CN104474437A - Traditional Chinese medicine dispersible tablets with functions of reducing turbidity and harmonizing stomach and preparation method thereof - Google Patents
Traditional Chinese medicine dispersible tablets with functions of reducing turbidity and harmonizing stomach and preparation method thereof Download PDFInfo
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- CN104474437A CN104474437A CN201410688704.2A CN201410688704A CN104474437A CN 104474437 A CN104474437 A CN 104474437A CN 201410688704 A CN201410688704 A CN 201410688704A CN 104474437 A CN104474437 A CN 104474437A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides traditional Chinese medicine dispersible tablets with the functions of reducing the turbidity and harmonizing the stomach and a preparation method thereof. The dispersible tablets are prepared from the following raw materials: 10-50% of traditional Chinese medicine extract, 10-80% of filling agent, 5-50% of internally added disintegrating agent, 5-15% of externally added disintegrating agent, 0.1-10% of flavoring agent, 0.1-20% of wetting agent, 0.05-5% of lubricating agent and 0.1-20% of flow aid, wherein the traditional Chinese medicine extract comprises the following raw materials: katsumade galangal seed, white mulberry root-bark, rhubarb, cardamom, grass leaf sweetflag rhizome and radish seed. The traditional Chinese medicine dispersible tablets are scientific in raw material selection and advanced in production process, have the functions of reducing the turbidity and harmonizing the stomach, tonifying the kidneys and the spleen and tonifying the stomach and stopping vomiting, have good solubility and dispersibility, high dissolution rates and good bioavailability, are fast in body distribution, have stable quality and good tastes, are convenient to take and can be swallowed and chewed.
Description
Technical field
the invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to dispersible tablets of Chinese medicine of a kind of lowering turbid pathogen to regulate the stomach and preparation method thereof.
Background technology
the disease of dyspepsia caused by gastric motility disorder, also comprises the bad gastroparesis of gastric peristalsis and esophageal reflux disease.Dyspepsia is mainly divided into functional dyspepsia and Organic dyspepsia.
cause dyspeptic reason a lot, comprise the chronic inflammatory disease of harmonization of the stomach duodenal site, make the normal creepage of gastrointestinal functions functional disorder of esophagus, Stomach duodenum.The spirit of patient is unhappy, depressed or be subject to suddenly fierce stimulation etc. and all can cause for a long time.
functional dyspepsia belongs to the category such as " gastral cavity painful abdominal mass ", " stomachache ", " noisy " of the traditional Chinese medical science.Its disease, at stomach, relates to liver spleen, and pathogenesis is mainly weakness of the spleen and stomach, disorder of QI movement, stomach-QI being unable to descend normally.Under normal physiological conditions, The spleen has the function to transport and transform nutrients, stomach receiving food and drink, the main liter of spleen and stomach master falls, and spleen happiness is dry and dislike wet, and stomach happiness is wet and dislike dry, in five elements' dependent territory.Liver controlling conveyance and dispersion, property happiness bar reaches, and belong to wood the five elements, long-term disorder of emotion, depression is not relaxed, and makes depression of liver-QI, catharsis mistake department, liver Wood restricts earth, and taste are become estranged; Eating and drinking too much at one meal, eating cold and uncooked food excessively, food indigested food, the tired resistance of phlegm-damp, spleen-QI failing to rise up, failure of stomach-QI to descend; Emptiness of spleen and stomach or overstrain impairing the spleen, deficiency of spleen-QI and stomach-QI, middle Jiao does not transport, and indigestion is polymerized to phlegm-damp, and then makes middle burnt ascending or descending movement of vital Qi not normal; Weakness of the spleen and stomach, strong fortune mistake department, water is anti-wet, and paddy is anti-stagnant, and humidity hysteresis Yu Huare of a specified duration, cold and heat tie gastral cavilty mutually.Above end causes gastrointestinal motility dysfunction, on then uncomfortable in chestly to choke with sobs, in then epigastric distending pain, under then constipation; Failure of stomach-QI to descend is counter to be risen, then belch acid regurgitation, vomits heartburn etc.; Spleen-QI failing to rise up is counter to fall, then gastral cavilty falling inflation appears in sinking of QI of middle-JIAO, and indigestion and loss of appetite morning satisfies, and defecates from incontinent diarrhea.So when treating functional dyspepsia, note invigorating the spleen and regulating the stomach, depressed liver-energy dispersing and QI regulating, temper must be risen, and gastric qi must be fallen, and irritability must be relaxed, and disease then must be controlled.
there is the medicine of a lot for the treatment of gastropathy in the market, but great majority are only temporary transient relief of symptoms, and containing toxin in most drug, side effect is more, can damage health, therefore, market is badly in need of a kind of pure natural, the dispersible tablets of Chinese medicine of lowering turbid pathogen to regulate the stomach that has no side effect and preparation method thereof.
