CN104435136A - Pharmaceutical composition for accelerating fracture healing and preparation method thereof - Google Patents
Pharmaceutical composition for accelerating fracture healing and preparation method thereof Download PDFInfo
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- CN104435136A CN104435136A CN201410797657.5A CN201410797657A CN104435136A CN 104435136 A CN104435136 A CN 104435136A CN 201410797657 A CN201410797657 A CN 201410797657A CN 104435136 A CN104435136 A CN 104435136A
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- rhizoma
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- ointment
- fracture
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 206010017076 Fracture Diseases 0.000 title abstract description 45
- 208000010392 Bone Fractures Diseases 0.000 title abstract description 44
- 230000035876 healing Effects 0.000 title abstract description 10
- 241000218176 Corydalis Species 0.000 claims abstract description 31
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 29
- 239000000341 volatile oil Substances 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 239000002674 ointment Substances 0.000 claims description 39
- 241001489978 Eupolyphaga Species 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 238000000605 extraction Methods 0.000 claims description 25
- 241000756943 Codonopsis Species 0.000 claims description 21
- 239000009636 Huang Qi Substances 0.000 claims description 21
- 238000005325 percolation Methods 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 16
- 239000002775 capsule Substances 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 238000007598 dipping method Methods 0.000 claims description 7
- 230000011218 segmentation Effects 0.000 claims description 7
- 238000001256 steam distillation Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 17
- 230000001737 promoting effect Effects 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 13
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- 210000004369 blood Anatomy 0.000 abstract description 9
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- 230000008736 traumatic injury Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 3
- 241000112528 Ligusticum striatum Species 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 241000007126 Codonopsis pilosula Species 0.000 abstract 1
- 244000190529 Cynoglossum amabile Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 206010049514 Traumatic fracture Diseases 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 230000008961 swelling Effects 0.000 description 6
- 239000002671 adjuvant Substances 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 230000006837 decompression Effects 0.000 description 5
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- 206010020649 Hyperkeratosis Diseases 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 206010059240 Lymphostasis Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002565 Open Fractures Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to the field of fracture medicines and particularly relates to a pharmaceutical composition for accelerating fracture healing and a preparation method thereof. The pharmaceutical composition is mainly prepared from the following raw materials in parts by weight: 120-180 parts of teasel roots, 200-250 parts of rhizoma drynariae, 100-150 parts of Chinese forgetmenot roots, 100-150 parts of codonopsis pilosula, 110-150 parts of astragalus membranaceus, 120-180 parts of ligusticum wallichii, 150-200 parts of corydalis tubers, 110-140 parts of ground beetles and 5-10 parts of borneol. By treating the raw materials in different modes, the active ingredients of the raw materials obtained are relatively high. In addition, volatile oil of ligusticum wallichii is separately extracted, so that the active ingredients of the finally prepared medicine are good in synergetic enhancement effect. When applied to treatment of traumatic injuries and fractures and the like, the prepared pharmaceutical composition has very good effects of promoting blood circulation to remove blood stasis, setting fractures, reuniting tendons, accelerating fracture healing and the like.
Description
Technical field
The present invention relates to fracture drug world, in particular to a kind of pharmaceutical composition promoting union of fracture and preparation method thereof.
Background technology
Integrity or the seriality of bone are destroyed, and namely claim fracture.Clinically to the description of fracture, often name according to the feature of the region of anatomy of the reason of wound, wound, fracture line, skin or mucosal breaks, such as lower end of radius stretches type open fracture.Generally need joint, Plastering, Boards wall to make to be joined together by self-sow between bone after fracture.Fracture is associated with surrounding soft tissue's swelling more, and can affect venous return, cause disorder of limb ' s activity and pain, if processed not in time, then cause and organize rehabilitation duration to extend, growth of spur is slow.
