CN105267607A - Preparation method of internal and external ointment for treating bronchial asthma - Google Patents

Abstract

The invention discloses a preparation method of internal and external ointment for treating bronchial asthma and belongs to the field of preparation of drugs for treating bronchial asthma. The internal and external ointment is made by: washing and sterilizing and grinding Russula vinosa into powder, mixing the powder with water before cooking to obtain filtrate, adding Folium Eriobotryae powder, Radix Glycyrrhizae powder, Herba Houttuyniae powder and Bulbus Fritillariae Cirrhosae, adding water repeatedly for cooking, adding Pericarpium Citri Reticulatae powder and almond powder, dropwise adding sesame oil for cooking, performing soaking in a mixed liquid obtained with Folium Gardeniae and peppermint leaf, and performing concentrating. The preparation method has the advantages that the preparation method is simple, no additive is added during preparing, and a product obtained is natural and nonirritating, is free of side effect, effective to use and suitable for internal and external use and is worthy of popularization and application.

Description

A kind of preparation method for the treatment of bronchial asthma oral administration and externally ointment

Technical field

The present invention relates to a kind of preparation method for the treatment of bronchial asthma oral administration and externally ointment, belong to treatment bronchial asthma medicine preparation field.

Background technology

Asthma is a kind of chronic airway inflammation disease, shows as the symptoms such as the panting of repeated relapsing, tachypnea, uncomfortable in chest, cough, be everlasting night and outbreak aggravation in early morning.Patient's speech utterance is difficult to continuously, and severe patient even can not be talked.Most of patients can be alleviated through treatment, but runs into risk factor, again can recurrent exerbation.Asthma is many because can not effect a radical cure, is slowly transformed into chronic disease, frequently-occurring disease in infant morbidity in period, and this disease also can be lifelong with patient.It is very complicated that it brings out the cause of disease: have environmental pollution, Climate Anomalies, respiratory tract disease, contactant is irritated, food medicine is irritated, the weak immunity of body constitution is low, hereditary etc.

Bronchial asthma is by the various kinds of cell particularly chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte, in susceptible person, this kind of inflammation can cause panting of recurrent exerbation, the symptoms such as tachypnea, uncomfortable in chest and cough, how occurring at night and morning, air flue increases multiple stimulating factor reactivity.But symptom can be alleviated voluntarily or through treatment.In the recent decade, the U.S., Britain, Australia, the national asthma prevalence such as New Zealand and mortality rate on the rise, about there are 100,000,000 asthmatic patients in the whole world, become a kind of major chronic illnesses of serious threat public health, the prevalence of China's asthma is about 1%, child Ke Da 3%, about has more than 1,000 ten thousand asthmatic patients according to the measuring and calculating whole nation.

Asthma pathogenesis is complicated, onset is anxious, rapid onset, often not easily effect a radical cure, there is no the Therapeutic Method of specially good effect at present, the adrenocortical hormone of doctor trained in Western medicine many employings antiinflammatory, coordinate receptor agonist, cholinolytic class medicine, theophylline class medicine etc. to treat, but the long-term taking of this type of medicine can bring the side effect such as hormone dependence, obesity, endocrine regulation to patient.Cause patient to use rear therapeutic effect not obvious, effectively can not treat and control this disease, so that asthma recurrent exerbation, cause patient suffering can't bear.The one-tenth side of Chinese medicine is rarely found, is that doctor outputs magistral prescription according to conditions of patients weight mostly, takes for it temporarily, and curative effect alleviates character, and therapeutic effect is not good, existing defects.Therefore work out the medicine that a kind of curative effect is high, the cycle course for the treatment of is short, not easily recur, have great importance in treatment bronchial asthma.

