CN104489688A - 减轻化疗所致肝肾功能损伤副反应的保健药膳及制备 - Google Patents
减轻化疗所致肝肾功能损伤副反应的保健药膳及制备 Download PDFInfo
- Publication number
- CN104489688A CN104489688A CN201510008582.2A CN201510008582A CN104489688A CN 104489688 A CN104489688 A CN 104489688A CN 201510008582 A CN201510008582 A CN 201510008582A CN 104489688 A CN104489688 A CN 104489688A
- Authority
- CN
- China
- Prior art keywords
- parts
- chemotherapy
- hepatic
- renal function
- seed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002512 chemotherapy Methods 0.000 title claims abstract description 56
- 230000003908 liver function Effects 0.000 title claims abstract description 49
- 230000003907 kidney function Effects 0.000 title claims abstract description 44
- 230000006378 damage Effects 0.000 title claims abstract description 41
- 238000007086 side reaction Methods 0.000 title claims abstract description 34
- 235000013305 food Nutrition 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims description 26
- 239000003814 drug Substances 0.000 claims abstract description 40
- 235000015277 pork Nutrition 0.000 claims abstract description 35
- 244000077995 Coix lacryma jobi Species 0.000 claims abstract description 31
- 210000003056 antler Anatomy 0.000 claims abstract description 29
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 24
- 244000143590 Salvia chinensis Species 0.000 claims abstract description 23
- 235000007154 Salvia chinensis Nutrition 0.000 claims abstract description 23
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 22
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 22
- 229940079593 drug Drugs 0.000 claims abstract description 21
- 241001482311 Trionychidae Species 0.000 claims description 35
- 230000036541 health Effects 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 241000792914 Valeriana Species 0.000 claims description 28
- 235000017468 valeriana Nutrition 0.000 claims description 28
- 235000014676 Phragmites communis Nutrition 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 24
- 230000008569 process Effects 0.000 claims description 22
- 241000110637 Cuscuta chinensis Species 0.000 claims description 21
- 239000009636 Huang Qi Substances 0.000 claims description 21
- 241000218989 Trichosanthes Species 0.000 claims description 21
- 238000009835 boiling Methods 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 16
- 238000010791 quenching Methods 0.000 claims description 16
- 240000007594 Oryza sativa Species 0.000 claims description 14
- 235000007164 Oryza sativa Nutrition 0.000 claims description 14
- 238000010411 cooking Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 235000009566 rice Nutrition 0.000 claims description 14
- 235000019991 rice wine Nutrition 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- 235000021419 vinegar Nutrition 0.000 claims description 14
- 239000000052 vinegar Substances 0.000 claims description 14
- 235000014101 wine Nutrition 0.000 claims description 14
- 235000020097 white wine Nutrition 0.000 claims description 13
- 235000013372 meat Nutrition 0.000 claims description 9
- 239000003921 oil Substances 0.000 claims description 9
- 240000002234 Allium sativum Species 0.000 claims description 7
- 244000223014 Syzygium aromaticum Species 0.000 claims description 7
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 7
- 244000273928 Zingiber officinale Species 0.000 claims description 7
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 7
- 239000008157 edible vegetable oil Substances 0.000 claims description 7
- 235000011194 food seasoning agent Nutrition 0.000 claims description 7
- 239000003205 fragrance Substances 0.000 claims description 7
- 235000004611 garlic Nutrition 0.000 claims description 7
