CN104027659A - Traditional Chinese medicine particle for treating hiatus hernia and preparing method thereof - Google Patents
Traditional Chinese medicine particle for treating hiatus hernia and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine particle for treating hiatus hernia and a preparing method thereof. The traditional Chinese medicine particle is formed by preparing, by weight, 9-15 parts of fushen, 3-10 parts of fructus evodiae, 5-20 parts of semen raphani, 10-25 parts of bamboo shavings, 2-8 parts of liquoric roots, 4-12 parts of navodon modestus, 10-20 parts of cortex magnoliae officinalis, 3-6 parts of concha arcae, 12-20 parts of perilla leaves, 5-13 parts of asterias rollestoni, 4-12 parts of scutellaria baicalensis and 6-12 parts of cuttle bones. The traditional Chinese medicine particle for treating the hiatus hernia has the effects of nourishing the spleen, benefiting qi and promoting circulation of qi and the stomach, is capable of healing the hiatus hernia fundamentally, scientific in composition, safe and reliable, and will not bring any toxic side effect to patients.
Description
Technical field
The invention discloses a kind of Chinese medicinal granule for the treatment of hiatal hernia and preparation method thereof, dosage form is granule, belongs to Chinese medicine field.
Background technology
Hiatal hernia refers to that abdominal visceral browser (being mainly stomach) enters the disease due to thoracic cavity by hiatus esophageus of diaphragm.Hiatal hernia is the most common in diaphragmatocele, reaches more than 90%, belongs to Digestive System Department disease.Hiatal hernia patient can be asymptomatic or symptom is slight, and the order of severity of its symptom weight and hernical sac size, esophagitis is irrelevant.Primary disease can betide any age, but the appearance of symptom increases with age growth.Primary disease sickness rate in population generaI investigation is 0.52%, and in the conventional gastrointestinal x-ray barium meal examination that has suspicious hiatal hernia symptom, the recall rate of sliding hiatus hernia is 11.8%.In the time that x-ray checks, adopt in recent years special posture pressurization, its recall rate can reach 80%.Because how asymptomatic primary disease is or symptom is slight, therefore be difficult to the sickness rate that show that it is definite.Primary disease women, more than male, is 1.5～3:1.Cause the reason of hiatal hernia mainly contain following some: 1. the undergrown congenital factors of esophagus.2. esophageal hiatus portion structure, weakens as muscle has atrophy or muscle tone.3. the acquired disposition that long-term abdominal pressure increases, as gestation, seroperitoneum, chronic cough, habitual constipation etc. can make body of stomach hernia enter on diaphram and formation hiatal hernia.4. ceasma hernia after operation, as epigastric or pars cardiaca operation, has destroyed normal structure and also can cause hernia.5. traumatic ceasma hernia.
The clinical manifestation of hiatal hernia has: 1, gastroesophageal reflux symptom: dislike, Abdeminal pain, belch, pain etc. after performance breastbone or in burn feeling under xiphoid-process, gastric content.Characteristic of pain mostly is burn feeling or acupuncture sample pain, can be radiated to back, shoulder, cervical region etc. and locate.Flat sleeping, take food sweet food, acidic food, all may bring out and can increase the weight of symptom.This symptom is especially common with sliding hiatal hernia.2, complication: (1) is hemorrhage: ceasma hernia sometimes can be hemorrhage, is mainly due to esophagitis and hernical sac inflammation, mostly is chronic a small amount of oozing of blood, can cause anemia.The harmonization of the stomach intestinal generation ulcer that hernia enters can cause hematemesis and melena.(2) anti-fluidity esophagostenosis: having in reflux symptom patient, minority generation organic stenosis, so that occur dysphagia, swallows pain, the symptom such as vomiting after food.(3) hernical sac incarceration: generally see paraesophageal hernia.Ceasma hernia patient, as suddenly violent upper abdominal pain companion vomiting, can not swallow completely or massive hemorrhage occurs simultaneously, and acute incarceration occurs in prompting.3. hernical sac pressure symptom: in the time of the larger compressing cardiopulmonary of hernical sac, mediastinum, can produce the symptoms such as out of breath, cardiopalmus, cough, cyanosis.When compressing esophagus, can feel after breastbone, have retention of food or dysphagia.
