CN104622843B - A kind of flexible glue encapsulated gluing method - Google Patents
A kind of flexible glue encapsulated gluing method Download PDFInfo
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- CN104622843B CN104622843B CN201510009159.4A CN201510009159A CN104622843B CN 104622843 B CN104622843 B CN 104622843B CN 201510009159 A CN201510009159 A CN 201510009159A CN 104622843 B CN104622843 B CN 104622843B
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Abstract
The present invention relates to drug field, the change gluing method of more particularly to a kind of soft capsule.This method makes the melting of gelatin more uniform by controlling the time of contact of gelatin and water, initially contacting temperature, firing rate, by using proof, and the present invention dissolves next glue, and rubber is highly stable in process of production, no influence quality influence.Contrasted by viscosity, the lower viscosity of same formula improves 15%；In terms of dissolving equivalent viscosities glue, gelatin accounts for 42% in being matched according to glue, can reduce by 6.3% gelatin input.
Description
Technical field
The present invention relates to drug field, more particularly to a kind of flexible glue encapsulated gluing method.
Background technology
Capsule shells are mainly used in medicine, pharmaceutical industry.Medical hollow capsule is mainly used in containing solid drugs, such as makes by oneself and dissipates
Agent, health products, medicament etc., capsule shells are that user solves difficult entrance, the weak point of poor taste, really solve good medicine not
The problem of bitter to the taste again.Capsule shells be with the medicinal gelatin of food grade by precision processing and auxiliary material be fabricated by for containing
The ovate hollow casing of solid powder, particle.Capsule shells have good bioavilability, can be rapid, reliably and securely molten
Solution.
Edible gelatin is widely used in numerous food product, such as pudding, sweet food, preserved fruit, chewing type candy, sugar-coat, food
Can and dip.In food, gelatin can help foodstuff solidification, retrogradation, stably, ventilation, be it is a kind of it is extremely welcome, be rich in
Nutrition and low-fat food ingredients.Edible gelatin is a kind of water soluble protein extracted from collagen in itself, and collagen
Matter is main native protein composition in connective tissue.Edible gelatin is by a controlled extraction process, from animal
Obtained in skin and bone.Edible gelatin has polytype.Capsule shells are made up of pharmaceutical grade gelatin, and the rank gelatin must be accorded with
Share the strict demand in drug products.
Collagen is dissolved in water and passs on process being referred to as glue for glue.It is one of key of capsule manufacture to change glue.
Traditional adhesive process flow, puts into formula ratio purified water, puts into formula ratio glycerine, agitating and heating about 55-60 minutes
72 DEG C -76 DEG C are reached Deng the temperature for changing glue tank, formula ratio gelatin agitating and heating about 90 minutes under negative pressure is put into, waits glue complete
Fine melt is melted, and (as change there is coloring agent to add the pigment that mixes up 2 minutes after) start to vacuumize until above glue in bubble-free,
About 15 minutes, stop stirring and take out 5-10 minutes vacuum again, turn off vacuum valve, to glue tank vacuum breaker is changed, be forced into 0.05pa and put glue,
Glue filters 200 mesh.Glue uses process：When have cotton shape ebonite, often influence whether rubber quality, will give birth to without notice
Output is largely deformed, an oil leak ball, adds many operational hidden danger of quality.
Therefore it provides a kind of new change adhesive process has important practical significance.
The content of the invention
In view of this, the present invention provides a kind of change gluing method of soft capsule.This method is by controlling contact of the gelatin with water
Time, initial contact temperature, firing rate, make the melting of gelatin more uniform, and by using proof, the present invention dissolves what is come
Rubber is highly stable in process of production for glue, no influence quality influence.Contrasted by viscosity, the lower viscosity of same formula is improved
15%, reduce Productive statistics.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides one kindization gluing method, raw material is made up of following component：
Describedization gluing method comprises the following steps：
Step 1：Fetch water after being mixed with glycerine, then mixed with gelatin, normal heating starts to vacuumize to 72 DEG C~76 DEG C,
Keep negative pressure -0.075MPa~15~20min of -0.08Mpa, termination is vacuumized, keep negative pressure -0.075MPa in tank~-
20~25min of 0.08Mpa stirring boilings；
Step 2：Glue made from step 1 is taken to drive vacuum valve, vacuum degree control is protected between -0.075MPa~-0.08Mpa
8~15min is held, stops stirring standing and vacuumizes 5~8min, obtain glue.