- 235000008397 ginger Nutrition 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 210000000936 intestine Anatomy 0.000 claims description 7
- 239000002304 perfume Substances 0.000 claims description 7
- 235000021110 pickles Nutrition 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 230000000171 quenching effect Effects 0.000 claims description 7
- 210000003734 kidney Anatomy 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 17
- 210000004185 liver Anatomy 0.000 abstract description 16
- 239000008280 blood Substances 0.000 abstract description 8
- 210000004369 blood Anatomy 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 235000006533 astragalus Nutrition 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 210000000582 semen Anatomy 0.000 abstract description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract description 2
- 241000736919 Pelodiscus sinensis Species 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract description 2
- 210000003899 penis Anatomy 0.000 abstract description 2
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241000347881 Kadua laxiflora Species 0.000 abstract 1
- 241000606265 Valeriana jatamansi Species 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 description 14
- 235000019634 flavors Nutrition 0.000 description 14
- 210000000952 spleen Anatomy 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 13
- 230000006870 function Effects 0.000 description 11
- 210000004072 lung Anatomy 0.000 description 11
- 239000000126 substance Substances 0.000 description 10
- 235000009508 confectionery Nutrition 0.000 description 9
- 206010062717 Increased upper airway secretion Diseases 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 208000026435 phlegm Diseases 0.000 description 8
- 230000007812 deficiency Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 238000005728 strengthening Methods 0.000 description 7
- 206010007247 Carbuncle Diseases 0.000 description 6
- MKMCJLMBVKHUMS-UHFFFAOYSA-N Coixol Chemical compound COC1=CC=C2NC(=O)OC2=C1 MKMCJLMBVKHUMS-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 230000003902 lesion Effects 0.000 description 6
- 231100000614 poison Toxicity 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 210000001367 artery Anatomy 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 206010046788 Uterine haemorrhage Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 239000002574 poison Substances 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 210000002105 tongue Anatomy 0.000 description 4
- 210000001835 viscera Anatomy 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000000973 chemotherapeutic effect Effects 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 208000006454 hepatitis Diseases 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 235000021374 legumes Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 229960003495 thiamine Drugs 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 2
- NGSWKAQJJWESNS-UHFFFAOYSA-N 4-coumaric acid Chemical compound OC(=O)C=CC1=CC=C(O)C=C1 NGSWKAQJJWESNS-UHFFFAOYSA-N 0.000 description 2
- 206010003011 Appendicitis Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241001061264 Astragalus Species 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 241000208365 Celastraceae Species 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010059013 Nocturnal emission Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 235000000336 Solanum dulcamara Nutrition 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 229930003451 Vitamin B1 Natural products 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 201000005630 leukorrhea Diseases 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- 201000000498 stomach carcinoma Diseases 0.000 description 2
