CN104739979A - 一种内外兼治痤疮的中药 - Google Patents
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Abstract
本发明涉及内外兼治痤疮的药物，尤其是一种以植物中草药为原料制成的内外兼治痤疮的中药。其特征在于：口服汤剂按下述重量为：金银花13-19克，槐花13-19克，桑白皮5-15克，赤芍5-15克，连翘10-20克，当归5-15克，山楂3-9克，丹参13-19克，桃仁3-9克，甘草3-9克；外搽膏剂按下述重量为：细辛2-5克，白芷3-6克，白芍2-5克，海藻3-6克，僵蚕2-5克，赤石脂2-5克。该中药药效协同作用，内外兼用，能够清热解毒，杀菌，消炎，排毒，排脓，有效抑制炎症的发生，还能增加皮肤粘膜的新陈代谢和抑制过敏反应，促进细胞的生长，对治疗痤疮有显著效果。
Description
技术领域
本发明涉及内外兼治痤疮的药物，尤其是一种以植物中草药为原料制成的内外兼治痤疮的中药。
背景技术
痤疮为慢性炎症性毛囊皮脂腺疾病，是皮肤科最常见的疾病之一。痤疮能造成人体皮肤上皮脂腺或毛囊的发炎，局部病变时会产生能挤出白色或乳白色碎米样粉汁的刺状丘疹。中医认为，皮肤是五脏的镜子。痘痘的产生主要与五脏六腑关系密切，中国医学研究表明：痤疮虽生长在皮肤表面，但与脏腑功能失调息息相关。中医认为引起痤疮的原因是：面鼻及胸背部属肺，本病常由肺经风热阻于肌肤所致；或因过食肥甘、油腻、辛辣食物，脾胃蕴热，湿热内生，熏蒸于面而成；或因青春之体，血气方刚，阳热上升，与风寒相搏，郁阻肌肤所致。目前，现代医学主要使用雄激素拮抗剂、抗生素以及维甲酸类药物治疗该病，虽然有一定的疗效，但有明显的副作用，如肝功能受损、骨生成迟缓、内分泌紊乱等。
发明内容
本发明的目的就是针对现有技术治疗痤疮的不足，提供了一种以植物中草药为原料制成的口服汤剂和外搽膏剂所组成的治疗痤疮的中药，通过口服和外搽，起到了根治痤疮的效果，无副作用，无痛苦，不复发。
本发明解决其技术问题所采用的技术方案是：一种治疗痤疮的中药，其特征在于：口服汤剂按下述重量为：金银花13-19克，槐花13-19克，桑白皮5-15克，赤芍5-15克，连翘10-20克，当归5-15克，山楂3-9克，丹参13-19克，桃仁3-9克，甘草3-9克；外搽膏剂按下述重量为：细辛2-5克，白芷3-6克，白芍2-5克，海藻3-6克，僵蚕2-5克，赤石脂2-5克。
用法：口服汤剂一天一剂，水煎服，患者一天可分两次服用。将外搽药制成膏剂，然后用膏剂外搽患处一天两次，一天1次。10天为一个疗程。
本发明的优选技术方案是：：一种治疗痤疮的中药，其特征在于：口服汤剂按下述重量为：金银花16克，槐花16克，桑白皮10克，赤芍10克，连翘15克，当归10克，山楂6克，丹参16克，桃仁6克，甘草6克；外搽膏剂按下述重量为：细辛3克，白芷4克，白芍3克，海藻4克，僵蚕3克，赤石脂3克。
药理作用
金银花：具有清热、解毒、凉血、通经活络之功效。主治风热感冒、咽喉肿痛、肺炎、痢疾、痈肿疙疡、丹毒、蜂窝组织炎等。
槐花：具有凉血止血，清肝泻火的功效；主治肠风便血，痔血，血痢，尿血，血淋，崩漏，吐血，衄血，肝火头痛，目赤肿痛，喉痹，失音，痈疽疮疡。
桑白皮：功效：泻肺平喘，利水消肿。用于肺热咳喘，面目浮肿，小便不利等症。能够抗菌、消炎，具有美容 的作用。
赤芍：清热凉血，散淤止痛，用于温毒发斑，吐血衄血，肝郁胁痛，经闭痛经，症瘕腹痛，跌补损伤，痈肿疮疡。
连翘：清热解毒，散结消肿，主治热病初起，风热感冒，发热，心烦，咽喉肿痛，斑疹，丹毒，瘰疬，痈疮肿毒，急性肾炎，热淋。
当归：补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。
山楂：消食健胃，行气散瘀。用于肉食积滞、胃烷胀满、泻痢腹痛、瘀血经闭、产后瘀阻、心腹刺痛、疝气疼痛、高血脂症。
丹参：活血化瘀，凉血消痈，除烦安神。