After fracture, patient there will be pain in various degree and soft tissue swelling, and add the misery of patient, swelling turn increases the obstacle of local blood circulation, and the local meridian qi and blood stasis of blood is stagnant obstructed, and bone is become homeless foster, directly affects the speed degree of union of fracture.Modern medicine thinks that swelling Producing reason mainly: traumatic inflammation reacts, and hemorrhage owing to organizing after damage, body fluid oozes out, and simultaneously due to pain, reflexive causes muscle spasm, pump event resolves, causes vein and lymphatic vessel to be retarded by silt, backflow obstacle; Long-term limbs are fixed, and muscle does not move generation amyotrophy, and muscle elastic force reduces, and loses muscle systolic and diastolic function, cause vein and lymphatic vessel backflow slowly or be retarded by silt.Due to long-term intravenous, lymphostasis, its tube wall is expanded, and permeability increases, and causes edema between tissue, not only can affect the backflow of muscle arteries and veins, and can affect tremulous pulse blood supply, make limb rehabilitating can not get enough nutrition and blood supply.In addition, swollen tissue often makes extenal fixation (clamping plate or Gypsum Fibrosum) be not suitable for and must change or adjust clamping plate elasticity, otherwise by the therapeutic outcome of impact fracture, and affect functional exercise and the recovery of suffering limb, delay the healing of fracture, therefore detumescence is very important early.In addition, after detumescence, Promotive union is also particularly important.
Doctor trained in Western medicine, in treatment fracture swelling and Promotive union, mainly adopts the mode of analgesic antiphlogistic, DeGrain, and has side effect.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition promoting union of fracture, the pharmaceutical composition of described promotion union of fracture is applied in the treatment such as traumatic injury, fracture, has the effects such as extraordinary blood circulation promoting and blood stasis dispelling, reunion of bone, promotion union of fracture.
The second object of the present invention is the preparation method of the pharmaceutical composition providing a kind of described promotion union of fracture, and the effective ingredient content that the method is extracted is high, effective.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of pharmaceutical composition promoting union of fracture, make primarily of following raw material, by weight, Radix Dipsaci 120-180 part, Rhizoma Drynariae 200-250 part, Rhizoma seu Herba Elatostematis stewardii 100-150 part, Radix Codonopsis 100-150 part, Radix Astragali 110-150 part, Rhizoma Chuanxiong 120-180 part, Rhizoma Corydalis 150-200 part, Eupolyphaga Seu Steleophaga 110-140 part, Borneolum Syntheticum 5-10 part.
The pharmaceutical composition of promotion union of fracture provided by the invention, make primarily of Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, the Radix Astragali, Rhizoma Chuanxiong, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Borneolum Syntheticum, the active component of each raw material cooperatively interacts, the pharmaceutical composition of obtained promotion union of fracture is applied in the treatment such as traumatic injury, fracture, has the effects such as extraordinary blood circulation promoting and blood stasis dispelling, reunion of bone, promotion union of fracture.
In order to increase the mutual chemiluminescence between each raw material active component further, preferably, by weight, Radix Dipsaci 140-160 part, Rhizoma Drynariae 210-230 part, Rhizoma seu Herba Elatostematis stewardii 110-130 part, Radix Codonopsis 120-135 part, Radix Astragali 130-140 part, Rhizoma Chuanxiong 140-160 part, Rhizoma Corydalis 170-190 part, Eupolyphaga Seu Steleophaga 120-130 part, Borneolum Syntheticum 7-9 part.
More preferably, by weight, Radix Dipsaci 150 parts, Rhizoma Drynariae 220 parts, Rhizoma seu Herba Elatostematis stewardii 120 parts, Radix Codonopsis 125 parts, the Radix Astragali 135 parts, Rhizoma Chuanxiong 150 parts, Rhizoma Corydalis 180 parts, Eupolyphaga Seu Steleophaga 125 parts, Borneolum Syntheticum 8 parts.
