CN104491532A - Traditional Chinese medicine for treating stomach heat and application thereof - Google Patents

Traditional Chinese medicine for treating stomach heat and application thereof Download PDF

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CN104491532A
CN104491532A CN201410774247.9A CN201410774247A CN104491532A CN 104491532 A CN104491532 A CN 104491532A CN 201410774247 A CN201410774247 A CN 201410774247A CN 104491532 A CN104491532 A CN 104491532A
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chinese medicine
parts
traditional chinese
herba
rhizoma
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崔合芳
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/614—Cnidaria, e.g. sea anemones, corals, coral animals or jellyfish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)

Abstract

The invention discloses a traditional Chinese medicine for treating stomach heat and application thereof and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine is prepared from the following fourteen traditional Chinese medicines of rhizoma phragmitis, coptis chinensis, agastache rugosus, rheum officinale, cavernularia habereri, rhizoma anemarrhenae, radices trichosanthis, securidaca inapfondiculata, semen raphani, franxinus pistacifolia feng, oenanthe rivularis, polyalthia root, caesalpinia and small madder. The traditional Chinese medicine has good treatment effects of treating fever, headache, thirst, dry throat and sore throat, dysphoria, cough, abdominal distension constipation, yellow urine, reddened tongue with yellow fur, facial flushing and the like caused by stomach heat; the preparation method of the traditional Chinese medicine is simple, stable in preparation and liable to popularize and apply.

Description

A kind of Chinese medicine and application thereof for the treatment of gastric heat
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine and application thereof for the treatment of gastric heat.
Technical background
Along with the fast development of society, the rhythm of life of people accelerates, many people are not careful in one's diet, breakfast skipping, after meal strenuous exercise, have enough and namely sleep, eat support or the phenomenon such as to like hot and spicy food is general, chronic dietary is irregular directly causes gastropathy, gastric heat phenomenon is the early symptom of stomach discomfort, as treated not in time, will develop into the serious gastropathy such as gastritis, gastric ulcer.
The traditional Chinese medical science thinks that gastric heat is that stomach has been subject to pathogenic heat, or excessive edible decocting fries scorching food, occurs the symptoms such as thirsty, bitter taste, halitosis, xerostomia, oral erosion, gingival swelling and pain, dry pharynx, oliguria with reddish urine, constipation; Gastric heat patient likes eating ice-cold food usually, does not like the food eating heat, usually after the ice-cold food of a large amount of diet, has comfort; During gastric heat pain, how with the rough random thoughts of gastric.Part gastric heat patient can feel flatulence, not have appetite, and some gastric heat patient then due to stomach overacfivity, quickening of wriggling, shows as and has a very good appetite, constantly take food.
Cause the reason of gastric heat to have a lot, be addicted to drink, all may cause gastric heat addicted to improper diet problems such as pungent, the excessive edible rich foods of food; And the stagnation of QI, blood stasis, expectorant, wet, food stagnation etc. also can pent-up heat-transformation, fire-transformation, cause gastric heat (stomach-fire); In addition, incoordination between the liver and stomach, also can cause gastric heat.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of good effect, instant effect, safely, the Chinese medicine for the treatment of gastric heat that has no side effect.
In order to solve the problem, inventor's foundation tcm clinical practice experience for many years and the ill feature of modern, provide a kind of Chinese medicine for the treatment of gastric heat, be made up of the crude drug of following weight portion:
Rhizoma Phragmitis 20-25 part, Rhizoma Coptidis 20-25 part, Herba Pogostemonis 20-25 part, extra large Radix et Caulis Opuntiae Dillenii 20-25 part, Radix Et Rhizoma Rhei 10-15 part, Rhizoma Anemarrhenae 10-15 part, Radix Trichosanthis 12-15 part, five tastes rattan 12-15 part, Semen Raphani 12-15 part, great Pi disappear 15-18 part, Mengzi Herba Oenanthes Javanicae 15-18 part, Polyalthia nemoralis A. D C. 15-18 part, Herba Bulbophylli reptantis 18-23 part, Herba Rubiae Yunnanensis 18-23 part.
