CN104435707A

CN104435707A - Pericarpium granati traditional Chinese medicine tea for prolonged diarrhea and dysentery and hemafecia and preparation method of pericarpium granati traditional Chinese medicine tea

Info

Publication number: CN104435707A
Application number: CN201410655356.9A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2014-11-17
Filing date: 2014-11-17
Publication date: 2015-03-25

Abstract

The invention provides a pericarpium granati traditional Chinese medicine tea for prolonged diarrhea and dysentery and hemafecia. The traditional Chinese medicine tea is prepared from the following raw materials in parts by weight: 10-50 parts of pericarpium granati, 10-20 parts of portulaca oleracea, 10-20 parts of pagoda tree pod, 10-20 parts of sealwort, 10-20 parts of allium macrostemon, 10-20 parts of poria cocos, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of root of Chinese pulsatilla, 10-20 parts of rhizoma atractylodis and 10-20 parts of scutellaria baicalensis. The pericarpium granati traditional Chinese medicine tea is mainly used for diminishing inflammation and purging intense heat in the Western medicine aiming at prolonged diarrhea and dysentery and hemafecia; antibiotics are relatively large in harm to a human body, and are easily repeated; and the best treatment mode at present is a method for conditioning by using the traditional Chinese medicine. In the treatment process, the traditional Chinese medicine acts appropriately to the situation; one prescription is suitable for a person; the patent also needs to be on a diet; the traditional Chinese medicine is bitter in smell, poor in taste, laborious in decoction, and inconvenient to take for a long period of time; the pericarpium granati traditional Chinese medicine tea is convenient to carry, simple to use, and suitable for being taken for a long period of time, does not generate the drug resistance and dependence, is capable of improving microcirculation, and is easy to accept by people, and suitable for being drunk by people who want to reduce diarrhea and the pain of prolonged diarrhea and dysentery and hemafecia, do not need to be on a diet and do not like the bitter smell of the traditional Chinese medicine.

Description

A kind of for chronic diarrhea chronic dysentery, the Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool and preparation method thereof

Technical field

The present invention relates to the Chinese medicinal healthcare tea containing deriving from plant composition, particularly a kind of for chronic diarrhea chronic dysentery, the Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool and preparation method thereof.

Background technology

Modern's dietary structure is too meticulous, easily occurs repeatability, multiple chronic diarrhea and dysentery.Symptom is left lower quadrant pain, diarrhoea, tenesmus, time be just stained with down liquid, constipation or have loose bowels alternately occur, fashion time bad, touching lower disconnected, recurrent exerbation.

One, intolerance factors: anaphylaxis pathological changes, affects by individual variation.Mainly intestinal is irritated, has and involve skin time also.Some people produces irritated to the high protein diet such as Fish, shrimp, Eriocheir sinensis, Lac Bovis seu Bubali, these are all foreign protein a large amount of histamines materials that produces when entering human body, initiation anaphylactic reaction.Anaphylactic reaction, be stimulate by sensitizer, autoimmune induces reaction, and discharges self-defence material and excites a large amount of immunocyte to condense, all concentrates on gastrointestinal mucosal surface, thus causes the inflammation such as the congested and sepage of mucomembranous surface edema to occur.Anaphylactic reaction is the change along with human lives, dietary habit, individual difference, is the principal element of digestion allergy.

Two, infective agent: infect, be one of Etiological in the colitis cause of disease.Although fail to examine pathogenic bacterium, virus or fungus in feces.Whenever falling ill, use antibiotic then to have and control the state of an illness and therapeutic effect in various degree, this illustrates that antibiotic has and suppresses escherichia coli and other pathogenic bacterium, can lower clinical symptoms, it is generally acknowledged all relevant with infection.The mankind are heterophagous, not tying or rotten food, often intestinal pathological changes occurring when having eaten, and are account for colitis cause of disease majority.

Three, autoimmune: along with social development, the progress of medical science, immunologic Fast Growth, have a lot of not clear cause of disease all to verify.At present, the sickness rate of immune disease is high, and treatment difficulty, draws attention.Therefore, chronic colitis is difficult to cure under conventional therapy is.

Patient often has the symptoms such as diarrhoea, stomachache, abdominal distention, dyspepsia.Chinese medicine is thought " diarrhoea " belongs to " chronic diarrhea " category, mainly due to insufficiency of the spleen and lose caused by normal transportation capabilities.If one is in a bad mood the fluctuation person that namely needs defecation, be " hyperactive liver-QI attacking the spleen "; And the person that all needs defecation early morning every day, be then " asthenia of both the spleen and kidney ".Treatment needs the method taking warm spleen invigorating sun, soothing liver and strengthening spleen and warming and recuperating the spleen and kidney respectively, helps with relieving diarrhea with astringents medicine, treating both the principal and secondary aspects of a disease, often can obtain good curative effect.But over the course for the treatment of, patient also needs " dieting ".Because the raising of " dieting " and therapeutic effect and consolidate close relation, though otherwise medicine suit the medicine to the illness, therapeutic effect is not good, even makes a futile effort; Or be improved, see Relapse rate again, so that all that has been achieved is spoiled.