Present invention also offers the preparation method of the pharmaceutical composition of described promotion union of fracture, comprise the following steps:
(1) Eupolyphaga Seu Steleophaga and Borneolum Syntheticum are ground into segmentation respectively, for subsequent use;
(2) Rhizoma Chuanxiong volatile oil is extracted, for subsequent use;
(3) Rhizoma Corydalis is ground into coarse powder, extracts, obtain extracting solution, described extracting solution is concentrated into ointment, obtain the first ointment;
(4) get the medicinal residues after Rhizoma Chuanxiong, Rhizoma Corydalis extraction, decoct with water with Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, the Radix Astragali, obtain decocting liquid, described decocting liquid is concentrated into ointment, obtain the second ointment;
(5) merge described first ointment and the second ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing obtains mixture, to obtain final product.
The preparation method of the pharmaceutical composition of promotion union of fracture provided by the invention, different processing modes is adopted to each raw material, the active component of each material composition obtained is higher, in addition, the volatile oil of independent extraction Rhizoma Chuanxiong, to make in final obtained medicine between each active component better chemiluminescence, there is the effects such as extraordinary blood circulation promoting and blood stasis dispelling, reunion of bone, promotion union of fracture.
Wherein, coarse powder refers to that particle diameter is between 15-25 order.
In order to better retain the effective active composition in Rhizoma Chuanxiong, preferably, in step (2), adopt extraction by steam distillation Rhizoma Chuanxiong volatile oil, extraction time is 3-5h.
Preferably, in step (3), described extraction adopts percolation;
Described percolation is with 70%-80% ethanol as solvent, after dipping 45-50h, with the speed percolation of 1 ~ 3ml per minute, collects percolate, is described extracting solution.
With 70%-80% ethanol as solvent, Rhizoma Corydalis is flooded, its effective active composition can better be extracted.The weight ratio of solvent and Rhizoma Corydalis is 3 ~ 5:1, better to extract its effective active composition, and saves the number of times extracted.
Preferably, in step (3), the relative density of described first ointment under the condition of 60 DEG C is 1.20 ~ 1.30.Be concentrated into the ointment of this concentration, be both easy to preserve, be easy to again follow-up processing.
In order to be extracted more fully by the effective active composition in Rhizoma Chuanxiong medicinal residues, Rhizoma Corydalis medicinal residues, Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, the Radix Astragali, preferably, in step (4), the number of times of described decoction is 2-3 time.The time decocted is 3 hours first times, second time 2 hours, 1 hour third time, merges decoction liquor, filters and obtain decocting liquid.
Further, in step (4), the relative density of described second ointment under the condition of 60 DEG C is 1.20 ~ 1.30.Be concentrated into the ointment of this concentration, be both easy to preserve, be easy to again follow-up processing.
Further, in step (5), described mixture makes any one in granule, capsule, tablet, pill.Namely merge two kinds of ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing, then add appropriate amount of auxiliary materials, make the clinical applicable dosage forms such as granule, capsule, tablet, pill, so that patient takes.
Compared with prior art, beneficial effect of the present invention is:
(1) the present invention is specific selects Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, the Radix Astragali, Rhizoma Chuanxiong, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga, Borneolum Syntheticum to be raw material, the active component of each raw material cooperatively interacts, the pharmaceutical composition of obtained promotion union of fracture is applied in the treatment such as traumatic injury, fracture, has the effects such as extraordinary blood circulation promoting and blood stasis dispelling, reunion of bone, promotion union of fracture;
(2) the present invention is by limiting the proportioning between each raw material, better to strengthen the chemiluminescence of each material composition;
(3) present invention also offers the preparation method of the pharmaceutical composition promoting union of fracture, different processing modes is adopted to each raw material, the active component of each material composition obtained is higher, in addition, the volatile oil of independent extraction Rhizoma Chuanxiong, in final obtained medicine, chemiluminescence between each active component, has the effects such as extraordinary blood circulation promoting and blood stasis dispelling, reunion of bone, promotion union of fracture.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercially available acquisition.
