CN104491127A - Health capsules with auxiliary protection function on chemical liver injury and preparation method thereof - Google Patents
Health capsules with auxiliary protection function on chemical liver injury and preparation method thereof Download PDFInfo
- Publication number
- CN104491127A CN104491127A CN201410726653.8A CN201410726653A CN104491127A CN 104491127 A CN104491127 A CN 104491127A CN 201410726653 A CN201410726653 A CN 201410726653A CN 104491127 A CN104491127 A CN 104491127A
- Authority
- CN
- China
- Prior art keywords
- capsule
- liver injury
- glue
- content
- health
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 43
- 231100000753 hepatic injury Toxicity 0.000 title claims abstract description 35
- 206010067125 Liver injury Diseases 0.000 title claims abstract description 30
- 239000000126 substance Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000036541 health Effects 0.000 title abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 23
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229920000159 gelatin Polymers 0.000 claims abstract description 8
- 235000019322 gelatine Nutrition 0.000 claims abstract description 8
- 239000008213 purified water Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 4
- 239000003292 glue Substances 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000007901 soft capsule Substances 0.000 claims description 13
- 239000007766 cera flava Substances 0.000 claims description 10
- 239000002390 adhesive tape Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 108010010803 Gelatin Proteins 0.000 claims description 7
- 239000008273 gelatin Substances 0.000 claims description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims description 7
- 238000005266 casting Methods 0.000 claims description 6
- 239000000084 colloidal system Substances 0.000 claims description 6
- 238000004040 coloring Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 abstract description 10
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 239000002552 dosage form Substances 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 235000013871 bee wax Nutrition 0.000 abstract 1
- 235000013736 caramel Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 235000021388 linseed oil Nutrition 0.000 abstract 1
- 239000000944 linseed oil Substances 0.000 abstract 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 235000013402 health food Nutrition 0.000 description 4
- 230000002440 hepatic effect Effects 0.000 description 4
- 208000019423 liver disease Diseases 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 208000007082 Alcoholic Fatty Liver Diseases 0.000 description 2
- 206010009208 Cirrhosis alcoholic Diseases 0.000 description 2
- 206010016262 Fatty liver alcoholic Diseases 0.000 description 2
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000026594 alcoholic fatty liver disease Diseases 0.000 description 2
- 208000002353 alcoholic hepatitis Diseases 0.000 description 2
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 208000010706 fatty liver disease Diseases 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 235000003969 glutathione Nutrition 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000007863 steatosis Effects 0.000 description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 239000000940 FEMA 2235 Substances 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229930013032 isoflavonoid Natural products 0.000 description 1
- 150000003817 isoflavonoid derivatives Chemical class 0.000 description 1
- 235000012891 isoflavonoids Nutrition 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/55—Linaceae (Flax family), e.g. Linum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Inorganic Chemistry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicine preparations, and aims at providing health capsules with an auxiliary protection function on chemical liver injury and a preparation method thereof. The health capsules especially have a function and a treatment effect of auxiliary protection and incidence prevention for alcoholic liver injury, as well as are good in pharmacological effects, simple in formula and convenient to eat. The contents of the capsules are kudzuvine root extract, schisandra chinensis extract, flaxseed oil and beewax; the raw materials of capsule shells are gelatine, glycerine, purified water, titanium dioxide and caramel colour. The health capsules are searched and developed aiming at risk groups with chemical liver injury, have a great protection effect on chemical liver injury, as well as are reasonable in dosage form selection, convenient to take, going to be popular in masses of consumers, and great in market potential. The health capsules can serve masses of consumers better, and bring good economic benefits to enterprises and countries. The product is predicted to generate great social benefits and economic benefits after being put on the market.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of to chemical liver injury health-caring capsule having auxiliary protection function and preparation method thereof.
