CN104474201A - Pharmaceutical composition for treating stomach illness and preparation method thereof - Google Patents
Pharmaceutical composition for treating stomach illness and preparation method thereof Download PDFInfo
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- CN104474201A CN104474201A CN201410717363.7A CN201410717363A CN104474201A CN 104474201 A CN104474201 A CN 104474201A CN 201410717363 A CN201410717363 A CN 201410717363A CN 104474201 A CN104474201 A CN 104474201A
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Abstract
The invention relates to a pharmaceutical composition for treating stomach illness and a preparation method thereof. By extracting effective components of astragalus membranaceus, acanthopanax and hawthorn for stomach illness and concentrating and extracting the effective components and then adding stomach-nourishing and stomach-protecting medicinal powder to enhance the curative effect, the equal effect of a compound western medicine preparation for treating stomach illness can be achieved and excessively strong toxic and side effects on the human body by taking western medicines are avoided, so that the patient can grid rid of torture of stomach illness as soon as possible and is prevented from being secondarily hurt by toxic and side effects.
Description
Technical field
The present invention relates to the technical field of medicine, particularly a kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof.
Background technology
Gastropathy is a kind of common disease, nervous work, study, bad dietary habit (as irregular in excessive drinking, gluttony, monophagia and diet, edible too much excitant food), medicine irritation, bacteriological infection all may make stomach produce irritability reaction, make gastric mucosa impaired, and cause acute, the series of symptoms such as chronic gastritis, gastric ulcer, duodenal ulcer, polyp of stomach, prolapse of gastric mucosa, gastropathy also has the feature being difficult to effect a radical cure, and if things go on like this even can bring out the heavy disease such as tumor stomach, gastric cancer.
Due to the anxiety of life and the due to pressure of work, many patients with gastric disease are for asking short time visible curative effect, and take gastro-kinetic agent, containing compound recipe Western medicine preparations such as aluminium porcelain enamelling, gastric mucosa protective agent, bismuth, though this type of medicine can act on soon, the outbreak of gastropathy can be suppressed in the short time, but be difficult to effect a permanent cure, and these medicines in various degree have side effect, after being absorbed by the body, the organ-tissues such as liver,kidney,spleen, brain, skeleton can being affected and cause damage in various degree; Although use treatment by Chinese herbs gastropathy side effect degree less, exist and take effect slowly, take inconvenient feature.
Summary of the invention
The object of the invention is to: a kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof is provided, by extracting the effective ingredient of its Radix Astragali for gastropathy, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, and carry out concentration extraction, add nourishing the stomach afterwards and protect the drug powder of stomach to strengthen its therapeutic effect, the compound recipe Western medicine preparation equivalent effect with treatment gastropathy can be reached, and avoid taking Western medicine strong toxic and side effects was caused to human body, allow patient can break away from the torment of gastropathy as early as possible, and from the secondary injury of toxic and side effects.
For solving the problems of the technologies described above, the present invention takes following technical scheme:
A kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof, by following material by weight mark ratio make:
Glycosides compound 20-25 part, Rhizoma Dioscoreae 10-12 part, Radix Cynanchi Paniculati 5-7 part, Massa Medicata Fermentata 5-7 part, Radix Et Rhizoma Rhei 4-6 part, Radix Codonopsis 3-5 part, Rhizoma Atractylodis Macrocephalae 3-5 part, Radix Glycyrrhizae 3-5 part, Radix Et Rhizoma Rhei 4-6 part.
Described glycosides compound presses the weight ratio of 20-25:30-40:10-15 by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, obtained after extracting.
A kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof, comprises the following steps:
Step 1: get the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi is cleaned, dry, to mix after pulverization process, with 8-10 times amount, concentration is aquiferous ethanol reflux, extract, 2-3 time of 50%-70%, each 3-4 hour, by extracting liquid filtering, merging filtrate is evaporated to without ethanol abnormal smells from the patient, again through macroporous adsorbent resin, with the aquiferous ethanol gradient elution of the 50%-70% of 5 times of column volumes, after again carry out being evaporated to without ethanol abnormal smells from the patient, add alkaline solution afterwards, regulate pH to 9-10, add acid solution react 8-10 hour at 35-40 DEG C after and regulate pH to 6.8-7.2, add n-butanol extraction, collect organic facies and carry out chromatography through polyamide column, the aquiferous ethanol re-using 50%-70% carries out gradient elution, carrying out being evaporated to relative density is 1.2, add extraction into ethyl acetate again, collecting aqueous phase and being concentrated into relative density is 1.3, after leaving standstill, precipitation is filtered completely, after filter cake washes with water, it is being carried out recrystallization with methanol, obtain the glycosides compound that powder is above composition.