Due to the change of dietary habit, hypertension between twenty and fifty at present, diabetes and hyperlipidemia sickness rate are in rising trend, therefore the rejuvenation of hemorrhagic colitis patient is the problem that can not be ignored, and should give attention clinically.This research shows, and with age, polyp of colon, rectum and colon cancer, diverticulum and angiodysplasia cause the incidence rate of having blood in stool to show a rising trend, and UC is on a declining curve, and this and UC are apt to occur between twenty and fifty relevant.And rectum and colitis, internal hemorrhoid cause the incidence rate of having blood in stool uncorrelated with the age, its reason is that inflammation and internal hemorrhoid all can occur at each age group.Digestive tract hemorrhage, per anum is discharged, comprise have blood in stool merely, bleeding after defecation, rectal bleeding followed by defecation, have blood in stool assorted under, or just in hold blood under the arm.Blood is discharged from anus, stool band blood, or is hemafecia entirely, and color is scarlet, dark red or pitch sample, is all called and has blood in stool.

Have blood in stool and generally see lower digestive tract hemorrhage, particularly colon and rectum is hemorrhage, but visible upper gastrointestinal hemorrhage once in a while.Have blood in stool with skin, cat film or other organ hemorrhages phenomenon person, be more common in disease in the blood system and other systemic diseases.Having blood in stool is one of the cardinal symptom of digestive tract disease.One is the disease of intestinal itself, such as intestinal ulcer and inflammation, parasitic infection, tumor, hemorrhoid, intussusception, anal fissure, scratch etc. of being hard and dry.Two is the diseases of other system beyond intestinal, such as hematopathy, acute infectious disease, avitaminosis, poisoning or dealed with medicine went etc.

Pericarpium Granati, sour in the mouth, puckery, warm in nature, return large intestine, kidney channel, have the effect of convergence astringing intestine to stop diarrhea, be applicable to chronic diarrhea, chronic dysentery, have blood in stool and the card such as proctoptosis.Compendium of Material Medica says that it can " antidiarrheal dysentery hematochezia, proctoptosis, metrorrhagia, leukorrhagia." " Prescriptions for Universal Relief " " control chronic dysentery not to be recovered, Chen Shiliu dries, and is smalls, under rice water is adjusted." report according to pharmacology; Pericarpium Granati Main Ingredients and Appearance is tannin; separately have a small amount of alkaloid; staphylococcus aureus, Hemolytic streptococcus, vibrio cholera, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, Bacillus proteus, escherichia coli, bacillus pyocyaneus and tubercule bacillus are had to obvious inhibitory action and antiviral, drive the effect such as silk ribbon, ascarid; but it has certain toxicity and constipating effect; and namely dysentery should withdraw after stopping.Pericarpium Granati astringing intestine to stop diarrhea, hemostasis, anthelmintic.Control chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies." not Lu " carries it: " treat dysentery, leak-stopping essence." " property of medicine opinion ": " controls muscles and bones wind, and waist foot is unsuccessful, the anxious pain of walking contraction.Main astringing intestine to stop diarrhea, only red white dysentery.Under extracting juice stops order tear, control Lou essence." supplement to the Herbal: " main ascarid.Decoction." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls with the passing of time watery diarrhea, simmering clothes, controlling again dysentery pus and blood, large intestine hematochezia with frying Saccharum Sinensis Roxb.." " is decocted with Fructus Aristolochiae and is controlled children's's infantile malnutrition worm." " detailed outline ": " antidiarrheal dysentery, hematochezia, proctoptosis, metrorrhagia leukorrhagia.″

Experiment in vitro shows: Pericarpium Granati all has inhibitory action to 7 kinds of Grain-negative enteral pathogenic bacterium such as escherichia coli, bacterium sonnei, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera.In vitro, Pericarpium Granati decoct all has antibacterial action to 4 kinds of dysentery bacteriums, but difference to some extent in degree, with to shigella effect the strongest (1: 320), Amur, bacterium flexneri are taken second place (1: 80), and to bacterium sonnei effect poor (1: 20).The antibacterial effect of flat band method is lower than test tube method.Its antibacterial action mechanism is relevant with volume tannic acid contained by it.

In addition, Pericarpium Granati also has inhibitory action to a certain degree to Bacillus tuberculosis in vitro.The water decoction (1: 4) of Pericarpium Granati, in vitro to trichophyton, Trichophyton concentricunm, trichophyton gypseum, permitted the dermatophytess such as blue achorion, Du's big belly microspore tinea bacterium difficult to understand, rust microspore tinea bacterium, ulotrichy microspore tinea bacterium, Gypsum Fibrosum sample microspore tinea bacterium, epidermophyton inguinale, epidermophyton rubrum, Kaufman-Wolf epidermophyton, star-shaped nocardia and all had inhibitory action in various degree.

