CN104434556B - A kind of hand cleanser containing glucosides and its derivative - Google Patents
A kind of hand cleanser containing glucosides and its derivative Download PDFInfo
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- CN104434556B CN104434556B CN201410631140.9A CN201410631140A CN104434556B CN 104434556 B CN104434556 B CN 104434556B CN 201410631140 A CN201410631140 A CN 201410631140A CN 104434556 B CN104434556 B CN 104434556B
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Abstract
The present invention relates to a kind of hand cleanser containing glucosides and its derivative, belong to daily washing field.Its raw materials by weight component includes：Side chain alcohol ether glucoside 3.0 8.0%, C1618APG 1.0 3.0%, citrate 1.0 5.0%, Cocoamidopropyl betaine 1.0 3.0%, AEO (9) 1.0 5.0%, glycerine 1.0 3.0%, bactericide 0.1 1.0%, appropriate essence and pigment, remaining is deionized water.The liquid energy deep-pollution-removing of washing one's hands, foam is fine and smooth, and feel is soft and moist, good with skin-friendliness, has effects that certain skin-moisturizing, skin.
Description
Technical field
The invention belongs to daily-use chemical industry technical field, and in particular to a kind of hand cleanser containing glucosides and its derivative.
Background technology
The transformation of mass consumption idea makes hand cleanser be increasingly becoming the substitute of traditional hand-washing article, extensive use in recent years
In public arenas such as family, hotel, restaurant, airport, station and hospitals.Hand cleanser uses bottle pump head squash type taken amount, it is to avoid
The solids such as perfumed soap, soap become easily infected by dirt on hand and the defect of bacterium, reduce the possibility of cross-infection.So
And, part hand sanitizer formula makes skin hair shaft astringent due to surfactant improper use, and skin is damaged.In addition, passing
The active matter such as ether alcohol sulfate AES that system hand sanitizer formula is generally used contains dioxane, alkanolamide 6501 and contains nitrosamine
Etc. poisonous and harmful property impurity.
Publication No. CN102631295A, Application No. 201210088615.5 is entitled containing glucosides and its derivative
The Chinese patent application of multifunctional foam hand cleanser and preparation method thereof, that application discloses a kind of containing glucosides and its derivative
Multifunctional foam hand cleanser, its percentage by weight being formulated, which is constituted, is：Citrate 6.0-9.0%, APG or alcohol ether sugar
Glycosides 1.0-3.0%, Coconut Fatty Acid Monoethanolamide (CMEA) 0.5-1.5%, bactericide 0.1-1.0%, essence 0-0.4%, pigment
0-0.001%, deionized water surplus.The formula is foam liquid soap, needs special pump head just to get foam when using.This
Application is slightly worse compared to the formula detergency and preserving moisture and protecting skin.
Publication No. CN101711726A, Application No. 200910199044.0, a kind of entitled ginseng skin-whitening liquid soap
And preparation method thereof Chinese patent application, washed one's hands that application discloses a kind of multifunctional foam containing glucosides and its derivative
Liquid, the hand cleanser by sodium sulfate of polyethenoxy ether of fatty alcohol, alkyl polyglucoside, Cocoamidopropyl betaine, glycerine,
The chloro- 2- hydroxy-diphenylethers of EDTA-2Na, MIT, 2,2,4- tri-, spices, pigment, citric acid, people
The raw materials such as ginseng saponin, distilled water are made.The formula uses sodium sulfate of polyethenoxy ether of fatty alcohol so that it has certain to skin
Excitant, mildness and detergency are slightly worse in comparison with the present application.
The content of the invention
It is an object of the invention to provide a kind of hand cleanser containing glucosides and its derivative.
Another object of the present invention is to provide a kind of preparation method containing glucosides and its derivative hand cleanser.
It is an object of the invention to prepare to wash one's hands to human body and environment all safe milds by main body of green active matter
Liquid, and its preparation method is provided.Active matter used is low to stimulate, moderate performance and nontoxic, good with skin-friendliness, with certain
Effect of skin-moisturizing, skin.
The present invention is realized by following technology：
A kind of hand cleanser containing glucosides and its derivative, is prepared from by following raw material by its percentage by weight：
Side chain alcohol ether glucoside is the compound with below formula in foregoing invention：
In formula：R1It is C4-C8Alkyl, R2It is C1-C4Alkyl, m is about 1.3.
C in foregoing invention1618APG is the compound with below formula：
In formula：R is C16-C18Alkyl, m be 1.1~1.3.
