CN104491348A - Antipyretic and antitoxic drug for febrile convulsion and preparation method of drug - Google Patents

Antipyretic and antitoxic drug for febrile convulsion and preparation method of drug Download PDF

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CN104491348A
CN104491348A CN201410783168.4A CN201410783168A CN104491348A CN 104491348 A CN104491348 A CN 104491348A CN 201410783168 A CN201410783168 A CN 201410783168A CN 104491348 A CN104491348 A CN 104491348A
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fructus forsythiae
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郝贵华
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Abstract

The invention discloses an antipyretic and antitoxic drug for febrile convulsion and a preparation method of the drug. The antipyretic and antitoxic drug is prepared from the following main raw material medicines in parts by weight: 12-25 parts of forsythia, 6-10 parts of polygala japonica, 4-8 parts of coptis, 6-9 parts of tylophora florlbunda, 10-20 parts of jasmine, 5-10 parts of peristrophe, 7-12 parts of uncaria, 8-15 parts of lactuca indica, 3-5 parts of amber, 9-12 parts of rhizoma anemarrhenae, 2-6 parts of calculus bovis and 5-10 parts of coralhead plant stem with leaf. The antipyretic and antitoxic drug quick becomes effective, and is short in treatment period, safe, free of toxic side effect, capable of treating both symptoms and root causes and is unlikely to recur.

Description

Infantile convulsion eliminating pestilence and relieving toxicity medicament and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of infantile convulsion eliminating pestilence and relieving toxicity medicament and preparation method thereof.
Background technology
Infantile convulsion is the common anxious severe disease card of one in children's period, clinically to have a convulsion, to go into a coma as principal character.Also known as " convulsions ", popular name " convulsion ".Show as paroxysmal extremity and facial muscle twitch, how to turn over on the eyeball of both sides, stare or to look side ways, obnubilation.Sometimes with to spit out white foams or the corners of the mouth affects, asphyxia, purplish complexion, duration of seizure is many within 3 ~ 5 minutes, recurrent exerbation sometimes, even in persistent state.The common emergency case of children's, especially common with infant.The incidence rate of fainting from fear the childhood period of less than 6 years old is about 4% ~ 6%, and be comparatively grown up high 10 ~ 15 times, the age, less incidence rate was higher.The frequent outbreak of fainting from fear or persistent state can jeopardize infant life maybe can make infant leave over serious sequela, affects intelligent development and the health of children's.In the doctor trained in Western medicine etiological classification of infantile convulsion and feature: 1, venereal infection is because of (1) intracranial infection: as by antibacterial, virus, parasite, fungus-caused meningitis or encephalitis.Often show as serious convulsive attack repeatedly, mostly appear at disease initial stage or crisis.With the performance of disturbance of consciousness in various degree and increased intracranial pressure.Examination of cerebrospinal fluid has larger help to diagnosis and differential diagnosis.(2) cranium infects outward: the convulsive attack that non-intracranial infection causes.1) febrile convulsion: be the modal acute convulsions of department of pediatrics.2) infect toxic encephalopthy: mostly concurrent in the sexy infectious diseases of the serious bacterial such as septicemia, severe pneumonia, bacillary dysentery, pertussis, cause acute cerebral edema relevant with infection and bacteriotoxin.2, the non-infectious cause of disease (1) intracranial disease: 1) craniocerebral injury and hemorrhage: the intracranial hemorrhage caused as a variety of causes such as maternal infuries, craniocerebral trauma and cerebrovascular malformations.Onset immediately after wound, repeatedly faint from fear companion's disturbance of consciousness and increased intracranial pressure, cerebral CT has important value to diagnosis.2) congenital development deformity: as cranium encephalodysplasia, hydrocephalus, neurocutaneous syndrome etc.3) intracranial spaceoccupying lesion: as on curtain, Interhemispheric tumor, cyst or hematoma etc.(2) outer (general) disease of cranium: 1) hypoxia ischemic injury: as childbirth or anoxia after birth, drowned, cardiopulmonary serious disease etc.2) metabolic disease: comprising: 1. Electrolyte imbalance, 2. liver, renal failure and Reye syndrome, 3. hereditary metabolic disorders, 4. poisoning.
Therapeutic Principle: with heat clearing away, eliminating phlegm, relieving convulsion, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. as Therapeutic Principle.The necessary eliminating phlegm of abundant expectoration person, frightened Sheng person must be relieving convulsion, and wind Sheng person must relieve dizziness, high fever, infantile convulsions, epilepsy, etc., and right intenseness of heat person all must be first antipyretic.Because expectorant has phlegm-fire and the turbid difference of expectorant; Heat has the difference of the exterior and the interior; Wind has the difference of exogenous wind, endogenous wind; Both can there is the excess syndrome startling, yelp in infantile convulsion, also can occur fear, frightened cautious deficiency syndrome.Therefore, eliminating phlegm has causing resuscitation with aromatic drugs, clearing away fire and eliminating phlegm, the differentiation of clearing away phlegm purging FU-organs; Heat clearing away has expelling pathogenic factors from muscles expelling pathogenic factors from the exterior, Qi cleaning and heat releasing, the difference of clearing away heat from YING and blood systems; Control the classification that wind has dispelling wind, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., relieving convulsion have the arresting convulsion that clears away heart-fire, and nourish heart flat frightened difference.Doctor trained in Western medicine process: 1. bring down a fever: Physical temperature-lowering can use headrest ice bag, and warm and humid towel is rubbed one's body with a towel, 40%-50% alcohol bath.Drug cooling can with Metamizole nasal drip or intramuscular injection.2. spasmolytic first-selection is stable, also can use phenobarbital 8-lOmg/kS intramuscular injection or 5% chloral hydrate 50rog/kS retention enema.3. reduce intracranial pressure: tic time remaining more than 15 minutes or repeatedly Children with Convulsion, cerebral edema can occur.Conventional 20% mannitol 1-26/ks, in 20-30 minute, rapid intravenous instils or intravenous injection.6-8 hour repeats 1 time.