Experiment proves: Pericarpium Granati still has antivirus action, first medicinal liquid is injected chick embryo allantoic cavity, PR8 strain of influenza virus type A influenza virus is inoculated after half an hour, or first virus inoculation injectable drug again, hatch after 48 hours and carry out hemagglutination test again, prove that Pericarpium Granati decoct is diluted to 1: 10000 ~ 1: 100000 and still has the effect suppressing influenza virus.This effect also may be relevant with tannin a large amount of contained by it.

Along with industrialized development, the change of dietary structure, the improvement of living condition, have a liking for spicy, and diarrhoea, chronic dysentery have been had blood in stool sick into city; Mostly recurrent exerbation, touching difficulty more, affects quality of life.Though most patient seeks medical advice in many ways, general all poor effect, cause anxiety, depression, and then further increase the weight of the state of an illness, have a strong impact on work and quality of life.For chronic diarrhea chronic dysentery, have blood in stool, and doctor trained in Western medicine general antiinflammatory pathogenic fire purging is main, antibiotic is larger to human injury, and easily repeatedly.Therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.But over the course for the treatment of, Chinese medicine is suited the remedy to the case, people one side, patient also needs " dieting ".Because the raising of " dieting " and therapeutic effect and consolidate close relation, though otherwise medicine suit the medicine to the illness, therapeutic effect is not good, even makes a futile effort; Or be improved, see Relapse rate again, so that all that has been achieved is spoiled; And Chinese medicine odor is poor, mouthfeel is not good, boils hard, inconvenience and takes for a long time.The Chinese medicinal healthcare tea being convenient to use every day is just shown one's talent.Become market new lover.

Summary of the invention

Technical problem to be solved by this invention is, for chronic diarrhea chronic dysentery, have blood in stool, and doctor trained in Western medicine general antiinflammatory pathogenic fire purging is main, antibiotic is larger to human injury, and easily repeatedly.Therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.Over the course for the treatment of, Chinese medicine is suited the remedy to the case, and people one side, patient also needs " dieting ".Because the raising of " dieting " and therapeutic effect and consolidate close relation, though otherwise medicine suit the medicine to the illness, therapeutic effect is not good, even makes a futile effort; Or be improved, see Relapse rate again, so that all that has been achieved is spoiled; And Chinese medicine odor is poor, mouthfeel is not good, boils hard, inconvenience and takes for a long time.The Chinese medicinal healthcare tea being convenient to use every day is just shown one's talent.Become market new lover.

For solving above-mentioned technical barrier, the invention provides a kind of for chronic diarrhea chronic dysentery, the Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, the parts by weight of the various raw materials of Tea containing traditional Chinese medicine described in it can be: Pericarpium Granati 10 ~ 50 parts, Herba Portulacae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Bulbus Allii Macrostemonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, the Radix Pulsatillae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts.

Described a kind of for chronic diarrhea chronic dysentery, the Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, the parts by weight of the various raw materials of Tea containing traditional Chinese medicine described in it can also be: Pericarpium Granati 10 ~ 30 parts, Herba Portulacae 10 ~ 15 parts, the Fructus Sophorae 10 ~ 15 parts, Rhizoma Polygonati 10 ~ 15 parts, Bulbus Allii Macrostemonis 10 ~ 15 parts, 10 ~ 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, the Radix Pulsatillae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts.

Described a kind of for chronic diarrhea chronic dysentery, the Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, the parts by weight of the various raw materials of Tea containing traditional Chinese medicine described in it also can be: Pericarpium Granati 10 ~ 40 parts, Herba Portulacae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Bulbus Allii Macrostemonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, the Radix Pulsatillae 10 ~ 15 parts, Rhizoma Atractylodis 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts

For solving the problems of the technologies described above, the present invention also provides a kind of for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, and described in it, the preparation process of Tea containing traditional Chinese medicine comprises following aspect:

A. the preparation of Pericarpium Granati;

B. by other raw material pulverizing described, immersion, heating, reflux, extract, 2 times;

C. again the medicinal liquid that other raw materials extract is put into concentrator to concentrate; Add Mel or dextrin makes granule, powder or unguentum;

D. concentrated granule, powder or unguentum are mixed with the Pericarpium Granati prepared, be prepared into Tea containing traditional Chinese medicine.

In described step a, Pericarpium Granati of can gathering when Punica granatum L. goes on the market, is cut into the slice of 2-4cm after being cleaned, and shines to seven, most probably dry, puts aeration-drying place, mothproof.

In described step b, by all the other crude drug roguings, can dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add the water of other crude drug gross weight 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of other crude drug gross weight 5-7 times amount, decocts 1 ~ 1.5 hour, gets twice decocting liquid mixing, filters; Put into concentrator.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, and be concentrated into every 1ml containing 1g crude drug amount, convection drying powdered, adds Mel or dextrin makes granule, powder or unguentum.

In described steps d, the powder Pericarpium Granati prepared and surplus stock can prepared or granule mix, and ultraviolet disinfection is packed and be get final product.