In modern medicine, the treatment of hiatal hernia is mainly contained following several:
1. medical treatment.Be applicable to small-sized sliding hernia and reflux symptom compared with the lighter.Therapeutic Principle eliminates the factor that hernia forms, and controls gastroesophageal reflux, promotes that esophagus is emptying and relaxes or reduce the secretion of gastric acid.Mainly comprise: (1) lifestyle change, 1. reduce appetite, taking high protein, low fat diet as main, avoid coffee, chocolate, drink etc., avoid putting down after the meal sleeping and Food intake before bed.2. while sleep, get head height foot low level, when clinostatism, raise the head of a bed.3. avoid bending over, be in tights, vomiting etc. increases the factor of intra-abdominal pressure.4. overweight people should manage to lose weight, and has chronic cough, and prolonged constipation person should manage treatment.Can suitably give above-mentioned treatment for asymptomatic hiatal hernia and little ceasma hernia person.(2) Drug therapy, for burning after existing chest pain, breastbone, the gastroesophageal reflux symptom such as acid regurgitation or regurgitation after the meal, except above preventive measure, then gives anti-reflux and protection Esophageal Mucosa medicine, dynamics-promoting medicine etc.Medical treatment is only applicable to the patient that symptom is lighter, and long-term taking Western medicine can bring a series of side effect.
2. surgical intervention.(1) operation indication: 1. hiatal hernia, medical treatment poor effect.2. hiatal hernia exists pyloric obstruction, duodenum to be retarded by silt simultaneously.3. paraesophageal hiatus hernia and huge ceasma hernia.4. hiatal hernia is suspected canceration.(2) operative Principle: hernial content 1. resets.2. repair lax weak esophageal hiatus.3. prevent and treat gastroesophageal reflux.4. keep stomach efferent tract unobstructed.5. the double complication of controlling and depositing.(3) operation method: the operation method for the treatment of hiatal hernia is a lot, is mainly herniorrhaphy and anti-reflux operation.Though the slight illness that operating therapeuticing esophagus ceasma hernia can reduction of patient, after operation, also can bring such as esophageal regurgitation problem can not fundamentally solve, the problem such as breast abdomen sense of discomfort.
Publication number is CN 1376061A(application number 00807531.X) Chinese patent literature a kind of by name " about the treatment of hiatal hernia " disclosed, it forms by giving its formula I compound that needs the effective therapeutic dose of patient and pharmaceutically acceptable diluent or carrier.Application publication number is CN 103330789A(application number 201310253992.4) Chinese patent literature a kind of by name " a kind of Chinese medicine for the treatment of hiatal hernia " is disclosed, this Chinese medicine is by 10 parts of Fructus Phyllanthis, 12 parts of Tibet Herba Incarvilleae sinensiss, 8 parts of Herba Rorippae, 8 parts, row's money tree, 8 parts of Radix Angelicae Sinensis, towards 12 parts of emperors, 12 parts of Radix haleniae ellipticaes, 14 parts of Herba Violae diamantiacaes, 14 parts of Lan Huashi ginsengs, 14 parts of Radix Polygoni Multiflori, 12 parts of Radix calophylli membranacei, 8 parts of little Herba Saxifragaes, 10 parts of Ramulus et Folium Semiliquidambaris cathayensis, 10 parts of Herba Gentianae Urnulaes, 10 parts of post fruit Radix clematidis floridaes, 10 parts of Cucurbita pepo L.var.Akoda Mak.(C.pepo L.Var.kintoga Mak.), 10 parts of Radix Apioris Fortunei, 12 parts of Herba Asplenii Incisis, 8 parts of compositions of Bud of hairyvein agrimony.
In a word, Chinese medicine is being obtained certain effect aspect treatment hiatal hernia, but also has following point: esophageal regurgitation problem does not fundamentally solve, and some medicine can bring certain side effect to patient, therefore needs to be further improved.