Preferably, a kind of Chinese medicine for the treatment of gastric heat, is made up of the crude drug of following weight portion:
Rhizoma Phragmitis 23 parts, Rhizoma Coptidis 23 parts, Herba Pogostemonis 22 parts, extra large Radix et Caulis Opuntiae Dillenii 23 parts, Radix Et Rhizoma Rhei 12 parts, the Rhizoma Anemarrhenae 12 parts, Radix Trichosanthis 14 parts, 14 parts, five tastes rattan, Semen Raphani 13 parts, great Pi disappear 16 parts, Mengzi Herba Oenanthes Javanicae 16 parts, Polyalthia nemoralis A. D C. 16 parts, Herba Bulbophylli reptantis 20 parts, Herba Rubiae Yunnanensis 20 parts.
For adapting to the Medicinal Trait of modern, be convenient for carrying and take, the feature of inventor according to modern pharmaceutical technology and the extracting mode of Effective Component of Chinese Medicine, meticulously have developed a set of preparation method, this prescription can be made finished product preparation, the method is simple to operate, is easy to apply, and it is following steps:
Step 1, accurately to take by Chinese prescription of the present invention: Rhizoma Phragmitis, Rhizoma Coptidis, Herba Pogostemonis, Radix Et Rhizoma Rhei, extra large Radix et Caulis Opuntiae Dillenii, the Rhizoma Anemarrhenae, Radix Trichosanthis, five tastes rattan, Semen Raphani, great Pi disappear, Mengzi Herba Oenanthes Javanicae, Polyalthia nemoralis A. D C., Herba Bulbophylli reptantis, Herba Rubiae Yunnanensis, pulverize respectively, mix;
Step 2, add the purified water of 8 times of weight, backflow decocts 1.5-2.5 hour, and filter to get filtrate a; In filtering residue, add the purified water of 3 times of initial medical material weight, backflow decocts 1-2 hour, and filter to get filtrate b; In filtering residue, add the purified water of 2 times of initial medical material weight, backflow decoction 1 hour, filter to get filtrate c; By filtrate a, b, c mix, carry out concentrating under reduced pressure, until the relative density of mixed liquor is 1.17-1.25(70-75 DEG C of surveys) time stop concentrate, be the concentrated liquid of tradition Chinese medicine;
Step 3, the concentrated liquid of tradition Chinese medicine is added adjuvant make the Chinese medicine finished product preparation such as pill, granule or oral liquid.
Preferably, Chinese medicine preparation of the present invention is granule.
The source of the present invention's Chinese crude drug used, feature, meridian distribution of property and flavor and effect:
Rhizoma Phragmitis: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For calentura excessive thirst, gastric heat is vomitted the sound of vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; Select the dry rhizome of cohosh Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao and Coptis Teeta Wall.
Herba Pogostemonis: dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.Main summertime flu; Cold and heat are had a headache; Breast gastral cavity painful abdominal mass is vexed; Vomiting is had loose bowels; Vomiting during pregnancy; Nasal sinusitis; Hands; Tinea pedis.Select the aerial parts of labiate Herba Pogostemonis.
Radix Et Rhizoma Rhei: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Select the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.
Sea Radix et Caulis Opuntiae Dillenii: sweet in the mouth; Salty; Property is put down; Pathogenic fire reducing, removing toxic substances, eliminating stagnation, preventing phlegm from forming and stopping coughing.Main parotitis, bronchitis.Select the entirety of extra large celestial being normal section animal sea Radix et Caulis Opuntiae Dillenii.
The Rhizoma Anemarrhenae: clearing away heat-fire, promotes the production of body fluid and moisturizes.Cure mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.Select the dry rhizome of the monocotyledon Liliaceae Rhizoma Anemarrhenae.
Radix Trichosanthis: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.Select cucurbitaceous plant Fructus Trichosanthis. or the dry root of trichosanthes rosthornii Harms.
