CN103349291A - Composition and capsule with good stability and function of improving faculty of memory and preparation method thereof - Google Patents
Composition and capsule with good stability and function of improving faculty of memory and preparation method thereof Download PDFInfo
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- CN103349291A CN103349291A CN2013102535393A CN201310253539A CN103349291A CN 103349291 A CN103349291 A CN 103349291A CN 2013102535393 A CN2013102535393 A CN 2013102535393A CN 201310253539 A CN201310253539 A CN 201310253539A CN 103349291 A CN103349291 A CN 103349291A
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Abstract
The invention provides a composition with good stability and a function of improving the faculty of memory. The composition comprises phosphatidylserine, ginkgo biloba extract, vitamin, vitamin, folic acid, linseed oil, beewax and vitamin. The invention also provides a capsule with good stability and a function of improving the faculty of memory and a preparation method thereof. By the composition with good stability and a function of improving the faculty of memory provided by the invention, the faculty of memory can be obviously improved; and the product has the technical effects of good stability and the like.
Description
Technical field
The present invention relates to health products, particularly a kind of good stability improves memory composition, capsule and preparation method.
Background technology
Raising along with people's living standard, life stress is also increasing, the elderly's memory is along with the aging of each organ of health gone down with very slow speed, this is the natural law, it also is normal phenomenon, and the general failure of memory of the elderly has appearred in now a lot of young men, and this has to cause our attention.The unhealthy emotion that operating pressure causes greatly affects our thinking, also affects our memory simultaneously, causes occurring failure of memory, and in addition, insomnia, disease, age, pressure all can cause decrease of memory in various degree.
Much improve now the product of memory on the market plane, but between its composition the material compatibility use can not obtain stability higher improve the memory product.The existing product ubiquity only can improve the problem that memory material simple combination is not considered storeroom compatibility and stability.Therefore, the defectives such as rotten, that stability is low, active constituent content is low appear in product easily.The invention reside in and seek a kind ofly can improve memory and the higher product of stability.The application of this patent helps to remedy the blank of this part.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of memory of improving, and the composition of good stability and capsule preparations thereof.
What the invention provides a kind of good stability improves the memory composition, comprising: ginkgo biloba p.e, phosphatidylserine, linseed oil.Described three kinds of mutual compatibilities of component can effectively improve memory, and keep preferably stability.
Further, said composition also comprises vitamin B1, vitamin B6, folic acid, beeswax and vitamin E.
Further, by weight composed of the following components: phosphatidylserine 125-135 part, ginkgo biloba p.e 95-105 part, vitaminB10 .9-1.1 part, vitamin B6 0.9-1.1 part, folic acid 0.13-0.17 part, linseed oil 331.6-366.5 part, beeswax 16.5-20.1 part, vitamin E 0.45-0.55 part.
The component preferred version is: 130 parts of phosphatidylserines, 100 parts of ginkgo biloba p.es, VB11 .0 part, 1.0 parts of vitamin B6s, 0.15 part in folic acid, 349.05 parts of linseed oil, 18.3 parts in beeswax, 0.5 part of vitamin E.
The present invention also provides a kind of capsule that improves memory, is comprised of described composition and the capsule skin that improves memory.
Further, described capsule skin is by weight composed of the following components: gelatin 221-244 part, glycerine 90.5-100 part, burnt sugar coloring 3.65-4.45 part, titanium dioxide 0.5-0.6 part, purified water 206.7-228.5 part.
Further, described capsule skin is by weight composed of the following components: 232.5 parts in gelatin, 95.32 parts of glycerine, 4.05 parts of burnt sugar colorings, 0.55 part of titanium dioxide, 217.6 parts of purified water.
