect of clearing away lung-heat to relieve cough, eliminating phlegm and relieving asthma, antiinflammatory of regulating the flow of vital energy, the cough caused for catching a cold, the cough with asthma that bronchitis, pulmonary disease cause.The technology of the present invention belongs to medicines and health protection field.Know-why of the present invention is the main component using Flos nymphaeae (Nymphaea teragona Georgi) as antiasthmatic-antitussive, and compatibility plurality of Chinese, rapid sterilization, antiinflammatory, remove the pathogen causing flu, rapid relieving cough, symptom out of breath of panting, rapid healing is caught a cold, and promotes the recovery of bronchial mucosa damaged part, improve body immunity, curative effect lasting stability.Short treating period, rapid-action, treating both the principal and secondary aspects of a disease.
background technologycough (Cough) is a kind of protectiveness respiratory reflex action of human body.Effectively can remove the secretions in respiratory tract by coughre flex or enter the foreign body of air flue.Cause the reason of cough more, have several what time lower: one is too urgent, satiety of having a meal: this situation is more common in daily life, we often eat a bite meal, air all can enter in our abdomen with food,, satiety too urgent if had a meal, air can not be discharged timely, and phenomenon of having the hiccups, appears in the contraction that diaphragm flesh will be caused to can't help; Two is emotional instabilitys: when people are in stewed state, and health will increase the demand of oxygen, the air that the suction that people will be caused to can't help is too much, thus initiation is had the hiccups; Three is dyspepsias: gastrointestinal tract pneumatosis, hydrops are too much, wriggled, will cause and have the hiccups by gastrointestinal, helps to get rid of gas unnecessary in body; Four is disease factors: the disease such as chronic gastritis, Reflux exophagitis all can be had the hiccups phenomenon, and usually with abnormal flavour, patient should draw attention.
The traditional Chinese medical science thinks that cough is because of diseases caused by exogenous pathogenic factor six climate exopathogens, internal organs internal injury, affects the sound disease having expectorant caused by the lung.See " Plain Questions the five internal organs generate a section "." Plain Questions pathogenesis gas should save one's life collection ": " cough meaning sound without expectorant, lung qi is hindered and also unclear; It is noiseless and have expectorant for coughing, spleen wet dynamic and be expectorant also.Cough meaning has expectorant and sound, and lid moves in lung qi due to wound and wets in spleen, cough and for coughing also ".Cough but no phlegm or amount of expectoration are seldom dry cough, are common in acute pharyngolaryngitis, bronchitic initial stage; The acute cough suddenly occurred, is more common in foreign body in bronchus; Long-term chronic is coughed, and is more common in chronic bronchitis, pulmonary tuberculosis etc.The detrimental effect of cough, is trachea pathological changes can be diffused into contiguous bronchia, aggravates disease.In addition, cough violent lastingly can affect rest, goes back easy consumption muscle power, and can cause the destruction of alveolar wall Elastic tissue, brings out emphysema.
Flos nymphaeae (Nymphaea teragona Georgi) rhizome rich in starch, edible or wine brewing.Herb should make green manure, its root stock edible or medicinal.Rhizome also can be used as medicine, and for doing analeptic, astringent, can be used for treating nephritis, also having a function such as blood pressure lowering removing heat from blood, hidroschesis antitussive.The present invention is using Flos nymphaeae (Nymphaea teragona Georgi) as the main component of antiasthmatic-antitussive, and compatibility plurality of Chinese, rapid sterilization, antiinflammatory, remove the pathogen causing flu, rapid relieving cough, symptom out of breath of panting, rapid healing is caught a cold, and promotes the recovery of bronchial mucosa damaged part, improve body immunity, curative effect lasting stability.Short treating period, rapid-action, treating both the principal and secondary aspects of a disease.In addition, the present invention can also general equilibrium act on lesions position and systemic organs, conditioning viscera function and body immune Force system, can the body of being sunk into sleep be activated, improve body constitution especially, treatment minor illness, chronic disease, prevention major disease aspect advantage clearly.
summary of the inventionmain points of the present invention are to provide a kind of main component using Flos nymphaeae (Nymphaea teragona Georgi) as antitussive, and the Compound Chinese Herbs for Fatigue-Resistance of Animal of the multiple natural Chinese medicine of compatibility, rapid sterilization, antiinflammatory, remove the pathogen causing flu, rapid relieving cough, symptom out of breath of panting, rapid healing is caught a cold, and promotes the recovery of bronchial mucosa damaged part, improve body immunity, curative effect lasting stability.
