CN113209213A - Bone-knitting fresh-keeping pill and preparation method thereof - Google Patents
Bone-knitting fresh-keeping pill and preparation method thereof Download PDFInfo
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- CN113209213A CN113209213A CN202110555204.1A CN202110555204A CN113209213A CN 113209213 A CN113209213 A CN 113209213A CN 202110555204 A CN202110555204 A CN 202110555204A CN 113209213 A CN113209213 A CN 113209213A
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Abstract
The invention discloses a bone-knitting fresh-keeping pill, which comprises a main material and an auxiliary material in parts by weight; the main materials comprise 300 portions of baked rhizoma drynariae-; the auxiliary material is 5-15 parts of starch. The bone-knitting and tissue-regeneration pill can achieve the treatment effects of removing blood stasis and promoting tissue regeneration, tonifying liver and kidney and reuniting bones and tendons without an operation, and has no toxic or side effect and good effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a bone-knitting tissue-regeneration pill and a preparation method thereof.
Background
The fracture is a common clinical disease, which is mostly caused by external force, not only brings pain to patients, but also causes a series of complications on clinical manifestations, such as fever, shock, important peripheral tissue injury, important blood vessel injury, and peripheral nerve injury, which are often caused by extensive soft tissue injury, massive hemorrhage, severe pain or complicated visceral injury. Periosteum syndrome, traumatic arthritis, etc. The existing method for treating fracture has the disadvantages of slow healing, long medication time and unsatisfactory curative effect.
At present, most fractures can be normally healed through the treatment of traditional Chinese medicine or western medicine, but the condition that the fractures are slowly healed or even not healed can occur to some fractures, the reasons for the condition are numerous, some fractures are caused by the factors of patients, the factors influenced by medicines are also caused, and even some fractures are not treated properly. At present, western medicine for treating the condition generally carries out treatment through operations, such as bone grafting, fracture end pressurization, electrical stimulation and the like; most of the traditional Chinese medicine takes decoction for treatment. Regardless of the traditional Chinese medicine or western medicine treatment, patients feel pain during the treatment period, and the cost is high, and especially for children, the treatment modes are not preferable, so that the healing time is prolonged, and the pain of the patients is increased.
Senile osteoporosis refers to osteoporosis occurring in postmenopausal women and old people, is a metabolic bone disease, and is clinically mainly manifested by low back pain, short stature, spinal deformation and fracture, which often cause dysfunction of spine and limbs of patients, incapability of self-care in life and finally complications. In recent years, the incidence of senile osteoporosis has been gradually increased, causing various symptoms, which have a serious influence on the quality of life of patients. Therefore, prevention of senile osteoporosis has become an important issue in the current society. The general treatment method is that western medicines apply the bone loss inhibitor and the bone formation promoter, traditional Chinese medicine takes tonifying kidney and spleen and promoting blood circulation to remove blood stasis as treatment principles, adopts ultra-large amount of traditional Chinese medicines and Chinese and western medicines combined with vein and joint cavity injection, and is matched with active function exercise to repair bone destruction and recover joint function at the same time. The existing treatment method has high cost and long period, or other pathological changes are easy to occur in the treatment process, which causes unnecessary pain to the elderly patients.
At present, aspirin, naproxen, nabumetone and the like are mainly used clinically in western medicine for treating hyperosteogeny, certain side effects are generated when the medicines are used for treatment, and certain damage is caused to internal organs in a body after long-term use, so that the treatment difficulty is increased, and certain disadvantages exist in use. The probability of hyperosteogeny recurrence is high, and western medicines mainly cannot improve the internal environment of a patient while treating diseases, so that certain limitation is brought to the treatment of hyperosteogeny. The disease mostly occurs in middle-aged people or old people over 45 years old, men are more than women, and heavy physical workers and athletes frequently used for waist movement are prone to the disease, and are most commonly seen in joints of knees, hips, lumbar vertebrae, cervical vertebrae, elbows and the like.
Chinese medicine has already been for thousands of years for treating fracture, have accumulated the rich experience, think that no matter oral or external medicament has effects of promoting blood circulation, removing blood stasis, detumescence, relieving pain, reunion of fractured bones of reunion of fractured tendons, the kidney-tonifying medicament also has effects of strengthening bone and growing bone. A large number of experimental or clinical research data prove that the fracture healing has pharmaceutical factors, the application of the traditional Chinese medicine has the effect of accelerating the fracture healing, and the research has obtained favorable progress. At present, the fracture is mainly treated by the internal fixation of operative reduction and the external fixation of manual reduction, and is matched with external application medicines, the bed is maintained for a long time, less is kept for a while, more is kept for a few of a while, even if the affected limb can be healed in the future, the joint adhesion caused by long-term bed is also caused, the dysfunction muscle atrophy is caused, and the sequelae caused by the overlong treatment process cause the lifelong pain to the patient. Often has long treatment course, brings pain to patients, is slow to heal, has high cost, long administration time, inconvenient administration and unsatisfactory curative effect, and is easy to leave sequelae. In view of the above, it is necessary to design a new bone-knitting pill and a preparation method thereof.
Disclosure of Invention
The invention aims to provide a bone-knitting and tissue-regeneration pill and a preparation method thereof, which can treat various fractures, dislocation, muscle injuries, delayed union of fractures, senile osteoporosis and kidney deficiency type hyperosteogeny, can achieve the treatment effects of removing blood stasis and promoting tissue regeneration, tonifying liver and kidney and reuniting bones and tendons without an operation, and has no toxic or side effect and good effect.