Also provide a kind of preparation method who improves the capsule of memory in the present invention, may further comprise the steps:
S1. glue capsule skin:
A. with glycerine 90.5-100 part, purified water 206.7-228.5 part, gelatin 221-244 part inputization glue tank, be heated to 70-80 ℃ of colloidal sol, get sol solutions;
B. again titanium dioxide 0.5-0.6 part, burnt sugar coloring 3.65-4.45 part are dropped into sol solutions and stirred, constant temperature stirred 40-50 minute, got the glue mixed material;
C. the glue mixed material is vacuumized, more than control vacuum-0.06Mpa, close vacuum, open air bleeding valve, detect the glue viscosity at 2.0 ten thousand-3.5 ten thousand mPa s;
D. glue is crossed 80-100 order filter bag; Glue 50-65 ℃ insulation, for subsequent use;
S2. composition processed: get linseed oil 331.6-366.5 part, beeswax 16.5-20.1 part, vitaminB10 .9-1.1 part, vitamin B6 0.9-1.1 part, vitamin E 0.45-0.55 part, folic acid 0.13-0.17 part, phosphatidylserine 125-135 part, ginkgo biloba p.e 95-105 part and drop in the material-compound tank, stirred 15-30 minute, get the composition total mixture, grind and filter, for subsequent use;
S3. pelleting: composition, glue are pressed into soft capsule in rolling the pattern encapsulating machine;
S4. typing: 18-25 ℃ of control temperature, relative humidity 20-35%'s soft capsule that presses finalized the design 2-5 hour at environment;
S5. dry: with stereotyped capsule at temperature 18-25 ℃, aeration-drying under the relative humidity 20-30% condition.
Adopt composition, capsule and the preparation method who improves memory provided by the invention, mainly improve memory by phosphatidylserine, ginkgo biloba p.e, linseed oil, vitamin B1 and vitamin B6, and strengthen the stablizing effect of product by linseed oil and vitamin E, jointly reach human body and improve memory, the effect that product stability is good.
Phosphatidylserine improves cerebral function, and replenishing phosphatidyl silk amino acid can increase the mobile of brain bur number, brain cell membrane and promote glucose metabolism in the brain cell, thereby makes brain cell more active; Help to repair brain damage, delay the minimizing process of neurotransmitter, help to repair, upgrade the brain damaged cell and remove harmful substance, the level of too much stress hormone improves memory in the person's body that significantly reduces the work strain.
Ginkgo biloba p.e promotes cerebral blood flow and nervous system is had fabulous tonic effect.The effect that hundreds of scientific researches that comprise patients up to ten thousand have confirmed ginkgo biloba p.e is to the effectiveness of the problems of the intelelectual deterioration that comprises the not enough and gerontal patient of brain blood flow.Ginkgo has good effect to the possible symptom of many agings, can obviously improve memory.
Vitamin B1 is called as spirituality vitamin, and nerve fiber and the state of mind are had very important impact, can improve mental status, eliminates tired and improves the effect of memory.
Vitamin B6 can be by regulating monoamine neurotransmitter level in the brain, affects the content of dopamine and serotonin in the brain, improves memory.
Amino acid A wide selection of colours and designs in the linseed protein, essential amino acids content are the higher phytoproteins of a kind of nutritive value up to 5.16%, and linseed and seed oil have higher nutritive value.After deliberation and clinical testing, linseed oil has the compressive resistance of lifting, promotes the effect such as cell health.
Vitamin E has oxidation resistant effect, to acid, heat is all very stable.
That adopts good stability provided by the invention improves memory composition, capsule and preparation method, thereby the acting in conjunction by phosphatidylserine, ginkgo biloba p.e, linseed oil and vitamin E etc. reaches and improves memory, the technique effect that product stability is good.
The specific embodiment
Below in conjunction with embodiment, describe the present invention in detail.
Embodiment 1
Improve the memory composition what present embodiment provided a kind of good stability, composed of the following components: phosphatidylserine 125g, ginkgo biloba p.e 95g, vitaminB10 .9g, vitamin B6 0.9g, folic acid 0.13g, linseed oil 331.6g, beeswax 16.5g, vitamin E 0.45g;
Improve the memory capsule what present embodiment also provided a kind of good stability, comprise above-mentioned composition and capsule skin, the capsule skin is composed of the following components: gelatin 221g, glycerine 90.5g, burnt sugar coloring 3.65g, titanium dioxide 0.5g, purified water 206.7g;
Also provide the preparation method who improves the memory capsule of good stability at present embodiment, may further comprise the steps:
S1. glue capsule skin:
A. with glycerine 90.5g, purified water 206.7g, gelatin 221g inputization glue tank, be heated to 75 ℃ of colloidal sols, get sol solutions;
B. again titanium dioxide 0.5g, burnt sugar coloring 3.65g are dropped into sol solutions and stir, constant temperature stirred 45 minutes, got the glue mixed material;
C. the glue mixed material is vacuumized, more than control vacuum-0.06Mpa, close vacuum, open air bleeding valve, detect the glue viscosity at 2.8 ten thousand mPa s;
D. glue is crossed 90 order filter bags, 58 ℃ of insulations of glue, for subsequent use;
S2. composition processed: get linseed oil 331.6g, beeswax 16.5g, vitaminB10 .9g, vitamin B6 0.9g, natural VE 0.45g, folic acid 0.13g, phosphatidylserine 125g, ginkgo biloba p.e 95g drop in the material-compound tank, stirred 22 minutes, get the composition total mixture, grind and filter, for subsequent use;
S3. pelleting: composition, glue are pressed into soft capsule in rolling the pattern encapsulating machine, composition dosage is the 600mg/ grain;
S4. typing: 21 ℃ of control temperature, finalized the design 3.5 hours by relative humidity 28% at environment for the soft capsule that presses;
S5. dry: with stereotyped capsule 21 ℃ of temperature, aeration-drying under relative humidity 25% condition.