Application publication number CN 103816417 A(application number 201410065446.2) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of infantile convulsion, comprise the crude drug of following parts by weight: Aloe, Arisaema Cum Bile, Concretio Silicea Bambusae, Realgar, the Rhizoma Pinelliae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Ramulus Uncariae Cum Uncis, succinum, Cinnabaris, Rhizoma dioscoreae, Cornu Saigae Tataricae, Radix Angelicae Sinensis, Semen Persicae, Herba hylotelephii erythrosticti, Exocarpium Citri Rubrum.Application publication number CN 103860830 A(application number 201410142914.1) Chinese patent literature disclose a kind of Chinese medicine preparation and preparation method for the treatment of infantile convulsion, the raw material making described Chinese medicine preparation effective ingredient consists of: Radix Serissae, Fel Bovis seu Bubali, Rhizoma Acori Calami, Rhizoma Paridis, cicada, Drymotaenium miyoshianum (Mak.) Mak., Herba rutae, Fructus Benincasae, female's gold reed, Flos nymphaeae (Nymphaea teragona Georgi), Radix Rhododendri, xanthorrhiza, Herba hylotelephii erythrosticti, elaeagnus conferta fruits, Cortex Betulae Luminiferae and Folium Eriobotryae.Application publication number CN 103830669 A(application number 201410052802.7) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of infantile convulsion, the weight portion of its constitutive material is: Radix Ophiopogonis 11-12, Fructus Corni 8-10, Semen Raphani 5-7, Flos Lonicerae 4-6, Radix Curcumae 3-4, Radix Glycyrrhizae 2-4, Radix Polygalae 4-6, Rhizoma Gastrodiae 4-6, Ramulus Uncariae Cum Uncis 2-4, Ramulus Luffae 10-12, Caulis Cucumidis sativiv 10-12, Herba stellariae mediae 4-5, GUOQIANGFENG 2-4, Herba Calthae Membranaceae 4-6, Herba Murdanniae Triquetrae 1-3, Herba Acroptili repentis 6-8 and Herba Dichondrae Repentis 2-3.
At present, treatment infantile convulsion does not have specific drug, and the traditional Chinese medical science generally adopts relieving convulsion medicine, and doctor trained in Western medicine is generally to take medicine infusion treatment, and take effect slow, treatment cycle is long, and side effect is large, and cures the symptoms, not the disease, and easily recurs.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of infantile convulsion eliminating pestilence and relieving toxicity medicament and preparation method thereof.Instant effect of the present invention, treatment time be short, safely, have no side effect, treating both the principal and secondary aspects of a disease, not easily to recur.
Technical scheme of the present invention is:
Infantile convulsion eliminating pestilence and relieving toxicity medicament, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 12-25, Herba Polygalae Japonicae 6-10, Rhizoma Coptidis 4-8, tylophora florlbunda 6-9, Fructus Gardeniae 10-20, Herba Peristrophes 5-10, Ramulus Uncariae Cum Uncis 7-12, the blue or green 8-15 of straw sandals, succinum 3-5, Rhizoma Anemarrhenae 9-12, Calculus Equi 2-6, Caulis et Folium Abri 5-10.
Infantile convulsion eliminating pestilence and relieving toxicity medicament, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 15-20, Herba Polygalae Japonicae 7-9, Rhizoma Coptidis 5-7, tylophora florlbunda 7-8.5, Fructus Gardeniae 12-17, Herba Peristrophes 6-9, Ramulus Uncariae Cum Uncis 8-10, the blue or green 10-13 of straw sandals, succinum 3.5-4.5, Rhizoma Anemarrhenae 10-11.5, Calculus Equi 3-5, Caulis et Folium Abri 6-8.
Infantile convulsion eliminating pestilence and relieving toxicity medicament, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 17, Herba Polygalae Japonicae 8, Rhizoma Coptidis 6, tylophora florlbunda 8, Fructus Gardeniae 15, Herba Peristrophes 7, Ramulus Uncariae Cum Uncis 9, straw sandals green grass or young crops 11, succinum 4, the Rhizoma Anemarrhenae 10.5, Calculus Equi 4, Caulis et Folium Abri 7.
Present invention also offers the preparation method above-mentioned infantile convulsion eliminating pestilence and relieving toxicity medicament being made pharmaceutically acceptable decoction, pill and thick paste agent.
The preparation method of described decoction is:
(1) clean Calculus Equi and succinum smashed to pieces be respectively ground into fine powder, cross 150-190 mesh sieve (preferred, cross 160-180 mesh sieve; Be more preferably, cross 170 mesh sieves);
(2) put by rice in hot pot, add to propagandize hotly stir to dropping into Fructus Forsythiae when smoldering with moderate heat, it is preferred that every 100kg Fructus Forsythiae adds meter 15-25kg(, and every 100kg Fructus Forsythiae adds a meter 17-23kg; Be more preferably, every 100kg Fructus Forsythiae adds a meter 21kg), be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, cross 150-190 mesh sieve and (preferably, cross 160-180 mesh sieve; Be more preferably, cross 170 mesh sieves);
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite, add water after cleaning, amount of water is that doubly (preferred, amount of water is 3.5-4.5 times of 9 taste Chinese crude drug weight to the 3-5 of 9 taste Chinese crude drug weight; Be more preferably, amount of water is 4 times of 9 taste Chinese crude drug weight), first boil with high heat to boiling, after turn slow fire boiling 30-50 minute (preferred, after turn slow fire boiling 35-45 minute; Be more preferably, after turn slow fire boiling 42 minutes), leach medicinal liquid;
(4) step (1) and step (2) gained fine powder are joined in step (3) gained medicinal liquid.