Summary of the invention
For the slightly not enough present situation of prior art, the object of the present invention is to provide a kind of Chinese medicinal granule for the treatment of hiatal hernia and preparation method thereof, there is simple to operate, taking convenience, the advantage such as be easy to carry about with one, and can, from basic healing hiatal hernia, effectively make up above-mentioned deficiency.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicinal granule for hiatal hernia, take off the primary raw material of stating weight proportion and be prepared from: Poria cum Radix Pini 9-15 part, Fructus Evodiae 3-10 part, Semen Raphani 5-20 part, Caulis Bambusae In Taenia 10-25 part, Radix Glycyrrhizae 2-8 part, black scraper Puffer 4-12 part, Cortex Magnoliae Officinalis 10-20 part, Concha Arcae 3-6 part, Folium Perillae 12-20 part, starfish 5-13 part, Radix Scutellariae 4-12 part, Os Sepiae 6-12 part.
Treat a Chinese medicinal granule for hiatal hernia, preferred scheme is, takes off the primary raw material of stating weight proportion and is prepared from: Poria cum Radix Pini 11-13 part, Fructus Evodiae 5-7 part, Semen Raphani 10-15 part, Caulis Bambusae In Taenia 12-20 part, Radix Glycyrrhizae 4-6 part, black scraper Puffer 6-10 part, Cortex Magnoliae Officinalis 13-17 part, Concha Arcae 4-5 part, Folium Perillae 14-18 part, starfish 7-11 part, Radix Scutellariae 6-10 part, Os Sepiae 8-10 part.
Treat a Chinese medicinal granule for hiatal hernia, the scheme being more preferably is, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Poria cum Radix Pinis, 6 parts of Fructus Evodiaes, 12 parts of Semen Raphanis, 16 parts of Caulis Bambusae In Taenia, 5 parts, Radix Glycyrrhizae, 8 parts of black scraper Puffer, 15 parts of Cortex Magnoliae Officinalis, 4.5 parts of Concha Arcaes, 16 parts of Folium Perillaes, 9 parts of starfishes, 8 parts of Radix Scutellariaes, 9 parts of Os Sepiae.
The preparation method of above-mentioned a kind of Chinese medicinal granule for the treatment of hiatal hernia, step is as follows:
(1) Semen Raphani, Cortex Magnoliae Officinalis, Concha Arcae, Radix Scutellariae, Os Sepiae are pulverized, sieved, then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, Radix Glycyrrhizae and black scraper Puffer are placed in non iron container, add water standing, decoct twice, after decocting for the first time, add Folium Perillae and starfish, decoct for the second time, filter twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then make specification according to Chinese medicine granules, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
The preparation method of above-mentioned a kind of Chinese medicinal granule for the treatment of hiatal hernia, preferred scheme is that step (1) is crossed 70-130 mesh sieve and (preferably, crossed 80-120 mesh sieve; Be more preferably, cross 100 mesh sieves).
The preparation method of above-mentioned a kind of Chinese medicinal granule for the treatment of hiatal hernia, preferred scheme is, the consumption of step (1) ethanol is that the 5-9 of each crude drug gross weight is doubly (preferred, the consumption of ethanol is 6-8 times of each crude drug gross weight, be more preferably, the consumption of ethanol is 7 times of each crude drug gross weight).
The preparation method of above-mentioned a kind of Chinese medicinal granule for the treatment of hiatal hernia, preferably scheme is, and it is that 40%-70%(is preferred that step (1) adds the concentration of ethanol, and the concentration that adds ethanol is 50%-60%; Be more preferably, the concentration that adds ethanol is 55%).
The preparation method of above-mentioned a kind of Chinese medicinal granule for the treatment of hiatal hernia, preferred scheme is, step (2) water consumption be each crude drug gross weight 2-4 doubly (preferred, water consumption be each crude drug gross weight 2.5-3.5 doubly; Be more preferably, water consumption is 3 times of each crude drug gross weight).