Taking dose: 1 of every day, namely every day 0.6g.
Embodiment 2
Improve the memory composition what present embodiment provided a kind of good stability, composed of the following components: phosphatidylserine 130g, ginkgo biloba p.e 100g, VB11 .0g, vitamin B6 1.0g, folic acid 0.15g, linseed oil 349.05g, beeswax 18.3g, vitamin E 0.5g;
Improve the memory capsule what present embodiment also provided good stability, comprise above-mentioned composition and capsule skin, the capsule skin is composed of the following components: gelatin 232.5g, glycerine 95.32g, burnt sugar coloring 4.05g, titanium dioxide 0.55g, purified water 217.6g;
The preparation method who improves the memory capsule of the good stability of present embodiment is with to take dosage identical with embodiment 1.
Embodiment 3
Improve the memory composition what present embodiment provided a kind of good stability, composed of the following components: phosphatidylserine 135g, ginkgo biloba p.e 105g, VB11 .1g, vitamin B6 1.1g, folic acid 0.17g, linseed oil 366.5g, beeswax 20.1g, vitamin E 0.55g;
Improve the memory capsule what present embodiment also provided a kind of good stability, comprise above-mentioned composition and capsule skin, the capsule skin is composed of the following components: gelatin 244g, glycerine 100g, burnt sugar coloring 4.45g, titanium dioxide 0.6g, purified water 228.5g;
The preparation method who improves the memory capsule of the good stability of present embodiment is with to take dosage identical with embodiment 1.
Embodiment 4
Stability test
(1) Interventions Requested: sensory test
The capsule that sample specification and quantity: embodiment 2 makes, 600mg/ grain * 60/bottle, 100 bottles/batches
Assay: sample is soft capsule, and content is brown dope, has the distinctive flavour of this product and smell, and free from extraneous odour is without the visible impurity of naked eyes.The preliminary investigation thinks that it is compatible that sample property meets material.
(2) Interventions Requested: net content, minus deviation
The capsule that sample specification and quantity: embodiment 2 makes, 600mg/ grain * 60/bottle, 7 bottles/batches
Batch number: 20111201,20111202,20111203
Assay:
(3) Interventions Requested: alpha-linolenic acid
The capsule that sample specification and quantity: embodiment 2 makes, 600mg/ grain * 60/bottle, 7 bottles/batches
Batch number: 20111201,20111202,20111203
Assay:
Sample is placed condition: temperature 37-40 ℃, relative humidity 75%
Conclusion 1: as can be seen from the above table, alpha-linolenic acid is at temperature 37-40 ℃ in the product, and under relative humidity 75% condition, content is slow.Explanation is under hot and humid condition, and linseed oil mixes compatibility with unclassified stores in the composition better, and the storeroom compatibility stability is higher
(4) Interventions Requested: phosphatidylserine, Total Ginkgo Flavone-Glycoides
The capsule that sample specification: embodiment 2 makes, 600mg/ grain * 60/bottle
Batch number: 20111201,20111202,20111203
Assay:
Stability test: acceleration environment is temperature 37-40 ℃, relative humidity 75%
Conclusion 2: as can be seen from the above table, phosphatidylserine and Total Ginkgo Flavone-Glycoides are under hot and humid condition, and content is slow.Explanation is under hot and humid condition, and phosphatidylserine and ginkgo biloba extract mix compatibility with unclassified stores in the composition better, and the storeroom compatibility stability is higher.