For solving the problems of the technologies described above, the present invention also provides a kind of for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, and when unguentum made by other raw materials of Tea containing traditional Chinese medicine described in it, step can also be:

A, get other raw materials and put into ethanol and soak, heat is carried, and is component 1;

B, by medicinal residues extracting in water 2 times, thickening filtration is component 2;

C, by 2-in-1 and concentrated to component 1 and component; Lixiviate.

In described step a, all the other crude drug can be got, steep in the ethanol of other crude drug gross weight 5-10 times amount; Soak 1-2 hour, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; For component 1; In described step b, filtering residue can be added water, boil 45 minutes at every turn, filter, filtrate is for subsequent use, is component 2; In described step c, the filtrate of extracted twice be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into extractum.

The technique effect that the present invention is useful is: for chronic diarrhea chronic dysentery, have blood in stool, and doctor trained in Western medicine general antiinflammatory pathogenic fire purging is main, antibiotic is larger to human injury, and easily repeatedly.Therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.But over the course for the treatment of, Chinese medicine is suited the remedy to the case, people one side, patient also needs " dieting ".Because the raising of " dieting " and therapeutic effect and consolidate close relation, though otherwise medicine suit the medicine to the illness, therapeutic effect is not good, even makes a futile effort; Or be improved, see Relapse rate again, so that all that has been achieved is spoiled; And Chinese medicine odor is poor, mouthfeel is not good, boils hard, inconvenience and takes for a long time.The Chinese medicinal healthcare tea being convenient to use every day is just shown one's talent.The present invention is easy to carry, uses simple, is applicable to long-term taking, does not develop immunity to drugs and dependency, become market new lover.Soup color of the present invention is dark green, delicate fragrance long times of aftertaste, micro-bitter glycol; Add some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can microcirculation be improved, make people be easy to accept.Be applicable to both want to reduce diarrhoea, the misery of reduce chronic diarrhea chronic dysentery, having blood in stool, need not aviod certain food again, not like the drunk by people of Chinese medicine odor poverty.

Detailed description of the invention

The peel of Pericarpium Granati contains tannin 10.4%, wax 0.8%, resin fat 4.5%, mannitol 1.8%, phlegmatic temperament 0.6%, gallic acid 4.0%, malic acid, pectin and calcium oxalate 4.0%, natural gum 3.2%, inulin 1.0%, non-crystallizable sugars 2.7%.Get from tannin: Pericarpium Granati bitter principle A, B, Tannin in Punica granatum L, 2,3-O-connects two Galla Turcica (Galla Helepensis) acyl Tannin in Punica granatum Ls.Peel also contains elaidic acid, Isoquercitrin, cyanidin-3-glycoside, cyanidin-3,5-glucosulfone, stricture of vagina India element-3-glycoside of crowing, stricture of vagina India element-3,5-glucosulfones of crowing.From the methanolic extract of peel, get again four poly-gallic acids, have the activity suppressing carbonic acid dehydrogenase.

Peel, peel of stem, bark, all containing alkaloid, are isolated: 2-acetonylpiperidine, isopelletierine, pseudo-2-acetonylpiperidine, N-methylisopelletierine etc.Isolate from tannin contained by bark again: Tannin in Punica granatum L; 2; 3-O-connects two Galla Turcica (Galla Helepensis) acyl Tannin in Punica granatum Ls, 2-0-Galla Turcica (Galla Helepensis) acyl-4, and benzoaric acid connects two Galla Turcica (Galla Helepensis) acyl-D-Glucoses; 2; 3-hexahydroxy biphenyl diformyl-D-Glucose, long A, B, C, D, Pericarpium Granati gluconic acid; Casuarina equisetifolia L. tannin, Casuarina equisetifolia L. is tanned rather.

The multiple antibacterial action of Pericarpium Granati: treatment bacillary dysentery: getting Pericarpium Granati and make 50% or 60% decoct, each 10 ~ 20 milliliters, take 3 ~ 4 day, 7 ~ 10 days is a course for the treatment of; 2 weeks can be serve on to chronic bacillary dysentery, within 1 week, to take 2 weeks be again a course for the treatment of in drug withdrawal.Treatment acute bacillary dysentery 50 example, cures 49 examples after a course for the treatment of, progressive 1 example.Average fever time 1.3 days after taking medicine, stomachache, tenesmus extinction time is about 4.8 days, and stool recovered normal time about 4.6 days, and it is normally 5.3 days that stool examination recovers.Treatment chronic bacillary dysentery 4 example, within after drug withdrawal 2 weeks, through sigmoidoscopy, pathological changes all disappears, and coproculture is feminine gender more than 3 times.