The preparation method of described pill is:
(1) clean Calculus Equi and succinum smashed to pieces be respectively ground into fine powder, cross 100-140 mesh sieve (preferred, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) put by rice in hot pot, add to propagandize hotly stir to dropping into Fructus Forsythiae when smoldering with moderate heat, it is preferred that every 100kg Fructus Forsythiae adds meter 15-25kg(, and every 100kg Fructus Forsythiae adds a meter 17-23kg; Be more preferably, every 100kg Fructus Forsythiae adds a meter 21kg), be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite, add water after cleaning, amount of water is that doubly (preferred, amount of water is 5-6 times of 9 taste Chinese crude drug weight to the 4.5-6.5 of 9 taste Chinese crude drug weight; Be more preferably, amount of water is 5.5 times of 9 taste Chinese crude drug weight), first boil with high heat to boiling, after turn slow fire boiling 50-80 minute (preferred, after turn slow fire boiling 60-70 minute; Be more preferably, after turn slow fire boiling 65 minutes), leach medicinal liquid;
(4) step (3) gained concentration of liquid medicine is become relative density be 1.20-1.30 clear paste (preferred, step (3) gained concentration of liquid medicine become relative density to be the clear paste of 1.24-1.28; Be more preferably, step (3) gained concentration of liquid medicine is become relative density be 1.26 clear paste), then add refined honey, it is preferred that every 100kg clear paste adds refined honey 140-180kg(, and every 100kg clear paste adds refined honey 150-170kg; Be more preferably, every 100kg clear paste adds refined honey 160kg), after cooling, add step (1) and step (2) gained fine powder, stir, make honeyed pill, the weight of every ball is 0.1-0.3 gram, and (preferred, the weight of every ball is 0.12-0.25 gram; Be more preferably, the weight of every ball is 0.15 gram).
The preparation method of described thick paste agent is:
(1) clean Calculus Equi and succinum smashed to pieces be respectively ground into fine powder, cross 120-160 mesh sieve (preferred, cross 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);
(2) put by rice in hot pot, add to propagandize hotly stir to dropping into Fructus Forsythiae when smoldering with moderate heat, it is preferred that every 100kg Fructus Forsythiae adds meter 18-30kg(, and every 100kg Fructus Forsythiae adds a meter 22-27kg; Be more preferably, every 100kg Fructus Forsythiae adds a meter 25kg), be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, cross 120-160 mesh sieve and (preferably, cross 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite, add water after cleaning, amount of water is that doubly (preferred, amount of water is 4.5-6.5 times of 9 taste Chinese crude drug weight to the 4-7 of 9 taste Chinese crude drug weight; Be more preferably, amount of water is 5.2 times of 9 taste Chinese crude drug weight), first boil with high heat to boiling, after turn slow fire boiling 50-70 minute (preferred, after turn slow fire boiling 55-65 minute; Be more preferably, after turn slow fire boiling 60 minutes), leach medicinal liquid, medicinal liquid is left standstill 4-8 hour (preferred, medicinal liquid is left standstill 5-7 hour; Be more preferably, medicinal liquid left standstill 6 hours), obtain filtrate;
(4) step (3) gained filtrate is concentrated into thick paste that relative density is 1.32-1.38 (preferred, step (3) gained concentration of liquid medicine become relative density to be the thick paste of 1.34-1.36; Be more preferably, step (3) gained concentration of liquid medicine is become relative density be 1.35 thick paste), add refined honey, it is preferred that every 100kg thick paste adds refined honey 140-170kg(, and every 100kg thick paste adds refined honey 150-160kg; Be more preferably, every 100kg thick paste adds refined honey 155kg), then step (1) and step (2) gained fine powder are added mix well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.
Infantile convulsion eliminating pestilence and relieving toxicity drug prescription science provided by the invention, preparation method is simple.In addition, excellent results of the present invention also shows:
1, instant effect, treatment time are short;
2, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, adopt treatment by Chinese herbs can play the effect that As the medicine took effect, the symptoms lessened, treating both the principal and secondary aspects of a disease, safely, to have no side effect;
3, there is heat clearing and damp drying, pathogenic fire purging relieving restlessness, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. the effects such as arresting convulsion, tranquillizing the mind by relieving convulsion, heat-clearing and toxic substances removing, for treatment children's
Infantile convulsion Be very effective;
4, while treatment protopathy, also can make to make liver-wind put down and put out, equilibrium between yin and yang, avoids infantile convulsion to show effect once again.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Forsythiae: base is former: be the dry fruit of Oleaceae plants Fructus Forsythiae.The property of medicine: bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Herba Polygalae Japonicae: base is former: be herb or the root of milk wort Herba Polygalae Japonicae.Chemical analysis: root is containing triterpenoid saponin, resin, fatty oil, polygalytol.The property of medicine: bitter, micro-pungent, flat.Return lung, stomach, heart channel.Function cures mainly: the hemostasis of expelling phlegm for arresting cough, dissipating blood stasis, mind tranquilizing and the heart calming, removing toxic substances and promoting subsidence of swelling.Main cough with copious phlegm, traumatic injury, rheumatic arthralgia, spit blood, have blood in stool, cardiopalmus, insomnia, laryngopharynx swelling and pain, carbuncle skin infection, venom.
Rhizoma Coptidis: another name: taste company, Rhizoma Coptidis, Rhizoma Coptidis, base is former: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.The property of medicine: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Tylophora florlbunda: base is former: be the root of asclepiadaceae Tylophora plant tylophora florlbunda.Composition: containing 2,3,5,6-tetramethoxyphenanthro[9,10:6',7' and tylophorine.The property of medicine: pungent, temperature.Mild toxicity.Function cures mainly: dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling.Cure mainly cough with asthma abundant expectoration, diphtheria, infantile convulsion, rheumatic arthralgia, traumatic injury, fracture, venom, carbuncle furuncle, acute conjunctivitis, stomatitis, edema, hepatosplenomegaly.