The preparation method of above-mentioned a kind of Chinese medicinal granule for the treatment of hiatal hernia, preferred scheme is that step (2) decocts for the first time and (preferably, decocts for the first time 40-60 minute in 30-70 minute; Be more preferably, decoct for the first time 50 minutes).
The preparation method of above-mentioned a kind of Chinese medicinal granule for the treatment of hiatal hernia, preferred scheme is that step (2) decocts for the second time and (preferably, decocts for the second time 30-50 minute in 25-55 minute; Be more preferably, decoct for the second time 40 minutes).
Best using method: for making the present invention reach best therapeutic effect, one day twice, each one bag, dissolved with the warm water 200ml of 50 DEG C of left and right, before noon supper, took half an hour, 10 days courses for the treatment of.
The pharmacological effect of each raw material is respectively:
Poria cum Radix Pini: base is former: Poria cum Radix Pini is the sclerotium of the sleeping hole of Polyporaceae platymiscium Poria.Nature and flavor: sweet, light, flat.Gui Jing: GUIXIN, spleen channel.Effect: mind calming, calm the nerves, diuretic.Cure mainly: control the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Fructus Evodiae: acrid in the mouth, hardship, hot in nature; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Effect: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Cure mainly: the sun headache of fainting, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea.
Semen Raphani: acrid in the mouth, sweet, property is flat.Return lung, spleen, stomach warp.Effect: the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.Cure mainly: retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Caulis Bambusae In Taenia: sweet in the mouth, cold nature.Attach to the lung and stomach meridians.Effect: removing heat-phlegm, relieves restlessness and prevents vomiting.Curing mainly: phlegm-heat cough. gallbladder fire is held expectorant under the arm, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.
Radix Glycyrrhizae: sweet in the mouth, property is flat.GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, can coordinating the actions of various ingredients in a prescription, cushion toxicity, strong.
Black scraper Puffer: have another name called peeling youth, rubber fish, bread fish, peeling fish, belong to the meat of animal Navodon septentrionalis for removing from office Molidae black scraper Puffer.The property of medicine: sweet in the mouth, property is flat.Composition: skin and flesh contains protein, fat, aminoacid, calcium, phosphorus, ferrum, and contain actomyosin.Find according to modern pharmacological research, this medical instrument has effect of hemostasis removing toxic substances, invigorating the stomach and promoting digestion, for digestive tract hemorrhage, and traumatic hemorrhage, gastropathy, gastritis, mastitis.
Cortex Magnoliae Officinalis: nature and flavor: bitter in the mouth, pungent, warm in nature.Gui Jing: return spleen, stomach, lung, large intestine channel.Effect: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.Cure mainly: humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Concha Arcae: have another name called Carnis Arca inflata shell, watt room, blood clam skin, row of tiles on a roof clam skin, for Carnis Arca inflata section Carnis Arca inflata belongs to the shell that animal Scapharca subcrenata, Scapharca broughtonii and Tegillarca granosa belong to animal Tegillarca granosa.The property of medicine: matter heavily fortified point, sweet in the mouth, salty, property is flat.Composition: main component is calcium carbonate, also contains a small amount of calcium phosphate and magnesium, ferrum, silicate.Find according to modern pharmacological research, this medical instrument has effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for pertinacious phlegm chronic cough, and stomachache acid regurgitation, traumatic hemorrhage, gastric and duodenal ulcers.
Folium Perillae: nature and flavor: acrid in the mouth, warm in nature.Gui Jing: return lung, spleen channel.Effect: the cold expelling that induces sweat, relieving QI stagnancy in the stomach.Cure mainly: anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.
Starfish: for a sea dish gram starfish belongs to animal Roche sea dish.Asterias amurensis all.Composition: contain trypsin, isozyme, actin, myosin, serine, histidine containing digestive organs.Pharmacology: have the effect of anti-gastric-ulcer, there is antishock effect, have antineoplastic action.The property of medicine: property is flat, salty in the mouth.Enter liver, stomach, kidney channel.Function cures mainly: suppressing the hyperactive liver shock, Anti-acid and regulating stomach, heat-clearing and toxic substances removing.Pain relieving, antacid.