Five tastes rattan: expelling wind and removing dampness; Eliminating stasis to stop pain.Main traumatic injury; Rheumatic ostalgia; Acute gastroenteritis; Allergic dermatitis.Select the root of milk wort Radix securidacae.
Semen Raphani: pungent, sweet, flat.Return lung, spleen, stomach warp.Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Great Pi disappears: invigorating the stomach and promoting digestion, circulation of qi promoting treating blood disorders.Cure mainly food stagnation stomachache, chronic gastritis, qi-stagnating amenorrhea, migraine.Red River is regional with controlling tertian malaria, subtertian malaria; Root is used for driving pinworm.Select sweet-scented osmanthus University of Science and Technology skin to disappear to be used as medicine with bark.
Mengzi Herba Oenanthes Javanicae: stomach invigorating removing food stagnancy; Clearing away heat and promoting diuresis; Subduing swelling and detoxicating.Main chronic gastritis; Food stagnation is had a stomachache; Nebulousurine; Drench pain; Treating swelling and pain by traumatic injury; Blood deficiency pathogenic wind toxic.Select the herb of samphire Mengzi Herba Oenanthes Javanicae.
Polyalthia nemoralis A. D C.: spleen reinforcing stomach invigorating, tonifying the kidney to consolidate the essence.Cure mainly chronic gastritis, inappetence, myasthenia of limbs, seminal emission.Select annonaceae Polyalthia nemoralis A. D C., be used as medicine with root.
Herba Bulbophylli reptantis: nourishing the lung to arrest cough; Nourishing the stomach to promote the production of body fluid; Reunion of fractured tendons and bones.Main cough spitting of blood; Chronic pharyngalgia; Chronic gastritis; Traumatic injury; Fracture.Orchid is selected to lie prostrate the herb of raw Bulbophyllum.
Herba Rubiae Yunnanensis: enrich blood and invigorate blood circulation; Expelling wind and removing dampness.Main anemia; Dizzy insomnia; Rheumatic arthralgia; Chronic gastritis; Traumatic injury; Menoxenia.Maguireothamnus speciosus Yunnan is selected to wish the aerial parts of grass.
The prescription analysis of Chinese medicine of the present invention:
Chinese medicine of the present invention is that clearing away heat-fire, promotes the production of body fluid and moisturize, removing dampness to restore normal function of the stomach with Rhizoma Phragmitis, Rhizoma Coptidis, Herba Pogostemonis, Radix Et Rhizoma Rhei, extra large Radix et Caulis Opuntiae Dillenii, the Rhizoma Anemarrhenae, Radix Trichosanthis, Semen Raphani, Mengzi Herba Oenanthes Javanicae for monarch drug; Disappear with five tastes rattan, great Pi, Polyalthia nemoralis A. D C., Herba Bulbophylli reptantis, Herba Rubiae Yunnanensis for ministerial drug, enrich blood and invigorate blood circulation, invigorating the stomach and promoting digestion, circulation of qi promoting treating blood disorders; The all medicines of the monarch and his subjects coordinate, and mutually coordinate, combined effect, reach dispelling wind and heat pathogens, clearing interior heat, heat-clearing and toxic substances removing, the effect of relieving sore throat and pain, the symptom such as heating, headache, thirsty, dry pharynx pain, agitation, cough, abdominal distention constipation, yellowish urine, red tongue with yellow fur, flush that treatment gastric heat causes.
Compared with prior art, Chinese medicine of the present invention has treating both the principal and secondary aspects of a disease, regulates and treats the technical advantage of laying equal stress on, and evident in efficacy, general strong adaptability, preparation technology is easy, is easy to apply.