Background technology
In recent years, along with the development of Chinese national economy, there is huge change in life style and dietary structure, and alcoholic liver injury has become the main hepatic injury reason being only second to viral hepatitis.Alcoholic liver injury belongs to chemical liver injury category, is due to long-term excessive drinking, makes hepatocyte that steatosis, necrosis and a kind of disease caused by regeneration occur repeatedly.Research finds, the 80 ~ 150g that drinks every day [ethanol (g)=drinking amount (ml) × alcohol content (%) × 0.8 (ethanol density)], can cause hepatic injury in continuous 5 years; Heavy drinking is more than 20 years, and 40% ~ 50% liver cirrhosis can occur.
Excessive drinking is the main cause causing chemical liver injury, alcoholic liver disease (ALD) is the hepatic disease caused by Ethanol intakes a large amount of for a long time, includes the pathological changes such as mild alcoholic liver injury, alcoholic fatty liver, alcoholic hepatitis, alcoholic fibrosis and alcoholic cirrhosis.Along with the raising day by day of domestic level, the increase of the Working Life competitive pressure of people, alcohol to oil ratio significantly increases, the sickness rate of ALD, also in the trend increased year by year, has become second largest hepatopathy in some areas, and Zhejiang Province's Epidemiology of alcoholic liver diseases survey data of 2000 shows: crowd's alcoholic liver disease prevalence is 4.34%, wherein alcoholic cirrhosis is 0.68%, alcoholic hepatitis is 1.51%, and alcoholic fatty liver is 0.94%, and mild alcoholic liver injury is 1.21%.And cause primarily of hepatitis virus due to domestic hepatopathy, hepatitis virus carrier more, may mask and be actually the hepatopathy of ethanol as the cause of disease; Alcoholic liver disease normal and hepatites virus infections mixing existence again simultaneously, plays the effect of causing a disease of superposition, easier concurrent liver cirrhosis and hepatocarcinoma.
As can be seen from various report and research; along with the change of the development of industrial society and people's living habit, mode; the danger coefficient of chemical liver injury is comparatively large, and sickness rate is higher, and people are in the urgent need to having the product of assistant protection function to prevent morbidity and mitigation symptoms to chemical liver injury.
Summary of the invention
The object of this invention is to provide a kind of to chemical liver injury health-caring capsule having auxiliary protection function and preparation method thereof; especially alcoholic liver injury auxiliary protection and prevention morbidity function and therapeutical effect; pharmacological effect is good, and formula simple, be convenient to eat.
The present invention is realized by following technical scheme: a kind of health-caring capsule chemical liver injury being had to auxiliary protection function, and raw material comprises: capsule 's content is: Radix Puerariae extract 135g; Fructus Schisandrae Chinensis extrat 46.5g; Semen Lini oil 301g; Cera Flava 17.5g; The raw material of capsule shells is: gelatin 300g; Glycerol 150g; Purified water 300g; Titanium dioxide 1.77g; Burnt sugar coloring 4.0g.Make 1000,0.5g/ grain.
The preparation method of described capsule is: the preparation of (1) capsule 's content: measure Semen Lini oil and Cera Flava mixing in proportion, heated and stirred is even; Then take Radix Puerariae extract, Fructus Schisandrae Chinensis extrat, add in Cera Flava and Semen Lini oil mixture after crossing 80 mesh sieves, mix homogeneously is for subsequent use; (2) capsule 's content is careful: the capsule 's content access colloid mill of mix homogeneously, and colloid mill grinds 2-3 time, for subsequent use after capsule 's content fine uniform; (3) storing: the capsule 's content of fine uniform is placed in material-compound tank, in material-compound tank ,-0.06 ~ 0.08MPa vacuum keeps one hour, by complete for the bubble of content sucking filtration, after then the mixed material in material-compound tank being crossed 80 eye mesh