- 210000003699 striated muscle Anatomy 0.000 description 2
- 210000004233 talus Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- 206010046901 vaginal discharge Diseases 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 235000010374 vitamin B1 Nutrition 0.000 description 2
- 239000011691 vitamin B1 Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- CUXYLFPMQMFGPL-BGDVVUGTSA-N (9Z,11E,13Z)-octadecatrienoic acid Chemical compound CCCC\C=C/C=C/C=C\CCCCCCCC(O)=O CUXYLFPMQMFGPL-BGDVVUGTSA-N 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- HRGUSFBJBOKSML-UHFFFAOYSA-N 3',5'-di-O-methyltricetin Chemical compound COC1=C(O)C(OC)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 HRGUSFBJBOKSML-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- NGSWKAQJJWESNS-ZZXKWVIFSA-M 4-Hydroxycinnamate Natural products OC1=CC=C(\C=C\C([O-])=O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-M 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- DFYRUELUNQRZTB-UHFFFAOYSA-N Acetovanillone Natural products COC1=CC(C(C)=O)=CC=C1O DFYRUELUNQRZTB-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 240000004510 Agastache rugosa Species 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 241000282985 Cervus Species 0.000 description 1
- 241000283007 Cervus nippon Species 0.000 description 1
- DPQCZNIGGNJGTD-UHFFFAOYSA-N Chloride-(??)-2-Methylpentanoic acid Natural products CCCCCCC=CCCCCCCCCCC(=O)OC(C)C(C)OC(=O)CCCCCCCC=CCCCCCC DPQCZNIGGNJGTD-UHFFFAOYSA-N 0.000 description 1
- 241000005787 Cistanche Species 0.000 description 1
- 241000209205 Coix Species 0.000 description 1
- 235000007354 Coix lacryma jobi Nutrition 0.000 description 1
- DPQCZNIGGNJGTD-MVCBGFDASA-N Coixenolide Chemical compound CCCCCC\C=C\CCCCCCCCCC(=O)O[C@@H](C)[C@@H](C)OC(=O)CCCCCCC\C=C/CCCCCC DPQCZNIGGNJGTD-MVCBGFDASA-N 0.000 description 1
- 206010009866 Cold sweat Diseases 0.000 description 1
- 241000207892 Convolvulus Species 0.000 description 1
- 235000014375 Curcuma Nutrition 0.000 description 1
- 244000164480 Curcuma aromatica Species 0.000 description 1
- 240000009138 Curcuma zedoaria Species 0.000 description 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- UYUXSRADSPPKRZ-SKNVOMKLSA-N D-glucurono-6,3-lactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 235000013717 Houttuynia Nutrition 0.000 description 1
- 240000000691 Houttuynia cordata Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 208000007466 Male Infertility Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028836 Neck pain Diseases 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 241000123069 Ocyurus chrysurus Species 0.000 description 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 240000002948 Ophiopogon intermedius Species 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 241000338512 Palea steindachneri Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- IDDMFNIRSJVBHE-UHFFFAOYSA-N Piscigenin Natural products COC1=C(O)C(OC)=CC(C=2C(C3=C(O)C=C(O)C=C3OC=2)=O)=C1 IDDMFNIRSJVBHE-UHFFFAOYSA-N 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 240000007332 Podocarpus macrophyllus Species 0.000 description 1
- 235000016408 Podocarpus macrophyllus Nutrition 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 244000223082 Syzygium paniculatum Species 0.000 description 1
- 235000016641 Syzygium paniculatum Nutrition 0.000 description 1
- 235000009065 Taxus cuspidata Nutrition 0.000 description 1
- 241001441726 Tetraodontiformes Species 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 244000078912 Trichosanthes cucumerina Species 0.000 description 1
- 241000975594 Trichosanthes rosthornii Species 0.000 description 1