Summary of the invention
the object of this invention is to provide dispersible tablets of Chinese medicine of a kind of lowering turbid pathogen to regulate the stomach and preparation method thereof.
object of the present invention is achieved through the following technical solutions: a kind of dispersible tablets of Chinese medicine of kidney tonifying the turbid descending, by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, fluidizer, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 80%, in disintegrating agent 5 ~ 50%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 20%, lubricant 0.05 ~ 5%, fluidizer 0.1 ~ 20%; The preferred weight number proportioning of described Chinese medicine extract Raw is: Semen Alpiniae Katsumadai 15-35 part, Cortex Mori 15-35 part, Radix Et Rhizoma Rhei 10-20 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Acori Graminei 10-30 part, Semen Raphani 20-40 part.
the dispersible tablets of Chinese medicine of described a kind of kidney tonifying the turbid descending, the optimum weight number proportioning of described Chinese medicine extract Raw is: Semen Alpiniae Katsumadai 25 parts, Cortex Mori 25 parts, Radix Et Rhizoma Rhei 15 parts, 25 parts, Fructus Amomi Rotundus, Rhizoma Acori Graminei 20 parts, Semen Raphani 30 parts.
the dispersible tablets of Chinese medicine of described a kind of kidney tonifying the turbid descending, by weight, Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 80 parts, in disintegrating agent 5 ~ 50 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 20 part, lubricant 0.05 ~ 5 part, fluidizer 0.1 ~ 20 part.
the dispersible tablets of Chinese medicine of described a kind of kidney tonifying the turbid descending, by optimum weight number proportioning, Chinese medicine extract 46 parts, filler 30 parts, in disintegrating agent 20 parts, additional disintegrating agent 13 parts, correctives 6 parts, wetting agent 6 parts, lubricant 3 parts, fluidizer 2 parts.
the dispersible tablets of Chinese medicine of described a kind of kidney tonifying the turbid descending, described filler is the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; Be the mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
the dispersible tablets of Chinese medicine of described a kind of kidney tonifying the turbid descending, the concrete steps of its preparation method are:
step 1, to get the raw materials ready: proportioning by weight, choose the Semen Alpiniae Katsumadai of high-quality, Cortex Mori, Radix Et Rhizoma Rhei, Fructus Amomi Rotundus, Rhizoma Acori Graminei, Semen Raphani, clean and remove impurity, and by the little fiery parch 5-10 minute of Semen Raphani, for subsequent use;
step 2: extract: by Semen Alpiniae Katsumadai, Cortex Mori, Radix Et Rhizoma Rhei, Fructus Amomi Rotundus, Rhizoma Acori Graminei, Semen Raphani, decoct with water secondary, first time adds 10 times amount soak by water 2 hours, second time adds 8 times of soak by water 1.5 hours, collecting decoction, filters, and filtrate concentrates, make it under the temperature conditions of 80 ~ 85 DEG C, being concentrated into relative density is 1.2, is cooled to room temperature, adds appropriate ethanol and makes alcohol content reach 70%, static 24 hours precipitations, get supernatant concentration, make it under the temperature conditions of 60-65 DEG C, relative density is the clear paste of 1.2-1.25,80 DEG C of drying under reduced pressure, obtain extract;
step 3, preparation: extract is ground into fine powder, cross 80 mesh sieves, add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, obtain granulate, high temperature drying, adopts ultraviolet disinfection, by granulate, additional disintegrating agent, correctives, lubricant, fluidizer mix homogeneously, tabletting, obtains a kind of dispersible tablets of Chinese medicine of kidney tonifying the turbid descending.