桃仁：桃仁性甘平、味苦，入肺、肝、大肠经；活血祛瘀，润肠通便。用于经闭，痛经，癓瘕痞块，跌扑损伤，肠燥便秘。
甘草：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
细辛：解表散寒，祛风止痛，通窍，温肺化饮，解热、利尿、镇痛、镇静药。治头痛，有发汗、祛痰之效。
白芷：祛风除湿；通窃止痛；消肿排脓 ，治头痛，眉棱骨痛，齿痛，鼻渊，寒湿腹痛，肠风痔漏，赤白带下，痈疽疮疡，皮肤燥痒，疥癣。
白芍：具有理血活血化瘀，破血行气，消积止痛，泻胃的功效，用于气滞血瘀，经闭腹痛，症瘕积聚，饮食不节，脾运失常，食积胀痛，脘腹胀满疼痛，治温病发热，热毒血痢，痈疡，肿毒，瘰疬，痔漏等症。
海藻：主要功能是补水美白等
僵蚕：具有祛风定惊，化痰散结的功效，用于惊风抽搐，咽喉肿痛，皮肤瘙痒，颌下淋巴结炎，面神经麻痹等症。
赤石脂：涩肠，止血，收湿，生肌。治久泻，久痢，便血，脱肛，遗精，崩漏，带下，溃疡不敛。
本发明的有益效果是，本发明中药的各组分均采用天然的中药原料，其配置简单，药源广、成本低。该中药药效协同作用，内外兼用，能够清热解毒，杀菌，消炎，排毒，排脓，有效抑制炎症的发生，还能增加皮肤粘膜的新陈代谢和抑制过敏反应，促进细胞的生长，对治疗痤疮有显著效果。
下面结合临床实验数据说明本发明的有益效果
1 临床资料
研究对象
发明人2010年6月到2011年9月间共收集痤疮的门诊108例，男62例，女46例，年龄13-35岁。随机分成两组，其中治疗组54例，男30例，女24例；年龄5-42岁，病程半个月到5年，对照组54例，男32例，女22例，年龄13-36岁之间；病程半个月到6年，两组患者的性别、年龄、病程比较差异无统计学意义（P>0.05），具有可比性。
排除标准
排除标准：妊娠或哺乳期妇女；
其他类型的痤疮；
对药物成分过敏者；
不能遵守医嘱者。
诊断标准
参照《中药新药临床研究指导原则》。症状程度分级参照PiU Sburv及国际改良痤疮分级法：I级：主要皮损为黑头粉刺，散发至多发，炎性丘疹散发，总病灶数10～30个；Ⅱ级：主要皮损为粉刺，并有中等数量的丘疹和潜在性脓疱，总病灶数31—50个；Ⅲ级：主要皮损为深在炎症性丘疹和脓疱，总病灶数51—100个，结节<3个，发生于颜面、颈部、胸背部；Ⅳ级：皮损为深在炎症性丘疹和脓疱，总病灶数>100个，结节、囊肿>3个，容易形成瘢痕，发生于上半身。I、Ⅱ级为轻度，Ⅲ级为中度，Ⅳ级为重度。
2 试验方法
治疗方法
对照组 口服甲硝唑VB6片，2片/次，3次/，外用0.025%维A酸乳膏，1次/晚。
治疗组 采用本发明治疗痤疮的中药，内服口服汤剂，一天一剂，分两次服用，外敷外搽膏剂，一天两次，一天1次。
对照组与治疗组均是10天为一个疗程，最少治疗6个疗程。
观察指标
安全性观测：三大常规、肝肾功能分别于治疗前、后各检查1次。服药期间如实记录所出现的不良反应。
疗效观察：观察皮损的形态、性质、颜色、面积、疼痛程度观察有无面红、便秘或便溏、尿黄、腹胀、鼻息气热、口臭、月经不调等。
3疗效标准
参照《中药新药临床研究指导原则》。治愈：丘疹、脓疮或囊性结节全部消失，自觉症状消失；好转：丘疹脓疮或囊性结节大部分消失，自觉症状明显减轻，皮损消退30％以上；无效：病情反复发作，皮损及症状无变化或消退不足30％。
治疗效果
治疗统计结果见表1
表1
临床观察表明，本发明对治疗痤疮具有很好的疗效，优势明显，且本发明中药价格低廉，。
典型病例
秦某某，女，27岁患者，患者面部座疮已有4年多，米粒大小痤疮遍布面颊及前额部，面颊部痤疮融合成片，色红，尖部有脓胞。整个面部出油较多，吃油腻、辛辣食物及月经前症状加重，并伴有痛经，大便不调，一或二日一行。曾用过多种方法包括口服及外涂激素类药物、中药及美容院的专门治疗，但效果均不显著。2010年10月开始内服外搽治疗痤疮的中药，2个疗程后，面部痤疮减少，出油也减少，继续坚持4个疗程，痊愈，痤疮基本完全消失，至今无复发。