Summary of the invention

Technical problem to be solved by this invention: hormone can be brought to rely on to patient for the medicine long-term taking for the treatment of bronchial asthma at present, fat, the side effect such as endocrine regulation, and therapeutic effect is not obvious after using, cause patient's asthma recurrent exerbation, the drawback that quality of life reduces, provide a kind of preparation method for the treatment of bronchial asthma oral administration and externally ointment, the present invention is milled into powder after getting Russula cleaning and sterilization, filter to get filtrate with water is steaming mixed, add Loquat Leaf, Radix Glycyrrhizae powder, Heartleaf Houttuynia Herb and Tendrilled Fritillaria Bulb add water after steaming and decocting repeatedly, add tangerine peel powder and Semen Armeniacae Amarum powder, after dripping Oleum sesami steaming and decocting, be immersed in the mixed liquor obtained by Fructus Gardeniae floral leaf and mentha leave and soak, concentrated modulation forms.Preparation method of the present invention is simple, and products obtained therefrom is natural non-stimulated, without any side effects, and result of use is good.

For solving the problems of the technologies described above, the present invention adopts technical scheme as described below to be:

(1) 20 ~ 30g Russula is got, Russula is placed in clear water and soaks 30 ~ 40min, current slightly rinse the mud stain removed on Russula, then carry out air-dry under ventilation state by the Russula after cleaning, uviol lamp is adopted to carry out disinfection sterilization processing 30 ~ 60min, removing harmful substance;

(2) cut into slices with side tool by the Russula after sterilizing, slice thickness is 1 ~ 2cm, after slice completes, is placed in the dry 20 ~ 30min of baking oven of 50 ~ 60 DEG C, puts into pulverizer and pulverize after drying, then puts into mill and be milled into powder;

(3) above-mentioned gained powder is put into vessel, add 70 ~ 90mL water wherein, control temperature is 70 ~ 80 DEG C, after liquid volume in vessel reduces 1/4th, be warming up to 98 ~ 100 DEG C with the speed program of 2 DEG C/min, stop heating, stir until the remaining 20 ~ 25mL of liquid in vessel, be placed in filter while hot to filter, obtain filtrate;

(4) in the filtrate of above-mentioned gained, 5 ~ 6g Loquat Leaf, 3 ~ 5g Radix Glycyrrhizae powder, 4 ~ 6g Heartleaf Houttuynia Herb and 5 ~ 7g Tendrilled Fritillaria Bulb is added respectively, soak 20 ~ 30min, after immersion completes, control temperature is 50 ~ 60 DEG C, stir until mixture be thick after add 20 ~ 25mL water, raised temperature is 90 ~

100 DEG C, boiling to the remaining volume of liquid is 10 ~ 15mL, adds 10 ~ 15mL water wherein, 3 times like this, obtains jelly;

(5) in the jelly of above-mentioned gained, 5 ~ 6g tangerine peel powder and 4 ~ 5g Semen Armeniacae Amarum powder is added respectively, add 20 ~ 30mL water wherein simultaneously, stir 30 ~ 40min, mix homogeneously, then control temperature is 50 ~ 70 DEG C, drips 5 ~ 8mL Oleum sesami wherein while stirring, after dropwising, insulation 10 ~ 15min, obtains dope for subsequent use;

(6) 8 ~ 15g Fructus Gardeniae floral leaf and 5 ~ 6g mentha leave is got, rinse 1 ~ 2 time with clear water, after natural air drying, to carry out disinfection sterilization processing 30 ~ 60min with uviol lamp, removing harmful substance, in 40 ~ 50 DEG C of baking ovens, dry 20 ~ 30min, puts into pulverizer and pulverizes, then puts into mill and be milled into powder;

(7) in above-mentioned powder, water is added, every gram of powder adds 1mL water, soak 2 ~ 3 days at temperature is 40 ~ 50 DEG C, after immersion completes, filter to obtain mixed liquor, dope for subsequent use is put into mixed liquor, flood dope 2 ~ 3cm with mixed liquor to be advisable, keep temperature to be 30 ~ 40 DEG C, soak 5 ~ 7 days, within every two days, change mixed once liquid, form gluey ointment;

(8) prepared gluey ointment is loaded in the circular box after disinfection, envelope box.

Pharmacology analysis of the present invention:

Oleum sesami: the flavoring agent in life.Long this thing of food, delaying sanility, protection blood vessel, loosening bowel to relieve constipation.Meanwhile, it is to respiratory system disease, also has corresponding curative effect.Cough patients, drinks some Oleum sesami before sleeping, and drinks some after within second day, getting up again, and cough just can alleviate.After a couple of days, just can cure.The people smoked, often drinks Oleum sesami, can alleviate cigarette to the direct stimulation of tooth, gingiva, oral mucosa and damage, and the formation of pulmonary's smoking patch.Drink Oleum sesami before drinking, then can play certain protective effect to oral cavity, esophagus, stomach cardia and gastric mucosa.

