CN104471393B - 用于检测微小残留病的方法、试剂以及试剂盒 - Google Patents

用于检测微小残留病的方法、试剂以及试剂盒 Download PDF

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CN104471393B
CN104471393B CN201380037624.4A CN201380037624A CN104471393B CN 104471393 B CN104471393 B CN 104471393B CN 201380037624 A CN201380037624 A CN 201380037624A CN 104471393 B CN104471393 B CN 104471393B
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CN104471393A (zh
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雅各布斯·约翰内斯·玛丽亚·万东恩
何塞·阿尔贝托·奥尔方德马托斯克瑞亚埃韦尔
朱安·亚历杭德罗·弗洛雷斯蒙特罗
茱莉亚·玛丽亚·阿尔梅达帕拉
文森特·亨利库斯·约翰内斯·万德费尔登
塞巴斯蒂安·博埃特赫尔
朗托尼·威廉·朗格拉克
埃斯特尔·迈斯特日科娃
托马斯·什切潘斯基
马蒂亚斯·里特根
保罗·约根·蒙泰罗达席尔瓦卢西奥
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Erasmus University Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1716—Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201380037624.4A 2012-06-14 2013-06-14 用于检测微小残留病的方法、试剂以及试剂盒 Active CN104471393B (zh)

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US20150160226A1 (en) 2012-06-14 2015-06-11 Erasmus University Medical Center Rotterdam Method, reagents, and kits for detecting minimal residual disease
WO2015160226A1 (ko) * 2014-04-17 2015-10-22 주식회사 건강사랑 레드클로버 및 석류의 복합 추출물을 유효성분으로 포함하는 조성물의 여성 갱년기 개선 용도
WO2017027391A2 (en) * 2015-08-07 2017-02-16 Dana-Farber Cancer Institute, Inc. Genetic abnormalities in plasma cell dyscrasias
CN105223360B (zh) * 2015-08-28 2017-03-22 北京大学人民医院 鉴别检测正常浆细胞和克隆性浆细胞的试剂盒及其应用
CN106290812A (zh) * 2016-09-08 2017-01-04 北京海思特临床检验所有限公司 B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法
JP7084695B2 (ja) * 2017-03-28 2022-06-15 シスメックス株式会社 試薬選択支援装置、方法、プログラムおよび記録媒体並びに試料測定装置
CN108458964A (zh) * 2017-10-31 2018-08-28 天津协和华美医学诊断技术有限公司 一种抗体组合物及其在淋巴浆细胞性淋巴瘤微小残留检测中的应用
AU2019265019B2 (en) 2018-05-11 2025-11-06 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
CN109655616B (zh) * 2018-12-19 2022-05-06 广州金域医学检验中心有限公司 检测急性髓系白血病细胞的组合试剂及系统
CN109752548B (zh) * 2019-02-01 2022-05-06 广州金域医学检验中心有限公司 评估慢性淋巴细胞白血病预后的组合试剂及系统
CN109884313A (zh) * 2019-02-22 2019-06-14 武汉康圣达医学检验所有限公司 急性b淋巴细胞白血病微小残留的检测试剂盒
EP4110351A4 (en) 2020-02-25 2024-07-03 Seema Singhal Liquid biopsy yield enhancement
CN114487422A (zh) * 2020-10-26 2022-05-13 苏州云泰生物医药科技有限公司 用于监测急性b淋巴细胞白血病微小残留病灶的流式细胞术试剂盒及监测方法
CN112578117B (zh) * 2021-02-22 2021-05-25 信纳克(北京)生化标志物检测医学研究有限责任公司 抗体组合物及其筛查移植后淋巴细胞增殖性疾病的应用
CN112552407B (zh) * 2021-02-24 2021-05-25 信纳克(北京)生化标志物检测医学研究有限责任公司 抗体组合物及其在检测急性b淋巴细胞白血病中的应用
CN112698037B (zh) * 2021-03-25 2021-06-25 北京积水潭医院 一种检测多发性骨髓瘤治疗效果的抗体组合物及其试剂盒和应用
CN113419066B (zh) 2021-08-23 2021-11-02 信纳克(北京)生化标志物检测医学研究有限责任公司 一步法筛查和/或诊断克隆性疾病的试剂组合物及其应用
CN113777327B (zh) * 2021-09-13 2022-09-02 北京大学人民医院 用于白血病/淋巴瘤免疫分型初筛的抗体组合物及其应用
CN113933511B (zh) * 2021-09-18 2024-03-22 广州金域医学检验中心有限公司 检测急性b淋巴细胞白血病微小残留的抗体组合物及方法
CN115197322B (zh) * 2022-07-21 2024-01-30 江苏省人民医院（南京医科大学第一附属医院） 用于慢性淋巴细胞白血病微小残留病灶检测的抗体组合物及其应用
CN115491423A (zh) * 2022-09-23 2022-12-20 珠海横琴铂华医学检验有限公司 一种用于b细胞淋巴瘤mrd监测的基因组合、试剂盒与应用
CN116087518B (zh) * 2022-11-02 2025-01-07 北京海思特医学检验实验室有限公司 一种mrd检测产品
CN115902216B (zh) * 2022-12-22 2025-03-18 苏州元德维康生物科技有限公司 筛查和/或诊断浆细胞肿瘤的试剂组合物及其应用
CN115856302B (zh) * 2023-03-02 2023-06-02 北京大学人民医院 用于成熟b细胞肿瘤免疫分型的抗体组合物及其应用
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BG113932A (bg) 2024-07-19 2026-01-30 Медицински университет – Пловдив Панели и китове от реагенти за измерване на минимална резидуална болест при детска в-клетъчна прекурсорна остра лимфобластна левкемия чрез имунофенотипизация

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Publication number Publication date
US20180140664A1 (en) 2018-05-24
WO2013187765A2 (en) 2013-12-19
US20210177936A1 (en) 2021-06-17
EP2861987A2 (en) 2015-04-22
AU2013274965B2 (en) 2018-07-19
CA2876405A1 (en) 2013-12-19
CN107422122A (zh) 2017-12-01
JP6524197B2 (ja) 2019-06-05
WO2013187765A3 (en) 2014-04-24
EP2861987B1 (en) 2016-04-27
CN104471393A (zh) 2015-03-25
CN107422122B (zh) 2020-06-26
JP6262218B2 (ja) 2018-01-17
AU2013274965A1 (en) 2015-01-22
AU2018204429B2 (en) 2020-04-02
CA3022975A1 (en) 2013-12-19
US20150160226A1 (en) 2015-06-11
CA3022975C (en) 2019-10-01
EP3064942A3 (en) 2016-10-19
DK2861987T3 (en) 2016-07-04
JP2015521733A (ja) 2015-07-30
DK3064942T3 (en) 2018-03-05
US10874710B2 (en) 2020-12-29
US11571457B2 (en) 2023-02-07
CA2876405C (en) 2020-01-07
EP3064942B1 (en) 2017-12-20
EP3064942A2 (en) 2016-09-07
ES2660429T3 (es) 2018-03-22
JP2018066752A (ja) 2018-04-26
AU2018204429A1 (en) 2018-07-05

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