Radix Scutellariae: nature and flavor: bitter in the mouth, cold in nature.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, rush down people's removing toxic substances, hemostasis, antiabortive.Cure mainly: hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Os Sepiae: have another name called: flower rock, numb black Quarry.Nature and flavor: salty, puckery, temperature.Gui Jing: return spleen, kidney channel.Effect: astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Cure mainly: for Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, the many pus of skin ulcer.Dehumidifying, antacid, hemostasis, sore.The acid regurgitation that treats for stomachache, tells, nosebleed, hematemesis, has blood in stool, and bleeding not during menses, amenorrhea due to blood depletion, stomachache lump in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.
The Chinese medicinal granule that the present invention treats hiatal hernia has effect of invigorating the spleen and replenishing QI, relieving QI stagnancy in the stomach, can fundamentally cure hiatal hernia, and prescription science, safe and reliable, can not bring any toxic and side effects to patient.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat a Chinese medicinal granule for hiatal hernia, take off the primary raw material of stating weight proportion and be prepared from (getting 5g for every part): 9 parts of Poria cum Radix Pinis, 3 parts of Fructus Evodiaes, 5 parts of Semen Raphanis, 10 parts of Caulis Bambusae In Taenia, 2 parts, Radix Glycyrrhizae, 4 parts of black scraper Puffer, 10 parts of Cortex Magnoliae Officinalis, 3 parts of Concha Arcaes, 12 parts of Folium Perillaes, 5 parts of starfishes, 4 parts of Radix Scutellariaes, 6 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Semen Raphani, Cortex Magnoliae Officinalis, Concha Arcae, Radix Scutellariae, Os Sepiae are pulverized, cross 70 mesh sieves, then add 40% ethanol (ethanol consumption is 5 times of each crude drug gross weight), sealing is placed in shady and cool ventilation place and leaves standstill, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, Radix Glycyrrhizae and black scraper Puffer being placed in non iron container to add water (water consumption is 2 times of each crude drug gross weight) leaves standstill, decoct twice, decoct for the first time 30 minutes, add Folium Perillae and starfish, decoct for the second time, the time is 25 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then make specification according to Chinese medicine granules, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
model case one:money XX, female, 31 years old., there is sometimes cardiopalmus, the disease such as nervous, and after breastbone, have burn feeling in the malaise symptoms such as belch appears in patient's readme recently, feel sick, and be radiated to back, cervical region etc. and locate, now without appetite, easily regurgitation, receive food seldom, become thin abnormal, remove examination in hospital, be diagnosed as hiatal hernia, take some medicines in hospital, after taking, effect is alleviated to some extent, but can not cure.Take the present embodiment 1 gained Chinese medicinal granule, adopt one day twice, each one bag, dissolved with the warm water 200ml of 50 DEG C of left and right, before noon supper, take half an hour, 10 days courses for the treatment of.Take 5 days, patient's malaise symptoms all alleviates, nauseating, belch transference cure; Take 10 days, patient's partial symptoms disappears, and the food of receiving increases; Continue to take 5 days, patient's malaise symptoms disappears completely, takes check after 1 month, and esophageal regurgitation problem is cured, and hiatal hernia is fundamentally cured.