Citrate is fatty alcohol ether citrate, APG citrate, alcohol ether glucoside citric acid in foregoing invention
Ester etc., is the compound with below formula：
In formula：R3The alkyl for being 8~18 for carbon number, is 0 when m is 0 or 1.2~1.8, n are 0~9, m different with n.
Wherein：It is fatty alcohol ether citrate when 0, n is 1~9 that m, which is,；
M is that 1.2~1.8, n is alcohol ether glucoside citrate when being 1~9；
M is that 1.2~1.8, n is APG citrate when being 0.
Bactericide is poly hexamethylene biguanide (hydrochloride), dodine etc. in foregoing invention.
Wherein the molecular formula of bactericide poly hexamethylene biguanide is (C8H18N5Cl)14, molecular weight is 3080 (gel infiltration colors
Spectrometry).
Wherein side chain alcohol ether glucoside is the condensation product of branched fatty alcohol APEO and glucose sugar, and preparation method is referred to
Document：The preparation of Zhang Yuanjun, Yang Xiu congruence alcohol ether glucosides and its research chemical research of compound property and application, 2009,21
(8):1108-1112.
C1618APG is C1618The condensation product of natural fatty alcohol and glucose sugar.
Wherein AEO (9) refers to the AEO that oxirane adduction number is 9.
A kind of hand cleanser containing glucosides and derivative, preparation method is as follows：
The raw material presses its percentage by weight, and citrate and the 70-80% of deionized water gross weight are added into material kettle, stirred
Mix lower addition NaOH and be neutralized to pH for 6.0-7.0, then addition side chain alcohol ether glucoside, C at 70-80 DEG C1618APG, cocounut oil
Amido propyl betaine, AEO (9) and glycerine, stirring are cooled to 30-40 after the raw material is well mixed
DEG C, bactericide and balance deionized water are added, tune pH is 6.5-7.0, and appropriate pigment, essence can be added after stirring and is produced
To the hand cleanser.
The present invention has the advantage that compared with prior art：
1st, liquid energy deep-pollution-removing of washing one's hands of the invention, feel is soft and moist, and foam is fine and smooth, easily rinses.
2nd, hand cleanser of the invention selects nontoxic and performance temperature surfactant, good with skin-friendliness, with certain
Effect of skin-moisturizing, skin.
3rd, hand cleanser of the invention is nontoxic, non-stimulated, safe to the human body, environment-friendly.
The formula of the present invention is without using sodium sulfate of polyethenoxy ether of fatty alcohol, using non-stimulated alcohol ether glucoside and citric acid
Esters surface active agent, makes formula milder, and foam is fine and smooth, has effects that skin-moisturizing, skin, can prevent skin from cracking from dryness.
Embodiment
The present invention is described further below in conjunction with specific embodiment, these embodiments be merely to illustrate the present invention without
For limiting the scope of the present invention.
Embodiment 1
A kind of hand cleanser containing glucosides and derivative, its components in weight percent：
Embodiment 2
A kind of hand cleanser containing glucosides and derivative, its components in weight percent：
Embodiment 3
A kind of hand cleanser containing glucosides and derivative, its components in weight percent：
Embodiment 4
A kind of hand cleanser containing glucosides and derivative, its components in weight percent：
Embodiment 5
A kind of hand cleanser containing glucosides and derivative, its components in weight percent：
Embodiment 6
A kind of hand cleanser containing glucosides and derivative, its components in weight percent：
Embodiment 7
Formula as described in embodiment 1, adds material kettle, stirring is lower to be added by the 70% of citrate and deionized water gross weight
Enter NaOH and be neutralized to PH for 6.0-7.0, then at 70 DEG C plus side chain alcohol ether glucoside, C1618APG, cocamidopropyl propyl amide sweet tea
Dish alkali, AEO (9) and glycerine, stirring are cooled to 30 DEG C after the raw material is well mixed, add sterilization
Agent and balance deionized water, adjust PH be
6.5-7.0, can add appropriate pigment, essence and obtain the hand cleanser after stirring.
Embodiment 8
Formula as described in embodiment 2, preparation method be the same as Example 7.
Embodiment 9
Formula as described in embodiment 3, preparation method be the same as Example 7.
Embodiment 10
Formula as described in embodiment 4, preparation method be the same as Example 7.
Embodiment 11
Formula as described in embodiment 5, preparation method be the same as Example 7.
Embodiment 12
Formula as described in embodiment 6, preparation method be the same as Example 7.
Above example 1-12 hand cleanser detects that outward appearance is not stratified, without bright according to QB/T 2654-2013 regulation
Aobvious suspension or precipitation, without obvious mechanical admixture.Smell：Free from extraneous odour, meets regulation odor type.Gross activity thing content is all higher than
12%, meet the standard more than 7%.PH is 6.5-7.0, meets 4.0-10.0 as defined in standard, other physical and chemical indexs and micro- life
Thing index meets the requirements of the standard.