Fructus Gardeniae: base is former: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.The property of medicine: bitter, cold.GUIXIN, lung, tri-jiao channel.Function cures mainly: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Herba Peristrophes: base is former: be the herb of Acanthaceae Herba Peristrophes platymiscium Herba Peristrophes.Composition: aerial parts is containing the black alcohols of plant: lupeol, stigmasterol, cupreol glucosides, cupreol glucoside.Pharmacology: antibacterial action: Herba Peristrophes has stronger inhibitory action to staphylococcus aureus, Hemolytic streptococcus, the false single bacteria of Aerugo, klebsiella pneumoniae.The property of medicine: pungent, cool.Function cures mainly: expelling wind and clearing away heat, cool liver arresting convulsion, removing toxic substances and promoting subsidence of swelling.Cure mainly cold, fever, lung-heat cough with asthma, liver-heat conjunctival congestion, infantile convulsion, laryngopharynx swelling and pain, toxic swelling, hemorrhoid, snake bite and insect sting, traumatic injury.
Ramulus Uncariae Cum Uncis: base is former: be Maguireothamnus speciosus Ramulus Uncariae Cum Uncis or Uncaria sinensis (Oliv.) Havil. and the buckle branch belonging to various plants together thereof.Main component: containing an ancient unit of weight rattan alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali, hirsutine, hirsuteine.Different Ramulus Uncariae Cum Uncis, corynoxein, different corynoxein, hair 9-methoxycorynantheidine., dehydrogenation hair 9-methoxycorynantheidine., pocket HUAMU alkali and dihydro pocket HUAMU alkali.The property of medicine: sweet, cool.Return liver, heart channel.Function cures mainly: heat clearing away suppressing the hyperactive liver, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Control pediatric epilepsy scared Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclamposia.
Straw sandals are blue or green: base is former: be the herb of Thelypteridaceae Parathelypteris glanduligera (Kunze) Ching platymiscium Pronephrium simplex.The property of medicine: sweet, micro-puckery, cool.Function cures mainly: heat-clearing and toxic substances removing.Cure mainly laryngopharynx swelling and pain, dysentery, venom.
Succinum: base is former: be the resin of Pinaceae pine genus plant in ancient times, is imbedded in the fossil sample material that underground is transformed year in year out for a long time.Composition: mainly resinous, volatile oil, diabietionlic acid, succinosilvic acid, amber tree fat acid, succinoabietol, succinic acid, Borneolum Syntheticum etc.The property of medicine: sweet, flat.GUIXIN, liver, urinary bladder channel.Function cures mainly: tranquillizing the mind by relieving convulsion, and dissipating blood stasis stops blooding, relieving stranguria by diuresis, nebula of dispelling improving eyesight.Cure mainly insomnia, palpitation with fear, infantile convulsion, epilepsy, congestion amenorrhea, puerperal abdonimal pain ， lumps in the chest and abdomen, stranguria with blood hematuria, the raw cataracta of order.Compatibility and incompatibility of drugs: yin asthenia generating intrinsic heat and without the careful clothes of the stagnant person of the stasis of blood.
The Rhizoma Anemarrhenae: base is former: be the rhizome of the liliaceous plant Rhizoma Anemarrhenae.Chemical composition: main containing Saponin.Rhizome is containing Total saponin about 6%, therefrom detect 6 kinds of Saponins, be called zhimusaponin A-I, A-II, A-III, A-IV, B-I and B-II, wherein zhimusaponin A-III is the disaccharidase glycoside that Sa Ersa ruscogenin and timobiose are combined into, and zhimusaponin A-I is Sa Ersa ruscogenin β-D-galactopyranosyl glucoside.Ruscogenin in Asphodeloides Bge Rhizome is Sa Ersa ruscogenin mainly, the content in dry root about 0.5%, also has markogenin, new gitogenin in addition.The Saponin separated from Asphodeloides Bge Rhizome in the past was once called Chinonin, inferred that is that right that examines the mixture of Saponin, zhimusaponin A-III, A-IV, B etc.Rhizome is still containing reducing sugar and phlegmatic temperament, tannic acid, the fatty wet goods of volume, and every gram contains nicotinic acid 188 microgram again.Niacin amide 12 microgram.Another containing Mengiferin 0.5%.Aerial parts is containing Mengiferin and isomangiferin.Leaf is containing Mengiferin about 0.7%.Flower, containing Saponin, obtains the glycoside unit C that fusing point is 246 ~ 248 DEG C after hydrolysis 27h 42o 4.The property of medicine: bitter, cold.Return lung, stomach, kidney channel.Function cures mainly: nourishing YIN to lower pathogenic fire, moisturizes laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Compatibility and incompatibility of drugs: Deficiency and coldness of spleen and stomach, diarrhea with loose stool person prohibits clothes.
Calculus Equi: base is former: be the gastrointestinal tract calculus of equine equus horse.Composition: the calculus phosphoric acid magnesium in horse gastrointestinal, calcium carbonate, magnesium carbonate etc.Ammoniomagnesium phosphate, newberyite.The property of medicine: sweet, salty, cool, mild toxicity.GUIXIN, Liver Channel.Function cures mainly: relieving convulsionly reduce phlegm, heat-clearing and toxic substances removing.Cure mainly infantile convulsion epilepsy, hematemesis and epistaxis, phlegm-heat cough, variola.Compatibility and incompatibility of drugs: 1. " decoction pieces is newly joined ": " invasion by pathogenic cold phlegm-damp person avoids use." 2. " Traditional Chinese Medicine in Sichuan will " nineteen sixty version: " liver, gallbladder meridian avoid use without heat-phlegm person.”