Bulbus Fritillariae Cirrhosae: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough.

Folium Eriobotryae: clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order is panted, and gastric heat vomiting, dysphoria with smothery sensation is thirsty.Herba Houttuyniae: heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome.For pain in the lung vomiting pus, expectorant dyspnea of heat type is coughed.

Pericarpium Citri Reticulatae: pungent, bitter, temperature, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.

Semen Armeniacae Amarum: expelling phlegm for arresting cough, relievings asthma, intestine moistening.

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat reliving and toxin-eliminating, expelling phlegm for arresting cough, relieving spasm to stop pain.

Flos Gardeniae: clearing away lung-heat to relieve cough, cooling blood for hemostasis.Cure mainly cough due to lung-heat, nose, cough up phlegm, the diseases such as toxic swelling.

Application process of the present invention: oral 5 ~ 7g at every turn, morning and evening every day is each once, after evening is oral, neck clear water is rinsed well, with towel hot compress 10 ~ 20min, obtained ointment is applied in throat, every night once, after 1 ~ 2 day, cough with asthma alleviates, after 3 ~ 4 days, without cough symptom, after 6 ~ 7 days, symptom all disappears.Use rear without any discomfort, short treating period, effect is good, and the state of an illness is without recurrence.

The present invention is compared with additive method, and Advantageous Effects is:

(1) preparation method of the present invention is simple, without any additive in preparation process;

(2) products obtained therefrom is natural non-stimulated, without any side effects, and result of use is good, oral administration external.

Detailed description of the invention

First 20 ~ 30g Russula is got, Russula is placed in clear water and soaks 30 ~ 40min, current slightly rinse the mud stain removed on Russula, then carry out air-dry under ventilation state by the Russula after cleaning, uviol lamp is adopted to carry out disinfection sterilization processing 30 ~ 60min, removing harmful substance; Then cut into slices with side tool by the Russula after sterilizing, slice thickness is 1 ~ 2cm, after slice completes, is placed in the dry 20 ~ 30min of baking oven of 50 ~ 60 DEG C, puts into pulverizer and pulverize after drying, then puts into mill and be milled into powder; Again above-mentioned gained powder is put into vessel, add 70 ~ 90mL water wherein, control temperature is 70 ~ 80 DEG C, after liquid volume in vessel reduces 1/4th, be warming up to 98 ~ 100 DEG C with the speed program of 2 DEG C/min, stop heating, stir until the remaining 20 ~ 25mL of liquid in vessel, be placed in filter while hot to filter, obtain filtrate; 5 ~ 6g Loquat Leaf, 3 ~ 5g Radix Glycyrrhizae powder, 4 ~ 6g Heartleaf Houttuynia Herb and 5 ~ 7g Tendrilled Fritillaria Bulb is added respectively in the filtrate of above-mentioned gained, soak 20 ~ 30min, after immersion completes, control temperature is 50 ~ 60 DEG C, stir until mixture be thick after add 20 ~ 25mL water, raised temperature is 90 ~ 100 DEG C, boil to the remaining volume of liquid be 10 ~ 15mL, add 10 ~ 15mL water wherein, 3 times like this, obtain jelly; 5 ~ 6g tangerine peel powder and 4 ~ 5g Semen Armeniacae Amarum powder is added respectively again in the jelly of above-mentioned gained, add 20 ~ 30mL water wherein simultaneously, stir 30 ~ 40min, mix homogeneously, then control temperature is 50 ~ 70 DEG C, drips 5 ~ 8mL Oleum sesami wherein while stirring, after dropwising, insulation 10 ~ 15min, obtains dope for subsequent use; Get 8 ~ 15g Fructus Gardeniae floral leaf and 5 ~ 6g mentha leave again, rinse 1 ~ 2 time with clear water, after natural air drying, to carry out disinfection sterilization processing 30 ~ 60min with uviol lamp, removing harmful substance, in 40 ~ 50 DEG C of baking ovens, dry 20 ~ 30min, puts into pulverizer and pulverizes, then puts into mill and be milled into powder; Then in above-mentioned powder, water is added, every gram of powder adds 1mL water, soak 2 ~ 3 days at temperature is 40 ~ 50 DEG C, after immersion completes, filter to obtain mixed liquor, dope for subsequent use is put into mixed liquor, flood dope 2 ~ 3cm with mixed liquor to be advisable, keep temperature to be 30 ~ 40 DEG C, soak 5 ~ 7 days, within every two days, change mixed once liquid, form gluey ointment; Finally prepared gluey ointment is loaded in the circular box after disinfection, envelope box.