Detailed description of the invention
Embodiment 1
1) accurately take by Chinese prescription of the present invention: Rhizoma Phragmitis 2000g, Rhizoma Coptidis 2000g, Herba Pogostemonis 2000g, extra large Radix et Caulis Opuntiae Dillenii 2000g, Radix Et Rhizoma Rhei 1000g, Rhizoma Anemarrhenae 1000g, Radix Trichosanthis 1200g, five tastes rattan 1200g, Semen Raphani 1200g, great Pi disappear 1500g, Mengzi Herba Oenanthes Javanicae 1500g, Polyalthia nemoralis A. D C. 1500g, Herba Bulbophylli reptantis 1800g, Herba Rubiae Yunnanensis 1800g, pulverize respectively, mixing;
2) add the purified water of 8 times of weight, backflow decoction 2 hours, filter to get filtrate a; In filtering residue, add the purified water of the initial medical material weight of initial medical material 3 times, backflow decoction 1.5 hours, filter to get filtrate b; In filtering residue, add the purified water of the initial medical material weight of initial medical material 2 times, backflow decoction 1 hour, filter to get filtrate c; By filtrate a, b, c mix, carry out concentrating under reduced pressure, until the relative density of mixed liquor is 1.20(73 DEG C of surveys) time stop concentrate, be the concentrated liquid of tradition Chinese medicine;
3) the concentrated liquid of tradition Chinese medicine is added adjuvant and make granule, amount to crude drug content and be about 0.24g crude drug/g granule.
Embodiment 2
1) accurately take by Chinese prescription of the present invention: Rhizoma Phragmitis 2500g, Rhizoma Coptidis 2500g, Herba Pogostemonis 2500g, extra large Radix et Caulis Opuntiae Dillenii 2500g, Radix Et Rhizoma Rhei 1500g, Rhizoma Anemarrhenae 1500g, Radix Trichosanthis 1500g, five tastes rattan 1500g, Semen Raphani 1500g, great Pi disappear 1800g, Mengzi Herba Oenanthes Javanicae 1800g, Polyalthia nemoralis A. D C. 1800g, Herba Bulbophylli reptantis 2300g, Herba Rubiae Yunnanensis 2300g, pulverize respectively, mixing;
2) add the purified water of 8 times of weight, backflow decoction 2 hours, filter to get filtrate a; In filtering residue, add the purified water of the initial medical material weight of initial medical material 3 times, backflow decoction 1.5 hours, filter to get filtrate b; In filtering residue, add the purified water of the initial medical material weight of initial medical material 2 times, backflow decoction 1 hour, filter to get filtrate c; By filtrate a, b, c mix, carry out concentrating under reduced pressure, until the relative density of mixed liquor is 1.20(73 DEG C of surveys) time stop concentrate, be the concentrated liquid of tradition Chinese medicine;
3) the concentrated liquid of tradition Chinese medicine is added adjuvant and make granule, amount to crude drug content and be about 0.24g crude drug/g granule.
Embodiment 3
1) accurately take by Chinese prescription of the present invention: Rhizoma Phragmitis 2300g, Rhizoma Coptidis 2300g, Herba Pogostemonis 2200g, extra large Radix et Caulis Opuntiae Dillenii 2300g, Radix Et Rhizoma Rhei 1200g, Rhizoma Anemarrhenae 1200g, Radix Trichosanthis 1400g, five tastes rattan 1400g, Semen Raphani 1300g, great Pi disappear 1600g, Mengzi Herba Oenanthes Javanicae 1600g, Polyalthia nemoralis A. D C. 1600g, Herba Bulbophylli reptantis 2000g, Herba Rubiae Yunnanensis 2000g, pulverize respectively, mixing;
2) add the purified water of 8 times of weight, backflow decoction 2 hours, filter to get filtrate a; In filtering residue, add the purified water of the initial medical material weight of initial medical material 3 times, backflow decoction 1.5 hours, filter to get filtrate b; In filtering residue, add the purified water of the initial medical material weight of initial medical material 2 times, backflow decoction 1 hour, filter to get filtrate c; By filtrate a, b, c mix, carry out concentrating under reduced pressure, until the relative density of mixed liquor is 1.20(73 DEG C of surveys) time stop concentrate, be the concentrated liquid of tradition Chinese medicine;
3) the concentrated liquid of tradition Chinese medicine is added adjuvant and make granule, amount to crude drug content and be about 0.24g crude drug/g granule.