embodiment 2treat a Chinese medicinal granule for hiatal hernia, take off the primary raw material of stating weight proportion and be prepared from (getting 10g for every part): 15 parts of Poria cum Radix Pinis, 10 parts of Fructus Evodiaes, 20 parts of Semen Raphanis, 25 parts of Caulis Bambusae In Taenia, 8 parts, Radix Glycyrrhizae, 12 parts of black scraper Puffer, 20 parts of Cortex Magnoliae Officinalis, 6 parts of Concha Arcaes, 20 parts of Folium Perillaes, 13 parts of starfishes, 12 parts of Radix Scutellariaes, 12 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Semen Raphani, Cortex Magnoliae Officinalis, Concha Arcae, Radix Scutellariae, Os Sepiae are pulverized, cross 130 mesh sieves, then add 70% ethanol (ethanol consumption is 9 times of each crude drug gross weight), sealing is placed in shady and cool ventilation place and leaves standstill, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, Radix Glycyrrhizae and black scraper Puffer being placed in non iron container to add water (water consumption is 4 times of each crude drug gross weight) leaves standstill, decoct twice, decoct for the first time 70 minutes, add Folium Perillae and starfish, decoct for the second time, the time is 55 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then make specification according to Chinese medicine granules, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
embodiment 3treat a Chinese medicinal granule for hiatal hernia, take off the primary raw material of stating weight proportion and be prepared from (getting 15g for every part): 11 parts of Poria cum Radix Pinis, 5 parts of Fructus Evodiaes, 10 parts of Semen Raphanis, 12 parts of Caulis Bambusae In Taenia, 4 parts, Radix Glycyrrhizae, 6 parts of black scraper Puffer, 13 parts of Cortex Magnoliae Officinalis, 4 parts of Concha Arcaes, 14 parts of Folium Perillaes, 7 parts of starfishes, 6 parts of Radix Scutellariaes, 8 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Semen Raphani, Cortex Magnoliae Officinalis, Concha Arcae, Radix Scutellariae, Os Sepiae are pulverized, cross 80 mesh sieves, then add 50% ethanol (ethanol consumption is 6 times of each crude drug gross weight), sealing is placed in shady and cool ventilation place and leaves standstill, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, Radix Glycyrrhizae and black scraper Puffer being placed in non iron container to add water (water consumption is 2.5 times of each crude drug gross weight) leaves standstill, decoct twice, decoct for the first time 40 minutes, add Folium Perillae and starfish, decoct for the second time, the time is 30 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then make specification according to Chinese medicine granules, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
model case two:wu XX, man, 46 years old.Burn feeling after patient's breastbone, existing six months of regurgitation acid symptom, many medicines are taken over the past half year, all undesirable, patient is fond of drinking, stomach pain, acid regurgitation and without appetite after drinking, patient before 10 days because of friend's heavy drinking of meeting, stomach pain after drinking, Abdeminal pain, therefore not feed in 1 day starts to receive food afterwards, the food of receiving is less, occur afterwards on the feed feeling sick, belch, the disease such as have a stomach-ache, and after breastbone, burn feeling obviously increases the weight of, and is radiated to shoulder, back, remove examination in hospital, be diagnosed as hiatal hernia, take western medicine, invalid.Take the present embodiment 3 gained Chinese medicinal granules, adopt one day twice, each one bag, dissolved with the warm water 200ml of 50 DEG C of left and right, before noon supper, take half an hour, 10 days courses for the treatment of.Take 3 days, the transference cure of feeling sick, malaise symptoms is alleviated to some extent; Take 10 days, after patient's breastbone, burn feeling obviously alleviates, and appetite strengthens before; Continue to take 10 days, patient's malaise symptoms disappears completely, and self-induction recovery from illness, continues to take and consolidated for 20 days, does not occur any discomfort symptom during taking.