Pulverizing described in this step is pulverized and cross 20 mesh sieves at the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi.
Alkaline solution described in this step to be mass concentration be 2% sodium hydroxide or potassium hydroxide solution.
During acid solution described in this step, mass concentration is dilute sulfuric acid or the dilute hydrochloric acid of 4.
Washing with water described in this step uses deionized water to wash.
Step 2: pulverized by the material of remainder, mixs homogeneously with glycosides compound powder, obtains the pharmaceutical composition of described treatment gastropathy.
Pulverizing described in this step is that remaining crushing material is crossed 200 mesh sieves.
Preferably, those skilled in the art can according to knowledge, adds the pharmaceutically conventional medicine that pharmaceutically acceptable adjuvant or complementary composition are prepared in the present invention, as medicines such as tablet, capsule, electuary, oral liquid, drop pill.
Usefulness of the present invention is, the astragaloside in the Radix Astragali and the hyperin in Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi is together carried out combining slightly carrying, and while astragaloside, hyperin being extracted, associating is slightly carried and can be reduced unnecessary operation sequence as far as possible; Medicine that is all the other are effective to gastropathy, nourishing the stomach is pulverized and is mixed with glycosides compound simultaneously, can improve effect of glycosides compound treatment gastropathy, maintenance stomach.
Detailed description of the invention
The invention discloses a kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof, those skilled in the art can use for reference present disclosure, and appropriate reconstruction technological parameter realizes the making of this product.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are deemed to be included in the present invention.Pharmaceutical composition for the treatment of gastropathy of the present invention and preparation method thereof have passed through preferred embodiment and is described, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
If no special instructions, the test material related in a specific embodiment all freely can be buied from market.
Below in conjunction with embodiment, the present invention is specifically described:
Embodiment 1
Treat a pharmaceutical composition for gastropathy, by following material by weight mark ratio make:
Glycosides compound 20 parts, Rhizoma Dioscoreae 10 parts, Radix Cynanchi Paniculati 5 parts, Massa Medicata Fermentata 5 parts, Radix Et Rhizoma Rhei 4 parts, Radix Codonopsis 3 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, 3 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 4 parts.
Described glycosides compound presses the weight ratio of 20:30:10 by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, obtained after extracting.
A kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof, comprises the following steps:
Step 1: get the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi is cleaned, dry, to mix after pulverization process, with 8 times amount, concentration is the aquiferous ethanol reflux, extract, 2 times of 50%, each 3 hours, by extracting liquid filtering, merging filtrate is evaporated to without ethanol abnormal smells from the patient, again through macroporous adsorbent resin, with the aquiferous ethanol gradient elution of 50% of 5 times of column volumes, after again carry out being evaporated to without ethanol abnormal smells from the patient, add alkaline solution afterwards, regulate pH to 9, react at 35 DEG C after 8 hours and add acid solution adjustment pH to 6.8, add n-butanol extraction, collect organic facies and carry out chromatography through polyamide column, the aquiferous ethanol re-using 50% carries out gradient elution, carrying out being evaporated to relative density is 1.2, add extraction into ethyl acetate again, collecting aqueous phase and being concentrated into relative density is 1.3, after leaving standstill, precipitation is filtered completely, after filter cake washes with water, it is being carried out recrystallization with methanol, obtain the glycosides compound that powder is above composition.
Pulverizing described in this step is pulverized and cross 20 mesh sieves at the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi.
Alkaline solution described in this step to be mass concentration be 2% sodium hydroxide or potassium hydroxide solution.
During acid solution described in this step, mass concentration is dilute sulfuric acid or the dilute hydrochloric acid of 4.