Example 1

First get 20g Russula, Russula is placed in clear water and soaks 30min, current slightly rinse the mud stain removed on Russula, then carry out air-dry under ventilation state by the Russula after cleaning, adopt uviol lamp to carry out disinfection sterilization processing 30min, removing harmful substance; Then cut into slices with side tool by the Russula after sterilizing, slice thickness is 1cm, after slice completes, is placed in the dry 20min of baking oven of 50 DEG C, puts into pulverizer and pulverize after drying, then puts into mill and be milled into powder; Again above-mentioned gained powder is put into vessel, add 70mL water wherein, control temperature is 70 DEG C, after liquid volume in vessel reduces 1/4th, be warming up to 98 DEG C with the speed program of 2 DEG C/min, stop heating, stir until the remaining 20mL of liquid in vessel, be placed in filter while hot to filter, obtain filtrate; 5g Loquat Leaf, 3g Radix Glycyrrhizae powder, 4g Heartleaf Houttuynia Herb and 5g Tendrilled Fritillaria Bulb is added respectively in the filtrate of above-mentioned gained, soak 20min, after immersion completes, control temperature is 50 DEG C, stir until mixture be thick after add 20mL water, raised temperature is 90 DEG C, boil to the remaining volume of liquid be 10mL, add 10mL water wherein, 3 times like this, obtain jelly; In the jelly of above-mentioned gained, add 5g tangerine peel powder and 4g Semen Armeniacae Amarum powder respectively again, add 20mL water wherein simultaneously, stir 30min, mix homogeneously, then control temperature is 50 DEG C, drips 5mL Oleum sesami wherein while stirring, after dropwising, insulation 10min, obtains dope for subsequent use; Get 8g Fructus Gardeniae floral leaf and 5g mentha leave again, rinse 1 time, after natural air drying with clear water, to carry out disinfection sterilization processing 30min with uviol lamp, removing harmful substance, dry 20min in 40 DEG C of baking ovens, puts into pulverizer and pulverizes, then puts into mill and be milled into powder; Then in above-mentioned powder, water is added, every gram of powder adds 1mL water, soak 2 days at temperature is 40 DEG C, after immersion completes, filter to obtain mixed liquor, dope for subsequent use is put into mixed liquor, flood dope 2cm with mixed liquor to be advisable, keep temperature to be 30 DEG C, soak 5 days, within every two days, change mixed once liquid, form gluey ointment; Finally prepared gluey ointment is loaded in the circular box after disinfection, envelope box.

Each oral 5g, neck clear water respectively once, after evening is oral, is rinsed well, with towel hot compress 10min by every day sooner or later, obtained ointment is applied in throat, and every night once, after 1 day, cough with asthma alleviates, after 3 days, without cough symptom, after 6 days, symptom all disappears.Use rear without any discomfort, short treating period, effect is good, and the state of an illness is without recurrence.