(5) Interventions Requested: folic acid, vitamin B6, alpha-linolenic acid, mercury, total arsenic, lead, disintegration time limited, acid value, peroxide value, ash content, aflatoxins poison B1, vitamin B1
The capsule that sample specification and quantity: embodiment 2 makes, 600mg/ grain * 60/bottle, 7 bottles/batches
Batch number: 20111201,20111202,20111203
Assay:
Sample is placed condition: temperature 37-40 ℃, relative humidity 75%
Conclusion 3: as can be seen from the above table, folic acid, vitamin B1, vitamin B6 and alpha-linolenic acid are under hot and humid condition, and content is slow.Illustrate between folic acid, vitamin B1, vitamin B6 and the linseed oil and with composition in to mix compatibility between the unclassified stores better, the storeroom compatibility stability is higher
In addition, under hot and humid condition, its related substances all meets standard; Do not change disintegration time limited; Acid value, peroxide value vary stable, storage-stable is high.
(6) Interventions Requested: total plate count, Escherichia coli, Molds and yeasts counting, salmonella, Shigella, hemolytic streptococcus, staphylococcus aureus.
The capsule that sample specification and quantity: embodiment 2 makes, 600mg/ grain * 60/bottle, 3 bottles/batches
Batch number: 20111201,20111202,20111203
Assay:
Conclusion 4: as can be seen from the above table, in embodiment 2 compositions between each material compatibility use and to meet microbial standard.
Can find out that from the above-mentioned data that respectively detect each component compatibility of embodiment 2 compositions uses, the storeroom compatibility is better.The capsule that improves memory that prescription makes according to the present invention has stronger stability.
Embodiment 5
Improve the functional check of memory
1. the capsule that makes of sample: embodiment 2, taking dose is one of every day, namely every day 0.6g.
2. study subject: the experimenter did not accept similar test, did not take in a short time the article relevant with improving the memory function, considered as far as possible the factors such as educational level, age, carried out the harmony test.Take the given the test agent front and back and all the experimenter is carried out the test of a memory quotient.The experimenter is divided into three groups, young group 20 people, age 16-25 year, middle age group 20 people, age 26-45 year, old group 20 people, age 46-65 year.
3. test-meal method: capsule that embodiment 2 makes for each person every day, took continuously 30 days.
4. result:
Try the trencherman in inspections such as edible this product front and back ordinary circumstances, the health no abnormality seen, surperficial test-meal this product has no adverse effects.
Young group examination trencherman levies generally notice and concentrates, it is quicker that thinking becomes, brain is not easy fatigue, the examination anxiety mood reduces, achievement generally improves, and the result shows before and after the test-meal: the vision after the examination trencherman test-meal is re-recognized, associative learning, understandability, touch test, divide meter to divide all to be higher than test-meal along the back of the body, fall-back before.Wherein, fall-back divides meter to divide after the test-meal than on average having improved 20% before the test-meal.
The examination trencherman's of middle age group sleep quality generally has the positive effect of improving, life is emotionally stable, improve forgetful symptom, the result shows before and after the test-meal: the vision after the examination trencherman test-meal is re-recognized, associative learning, understandability, touch test, divide meter to divide all to be higher than test-meal along the back of the body, fall-back before.Wherein, fall-back divides meter to divide after the test-meal than on average having improved 8% before the test-meal.
The examination trencherman state of mind of old group is generally better than in the past, the health indices is all healthy, effectively prevent senile dementia, the result shows before and after the test-meal: the vision after the examination trencherman test-meal is re-recognized, associative learning, understandability, touch test, divide meter to divide all to be higher than test-meal along the back of the body, fall-back before.Wherein, fall-back divides meter to divide after the test-meal than on average having improved 2.2% before the test-meal.
The above is the preferred embodiments of the present invention only, is not limited to the present invention, and for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1.
A kind of memory composition that improves is characterized in that component comprises: ginkgo biloba p.e, phosphatidylserine, linseed oil.
2. the composition that improves memory according to claim 1 also comprises vitamin B1, vitamin B6, folic acid, beeswax and vitamin E.
3. the composition that improves memory according to claim 2, consisting of of each component: phosphatidylserine 125-135 part, ginkgo biloba p.e 95-105 part, vitaminB10 .9-1.1 part, vitamin B6 0.9-1.1 part, folic acid 0.13-0.17 part, linseed oil 331.6-366.5 part, beeswax 16.5-20.1 part, vitamin E 0.45-0.55 part.
4. the memory composition that improves according to claim 2, it is characterized in that, by weight composed of the following components: 130 parts of phosphatidylserines, 100 parts of ginkgo biloba p.es, VB11 .0 part, 1.0 parts of vitamin B6s, 0.15 part in folic acid, 349.05 parts of linseed oil, 18.3 parts in beeswax, 0.5 part of vitamin E.
5. one kind is improved the memory capsule, it is characterized in that, is comprised of claim 1 or 3 arbitrary compositions and capsule skin.