Normal pressure, refers to an atmospheric pressure, i.e., the gas pressure that this atmosphere that we live usually is produced.One standard is big
Air pressure is 101325Pa (handkerchief, Pascal-conventional pressure unit).100,000Pa=100KPa, so " standard atmospheric pressure "
We also commonly use 100KPa or 101KPa and represented.
Glue by the particle by this fusion processes of low temperature to high temperature, gelatin is melted after absorbing water from level to level, the present invention
By controlling the time of contact of gelatin and water, initially contacting temperature, firing rate, make the melting of gelatin more uniform, by making
With proof, the present invention dissolves next glue, and rubber is highly stable in process of production, no influence quality influence.
Contrasted by viscosity, the lower viscosity of same formula improves 15%, and the viscosity of glue is directly by temperature and time during reason
Influence, temperature is higher, and the time is longer, and its viscosity decline is faster, is contrasted from time and temperature, so the viscosity of glue
Increase.
In terms of dissolving equivalent viscosities glue, gelatin accounts for 42% in being matched according to glue, can reduce by 6.3% gelatin input.
Every batch of about 20kg × 55=1108 member.
In some specific embodiments of the present invention, vacuumize and vacuumized and standing is taken out including stirring described in step 2
Vacuum；The time that the stirring is vacuumized is 8~15min, and the time that the standing is vacuumized is 5~8min.
In some specific embodiments of the present invention, the time heated described in step 1 is 50~60min.
In some specific embodiments of the present invention, the programming rate heated described in step 1 is 0.7 DEG C/min~0.9
℃/min。
In some specific embodiments of the present invention, also include vacuum breaker, addition pigment after step 1 before step 2
The step of.
In some specific embodiments of the present invention, after water intaking is mixed with glycerine described in step 1, described and gelatin
The step of also including 1~2min of stirring before mixing.
In some specific embodiments of the present invention, after acquisition glue described in step 2, in addition to the step of filtering,
The sieve aperture of the filtering is 200 mesh.
The invention provides one kindization gluing method.This method comprises the following steps：
Step 1：Fetch water after being mixed with glycerine, then mixed with gelatin, normal heating starts to vacuumize to 72 DEG C~76 DEG C,
Keep negative pressure -0.075MPa~15~20min of -0.08Mpa, close vacuum valve, keep negative pressure -0.075MPa in tank~-
20~25min of 0.08Mpa stirring boilings；
Step 2：Glue made from step 1 is taken to drive vacuum valve, vacuum degree control is protected between -0.075MPa~-0.08Mpa
8~15min is held, stops stirring standing and vacuumizes 5~8min, obtain glue.
The present invention makes the melting of gelatin more uniform by controlling firing rate, and by using proof, the present invention is dissolved
Rubber is highly stable in process of production for the glue come, no influence quality influence.Contrasted by viscosity, the lower viscosity of same formula is carried
It is high by 15%；In terms of dissolving equivalent viscosities glue, gelatin accounts for 42% in being matched according to glue, can reduce by 6.3% gelatin input.Often
Criticizing about 20kg × 55=1108 members reduces Productive statistics.
Embodiment
The invention discloses one kindization gluing method, those skilled in the art can use for reference present disclosure, be suitably modified technique
Parameter is realized.In particular, all similar replacements and change be apparent for a person skilled in the art
, they are considered as being included in the present invention.The method of the present invention and application are described by preferred embodiment, phase
Pass personnel can substantially not depart from present invention, method described herein and application are being modified or fitted in spirit and scope
When change is with combining, to realize and apply the technology of the present invention.