Example 2

First get 25g Russula, Russula is placed in clear water and soaks 35min, current slightly rinse the mud stain removed on Russula, then carry out air-dry under ventilation state by the Russula after cleaning, adopt uviol lamp to carry out disinfection sterilization processing 45min, removing harmful substance; Then cut into slices with side tool by the Russula after sterilizing, slice thickness is 1.5cm, after slice completes, is placed in the dry 25min of baking oven of 55 DEG C, puts into pulverizer and pulverize after drying, then puts into mill and be milled into powder; Again above-mentioned gained powder is put into vessel, add 80mL water wherein, control temperature is 75 DEG C, after liquid volume in vessel reduces 1/4th, be warming up to 99 DEG C with the speed program of 2 DEG C/min, stop heating, stir until the remaining 22mL of liquid in vessel, be placed in filter while hot to filter, obtain filtrate; 5.5g Loquat Leaf, 4g Radix Glycyrrhizae powder, 5g Heartleaf Houttuynia Herb and 6g Tendrilled Fritillaria Bulb is added respectively in the filtrate of above-mentioned gained, soak 25min, after immersion completes, control temperature is 55 DEG C, stir until mixture be thick after add 23mL water, raised temperature is 95 DEG C, boil to the remaining volume of liquid be 13mL, add 13mL water wherein, 3 times like this, obtain jelly; In the jelly of above-mentioned gained, add 5.5g tangerine peel powder and 4.5g Semen Armeniacae Amarum powder respectively again, add 25mL water wherein simultaneously, stir 35min, mix homogeneously, then control temperature is 60 DEG C, drips 7mL Oleum sesami wherein while stirring, after dropwising, insulation 12min, obtains dope for subsequent use; Get 11g Fructus Gardeniae floral leaf and 5.5g mentha leave again, rinse 2 times, after natural air drying with clear water, to carry out disinfection sterilization processing 45min with uviol lamp, removing harmful substance, dry 25min in 45 DEG C of baking ovens, put into pulverizer to pulverize, then put into mill and be milled into powder; Then in above-mentioned powder, water is added, every gram of powder adds 1mL water, soak 3 days at temperature is 45 DEG C, after immersion completes, filter to obtain mixed liquor, dope for subsequent use is put into mixed liquor, flood dope 2.5cm with mixed liquor to be advisable, keep temperature to be 35 DEG C, soak 6 days, within every two days, change mixed once liquid, form gluey ointment; Finally prepared gluey ointment is loaded in the circular box after disinfection, envelope box.

Each oral 6g, neck clear water respectively once, after evening is oral, is rinsed well, with towel hot compress 15min by every day sooner or later, obtained ointment is applied in throat, and every night once, after 2 days, cough with asthma alleviates, after 4 days, without cough symptom, after 6 days, symptom all disappears.Use rear without any discomfort, short treating period, effect is good, and the state of an illness is without recurrence.

Example 3

First get 30g Russula, Russula is placed in clear water and soaks 40min, current slightly rinse the mud stain removed on Russula, then carry out air-dry under ventilation state by the Russula after cleaning, adopt uviol lamp to carry out disinfection sterilization processing 60min, removing harmful substance; Then cut into slices with side tool by the Russula after sterilizing, slice thickness is 2cm, after slice completes, is placed in the dry 30min of baking oven of 60 DEG C, puts into pulverizer and pulverize after drying, then puts into mill and be milled into powder; Again above-mentioned gained powder is put into vessel, add 90mL water wherein, control temperature is 80 DEG C, after liquid volume in vessel reduces 1/4th, be warming up to 100 DEG C with the speed program of 2 DEG C/min, stop heating, stir until the remaining 25mL of liquid in vessel, be placed in filter while hot to filter, obtain filtrate; 6g Loquat Leaf, 5g Radix Glycyrrhizae powder, 6g Heartleaf Houttuynia Herb and 7g Tendrilled Fritillaria Bulb is added respectively in the filtrate of above-mentioned gained, soak 30min, after immersion completes, control temperature is 60 DEG C, stir until mixture be thick after add 25mL water, raised temperature is 100 DEG C, boil to the remaining volume of liquid be 15mL, add 15mL water wherein, 3 times like this, obtain jelly; In the jelly of above-mentioned gained, add 6g tangerine peel powder and 5g Semen Armeniacae Amarum powder respectively again, add 30mL water wherein simultaneously, stir 40min, mix homogeneously, then control temperature is 70 DEG C, drips 8mL Oleum sesami wherein while stirring, after dropwising, insulation 15min, obtains dope for subsequent use; Get 15g Fructus Gardeniae floral leaf and 6g mentha leave again, rinse 2 times, after natural air drying with clear water, to carry out disinfection sterilization processing 60min with uviol lamp, removing harmful substance, dry 30min in 50 DEG C of baking ovens, puts into pulverizer and pulverizes, then puts into mill and be milled into powder; Then in above-mentioned powder, water is added, every gram of powder adds 1mL water, soak 3 days at temperature is 50 DEG C, after immersion completes, filter to obtain mixed liquor, dope for subsequent use is put into mixed liquor, flood dope 3cm with mixed liquor to be advisable, keep temperature to be 40 DEG C, soak 7 days, within every two days, change mixed once liquid, form gluey ointment; Finally prepared gluey ointment is loaded in the circular box after disinfection, envelope box.