In order to achieve the purpose, the invention provides a bone-knitting fresh-keeping pill which comprises a main material and an auxiliary material in parts by weight;
the main materials comprise 350 parts of baked rhizoma drynariae, 300 parts of 200 parts of salted eucommia bark, 225 parts of wine teasel root, 150 parts of angelica, 75-100 parts of pseudo-ginseng, 200 parts of salvia miltiorrhiza, 200 parts of astragalus, 200 parts of salted psoralea fruit, 200 parts of baked rhizoma cibotii, 200 parts of cortex acanthopanacis, 200 parts of yam, 200 parts of achyranthes bidentata, 200 parts of loranthus, 200 parts of radix clematidis, 200 parts of ground beetle, 200 parts of dried rehmannia root, 150 parts of dried rehmannia root and 75-100 parts of dragon's blood;
the auxiliary material is 5-15 parts of starch.
Preferably, the feed comprises main materials and auxiliary materials in parts by weight;
the main materials comprise 300 parts of scalded rhizoma drynariae, 200 parts of salted eucommia bark, 175 parts of wine teasel root, 150 parts of angelica, 75 parts of pseudo-ginseng, 150 parts of salvia miltiorrhiza, 150 parts of astragalus, 150 parts of salted fructus psoraleae, 150 parts of scalded rhizoma cibotii, 150 parts of cortex acanthopanacis, 150 parts of Chinese yam, 150 parts of achyranthes root, 150 parts of parasitic loranthus, 150 parts of radix clematidis, 150 parts of ground beetle, 150 parts of radix rehmanniae recen and 75 parts of dragon's blood;
the auxiliary material is 15 parts of starch.
Preferably, the feed comprises main materials and auxiliary materials in parts by weight;
the main materials comprise 333 parts of scalded rhizoma drynariae, 250 parts of salted eucommia bark, 200 parts of wine teasel root, 167 parts of angelica, 83 parts of pseudo-ginseng, 167 parts of salvia miltiorrhiza, 167 parts of astragalus, 167 parts of salted fructus psoraleae, 167 parts of scalded rhizoma cibotii, 167 parts of cortex acanthopanacis, 167 parts of Chinese yam, 167 parts of radix achyranthis bidentatae, 167 parts of parasitic loranthus, 167 parts of radix clematidis, 167 parts of ground beetle, 167 parts of radix rehmanniae and 83 parts of dragon's blood;
the auxiliary material is 7 parts of starch.
Preferably, the feed comprises main materials and auxiliary materials in parts by weight;
the main materials comprise 350 parts of scalded rhizoma drynariae, 300 parts of salted eucommia bark, 225 parts of wine teasel root, 200 parts of angelica, 100 parts of pseudo-ginseng, 200 parts of salvia miltiorrhiza, 200 parts of astragalus, 200 parts of salted fructus psoraleae, 200 parts of scalded rhizoma cibotii, 200 parts of cortex acanthopanacis, 200 parts of Chinese yam, 200 parts of achyranthes root, 200 parts of parasitic loranthus, 200 parts of radix clematidis, 200 parts of ground beetle, 200 parts of radix rehmanniae recen and 100 parts of dragon's blood;
the auxiliary material is 5 parts of starch.
A preparation method of bone-knitting fresh-keeping pills comprises the following steps:
a) weighing the main materials and the auxiliary materials according to the proportion, removing impurities, and cleaning for later use;
b) placing Notoginseng radix and sanguis Draxonis in clean pulverizer, pulverizing to powder of no less than 100 mesh, sterilizing, and sealing for storage;
c) cutting the rest fifteen main materials into decoction pieces, placing into a clean extraction tank, adding water, decocting and extracting twice, heating and boiling for extracting for 1 hour for the first time, heating and boiling for extracting for 1 hour for the second time, filtering, discarding the residues, combining the filtrates, decocting, mixing, pumping into a single-effect evaporation concentrator, concentrating under reduced pressure to obtain a thick paste with a relative density of 1.20-1.25 and a temperature of 60 ℃, and cooling to normal temperature to obtain a concentrated solution for later use;
d) pumping the concentrated solution obtained in the step c) into a clean vacuum drying oven, carrying out vacuum drying to prepare dry extract, then putting the dry extract into a clean pulverizer, and carrying out pulverizing operation to ensure that the powder of the dry extract is not less than 100 meshes and the water content is not more than 5 percent, and hermetically storing for later use;
e) fully stirring and uniformly mixing the dry extract powder obtained in the step d), the fine powder obtained in the step b) and auxiliary material starch according to a proportion, making pills, and drying to obtain the Chinese medicinal composition.
The pharmacological actions of various raw materials of the invention are as follows:
scalded rhizoma drynariae, nature and taste: bitter and warm. Meridian tropism: it enters liver and kidney meridians. The efficacy is as follows: treating wound, relieving pain, invigorating kidney, and strengthening bone; dispel wind and remove spots for external use. The main treatment is as follows: can be used for treating traumatic injury, sprain, fracture, lumbago due to kidney deficiency, flaccidity of bones and muscles, tinnitus, deafness, and odontoseisis; it is indicated for alopecia areata and white scar.
Salted eucommia bark, nature and taste: sweet and warm. Meridian tropism: it enters liver and kidney meridians. The efficacy is as follows: tonify liver and kidney, strengthen tendons and bones, prevent abortion. The main treatment is as follows: can be used for treating deficiency of liver and kidney, soreness of waist and knees, weakness of bones and muscles, dizziness, pregnant hemorrhage, and threatened abortion.