screens by compressed air, proceed in storage vat for subsequent use; (4) glue skin: in proportion by adding of purified water glue tank, be heated to 50 DEG C, add gelatin, glycerol, burnt sugar coloring, titanium dioxide, seal stirring, be heated to 70 DEG C, stir ,-0.06 ~ 0.08MPa vacuum keeps 1 hour by complete for bubble sucking filtration, after the glue in material-compound tank being crossed 120 eye mesh screens by compressed air, be transferred to be incubated in 60 DEG C of heat-preserving containers for subsequent use; Preheating spread set temperature is 45 DEG C-65 DEG C, opens glue solution barrel end opening valve, and 0.03MPa makes glue continuously flow in two expanding and arranging boxs in left and right through glue conveying box, and glue temperature is 50-60 DEG C; Open port strobe under expanding and arranging box, skin processed on the casting drum that glue flows to rotation, rotary drum inlet temperature 10-20 DEG C, rubber thickness 750-900 μm; The adhesive tape of casting drum exhibition system is stripped out, introduces in the middle of two revolving dies through oil tanker and top guide rod, guide adhesive tape to enter in the middle of stripping wheel, syringe is opened while guiding adhesive tape, electrical bar heats, and setting injector temperature is 35-45 DEG C, and revolving die screw actuates and cuts off rubber and merge; Turn mould rotating speed 0 ~ 3 rev/min, the soft capsule of pelleting molding is sent in soft capsule drying machine by soft capsule conveyer shapes; Setting temperature 8-24 DEG C, humidity≤45%; (6) cleaning, drying: soft capsule pours 95% alcohol washes in the Stainless steel basin of sterilizing, and is transported to the full-automatic drying machine of rotating cage type and carries out drying, control air quantity 3000M
3/ hour, drying machine relative humidity is not more than 35%, baking temperature 20-40 DEG C, speed 8 turns, 2-8 hours drying times.
The present invention is the health food that supplementary material is made by Radix Puerariae extract, Fructus Schisandrae Chinensis extrat, Semen Lini oil, Cera Flava, gelatin, glycerol, purified water, titanium dioxide, caramel color.Modern pharmacological research shows, the isoflavonoid in Radix Puerariae has certain protective effect to liver, can promote liver cell regeneration, promotes bile secretion, strengthens liver detoxification function, prevents ethanol to the damage etc. of liver; Fructus Schisandrae Chinensis can promote the detoxification processes of liver, the liver protecting from murder by poisoning, and can regenerate because of abuse of alcohol, medicine or hepatitis impaired liver organization; The two compatibility, can play good effect, animal function test and toxicological test result show that this product can have significant protective effect to chemical liver injury.This formula is by the combined effect of each raw material thus the auxiliary protection function reached chemical liver injury.Product processes is scientific and reasonable, steady quality, controlled, for consumer provide a safety, effectively, health food reliably, the health care for Chinese residents will play important effect, have stronger scientific value simultaneously.
Research and develop for chemical liver injury population at risk, have good protective effect to chemical liver injury, and dosage form selection is reasonable, taking convenience, will be subject to consumers in general's favor, have very large market potential.Can better consumers in general be served, can be enterprise and country brings good economic benefit simultaneously.After estimating this launch products, will have a tremendous social and economic benefits.
Detailed description of the invention
Chemical liver injury is had to a health-caring capsule for auxiliary protection function, raw material comprises: capsule 's content is: Radix Puerariae extract 135g; Fructus Schisandrae Chinensis extrat 46.5g; Semen Lini oil 301g; Cera Flava 17.5g; The raw material of capsule shells is: gelatin 300g; Glycerol 150g; Purified water 300g; Titanium dioxide 1.77g; Burnt sugar coloring 4.0g.Make 1000,0.5g/ grain.