in medicine: Semen Alpiniae Katsumadai, dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, for internal retention of cold wetness, distension and fullness in the abdomen cold type of pain, belch vomiting, the cards such as anorexia, Cortex Mori, eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, Radix Et Rhizoma Rhei, purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, for excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, burn due to hot liquid or fire, upper gastrointestinal hemorrhage, Fructus Amomi Rotundus, removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving, for turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear, Rhizoma Acori Graminei, removing dampness is whetted the appetite, to have one's ideas straightened out eliminating phlegm, refreshment Fructus Alpiniae Oxyphyllae, not hungry for gastral cavity painful abdominal mass, to keep silent a mouthful dysentery, coma epilepsy, forgetful deafness, regulate the flow of vital energy, invigorate blood circulation, loose wind, dry, control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury, Semen Raphani, help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm, cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch.
beneficial effect of the present invention: the dispersible tablets of Chinese medicine of a kind of lowering turbid pathogen to regulate the stomach of the present invention, there is effect of lowering turbid pathogen to regulate the stomach, kidney and spleen invigorating, arresting vomiting by invigorating the stomach, its dissolubility, favorable dispersibility, dissolution is high, and bioavailability is good, distribution in vivo is rapid, steady quality, mouthfeel is good, taking convenience, can swallow, chew, containing sucking or taking with after aqueous dispersion, be more suitable for old man and the patient of difficulty of swallowing, there is medicine stability good, packaging, transport, the advantages such as storage is convenient, its preparation method is simple, is applicable to commercial production.
the present invention is through two groups of clinical verifications, and wherein one group is that treatment group takes the present invention, takes the present invention every day once, within 15 days, be a course for the treatment of, another group matched group uses XIANGSHA YANGWEI WAN, and every day uses once, within 15 days, be a course for the treatment of, select outpatient 152 example altogether, wherein man 41 example, female 111 example, max age 75 years old, minimal ages 35 years old, clinical manifestation is gastral cavilty falling inflation, indigestion and loss of appetite morning satisfies, and defecate from incontinent diarrhea, table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.
process characteristic of the present invention: 1, select raw material science, production technology is advanced, and its product is conveniently deposited and used; 2, product Chinese medicine composition is easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
embodiment 1
a kind of dispersible tablets of Chinese medicine of kidney tonifying the turbid descending, by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, fluidizer, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 80%, in disintegrating agent 5 ~ 50%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 20%, lubricant 0.05 ~ 5%, fluidizer 0.1 ~ 20%; The preferred weight number proportioning of described Chinese medicine extract Raw is: Semen Alpiniae Katsumadai 15-35 part, Cortex Mori 15-35 part, Radix Et Rhizoma Rhei 10-20 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Acori Graminei 10-30 part, Semen Raphani 20-40 part.
embodiment 2
a dispersible tablets of Chinese medicine for kidney tonifying the turbid descending, the optimum weight number proportioning of described Chinese medicine extract Raw is: Semen Alpiniae Katsumadai 25 parts, Cortex Mori 25 parts, Radix Et Rhizoma Rhei 15 parts, 25 parts, Fructus Amomi Rotundus, Rhizoma Acori Graminei 20 parts, Semen Raphani 30 parts.
embodiment 3
a kind of dispersible tablets of Chinese medicine of kidney tonifying the turbid descending, proportioning by weight, Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 80 parts, in disintegrating agent 5 ~ 50 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 20 part, lubricant 0.05 ~ 5 part, fluidizer 0.1 ~ 20 part.
embodiment 4
a dispersible tablets of Chinese medicine for kidney tonifying the turbid descending, by optimum weight number proportioning, Chinese medicine extract 46 parts, filler 30 parts, in disintegrating agent 20 parts, additional disintegrating agent 13 parts, correctives 6 parts, wetting agent 6 parts, lubricant 3 parts, fluidizer 2 parts.
embodiment 5
a dispersible tablets of Chinese medicine for kidney tonifying the turbid descending, described filler is the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; Be the mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
embodiment 6
a dispersible tablets of Chinese medicine for kidney tonifying the turbid descending, the concrete steps of its preparation method are:
step 1, to get the raw materials ready: proportioning by weight, choose the Semen Alpiniae Katsumadai of high-quality, Cortex Mori, Radix Et Rhizoma Rhei, Fructus Amomi Rotundus, Rhizoma Acori Graminei, Semen Raphani, clean and remove impurity, and by the little fiery parch 5-10 minute of Semen Raphani, for subsequent use;
step 2: extract: by Semen Alpiniae Katsumadai, Cortex Mori, Radix Et Rhizoma Rhei, Fructus Amomi Rotundus, Rhizoma Acori Graminei, Semen Raphani, decoct with water secondary, first time adds 10 times amount soak by water 2 hours, second time adds 8 times of soak by water 1.5 hours, collecting decoction, filters, and filtrate concentrates, make it under the temperature conditions of 80 ~ 85 DEG C, being concentrated into relative density is 1.2, is cooled to room temperature, adds appropriate ethanol and makes alcohol content reach 70%, static 24 hours precipitations, get supernatant concentration, make it under the temperature conditions of 60-65 DEG C, relative density is the clear paste of 1.2-1.25,80 DEG C of drying under reduced pressure, obtain extract;
step 3, preparation: extract is ground into fine powder, cross 80 mesh sieves, add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, obtain granulate, high temperature drying, adopts ultraviolet disinfection, by granulate, additional disintegrating agent, correctives, lubricant, fluidizer mix homogeneously, tabletting, obtains a kind of dispersible tablets of Chinese medicine of kidney tonifying the turbid descending.