Teasel root processed with wine, nature and taste: bitter and pungent with mild warm nature. Meridian tropism: it enters liver and kidney meridians. The functions are as follows: tonify liver and kidney, strengthen tendons and bones, continue fracture and stop metrorrhagia and metrostaxis. The main treatment is as follows: can be used for treating deficiency of liver and kidney, soreness of waist and knees, rheumatalgia, traumatic injury, injury of tendons and bones, metrorrhagia, and fetal leakage. The wine prepared teasel root is mainly used for treating rheumatism, arthralgia, traumatic injury, tendon injury and fracture.
Angelica sinensis, nature and taste: sweet, pungent and warm. Meridian tropism: it enters liver, heart and spleen meridians. The functions are as follows: tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. The main treatment is as follows: can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Pseudo-ginseng, nature and taste: sweet, slightly bitter and warm. Meridian tropism: it enters liver and stomach meridians. The functions are as follows: disperse blood stasis, stop bleeding, resolve swelling and alleviate pain. The main treatment is as follows: can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.
Red sage root, nature and taste: bitter and slightly cold. Meridian tropism: it enters heart and liver meridians. The functions are as follows: promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle. The main treatment is as follows: can be used for treating thoracic obstruction, cardialgia, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Astragalus root, nature and taste: sweet and warm. Meridian tropism: it enters lung and spleen meridians. The functions are as follows: invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, expelling toxin, expelling pus, healing sore, and promoting granulation. The main treatment is as follows: can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, spontaneous perspiration due to exterior deficiency, edema due to qi deficiency, internal heat, diabetes, blood deficiency, hemiplegia, arthralgia, numbness, carbuncle, cellulitis, and intractable ulcer.
Fructus psoraleae, nature and taste: pungent, bitter and warm. Meridian tropism: it enters kidney and spleen meridians. The functions are as follows: warming kidney and supporting yang, receiving qi and relieving asthma, warming spleen and relieving diarrhea; dispel wind and remove spots for external use. The main treatment is as follows: can be used for treating kidney yang deficiency, sexual impotence, spermatorrhea, enuresis, frequent micturition, lumbago, knee pain, asthma due to kidney deficiency, and morning diarrhea; it is used externally to treat vitiligo and alopecia areata.
Scalded cibotium rhizome, nature and taste: bitter, sweet and warm. Meridian tropism: it enters liver and kidney meridians. The functions are as follows: dispel wind-damp, tonify liver and kidney, strengthen waist and knees. The main treatment is as follows: can be used for treating rheumatalgia, soreness of waist and knees, and weakness of lower limbs.
Cortex acanthopanacis, nature and taste: pungent, bitter and warm. Meridian tropism: it enters liver and kidney meridians. The functions are as follows: dispelling pathogenic wind and removing dampness, invigorating liver and kidney, strengthening tendons and bones, and inducing diuresis to alleviate edema. The main treatment is as follows: can be used for treating rheumatism, flaccidity of bones and muscles, infantile retardation, asthenia, edema, and tinea pedis.
Yam, nature and taste: sweet and neutral. Meridian tropism: it enters spleen, lung and kidney meridians. The functions are as follows: tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. The main treatment is as follows: can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat.
Achyranthes bidentata, property and taste: bitter, sweet, sour and neutral. Meridian tropism: it enters liver and kidney meridians. The functions are as follows: dispel blood stasis and dredge channels, tonify liver and kidney, strengthen tendons and bones, induce diuresis and treat stranguria, and draw blood downward. The main treatment is as follows: can be used for treating amenorrhea, dysmenorrhea, soreness of waist and knees, myasthenia of bones and muscles, stranguria, edema, headache, vertigo, toothache, aphtha, hematemesis, and epistaxis.
Mistletoe, nature and taste: bitter, sweet and neutral. Meridian tropism: it enters liver and kidney meridians. The functions are as follows: dispel wind-damp, tonify liver and kidney, strengthen tendons and bones, and prevent abortion. The main treatment is as follows: can be used for treating rheumatalgia, soreness of waist and knees, weakness of bones and muscles, metrorrhagia, metrostaxis, pregnant hemorrhage, threatened abortion, and dizziness.
Clematis root, nature and taste: pungent, salty and warm. Meridian tropism: it enters bladder meridian. The functions are as follows: dispel wind-damp, unblock collaterals. The main treatment is as follows: can be used for treating rheumatalgia, numbness of limbs, spasm of tendons and vessels, and difficulty in flexion and extension.
Ground beetle, nature and taste: salty and cold; has little toxicity. Meridian tropism: it enters liver meridian. The functions are as follows: break blood and remove stasis, reunion of fractured tendons and bones. The main treatment is as follows: can be used for treating traumatic injury, injury of tendons and bones, amenorrhea due to blood stasis, puerperal abdominal pain due to blood stasis, and abdominal mass.
Dried rehmannia root, nature and taste: sweet and cold in nature. Meridian tropism: it enters heart, liver and kidney meridians. The functions are as follows: clear heat and cool blood, nourish yin and promote the production of body fluid. The main treatment is as follows: can be used for treating heat entering nutrient-blood, epidemic febrile disease, macula, hematemesis, epistaxis, yin injury due to fever, crimson tongue, polydipsia, constipation due to body fluid consumption, fever due to yin deficiency, bone steaming, fatigue, internal heat, and diabetes.