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 241000792902 Valerianaceae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000009104 chemotherapy regimen Methods 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 description 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000915 fish venom Substances 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 229950002441 glucurolactone Drugs 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 231100000731 ichthyotoxin Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000005976 liver dysfunction Effects 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 150000003057 platinum Chemical class 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
- 229940032091 stigmasterol Drugs 0.000 description 1
- 235000016831 stigmasterol Nutrition 0.000 description 1
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- CUXYLFPMQMFGPL-UYWAGRGNSA-N trichosanic acid Natural products CCCCC=C/C=C/C=CCCCCCCCC(=O)O CUXYLFPMQMFGPL-UYWAGRGNSA-N 0.000 description 1
- BMCJATLPEJCACU-UHFFFAOYSA-N tricin Natural products COc1cc(OC)c(O)c(c1)C2=CC(=O)c3c(O)cc(O)cc3O2 BMCJATLPEJCACU-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 235000019509 white turmeric Nutrition 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- 229960003487 xylose Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明公开了一种减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份：黄芪10-20；芦根10-20；薏苡仁9-15；鹿茸5-10；石见穿9-12；蜘蛛香9-15；白花蛇舌草6-10；甘草10-15；狗鞭15-20；葛根10-16；菟丝子6-10；栝楼子6-10；鳖30-50；猪肚30-50。本发明的优良效果还表现在：本发明保健药膳采用天然的中药原料，其遵循中医的处方用药原则，经临床应用疗效显著可靠，药性平和，未出现毒副作用，应用前景广阔；本发明保健药膳具有补肝肾、益精血、助肾阳等优点；本发明保健药膳药源易得，药材成本低廉，能够减轻患者负担。
Description
技术领域
本发明涉及中医中药领域，特别是涉及一种减轻化疗所致肝肾功能损伤副反应的保健药膳及制备方法。
背景技术
癌症严重危害人类的健康。目前，化疗仍然为主要治疗手段，但其毒性易造成机体器官的损伤，常用的化疗药物如紫杉类化疗药物、长春瑞宾、鬼臼乙叉甙、铂类等均可引起肝脏和肾脏损害而影响治疗，严重时可导致肝肾功能衰竭。因此，寻找预防和治疗化疗所致肝肾损害的药物具有重要的临床意义。
化疗药物品种较多，一般兼具寒热夹杂的“毒”邪特性，其性深伏、峻烈，易耗伤正气，波及多脏腑。该“毒”不仅随着药物剂量的加大而增强，而且是之中脏腑、骨髓来产生毒害，损伤气血阴阳、四肢百骸，从而进一步引起脾胃脏腑功能的失调和肝肾功能的损伤，多造成血瘀表现。总的来说，化疗这种“毒”当属内毒之范畴。其致病特点表现为：1、怪异性：症状表现难以用一般的中医传统病因病机理论解释，临床症状间缺少内在的、常规的联系与规律性。2、凶险性：即指症候表现险恶、危重，易伤及生命；主要表现为势急病重，变化多端，危候迭出，或高热、或出血、或昏迷、或抽搐等。3、繁杂性：主要指临床症状表现过多，病变涉及多脏器、多系统；既有外周躯干症状，又有内资啊脏腑病变；既有卫气的症状，又有营血的病变；既有机体的疾病表现，又有精神情志的改变；病理属性既兼风火，又涉及痰淤；临床表现既有本虚标实，又有寒热错杂。
申请公布号 CN 101829307 A （申请号201010184872.X）的中国专利文献公开了一种治疗癌症化疗后消化道副作用的药物，它由以下药物制成：黄芪700-800g，麦冬250-350g，红参200-250g，白术200-250g，茯苓200-250g，甘草200-250g，玄参200-250g，当归200-250g，乌梅250-350g，法半夏250-350g，藿香200-250g，陈皮200-250g，莪术200-250g。申请公布号 CN 103263565 A（申请号 201310184360.7）的中国专利文献公开了一种治疗白血病以及减轻化疗副作用的中药制剂，由下述重量配比的原料制备而得：肉苁蓉200份、络石藤200份、鱼腥草100份、蚤休50份、白花蛇舌草15份、半枝莲15份、人参5份。申请公布号 CN 103960710 A（申请号201410102071.2）的中国发明者专利文献公开了一种减轻肿瘤患者化疗胃肠反应的保健汤及制备方法，主要取下述重量配比的原料制备而成：银耳4-10份，芦荟2-5份，人参叶1-4份，川楝子1.5-6 份，百合2-6份，郁李仁（炒）2-6份，炒枳壳3-7份。
目前使用葡醛内酯等预防对肝功能的损害，使用水化、碱化尿液，减少尿酸产生，促进尿酸排泄等措施防止对肾功能的损害。防护药物本身的副作用：针对单一症状，作用途径单一；新药价格昂贵，限制了临床使用；新药远期疗效尚不确切。等等均是西药减轻化疗毒副作用方面存在的问题。中医药物能够综合调节，邪正兼顾，在一定程度上制约化疗药物的毒性，减少病人的痛苦，使其抗病能力增强，保证化疗方案的实施。
发明内容
针对现有技术的不足，本发明的目的是提供一种制备简单、服用方便、安全有效的减轻化疗所致肝肾功能损伤副反应的保健药膳及制备方法。该药膳药性平和且疗效显著。
本发明的技术方案是：
减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份：黄芪10-20；芦根10-20；薏苡仁9-15；鹿茸5-10；石见穿9-12；蜘蛛香9-15；白花蛇舌草6-10；甘草10-15；狗鞭15-20；葛根10-16；菟丝子6-10；栝楼子6-10；鳖30-50；猪肚30-50。
优选的方案中，黄芪13-17；芦根14-16；薏苡仁11-13；鹿茸6-9；石见穿10-11；蜘蛛香11-13；白花蛇舌草7-9；甘草11-14；狗鞭16-19；葛根12-14；菟丝子7-9；栝楼子7-9；鳖35-45；猪肚35-45。
更加优选的，黄芪15；芦根15；薏苡仁12；鹿茸7.5；石见穿10.5；蜘蛛香12；白花蛇舌草8；甘草12.5；狗鞭17.5；葛根13；菟丝子8；栝楼子8；鳖40；猪肚40。
减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，步骤如下：
（1）蜘蛛香洗净，切片，置于白酒中浸泡，取出，晾干备用；取鹿茸片置文火上烘热，投入黄酒中淬，淬后再烘，至黄酒被吸尽，然后烧至灰黄色，边起小泡并有酥香味，晾凉，研成细粉，过筛，备用；薏苡仁置于粉碎机中，粉碎成细末，备用；
（2）将鳖置于沸水内煎煮，待甲上硬皮脱落，取出，剥下背甲及肠杂，备用；猪肚洗净，置于米醋和料酒中腌制15-35分钟（优选研制25分钟），然后取食盐搓洗猪肚，用清水冲洗干净，切段备用；