Treatment amebic dysentery: 60% Pericarpium Granati decocting liquid often takes 20 milliliters, every day 3 times, taking medicine after meal, and serveing on 6 is a course for the treatment of.A course for the treatment of can be taken again as invalid.Follow up a case by regular visits to half a year after 40 routine patient one courses for the treatment of, all without any symptom, wherein 36 examples continuously excrement examine 3 times and be feminine gender.Period in a medicine is even nauseating, tinnitus, can die away.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.Energy main large migratory arthralgia, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out only.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine is also known as processing Rhizoma Polygonati.The person of being used as medicine is dried for clean Rhizoma Polygonati steams rear section with the adjuvant such as wine and Semen sojae atricolor.Have the merit of meridians of escaping concurrently.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, and slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney.For weakness of the spleen and stomach.Both tonifying spleen-yin, again strengthening the spleen gas, obtain dizzy, soreness of the waist and knees for deficiency of kidney essence, early whitening of beard and hair and quenching one's thirst.Rhizoma Polygonati strengthening bone and muscle, beneficial marrow, bleaches and sends out; The cough expectorant be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

Pericarpium Citri Reticulatae temperature; Pungent, bitter; Return the bitter substance of spleen, lung meridian Pericarpium Citri Reticulatae with limonin and bitter principle for representative " limonoid ", this limonoid taste is gentle, soluble in water, contributes to the digestion of food.When Pericarpium Citri Reticulatae is used for cooking dishes.Its bitterness and other tastes are in harmonious proportion mutually, can form original in style local flavor.Pericarpium Citri Reticulatae contains the compositions such as volatile oil, hesperidin, vitamin B, C, and the volatile oil contained by it has gentle stimulation to gastrointestinal tract, can the secretion of facilitating digestion liquid, gets rid of pneumatosis in intestinal tube, increases appetite.Pericarpium Citri Reticulatae is also conventional Chinese medicine simply, has effect of the spleen invigorating of ventilation, drying dampness to eliminate phlegm, the greasy lasting of solution, stopping nausea and vomiting by lowering the adverse flow of QI.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Rhizoma Atractylodis are pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Rhizoma Atractylodis have drying damp and strengthening spleen, effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia." pearl sac " day: " stomach invigorating can pacify spleen, non-this of all damp-edema can not remove." Compendium of Material Medica says: " control damp-phlegm prolonged fluid-retention ... and spleen wets dirty, turbid drop leukorrhagia, slidingly rush down hemorrhoidal hamorrhage." " Newly Revised Canon of Materia Medica " claim it can " diuresis ".Rhizoma Atractylodis decoct gastric infusion or alcohol preserved material subcutaneous administration, can make normal rabbits blood sugar level raise, but then have hypoglycemic activity to alloxan diabetes rabbit.The Hyperglycemia In Stz-induced Diabetic Rats level that Rhizoma Atractylodis water extract gavage can make chain phleomycin bring out reduces.Have research to think, Rhizoma Atractylodis effective ingredient and adenylic acid play competitive inhibition on same mitochondrion, thus the phosphorylation of T suppression cell internal oxidition, the transfer process of interfering energy.The pharmacological action that effect that Rhizoma Atractylodis are drying damp and strengthening spleen is correlated with is for adjusting gastrointestinal motility function, antiulcer, protecting the liver.Antibacterial etc.The volatile oil that Rhizoma Atractylodis principle active component is is representative with sagittol and hinesol.Rhizoma Atractylodis are on the impact of blood glucose.Anti-hypoxia, CNS inhibition, antitumor, promotion skeleton calcification and on effects such as the impacts of cardiovascular system are then the modern study progress of its pharmacological action.

The Fructus Sophorae has good medical value, and long-term drink can control hemorrhoid by reducing blood pressure and blood fat bowel relieving fire, also has vessel softening, cholesterol reducing, dispelling wind heat, profit large intestine, effect of removing heat from blood relieving constipation.Ambition is unhappy, and conjunctival congestion is shed tears, and dizzy for falling person, normal this tea of drink is quite helpful.Carry according to " herbal classic ", in Fructus Sophorae master five, pathogen heat, only saliva and spittle, mend and hinder absolutely, five hemorrhoid, burn, and married woman's breast abdominal mass, son hides shoot.Supplement to the Herbal carries its parasite killing and removes wind, and improving eyesight is except hot tears, and between brains ambition, hot blast is unhappy, and dizziness due to wind pathogen is for falling, and salivation is as liquor-saturated in mind, ripples as person on ship car." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries its styptic powder cellulitis.Control five hemorrhoid discharging fresh blood stools, red white heat dysentery disease." about can cure mirror " carry its clear away heart-fire, lung, spleen, liver, large intestine fire.Control trusted subordinate's burning pain." book on Chinese herbal medicine asks former " is carried its Fructus Sophorae profit liver and is nourished blood.Control infantile malnutrition, furuncle, dysentery, collapse blood; Nucleon in its angle, supplementing the brain, parasite killing.