Raw material can have market to buy in the change gluing method that the present invention is provided.Wherein, gelatin is bright purchased from Luo Sailuo (Guangdong)
Glue Co., Ltd；Glycerine is purchased from Hunan that Kang Zhi medicines limited company；Titanium dioxide has purchased from Germany's Sha Haliben chemistry
Limit company；
With reference to embodiment, the present invention is expanded on further：
Embodiment 1 changes gluing method
Rubber is formulated：
| Supplementary material title | Every (g) | 1000000 (kg) |
| Gelatin (bone glue, 150LB) | 0.2342 | 234.16 |
| Glycerine | 0.0950 | 94.96 |
| Titanium dioxide | 0.0097 | 9.70 |
| Purified water | 0.2190 | 219.03 |
Formula ratio purified water is put into, formula ratio glycerine is put into, stirring puts into gelatin, about 60 points of agitating and heating after 1-2 minutes
The temperature of the change glue tank such as clock reaches 74 DEG C, and (programming rate is 0.7 DEG C/min.), start to take out the true nothing above glue empty for the first time
Come on bubble (in vacuumizing 20min under -0.075 negative pressure).Turn off vacuum valve, termination is vacuumized, keep tank in negative pressure-
0.075MPa boiling 25min, (if changing has coloring agent, vacuum breaker added pigment after 2 minutes) opening vacuum valve carries out the 2nd time and taken out
Vacuum, vacuum degree control keeps 15min in -0.075MPa, and tank level steadily stops stirring afterwards, and standing vacuumizes 8min, i.e.,
Can completion glue process.Glue filters 200 mesh.
The wholeization gluing method time：60+20+25+15+8=128min.
Embodiment 2 changes gluing method
Rubber is formulated：
| Supplementary material title | Every (g) | 1000000 (kg) |
| Gelatin (bone glue, 150LB) | 0.2201 | 220.05 |
| Glycerine | 0.0950 | 94.96 |
| Titanium dioxide | 0.0097 | 9.70 |
| Purified water | 0.2328 | 232.80 |
Formula ratio purified water is put into, formula ratio glycerine is put into, stirring puts into gelatin, about 50 points of agitating and heating after 1-2 minutes
The temperature that clock etc. changes glue tank reaches 76 DEG C (programming rate is 0.9 DEG C/min), starts to take out the true nothing above glue empty for the first time
Come on bubble (in vacuumizing 15min under -0.08MPa negative pressure.Turn off vacuum valve, keep negative pressure in tank in -0.08MPa~
20min is vacuumized under negative pressure, (change has coloring agent, and vacuum breaker added pigment after 2 minutes) opening vacuum valve carries out the 2nd time and vacuumized,
Vacuum degree control keeps 8min in -0.08Mpa, and tank level steadily stops stirring afterwards, and standing vacuumizes 5min, you can completionization
Glue process.Glue filters 200 mesh.
The wholeization gluing method time：60+20+25+15+8=128min.
Embodiment 3 changes gluing method
Rubber is formulated：
| Supplementary material title | Every (g) | 1000000 (kg) |
| Gelatin (bone glue, 150LB) | 0.24 | 240.16 |
| Glycerine | 0.09 | 90.00 |
| Titanium dioxide | 0.009 | 9.00 |
| Purified water | 0.2400 | 240.03 |
Formula ratio purified water is put into, formula ratio glycerine is put into, stirring puts into gelatin, about 50 points of agitating and heating after 1-2 minutes
The temperature of the change glue tank such as clock reaches 76 DEG C, and (programming rate is 0.8 DEG C/min.), start to take out the true nothing above glue empty for the first time
Come on bubble (in vacuumizing 18min under -0.078MPa negative pressure).Turn off vacuum valve, termination is vacuumized, keep tank in negative pressure-
0.078MPa boiling 23min, (change has coloring agent, and vacuum breaker added pigment after 2 minutes) opening vacuum valve carries out the 2nd time and vacuumized,
Vacuum degree control keeps 12min in -0.078Mpa, and tank level steadily stops stirring afterwards, and standing vacuumizes 8min, you can complete
Change glue process.Glue filters 200 mesh.
The wholeization gluing method time：55+18+20+10+7=110min.