（3）将步骤（1）处理后的蜘蛛香与黄芪、石见穿、芦根、甘草、白花蛇舌草、葛根、菟丝子和栝楼子一同置于砂锅中，加清水浸泡1.5-2.5小时（优选加清水浸泡2小时），然后武火煮沸转文火煎煮两次，每次分别煎煮30-60分钟（优选每次分别煎煮45分钟），过滤，合并两次煎液，继续加热浓缩至原体积的1/2，停火，备用；
（4）向不粘锅中加入食用油，油热后加入蒜瓣、姜片炒香，然后加入狗鞭和步骤（2）中处理后的猪肚，炒至六成熟，加入步骤（1）处理过的鹿茸、薏苡仁以及步骤（2）处理后的鳖肉，小火炖煮2-5小时，停火前20-30分钟（优选停火前25分钟），加入步骤（3）所得煎液，加入食盐调味，即可。
上述减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，优选的方案是，步骤（1）中置于白酒中浸泡的时间为10-16小时（优选的置于白酒中浸泡的时间为12-14小时，更加优选的置于白酒中浸泡的时间为13小时）。
上述减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，优选的方案是，步骤（1）中过70-110目筛（优选的过80-100目筛，更加优选的过90目筛）。
上述减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，优选的方案是，步步骤（2）中鳖置于沸水内煎煮的时间为1-3小时（优选的鳖置于沸水内煎煮的时间为1.5-2.5小时，更加优选的鳖置于沸水内煎煮的时间为2小时）。
上述减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，优选的方案是，步骤（2）中米醋和料酒的体积比为3:1.2。
上述减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，优选的方案是，步骤（3）中所加清水的量为药材量的3.5-6.5倍（优选的所加清水的量为药材量的4-6倍，更加优选的所加清水的量为药材量的5倍）。
上述减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，优选的方案是，步骤（4）中小火炖煮3-4小时（优选的小火炖煮3.5小时）。
本发明组方科学，制备方法简单，服用方便、效果显著。除此之外，本发明的优良效果还表现在：
1、本发明保健药膳采用天然的中药原料，其遵循中医的处方用药原则，经临床应用疗效显著可靠，药性平和，未出现毒副作用，应用前景广阔。
2、本发明保健药膳具有补肝肾、益精血、助肾阳等优点。
3、本发明保健药膳药源易得，药材成本低廉，能够减轻患者负担。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案，但保护范围不限于此。
本发明所用主要中药原料的药理如下：
鹿茸：基原：为鹿科动物梅花鹿或马鹿的尚未骨化的幼角。性味：甘咸，温。归经：入肝、肾经。功能主治：壮元阳，补气血，益精髓，强筋骨。治虚劳羸瘦，精神倦乏，眩晕，耳聋，目暗，腰膝酸痛，阳痿，滑精；子宫虚冷，崩漏，带下。
薏苡仁：具有：为禾本科植物薏苡的种仁。化学成份：种仁含蛋白质16.2％，脂肪4.65％，碳水化物79.17％，少量维生素B1。种子含氨基酸（为亮氨酸、赖氨酸、精氨酸、酪氨酸等）、薏苡素、薏苡酯、三萜化合物。药理作用：①薏苡仁油的作用：用石油醚浸出的薏苡仁油对蛙的横纹肌及运动神经末梢，低浓度呈兴奋作用，高浓度呈麻痹作用。②薏苡素的作用：对横纹肌有抑制作用。性味：甘淡，凉。归经：入脾、肺、肾经。功能主治：健脾，补肺，清热，利湿。治泄泻，湿痹，筋脉拘挛，屈伸不利，水肿，脚气，肺痿，肺痈，肠痈，淋浊，白带。
芦根：基原：为禾本科植物芦苇的根茎。化学成份：芦根含薏苡素，以及蛋白质5％、脂肪1％、碳水化物51％、天门冬酰胺0.1％。芦苇含纤维素48～54％、木质素约18.2％、木聚糖约12.4％、灰分2.8％。多糖水解产生D-木糖、L-阿拉伯糖、D-葡萄糖、D-半乳糖和两种糖醛酸。另含多量维生素B1、B2和C，以及苜蓿素。性味：甘，寒。归经：入肺、胃经。功能主治：清热，生津，除烦，止呕。治热病烦渴，胃热呕吐，噎膈，反胃，肺痿，肺痈。并解河豚鱼毒。
石见穿：基原：为唇形科植物紫参的全草。化学成份：全草含甾醇、三萜成分、氨基酸。根含水苏糖。性味：《苏州本产药材》："苦辛，平。" 功能主治：治噎膈，痰喘，肝炎，赤白带，痈肿，瘰疬。
黄芪：基原：本品为豆科植物蒙古黄芪或膜荚黄芪的干燥根。性味：甘，温。归经： 归肺、脾经。功效：补气固表，利尿托毒，排脓，敛疮生肌。主治：用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
白花蛇舌草：基原：为茜草种植物白花蛇舌草的带根全草。化学成份：全草中分出卅一烷、豆甾醇、熊果酸、齐墩果酸，β-谷甾醇、β-谷甾醇-D-葡萄糖甙、对香豆酸等。药理作用：①抗肿瘤作用，②抗菌、消炎作用，性味：苦甘，寒。性味：苦甘，寒。功能主治：清热，利湿，解毒。治肺热喘咳，扁桃体炎。咽喉炎，阑尾炎，痢疾，尿路感染，黄疸，肝炎，盆腔炎，附件炎，痈肿疔疮，毒蛇咬伤，肿瘤。亦可用于消化道癌症。
甘草：基原：本品为豆科植物甘草、胀果甘草或光果甘草的干燥报及根茎。性味：甘，平。归经：归心。肺、脾、胃经。功效：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。主治：用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，院腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
狗鞭：基原：为犬科犬属动物雄性狗带睾丸的阴茎。化学成分：含雄性激素、蛋白质、脂肪等。性味：味咸，性温。归经：归肾经。具有温肾壮阳，补益精髓的功效；主治阳痿，遗精，男子不育，阴囊湿冷，腰膝酸软，形体羸弱，女子虚寒带下，产后体虚。
葛根：基原：本品为豆科植物野葛的干燥根。性状：本品呈纵切的长方形厚片或小方块。外皮淡棕色，有纵皱纹，粗糙。切面黄白色，纹理不明显。质韧，纤维性强。性味：甘、辛，凉。归经：归脾、胃经。功效：解肌退热，生津，透疹，升阳止泻。主治：用于外感发热头痛、项背强痛，口渴，消渴，麻疹不透，热痢，泄泻；高血压颈项强痛。
菟丝子：来源：本品为旋花科植物菟丝子的干燥成熟种子。性味：甘，温。归经：归肝、肾、脾经。功能主治：滋补肝肾，固精缩尿，安胎，明目，止泻。用于阳痿遗精，尿有余沥，遗尿尿频，腰膝酸软，目昏耳鸣，肾虚胎漏，胎动不安，脾肾虚泻；外治白癜风。
栝楼子：基原：为葫芦科植物栝楼或双边栝楼、大子栝楼等的种子。化学成份：栝楼仁含甙、皂甙、有机酸及其盐类（如草酸钙）、树胶、树脂、脂肪油及色素等。脂肪油含率约为26％，其中饱和脂肪酸占30％，不饱和者约占66.5％；不饱和脂肪酸以栝楼酸为主。性味：甘，寒。归经：入肺、胃、大肠经。功能主治：润肺，化痰，滑肠。治痰热咳嗽，燥结便秘，痈肿，乳少。
鳖（取鳖肉食用）：基原：为鳖科动物中华鳖或山瑞鳖的肉。化学成份：食部100g含水分80g，蛋白质16.5g，脂肪1.Og，碳水化物1.6g，灰分0.9g；钙107mg，磷135mg，铁1.4mg，硫胺素0.62mg，核黄素0.37mg，尼克酸3.7mg。性味：味甘；性平。归经：肝；肾经。功能主治：滋阴补肾；清退虚热。主虚劳赢瘦；骨蒸痨热；久疟；久痢；崩漏；带下；症 瘕；瘰疬。
猪肚：基原：为猪科动物猪的胃。性味：甘，温。功能主治：补虚损，健脾胃。治虚劳羸弱，泄泻，下痢，消渴，小便频数，小儿疳积。
蜘蛛香：为败酱科属植物蜘蛛香的根茎。成分：根和根茎主要含挥发性成分，还含有咖啡酸。药理：对中枢神经具有抑制作用，有抗肿瘤的作用。药性：辛，微苦，温。功能主治：理气和中，散寒除湿，活血消肿。
实施例1 减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份（50g/份）：黄芪10份；芦根10份；薏苡仁9份；鹿茸5份；石见穿9份；蜘蛛香9份；白花蛇舌草6份；甘草10份；狗鞭15份；葛根10份；菟丝子6份；栝楼子6份；鳖30份；猪肚30份。
减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法是：
（1）蜘蛛香洗净，切片，置于白酒中浸泡10小时，取出，晾干备用；取鹿茸片置文火上烘热，投入黄酒中淬，淬后再烘，至黄酒被吸尽，然后烧至灰黄色，边起小泡并有酥香味，晾凉，研成细粉，过70目筛，备用；薏苡仁置于粉碎机中，粉碎成细末，备用；
（2）将鳖置于沸水内煎煮1小时，待甲上硬皮脱落，取出，剥下背甲及肠杂，备用；猪肚洗净，置于米醋和料酒（米醋和料酒的体积比为3:1.2）中腌制15分钟，然后取食盐搓洗猪肚，用清水冲洗干净，切段备用；