Washing with water described in this step uses deionized water to wash.
Step 2: pulverized by the material of remainder, mixs homogeneously with glycosides compound powder, obtains the pharmaceutical composition of described treatment gastropathy.
Pulverizing described in this step is that remaining crushing material is crossed 200 mesh sieves.
Preferably, those skilled in the art can according to knowledge, adds the pharmaceutically conventional medicine that pharmaceutically acceptable adjuvant or complementary composition are prepared in the present invention, as medicines such as tablet, capsule, electuary, oral liquid, drop pill.
Embodiment 2
Treat a pharmaceutical composition for gastropathy, by following material by weight mark ratio make:
Glycosides compound 23 parts, Rhizoma Dioscoreae 11 parts, Radix Cynanchi Paniculati 6 parts, Massa Medicata Fermentata 6 parts, Radix Et Rhizoma Rhei 5 parts, Radix Codonopsis 4 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, 4 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 5 parts.
Described glycosides compound presses the weight ratio of 23:35:13 by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, obtained after extracting.
A kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof, comprises the following steps:
Step 1: get the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi is cleaned, dry, to mix after pulverization process, with 9 times amount, concentration is the aquiferous ethanol reflux, extract, 3 times of 60%, each 3.5 hours, by extracting liquid filtering, merging filtrate is evaporated to without ethanol abnormal smells from the patient, again through macroporous adsorbent resin, with the aquiferous ethanol gradient elution of 60% of 5 times of column volumes, after again carry out being evaporated to without ethanol abnormal smells from the patient, add alkaline solution afterwards, regulate pH to 9.5, react at 38 DEG C after 9 hours and add acid solution adjustment pH to 7, add n-butanol extraction, collect organic facies and carry out chromatography through polyamide column, the aquiferous ethanol re-using 60% carries out gradient elution, carrying out being evaporated to relative density is 1.2, add extraction into ethyl acetate again, collecting aqueous phase and being concentrated into relative density is 1.3, after leaving standstill, precipitation is filtered completely, after filter cake washes with water, it is being carried out recrystallization with methanol, obtain the glycosides compound that powder is above composition.
Pulverizing described in this step is pulverized and cross 20 mesh sieves at the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi.
Alkaline solution described in this step to be mass concentration be 2% sodium hydroxide or potassium hydroxide solution.
During acid solution described in this step, mass concentration is dilute sulfuric acid or the dilute hydrochloric acid of 4.
Washing with water described in this step uses deionized water to wash.
Step 2: pulverized by the material of remainder, mixs homogeneously with glycosides compound powder, obtains the pharmaceutical composition of described treatment gastropathy.
Pulverizing described in this step is that remaining crushing material is crossed 200 mesh sieves.
Preferably, those skilled in the art can according to knowledge, adds the pharmaceutically conventional medicine that pharmaceutically acceptable adjuvant or complementary composition are prepared in the present invention, as medicines such as tablet, capsule, electuary, oral liquid, drop pill.
Embodiment 3
A kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof, by following material by weight mark ratio make:
Glycosides compound 25 parts, Rhizoma Dioscoreae 12 parts, Radix Cynanchi Paniculati 7 parts, Massa Medicata Fermentata 7 parts, Radix Et Rhizoma Rhei 6 parts, Radix Codonopsis 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 5 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 6 parts.
Described glycosides compound presses the weight ratio of 25:40:15 by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, obtained after extracting.
A kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof, comprises the following steps:
Step 1: get the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi is cleaned, dry, to mix after pulverization process, with 10 times amount, concentration is the aquiferous ethanol reflux, extract, 3 times of 70%, each 4 hours, by extracting liquid filtering, merging filtrate is evaporated to without ethanol abnormal smells from the patient, again through macroporous adsorbent resin, with the aquiferous ethanol gradient elution of 70% of 5 times of column volumes, after again carry out being evaporated to without ethanol abnormal smells from the patient, add alkaline solution afterwards, regulate pH to 9-10, react at 40 DEG C after 10 hours and add acid solution adjustment pH to 7.2, add n-butanol extraction, collect organic facies and carry out chromatography through polyamide column, the aquiferous ethanol re-using 70% carries out gradient elution, carrying out being evaporated to relative density is 1.2, add extraction into ethyl acetate again, collecting aqueous phase and being concentrated into relative density is 1.3, after leaving standstill, precipitation is filtered completely, after filter cake washes with water, it is being carried out recrystallization with methanol, obtain the glycosides compound that powder is above composition.