Embodiment 4 changes gluing method
Rubber is formulated：
| Supplementary material title | Every (g) | 1000000 (kg) |
| Gelatin (bone glue, 150LB) | 0.22 | 220.00 |
| Glycerine | 0.10 | 100.00 |
| Titanium dioxide | 0.100 | 10.00 |
| Purified water | 0.2100 | 210.00 |
Formula ratio purified water is put into, formula ratio glycerine is put into, stirring puts into gelatin, about 53 points of agitating and heating after 1-2 minutes
The temperature of the change glue tank such as clock reaches 75 DEG C, and (programming rate is 0.85 DEG C/min.), start to take out true empty above glue for the first time
Come in bubble-free (in vacuumizing 16min under -0.075MPa pressure).Turn off vacuum valve, keep negative pressure -0.075MPa in tank
22min, (change has coloring agent, and vacuum breaker added pigment after 2 minutes) opening vacuum valve carries out the 2nd time and vacuumized, vacuum degree control
12min is kept in -0.075MPa, tank level steadily stops stirring afterwards, and standing vacuumizes 6min, you can completionization glue process.
Glue filters 200 mesh.
The wholeization gluing method time：53+25+12+6=96min.
The quality testing of embodiment 5
Control group：
Traditional adhesive process flow, puts into formula ratio purified water, puts into formula ratio glycerine, agitating and heating about 55-60 minutes
72 DEG C -75 DEG C are reached Deng the temperature for changing glue tank, formula ratio gelatin agitating and heating about 90 minutes under negative pressure is put into, waits glue complete
Fine melt is melted, and (as change there is coloring agent to add the pigment that mixes up 2 minutes after) start to vacuumize until above glue in bubble-free,
About 15 minutes, stop stirring and take out 5-10 minutes vacuum again, turn off vacuum valve, to glue tank vacuum breaker is changed, be forced into 0.05pa and put glue,
Glue filters 200 mesh.
The wholeization gluing method time：60+90+15+10=175min.
Experimental group：Capsule skin made from embodiment 1.
Quality testing is carried out to obtained capsule skin, 1 is the results are shown in Table.
The capsule skin quality measurements of table 1
Glue by the particle by this fusion processes of low temperature to high temperature, gelatin is melted after absorbing water from level to level, control group
It is to immediately enter high-temperature digestion, experimental group is by controlling firing rate so that the melting of gelatin is more uniform, by using card
Bright, experimental group dissolves next glue, and rubber is highly stable in process of production, no influence quality influence.
Conclusion：Production process is more smooth after process modification, and product quality is also significantly improved.
Viscosity is contrasted：The lower viscosity of same formula improves 15%, reason：The viscosity of glue is directly influenceed by temperature and time,
Temperature is higher, and the time is longer, and its viscosity decline is faster, is contrasted from above-mentioned time and temperature, so the viscosity of glue has
Improved.
In terms of dissolving equivalent viscosities glue, gelatin accounts for 42% in being matched according to glue, can reduce by 6.3% gelatin input.
Every batch is about saved 20kg, and 20kg × 55=1108 members are calculated by every 55 yuan of kg gelatin；100000 batches can save 110,800,000, greatly
Save production cost
Above-mentioned experiment is carried out with capsule skin made from embodiment 2 to embodiment 4, the result of acquisition with made from embodiment 1
The quality measurements of capsule skin are close, no significant difference (P ＞ 0.05).
The gelatin viscosity that control group is dissolved is integrally relatively low, and glue uniformity is not good enough, can not be for a long time after machine on glue
Steady production, rubber has cotton shape ebonite.Compared with control group thing, the method viscosity that the present invention is provided integrally increases, and changes
Go out the glue of equivalent viscosities, gelatin input amount can reduce 6%, the former method of the glue mass ratio that equal insulation is used after standing is more
It is stable, had no adverse effects after upper machine, wholeization glue time lifting 30%.Do not change on raw material, simply process changes, and allows
Gelatin melts since low temperature, and one layer of ground melts, and melts more uniform, and the viscosity of glue is not again by temperature damage.Use new work
Skill, low gelatin input amount is that can reach appropriate viscosity, and cost is substantially reduced in big production.