Embodiment 1
Get following raw material, by weight, Radix Dipsaci 120 parts, Rhizoma Drynariae 200 parts, Rhizoma seu Herba Elatostematis stewardii 100 parts, Radix Codonopsis 100 parts, the Radix Astragali 110 parts, Rhizoma Chuanxiong 120 parts, Rhizoma Corydalis 150 parts, Eupolyphaga Seu Steleophaga 110 parts, Borneolum Syntheticum 5 parts;
Be prepared in the following ways:
(1) Eupolyphaga Seu Steleophaga and Borneolum Syntheticum are ground into segmentation respectively, for subsequent use;
(2) adopt extraction by steam distillation Rhizoma Chuanxiong volatile oil, extraction time is 3h, the aqueous solution container collection after distillation, for subsequent use;
(3) Rhizoma Corydalis is ground into coarse powder, extract according to the percolation under (Chinese Pharmacopoeia annex 10) fluid extract and extractum item, with 70% ethanol as solvent, after dipping 45h, with the speed percolation of 1ml per minute, collect percolate, decompression recycling ethanol is also concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(4) medicinal residues after Rhizoma Chuanxiong, Rhizoma Corydalis extraction are got, three times are decocted with water with Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, Radix Astragali Chinese medicine of the five flavours material, 3 hours first times, second time 2 hours, 1 hour third time, collecting decoction, filter, filtrate is concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(5) merge the first ointment and the second ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing, adds adjuvant, makes capsule.
Embodiment 2
Get following raw material, by weight, Radix Dipsaci 140 parts, Rhizoma Drynariae 210 parts, Rhizoma seu Herba Elatostematis stewardii 130 parts, Radix Codonopsis 135 parts, the Radix Astragali 130 parts, Rhizoma Chuanxiong 140 parts, Rhizoma Corydalis 190 parts, Eupolyphaga Seu Steleophaga 120 parts, Borneolum Syntheticum 7 parts;
Be prepared in the following ways:
(1) Eupolyphaga Seu Steleophaga and Borneolum Syntheticum are ground into segmentation respectively, for subsequent use;
(2) adopt extraction by steam distillation Rhizoma Chuanxiong volatile oil, extraction time is 4h, the aqueous solution container collection after distillation, for subsequent use;
(3) Rhizoma Corydalis is ground into coarse powder, extract according to the percolation under (Chinese Pharmacopoeia annex 10) fluid extract and extractum item, with 75% ethanol as solvent, after dipping 48h, with the speed percolation of 2ml per minute, collect percolate, decompression recycling ethanol is also concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(4) medicinal residues after Rhizoma Chuanxiong, Rhizoma Corydalis extraction are got, three times are decocted with water with Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, Radix Astragali Chinese medicine of the five flavours material, 3 hours first times, second time 2 hours, 1 hour third time, collecting decoction, filter, filtrate is concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(5) merge the first ointment and the second ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing, adds adjuvant, makes capsule.
Embodiment 3
Get following raw material, by weight, Radix Dipsaci 160 parts, Rhizoma Drynariae 230 parts, Rhizoma seu Herba Elatostematis stewardii 110 parts, Radix Codonopsis 120 parts, the Radix Astragali 140 parts, Rhizoma Chuanxiong 160 parts, Rhizoma Corydalis 170 parts, Eupolyphaga Seu Steleophaga 130 parts, Borneolum Syntheticum 9 parts;
Be prepared in the following ways:
(1) Eupolyphaga Seu Steleophaga and Borneolum Syntheticum are ground into segmentation respectively, for subsequent use;
(2) adopt extraction by steam distillation Rhizoma Chuanxiong volatile oil, extraction time is 5h, the aqueous solution container collection after distillation, for subsequent use;
(3) Rhizoma Corydalis is ground into coarse powder, extract according to the percolation under (Chinese Pharmacopoeia annex 10) fluid extract and extractum item, with 80% ethanol as solvent, after dipping 45h, with the speed percolation of 3ml per minute, collect percolate, decompression recycling ethanol is also concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(4) medicinal residues after Rhizoma Chuanxiong, Rhizoma Corydalis extraction are got, three times are decocted with water with Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, Radix Astragali Chinese medicine of the five flavours material, 3 hours first times, second time 2 hours, 1 hour third time, collecting decoction, filter, filtrate is concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(5) merge the first ointment and the second ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing, adds adjuvant, makes capsule.