Embodiment 4
1) accurately take by Chinese prescription of the present invention: Rhizoma Phragmitis 2300g, Rhizoma Coptidis 2300g, Herba Pogostemonis 2000g, extra large Radix et Caulis Opuntiae Dillenii 2000g, Radix Et Rhizoma Rhei 1200g, Rhizoma Anemarrhenae 1500g, Radix Trichosanthis 1200g, five tastes rattan 1500g, Semen Raphani 1200g, great Pi disappear 1500g, Mengzi Herba Oenanthes Javanicae 1800g, Polyalthia nemoralis A. D C. 1800g, Herba Bulbophylli reptantis 1800g, Herba Rubiae Yunnanensis 2200g, pulverize respectively, mixing;
2) add the purified water of 8 times of weight, backflow decoction 2 hours, filter to get filtrate a; In filtering residue, add the purified water of the initial medical material weight of initial medical material 3 times, backflow decoction 1.5 hours, filter to get filtrate b; In filtering residue, add the purified water of the initial medical material weight of initial medical material 2 times, backflow decoction 1 hour, filter to get filtrate c; By filtrate a, b, c mix, carry out concentrating under reduced pressure, until the relative density of mixed liquor is 1.20(73 DEG C of surveys) time stop concentrate, be the concentrated liquid of tradition Chinese medicine;
3) the concentrated liquid of tradition Chinese medicine is added adjuvant and make granule, amount to crude drug content and be about 0.24g crude drug/g granule.
The animal toxicity test of embodiment 5 Chinese medicine granules of the present invention
(1) test drug: Chinese medicine granules obtained by embodiment of the present invention 1-4, is modulated into solution by purified water by 1 ﹕ 1.Test animal used: regular grade NIH mice, body weight 21g ± 5g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 215g ± 7g, male and female half and half, female rats is all without pregnant.
(2) acute toxicity test
Application mice carries out acute toxicity testing and shows: the By Chinese Medicines that mouse stomach modulates, under 759.6g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach Chinese medicine granules of the present invention is 759.6g crude drug/kg/d(LD 50> 759.6g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.12g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 6330 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
(3) long term toxicity test
Select SD rat, give the Chinese medicine granules of the present invention of Three doses: 21.6g crude drug/kg, 7.2g crude drug/kg, 2.4g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to Pharmacopoeia of the People's Republic of China version in 2010).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.
Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (21.6g crude drug/kg, 7.2g crude drug/kg, 2.4g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.
Embodiment 6, clinical effectiveness are tested
1, experimenter's data
Experimenter all carrys out the gastric heat patient that self-institute in December, 2011 to 2014 is accepted for medical treatment year February, therefrom selects patient 124 example being applicable to test, wherein man 52 example, age 17-69 year, female 72 example, age 16-72 year.According to ill weight, age, sex, experimenter is divided into 4 groups, is numbered matched group, real 1 group, real 2 groups, in fact 3 groups respectively.Often organize 31 people, male 13 people, female 18 people.
2, test method
(1) matched group takes Rhizoma Coptidis clearing stomach ball (Harbin Tongyitang Pharmaceutical Co., Ltd., the accurate word Z23022198 of traditional Chinese medicines), every day 2 times, each 10g.
(2) real 1 group, real 2 groups, real 3 groups of Chinese medicinal granules taken respectively obtained by embodiment of the present invention 1-3, every day 2 times, it is 3.6g that each 15g(amounts to crude drug).
Within (3) 1 weeks, be a course for the treatment of, treat 3 courses for the treatment of continuously.In therapeutic process, cured person can depart from treatment at any time, simultaneously the situation such as health, untoward reaction of record patient.After six months return visit is followed the tracks of to healing person, record recidivist.
(4) quit smoking during patient consumes, wine and pungent, greasy food.
3, evaluation criterion
(1) cure: the gastric heat symptom such as heating, headache, thirsty, dry pharynx pain, agitation, cough, abdominal distention constipation, yellowish urine, red tongue with yellow fur, flush disappears completely.