Dragon's blood, nature and taste: sweet, pungent, salty and neutral. Meridian tropism: it enters lung, spleen and kidney meridians. The functions are as follows: promoting blood circulation, removing blood stasis, relieving pain, stopping bleeding, healing wound, and promoting granulation. The main treatment is as follows: can be used for treating traumatic injury, pain due to blood stasis, stagnation of qi and blood, traumatic hemorrhage, and intractable abscess.
The compatibility principle of the medicines is as follows:
after the early treatment of the fracture, the stagnation of qi is gradually eliminated along with the blood stasis, but the swelling and the stasis are not eliminated, the broken bones are not connected, or the broken bones are not firmly connected initially, so that the fracture is mainly treated by harmonizing nutrient and promoting tissue regeneration, nourishing the liver and kidney, strengthening muscles and bones, and promoting blood circulation and removing blood stasis, and relaxing tendons and activating collaterals to benefit joints. The scalded rhizoma drynariae, salted eucommia bark, wine teasel root, achyranthes root, angelica and astragalus root are used as monarch drugs for benefiting qi and nourishing blood; fructus Psoraleae, rhizoma Cibotii, and radix Clematidis for reunion of bone and tendon, which are used as ministerial drugs; radix salviae miltiorrhizae, pseudo-ginseng, dragon's blood, ground beeltle and radix rehmanniae are used as adjuvants for promoting qi circulation, activating blood circulation and removing blood stasis; the combination of yam, cortex acanthopanacis and loranthus parasiticus is used as a guiding drug for warming and activating meridian, dispelling wind and eliminating dampness. The medicines are combined to tonify liver and kidney, strengthen tendons and bones, promote blood circulation to remove blood stasis, accelerate fracture healing as soon as possible and generate new bones.
The bone-knitting new pill has the beneficial effects that:
the bone-knitting and tissue-regeneration pill has the effects of removing blood stasis and promoting tissue regeneration, tonifying liver and kidney and reuniting bones and tendons, has special effects of treating various fractures, dislocation and muscle injuries, delayed union of fractures, senile osteoporosis and kidney deficiency type hyperosteogeny, is convenient to take, and brings good news to a plurality of fracture patients.
The bone-knitting fresh-keeping pill has definite curative effect, low price, economy and easy acceptance by patients, embodies the advantages of treating bone diseases by traditional Chinese medicine and has good economic benefit.
The application and dosage of the invention for treating various fractures, dislocation, muscle injuries, delayed union of fractures, senile osteoporosis and kidney deficiency type hyperosteogeny are as follows: orally administered 2 bags at a time, 2 times a day, or following a physician's advice.
The bone-knitting new-tissue pill of the invention has the following treatment indications: fracture, dislocation, tendon injury, delayed union of fracture, senile osteoporosis and kidney deficiency type hyperosteogeny.
Therefore, the bone-knitting and tissue-regeneration pill and the preparation method thereof can treat various fractures, dislocation, muscle injuries, delayed union of fractures, senile osteoporosis and kidney deficiency type hyperosteogeny, can achieve the treatment effects of removing blood stasis and promoting tissue regeneration, tonifying liver and kidney and reuniting bones and tendons without operation, and have no toxic or side effect and good effect.
The technical solution of the present invention is further described in detail by the following examples.
Detailed Description
The technical solution of the present invention is further illustrated by the following examples.
The invention provides a bone-knitting fresh-keeping pill, which comprises a main material and an auxiliary material in parts by weight;
the main materials comprise 350 parts of baked rhizoma drynariae, 300 parts of 200 parts of salted eucommia bark, 225 parts of wine teasel root, 150 parts of angelica, 75-100 parts of pseudo-ginseng, 200 parts of salvia miltiorrhiza, 200 parts of astragalus, 200 parts of salted psoralea fruit, 200 parts of baked rhizoma cibotii, 200 parts of cortex acanthopanacis, 200 parts of yam, 200 parts of achyranthes bidentata, 200 parts of loranthus, 200 parts of radix clematidis, 200 parts of ground beetle, 200 parts of dried rehmannia root, 150 parts of dried rehmannia root and 75-100 parts of dragon's blood;
the auxiliary material is 5-15 parts of starch.
A preparation method of bone-knitting fresh-keeping pills comprises the following steps:
a) weighing the main materials and the auxiliary materials according to the proportion, removing impurities, and cleaning for later use;
b) placing Notoginseng radix and sanguis Draxonis in clean pulverizer, pulverizing to powder of no less than 100 mesh, sterilizing, and sealing for storage;
c) cutting the rest fifteen main materials into decoction pieces, placing into a clean extraction tank, adding water, decocting and extracting twice, heating and boiling for extracting for 1 hour for the first time, heating and boiling for extracting for 1 hour for the second time, filtering, discarding the residues, combining the filtrates, decocting, mixing, pumping into a single-effect evaporation concentrator, concentrating under reduced pressure to obtain a thick paste with a relative density of 1.20-1.25 and a temperature of 60 ℃, and cooling to normal temperature to obtain a concentrated solution for later use;
d) pumping the concentrated solution obtained in the step c) into a clean vacuum drying oven, carrying out vacuum drying to prepare dry extract, then putting the dry extract into a clean pulverizer, and carrying out pulverizing operation to ensure that the powder of the dry extract is not less than 100 meshes and the water content is not more than 5 percent, and hermetically storing for later use;
e) fully stirring and uniformly mixing the dry extract powder obtained in the step d), the fine powder obtained in the step b) and auxiliary material starch according to a proportion, making pills, and drying to obtain the Chinese medicinal composition.