Embodiment 4
Get following raw material, by weight, Radix Dipsaci 150 parts, Rhizoma Drynariae 220 parts, Rhizoma seu Herba Elatostematis stewardii 120 parts, Radix Codonopsis 125 parts, the Radix Astragali 135 parts, Rhizoma Chuanxiong 150 parts, Rhizoma Corydalis 180 parts, Eupolyphaga Seu Steleophaga 125 parts, Borneolum Syntheticum 8 parts;
Be prepared in the following ways:
(1) Eupolyphaga Seu Steleophaga and Borneolum Syntheticum are ground into segmentation respectively, for subsequent use;
(2) adopt extraction by steam distillation Rhizoma Chuanxiong volatile oil, extraction time is 4h, the aqueous solution container collection after distillation, for subsequent use;
(3) Rhizoma Corydalis is ground into coarse powder, extract according to the percolation under (Chinese Pharmacopoeia annex 10) fluid extract and extractum item, with 75% ethanol as solvent, after dipping 50h, with the speed percolation of 2ml per minute, collect percolate, decompression recycling ethanol is also concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(4) medicinal residues after Rhizoma Chuanxiong, Rhizoma Corydalis extraction are got, secondary is decocted with water with Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, Radix Astragali Chinese medicine of the five flavours material, 3 hours first times, second time 2 hours, collecting decoction, filter, filtrate is concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(5) merge the first ointment and the second ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing, adds adjuvant, makes capsule.
Embodiment 5
Get following raw material, by weight, Radix Dipsaci 180 parts, Rhizoma Drynariae 250 parts, Rhizoma seu Herba Elatostematis stewardii 150 parts, Radix Codonopsis 150 parts, the Radix Astragali 150 parts, Rhizoma Chuanxiong 180 parts, Rhizoma Corydalis 200 parts, Eupolyphaga Seu Steleophaga 140 parts, Borneolum Syntheticum 10 parts;
Be prepared in the following ways:
(1) Eupolyphaga Seu Steleophaga and Borneolum Syntheticum are ground into segmentation respectively, for subsequent use;
(2) adopt extraction by steam distillation Rhizoma Chuanxiong volatile oil, extraction time is 5h, the aqueous solution container collection after distillation, for subsequent use;
(3) Rhizoma Corydalis is ground into coarse powder, extract according to the percolation under (Chinese Pharmacopoeia annex 10) fluid extract and extractum item, with 80% ethanol as solvent, after dipping 50h, with the speed percolation of 1ml per minute, collect percolate, decompression recycling ethanol is also concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(4) medicinal residues after Rhizoma Chuanxiong, Rhizoma Corydalis extraction are got, three times are decocted with water with Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, Radix Astragali Chinese medicine of the five flavours material, 3 hours first times, second time 2 hours, 1 hour third time, collecting decoction, filter, filtrate is concentrated into the ointment that relative density is 1.20 ~ 1.30 (60 DEG C);
(5) merge the first ointment and the second ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing, adds adjuvant, makes capsule.
Experimental example
Part in embodiment 1-5 is pressed g and is calculated, and makes capsule 1000, every dress 0.45g.Capsule prepared by the medicine adopting embodiment of the present invention 1-5 to obtain carries out the treatment clinical observation promoting union of fracture, often group is 40 people, be divided into 6 groups, the capsule that group 1-5 correspondence uses embodiment 1-5 to prepare, the Shiweihuoxue piUls treatment that group 6 uses Chongqing Hil'an Pharmaceutical Co., Ltd to produce is observed in contrast.Wherein, the mean age is 35 years old, the course of disease 4 ~ 6 weeks.