The formula that the present invention selects following (component and percentage by weight % thereof): Flos nymphaeae (Nymphaea teragona Georgi) 10.0-15.0, Radix Glycyrrhizae 5.0-10.0,
Herba Houttuyniae 5.0-10.0, Bulbus Fritillariae Ussuriensis 5.0-10.0, Semen Armeniacae Amarum 1.0-5.0, Folium Eriobotryae 1.0-5.0, brown sugar 5.0-10.0, sodium benzoate 0.1-1.0, water adds to 100.
Flos nymphaeae (Nymphaea teragona Georgi) is also known as water lily, Herba Oenanthes Javanicae, and be the perennial water plant belonging to Nymphaeceae Nymphaea, Flos nymphaeae (Nymphaea teragona Georgi) is rare flower in flowering marsh plants.External form is similar to Flos Nelumbinis, goes out the water surface unlike the leaf of Flos Nelumbinis and Hua Ting, and the leaf of Flos nymphaeae (Nymphaea teragona Georgi) and flower float on the surface.Flos nymphaeae (Nymphaea teragona Georgi) is described as " spending middle sleeping beauty " because relax daytime rolls up at night.The purposes of Flos nymphaeae (Nymphaea teragona Georgi) is very wide, can be used for eating, tea making, cut-flower, the purposes such as medicinal.The noxious substances such as the hydrargyrum in water, lead, phenol can be absorbed due to Flos nymphaeae (Nymphaea teragona Georgi) root, can also microorganism in filtered water, be the vegetable material of rare water body purification, so purify at urban water-body, afforest, beautify in construction and extremely pay attention to.Flos nymphaeae (Nymphaea teragona Georgi) rhizome rich in starch, edible or wine brewing.Herb should make green manure, its root stock edible or medicinal.Rhizome also can be used as medicine, and for doing analeptic, astringent, can be used for treating nephritis, also having a function such as blood pressure lowering removing heat from blood, hidroschesis antitussive.
Radix Glycyrrhizae property is put down, and sweet in the mouth, returns 12 warps.There is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency is detoxified, and is in harmonious proportion hundred medicines.Clinical practice divides, and " life is used " is not with " processed with honey ".Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin, weak heating and cough, cardiopalmus etc.Radix Glycyrrhizae is used for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc.The former, normal and Ramulus Cinnamomi compatibility, as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter, is often equal to use with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, as ball in decoction of four noble drugs, reason etc.For asthma and cough.Can be alone, also can the application of compatibility other drug.As controlled the ERCHEN TANG of cough due to damp-phlegm; Control the Linggan Wuwei Jiangxin Tang of cold-phlegm cough with asthma; Control the sangxing decoction of dry stool phlegm cough; Control pyretic toxicity and cause lung abscess cough and spit and to smell as of rotten fish the Radix Platycodonis decoction of purulent sputum; Control the Gancao Ganjiang soup etc. of cough and spit saliva foam.The also Chang Peiwu application of another cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough.For ulcer sores, laryngopharynx swelling and pain etc.Can be alone, for oral administration or external application, or compatibility application.Ulcer sores, is often equal to use with Flos Lonicerae, Fructus Forsythiae, plays the merit of heat-clearing and toxic substances removing altogether, as Xian fang Huoming Yin.Laryngopharynx swelling and pain, the normal and same use of Radix Platycodonis, as Radix Platycodonis decoction.
Herba Houttuyniae, another name Cen grass, Ji, purple Ji, Herba Houttuyniae, wild flower wheat etc. are the whole herb with root of saururaceae plant houttuynia cordata.Herba Houttuyniae has antibacterial action.Contained houttuynine sodium bisulfite, lauryl aldehyde, methyl n nonyl ketone, fragrant ethylene and the volatile oil component such as quercitrin, cordarine in Herba Houttuyniae, all have certain inhibitory action to staphylococcus aureus, Staphylococcus albus, dysentery bacterium, bacillus pyocyaneus, Bacillus proteus, paracolon, Grain-positive bacillus cereus etc., to staphylococcus aureus and Staphylococcus albus effect stronger.Modern multiplexly control lung abscess, pneumonia, acute and chronic tracheitis, urinary tract infection etc.Modern pharmacology experiment shows, these product have the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, upper respiratory tract infection, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, pulmonary carcinoma, cervical erosion, suppurative arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitisshock, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurative otitis media, mumps, pimple shape urticaria, chronic pharyngitis, anorectal disease, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.