Pulverizing described in this step is pulverized and cross 20 mesh sieves at the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi.
Alkaline solution described in this step to be mass concentration be 2% sodium hydroxide or potassium hydroxide solution.
During acid solution described in this step, mass concentration is dilute sulfuric acid or the dilute hydrochloric acid of 4.
Washing with water described in this step uses deionized water to wash.
Step 2: pulverized by the material of remainder, mixs homogeneously with glycosides compound powder, obtains the pharmaceutical composition of described treatment gastropathy.
Pulverizing described in this step is that remaining crushing material is crossed 200 mesh sieves.
Preferably, those skilled in the art can according to knowledge, adds the pharmaceutically conventional medicine that pharmaceutically acceptable adjuvant or complementary composition are prepared in the present invention, as medicines such as tablet, capsule, electuary, oral liquid, drop pill.
Test case
Use mice as the test animal of this test case, mice 200 is selected only to carry out early-stage preparations, the conventional food of food as mice of helicobacter pylori will be mixed with, mice ate this food after 12 weeks, its appetite declines more than half, the mice selecting appetite wherein comparatively close 100, be divided into 5 groups, respectively the compound recipe Western medicine stomach medicine of each for this product embodiment and two commercial type is mixed in the food of mice, carry out contrast test, in test, section feeds mice enough equal food 5 times at one time every day, every 4 hours one time, collect group mice amount every day, continue to carry out preliminary simple evaluation and test to mice appetite to this product after 4 weeks.
Test case 1
Mice was first week testing period, and appetite increases gradually, and second week to start appetite mid-term and recovers normal, and before within the 3rd week, starting appetite and early-stage preparations, appetite is fair increases even to some extent, 4th week maintenance the 3rd week appetite level.
Test case 2
Mice was first week testing period, and appetite increases gradually, and second week starts appetite and recovers normal, and before second week starts appetite and early-stage preparations weekend, appetite maintains an equal level increases, even to some extent until 4th week maintenance second week appetite at weekend level.
Test case 3
Mice was first week testing period, and appetite increases gradually, and second week starts appetite and recovers normal, and before second week starts appetite and early-stage preparations weekend, appetite maintains an equal level increases, even to some extent until 4th week maintenance second week appetite at weekend level.
Compound recipe western medicine group 1
Mice was first week testing period, and appetite increases gradually, and second week starts appetite and recovers normal, and before the 3rd week starts appetite and early-stage preparations, appetite maintains an equal level increases even to some extent, and 4th week keeps the 3rd week appetite level.
Compound recipe western medicine group 2
Mice was first week testing period, and appetite increases gradually, and second week to start appetite mid-term and recovers normal, and before second week appetite at weekend and early-stage preparations, appetite maintains an equal level increases, even to some extent until 4th week maintenance second week appetite at weekend level.
The above; be only the specific embodiment of the present invention; but protection scope of the present invention is not limited thereto; any those of ordinary skill in the art are in the technical scope disclosed by the present invention; the change can expected without creative work or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should limit with claims is as the criterion.
Claims (3)
1. pharmaceutical composition for the treatment of gastropathy and preparation method thereof, it is characterized in that by following material by weight mark ratio make:
Glycosides compound 20-25 part, Rhizoma Dioscoreae 10-12 part, Radix Cynanchi Paniculati 5-7 part, Massa Medicata Fermentata 5-7 part, Radix Et Rhizoma Rhei 4-6 part, Radix Codonopsis 3-5 part, Rhizoma Atractylodis Macrocephalae 3-5 part, Radix Glycyrrhizae 3-5 part, Radix Et Rhizoma Rhei 4-6 part; It is characterized in that, described glycosides compound presses the weight ratio of 20-25:30-40:10-15 by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, obtained after extracting.