Caulis et Folium Abri: base is former: be the stem and leaf of pulse family Abrus plant Semen Abri Precatorii.Composition: containing triterpene saponin in yearning between lovers cotyledon: Semen Abri Precatorii triterpene glycosides A, B, C, D.Flavonoid: 5,7,4 '-trihydroxy flavane glycosides, star-spangled banner pinaster-3-glucoside, glycyrrhizin, again containing Semen Abri Precatorii lactone A, etc.The property of medicine: " Guangxi Chinese herbal medicine ": " sweet in the mouth, property is put down." function cures mainly: heat-clearing and toxic substances removing, diuresis.Cure mainly flu, laryngopharynx swelling and pain, cough due to lung-heat, acute mastitis, furuncle, hepatitis.
embodiment 1infantile convulsion eliminating pestilence and relieving toxicity medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 30g): Fructus Forsythiae 12 parts, Herba Polygalae Japonicae 6 parts, Rhizoma Coptidis 4 parts, tylophora florlbunda 6 parts, Fructus Gardeniae 10 parts, Herba Peristrophes 5 parts, Ramulus Uncariae Cum Uncis 7 parts, blue or green 8 parts of straw sandals, succinum 3 parts, the Rhizoma Anemarrhenae 9 parts, Calculus Equi 2 parts, Caulis et Folium Abri 5 parts.
The preparation method of above-mentioned infantile convulsion eliminating pestilence and relieving toxicity medicament decoction is:
(1) clean Calculus Equi and succinum are smashed to pieces be respectively ground into fine powder, cross 150 mesh sieves;
(2) rice is put in hot pot, with moderate heat add propagandize hotly to when smoldering drop into Fructus Forsythiae stir, every 100kg Fructus Forsythiae adds a meter 15kg, be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, mistake 150 mesh sieves;
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite after cleaning, add water, amount of water is 3 times of 9 taste Chinese crude drug weight, first boils with high heat to boiling, after turn slow fire boiling 30 minutes, leach medicinal liquid;
(4) step (1) and step (2) gained fine powder are joined in step (3) gained medicinal liquid.
The instructions of taking of decoction of the present invention: oral, less than 1 years old each 4mL ~ 8mL, 1 ~ 6 years old each 12mL ~ 24mL, 7 ~ 14 years old each 25mL ~ 35mL, every day 3 ~ 4 times.As the case may be, in decoction, appropriate white sugar, Mel or crystal sugar can be added, if add white sugar or crystal sugar, after adding, boil 5 minutes again, to kill the miscellaneous bacteria etc. in sugar.
embodiment 2infantile convulsion eliminating pestilence and relieving toxicity medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 30g): Fructus Forsythiae 25 parts, Herba Polygalae Japonicae 10 parts, Rhizoma Coptidis 8 parts, tylophora florlbunda 9 parts, Fructus Gardeniae 20 parts, Herba Peristrophes 10 parts, Ramulus Uncariae Cum Uncis 12 parts, blue or green 15 parts of straw sandals, succinum 5 parts, the Rhizoma Anemarrhenae 12 parts, Calculus Equi 6 parts, Caulis et Folium Abri 10 parts.
The preparation method of above-mentioned infantile convulsion eliminating pestilence and relieving toxicity medicament decoction is:
(1) clean Calculus Equi and succinum are smashed to pieces be respectively ground into fine powder, cross 190 mesh sieves;
(2) rice is put in hot pot, with moderate heat add propagandize hotly to when smoldering drop into Fructus Forsythiae stir, every 100kg Fructus Forsythiae adds a meter 25kg, be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, mistake 190 mesh sieves;
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite after cleaning, add water, amount of water is 5 times of 9 taste Chinese crude drug weight, first boils with high heat to boiling, after turn slow fire boiling 50 minutes, leach medicinal liquid;
(4) step (1) and step (2) gained fine powder are joined in step (3) gained medicinal liquid.
model case one:close XX, man, 3 years old.Before 2 days, infant starts cough, and next day, body temperature reached 39 DEG C, twitches 4 times in half a day, and show as whole body and twitch, continue 1-2 minute, local hospital gives infusion treatment, and the state of an illness fails to alleviate, then medical.Infant full-term normal delivery, birth weight 2.8 kg, neonatal period body is good for.Breast feeding, premature infant, usually easy catching a cold.Have a medical check-up T:38.6 DEG C, body weight 17 kg, unconsciousness.Be diagnosed as " hyperpyrexia convulsion ".Take the present embodiment gained infantile convulsion eliminating pestilence and relieving toxicity medicament decoction, every day 3 times, each 15mL.Take 1 day, temperature recovery is normal.Take 4 days all diseases to disappear, recovery from illness, follows up a case by regular visits to and does not recur so far.
embodiment 3infantile convulsion eliminating pestilence and relieving toxicity medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 30g): Fructus Forsythiae 15 parts, Herba Polygalae Japonicae 7 parts, Rhizoma Coptidis 5 parts, tylophora florlbunda 7 parts, Fructus Gardeniae 12 parts, Herba Peristrophes 6 parts, Ramulus Uncariae Cum Uncis 8 parts, blue or green 10 parts of straw sandals, succinum 3.5 parts, the Rhizoma Anemarrhenae 10 parts, Calculus Equi 3 parts, Caulis et Folium Abri 6 parts.
The preparation method of above-mentioned infantile convulsion eliminating pestilence and relieving toxicity medicament pill is:
(1) clean Calculus Equi and succinum are smashed to pieces be respectively ground into fine powder, cross 120 mesh sieves;
(2) rice is put in hot pot, with moderate heat add propagandize hotly to when smoldering drop into Fructus Forsythiae stir, every 100kg Fructus Forsythiae adds a meter 21kg, be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, mistake 120 mesh sieves;
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite after cleaning, add water, amount of water is 5.5 times of 9 taste Chinese crude drug weight, first boils with high heat to boiling, after turn slow fire boiling 65 minutes, leach medicinal liquid;
(4) step (3) gained concentration of liquid medicine is become relative density be 1.26 clear paste, then add refined honey, every 100kg clear paste adds refined honey 160kg, after cooling, add step (1) and step (2) gained fine powder, stir, make honeyed pill, the weight of every ball is 0.15 gram.