Diagnostic criteria is with reference to union of fracture clinical criteria in " new Chinese medicine guideline of clinical investigations ".Capsule prepared by embodiment 1-5 takes 3 times on 1st, each 3; Matched group: give Shiweihuoxue piUls (Chongqing Hil'an Pharmaceutical Co., Ltd produces, lot number: 20110301, the accurate word Z20027409 of traditional Chinese medicines), the heavy 1g of every ten balls, takes 2 times on 1st, each 3 ~ 6g.Administration time is not all 4 ~ 8 weeks according to fracture site, and period in a medicine is stopped using other similar drugs.
Criterion of therapeutical effect:
Clinical healing: x-ray takes the photograph sheet display fracture site obviously callus formation continuously, still visible fracture line, broken ends of fractured bone activity without exception;
Effective: within 12 weeks, not reach complete clinical healing person after fracture, but have callus formation sign;
Invalid: the person that do not reach clinical healing in 32 weeks after fracture.
Statistical method: application SPSS11.0 statistical package carries out statistical analysis, and the comparison of enumeration data rate adopts X
2inspection.
The result obtained is as shown in table 1.
Table 1 union of fracture clinical efficacy
| Group | Clinical healing | Effectively | Invalid | Effective percentage |
| Group 1 | 28 | 7 | 5 | 87.5％ |
| Group 2 | 29 | 7 | 4 | 90％ |
| Group 3 | 30 | 7 | 3 | 92.5％ |
| Group 4 | 28 | 8 | 4 | 90％ |
| Group 5 | 29 | 7 | 4 | 90％ |
| Group 6 | 20 | 11 | 9 | 77.5％ |
Above result shows, treatment group clinical healing rate is apparently higher than matched group clinical healing rate (P < 0.05), and the total effective rate for the treatment of group is better than matched group.Period in a medicine, the speed of detumescence, is obviously better than matched group, and pain alleviates, without any side effects.
In addition, the pharmaceutical composition of promotion union of fracture provided by the invention has also been prepared into pill, tablet, is applied to traumatic injury patient, and having well subsides a swelling relieves the pain, the effect of blood circulation promoting and blood stasis dispelling, general use can recover normal for 3-5 days, action effect highly significant.
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.
Claims (10)
1. one kind promotes the pharmaceutical composition of union of fracture, it is characterized in that, make primarily of following raw material, by weight, Radix Dipsaci 120-180 part, Rhizoma Drynariae 200-250 part, Rhizoma seu Herba Elatostematis stewardii 100-150 part, Radix Codonopsis 100-150 part, Radix Astragali 110-150 part, Rhizoma Chuanxiong 120-180 part, Rhizoma Corydalis 150-200 part, Eupolyphaga Seu Steleophaga 110-140 part, Borneolum Syntheticum 5-10 part.
2. the pharmaceutical composition of promotion union of fracture according to claim 1, it is characterized in that, by weight, Radix Dipsaci 140-160 part, Rhizoma Drynariae 210-230 part, Rhizoma seu Herba Elatostematis stewardii 110-130 part, Radix Codonopsis 120-135 part, Radix Astragali 130-140 part, Rhizoma Chuanxiong 140-160 part, Rhizoma Corydalis 170-190 part, Eupolyphaga Seu Steleophaga 120-130 part, Borneolum Syntheticum 7-9 part.
3. the pharmaceutical composition of promotion union of fracture according to claim 1, it is characterized in that, by weight, Radix Dipsaci 150 parts, Rhizoma Drynariae 220 parts, Rhizoma seu Herba Elatostematis stewardii 120 parts, Radix Codonopsis 125 parts, the Radix Astragali 135 parts, Rhizoma Chuanxiong 150 parts, Rhizoma Corydalis 180 parts, Eupolyphaga Seu Steleophaga 125 parts, Borneolum Syntheticum 8 parts.
