CN104435641A - 治疗甲状腺功能亢进症的中药制剂 - Google Patents

治疗甲状腺功能亢进症的中药制剂 Download PDF

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CN104435641A
CN104435641A CN201410636943.3A CN201410636943A CN104435641A CN 104435641 A CN104435641 A CN 104435641A CN 201410636943 A CN201410636943 A CN 201410636943A CN 104435641 A CN104435641 A CN 104435641A
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景东旭
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Abstract

一种治疗甲状腺功能亢进症的中药制剂，其特征在于，选用的原料药材及重量组分分别是：黄药子20份、夏枯草30份、佛手8份、桔梗12份、淡昆布10份、玄参24份、川贝母15份、茯苓15份、当归15份、陈皮12份。本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。例如可以将这些原料药研成粉末混合均匀散剂冲服；可以将这些原料药一起水煎，然后浓缩煎液服用，或者把浓缩煎液浓缩成膏加工成丸剂服用。

Description

治疗甲状腺功能亢进症的中药制剂
技术领域
本发明涉及中药制剂领域，具体涉及一种用于治疗甲状腺功能亢进症的中药制剂。具有滋阴健脾、软坚散结、清肝化痰的功效，治疗甲状腺功能亢进症疗效确切。 
背景技术
甲状腺功能亢进症简称“甲亢”，是由于甲状腺合成释放过多的甲状腺激素，造成机体代谢亢进和交感神经兴奋，引起心悸、出汗、进食和便次增多和体重减少的病症。多数患者还常常同时有突眼、眼睑水肿、视力减退等症状。甲亢病因包括弥漫性毒性甲状腺肿(也称Graves病)，炎性甲亢(亚急性甲状腺炎、无痛性甲状腺炎、产后甲状腺炎和桥本甲亢)、药物致甲亢(左甲状腺素钠和碘致甲亢)、hCG相关性甲亢(妊娠呕吐性暂时性甲亢)、和垂体TSH瘤甲亢。甲状腺激素是促进新陈代谢，促进机体氧化还原反应，代谢亢进需要机体增加进食；胃肠活动增强，出现便次增多；虽然进食增多，但氧化反应增强，机体能量消耗增多，患者表现体重减少；产热增多表现怕热出汗，个别患者出现低热；甲状腺激素增多刺激交感神经兴奋，临床表现心悸、心动过速，失眠，对周围事物敏感，情绪波动，甚至焦虑。甲亢患者长期没有得到合适治疗，会引起消瘦和甲亢性心脏病。患者消瘦常常容易患急性传染病感染致残或死亡。甲亢性心脏病引起心脏扩大，心律失常、心房纤颤和心力衰竭，患者丧失劳动力，其至死亡。 
发明内容
本发明所述治疗甲状腺功能亢进症的中药制剂，具有滋阴健脾、软坚散结、清肝化痰的功效，治疗甲状腺功能亢进症疗效确切。 
选用的原料药材及重量组分分别是：黄药子20份、夏枯草30份、佛手8份、桔梗12份、淡昆布10份、玄参24份、川贝母15份、茯苓15份、当归15份、陈皮12份。 
本发明选取的原料中药材中，其功效和药理作用分别是：黄药子：含有黄独萜酯A(diosbulbine A)、皂甙、鞣质和淀粉。半干燥块茎含蔗糖22.5％、还原糖0.69％、淀粉2.5％、皂甙、鞣质。还含黄独素B，C与薯蓣皂甙元。【性味归经】苦、辛，凉。有小毒。【功能主治】解毒消肿，化痰散结，凉血止血。用于甲状腺肿大，淋巴结结核，咽喉肿痛，吐血，咯血，百日咳，癌肿；外用治疮疖。 
夏枯草：唇形科植物夏枯草Prunella vulgaris L.的干燥果穗。【性味归经】：寒；苦、辛；归肝、胆经。【功能主治】：清火，明目，散结，消肿。用于目赤肿痛，目珠夜痛，头痛眩晕，瘰疬，瘿瘤，肿痛；甲状腺肿大，淋巴结结核，乳腺增生，高血压、高血糖、高血脂和高血粘。 
佛手：性味归经：辛、苦、酸，温。归肝、脾、胃、肺经。功能主治：舒肝理气，和胃止痛，燥湿化痰。用于肝胃气滞，胸胁胀痛，胃脘痞满，食少呕吐，咳嗽痰多。 
桔梗：味苦、辛，性微温。入肺经。能祛痰止咳，并有宣肺、排脓作用。【出处】：《神农本草经》。效】：宣肺、祛痰、利咽、排脓、利五脏、补气血、补五劳、养气。【主治】：咳嗽痰多、咽喉肿痛、肺痈吐脓、胸满胁痛、痢疾腹痛、 口舌生疮、目赤肿痛、小便癃闭。用于咳嗽痰多，胸闷不畅，咽痛，音哑，肺痈吐脓，疮疡脓成不溃。 
淡昆布：[性味、归经]咸寒，入肝、胃、肾经。[功用]消痰软坚，利水消肿。用于瘿瘤瘰疬，水肿等症。 
玄参：【性味归经】：味甘、苦、咸；性微寒。归肺，胃，肾经。【功效】：清热凉血，泻火解毒，滋阴。主治：温热病和营血、身热、烦渴、舌绛、发斑、骨蒸劳嗽、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒。 
川贝母：清热润肺，化痰止咳。用于肺热燥咳，干咳少痰，阴虚劳嗽，咯痰带血。【性味归经】苦、甘，微寒。归肺、心经。【功能主治】清热润肺，化痰止咳。用于肺热燥咳，干咳少痰，阴虚劳嗽，咯痰带血。治虚劳咳嗽、吐痰咯血、心胸郁结、肺痿、肺痈、喉痹、乳痈。 
茯苓：性味甘淡平，入心、肺、脾经。具有渗湿利水，健脾和胃，宁心安神的功效。能增强机体免疫功能，茯苓多糖有明显的抗肿瘤及保肝脏作用。可治小便不利，水肿胀满，痰饮咳逆，呕逆，恶阻，泄泻，遗精，淋浊，惊悸，健忘等症。茯苓之利水，是通过健运脾肺功能而达到的，与其它直接利水的中药不同。 
当归：【化学成分】含基本内酯、正丁烯酰内酯、阿魏酸、烟酸、蔗糖和多种氨基酸，以及倍半萜类化合物等。【性味归经】性温，昧甘、辛。归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。 
陈皮：陈皮含橙皮甙约8.4％，川陈皮素(nobiletin)约0.15％，另含辛 弗林(对羟福林)0.28％-2.54％。【性味】苦、辛，温。【归经】归肺、脾经。【主治功效】：理气健脾，调中，燥湿，化痰。主治脾胃气滞之脘腹胀满或疼痛、消化不良。湿浊阻中之胸闷腹胀、纳呆便溏。痰湿壅肺之咳嗽气喘。用于胸脘胀满，食少吐泻，咳嗽痰多。 
以上方所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有滋阴健脾、软坚散结、清肝化痰的作用，是治疗甲状腺功能亢进症的内服纯中草药组成制剂。 
本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。例如可以将这些原料药研成粉末混合均匀散剂冲服；可以将这些原料药一起水煎，然后浓缩煎液服用，或者把浓缩煎液浓缩成膏加工成丸剂服用；为了使该药物的各原料更好地发挥药效，针对某原料药进行特殊提取，如乙醇提取，这些不能用于限制本发明的保护范围。本发明的活性组分可以加入制备不同剂型时所需的各种常规辅料，如崩解剂、润滑剂、粘合剂等以常规的中药制剂方法制备成任何一种常用口服剂型，如丸剂、散剂、片剂、胶囊剂、口服液等。 
本发明所述药物具有滋阴健脾、软坚散结、清肝化痰的功效，用于治疗甲状腺功能亢进症。本发明人经过反复研究，并通过临床试验的反复验证，终于找到了有更好疗效的内服药物，从而完成了本发明。临床应用是有良好的确切效果： 
临床应用的基本资料及典型病例： 
实施例1.焦XX，男，49岁。2006年7月10日初诊。 
主诉：畏热、多汗、多食，进行性消瘦7个月，心悸5个月。 
现病史：患者于2005年10月，无明显诱因的发现食量增加，大便次数随之增加，量多，便软，成形，无腹痛和脓血便。情绪急躁易怒，身体逐渐消 瘦，体重明显减轻，但饮水量没有增加，小便正常，色黄。前来就诊时，患者脉弦数，舌质红、苔黄腻，此为肝气有余，化火灼津成痰，痰气互结，致成瘿瘤。宜滋阴清肝理气，佐以化痰软坚。服本方15剂后，诸症已消，舌脉正常，病愈。 
方法和有效量：黄药子20份、夏枯草30份、佛手8份、桔梗12份、淡昆布10份、玄参24份、川贝母15份、茯苓15份、当归15份、陈皮12份；取处方规定量中药材饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。 
汤剂内服为主，每日早晚2次内服，每次150ml温服。汤剂则作用快而力峻，适应于病情较急重者。如病情较轻或缓者，宜为丸剂内服求其功。 
具体实施方式
治疗甲状腺功能亢进症的中药制剂，选用的原料药材及重量组分分别是：黄药子20份、夏枯草30份、佛手8份、桔梗12份、淡昆布10份、玄参24份、川贝母15份、茯苓15份、当归15份、陈皮12份。 
本发明药物可以采用中药制剂的常规方法制备成任何常规内服制剂。例如可以将这些原料药研成粉末混合均匀散剂冲服；可以将这些原料药一起水煎，然后浓缩煎液服用，或者把浓缩煎液浓缩成膏加工成丸剂服用。 