6. the memory capsule that improves according to claim 5 is characterized in that, described capsule skin is by weight composed of the following components: gelatin 221-244 part, glycerine 90.5-100 part, burnt sugar coloring 3.65-4.45 part, titanium dioxide 0.5-0.6 part, purified water 206.7-228.5 part.
7. the memory capsule that improves according to claim 6 is characterized in that, described capsule skin is by weight composed of the following components: 232.5 parts in gelatin, 95.32 parts of glycerine, 4.05 parts of burnt sugar colorings, 0.55 part of titanium dioxide, 217.6 parts of purified water.
8. preparation method who improves the memory capsule may further comprise the steps:
S1. glue capsule skin:
A. with glycerine 90.5-100 part, purified water 206.7-228.5 part, gelatin 221-244 part inputization glue tank, be heated to 70-80 ℃ of colloidal sol, get sol solutions;
B. again titanium dioxide 0.5-0.6 part, burnt sugar coloring 3.65-4.45 part are dropped into sol solutions and stirred, constant temperature stirred 40-50 minute, got the glue mixed material;
C. the glue mixed material is vacuumized, more than control vacuum-0.06Mpa, close vacuum, open air bleeding valve, detect the glue viscosity at 2.0 ten thousand-3.5 ten thousand mPas;
D. glue is crossed 80-100 order filter bag; Glue 50-65 ℃ insulation, for subsequent use;
S2. composition processed: get linseed oil 331.6-366.5 part, beeswax 16.5-20.1 part, vitaminB10 .9-1.1 part, vitamin B6 0.9-1.1 part, vitamin E 0.45-0.55 part, folic acid 0.13-0.17 part, phosphatidylserine 125-135 part, ginkgo biloba p.e 95-105 part and drop in the material-compound tank, stirred 15-30 minute, get the composition total mixture, grind and filter, for subsequent use;
S3. pelleting: composition, glue are pressed into soft capsule in rolling the pattern encapsulating machine;
S4. typing: 18-25 ℃ of control temperature, relative humidity 20-35%'s soft capsule that presses finalized the design 2-5 hour at environment; S5. dry: with stereotyped capsule at temperature 18-25 ℃, aeration-drying under the relative humidity 20-30% condition.
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| CN107997155A (en) * | 2017-12-01 | 2018-05-08 | 北京斯利安药业有限公司 | A kind of composition, its application and product that is anti-oxidant, improving memory |
| CN108077936A (en) * | 2017-11-16 | 2018-05-29 | 山西五台山沙棘制品有限公司 | A kind of Seabuckthorn Oil Spirulina soft capsule and preparation method thereof |
| CN108477622A (en) * | 2018-04-16 | 2018-09-04 | 赵成群 | A kind of infant's global function alimentation composition |
| CN109498643A (en) * | 2018-12-06 | 2019-03-22 | 北京斯利安药业有限公司 | A kind of folate composition and its application in the old mistake intelligence drug of preparation improvement |
| CN109938147A (en) * | 2019-03-29 | 2019-06-28 | 江西美好时光生物科技有限公司 | A kind of low sugar DHA gel candy improving memory and strengthen immunity |
| CN110051795A (en) * | 2019-05-29 | 2019-07-26 | 郑欣桐 | A kind of composition and preparation method thereof slowing down memory loss |
| CN110089580A (en) * | 2019-01-04 | 2019-08-06 | 江西维特健康咨询服务有限公司 | A kind of linseed oil |
| CN112075625A (en) * | 2020-09-11 | 2020-12-15 | 深圳太太药业有限公司 | Composition for improving memory, soft capsule thereof and preparation method thereof |
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| CN110089580A (en) * | 2019-01-04 | 2019-08-06 | 江西维特健康咨询服务有限公司 | A kind of linseed oil |
| CN109938147A (en) * | 2019-03-29 | 2019-06-28 | 江西美好时光生物科技有限公司 | A kind of low sugar DHA gel candy improving memory and strengthen immunity |
| CN110051795A (en) * | 2019-05-29 | 2019-07-26 | 郑欣桐 | A kind of composition and preparation method thereof slowing down memory loss |
| CN112075625A (en) * | 2020-09-11 | 2020-12-15 | 深圳太太药业有限公司 | Composition for improving memory, soft capsule thereof and preparation method thereof |
| CN112807333A (en) * | 2021-02-04 | 2021-05-18 | 江西建昌帮食疗科技有限公司 | Composition for enhancing memory and preparation method thereof |
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