(2) effective: the gastric heat symptom partial disappearance such as heating, headache, thirsty, dry pharynx pain, agitation, cough, abdominal distention constipation, yellowish urine, red tongue with yellow fur, flush or alleviate to some extent, need continual cure.
(3) invalid: the gastric heat symptom such as heating, headache, thirsty, dry pharynx pain, agitation, cough, abdominal distention constipation, yellowish urine, red tongue with yellow fur, flush is without any improvement, even more serious.
(4) untoward reaction.
(5) recur.
4, result of the test
After test all terminates, statistical analysis is carried out, in table 1, table 2 to test data sheet data.
Table 1 result of the test statistical analysis table
Table 2 is cured case and is cured used time statistical table
5, conclusion (of pressure testing)
As can be seen from the result of the test of two aspects, the average cure rate (68.8%) of Chinese medicine of the present invention to gastric heat patient is 1.8 times of contrast medicine, average total effective rate (94.6%) is higher by 23.6% than contrast medicine, and matched group has 3 routine untoward reaction, and 3 experimental grouies all have no adverse reaction; In addition, in the case that experimental group is cured, about 65% healing time is in 1-2 course for the treatment of, and matched group then concentrated on for the 3rd course for the treatment of.Therefore, as can be seen from these data, the Chinese medicine of the present invention preparation that particularly prepared by embodiment 3 has good effect, it is fast to cure, efficacy stability, the technical advantage that not easily recurs, obtains beat all technological achievement.

Claims (5)

1. treat a Chinese medicine for gastric heat, it is characterized in that being obtained by the raw material of following weight portion: Rhizoma Phragmitis 20-25 part, Rhizoma Coptidis 20-25 part, Herba Pogostemonis 20-25 part, extra large Radix et Caulis Opuntiae Dillenii 20-25 part, Radix Et Rhizoma Rhei 10-15 part, Rhizoma Anemarrhenae 10-15 part, Radix Trichosanthis 12-15 part, five tastes rattan 12-15 part, Semen Raphani 12-15 part, great Pi disappear 15-18 part, Mengzi Herba Oenanthes Javanicae 15-18 part, Polyalthia nemoralis A. D C. 15-18 part, Herba Bulbophylli reptantis 18-23 part, Herba Rubiae Yunnanensis 18-23 part.
2. treat the Chinese medicine of gastric heat according to claim 1, it is characterized in that being obtained by the raw material of following weight portion: Rhizoma Phragmitis 23 parts, Rhizoma Coptidis 23 parts, Herba Pogostemonis 22 parts, extra large Radix et Caulis Opuntiae Dillenii 23 parts, Radix Et Rhizoma Rhei 12 parts, the Rhizoma Anemarrhenae 12 parts, Radix Trichosanthis 14 parts, 14 parts, five tastes rattan, Semen Raphani 13 parts, great Pi disappear 16 parts, Mengzi Herba Oenanthes Javanicae 16 parts, Polyalthia nemoralis A. D C. 16 parts, Herba Bulbophylli reptantis 20 parts, Herba Rubiae Yunnanensis 20 parts.
3. according to claim 1 or 2, treat the Chinese medicine of gastric heat, it is characterized in that: described Chinese medicine can make pill, granule or oral liquid.
4. treat the Chinese medicine of gastric heat according to claim 3, it is characterized in that: described Chinese medicine is granule.
5. described in claim 1 or 2, treat the application of Chinese medicine in preparation treatment gastric heat medicine of gastric heat.
CN201410774247.9A 2014-12-16 2014-12-16 Traditional Chinese medicine for treating stomach heat and application thereof Withdrawn CN104491532A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103830424A (en) * 2014-03-12 2014-06-04 张勇 Traditional Chinese medicine for treating aphtha caused by excessive heat of spleen and stomach and fumigation of latent fire and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103830424A (en) * 2014-03-12 2014-06-04 张勇 Traditional Chinese medicine for treating aphtha caused by excessive heat of spleen and stomach and fumigation of latent fire and preparation method thereof

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Application publication date: 20150408