model case two:horse XX, female, 2 years old 9 months.Medical history: started heating before 10 days, move back to local hospital medical transfusion after heat, but spiritual appetite is poor, noon before 8 days generates heat once again, for moderate heat, in afternoon 1 mistake start to occur that extremity are twitched, eyes are stared, should of exhaling, the medicines such as dexamethasone, An Naijing, promethazine, cephalo thiophene trowel used for plastering sodium are given at local hospital, infant tic continues more than about 1 hour side alleviation, but mind does not turn clear yet, about 3 are had a convulsion again, give after quiet note is stabilized and alleviating very soon, when 4: 30, infant sends out tic again again, gradually alleviates after giving 10% hydration dew aldehyde retention enema.Started again heating before 2 days, and again have a convulsion, then medical.Health check-up: T38.3 DEG C, R28bpm, HR120bpm, unconsciousness, gnathospasma, cardiopulmonary (-), abdomen is slightly swollen, and liver spleen is little, and extremity hypermyotonia, neck is soft, and a gram Bu Shi Zheng is feminine gender, is diagnosed as infantile convulsion.Take the present embodiment gained infantile convulsion eliminating pestilence and relieving toxicity medicament pill, each 15 balls, every day 3 times, the head of a family rubs pill broken, becomes soup to feed to infant by warm water molten in little spoon.After taking 1, heat is moved back, and infant mind turns clear.Take 4, recovery from illness, does not recur so far.
embodiment 4infantile convulsion eliminating pestilence and relieving toxicity medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 30g): Fructus Forsythiae 20 parts, Herba Polygalae Japonicae 9 parts, Rhizoma Coptidis 7 parts, tylophora florlbunda 8.5 parts, Fructus Gardeniae 17 parts, Herba Peristrophes 9 parts, Ramulus Uncariae Cum Uncis 10 parts, blue or green 13 parts of straw sandals, succinum 4.5 parts, the Rhizoma Anemarrhenae 11.5 parts, Calculus Equi 5 parts, Caulis et Folium Abri 8 parts.
The preparation method of above-mentioned infantile convulsion eliminating pestilence and relieving toxicity medicament thick paste agent is:
(1) clean Calculus Equi and succinum are smashed to pieces be respectively ground into fine powder, cross 140 mesh sieves;
(2) rice is put in hot pot, with moderate heat add propagandize hotly to when smoldering drop into Fructus Forsythiae stir, every 100kg Fructus Forsythiae adds a meter 25kg, be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, mistake 140 mesh sieves;
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite after cleaning, add water, amount of water is 5.2 times of 9 taste Chinese crude drug weight, first boils with high heat to boiling, after turn slow fire boiling 60 minutes, leach medicinal liquid, medicinal liquid is left standstill 6 hours, obtains filtrate;
(4) step (3) gained filtrate is concentrated into the thick paste that relative density is 1.35, adds refined honey, every 100kg thick paste adds refined honey 155kg, then step (1) and step (2) gained fine powder is added and mix well, and micro-refining, foam removal, seals and get final product in dress aseptic bottle.
model case three:zhao XX, female, 3 years old.Twitch when from birth 9 months, heating reached more than 39 DEG C, annual 2-3 time, each tic 3-4 minute natural remission.Watery nasal discharge before this is medical, to tussicula 2, do not generate heat.Medical quotidian fever of working as reaches 39.5 DEG C, and unexpected whole body is clonic twitches, and loss of consciousness continues 25 minutes.His father and aunt have hyperpyrexia convulsion history childhood, and infant full-term normal delivery first tire, no asphyxia history, growth promoter is good.Physical examination: general status is not good enough, lethargy, irritated, two pulmonary respiration sound strengthens, hear sounds is blunt, rule just, without rale, abdomen is soft.Be diagnosed as infantile convulsion.Take the agent of the present embodiment gained infantile convulsion eliminating pestilence and relieving toxicity medicament thick paste, every day 3 times, each 16g, drink-service washed open by boiled water.Take 1 day, temperature recovery is normal, and mind turns clear.Take 4 days, all diseases disappear, and follow up a case by regular visits to infant without recurrence.
embodiment 5infantile convulsion eliminating pestilence and relieving toxicity medicament, the primary raw material medicine getting following weight parts is prepared from (every part is 30g): Fructus Forsythiae 17 parts, Herba Polygalae Japonicae 8 parts, Rhizoma Coptidis 6 parts, tylophora florlbunda 8 parts, Fructus Gardeniae 15 parts, Herba Peristrophes 7 parts, Ramulus Uncariae Cum Uncis 9 parts, blue or green 11 parts of straw sandals, succinum 4 parts, the Rhizoma Anemarrhenae 10.5 parts, Calculus Equi 4 parts, Caulis et Folium Abri 7 parts.
The preparation method of above-mentioned infantile convulsion eliminating pestilence and relieving toxicity medicament decoction is:
(1) clean Calculus Equi and succinum are smashed to pieces be respectively ground into fine powder, cross 170 mesh sieves;
(2) rice is put in hot pot, with moderate heat add propagandize hotly to when smoldering drop into Fructus Forsythiae stir, every 100kg Fructus Forsythiae adds a meter 21kg, be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, mistake 170 mesh sieves;
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite after cleaning, add water, amount of water is 4 times of 9 taste Chinese crude drug weight, first boils with high heat to boiling, after turn slow fire boiling 42 minutes, leach medicinal liquid;
(4) step (1) and step (2) gained fine powder are joined in step (3) gained medicinal liquid.