embodiment 4treat a Chinese medicinal granule for hiatal hernia, take off the primary raw material of stating weight proportion and be prepared from (getting 20g for every part): 13 parts of Poria cum Radix Pinis, 7 parts of Fructus Evodiaes, 15 parts of Semen Raphanis, 20 parts of Caulis Bambusae In Taenia, 6 parts, Radix Glycyrrhizae, 10 parts of black scraper Puffer, 17 parts of Cortex Magnoliae Officinalis, 5 parts of Concha Arcaes, 18 parts of Folium Perillaes, 11 parts of starfishes, 10 parts of Radix Scutellariaes, 10 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Semen Raphani, Cortex Magnoliae Officinalis, Concha Arcae, Radix Scutellariae, Os Sepiae are pulverized, cross 120 mesh sieves, then add 60% ethanol (ethanol consumption is 8 times of each crude drug gross weight), sealing is placed in shady and cool ventilation place and leaves standstill, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, Radix Glycyrrhizae and black scraper Puffer being placed in non iron container to add water (water consumption is 3.5 times of each crude drug gross weight) leaves standstill, decoct twice, decoct for the first time 60 minutes, add Folium Perillae and starfish, decoct for the second time, the time is 50 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then make specification according to Chinese medicine granules, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
embodiment 5treat a Chinese medicinal granule for hiatal hernia, take off the primary raw material of stating weight proportion and be prepared from (getting 30g for every part): 12 parts of Poria cum Radix Pinis, 6 parts of Fructus Evodiaes, 12 parts of Semen Raphanis, 16 parts of Caulis Bambusae In Taenia, 5 parts, Radix Glycyrrhizae, 8 parts of black scraper Puffer, 15 parts of Cortex Magnoliae Officinalis, 4.5 parts of Concha Arcaes, 16 parts of Folium Perillaes, 9 parts of starfishes, 8 parts of Radix Scutellariaes, 9 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Semen Raphani, Cortex Magnoliae Officinalis, Concha Arcae, Radix Scutellariae, Os Sepiae are pulverized, cross 100 mesh sieves, then add 55% ethanol (ethanol consumption is 7 times of each crude drug gross weight), sealing is placed in shady and cool ventilation place and leaves standstill, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, Radix Glycyrrhizae and black scraper Puffer being placed in non iron container to add water (water consumption is 3 times of each crude drug gross weight) leaves standstill, decoct twice, decoct for the first time 50 minutes, add Folium Perillae and starfish, decoct for the second time, the time is 40 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then make specification according to Chinese medicine granules, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
experimental examplethe clinical practice of embodiment 5 gained Chinese medicinal granules: in order to verify the definite curative effect of Chinese medicinal granule of the present invention to hiatal hernia, clinical selected part patient, as observing contrast object, specifically chooses reference method as follows:
1. minor illness journey group: choosing the course of disease is that individual month of 1-3, pathology and agematched hiatal hernia 2 people A and B are a pair of contrast, contrasts altogether 80 pairs, the average recovery from illness of record natural law, efficiently individual quantity, invalid number;
2. course of disease group in: choosing the course of disease is that individual month of 4-7, pathology and agematched hiatal hernia 2 people A and B are a pair of contrast, contrasts altogether 80 pairs, the average recovery from illness of record natural law, efficiently individual quantity, invalid number;
3. severe disease journey group: choosing the course of disease is that individual month of 9-13, pathology and agematched hiatal hernia 2 people A and B are a pair of contrast, contrasts altogether 80 pairs, the average recovery from illness of record natural law, efficiently individual quantity, invalid number;
In all course of disease groups, A all uses the medicine (as the conventional medicine such as omeprazole enteric-coated capsules, losec) of conventional therapy hiatal hernia, B all uses the embodiment of the present invention 5 gained Chinese medicinal granules, adopt twice on the one, each one bag, dissolved with the warm water 200ml of 50 DEG C of left and right, before noon supper, take half an hour, 10 days courses for the treatment of.
Criterion, recovery from illness: clinical symptoms disappears completely, after breastbone, burn feeling disappears, the transference cures such as regurgitation, belch; Effective: clinical symptoms is obviously improved, partial symptoms disappears; Invalid: clinical symptoms is unchanged or increase the weight of.Result is as following table 1:
The compliance test result of table 1: embodiment 5 gained Chinese medicinal granules
Total efficiently individual quantity=efficiently individual quantity+recovery from illness number
Chinese medicinal granule of the present invention selects the medicines such as Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, black scraper Puffer, Concha Arcae, Os Sepiae to carry out compatibility, makes medicine produce synergism, can more effective treatment hiatal hernia.As can be seen from Table 1, Chinese medicinal granule of the present invention is remarkable to hiatal hernia therapeutic effect, and the average curative day of minor illness journey group is 5 days, and effective percentage is 98.8%; The average curative day of middle course of disease group is 12 days, and effective percentage is 97.5%; The average curative day of severe disease journey group is 18 days, effective percentage is 95%, no matter be average curative day, or effective percentage, curative effect is better than the effect of conventional western medicine, and effective percentage ensures more than 95%, and recovery from illness patient tracing observation is found, after not having a routine drug withdrawal, recur, therefore can prove that Chinese medicinal granule of the present invention can fundamentally treat hiatal hernia, safe and reliable.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. a Chinese medicinal granule for the treatment of hiatal hernia, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Poria cum Radix Pini 9-15 part, Fructus Evodiae 3-10 part, Semen Raphani 5-20 part, Caulis Bambusae In Taenia 10-25 part, Radix Glycyrrhizae 2-8 part, black scraper Puffer 4-12 part, Cortex Magnoliae Officinalis 10-20 part, Concha Arcae 3-6 part, Folium Perillae 12-20 part, starfish 5-13 part, Radix Scutellariae 4-12 part, Os Sepiae 6-12 part.