Bulbus Fritillariae Ussuriensis is the dry bulb of liliaceous plant Bulbus Fritillariae Ussuriensis, has another name called level ground shellfish, Bulbus Fritillariae Uninbracteatae, flat shellfish.Nature and flavor are bitter, sweet, are slightly cold.Return lung, heart channel.Bulbus Fritillariae Ussuriensis extractum has central inhibitory action to experimental animal models.Bulbus Fritillariae Ussuriensis total alkaloids, pingpeimine A all have and significantly eliminate the phlegm and hypotensive activity." book on Chinese herbal medicine converge with speech ": " Bulbus Fritillariae Uninbracteatae, dissipating depression of QI, the therapeutic method to keep the adverse QI flowing downwards, the medicine that reduces phlegm are also.Lung moistening expectorant, relieving cough and relieving asthma, the then card of asthenia fire knot, Bulbus Fritillariae Uninbracteatae specially takes charge of first dose.Therefore join the Rhizoma Anemarrhenae, can clearing heat in QI system YIN nourishing; Join a kind of reed mentioned in ancient books, connecting can clearing away phlegm pathogenic fire reducing; Join to join over sixty years of age can go to mend and do not gather; Join return, Chinese herbaceous peony can regulating QI and battalion; Stick up can resolving depression poison for accessory again, controls wart core under item; Join two old generation half summer grade, can tonifying the lung expectorant and middle pathogenic fire reducing person also.More than repairing use, must be wonderful with river person.If separate carbuncle poison, broken crux, disappear real expectorant, applies malignant boil, is good again with native person.The lightly seasoned property of right river person is excellent, and native person's bitter in the mouth is bad, and the two is to use respectively.”
The nutritional labeling such as Semen Armeniacae Amarum rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum.Wherein the content of carotene is only second to Fructus Mangifera Indicae in fruit, and Semen Armeniacae Amarum is called anticancer fruit by people.Semen Armeniacae Amarum contains abundant fatty oil, has the effect reducing cholesterol, and therefore, Semen Armeniacae Amarum has good effect to control cardiovascular system diseases; Chinese medicine theory is thought, Semen Armeniacae Amarum has effect of promoting the production of body fluid to quench thirst, lung moistening Dingchuan, is usually used in the dryness of the lung and the health care of patient and the treatment such as breathes with cough.Semen Armeniacae Amarum is also containing abundant flavonoid and polyphenol components, and this composition not only can reduce the content of cholesterol in human body, significantly can also reduce the initiation potential of heart disease and a lot of chronic disease.Semen Armeniacae Amarum has beauty functions, can promote skin microcirculation, makes the ruddy gloss of skin.Semen Armeniacae Amarum also has antitumor action, Semen Armeniacae Amarum antitumor action mainly owing to containing a kind of bioactive substance--amygdaloside in Semen Armeniacae Amarum, can enter the special killing cancer cell of blood, and not act on healthy cell, therefore can improve the symptom of patients with advanced cancer, extend patient's life cycle.Meanwhile, due to containing abundant carotene, therefore can antioxidation, prevent free radical from attacking cell, there is the effect of prophylaxis of tumours.
The hydrocyanic acid that amygdalin contained by Folium Eriobotryae is hydrolyzed generation in vivo has antitussive action.Water decoction or ethyl acetate extract eliminate the phlegm and antiasthmatic effect.Volatile oil contained by its leaf has slight phlegm-dispelling functions.Also have report to point out, Folium Eriobotryae antitussive action is strong, and phlegm-dispelling functions is poor.Folium Eriobotryae water decoction or ethyl acetate extract all have antibacterial action to white or staphylococcus aureus, Diplococcus pneumoniae, shigella flexneri.But someone thinks, Folium Eriobotryae without antibacterial action, and can stimulate the growth of staphylococcus aureus.Report is pointed out, Folium Eriobotryae ethanol merceration extract has antiinflammatory action to foot swelling local application caused by rat carrageenan, and warm macerating extract local application or gastric infusion, merceration extract gastric infusion are all without antiinflammatory action.
The preparation method of product of the present invention is:
1) Flos nymphaeae (Nymphaea teragona Georgi), Radix Glycyrrhizae, Herba Houttuyniae, Bulbus Fritillariae Ussuriensis, Semen Armeniacae Amarum, Folium Eriobotryae are mixed in proportion, and through grinding, soak one hour;
2), after big fire is heated to boiling, from boiling after 30 minutes, leach head and to boil medicine liquid;
3) add clear water again, continue slow fire and decoct, repeat 2) step 2 ~ 3 time, leach liquid of boiling medicine again;
4) collecting decoction, filters, adds brown sugar in proportion and be condensed into syrup;
5) sodium benzoate powder mix homogeneously is added;
6) sample immediately, after the assay was approved, subpackage, labeling, sealing.