The preparation method of described capsule is: the preparation of (1) capsule 's content: measure Semen Lini oil and Cera Flava mixing in proportion, heated and stirred is even; Then take Radix Puerariae extract, Fructus Schisandrae Chinensis extrat, add in Cera Flava and Semen Lini oil mixture after crossing 80 mesh sieves, mix homogeneously is for subsequent use; (2) capsule 's content is careful: the capsule 's content access colloid mill of mix homogeneously, and colloid mill grinds 2-3 time, for subsequent use after capsule 's content fine uniform; (3) storing: the capsule 's content of fine uniform is placed in material-compound tank, in material-compound tank ,-0.06 ~ 0.08MPa vacuum keeps one hour, by complete for the bubble of content sucking filtration, after then the mixed material in material-compound tank being crossed 80 eye mesh screens by compressed air, proceed in storage vat for subsequent use; (4) glue skin: in proportion by adding of purified water glue tank, be heated to 50 DEG C, add gelatin, glycerol, burnt sugar coloring, titanium dioxide, seal stirring, be heated to 70 DEG C, stir ,-0.06 ~ 0.08MPa vacuum keeps 1 hour by complete for bubble sucking filtration, after the glue in material-compound tank being crossed 120 eye mesh screens by compressed air, be transferred to be incubated in 60 DEG C of heat-preserving containers for subsequent use; Preheating spread set temperature is 45 DEG C-65 DEG C, opens glue solution barrel end opening valve, and 0.03MPa makes glue continuously flow in two expanding and arranging boxs in left and right through glue conveying box, and glue temperature is 50-60 DEG C; Open port strobe under expanding and arranging box, skin processed on the casting drum that glue flows to rotation, rotary drum inlet temperature 10-20 DEG C, rubber thickness 750-900 μm; The adhesive tape of casting drum exhibition system is stripped out, introduces in the middle of two revolving dies through oil tanker and top guide rod, guide adhesive tape to enter in the middle of stripping wheel, syringe is opened while guiding adhesive tape, electrical bar heats, and setting injector temperature is 35-45 DEG C, and revolving die screw actuates and cuts off rubber and merge; Turn mould rotating speed 0 ~ 3 rev/min, the soft capsule of pelleting molding is sent in soft capsule drying machine by soft capsule conveyer shapes; Setting temperature 8-24 DEG C, humidity≤45%; (6) cleaning, drying: soft capsule pours 95% alcohol washes in the Stainless steel basin of sterilizing, and is transported to the full-automatic drying machine of rotating cage type and carries out drying, control air quantity 3000M
3/ hour, drying machine relative humidity is not more than 35%, baking temperature 20-40 DEG C, speed 8 turns, 2-8 hours drying times.
Experimental example: have the health-caring capsule of auxiliary protection function to check through mouse experiment to chemical liver injury prepared by the present invention, result shows: per os gives the soft capsule 32 days of mice various dose, compare with alcoholic hepatic injury model control group (0g/kgBW), this tested material can reduce triglyceride content (P<0.05) in hepatic tissue in 0.5g/kgBW group, improve reduced glutathion content (P<0.05) in hepatic tissue, triglyceride content (P<0.01) in hepatic tissue can be reduced in 1.50g/kgBW group, improve reduced glutathion content (P<0.01) in hepatic tissue, reduce steatosis average mark (P<0.05).Tested material increases to Mouse Weight the basis " health food inspection and assessment technical specification " (2003 editions) that has no adverse effects; there is the criterion of assistant protection function (alcoholic hepatic injury model) health food known to chemical liver injury; have the health-caring capsule of auxiliary protection function to have assistant protection function (alcoholic hepatic injury model) to chemical liver injury to chemical liver injury prepared by the present invention, results of animal is positive.
Claims (3)
1. chemical liver injury is had to a health-caring capsule for auxiliary protection function, it is characterized in that: the raw material that every 1000 capsules medicines adopt comprises: capsule 's content is: Radix Puerariae extract 135g; Fructus Schisandrae Chinensis extrat 46.5g; Semen Lini oil 301g; Cera Flava 17.5g; The raw material of capsule shells is: gelatin 300g; Glycerol 150g; Purified water 300g; Titanium dioxide 1.77g; Burnt sugar coloring 4.0g.
2. a kind of health-caring capsule chemical liver injury being had to auxiliary protection function according to claim 1, is characterized in that: described capsule 0.5g/ grain.