2. Chinese medicinal granule according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Poria cum Radix Pini 11-13 part, Fructus Evodiae 5-7 part, Semen Raphani 10-15 part, Caulis Bambusae In Taenia 12-20 part, Radix Glycyrrhizae 4-6 part, black scraper Puffer 6-10 part, Cortex Magnoliae Officinalis 13-17 part, Concha Arcae 4-5 part, Folium Perillae 14-18 part, starfish 7-11 part, Radix Scutellariae 6-10 part, Os Sepiae 8-10 part.
3. Chinese medicinal granule according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Poria cum Radix Pinis, 6 parts of Fructus Evodiaes, 12 parts of Semen Raphanis, 16 parts of Caulis Bambusae In Taenia, 5 parts, Radix Glycyrrhizae, 8 parts of black scraper Puffer, 15 parts of Cortex Magnoliae Officinalis, 4.5 parts of Concha Arcaes, 16 parts of Folium Perillaes, 9 parts of starfishes, 8 parts of Radix Scutellariaes, 9 parts of Os Sepiae.
4. according to the preparation method of the arbitrary described Chinese medicinal granule of claim 1-3, it is characterized in that, step is as follows:
(1) Semen Raphani, Cortex Magnoliae Officinalis, Concha Arcae, Radix Scutellariae, Os Sepiae are pulverized, sieved, then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Caulis Bambusae In Taenia, Radix Glycyrrhizae and black scraper Puffer are placed in non iron container, add water standing, decoct twice, after decocting for the first time, add Folium Perillae and starfish, decoct for the second time, filter twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then make specification according to Chinese medicine granules, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
5. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (1) is crossed 70-130 mesh sieve and (preferably, crossed 80-120 mesh sieve; Be more preferably, cross 100 mesh sieves).
6. the preparation method of Chinese medicinal granule according to claim 4, it is characterized in that, the consumption of step (1) ethanol be each crude drug gross weight 5-9 doubly (preferred, the consumption of ethanol be each crude drug gross weight 6-8 doubly, be more preferably, the consumption of ethanol is 7 times of each crude drug gross weight).
7. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, it is that 40%-70%(is preferred that step (1) adds the concentration of ethanol, and the concentration that adds ethanol is 50%-60%; Be more preferably, the concentration that adds ethanol is 55%).
8. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (2) water consumption be each crude drug gross weight 2-4 doubly (preferred, water consumption be each crude drug gross weight 2.5-3.5 doubly; Be more preferably, water consumption is 3 times of each crude drug gross weight).
9. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (2) decocts for the first time and (preferably, decocts for the first time 40-60 minute in 30-70 minute; Be more preferably, decoct for the first time 50 minutes).
10. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (2) decocts for the second time and (preferably, decocts for the second time 30-50 minute in 25-55 minute; Be more preferably, decoct for the second time 40 minutes).
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| CN105998708A (en) * | 2016-07-17 | 2016-10-12 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine composition for treating esophageal hiatal hernia due to stomach dryness and body fluid deficiency |
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| Title |
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| 范传玲 等: "《最新消化系统疾病诊疗与护理》", 30 September 2008 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998708A (en) * | 2016-07-17 | 2016-10-12 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine composition for treating esophageal hiatal hernia due to stomach dryness and body fluid deficiency |
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