徐某某，女，23岁，满脸痤疮5余年，患者,5余年前开始出现满脸痤疮，曾服清热解毒中药和西药、药膏内服、外用半年，略能控制，停药后痤疮随即复发，患者症状面色黄暗红，面颊、额头、下巴部位大量粉刺、丘疹、脓疱、结节，色暗红，高出皮肤，触之压痛，凹洞疤痕明显，确诊为疮，2011年3月开始内服外搽治疗痤疮的中药，2个疗程后，面部痤疮减少，出油也减少，继续坚持4个疗程，痊愈，痤疮基本完全消失，至今无复发。
具体实施方式
取金银花16克，槐花16克，桑白皮10克，赤芍10克，连翘15克，当归10克，山楂6克，丹参16克，桃仁6克，甘草6克；先将药物用水洗净后，用冷水浸泡15-20分钟，然后将药物放在砂锅、陶瓷或者瓦罐之类的器皿里（不可以用铁锅和铝锅），加水至没过药面5厘米左右，进行第一次煎煮，用大火煮沸后，改用小火煎煮20-30分钟就好，将药汤倒在器皿里，再煎第二遍，煎煮第二遍的方法同第一遍一样，只是煮沸后用小火煎煮15-20分钟即可。煎完以后，两次煎煮去渣取汁，合并后服用。
取细辛3克，白芷4克，白芍3克，海藻4克，僵蚕3克，赤石脂3克，将其混合后呈细粉，过100目筛，装瓶备用。外用时，取药粉适量，以凉开水或绿茶水调成糊状，均匀敷于炎性丘疹、脓疱、结节、囊肿上，以覆盖皮损为度，待其自然干燥后清洁去除，每日1次。
Claims (2)
1. 一种治疗痤疮的中药，其特征在于：口服汤剂按下述重量为：金银花13-19克，槐花13-19克，桑白皮5-15克，赤芍5-15克，连翘10-20克，当归5-15克，山楂3-9克，丹参13-19克，桃仁3-9克，甘草3-9克；外搽膏剂按下述重量为：细辛2-5克，白芷3-6克，白芍2-5克，海藻3-6克，僵蚕2-5克，赤石脂2-5克。
2.根据权利要求1所述治疗痤疮的中药，其特征在于：口服汤剂按下述重量为：金银花16克，槐花16克，桑白皮10克，赤芍10克，连翘15克，当归10克，山楂6克，丹参16克，桃仁6克，甘草6克；外搽膏剂按下述重量为：细辛3克，白芷4克，白芍3克，海藻4克，僵蚕3克，赤石脂3克。
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| CN108543044A (zh) * | 2018-05-28 | 2018-09-18 | 四川省中医药科学院中医研究所 | 一种治疗痤疮的联合用药物及其用途 |
| CN113116982A (zh) * | 2021-05-26 | 2021-07-16 | 星米(海南经济特区)生物科技有限公司 | 一种祛痘中药配方及制作工艺 |
| CN118831115A (zh) * | 2024-07-25 | 2024-10-25 | 中国人民解放军总医院第五医学中心 | 用于治疗和/或预防脓毒症的中药组合物、药物制剂及用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108543044A (zh) * | 2018-05-28 | 2018-09-18 | 四川省中医药科学院中医研究所 | 一种治疗痤疮的联合用药物及其用途 |
| CN108543044B (zh) * | 2018-05-28 | 2021-05-07 | 四川省中医药科学院中医研究所 | 一种治疗痤疮的联合用药物及其用途 |
| CN113116982A (zh) * | 2021-05-26 | 2021-07-16 | 星米(海南经济特区)生物科技有限公司 | 一种祛痘中药配方及制作工艺 |
| CN118831115A (zh) * | 2024-07-25 | 2024-10-25 | 中国人民解放军总医院第五医学中心 | 用于治疗和/或预防脓毒症的中药组合物、药物制剂及用途 |
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