3. a kind of health-caring capsule chemical liver injury being had to auxiliary protection function according to claim 1 and 2, it is characterized in that: the preparation method of described capsule is: the preparation of (1) capsule 's content: measure Semen Lini oil and Cera Flava mixing in proportion, heated and stirred is even; Then take Radix Puerariae extract, Fructus Schisandrae Chinensis extrat, add in Cera Flava and Semen Lini oil mixture after crossing 80 mesh sieves, mix homogeneously is for subsequent use; (2) capsule 's content is careful: the capsule 's content access colloid mill of mix homogeneously, and colloid mill grinds 2-3 time, for subsequent use after capsule 's content fine uniform; (3) storing: the capsule 's content of fine uniform is placed in material-compound tank, in material-compound tank ,-0.06 ~ 0.08MPa vacuum keeps one hour, by complete for the bubble of content sucking filtration, after then the mixed material in material-compound tank being crossed 80 eye mesh screens by compressed air, proceed in storage vat for subsequent use; (4) glue skin: in proportion by adding of purified water glue tank, be heated to 50 DEG C, add gelatin, glycerol, burnt sugar coloring, titanium dioxide, seal stirring, be heated to 70 DEG C, stir ,-0.06 ~ 0.08MPa vacuum keeps 1 hour by complete for bubble sucking filtration, after the glue in material-compound tank being crossed 120 eye mesh screens by compressed air, be transferred to be incubated in 60 DEG C of heat-preserving containers for subsequent use; Preheating spread set temperature is 45 DEG C-65 DEG C, opens glue solution barrel end opening valve, and 0.03MPa makes glue continuously flow in two expanding and arranging boxs in left and right through glue conveying box, and glue temperature is 50-60 DEG C; Open port strobe under expanding and arranging box, skin processed on the casting drum that glue flows to rotation, rotary drum inlet temperature 10-20 DEG C, rubber thickness 750-900 μm; The adhesive tape of casting drum exhibition system is stripped out, introduces in the middle of two revolving dies through oil tanker and top guide rod, guide adhesive tape to enter in the middle of stripping wheel, syringe is opened while guiding adhesive tape, electrical bar heats, and setting injector temperature is 35-45 DEG C, and revolving die screw actuates and cuts off rubber and merge; Turn mould rotating speed 0 ~ 3 rev/min, the soft capsule of pelleting molding is sent in soft capsule drying machine by soft capsule conveyer shapes; Setting temperature 8-24 DEG C, humidity≤45%; (6) cleaning, drying: soft capsule pours 95% alcohol washes in the Stainless steel basin of sterilizing, and is transported to the full-automatic drying machine of rotating cage type and carries out drying, control air quantity 3000M
3/ hour, drying machine relative humidity is not more than 35%, baking temperature 20-40 DEG C, speed 8 turns, 2-8 hours drying times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410726653.8A CN104491127A (en) | 2014-12-04 | 2014-12-04 | Health capsules with auxiliary protection function on chemical liver injury and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410726653.8A CN104491127A (en) | 2014-12-04 | 2014-12-04 | Health capsules with auxiliary protection function on chemical liver injury and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104491127A true CN104491127A (en) | 2015-04-08 |
Family
ID=52932641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410726653.8A Pending CN104491127A (en) | 2014-12-04 | 2014-12-04 | Health capsules with auxiliary protection function on chemical liver injury and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104491127A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106722862A (en) * | 2016-11-11 | 2017-05-31 | 延边韩工坊健康制品有限公司 | A kind of liver protecting capsule health food containing and preparation method thereof |
| CN108295116A (en) * | 2018-02-09 | 2018-07-20 | 南京邦康生物技术有限公司 | A kind of selenium-enriched health care composition, capsule and preparation method thereof |
| CN112220885A (en) * | 2020-11-18 | 2021-01-15 | 生升美高科技(武汉)有限责任公司 | Traditional Chinese medicine composition for protecting gastric mucosa and preparation method and application thereof |