Example 1
The invention provides a bone-knitting fresh-keeping pill, which comprises a main material and an auxiliary material in parts by weight;
main materials: 300 parts of scalded rhizoma drynariae, 200 parts of salted eucommia bark, 175 parts of wine teasel root, 150 parts of angelica, 75 parts of pseudo-ginseng, 150 parts of salvia miltiorrhiza, 150 parts of astragalus, 150 parts of salted fructus psoraleae, 150 parts of scalded rhizoma cibotii, 150 parts of cortex acanthopanacis, 150 parts of Chinese yam, 150 parts of achyranthes root, 150 parts of parasitic loranthus, 150 parts of radix clematidis, 150 parts of ground beetle, 150 parts of radix rehmanniae recen and 75 parts of dragon's blood;
15 parts of starch as an auxiliary material.
A preparation method of bone-knitting fresh-keeping pills comprises the following steps:
a) weighing the pure medicinal materials with impurities removed according to the proportion for later use;
b) placing Notoginseng radix and sanguis Draxonis in clean pulverizer, pulverizing to powder of no less than 100 mesh (fine powder), sterilizing, and sealing;
c) cutting the rest fifteen clean medicinal materials such as the scalded rhizoma drynariae and the like into decoction pieces, placing the decoction pieces into a clean extraction tank, adding water for decoction and extraction twice, heating and boiling for extraction for 1 hour for the first time, heating and boiling for extraction for 1 hour for the second time, filtering, discarding medicine residues, combining decoction filtrates, uniformly mixing, pumping into a single-effect evaporation concentrator, concentrating under reduced pressure to obtain thick paste with the relative density of 1.20-1.25(60 ℃), and cooling to normal temperature for later use;
d) pumping the concentrated solution obtained in the step c) into a clean vacuum drying oven, carrying out vacuum drying to prepare dry extract, then putting the dry extract into a clean pulverizer, carrying out pulverizing operation to ensure that the dry extract powder is not less than 100 meshes (fine powder) and the water content is not more than 5 percent, and hermetically storing for later use;
e) fully stirring and uniformly mixing the dry extract powder obtained in the step d), the fine powder obtained in the step b) and auxiliary material starch according to a proportion, and preparing pills and drying to obtain the Chinese medicinal composition;
example 2
The invention provides a bone-knitting fresh-keeping pill, which comprises a main material and an auxiliary material in parts by weight;
main materials: 333 parts of scalded rhizoma drynariae, 250 parts of salted eucommia bark, 200 parts of wine teasel root, 167 parts of Chinese angelica, 83 parts of pseudo-ginseng, 167 parts of red sage root, 167 parts of astragalus root, 167 parts of salted malaytea scurfpea fruit, 167 parts of scalded rhizoma cibotii, 167 parts of cortex acanthopanacis, 167 parts of Chinese yam, 167 parts of achyranthes root, 167 parts of parasitic loranthus, 167 parts of radix clematidis, 167 parts of ground beetle, 167 parts of dried rehmannia root and 83 parts of dragon's blood;
auxiliary materials: 7 parts of starch.
A preparation method of bone-knitting fresh-keeping pills comprises the following steps:
a) weighing the pure medicinal materials with impurities removed according to the proportion for later use;
b) placing Notoginseng radix and sanguis Draxonis in clean pulverizer, pulverizing to powder of no less than 100 mesh (fine powder), sterilizing, and sealing;
c) cutting the rest fifteen clean medicinal materials such as the scalded rhizoma drynariae and the like into decoction pieces, placing the decoction pieces into a clean extraction tank, adding water for decoction and extraction twice, heating and boiling for extraction for 1 hour for the first time, heating and boiling for extraction for 1 hour for the second time, filtering, discarding medicine residues, combining decoction filtrates, uniformly mixing, pumping into a single-effect evaporation concentrator, concentrating under reduced pressure to obtain thick paste with the relative density of 1.20-1.25(60 ℃), and cooling to normal temperature for later use;
d) pumping the concentrated solution obtained in the step c) into a clean vacuum drying oven, carrying out vacuum drying to prepare dry extract, then putting the dry extract into a clean pulverizer, carrying out pulverizing operation to ensure that the dry extract powder is not less than 100 meshes (fine powder) and the water content is not more than 5 percent, and hermetically storing for later use;
e) fully stirring and uniformly mixing the dry extract powder obtained in the step d), the fine powder obtained in the step b) and auxiliary material starch according to a proportion, making pills, and drying to obtain the Chinese medicinal composition.
Example 3
The invention provides a bone-knitting fresh-keeping pill, which comprises a main material and an auxiliary material in parts by weight;
main materials: 350 parts of scalded rhizoma drynariae, 300 parts of salted eucommia bark, 225 parts of wine teasel root, 200 parts of angelica, 100 parts of pseudo-ginseng, 200 parts of salvia miltiorrhiza, 200 parts of astragalus, 200 parts of salted fructus psoraleae, 200 parts of scalded rhizoma cibotii, 200 parts of cortex acanthopanacis, 200 parts of Chinese yam, 200 parts of achyranthes root, 200 parts of parasitic loranthus, 200 parts of radix clematidis, 200 parts of ground beetle, 200 parts of radix rehmanniae recen and 100 parts of dragon's blood;
5 parts of starch as an auxiliary material.
