CN104435326A - 治疗急性乳腺炎的中药制剂 - Google Patents
治疗急性乳腺炎的中药制剂 Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
治疗急性乳腺炎的中药制剂，选用的原料药材及重量组分分别是：黄柏12份、大黄10份、黄芪15份、柴胡10份、青皮12份、陈皮12份、蒲公英30份、金银花30份、当归15份、玄参24份、王不留行12份、甘草6份、全瓜蒌30份。以上方所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有清热解毒、活血化瘀、消肿止痛的功效，是治疗急性乳腺炎的内服纯中草药组成制剂。
Description
技术领域
本发明属于中药领域，具体涉及一种治疗急性乳腺炎的中药制剂。本发明所述治疗急性乳腺炎的中药制剂，具有清热解毒、活血化瘀、消肿止痛的功效，用于治疗急性乳腺炎疗效确切。
背景技术
急性乳腺炎是乳腺的急性化脓性感染，是乳腺管内和周围结缔组织炎症，多发生于产后哺乳期的妇女，尤其是初产妇更为多见。有文献报道急性乳腺炎初产妇患病占50％，初产妇与经产妇之比为2.4∶1。哺乳期的任何时间均可发生，但以产后3～4周最为常见，故又称产褥期乳腺炎。产褥期乳腺炎是产褥期的常见病，常常继发于乳头皲裂、乳房过度充盈、乳腺管阻塞。产褥期乳腺炎常发生于第一次分娩后，根据病变发展过程分以下两种类型：淤积性乳腺炎和化脓性乳腺炎。产褥期乳腺炎即急性乳腺炎时乳房的化脓性感染，几乎所有病人均为初产妇，发病多在产后3～4周，临床主要表现为乳房的红、肿、热、痛，局部肿块、脓肿形成，体温升高，白细胞计数增高。在脓肿形成前以抗感染促进乳汁排出为主，脓肿形成后以切开引流为主。预后较好。
发明内容
本发明的目的在于提供一种治疗急性乳腺炎的中药制剂。本发明所述治疗急性乳腺炎的中药制剂，具有清热解毒、活血化瘀、消肿止痛的功效，用于治疗急性乳腺炎疗效确切。
本发明采用的技术方案：所述治疗急性乳腺炎的中药制剂，选用的原料药材及重量组分分别是：黄柏12份、大黄10份、黄芪15份、柴胡10份、青皮12份、陈皮12份、蒲公英30份、金银花30份、当归15份、玄参24份、王不留行12份、甘草6份、全瓜蒌30份。
本发明选取的原料中药材中，其功效和药理作用分别是：黄柏：【性味归经】苦，寒。归肾、膀胱、大肠经。【功能与主治】清热燥湿，泻火解毒，除骨蒸清虚热。用于湿热泻痢，黄疸，带下，热淋，脚气，痿辟，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。【化学成分】关黄柏主要含小檗碱约1.6％，尚含掌叶防己碱、黄柏碱、药根碱、黄柏酮、蝙蝠葛任碱、白栝楼碱、木兰碱、柠檬苦素等；根皮分离出小檗碱约9％，尚含药根碱、黄柏碱、白栝楼碱；黄柏小檗碱含量较高达3％。
大黄：性味归经：味苦，性寒。归胃、脾、大肠、肝、心包经。功能主治：具有泻热通便功效，用于胃肠实热积滞、大便秘结、腹部胀满、疼痛拒按，甚至高热不退、神昏谵语，如大承气汤；或脾阳不足之冷积便秘，如温脾汤。解毒消痈功效，用于热毒疮疡、暴赤眼痛、口舌生疮、齿龈肿痛，如大黄牡丹皮汤。行瘀通经功效，用于瘀血阻滞之月经闭止、产后瘀阻、症瘕积聚，及跌打损伤、瘀血肿痛。清热除湿功效，用于湿热壅滞之黄疸、小便不利、大便干结；热淋、石淋如八正散。亦可凉血止血，用于热伤血络之吐血、衄血、便血、崩漏、赤白带下。现代临床可用于治疗流行性脑膜炎、大叶性肺炎、急性胆道感染、急性腮腺炎、急性阑尾炎、急性传染性黄疸型肝炎、急性肠炎、细菌性痢疾、消化道出血、咽喉炎、牙龈脓肿、皮炎、湿疹、淋病、带状疱疹等。
黄芪：具有1、表虚自汗，多用于体虚表弱所致的自汗。2、阴虚盗汗；3、急性肾炎水肿，用于阳气不足所致的虚性水肿；4、慢性肾炎水肿、脾肾虚者；5、阳气虚弱，用于疮疡久不溃破而内陷，有促进溃破及局限作用。6、疮疡久溃不愈，用于疮疡溃破后，久不收口，有生肌收口之作用；7、脾气虚证，虚弱倦怠，泄泻，中气下陷，脏器脱垂，食少纳呆诸症。8、肺气虚证。咳喘日久，气短神疲，痰雍于肺无力咯出。9、多汗而浮肿。10、用于气虚衰弱，倦怠乏力，或中气下陷、脱肛、子宫脱垂。性味：甘，微温。归经：归肺、脾、肝、肾经；有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