Claims (1)

1.一种治疗甲状腺功能亢进症的中药制剂，其特征在于，选用的原料药材及重量组分分别是：黄药子20份、夏枯草30份、佛手8份、桔梗12份、淡昆布10份、玄参24份、川贝母15份、茯苓15份、当归15份、陈皮12份；
制备方法：黄药子20份、夏枯草30份、佛手8份、桔梗12份、淡昆布10份、玄参24份、川贝母15份、茯苓15份、当归15份、陈皮12份；取处方规定量中药材饮片，置适宜煎煮器中，加入清水适量，浸泡适宜时间，加热至沸，保持微沸状态一定时间(约25～30分钟)，分离煎出液，药渣再加水适量煎煮，按规定煎煮2～3次后，合并煎出液，过滤或沉降分离煎出液供使用。
CN201410636943.3A 2014-10-31 2014-10-31 治疗甲状腺功能亢进症的中药制剂 Pending CN104435641A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105521293A (zh) * 2015-12-29 2016-04-27 隋文倩 一种治疗甲亢肌无力的中药口服制剂及其制备方法
CN106138657A (zh) * 2015-04-08 2016-11-23 汤晓芳 一种治疗甲亢的药物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106138657A (zh) * 2015-04-08 2016-11-23 汤晓芳 一种治疗甲亢的药物
CN105521293A (zh) * 2015-12-29 2016-04-27 隋文倩 一种治疗甲亢肌无力的中药口服制剂及其制备方法

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