Each oral 7g, neck clear water respectively once, after evening is oral, is rinsed well, with towel hot compress 20min by every day sooner or later, obtained ointment is applied in throat, and every night once, after 2 days, cough with asthma alleviates, after 4 days, without cough symptom, after 7 days, symptom all disappears.Use rear without any discomfort, short treating period, effect is good, and the state of an illness is without recurrence.

Claims (1)

1. treat a preparation method for bronchial asthma oral administration and externally ointment, it is characterized in that concrete preparation process is:

(1) 20 ~ 30g Russula is got, Russula is placed in clear water and soaks 30 ~ 40min, current slightly rinse the mud stain removed on Russula, then carry out air-dry under ventilation state by the Russula after cleaning, uviol lamp is adopted to carry out disinfection sterilization processing 30 ~ 60min, removing harmful substance;

(2) cut into slices with side tool by the Russula after sterilizing, slice thickness is 1 ~ 2cm, after slice completes, is placed in the dry 20 ~ 30min of baking oven of 50 ~ 60 DEG C, puts into pulverizer and pulverize after drying, then puts into mill and be milled into powder;

(3) above-mentioned gained powder is put into vessel, add 70 ~ 90mL water wherein, control temperature is 70 ~ 80 DEG C, after liquid volume in vessel reduces 1/4th, be warming up to 98 ~ 100 DEG C with the speed program of 2 DEG C/min, stop heating, stir until the remaining 20 ~ 25mL of liquid in vessel, be placed in filter while hot to filter, obtain filtrate;

(4) in the filtrate of above-mentioned gained, 5 ~ 6g Loquat Leaf, 3 ~ 5g Radix Glycyrrhizae powder, 4 ~ 6g Heartleaf Houttuynia Herb and 5 ~ 7g Tendrilled Fritillaria Bulb is added respectively, soak 20 ~ 30min, after immersion completes, control temperature is 50 ~ 60 DEG C, stir until mixture be thick after add 20 ~ 25mL water, raised temperature is 90 ~ 100 DEG C, boil to the remaining volume of liquid be 10 ~ 15mL, add 10 ~ 15mL water wherein, 3 times like this, obtain jelly;

(5) in the jelly of above-mentioned gained, 5 ~ 6g tangerine peel powder and 4 ~ 5g Semen Armeniacae Amarum powder is added respectively, add 20 ~ 30mL water wherein simultaneously, stir 30 ~ 40min, mix homogeneously, then control temperature is 50 ~ 70 DEG C, drips 5 ~ 8mL Oleum sesami wherein while stirring, after dropwising, insulation 10 ~ 15min, obtains dope for subsequent use;

(6) 8 ~ 15g Fructus Gardeniae floral leaf and 5 ~ 6g mentha leave is got, rinse 1 ~ 2 time with clear water, after natural air drying, to carry out disinfection sterilization processing 30 ~ 60min with uviol lamp, removing harmful substance, in 40 ~ 50 DEG C of baking ovens, dry 20 ~ 30min, puts into pulverizer and pulverizes, then puts into mill and be milled into powder;

(7) in above-mentioned powder, water is added, every gram of powder adds 1mL water, soak 2 ~ 3 days at temperature is 40 ~ 50 DEG C, after immersion completes, filter to obtain mixed liquor, dope for subsequent use is put into mixed liquor, flood dope 2 ~ 3cm with mixed liquor to be advisable, keep temperature to be 30 ~ 40 DEG C, soak 5 ~ 7 days, within every two days, change mixed once liquid, form gluey ointment;

(8) prepared gluey ointment is loaded in the circular box after disinfection, envelope box.