The present invention has the following advantages:
(1) pure natural plant essential ingredient is refined, harmless to human non-toxic;
(2) sterilization, antiinflammatory rapidly, removes the pathogen causing flu, and rapid healing flu eliminates symptom;
(3) can Chinese impression of healing emit fast, rapid relieving cough, symptom out of breath of panting;
(4) promote the recovery of bronchial mucosa damaged part, improve body immunity, curative effect lasting stability;
(5) short treating period, rapid-action, treating both the principal and secondary aspects of a disease;
(6) the experiment proved that, active ingredient is stablized, persistent, long shelf-life.
detailed description of the invention:the present invention is described in further detail in conjunction with the embodiments in face:
Be configured according to data listed in Table (percentage by weight %) and described step thereof:
Formula one:
Flos nymphaeae (Nymphaea teragona Georgi) 10.0-12.0, Radix Glycyrrhizae 5.0-8.0, Herba Houttuyniae 5.0-8.0, Bulbus Fritillariae Ussuriensis 5.0-8.0, Semen Armeniacae Amarum 1.0-3.0, Folium Eriobotryae 1.0-3.0, brown sugar 5.0-8.0, sodium benzoate 0.1-1.0, water adds to 100.
Formula two:
Flos nymphaeae (Nymphaea teragona Georgi) 13.0-15.0, Radix Glycyrrhizae 8.0-10.0, Herba Houttuyniae 8.0-10.0, Bulbus Fritillariae Ussuriensis 5.0-8.0, Semen Armeniacae Amarum 1.0-3.0, Folium Eriobotryae 3.0-5.0, brown sugar 8.0-10.0, sodium benzoate 0.1-1.0, water adds to 100.
Formula three:
Flos nymphaeae (Nymphaea teragona Georgi) 12.0-14.0, Radix Glycyrrhizae 5.0-8.0, Herba Houttuyniae 8.0-10.0, Bulbus Fritillariae Ussuriensis 5.0-8.0, Semen Armeniacae Amarum 1.0-3.0, Folium Eriobotryae 1.0-3.0, brown sugar 5.0-8.0, sodium benzoate 0.1-1.0, water adds to 100.

Claims (2)

1. the present invention relates to a kind of Flos nymphaeae (Nymphaea teragona Georgi) antiasthmatic-antitussive syrup and preparation method thereof, it is characterized in that there is following formula (component and percentage by weight % thereof):: Flos nymphaeae (Nymphaea teragona Georgi) 10.0-15.0, Radix Glycyrrhizae 5.0-10.0, Herba Houttuyniae 5.0-10.0, Bulbus Fritillariae Ussuriensis 5.0-10.0, Semen Armeniacae Amarum 1.0-5.0, Folium Eriobotryae 1.0-5.0, brown sugar 5.0-10.0, sodium benzoate 0.1-1.0, water adds to 100.
2. a kind of Flos nymphaeae (Nymphaea teragona Georgi) antiasthmatic-antitussive syrup according to claim 1 and preparation method thereof, is characterized in that having following preparation technology:
1) Flos nymphaeae (Nymphaea teragona Georgi), Radix Glycyrrhizae, Herba Houttuyniae, Bulbus Fritillariae Ussuriensis, Semen Armeniacae Amarum, Folium Eriobotryae are mixed in proportion, and through grinding, soak one hour;
2), after big fire is heated to boiling, from boiling after 30 minutes, leach head and to boil medicine liquid;
3) add clear water again, continue slow fire and decoct, repeat 2) step 2 ~ 3 time, leach liquid of boiling medicine again;
4) collecting decoction, filters, adds brown sugar in proportion and be condensed into syrup;
5) sodium benzoate powder mix homogeneously is added;
6) sample immediately, after the assay was approved, subpackage, labeling, sealing.
CN201310447839.5A 2013-09-27 2013-09-27 Water lily panting-calming cough-relieving syrup and preparation method thereof Pending CN104510888A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267607A (en) * 2015-11-12 2016-01-27 常州大学 Preparation method of internal and external ointment for treating bronchial asthma

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105267607A (en) * 2015-11-12 2016-01-27 常州大学 Preparation method of internal and external ointment for treating bronchial asthma

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