（3）将步骤（1）处理后的蜘蛛香与黄芪、石见穿、芦根、甘草、白花蛇舌草、葛根、菟丝子和栝楼子一同置于砂锅中，加3.5倍药材量的清水浸泡1.5小时，然后武火煮沸转文火煎煮两次，每次分别煎煮30分钟，过滤，合并两次煎液，继续加热浓缩至原体积的1/2，停火，备用；
（4）向不粘锅中加入食用油，油热后加入蒜瓣、姜片炒香，然后加入狗鞭和步骤（2）中处理后的猪肚，炒至六成熟，加入步骤（1）处理过的鹿茸、薏苡仁以及步骤（2）处理后的鳖肉，小火炖煮2小时，停火前20分钟，加入步骤（3）所得煎液，加入食盐调味，即可。
本发明保健药膳的服用方法是：每天两次，每次200-300mL，温热服用，5天一疗程。
实施例2 减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份（30g/份）：黄芪20份；芦根20份；薏苡仁15份；鹿茸10份；石见穿12份；蜘蛛香15份；白花蛇舌草10份；甘草15份；狗鞭20份；葛根16份；菟丝子10份；栝楼子10份；鳖50份；猪肚50份。
减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法是：
（1）蜘蛛香洗净，切片，置于白酒中浸泡16小时，取出，晾干备用；取鹿茸片置文火上烘热，投入黄酒中淬，淬后再烘，至黄酒被吸尽，然后烧至灰黄色，边起小泡并有酥香味，晾凉，研成细粉，过110目筛，备用；薏苡仁置于粉碎机中，粉碎成细末，备用；
（2）将鳖置于沸水内煎煮3小时，待甲上硬皮脱落，取出，剥下背甲及肠杂，备用；猪肚洗净，置于米醋和料酒（米醋和料酒的体积比为3:1.2）中腌制35分钟，然后取食盐搓洗猪肚，用清水冲洗干净，切段备用；
（3）将步骤（1）处理后的蜘蛛香与黄芪、石见穿、芦根、甘草、白花蛇舌草、葛根、菟丝子和栝楼子一同置于砂锅中，加6.5倍药材量的清水浸泡2.5小时，然后武火煮沸转文火煎煮两次，每次分别煎煮60分钟，过滤，合并两次煎液，继续加热浓缩至原体积的1/2，停火，备用；
（4）向不粘锅中加入食用油，油热后加入蒜瓣、姜片炒香，然后加入狗鞭和步骤（2）中处理后的猪肚，炒至六成熟，加入步骤（1）处理过的鹿茸、薏苡仁以及步骤（2）处理后的鳖肉，小火炖煮5小时，停火前30分钟，加入步骤（3）所得煎液，加入食盐调味，即可。
本发明保健药膳的服用方法是：每天两次，每次200-300mL，温热服用，5天一疗程。
典型病例：王XX，男，54岁，邢台人。患者自述：2010年10月13日因胃癌进行手术治疗。11月22日开始进行化疗。化疗前肝功能正常。化疗过程中出现乏力腹胀、食欲不振、恶心，体重下降等现象。12月15日化验肝功能结果：S-GPT159单位，TTT10.4单位，TFT+ + +。中医检查：脉细，舌苔淡薄白。诊断为化疗所致肝功能损伤。
服用本实施例所得保健药膳，服用方法：每天两次，每次200-300mL，温热服用，5天一疗程。两个疗程后症状大部分减轻，肝功能明显改善，继续服用两个疗程，化验肝功能恢复正常，体重增加。半年后随访，肝功能未见异常，患者已停用化疗药以中药做康复巩固化疗。
实施例3 减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份（45g/份）：黄芪13份；芦根14份；薏苡仁11份；鹿茸6份；石见穿10份；蜘蛛香11份；白花蛇舌草7份；甘草11份；狗鞭16份；葛根12份；菟丝子7份；栝楼子7份；鳖35份；猪肚35份。
减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法是：
（1）蜘蛛香洗净，切片，置于白酒中浸泡12小时，取出，晾干备用；取鹿茸片置文火上烘热，投入黄酒中淬，淬后再烘，至黄酒被吸尽，然后烧至灰黄色，边起小泡并有酥香味，晾凉，研成细粉，过80目筛，备用；薏苡仁置于粉碎机中，粉碎成细末，备用；
（2）将鳖置于沸水内煎煮1.5小时，待甲上硬皮脱落，取出，剥下背甲及肠杂，备用；猪肚洗净，置于米醋和料酒（米醋和料酒的体积比为3:1.2）中腌制20分钟，然后取食盐搓洗猪肚，用清水冲洗干净，切段备用；
（3）将步骤（1）处理后的蜘蛛香与黄芪、石见穿、芦根、甘草、白花蛇舌草、葛根、菟丝子和栝楼子一同置于砂锅中，加4倍药材量的清水浸泡1.8小时，然后武火煮沸转文火煎煮两次，每次分别煎煮40分钟，过滤，合并两次煎液，继续加热浓缩至原体积的1/2，停火，备用；
（4）向不粘锅中加入食用油，油热后加入蒜瓣、姜片炒香，然后加入狗鞭和步骤（2）中处理后的猪肚，炒至六成熟，加入步骤（1）处理过的鹿茸、薏苡仁以及步骤（2）处理后的鳖肉，小火炖煮3小时，停火前22分钟，加入步骤（3）所得煎液，加入食盐调味，即可。
本发明保健药膳的服用方法是：每天两次，每次200-300mL，温热服用，5天一疗程。
实施例4 减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份（35g/份）：黄芪17份；芦根16份；薏苡仁13份；鹿茸9份；石见穿11份；蜘蛛香13份；白花蛇舌草9份；甘草14份；狗鞭19份；葛根12-14份；菟丝子9份；栝楼子9份；鳖45份；猪肚45份。
减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法是：
（1）蜘蛛香洗净，切片，置于白酒中浸泡14小时，取出，晾干备用；取鹿茸片置文火上烘热，投入黄酒中淬，淬后再烘，至黄酒被吸尽，然后烧至灰黄色，边起小泡并有酥香味，晾凉，研成细粉，过100目筛，备用；薏苡仁置于粉碎机中，粉碎成细末，备用；
（2）将鳖置于沸水内煎煮2.5小时，待甲上硬皮脱落，取出，剥下背甲及肠杂，备用；猪肚洗净，置于米醋和料酒（米醋和料酒的体积比为3:1.2）中腌制30分钟，然后取食盐搓洗猪肚，用清水冲洗干净，切段备用；
（3）将步骤（1）处理后的蜘蛛香与黄芪、石见穿、芦根、甘草、白花蛇舌草、葛根、菟丝子和栝楼子一同置于砂锅中，加6倍药材量的清水浸泡2.2小时，然后武火煮沸转文火煎煮两次，每次分别煎煮50分钟，过滤，合并两次煎液，继续加热浓缩至原体积的1/2，停火，备用；
（4）向不粘锅中加入食用油，油热后加入蒜瓣、姜片炒香，然后加入狗鞭和步骤（2）中处理后的猪肚，炒至六成熟，加入步骤（1）处理过的鹿茸、薏苡仁以及步骤（2）处理后的鳖肉，小火炖煮4小时，停火前28分钟8，加入步骤（3）所得煎液，加入食盐调味，即可。
本发明保健药膳的服用方法是：每天两次，每次200-300mL，温热服用，5天一疗程。
典型病例：刘XX，女，46岁， 2011年5月12日，患者因卵巢癌进行化疗。病检结果：卵巢恶性肿瘤，以移行细胞可能性大，术后给予5-氟尿嘧啶500ug腹腔内注射，化疗前心非正常，腹软，肝脾胁下未触及。化疗三次后，患者出现食欲欠佳，口干，右胁下不适，舌苔淡黄，脉细略弦。
服用本实施例所得，服用方法：每天两次，每次200-300mL，温热服用，5天一疗程。治疗两个疗程后，患者肝肾功能明显好转，其他症状减轻，继续服用两个疗程后，患者肝肾功能检查正常，患者顺利完成化疗出院。
实施例5 减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份（40g/份）：黄芪15份；芦根15份；薏苡仁12份；鹿茸7.5份；石见穿10.5份；蜘蛛香12份；白花蛇舌草8份；甘草12.5份；狗鞭17.5份；葛根13份；菟丝子8份；栝楼子8份；鳖40份；猪肚40份。
减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法是：
（1）蜘蛛香洗净，切片，置于白酒中浸泡13小时，取出，晾干备用；取鹿茸片置文火上烘热，投入黄酒中淬，淬后再烘，至黄酒被吸尽，然后烧至灰黄色，边起小泡并有酥香味，晾凉，研成细粉，过90目筛，备用；薏苡仁置于粉碎机中，粉碎成细末，备用；
（2）将鳖置于沸水内煎煮2小时，待甲上硬皮脱落，取出，剥下背甲及肠杂，备用；猪肚洗净，置于米醋和料酒（米醋和料酒的体积比为3:1.2）中腌制25分钟，然后取食盐搓洗猪肚，用清水冲洗干净，切段备用；
（3）将步骤（1）处理后的蜘蛛香与黄芪、石见穿、芦根、甘草、白花蛇舌草、葛根、菟丝子和栝楼子一同置于砂锅中，加5倍药材量的清水浸泡2小时，然后武火煮沸转文火煎煮两次，每次分别煎煮45分钟，过滤，合并两次煎液，继续加热浓缩至原体积的1/2，停火，备用；
（4）向不粘锅中加入食用油，油热后加入蒜瓣、姜片炒香，然后加入狗鞭和步骤（2）中处理后的猪肚，炒至六成熟，加入步骤（1）处理过的鹿茸、薏苡仁以及步骤（2）处理后的鳖肉，小火炖煮3.5小时，停火前25分钟，加入步骤（3）所得煎液，加入食盐调味，即可。
本发明保健药膳的服用方法是：每天两次，每次200-300mL，温热服用，5天一疗程。