test example 1the clinical practice of embodiment 5 gained infantile convulsion eliminating pestilence and relieving toxicity medicament decoction: in April, 2009 in December ,-2011, screen 280 routine infantile convulsion patients in 6 hospitals, female 130 example, wherein male 150 example, oldest 11 years old, minimum 8 months of age, 4.5 years old mean age.Be divided into two groups at random, experimental group and matched group.Experimental group women 66 example, male 74 example, 8 months-11 years old age, 4.5 years old mean age.Matched group women 64 example, male 76 example, 8 months-11 years old age, 4.5 years old mean age.Between two groups of patients, the aspect such as age, clinical diagnosis, performance convulsive attack frequency compares, and no significant difference (P > 0.05), has comparability.Experimental group takes embodiment 5 products obtained therefrom, oral, less than 1 years old each 4mL ~ 8mL, 1 ~ 6 years old each 12mL ~ 24mL, 7 ~ 14 years old each 25mL ~ 35mL, every day 3 ~ 4 times.As the case may be, in decoction, appropriate white sugar, Mel or crystal sugar can be added, if add white sugar or crystal sugar, after adding, boil 5 minutes again, to kill the miscellaneous bacteria etc. in sugar.Matched group uses the medicine of conventional therapy infantile convulsion (as loose in Xiaoer Hulu powder, infantile convulsion, infantile convulsion Anisodus carniolicoides C.Y.Wu et C.Chen, BABAO JINGFENG SAN, Midazolam etc.).Curative effect judging standard: cure: clinical symptom disappearance, main Physico-chemical tests index is normally; Effective: clinical symptoms is eliminated or cardinal symptom is eliminated, and Physico-chemical tests index is normal; Take a turn for the better: cardinal symptom disappears substantially, and main Physico-chemical tests index makes moderate progress.Invalid: main Physico-chemical tests index is front unchanged with treatment.Treat after 5 days, result is as shown in table 1.
Table 1: embodiment 5 gained infantile convulsion eliminating pestilence and relieving toxicity medicament decoction compliance test result
As can be seen from Table 1, the experimental group cure rate using embodiment 5 gained infantile convulsion eliminating pestilence and relieving toxicity medicament decoction is 85%, and total effective rate reaches 98.57%.And the invalid number of cases of matched group is 9 examples, total effective rate is 72.14%.Test shows, the successful of experimental group is better than matched group.
The present invention selects Fructus Forsythiae, Herba Polygalae Japonicae, Rhizoma Coptidis and tylophora florlbunda etc. to carry out compatibility, makes infantile convulsion eliminating pestilence and relieving toxicity medicament.Fructus Forsythiae heat-clearing and toxic substances removing in side, dispersing swelling and dissipating binds.The hemostasis of Herba Polygalae Japonicae expelling phlegm for arresting cough, dissipating blood stasis, mind tranquilizing and the heart calming, removing toxic substances and promoting subsidence of swelling.Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.Tylophora florlbunda dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling.Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Herba Peristrophes expelling wind and clearing away heat, cool liver arresting convulsion, removing toxic substances and promoting subsidence of swelling.Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.The blue or green heat-clearing and toxic substances removing of straw sandals.Succinum tranquillizing the mind by relieving convulsion, dissipating blood stasis stops blooding, relieving stranguria by diuresis, nebula of dispelling improving eyesight.Rhizoma Anemarrhenae nourishing YIN to lower pathogenic fire, moisturizes laxation.Calculus Equi is relieving convulsion to reduce phlegm, heat-clearing and toxic substances removing.Caulis et Folium Abri heat-clearing and toxic substances removing, diuresis.All medicines share, and have heat clearing and damp drying, pathogenic fire purging relieving restlessness, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. the effects such as arresting convulsion, tranquillizing the mind by relieving convulsion, heat-clearing and toxic substances removing, and while treatment protopathy, liver-wind can be made to put down and put out, equilibrium between yin and yang, avoids infantile convulsion to show effect once again.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. infantile convulsion eliminating pestilence and relieving toxicity medicament, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Forsythiae 12-25, Herba Polygalae Japonicae 6-10, Rhizoma Coptidis 4-8, tylophora florlbunda 6-9, Fructus Gardeniae 10-20, Herba Peristrophes 5-10, Ramulus Uncariae Cum Uncis 7-12, the blue or green 8-15 of straw sandals, succinum 3-5, Rhizoma Anemarrhenae 9-12, Calculus Equi 2-6, Caulis et Folium Abri 5-10.
2. infantile convulsion eliminating pestilence and relieving toxicity medicament as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Forsythiae 15-20, Herba Polygalae Japonicae 7-9, Rhizoma Coptidis 5-7, tylophora florlbunda 7-8.5, Fructus Gardeniae 12-17, Herba Peristrophes 6-9, Ramulus Uncariae Cum Uncis 8-10, the blue or green 10-13 of straw sandals, succinum 3.5-4.5, Rhizoma Anemarrhenae 10-11.5, Calculus Equi 3-5, Caulis et Folium Abri 6-8.
3. infantile convulsion eliminating pestilence and relieving toxicity medicament as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Forsythiae 17, Herba Polygalae Japonicae 8, Rhizoma Coptidis 6, tylophora florlbunda 8, Fructus Gardeniae 15, Herba Peristrophes 7, Ramulus Uncariae Cum Uncis 9, straw sandals green grass or young crops 11, succinum 4, the Rhizoma Anemarrhenae 10.5, Calculus Equi 4, Caulis et Folium Abri 7.
4. the infantile convulsion eliminating pestilence and relieving toxicity medicament as described in as arbitrary in claims 1 to 3, it is characterized in that, this infantile convulsion eliminating pestilence and relieving toxicity medicament is made pharmaceutically acceptable decoction, and the preparation method of described decoction is:
(1) clean Calculus Equi and succinum smashed to pieces be respectively ground into fine powder, cross 150-190 mesh sieve (preferred, cross 160-180 mesh sieve; Be more preferably, cross 170 mesh sieves);
(2) put by rice in hot pot, add to propagandize hotly stir to dropping into Fructus Forsythiae when smoldering with moderate heat, it is preferred that every 100kg Fructus Forsythiae adds meter 15-25kg(, and every 100kg Fructus Forsythiae adds a meter 17-23kg; Be more preferably, every 100kg Fructus Forsythiae adds a meter 21kg), be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, cross 150-190 mesh sieve and (preferably, cross 160-180 mesh sieve; Be more preferably, cross 170 mesh sieves);
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite, add water after cleaning, amount of water is that doubly (preferred, amount of water is 3.5-4.5 times of 9 taste Chinese crude drug weight to the 3-5 of 9 taste Chinese crude drug weight; Be more preferably, amount of water is 4 times of 9 taste Chinese crude drug weight), first boil with high heat to boiling, after turn slow fire boiling 30-50 minute (preferred, after turn slow fire boiling 35-45 minute; Be more preferably, after turn slow fire boiling 42 minutes), leach medicinal liquid;
(4) step (1) and step (2) gained fine powder are joined in step (3) gained medicinal liquid.