Claims (6)
1. the dispersible tablets of Chinese medicine of a kidney tonifying the turbid descending, it is characterized in that: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, fluidizer, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 80%, in disintegrating agent 5 ~ 50%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 20%, lubricant 0.05 ~ 5%, fluidizer 0.1 ~ 20%; The preferred weight number proportioning of described Chinese medicine extract Raw is: Semen Alpiniae Katsumadai 15-35 part, Cortex Mori 15-35 part, Radix Et Rhizoma Rhei 10-20 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Acori Graminei 10-30 part, Semen Raphani 20-40 part.
2. the dispersible tablets of Chinese medicine of a kind of kidney tonifying the turbid descending according to claim 1, is characterized in that: the optimum weight number proportioning of described Chinese medicine extract Raw is: Semen Alpiniae Katsumadai 25 parts, Cortex Mori 25 parts, Radix Et Rhizoma Rhei 15 parts, 25 parts, Fructus Amomi Rotundus, Rhizoma Acori Graminei 20 parts, Semen Raphani 30 parts.
3. the dispersible tablets of Chinese medicine of a kind of kidney tonifying the turbid descending according to claim 1, it is characterized in that: proportioning by weight, Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 80 parts, in disintegrating agent 5 ~ 50 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 20 part, lubricant 0.05 ~ 5 part, fluidizer 0.1 ~ 20 part.
4. the dispersible tablets of Chinese medicine of a kind of kidney tonifying the turbid descending according to claim 1, it is characterized in that: by optimum weight number proportioning, Chinese medicine extract 46 parts, filler 30 parts, in disintegrating agent 20 parts, additional disintegrating agent 13 parts, correctives 6 parts, wetting agent 6 parts, lubricant 3 parts, fluidizer 2 parts.
5. the dispersible tablets of Chinese medicine of a kind of kidney tonifying the turbid descending according to claim 1, is characterized in that: described filler is the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; Be the mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, essence; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
6. the dispersible tablets of Chinese medicine of a kind of kidney tonifying the turbid descending according to claim 1-5, is characterized in that: the concrete steps of its preparation method are:
Step 1, to get the raw materials ready: proportioning by weight, choose the Semen Alpiniae Katsumadai of high-quality, Cortex Mori, Radix Et Rhizoma Rhei, Fructus Amomi Rotundus, Rhizoma Acori Graminei, Semen Raphani, clean and remove impurity, and by the little fiery parch 5-10 minute of Semen Raphani, for subsequent use;
Step 2: extract: by Semen Alpiniae Katsumadai, Cortex Mori, Radix Et Rhizoma Rhei, Fructus Amomi Rotundus, Rhizoma Acori Graminei, Semen Raphani, decoct with water secondary, first time adds 10 times amount soak by water 2 hours, second time adds 8 times of soak by water 1.5 hours, collecting decoction, filters, and filtrate concentrates, make it under the temperature conditions of 80 ~ 85 DEG C, being concentrated into relative density is 1.2, is cooled to room temperature, adds appropriate ethanol and makes alcohol content reach 70%, static 24 hours precipitations, get supernatant concentration, make it under the temperature conditions of 60-65 DEG C, relative density is the clear paste of 1.2-1.25,80 DEG C of drying under reduced pressure, obtain extract;
Step 3, preparation: extract is ground into fine powder, cross 80 mesh sieves, add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, obtain granulate, high temperature drying, adopts ultraviolet disinfection, by granulate, additional disintegrating agent, correctives, lubricant, fluidizer mix homogeneously, tabletting, obtains a kind of dispersible tablets of Chinese medicine of kidney tonifying the turbid descending.
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