2. pharmaceutical composition for the treatment of gastropathy and preparation method thereof, is characterized in that following steps:
Step 1: get the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi is cleaned, dry, to mix after pulverization process, with 8-10 times amount, concentration is aquiferous ethanol reflux, extract, 2-3 time of 50%-70%, each 3-4 hour, by extracting liquid filtering, merging filtrate is evaporated to without ethanol abnormal smells from the patient, again through macroporous adsorbent resin, with the aquiferous ethanol gradient elution of the 50%-70% of 5 times of column volumes, after again carry out being evaporated to without ethanol abnormal smells from the patient, add alkaline solution afterwards, regulate pH to 9-10, add acid solution react 8-10 hour at 35-40 DEG C after and regulate pH to 6.8-7.2, add n-butanol extraction, collect organic facies and carry out chromatography through polyamide column, the aquiferous ethanol re-using 50%-70% carries out gradient elution, carrying out being evaporated to relative density is 1.2, add extraction into ethyl acetate again, collecting aqueous phase and being concentrated into relative density is 1.3, after leaving standstill, precipitation is filtered completely, after filter cake washes with water, it is being carried out recrystallization with methanol, obtain the glycosides compound that powder is above composition, pulverizing described in this step is pulverized and cross 20 mesh sieves at the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, alkaline solution described in this step to be mass concentration be 2% sodium hydroxide or potassium hydroxide solution, during acid solution described in this step, mass concentration is dilute sulfuric acid or the dilute hydrochloric acid of 4, washing with water described in this step uses deionized water to wash, step 2: pulverized by the material of remainder, mixs homogeneously with glycosides compound powder, obtains the pharmaceutical composition of described treatment gastropathy, pulverizing described in this step is that remaining crushing material is crossed 200 mesh sieves.
3. a kind of pharmaceutical composition for the treatment of gastropathy and preparation method thereof as claimed in claim 2, it is characterized in that: the pharmaceutically conventional medicine that pharmaceutically acceptable adjuvant or complementary composition are prepared into can be added in described compositions, as medicines such as tablet, capsule, electuary, oral liquid, drop pill.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410717363.7A CN104474201A (en) | 2014-12-02 | 2014-12-02 | Pharmaceutical composition for treating stomach illness and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410717363.7A CN104474201A (en) | 2014-12-02 | 2014-12-02 | Pharmaceutical composition for treating stomach illness and preparation method thereof |
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| CN104474201A true CN104474201A (en) | 2015-04-01 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856412A (en) * | 2009-04-09 | 2010-10-13 | 刘君峰 | Chinese medicament for treating gastroptosis |
| CN102641454A (en) * | 2012-05-22 | 2012-08-22 | 江苏省中医药研究院 | Traditional Chinese medicine composition for treating chronic atrophic gastritis |
| CN102698175A (en) * | 2012-03-20 | 2012-10-03 | 章崇芝 | Traditional Chinese medicinal composition for treating gastroptosis |
-
2014
- 2014-12-02 CN CN201410717363.7A patent/CN104474201A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856412A (en) * | 2009-04-09 | 2010-10-13 | 刘君峰 | Chinese medicament for treating gastroptosis |
| CN102698175A (en) * | 2012-03-20 | 2012-10-03 | 章崇芝 | Traditional Chinese medicinal composition for treating gastroptosis |
| CN102641454A (en) * | 2012-05-22 | 2012-08-22 | 江苏省中医药研究院 | Traditional Chinese medicine composition for treating chronic atrophic gastritis |
Non-Patent Citations (6)
| Title |
|---|
| 张长庆等: "慢性胃病中医三层次辨证用药探讨", 《四川中医》 * |
| 王来法: "《标本兼治看胃病——30年诊疗经验》", 30 July 2013 * |
| 赵余庆: "《中药及天然产物提取制备关键技术》", 31 January 2012 * |
| 郝中珍: "胃复汤治疗慢性萎缩性胃炎68例", 《河北中医》 * |
| 陈月波: "辨证治疗萎缩性胃炎", 《中医杂志》 * |
| 龚超: "辨证治疗萎缩性胃炎", 《湖北中医杂志》 * |
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Application publication date: 20150401 |