A preparation method of bone-knitting fresh-keeping pills comprises the following steps:
a) weighing the pure medicinal materials with impurities removed according to the proportion for later use;
b) placing Notoginseng radix and sanguis Draxonis in clean pulverizer, pulverizing to powder of no less than 100 mesh (fine powder), sterilizing, and sealing;
c) cutting the rest fifteen clean medicinal materials such as the scalded rhizoma drynariae and the like into decoction pieces, placing the decoction pieces into a clean extraction tank, adding water for decoction and extraction twice, heating and boiling for extraction for 1 hour for the first time, heating and boiling for extraction for 1 hour for the second time, filtering, discarding medicine residues, combining decoction filtrates, uniformly mixing, pumping into a single-effect evaporation concentrator, concentrating under reduced pressure to obtain thick paste with the relative density of 1.20-1.25(60 ℃), and cooling to normal temperature for later use;
d) pumping the concentrated solution obtained in the step c) into a clean vacuum drying oven, carrying out vacuum drying to prepare dry extract, then putting the dry extract into a clean pulverizer, carrying out pulverizing operation to ensure that the dry extract powder is not less than 100 meshes (fine powder) and the water content is not more than 5 percent, and hermetically storing for later use;
e) fully stirring and uniformly mixing the dry extract powder obtained in the step d), the fine powder obtained in the step b) and auxiliary material starch according to a proportion, making pills, and drying to obtain the Chinese medicinal composition.
The bone-knitting fresh-keeping pill of the invention is a new medicine component, take scalded rhizoma drynariae, salted cortex eucommiae, wine radix dipsaci, Angelica sinensis, etc. seventeen medicinal materials as raw materials composing prescription and use modern scientific, advanced industrialized preparation method; provides a bone-knitting and tissue-regeneration pill for treating various fractures, dislocation, muscle injuries, delayed union of fractures, senile osteoporosis and kidney deficiency type hyperosteogeny and a preparation method thereof. The preparation has high safety, small side effect and remarkable curative effect, overcomes the defects in western medicine treatment in the aspects of preventing and treating fracture, dislocation, muscle injury, delayed fracture healing, senile osteoporosis and kidney deficiency type hyperosteogeny, develops the advantages of Chinese medicine, exerts the synergistic effect by combining Chinese medicine and western medicine, achieves the aim of treating both principal and secondary aspects of disease, improves the clinical curative effect and relieves the pain of patients.
The bone-knitting fresh-keeping pill prepared according to the formula is applied clinically, and has good effect, and the specific clinical cases are as follows:
case 1: female, age 40 years. The left 2-5 indicates that the pain and bleeding caused by the iron wire is limited for more than 1 hour. The left middle finger has obvious swelling, active wound bleeding, limited activity and poor feeling through examination. The left middle and distal finger pulp is damaged, the flexor tendon is exposed, the nail bed and the phalanx are exposed with defects, the left middle and distal finger pulp is damaged, the flexor tendon is exposed, the epidermis of the left ring finger pulp is damaged, the left middle and distal finger pulp is damaged, the left ulnar side is damaged, the left hand activity is limited, the pollution is serious, and the bleeding of each wound is active. After hospital examination, performing left-handed debridement, angioneurotic tendon exploration and repair and VDS negative pressure drainage, and performing infection prevention and swelling reduction after operation, so that the formula is used for preventing infection and swelling reduction, and the main materials are as follows: 333 parts of scalded rhizoma drynariae, 250 parts of salted eucommia bark, 200 parts of wine teasel root, 167 parts of Chinese angelica, 83 parts of pseudo-ginseng, 167 parts of red sage root, 167 parts of astragalus root, 167 parts of salted malaytea scurfpea fruit, 167 parts of scalded rhizoma cibotii, 167 parts of cortex acanthopanacis, 167 parts of Chinese yam, 167 parts of achyranthes root, 167 parts of parasitic loranthus, 167 parts of radix clematidis, 167 parts of ground beetle, 167 parts of dried rehmannia root and 83 parts of dragon's blood; auxiliary materials: 7 parts of starch. The medicine is taken 7 times a day, and the medicine decocting machine is used for decocting the medicine and water is used for decoction. Discharge time condition: the patient has clear spirit, normal body temperature, pulse, respiration and blood pressure and good general condition, the wounds of each finger and the wrist of the left hand are well healed, the left hand is dry and does not have exudation, the tail end of the left indicating finger is slightly incomplete, and the disease condition is stable.
Case 2: male, 52 years old. The pain of the first and second toes of the right foot is injured by heavy objects, the movement is not good for more than 12 days, and the fracture of the first and second phalanges of the right foot is checked, and the alignment of the broken ends is correct. The plaster is used for external fixation treatment, and then the Xinshang xuan decoction is added and subtracted by the traditional Chinese medicine of the invention, and the main materials are as follows: 350 parts of scalded rhizoma drynariae, 300 parts of salted eucommia bark, 225 parts of wine teasel root, 200 parts of angelica, 100 parts of pseudo-ginseng, 200 parts of salvia miltiorrhiza, 200 parts of astragalus, 200 parts of salted fructus psoraleae, 200 parts of scalded rhizoma cibotii, 200 parts of cortex acanthopanacis, 200 parts of Chinese yam, 200 parts of achyranthes root, 200 parts of parasitic loranthus, 200 parts of radix clematidis, 200 parts of ground beetle, 200 parts of radix rehmanniae recen and 100 parts of dragon's blood; 5 parts of starch as an auxiliary material. The traditional Chinese medicine is taken with water after 7 doses of the traditional Chinese medicine every day. The swelling of the right foot subsides earlier, the tenderness is relieved earlier, the artery of the dorsum of the foot is pulsating, and the blood circulation sense of the tail end of the right foot is good and the right foot can move.