The quality measurements of embodiment 6
Capsule skin made from embodiment 2.
Quality testing is carried out to obtained capsule skin, 2 are the results are shown in Table.
The capsule skin quality measurements of table 2
Conclusion：It is that can reach range of viscosities in the CP glue of 1.8-2.2 ten thousand with low input amount gelatin using present inventionization gluing method
Liquid, glue is uniform, is had no adverse effects after upper machine, and production is normal.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (5)
1. the change gluing method of a kind of soft capsule, it is characterised in that raw material is made up of following component：
Describedization gluing method comprises the following steps：
Step 1：Fetch water after being mixed with glycerine, then mixed with gelatin, normal heating starts to vacuumize to 72 DEG C~76 DEG C, keep
Negative pressure -0.075MPa~15~20min of -0.08Mpa, termination is vacuumized, and keeps negative pressure -0.075MPa~-0.08Mpa in tank
Stir 20~25min of boiling；
Step 2：Glue made from step 1 is taken to drive vacuum valve, vacuum degree control keeps 8 between -0.075MPa~-0.08Mpa
~15min, stops stirring standing and vacuumizes 5~8min, obtain glue；
The time heated described in step 1 is 50~60min, the programming rate of the heating for 0.7 DEG C/min~0.9 DEG C/
min。
2. according to claim 1ization gluing method, it is characterised in that vacuumize and vacuumized including stirring described in step 2
Vacuumized with standing；The time that the stirring is vacuumized is 8~15min, and the time that the standing is vacuumized is 5~8min.
3. according to claim 1ization gluing method, it is characterised in that also include before step 2 after step 1 vacuum breaker,
The step of adding pigment.
4. according to claim 1ization gluing method, it is characterised in that after water intaking is mixed with glycerine described in step 1, institute
State the step of also including 1~2min of stirring before being mixed with gelatin.
5. according to claim 1ization gluing method, it is characterised in that after acquisition glue described in step 2, in addition to filtering
The step of, the sieve aperture of the filtering is 200 mesh.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510009159.4A CN104622843B (en) | 2015-01-07 | 2015-01-07 | A kind of flexible glue encapsulated gluing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510009159.4A CN104622843B (en) | 2015-01-07 | 2015-01-07 | A kind of flexible glue encapsulated gluing method |
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| CN104622843A CN104622843A (en) | 2015-05-20 |
| CN104622843B true CN104622843B (en) | 2017-10-10 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108688001A (en) * | 2017-12-21 | 2018-10-23 | 济南汇川科技发展有限公司 | A kind of full-automation colloid system and method |
| CN108851063A (en) * | 2018-08-03 | 2018-11-23 | 汤臣倍健股份有限公司 | A kind of Co-Q10 natural vitamin E soft capsule and preparation method thereof |
| CN110876733A (en) * | 2019-12-06 | 2020-03-13 | 浙江仙琚医药科技有限公司 | Process for manufacturing soft capsule rubber |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662406B1 (en) * | 2009-08-06 | 2010-02-16 | Viva Pharmaceutical Inc. | Chewable softgel capsules |
| CN102218045A (en) * | 2011-06-14 | 2011-10-19 | 贵州地道药业有限公司 | New glue dissolving technology of soft capsules |
| CN103349291A (en) * | 2013-06-24 | 2013-10-16 | 汤臣倍健股份有限公司 | Composition and capsule with good stability and function of improving faculty of memory and preparation method thereof |
-
2015
- 2015-01-07 CN CN201510009159.4A patent/CN104622843B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662406B1 (en) * | 2009-08-06 | 2010-02-16 | Viva Pharmaceutical Inc. | Chewable softgel capsules |
| CN102218045A (en) * | 2011-06-14 | 2011-10-19 | 贵州地道药业有限公司 | New glue dissolving technology of soft capsules |
| CN103349291A (en) * | 2013-06-24 | 2013-10-16 | 汤臣倍健股份有限公司 | Composition and capsule with good stability and function of improving faculty of memory and preparation method thereof |
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