Radix Pulsatillae bitter in the mouth, cold in nature; Return stomach, large intestine channel; There is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, effect of removing dampness and killing parasites; Cure mainly pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, the scrofula Radix Pulsatillae is the key medicine controlling amebic dysentery, and alone larger dose is namely effective.Commonly using into square Radix Pulsatillae Decoction, is namely principal agent with this product, coordinates Rhizoma Coptidis, Cortex Phellodendri, Poria form, both can with having controlled amebic dysentery, also can with controlling bacillary dysentery." book on Chinese herbal medicine justice " carries it: Radix Pulsatillae mildly bitter flavor and light, the clear light weight of gas, and " herbal classic " is though the bitter temperature of meaning, so easily mad to cure mainly pyrexial malaria, and Zhong Jing and specially to control diarrhea of heat type with tenesmus, then Bi Feiwen medicine is known.Its main pyretic toxicity dysentery, can let out admittedly though say hardship, and elevate a turnable ladder taste clearing heat in QI system, and make not sag, then tenesmus all removes, really the tangible true essence of this medicine.

Bulbus Allii Macrostemonis is pungent, bitter, temperature.Return lung, stomach, large intestine channel.Regulate the flow of vital energy, the chest stuffiness relieving, activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.Activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery.Supplement to the Herbal carries it: in tune, and main chronic diarrhea is not recovered, normal evil person in large abdomen, but cooks it more.

Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Effect: heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property." Kaibao Bencao ": " clothes not white all the year round.Control carbuncle skin ulcer, kill parasites.Raw juice of smashing takes, and when disliking thing under profit, removes tapeworm." Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.”

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.

Specific embodiment 1:

The summer Depositum urinae preparatum pomegranate go on the market in a large number, removing calyx, by its peeling, cleans and is cut into the slice of 2-4cm, shines to seven, most probably dry, puts aeration-drying place, mothproof.

Again by all the other raw material Herba Portulacaes, the Fructus Sophorae, Rhizoma Polygonati, Bulbus Allii Macrostemonis, Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Rhizoma Atractylodis, Radix Scutellariae extract to concentrate makes granule, powder or unguentum.

The extract of the Pericarpium Granati be mixed with and other raw materials, ultraviolet radiation for sterilizing and disinfecting packs, and directly can take after mixing it with hot water during use.

Specific embodiment 2:

The summer Depositum urinae preparatum pomegranate go on the market in a large number, removing calyx, by its peeling, is cleaned the slice being cut into 2-4cm, shines to seven, most probably does, put aeration-drying place, mothproof, about 5000g.

By surplus stock Herba Portulacae 1500g, Fructus Sophorae 1500g, Rhizoma Polygonati 1500g, Bulbus Allii Macrostemonis 1500g, Poria 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Pericarpium Citri Reticulatae 1500g, Radix Pulsatillae 1500g, Rhizoma Atractylodis 1500g, Radix Scutellariae 1500g clean roguing, dry, be ground into granule, soak 1 hour; Soaked crude drug is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medical material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.Again the Pericarpium Granati prepared is mixed with the granule made, ultraviolet disinfection, pack and get final product.

Specific embodiment 3:

The summer Depositum urinae preparatum pomegranate go on the market in a large number, removing calyx, by its peeling, is cleaned the slice being cut into 2-4cm, shines to seven, most probably does, put aeration-drying place, mothproof, about 3500g.

By surplus stock Herba Portulacae 1100g, Fructus Sophorae 1200g, Rhizoma Polygonati 1100g, Bulbus Allii Macrostemonis 1100g, Poria 1100g, Rhizoma Atractylodis Macrocephalae 1200g, Pericarpium Citri Reticulatae 1200g, Radix Pulsatillae 1100g, Rhizoma Atractylodis 1100g, Radix Scutellariae 1200g, surplus stock component puts into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged; concentrating under reduced pressure relative density is the filtrate of 1.35 (80 DEG C); reclaim ethanol; by gained filtrate adjustment proportion to 1.06; reduce pressure to obtain extractum, then adds Mel and be in harmonious proportion, put into granulator and make 1-2 centimetre of granule; be condensed into pasty state, or convection drying makes powder.The Pericarpium Granati be mixed with, ultraviolet disinfection, packs and get final product.

Specific embodiment 4:

The summer Depositum urinae preparatum pomegranate go on the market in a large number, removing calyx, by its peeling, is cleaned the slice being cut into 2-4cm, shines to seven, most probably does, put aeration-drying place, mothproof, about 4500g.

By surplus stock Herba Portulacae 1300g, Fructus Sophorae 1400g, Rhizoma Polygonati 1400g, Bulbus Allii Macrostemonis 1300g, Poria 1300g, Rhizoma Atractylodis Macrocephalae 1400g, Pericarpium Citri Reticulatae 1400g, Radix Pulsatillae 1300g, Rhizoma Atractylodis 1200g, Radix Scutellariae 1200g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1; Again the medicinal residues that ethanol extraction is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, become component 2, merge component 1 and component 2 paste making agent, the Pericarpium Granati that combination system is got ready, pack.

Pharmacological toxicity is tested

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the health tea that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the health tea decoction agent that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, slow down aging strengthens the drug effects such as metabolism, avirulence.