Case 3: male, 7 years old and 7 months old. The patient carelessly falls down when playing at home to cause pain, swelling and limited activity for more than 1 week after the left upper limb is landed. Examination shows that the left ulna and radius middle section is fractured, the broken end bottom is blunt and angled, the wrist joint gap is normal, manual reduction and Shiken external fixation are immediately performed, then the newly injured teasel root decoction is added and reduced by using the traditional Chinese medicine, 3 times of traditional Chinese medicines are used, one time every day, a decoction machine is used for decocting, water is used for decocting, and the left upper limb moves freely.
Case 4: female, age 78 years. The pain of the waist and the right lower limb caused by careless injury is a week, the chest lumbar vertebra curvature is later convex after diagnosis, the movement of the chest lumbar vertebra is limited, the muscles of the chest lumbar back are tense, the spinous process of L4 and the pressing and tapping pain at two sides are not painful, the pain is not radiated, the chest lumbar back pain can be induced by the turnover movement, the right knee pain is limped, the right knee swelling is obvious, and the disease differentiation of the traditional Chinese medicine is as follows: fracture, the old female of the patient, suffer from external force causing local bone muscle and tendon injury, the bone and muscle damage outside, then qi and blood injure inside, qi and blood are not harmonized, the circulation is not smooth, blood stasis and qi stagnation are caused, the obstruction leads to pain, so the pain is caused. Tendon injury: muscle injuries are usually caused by traumatic injuries, violent traumas, strain or cold-dampness exogenous pathogenic factors, and are manifested as local pain, swelling and restricted movement. MRI showed no abnormality in bone mass. The patient is injured by external force, so that local qi and blood circulation is not smooth to cause pain, and MRI shows that L1 fracture can be identified: bone impediment: both of them can manifest pain in the waist and are closely related to the kidneys. Bone impediment is mostly caused by wind-cold-dampness invasion of bones in winter, and clinically, rheumatism characterized by limb joint pain, limited movement, heavy bones and soreness and weakness of waist and knees is mostly caused by kidney yang deficiency and wind-cold-dampness invasion of kidney yang. The patient has obvious history of trauma and can be identified. After the operation treatment, the traditional Chinese medicine is used for treating, the traditional Chinese medicine takes the methods of promoting blood circulation, dredging collaterals, tonifying liver and kidney and strengthening bones and muscles as the treatment, the patient is an elderly patient, the patient needs to lie in bed for 3 months for conservative treatment, the traditional Chinese medicine is used for treating, and the main materials are as follows: 333 parts of scalded rhizoma drynariae, 250 parts of salted eucommia bark, 200 parts of wine teasel root, 167 parts of Chinese angelica, 83 parts of pseudo-ginseng, 167 parts of red sage root, 167 parts of astragalus root, 167 parts of salted malaytea scurfpea fruit, 167 parts of scalded rhizoma cibotii, 167 parts of cortex acanthopanacis, 167 parts of Chinese yam, 167 parts of achyranthes root, 167 parts of parasitic loranthus, 167 parts of radix clematidis, 167 parts of ground beetle, 167 parts of dried rehmannia root and 83 parts of dragon's blood; auxiliary materials: 7 parts of starch. The traditional Chinese medicine is taken with 14 doses each day. The symptoms are obviously relieved, and the incision grows well without red swelling.
In case 5, female, age 70, chest, waist and back pain due to sprain for a week, failure of rising, bulging of intervertebral disc, and degeneration of lumbar and lumbar intervertebral discs. The traditional Chinese medicine diagnoses the fracture disease-qi stagnation and blood stasis. After surgery, the bone-knitting soup of the traditional Chinese medicine prescription disclosed by the invention is used for knitting bones and continuing to injure, and the main materials are as follows: 333 parts of scalded rhizoma drynariae, 250 parts of salted eucommia bark, 200 parts of wine teasel root, 167 parts of Chinese angelica, 83 parts of pseudo-ginseng, 167 parts of red sage root, 167 parts of astragalus root, 167 parts of salted malaytea scurfpea fruit, 167 parts of scalded rhizoma cibotii, 167 parts of cortex acanthopanacis, 167 parts of Chinese yam, 167 parts of achyranthes root, 167 parts of parasitic loranthus, 167 parts of radix clematidis, 167 parts of ground beetle, 167 parts of dried rehmannia root and 83 parts of dragon's blood; auxiliary materials: 7 parts of starch. The Chinese medicines are 7 times, one dose is taken every day, and the decoction machine is used for decocting and taking the decoction. The formula mainly takes the strong blood-breaking products of pseudo-ginseng, dragon's blood and safflower to strengthen the action of promoting blood circulation and removing blood stasis; the sweet and warm salvia miltiorrhiza, the radix rehmanniae and the angelica sinensis nourish yin and liver, nourish blood and regulate menstruation, and the peony nourishes blood and nourishes nutrient to increase the blood replenishing capability; rhizoma Ligustici Chuanxiong has effects of promoting blood circulation, activating qi-flowing, and regulating qi and blood, and rhizoma Drynariae, Eucommiae cortex, radix Dipsaci, rhizoma Cibotii, and Achyranthis radix have effects of nourishing liver and kidney, strengthening tendons and bones, and promoting fracture healing. The whole formula has proper compatibility, so that extravasated blood is removed, new blood is generated, qi activity is smooth, and fracture is healed. After the medicine is taken, the symptoms are obviously relieved, the pain of the chest, the waist and the back is obviously relieved, the movement of the chest, the waist and the back is obviously improved, and the wound is good and has no red swelling.