| CN115671182A (en) * | 2022-07-21 | 2023-02-03 | 陕西中医药大学 | Pharmaceutical composition for preventing and/or treating acute liver injury and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349291A (en) * | 2013-06-24 | 2013-10-16 | 汤臣倍健股份有限公司 | Composition and capsule with good stability and function of improving faculty of memory and preparation method thereof |
-
2014
- 2014-12-04 CN CN201410726653.8A patent/CN104491127A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349291A (en) * | 2013-06-24 | 2013-10-16 | 汤臣倍健股份有限公司 | Composition and capsule with good stability and function of improving faculty of memory and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 任晓文: "《药物制剂工艺及设备选型》", 31 January 2010, 化学工业出版社 * |
| 栾玉泉等: "葛根提取物对酒精性肝损伤大鼠肝组织TNF-α表达变化的研究", 《大理学院学报》 * |
| 王行刚: "《药物制剂设备与操作（固体制剂）》", 31 July 2010, 化学工业出版社 * |
| 赵稳兴等: "小鼠酒精性肝损伤模型的建立及五味子提取物对其作用", 《中国比较医学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106722862A (en) * | 2016-11-11 | 2017-05-31 | 延边韩工坊健康制品有限公司 | A kind of liver protecting capsule health food containing and preparation method thereof |
| CN108295116A (en) * | 2018-02-09 | 2018-07-20 | 南京邦康生物技术有限公司 | A kind of selenium-enriched health care composition, capsule and preparation method thereof |
| CN112220885A (en) * | 2020-11-18 | 2021-01-15 | 生升美高科技(武汉)有限责任公司 | Traditional Chinese medicine composition for protecting gastric mucosa and preparation method and application thereof |
| CN115671182A (en) * | 2022-07-21 | 2023-02-03 | 陕西中医药大学 | Pharmaceutical composition for preventing and/or treating acute liver injury and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104491127A (en) | Health capsules with auxiliary protection function on chemical liver injury and preparation method thereof | |
| CN102199519B (en) | Medicinal vinegar and method for preparing the same | |
| CN106176918A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Radix Puerariae | |
| CN102488733B (en) | Processing method for promoting conversion of ginseng and American ginseng saponins | |
| CN107960508A (en) | A kind of kidney tonifying and dispelling fatigue, the pressed candy for improving sleep | |
| CN105106816B (en) | Protect the traditional Chinese medicine health care product preparation and preparation method thereof of chemical damage | |
| CN101919881A (en) | Preparation method of traditional Chinese medicine ointment | |
| CN111184774A (en) | Corydalis saxicola bunting and application of corydalis saxicola bunting preparation in preparation of drug for treating non-alcoholic fatty liver disease | |
| CN114558049B (en) | Traditional Chinese medicine prescription for treating chronic obstructive pulmonary disease in stationary phase series and application thereof | |
| CN102068473B (en) | Medicinal composition, preparation method, preparation and application thereof | |
| CN104491007A (en) | Preparation method of fructus schisandrae chinensis soft capsule | |
| CN108245654A (en) | A kind of oral liquid for preventing chicken coccidiasis | |
| CN114794277A (en) | Tea composition with effects of reducing fat, reducing blood sugar and reducing uric acid and application thereof | |
| CN108452240A (en) | A kind of antitumor Chinese medicine composition and its application | |
| CN206424624U (en) | A kind of extraction element for being applied to floating class medicinal material | |
| CN101015345A (en) | Health-care food with hypoxia-resistant and immunity-enhancing functions and its preparing process | |
| CN109486633A (en) | Health liquor and tablet and preparation method thereof as made from Herba Cistanches and korean pine seed | |
| CN101732543A (en) | Medicament for treating diseases such as bronchitis, asthma and pharyngitis | |
| CN103859168A (en) | Avian influenza resistant feed additive for large-scale ecological chicken breeding and preparation and use methods thereof | |
| CN106309761A (en) | Pharmaceutical composition for treating avian infectious broncheitis and preparation method of microcapsules of pharmaceutical composition | |
| CN113181256B (en) | Traditional Chinese medicine composition for treating liver fibrosis | |
| CN115944700B (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN108888658A (en) | A kind of hair-growing hair-blackening liquid and preparation method thereof and application method | |
| CN103844250A (en) | Tortoise/soft-shelled turtle dipping wine and preparation methods thereof | |
| CN106728899A (en) | A kind of compound roxburgh anoectochilus terminal bud relieving alcoholism and protecting liver lozenge and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150408 |