5. the infantile convulsion eliminating pestilence and relieving toxicity medicament as described in as arbitrary in claims 1 to 3, it is characterized in that, this infantile convulsion eliminating pestilence and relieving toxicity medicament is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) clean Calculus Equi and succinum smashed to pieces be respectively ground into fine powder, cross 100-140 mesh sieve (preferred, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) put by rice in hot pot, add to propagandize hotly stir to dropping into Fructus Forsythiae when smoldering with moderate heat, it is preferred that every 100kg Fructus Forsythiae adds meter 15-25kg(, and every 100kg Fructus Forsythiae adds a meter 17-23kg; Be more preferably, every 100kg Fructus Forsythiae adds a meter 21kg), be strong yellow to rice, take out, sift out rice, cool, be ground into fine powder, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite, add water after cleaning, amount of water is that doubly (preferred, amount of water is 5-6 times of 9 taste Chinese crude drug weight to the 4.5-6.5 of 9 taste Chinese crude drug weight; Be more preferably, amount of water is 5.5 times of 9 taste Chinese crude drug weight), first boil with high heat to boiling, after turn slow fire boiling 50-80 minute (preferred, after turn slow fire boiling 60-70 minute; Be more preferably, after turn slow fire boiling 65 minutes), leach medicinal liquid;
(4) step (3) gained concentration of liquid medicine is become relative density be 1.20-1.30 clear paste (preferred, step (3) gained concentration of liquid medicine become relative density to be the clear paste of 1.24-1.28; Be more preferably, step (3) gained concentration of liquid medicine is become relative density be 1.26 clear paste), then add refined honey, it is preferred that every 100kg clear paste adds refined honey 140-180kg(, and every 100kg clear paste adds refined honey 150-170kg; Be more preferably, every 100kg clear paste adds refined honey 160kg), after cooling, add step (1) and step (2) gained fine powder, stir, make honeyed pill, the weight of every ball is 0.1-0.3 gram, and (preferred, the weight of every ball is 0.12-0.25 gram; Be more preferably, the weight of every ball is 0.15 gram).
6. the infantile convulsion eliminating pestilence and relieving toxicity medicament as described in as arbitrary in claims 1 to 3, it is characterized in that, this infantile convulsion eliminating pestilence and relieving toxicity medicament is made pharmaceutically acceptable thick paste agent, and the preparation method of described thick paste agent is:
(1) clean Calculus Equi and succinum smashed to pieces be respectively ground into fine powder, cross 120-160 mesh sieve (preferred, cross 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);
(2) put by rice in hot pot, add to propagandize hotly stir to dropping into Fructus Forsythiae when smoldering with moderate heat, every 100kg Fructus Forsythiae adds a meter 18-30kg, be strong yellow to rice, takes out, sifts out rice, cool, be ground into fine powder, cross 120-160 mesh sieve (preferred, 130-150 mesh sieve; Be more preferably, cross 140 mesh sieves);
(3) all the other the 9 taste Chinese crude drugs except Calculus Equi, succinum and Fructus Forsythiae are removed impurity, put into marmite, add water after cleaning, amount of water is that doubly (preferred, amount of water is 4.5-6.5 times of 9 taste Chinese crude drug weight to the 4-7 of 9 taste Chinese crude drug weight; Be more preferably, amount of water is 5.2 times of 9 taste Chinese crude drug weight), first boil with high heat to boiling, after turn slow fire boiling 50-70 minute (preferred, after turn slow fire boiling 55-65 minute; Be more preferably, after turn slow fire boiling 60 minutes), leach medicinal liquid, medicinal liquid left standstill 4-8 hour, obtain filtrate;
(4) step (3) gained filtrate is condensed into the thick paste that relative density is 1.32-1.38, adds refined honey, every 100kg thick paste adds refined honey 140-170kg, again step (1) and step (2) gained fine powder are added and mix well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.
7. the preparation method of infantile convulsion eliminating pestilence and relieving toxicity medicament as claimed in claim 6, is characterized in that, in step (2), every 100kg Fructus Forsythiae adds the preferred every 100kg Fructus Forsythiae of meter 22-27kg(and adds a meter 25kg).
8. the preparation method of infantile convulsion eliminating pestilence and relieving toxicity medicament as claimed in claim 6, is characterized in that, medicinal liquid is left standstill 5-7 hour (preferably medicinal liquid being left standstill 6 hours) in step (3).
9. the preparation method of infantile convulsion eliminating pestilence and relieving toxicity medicament as claimed in claim 6, it is characterized in that, in step (4), step (3) gained filtrate is condensed into the thick paste (preferably step (3) gained filtrate being condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36.
10. the preparation method of infantile convulsion eliminating pestilence and relieving toxicity medicament as claimed in claim 6, is characterized in that, in step (4), every 100kg thick paste adds the preferred every 100kg thick paste of refined honey 150-160kg(and adds refined honey 155kg).
CN201410783168.4A 2014-12-18 2014-12-18 Antipyretic and antitoxic drug for febrile convulsion and preparation method of drug Pending CN104491348A (en)

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CN101797316A (en) * 2010-04-07 2010-08-11 周国生 Traditional Chinese medicine for treating hyperpyrexia and infantile convulsion and preparation method thereof
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