Therefore, the bone-knitting and tissue-regeneration pill and the preparation method thereof can treat various fractures, dislocation, muscle injuries, delayed union of fractures, senile osteoporosis and kidney deficiency type hyperosteogeny, can achieve the treatment effects of removing blood stasis and promoting tissue regeneration, tonifying liver and kidney and reuniting bones and tendons without operation, and have no toxic or side effect and good effect.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that: modifications and equivalents may be made to the invention without departing from the spirit and scope of the invention.
Claims (5)
1. A bone-knitting fresh-keeping pill is characterized in that: comprises main materials and auxiliary materials in parts by weight;
the main materials comprise 350 parts of baked rhizoma drynariae, 300 parts of 200 parts of salted eucommia bark, 225 parts of wine teasel root, 150 parts of angelica, 75-100 parts of pseudo-ginseng, 200 parts of salvia miltiorrhiza, 200 parts of astragalus, 200 parts of salted psoralea fruit, 200 parts of baked rhizoma cibotii, 200 parts of cortex acanthopanacis, 200 parts of yam, 200 parts of achyranthes bidentata, 200 parts of loranthus, 200 parts of radix clematidis, 200 parts of ground beetle, 200 parts of dried rehmannia root, 150 parts of dried rehmannia root and 75-100 parts of dragon's blood;
the auxiliary material is 5-15 parts of starch.
2. The bone-knitting fresh-keeping pill as claimed in claim 1, which is characterized in that: comprises main materials and auxiliary materials in parts by weight;
the main materials comprise 300 parts of scalded rhizoma drynariae, 200 parts of salted eucommia bark, 175 parts of wine teasel root, 150 parts of angelica, 75 parts of pseudo-ginseng, 150 parts of salvia miltiorrhiza, 150 parts of astragalus, 150 parts of salted fructus psoraleae, 150 parts of scalded rhizoma cibotii, 150 parts of cortex acanthopanacis, 150 parts of Chinese yam, 150 parts of achyranthes root, 150 parts of parasitic loranthus, 150 parts of radix clematidis, 150 parts of ground beetle, 150 parts of radix rehmanniae recen and 75 parts of dragon's blood;
the auxiliary material is 15 parts of starch.
3. The bone-knitting fresh-keeping pill as claimed in claim 2, characterized in that: comprises main materials and auxiliary materials in parts by weight;
the main materials comprise 333 parts of scalded rhizoma drynariae, 250 parts of salted eucommia bark, 200 parts of wine teasel root, 167 parts of angelica, 83 parts of pseudo-ginseng, 167 parts of salvia miltiorrhiza, 167 parts of astragalus, 167 parts of salted fructus psoraleae, 167 parts of scalded rhizoma cibotii, 167 parts of cortex acanthopanacis, 167 parts of Chinese yam, 167 parts of radix achyranthis bidentatae, 167 parts of parasitic loranthus, 167 parts of radix clematidis, 167 parts of ground beetle, 167 parts of radix rehmanniae and 83 parts of dragon's blood;
the auxiliary material is 7 parts of starch.
4. The bone-knitting fresh-keeping pill as claimed in claim 3, which is characterized in that: comprises main materials and auxiliary materials in parts by weight;
the main materials comprise 350 parts of scalded rhizoma drynariae, 300 parts of salted eucommia bark, 225 parts of wine teasel root, 200 parts of angelica, 100 parts of pseudo-ginseng, 200 parts of salvia miltiorrhiza, 200 parts of astragalus, 200 parts of salted fructus psoraleae, 200 parts of scalded rhizoma cibotii, 200 parts of cortex acanthopanacis, 200 parts of Chinese yam, 200 parts of achyranthes root, 200 parts of parasitic loranthus, 200 parts of radix clematidis, 200 parts of ground beetle, 200 parts of radix rehmanniae recen and 100 parts of dragon's blood;
the auxiliary material is 5 parts of starch.
5. The preparation method of bone-knitting fresh pills according to any one of claims 1 to 4, which is characterized by comprising the following steps:
a) weighing the main materials and the auxiliary materials according to the proportion, removing impurities, and cleaning for later use;
b) placing Notoginseng radix and sanguis Draxonis in clean pulverizer, pulverizing to powder of no less than 100 mesh, sterilizing, and sealing for storage;
c) cutting the rest fifteen main materials into decoction pieces, placing into a clean extraction tank, adding water, decocting and extracting twice, heating and boiling for extracting for 1 hour for the first time, heating and boiling for extracting for 1 hour for the second time, filtering, discarding the residues, combining the filtrates, decocting, mixing, pumping into a single-effect evaporation concentrator, concentrating under reduced pressure to obtain a thick paste with a relative density of 1.20-1.25 and a temperature of 60 ℃, and cooling to normal temperature to obtain a concentrated solution for later use;
d) pumping the concentrated solution obtained in the step c) into a clean vacuum drying oven, carrying out vacuum drying to prepare dry extract, then putting the dry extract into a clean pulverizer, and carrying out pulverizing operation to ensure that the powder of the dry extract is not less than 100 meshes and the water content is not more than 5 percent, and hermetically storing for later use;
e) fully stirring and uniformly mixing the dry extract powder obtained in the step d), the fine powder obtained in the step b) and auxiliary material starch according to a proportion, making pills, and drying to obtain the Chinese medicinal composition.
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Non-Patent Citations (2)
| Title |
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| 周文华: "愈伤颗粒剂治疗股骨粗隆间骨折内固定术后30例总结", 《湖南中医杂志》 * |
| 桂军明: "中西医结合治疗胫腓骨骨折愈合迟缓40例", 《实用中医药杂志》 * |
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