试验例1 本发明所得减轻化疗所致肝肾功能损伤副反应的保健药膳（实施例5）的临床应用：
1、资料和方法
1.1 一般资料
2010年3月-2012年9月，在5所医院接受正规化疗治疗恶性肿瘤患者共215例，其中包括食道癌59例，乳房癌42例，肺癌48例，胃癌66例。其中女性95例，男性120例，年龄范围在33-69岁，平均年龄52.5岁。
1.2 筛选标准
所有患者至少接受1个周期化疗，化疗前肝肾功能正常。第1周期化疗后诊断为药物性肝肾损伤患者。所有病例均符合我国药物性肝肾损伤诊治共识意见中化疗药物所致肝肾损伤诊断标准。
1.3 治疗方法
所有患者随机分为对照组和治疗组。治疗组在第2周期化疗同时服用本发明所得产品，服用方法为：每天两次，每次200-300mL，温热服用。对照组在第2周期化疗同时服用其他防止肝肾损伤的药物（如益肝灵软胶囊、六味五灵片、甘利欣等常规药物）。共观察治疗三个周期。两组患者在性别、年龄、病情等因素上的差异性没有统计学意义（P>0.05），因此，具有可比性。
1.4 疗效评定标准
治愈：不适症状消失，脉、舌症状恢复正常，肝肾功能检查连续3次正常者；显效：不适症状基本消失，脉、舌症状基本恢复正常，肝肾功能检查连续2次正常，或治疗一个疗程以上肝肾功能开始恢复正常者；有效：主要症状消失或基本消失，肝肾功能检查原异常值下降50%以上者；无效：症状无改善，或虽有改善而肝肾功能无好转。
总有效率=（治愈例数+ 显效例数+ 有效例数）∕总观察病例数×100%。
1.5 治疗结果
治疗结果如表1所示：
表1：服用本发明产品33-69岁化疗所致肝肾损伤患者治疗结果
治疗效果：治愈63例（54.8%）， 显效30例（26.1%），有效19例（16.5%）；无效3例（2.6%），总有效率97.4%。效果明显优于对照组。
本发明黄芪、芦根、薏苡仁、鹿茸、石见穿、蜘蛛香、白花蛇舌草、甘草、狗鞭、葛根、菟丝子、栝楼子、鳖和猪肚进行组合。方中鹿茸具有壮元阳，补气血，益精髓，强筋骨的作用；薏苡仁健脾，补肺，清热，利湿；芦根清热，生津，除烦，止呕；石见穿治噎膈，痰喘，肝炎；白花蛇舌草具有清热，利湿，解毒的功效；狗鞭具有温肾壮阳，补益精髓的功效；菟丝子滋补肝肾，固精缩尿；栝楼子润肺，化痰，滑肠；甘草 补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药；全方配伍，共奏滋养肝阴、清利湿热、疏肝利胆，补肾利尿之功，对化疗所致肝肾损伤疗效显著。治疗组有效率可达97.4%，而对照组仅为74%。
应当指出的是，具体实施方式只是本发明比较有代表性的例子，显然本发明的技术方案不限于上述实施例，还可以有很多变形。本领域的普通技术人员，以本发明所明确公开的或根据文件的书面描述毫无异议的得到的，均应认为是本专利所要保护的范围。
Claims (10)
1.减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份：黄芪10-20；芦根10-20；薏苡仁9-15；鹿茸5-10；石见穿9-12；蜘蛛香9-15；白花蛇舌草6-10；甘草10-15；狗鞭15-20；葛根10-16；菟丝子6-10；栝楼子6-10；鳖30-50；猪肚30-50。
2.如权利要求1所述的减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份：黄芪13-17；芦根14-16；薏苡仁11-13；鹿茸6-9；石见穿10-11；蜘蛛香11-13；白花蛇舌草7-9；甘草11-14；狗鞭16-19；葛根12-14；菟丝子7-9；栝楼子7-9；鳖35-45；猪肚35-45。
3.如权利要求1所述的减轻化疗所致肝肾功能损伤副反应的保健药膳，其特征在于，由下列原料药制备而成，均为重量份：黄芪15；芦根15；薏苡仁12；鹿茸7.5；石见穿10.5；蜘蛛香12；白花蛇舌草8；甘草12.5；狗鞭17.5；葛根13；菟丝子8；栝楼子8；鳖40；猪肚40。
4.如权利要求1-3任一所述的减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，其特征是，步骤如下：
（1）蜘蛛香洗净，切片，置于白酒中浸泡，取出，晾干备用；取鹿茸片置文火上烘热，投入黄酒中淬，淬后再烘，至黄酒被吸尽，然后烧至灰黄色，边起小泡并有酥香味，晾凉，研成细粉，过筛，备用；薏苡仁置于粉碎机中，粉碎成细末，备用；
（2）将鳖置于沸水内煎煮，待甲上硬皮脱落，取出，剥下背甲及肠杂，备用；猪肚洗净，置于米醋和料酒中腌制15-35分钟（优选研制25分钟），然后取食盐搓洗猪肚，用清水冲洗干净，切段备用；
（3）将步骤（1）处理后的蜘蛛香与黄芪、石见穿、芦根、甘草、白花蛇舌草、葛根、菟丝子和栝楼子一同置于砂锅中，加清水浸泡1.5-2.5小时（优选加清水浸泡2小时），然后武火煮沸转文火煎煮两次，每次分别煎煮30-60分钟（优选每次分别煎煮45分钟），过滤，合并两次煎液，继续加热浓缩至原体积的1/2，停火，备用；
（4）向不粘锅中加入食用油，油热后加入蒜瓣、姜片炒香，然后加入狗鞭和步骤（2）中处理后的猪肚，炒至六成熟，加入步骤（1）处理过的鹿茸、薏苡仁以及步骤（2）处理后的鳖肉，小火炖煮2-5小时，停火前20-30分钟（优选停火前25分钟），加入步骤（3）所得煎液，加入食盐调味，即可。
5.如权利要求4所述的减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，其特征在于，步骤（1）中置于白酒中浸泡的时间为10-16小时（优选的置于白酒中浸泡的时间为12-14小时，更加优选的置于白酒中浸泡的时间为13小时）。
6.如权利要求4所述的减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，其特征在于，步骤（1）中过70-110目筛（优选的过80-100目筛，更加优选的过90目筛）。
7.如权利要求4所述的减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，其特征在于，步骤（2）中鳖置于沸水内煎煮的时间为1-3小时（优选的鳖置于沸水内煎煮的时间为1.5-2.5小时，更加优选的鳖置于沸水内煎煮的时间为2小时）。
8.如权利要求4所述的减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，其特征在于，步骤（2）中米醋和料酒的体积比为3:1.2。
9.如权利要求4所述的减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，其特征在于，步骤（3）中所加清水的量为药材量的3.5-6.5倍（优选的所加清水的量为药材量的4-6倍，更加优选的所加清水的量为药材量的5倍）。
10.如权利要求4所述的减轻化疗所致肝肾功能损伤副反应的保健药膳的制备方法，其特征在于，步骤（4）中小火炖煮3-4小时（优选的小火炖煮3.5小时）。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510008582.2A CN104489688B (zh) | 2015-01-08 | 2015-01-08 | 减轻化疗所致肝肾功能损伤副反应的保健药膳及制备 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510008582.2A CN104489688B (zh) | 2015-01-08 | 2015-01-08 | 减轻化疗所致肝肾功能损伤副反应的保健药膳及制备 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104489688A true CN104489688A (zh) | 2015-04-08 |
| CN104489688B CN104489688B (zh) | 2017-02-08 |
Family
ID=52931221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510008582.2A Active CN104489688B (zh) | 2015-01-08 | 2015-01-08 | 减轻化疗所致肝肾功能损伤副反应的保健药膳及制备 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104489688B (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104757570A (zh) * | 2015-04-27 | 2015-07-08 | 刘晓红 | 减轻放疗所致肝肾功能损伤的药膳及制法 |