Pharmacological experiment:

The curative effect of Chinese medicinal healthcare tea of the present invention is proved by pharmacodynamics test below and clinical prerun:

One. the impact of model that Oleum Ricini induced mice is had loose bowels

Get ICR mice 40 (Shandong University's biology laboratory provides), male and female half and half, be divided into model control group at random, rush down and vertical stop group (every sheet is containing sulfamethoxazole 0.4g, trimethoprim 80mg, Semen daturae fluid extract 8mg.Manufacturer: Tianjin Bai Hai Pharmaceutical Co., Ltd production and sales), tea-drinking high dose group of the present invention (all for the present invention raw materials being decocted half an hour, concentrated), low dose group.Give relative medicine 0.2ml/10gB.W. by organizing gavage respectively, model group gives equal-volume normal saline, once a day, and continuous three days.Last administration is after 40 minutes, and every animal gavage gives 0.2ml Oleum Ricini.Then the cell isolation cage of filter paper is placed with immediately below being put into by mice, every lattice one.Observation index: muck counts; Muck counting made by the filter paper spreading 10cm × 10cm area immediately below every cell.React with muck grain number degree of having loose bowels, first 1 ~ 6 hour replacing filter paper per hour once, changes paper once in 7 ~ 24 hours, records the accumulation muck sum of each animal in 24 hours, compares with model control group, with t inspection between SPSS software group.The results are shown in Table one.

The anti-diarrhea effect (X ± SD) of having loose bowels caused by table a pair Oleum Ricini

Note: compare with model control group, * * P < 0.01, * * * P < 0.001

From table one, Chinese medicinal healthcare tea of the present invention can significantly suppress Oleum Ricini induced mice to be had loose bowels.

Two. Small intestine advance activity is tested

Get ICR mice 40, male and female half and half, be divided into Normal group, imodium group (No. H10910085, the accurate word of traditional Chinese medicines ((91) defend No. X-209, the accurate word of medicine), high dose group of the present invention, low dose group at random.Give relative medicine 0.2ml/10gB.W. respectively by organizing gavage respectively, Normal group gives equal-volume normal saline, once a day, and continuous four days.Each group of mice starts fasting 24 hours on the 3rd day upon administration.Test the 4th day, after administration 1 hour, gavage 5% Insta-Char 0.2ml/10gB.W..After 20 minutes, de-cervical vertebra puts to death animal, open abdominal cavity, be separated mesentery, to pylorus on clip, down to the intestinal tube between ileocecus, be placed on flat pallet, gently small intestinal is pulled into straight line, measure Length of intestine as " total small intestinal length ", from pylorus to the distance in prepared Chinese ink forward position as " prepared Chinese ink is at enteral advance distance ".Calculate prepared Chinese ink ink propulsive rate, with t inspection between SPSS software group.The results are shown in Table two.

Table two is on the impact (X ± SD) of Small intestine advance activity

Note: compare with Normal group, * * P < 0.01, * * * P < 0.001.

From table two, the present invention and imodium all have obvious inhibitory action to gastrointestinal propulsive movement.

Three, In vitro Bactericidal Experiments

Double broth dilution method is adopted to measure the minimum inhibitory concentration (MIC) of the present invention to common pathogen.Be inoculated in by tested bacterium in MH broth bouillon, cultivate after 18 hours for 35 DEG C, adjust the turbidity that its turbidity reaches 0.5 Maxwell opacity tube standard, bacterial content is about 108CFU/ml.With physiological saline solution dilution 1: 10 (bacteria containing amount is about 107CFU/m1).Get the medicinal liquid 2ml diluted for series concentration respectively to add and perform in the flat board of labelling, then the MH agar culture medium 18ml being chilled to about 50 DEG C after getting thawing be added to dull and stereotyped in (medicine: agar=1: 9) makes medicine and culture medium fully mix.Medicine ultimate density is respectively 200,100,50 ... 0.78,0.39mg/ml.Be inoculated on pastille flat board by the bacteria suspension inoculating loop prepared, cultivate 18 hours observed results in 35 DEG C, the lowest concentration of drug that colony growth is totally constrained is that this medicine is to the MIC detecting bacterium.Single bacteria growing can be ignored.Drug control and strain growth contrast are established in test simultaneously.The results are shown in Table three.

Table three extracorporeal bacteria inhibitor test result

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/m1)
		Shigella flexneri	4.135
Paratyphoid bacillus A	11.8
		Bacillus paratyphosus B	27
Bacillus pyocyaneus	5.95
		Escherichia coli	51
Colitis bacillus	23
		Staphylococcus aureus	6.18

From table three, the present invention all has certain antibacterial action to shigella flexneri, paratyphoid bacillus A, Bacillus paratyphosus B, escherichia coli, bacillus pyocyaneus, staphylococcus aureus, colitis bacillus.