柴胡：清虚热中药，用于感冒发热、寒热往来、疟疾、肝郁气滞、胸肋胀痛、脱肛、子宫脱落、月经不调。性味归经：性微寒、味苦、辛、归肝经、肺经、脾经。功能：透表泄热，疏肝解郁，升举阳气。主治：感冒发热、寒热往来、疟疾，肝郁气滞，胸肋胀痛，脱肛，子宫脱落，月经不调。
青皮：主肝郁气滞之胁肋胀痛；乳房胀痛；乳核；乳痈；疝气疼痛；食积气滞之胃脘胀痛；以及气滞血瘀所至的症瘕积聚；久疟癖块。【性味、归经】苦辛、温。入肝、胆、胃经。【功用】疏肝破气、消积化滞。
陈皮：陈皮含橙皮甙约8.4％，川陈皮素(nobiletin)约0。15％.另含辛弗林(对羟福林)0.28％-2。54％。【性味】苦、辛，温。【归经】归肺、脾经。【主治功效】：理气健脾，调中，燥湿，化痰。主治脾胃气滞之脘腹胀满或疼痛、消化不良。湿浊阻中之胸闷腹胀、纳呆便溏。痰湿壅肺之咳嗽气喘。用于胸脘胀满，食少吐泻，咳嗽痰多。
蒲公英：【性味功能】：甘，微苦，寒。清热解毒，消肿散结。【主治】：上呼吸道感染，眼结膜炎，流行性腮腺炎，高血糖，乳痈肿痛，胃炎，痢疾，肝炎，胆襄炎，急性阑尾炎，泌尿系感染，盆腔炎，痈疖疔疮，咽炎，治急性乳腺炎，淋巴腺炎，瘰疠，疔毒疮肿，急性结膜炎，感冒发热，急性扁桃体炎，急性支气管炎、尿路感染。含蒲公英甾醇(Taraxasterol)、胆碱(Choline)、菊糖(Inulin)、果胶(Pectin)；蒲公英醇(Taraxol)、豆甾醇(Stigmasterol)、β-香树脂醇(β-Amyrin)、β-谷甾醇(β-Sitosterol)、蒲公英赛醇(taraxerol)、蒲公英素(Taraxacerin)、蒲公英苦素(Taraxacin)和维生素A、B、C等。
金银花：【性味归经】味甘；寒。归肺；胃经。【功效主治】清热解毒。温病发热；热毒血痢；痈肿疔疮；喉痹及多种感染性疾病。
当归：【化学成分】含基本内酯、正丁烯酰内酯、阿魏酸、烟酸、蔗糖和多种氨基酸，以及倍半萜类化合物等。【性味归经】性温，昧甘、辛。归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。
玄参：【性味归经】：味甘、苦、咸；性微寒。归肺，胃，肾经。【功效】：清热凉血，泻火解毒，滋阴。主治：温热病和营血、身热、烦渴、舌绛、发斑、骨蒸劳嗽、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒。
王不留行：具有活血通经，消肿止痛，催生下乳的功能。主治月经不调，乳汁缺乏，难产，痈肿疔毒等症，是临床常用下乳的重要药。【性味归经】苦，平。归肝，胃经。【功效】活血通经，下乳消痈，利尿通淋。【主治】血瘀经闭，痛经，难产；产后乳汁不下，乳痈肿痛；热淋，血淋，石淋。
甘草：性平，味甘。功能主治：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性，在中医上，甘草补脾益气，止咳润肺，缓急解毒，调和百药。
全瓜蒌：化学成分：含三萜皂甙、有机酸及其盐类、树脂、糖类、精氨酸、赖氨酸、丙氨酸、缬氨酸、异亮氨酸、亮氨酸、甘氨酸及类生物碱物质、色素等；功能主治：清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结。
以上方所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有清热解毒、活血化瘀、消肿止痛的功效，是治疗急性乳腺炎的内服纯中草药组成制剂。临床应用时具有良好的确切效果。
急性乳腺炎的治疗目前探讨不一，近年来我根据数十年的”临床经验，结合独到的用药体会，应用现代药物制备工艺研制出治疗急性乳腺炎的内服纯中药制剂，具有确切疗效。由于其应用效果良好，且不易由现有技术的化合物预见到，西医疗效亦不如中草药疗效，故将有效治愈急性乳腺炎的内服纯中草药组成制剂开发出来，能应用于临床，为更多的患者解除痛苦。
本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。例如可以将这些原料药研成粉末混合均匀散剂冲服；可以将这些原料药一起水煎，然后浓缩煎液服用，或者把浓缩煎液浓缩成膏加工成丸剂服用；为了使该药物的各原料更好地发挥药效，针对某原料药进行特殊提取，如乙醇提取，这些不能用于限制本发明的保护范围。
