CN104507912B - (氮杂-)异喹啉酮衍生物 - Google Patents

(氮杂-)异喹啉酮衍生物 Download PDF

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Publication number
CN104507912B
CN104507912B CN201380041848.2A CN201380041848A CN104507912B CN 104507912 B CN104507912 B CN 104507912B CN 201380041848 A CN201380041848 A CN 201380041848A CN 104507912 B CN104507912 B CN 104507912B
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Prior art keywords
phenyl
methyl
ethyl
compounds
mmol
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Expired - Fee Related
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CN201380041848.2A
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English (en)
Chinese (zh)
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CN104507912A (zh
Inventor
D.多施
H-P.布希施塔勒
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380041848.2A 2012-08-08 2013-07-12 (氮杂-)异喹啉酮衍生物 Expired - Fee Related CN104507912B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12005752 2012-08-08
EP12005752.6 2012-08-08
PCT/EP2013/002085 WO2014023390A2 (en) 2012-08-08 2013-07-12 (aza-)isoquinolinone derivatives

Publications (2)

Publication Number Publication Date
CN104507912A CN104507912A (zh) 2015-04-08
CN104507912B true CN104507912B (zh) 2016-09-28

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CN201380041848.2A Expired - Fee Related CN104507912B (zh) 2012-08-08 2013-07-12 (氮杂-)异喹啉酮衍生物

Country Status (23)

Country Link
US (1) US9376433B2 (https=)
EP (1) EP2882714B1 (https=)
JP (2) JP6247294B2 (https=)
KR (1) KR102083154B1 (https=)
CN (1) CN104507912B (https=)
AR (1) AR092366A1 (https=)
AU (1) AU2013301870B2 (https=)
BR (1) BR112015002601A2 (https=)
CA (1) CA2881330C (https=)
DK (1) DK2882714T3 (https=)
ES (1) ES2773272T3 (https=)
HR (1) HRP20200180T1 (https=)
HU (1) HUE047608T2 (https=)
IL (1) IL237072B (https=)
LT (1) LT2882714T (https=)
MX (1) MX362939B (https=)
PL (1) PL2882714T3 (https=)
PT (1) PT2882714T (https=)
RS (1) RS59921B1 (https=)
RU (1) RU2654216C2 (https=)
SG (1) SG11201500732TA (https=)
SI (1) SI2882714T1 (https=)
WO (1) WO2014023390A2 (https=)

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JP2942847B2 (ja) 1990-06-22 1999-08-30 ダイセル化学工業株式会社 液晶性ポリマーフィルムの製造装置とそれを用いた液晶性ポリマーフィルムの製造方法
WO2013132253A1 (en) 2012-03-07 2013-09-12 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
WO2014087165A1 (en) * 2012-12-06 2014-06-12 University Of Bath Tankyrase inhibitors
EP3044221B1 (en) 2013-09-11 2018-02-21 Institute of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
UY36060A (es) 2014-04-02 2015-10-30 Bayer Pharma AG Compuestos de azol sustituidos con amida
RU2672722C2 (ru) * 2014-04-10 2018-11-19 Хубэй Био-Фармасьютикал Индастриал Текнолоджикал Инститьют Инк. Аналоги соединений 4н-пиразоло[1,5-а]бензимидазола в качестве ингибиторов parp
CN105153156B (zh) * 2015-09-22 2017-07-28 徐峰 一种4‑苯基‑2,7‑萘啶‑1（2h）‑酮的制备方法
WO2017055316A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
WO2017055313A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
US10759795B2 (en) 2016-03-15 2020-09-01 Purdue Research Foundation Aza-A-ring indenoisoquinoline topoisomerase I poisons
WO2018078005A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted azaspiro derivatives as tankyrase inhibitors
WO2018078009A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives
WO2018087126A1 (en) 2016-11-09 2018-05-17 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives as inhibitors of tankyrase
CN110167936A (zh) 2016-12-22 2019-08-23 珀杜研究基金会 氮杂茚并异喹啉化合物及其用途
US10899733B2 (en) 2017-08-23 2021-01-26 Oregon Health & Science University Inhibitors of PARPs that catalyze mono-ADP-ribosylation
RU2709928C1 (ru) * 2019-02-21 2019-12-24 Федеральное государственное бюджетное научное учреждение "Институт природно-технических систем" (ИПТС) Датчик удельной электропроводности
WO2024029583A1 (ja) * 2022-08-05 2024-02-08 国立研究開発法人理化学研究所 新規ピラゾール誘導体及びその用途
GB2634228A (en) * 2023-10-02 2025-04-09 Duke Street Bio Ltd PARP1 inhibitor compounds

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Publication number Publication date
LT2882714T (lt) 2020-03-10
WO2014023390A2 (en) 2014-02-13
IL237072B (en) 2018-11-29
JP2018008974A (ja) 2018-01-18
JP2015524450A (ja) 2015-08-24
JP6247294B2 (ja) 2017-12-13
EP2882714A2 (en) 2015-06-17
KR20150041649A (ko) 2015-04-16
AR092366A1 (es) 2015-04-15
DK2882714T3 (da) 2020-01-20
PL2882714T3 (pl) 2020-02-28
AU2013301870A1 (en) 2015-03-19
RS59921B1 (sr) 2020-03-31
HK1209106A1 (en) 2016-03-24
US20150210686A1 (en) 2015-07-30
RU2654216C2 (ru) 2018-05-17
US9376433B2 (en) 2016-06-28
CA2881330A1 (en) 2014-02-13
MX2015001545A (es) 2015-05-11
HUE047608T2 (hu) 2020-05-28
JP6333450B2 (ja) 2018-05-30
CA2881330C (en) 2020-07-21
HRP20200180T1 (hr) 2020-05-01
WO2014023390A3 (en) 2014-04-10
SG11201500732TA (en) 2015-02-27
MX362939B (es) 2019-02-27
PT2882714T (pt) 2020-02-19
ES2773272T3 (es) 2020-07-10
KR102083154B1 (ko) 2020-03-02
CN104507912A (zh) 2015-04-08
SI2882714T1 (sl) 2020-03-31
EP2882714B1 (en) 2019-11-13
RU2015107702A (ru) 2016-09-27
BR112015002601A2 (pt) 2017-07-04
AU2013301870B2 (en) 2017-04-27

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