Specific embodiment:

Money, man, 55 years old.Retire due to illness.Thin and weak, pale complexion is simple and unadorned.Chronic colitis 10 over-carriage is suffered from readme, and every day suffers from diarrhoea 3-4 time, stool malt sugar; Sometimes bleeding after defecation, or hemafecia mixes, color is purple dark, lusterless complexion, spiritlessness and weakness, and dull pain in the epigastrium is indigestion and loss of appetite, loose stool, coldness of the body with chills, tastelessness and thirsty, pale tongue, white and moist fur, thready and weak pulse.JIUYUE in 2012 first visit on the 21st.Repeatedly defecate more than malt sugar band blood June, then send out 2 weeks, be hard and dry, every day one separates, and amount of bleeding is few, mostly is toilet paper band blood, sometimes in bleeding after fatigue, without proctalgia, without Mucous Stool.Once enteroscopy was without exception.Red tongue, yellow and thin fur, thready and rapid pulse.Anus refers to that inspection is without exception, and card belongs to deficiency-weakness of spleen-QI, intestinal flaccidity of muscles and vessels.Take Chinese medicine a lot of year, resisting psychology is produced to Chinese medicine.Control and should support spleen QI invigorating, invigorating the spleen and replenishing QI, loosening bowel to relieve constipation.Prescription: Pericarpium Granati 25g, Herba Portulacae 12g, Fructus Sophorae 13g, Rhizoma Polygonati 11g, Bulbus Allii Macrostemonis 12g, Poria 12g, Rhizoma Atractylodis Macrocephalae 13g, Pericarpium Citri Reticulatae 12g, Radix Pulsatillae 12g, Rhizoma Atractylodis 12g, Radix Scutellariae 12g.Make tea-drinking, every day two wraps, and takes after mixing it with hot water, replaces drinking-water.Further consultation after serveing on 15 days, stool malt sugar improves, have blood in stool without, then take 15 days with former side, chronic dysentery chronic diarrhea is taken good care of better.

Claims

1., for chronic diarrhea chronic dysentery, a Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, it is characterized in that, the parts by weight of the various raw materials of described Tea containing traditional Chinese medicine comprise: Pericarpium Granati 10 ~ 50 parts, Herba Portulacae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Bulbus Allii Macrostemonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, the Radix Pulsatillae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts.

2. a kind of for chronic diarrhea chronic dysentery, the Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described Tea containing traditional Chinese medicine comprise: Pericarpium Granati 10 ~ 30 parts, Herba Portulacae 10 ~ 15 parts, the Fructus Sophorae 10 ~ 15 parts, Rhizoma Polygonati 10 ~ 15 parts, Bulbus Allii Macrostemonis 10 ~ 15 parts, 10 ~ 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, the Radix Pulsatillae 10 ~ 20 parts, Rhizoma Atractylodis 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts.

3. a kind of for chronic diarrhea chronic dysentery, the Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described Tea containing traditional Chinese medicine comprise: Pericarpium Granati 10 ~ 40 parts, Herba Portulacae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Rhizoma Polygonati 10 ~ 20 parts, Bulbus Allii Macrostemonis 10 ~ 20 parts, 10 ~ 20 parts, Poria, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, the Radix Pulsatillae 10 ~ 15 parts, Rhizoma Atractylodis 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts.

4. as described in any one of claims 1 to 3 item for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, it is characterized in that, the preparation process of described Tea containing traditional Chinese medicine comprises following aspect:

A. the preparation of Pericarpium Granati;

5., according to claim 4 for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, it is characterized in that, in described step a, to gather when Punica granatum L. goes on the market Pericarpium Granati, after being cleaned, be cut into the slice of 2-4cm, shine to seven, most probably dry, put aeration-drying place, mothproof.

6., according to claim 4 for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, it is characterized in that, in described step b, by all the other crude drug roguings, dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add the water of other crude drug gross weight 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of other crude drug gross weight 5-7 times amount, decocts 1 ~ 1.5 hour, gets twice decocting liquid mixing, filters; Put into concentrator.

7. according to claim 4 for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, it is characterized in that, in described step c, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, and be concentrated into every 1ml containing 1g crude drug amount, convection drying powdered, adds Mel or dextrin makes granule, powder or unguentum.

8., according to claim 4 for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, it is characterized in that, in described steps d, the powder prepare the Pericarpium Granati prepared and surplus stock or granule mix, and ultraviolet disinfection is packed and be get final product.

9. basis is for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool as described in any one of claims 1 to 3 item, it is characterized in that, when unguentum made by other raw materials of described Tea containing traditional Chinese medicine, step can also be:

C, by 2-in-1 and concentrated to component 1 and component; Lixiviate.

10., according to claim 9 for chronic diarrhea chronic dysentery, the preparation method of Pericarpium Granati Tea containing traditional Chinese medicine of having blood in stool, it is characterized in that: in described step a, get all the other crude drug, steep in the ethanol of other crude drug gross weight 5-10 times amount; Soak 1-2 hour, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; For component 1; In described step b, filtering residue adds water, and boils 45 minutes at every turn, and filter, filtrate is for subsequent use, is component 2; In described step c, the filtrate of extracted twice be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, are condensed into extractum.