| CN108697753A (zh) * | 2016-02-18 | 2018-10-23 | 韩国韩医学研究院 | 含有芦根提取物作为有效成分的用于预防、改善或治疗由抗癌剂的副作用引起的疾病的组合物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770217A (en) * | 1997-07-02 | 1998-06-23 | Atlatl, Inc. | Dietary supplement for hematological, immune and appetite enhancement |
| CN1332983A (zh) * | 2001-07-05 | 2002-01-30 | 李全能 | 荷花型保健饮料 |
| CN101703726A (zh) * | 2009-11-19 | 2010-05-12 | 何玉伟 | 一种治疗肺癌的药物 |
| CN104082717A (zh) * | 2014-06-08 | 2014-10-08 | 胡安然 | 一种肝肿瘤患者食用的微生态特殊膳食 |
-
2015
- 2015-01-08 CN CN201510008582.2A patent/CN104489688B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770217A (en) * | 1997-07-02 | 1998-06-23 | Atlatl, Inc. | Dietary supplement for hematological, immune and appetite enhancement |
| CN1332983A (zh) * | 2001-07-05 | 2002-01-30 | 李全能 | 荷花型保健饮料 |
| CN101703726A (zh) * | 2009-11-19 | 2010-05-12 | 何玉伟 | 一种治疗肺癌的药物 |
| CN104082717A (zh) * | 2014-06-08 | 2014-10-08 | 胡安然 | 一种肝肿瘤患者食用的微生态特殊膳食 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104757570A (zh) * | 2015-04-27 | 2015-07-08 | 刘晓红 | 减轻放疗所致肝肾功能损伤的药膳及制法 |
| CN108697753A (zh) * | 2016-02-18 | 2018-10-23 | 韩国韩医学研究院 | 含有芦根提取物作为有效成分的用于预防、改善或治疗由抗癌剂的副作用引起的疾病的组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104489688B (zh) | 2017-02-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102772737B (zh) | 用于治疗肝硬化纤维化的中药组合物及其制备方法 | |
| US10485834B2 (en) | Chinese herbal oral paste for conditioning phlegm-dampness constitution and processing method thereof | |
| CN105232911A (zh) | 一种中药组合物 | |
| CN102210839B (zh) | 一种治疗冠心病的中药胶囊 | |
| CN104489688B (zh) | 减轻化疗所致肝肾功能损伤副反应的保健药膳及制备 | |
| CN105381424A (zh) | 一种用于人体脏腑排毒的中药剂及制备方法 | |
| CN104873926A (zh) | 治疗腹泻的中药制剂及其制备方法与应用 | |
| CN108576341A (zh) | 一种可改善男性性功能的咖啡及制备方法 | |
| CN105999092A (zh) | 一种治疗结肠黑变病的中药药丸 | |
| CN110101818A (zh) | 一种治疗糖尿病的中药 | |
| CN106389965A (zh) | 一种治疗糖尿病的中药组合物及其制备方法 | |
| CN107362301A (zh) | 香苓开胃颗粒 | |
| CN105497546A (zh) | 治疗内痔的中药组合物及制法 | |
| CN105876712A (zh) | 一种健脾补肾富硒甘薯龟苓膏及其制备方法 | |
| CN105288492A (zh) | 一种用于直肠癌的中药制剂及其制备方法 | |
| CN103977213A (zh) | 用于治疗脾胃虚寒型慢性胃炎的保健药品 | |
| CN105288166A (zh) | 一种用于甲状腺肿大的中药组合物及其制备方法 | |
| CN103623355B (zh) | 一种治疗滑动性斜疝的中药制剂 | |
| CN104984149B (zh) | 一种与放疗配合使用的药物 | |
| CN104706866A (zh) | 一种治疗肠炎的中药制剂及制备方法 | |
| CN104906265A (zh) | 治疗冠心病的中药组合物 | |
| CN104491587A (zh) | 减轻化疗所致肝肾功能损伤副反应的药剂及制备 | |
| CN104606537A (zh) | 改善化疗所致心肌缺血损伤的益气养血药膳及制备方法 | |
| CN103920122B (zh) | 一种用于治疗胃肠炎的中药制剂及制备方法 | |
| CN113940989A (zh) | 一种抗肿瘤或失眠的中药组合物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Xu Yun Inventor after: Sun Jianwu Inventor after: Fu Xinhong Inventor after: Li Ling Inventor before: Zhao Yuhong |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160929 Address after: 264000 in Shandong Province, the Milky Way Development Zone Yantai Road, West Building 208 room powervision Applicant after: Zhu Luying Address before: 250000 Jianshe Road, Ji'nan, Shandong, No. 85 Applicant before: Li Hong |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20171205 Address after: 216100 Xiushan West Road, Haimen street, Haimen City, Jiangsu Province, No. 468 Patentee after: Haimen Mingchi Industrial Design Co.,Ltd. Address before: 264000 in Shandong Province, the Milky Way Development Zone Yantai Road, West Building 208 room powervision Patentee before: Zhu Luying |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230912 Address after: 226000 Haimen Economic and Technological Development Zone, Nantong City, Jiangsu Province, No. 999 Guangzhou Road Patentee after: Nantong Construction Engineering Co.,Ltd. Address before: 216100 No. 468 Xiushan Road, Haimen Street, Haimen City, Jiangsu Province Patentee before: Haimen Mingchi Industrial Design Co.,Ltd. |