本发明所述药物具有清热解毒、活血化瘀、消肿止痛的功效，用于治疗急性乳腺炎。本发明人经过反复研究，并通过临床试验的反复验证，终于找到了有更好疗效的内服药物，从而完成了本发明。
临床药效试验材料及典型病例：
1.周XX，女，25岁。初诊日期2013年5月10日。
初产后20余天，左乳头皲裂，乳汁不畅，自觉左乳房胀痛不舒。于5月8日发现左乳房外侧有鸡蛋大小肿块，红、肿、热痛，压痛明显，伴有口渴纳呆，便干溲黄，西医诊断为急性乳腺炎。患者舌质红，苔黄腻，脉弦数。此属乳痈，宜理气活血，清热解毒之法主之。服用本方10剂后，炎症消退，肿块缩小。继续服用本方7剂后，肿块消失，乳汁通畅，诸症消失。
方法和有效量：黄柏12份、大黄10份、黄芪15份、柴胡10份、青皮12份、陈皮12份、蒲公英30份、金银花30份、当归15份、玄参24份、王不留行12份、甘草6份、全瓜蒌30份。取处方规定量中药材饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。
汤剂内服为主，每日早晚2次内服，每次150ml温服。汤剂则作用快而力峻，适应于病情较急重者。如病情较轻或缓者，宜为丸剂内服求其功。
具体实施方式
所述治疗急性乳腺炎的中药制剂，选用的原料药材及重量组分分别是：黄柏12份、大黄10份、黄芪15份、柴胡10份、青皮12份、陈皮12份、蒲公英30份、金银花30份、当归15份、玄参24份、王不留行12份、甘草6份、全瓜蒌30份。
本发明所述治疗急性乳腺炎的中药制剂可以采用中药制剂的常规方法制备成任何常规内服制剂。取处方规定量中药材饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。
Claims (1)
1.一种治疗急性乳腺炎的中药制剂，其特征在于，选用的原料药材及重量组分分别是：黄柏12份、大黄10份、黄芪15份、柴胡10份、青皮12份、陈皮12份、蒲公英30份、金银花30份、当归15份、玄参24份、王不留行12份、甘草6份、全瓜蒌30份；
其制备方法：取处方规定量中药材饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。
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Cited By (4)
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| CN104800420A (zh) * | 2015-04-18 | 2015-07-29 | 臧海阳 | 一种治疗正虚邪恋型急性乳腺炎的中药组合物 |
| CN107693641A (zh) * | 2017-11-01 | 2018-02-16 | 徐瑞彤 | 一种缓解乳腺炎的按摩乳霜 |
| CN108785422A (zh) * | 2017-05-05 | 2018-11-13 | 北京盈科瑞创新医药股份有限公司 | 一种治疗急性乳腺炎的中药组合物及其制备方法 |
| CN114377019A (zh) * | 2022-01-25 | 2022-04-22 | 吉林大学 | β-谷甾醇在缓解奶牛乳腺炎症中的应用 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104800420A (zh) * | 2015-04-18 | 2015-07-29 | 臧海阳 | 一种治疗正虚邪恋型急性乳腺炎的中药组合物 |
| CN108785422A (zh) * | 2017-05-05 | 2018-11-13 | 北京盈科瑞创新医药股份有限公司 | 一种治疗急性乳腺炎的中药组合物及其制备方法 |
| CN108785422B (zh) * | 2017-05-05 | 2021-11-16 | 北京盈科瑞创新药物研究有限公司 | 一种治疗急性乳腺炎的中药组合物及其制备方法 |
| CN107693641A (zh) * | 2017-11-01 | 2018-02-16 | 徐瑞彤 | 一种缓解乳腺炎的按摩乳霜 |
| CN114377019A (zh) * | 2022-01-25 | 2022-04-22 | 吉林大学 | β-谷甾醇在缓解奶牛乳腺炎症中的应用 |
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