4. the preparation method of the pharmaceutical composition of the promotion union of fracture described in any one of claim 1-3, is characterized in that, comprise the following steps:
(1) Eupolyphaga Seu Steleophaga and Borneolum Syntheticum are ground into segmentation respectively, for subsequent use;
(2) Rhizoma Chuanxiong volatile oil is extracted, for subsequent use;
(3) Rhizoma Corydalis is ground into coarse powder, extracts, obtain extracting solution, described extracting solution is concentrated into ointment, obtain the first ointment;
(4) get the medicinal residues after Rhizoma Chuanxiong, Rhizoma Corydalis extraction, decoct with water with Radix Dipsaci, Rhizoma Drynariae, Rhizoma seu Herba Elatostematis stewardii, Radix Codonopsis, the Radix Astragali, obtain decocting liquid, described decocting liquid is concentrated into ointment, obtain the second ointment;
(5) merge described first ointment and the second ointment, add Eupolyphaga Seu Steleophaga, Borneolum Syntheticum fine powder and Rhizoma Chuanxiong volatile oil, mixing obtains mixture, to obtain final product.
5. the preparation method of the pharmaceutical composition of promotion union of fracture according to claim 4, is characterized in that, in step (2), adopt extraction by steam distillation Rhizoma Chuanxiong volatile oil, extraction time is 3-5h.
6. the preparation method of the pharmaceutical composition of promotion union of fracture according to claim 4, is characterized in that, in step (3), described extraction adopts percolation;
Described percolation is with 70%-80% ethanol as solvent, after dipping 45-50h, with the speed percolation of 1 ~ 3ml per minute, collects percolate, is described extracting solution.
7. the preparation method of the pharmaceutical composition of promotion union of fracture according to claim 4, is characterized in that, in step (3), the relative density of described first ointment under the condition of 60 DEG C is 1.20 ~ 1.30.
8. the preparation method of the pharmaceutical composition of promotion union of fracture according to claim 4, is characterized in that, in step (4), the number of times of described decoction is 2-3 time.
9. the preparation method of the pharmaceutical composition of promotion union of fracture according to claim 4, is characterized in that, in step (4), the relative density of described second ointment under the condition of 60 DEG C is 1.20 ~ 1.30.
10. the preparation method of the pharmaceutical composition of the promotion union of fracture according to any one of claim 4-9, is characterized in that, in step (5), described mixture makes any one in granule, capsule, tablet, pill.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106074955A (en) * | 2016-08-24 | 2016-11-09 | 李民功 | A kind of Chinese medicine treating fracture |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319414A (en) * | 2001-01-19 | 2001-10-31 | 刘军 | Medicine for treating hecrosis of femoral head |
| CN102228586A (en) * | 2011-06-27 | 2011-11-02 | 董崇孝 | Ointment for promoting union of bone fractures and preparation method thereof |
| CN103933533A (en) * | 2014-01-23 | 2014-07-23 | 曲宝仁 | Medicine for treating bone fracture caused by falls and contusions |
-
2014
- 2014-12-19 CN CN201410797657.5A patent/CN104435136B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319414A (en) * | 2001-01-19 | 2001-10-31 | 刘军 | Medicine for treating hecrosis of femoral head |
| CN102228586A (en) * | 2011-06-27 | 2011-11-02 | 董崇孝 | Ointment for promoting union of bone fractures and preparation method thereof |
| CN103933533A (en) * | 2014-01-23 | 2014-07-23 | 曲宝仁 | Medicine for treating bone fracture caused by falls and contusions |
Non-Patent Citations (1)
| Title |
|---|
| 焦志国: "生骨丹外敷内服治疗骨折延迟愈合和骨不连的疗效分析", 《中国现代药物应用》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074955A (en) * | 2016-08-24 | 2016-11-09 | 李民功 | A kind of Chinese medicine treating fracture |
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