Comparative example
The formula and preparation method of comparative example see the table below 1.
Each comparative example formula of table 1 and preparation method
Test example
To above example 7-12 and comparative example 1-4 hand cleanser, each 10 people of men and women is smeared with mixed edible oil contaminants
The palm of the hand, the back of the hand carry out decontamination test, and continuous experiment 5 days is tested 3 times, 300 times altogether, the trial effect of feedback is such as each person every day
Table 2 below：
The embodiment 7-12 of table 2 and comparative example 1-4 hand cleanser decontamination test data
To above example 7-12 and comparative example 1-4 hand cleanser, foam and skin-moisturizing, skin performance test are carried out.
The measure of foaming properties：1/400mol/L liquor of washing one's hands is prepared with 500ml volumetric flasks, its solution 80ml is taken,
20ml running water is added, above-mentioned solution 50ml is added in 250ml tool plug graduated cylinders, clogs graduated cylinder mouthful and fluctuate three times, remember
Record foam height.
Skin-moisturizing, skin performance test：Each 10 people of men and women, continuous experiment 5 days is tested 3 times for each person every day, and the palm of the hand, the back of the hand are carried out
Test, 300 times altogether, the trial effect such as table 3 below of feedback：
The embodiment 7-12 of table 3 and comparative example 1-4 hand cleanser foam and skin-moisturizing, skin performance data
From above trial effect, due to using sodium sulfate of polyethenoxy ether of fatty alcohol in comparative example 1, and embodiment 7-
A certain amount of AEO and citrate are added in 12 so that embodiment 7-12 detergency, feel and moisturizing
Emollient is better than comparative example 1.Without using Cocoamidopropyl betaine, AEO (9) and sweet in comparative example 2
Oil, compared to embodiment, clean effect, foam and skin-moisturizing, skin are poor.Cocoamidopropyl betaine and fat in comparative example 3
The ratio of fat alcohol APEO (9) is increased compared with embodiment so that the feel and skin-moisturizing, skin of formula are poor.In comparative example 4
Without using side chain alcohol ether glucoside and C1618APG, its feel and foam decline compared with embodiment 7, and skin-moisturizing, skin is poor.
The preferred embodiment to the invention is illustrated above, but the invention be not limited to it is described
Embodiment, those skilled in the art can also make a variety of equivalent on the premise of without prejudice to the invention spirit
Modification or replacement, these equivalent modifications or replacement are all contained in the application claim limited range.
Claims (3)
1. a kind of hand cleanser containing glucosides and its derivative, is made up of following raw material by its percentage by weight：
The side chain alcohol ether glucoside is the compound with below formula：
In formula：R1It is C4-C8Alkyl, R2It is C1-C4Alkyl, m is 1.3；
The C1618APG is the compound with below formula：
In formula：R is C16-C18Alkyl, m be 1.1~1.3；
Above-mentioned citrate is fatty alcohol ether citrate, APG citrate or alcohol ether glucoside citrate, is to have
The compound of below formula：
In formula：R3The alkyl for being 8~18 for carbon number, is 0 when m is 0 or 1.2~1.8, n are 0~9, m different with n；
Wherein：It is fatty alcohol ether citrate when 0, n is 1~9 that m, which is,；
M is that 1.2~1.8, n is alcohol ether glucoside citrate when being 1~9；
M is that 1.2~1.8, n is APG citrate when being 0.
2. a kind of hand cleanser containing glucosides and its derivative according to claim 1, it is characterised in that the bactericide is
Poly hexamethylene biguanide or dodine.
3. the preparation method of the hand cleanser containing glucosides and its derivative described in claim 1 or 2, it is characterised in that including as follows
Step：
Raw material is pressed into above-mentioned formulation ratio, citrate and the 70-80% of deionized water gross weight are added into material kettle, stirring is lower to be added
Enter NaOH and be neutralized to pH for 6.0-7.0, then addition side chain alcohol ether glucoside, C at 70-80 DEG C1618APG, coconut oleoyl amine third
Base glycine betaine, AEO (9) and glycerine, stirring are cooled to 30-40 DEG C after the raw material is well mixed, then add
Enter bactericide and balance deionized water, tune pH is 6.5-7.0, is stirring evenly and then adding into pigment, essence and obtains the hand cleanser.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410631140.9A CN104434556B (en) | 2014-11-11 | 2014-11-11 | A kind of hand cleanser containing glucosides and its derivative |
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| CN201410631140.9A CN104434556B (en) | 2014-11-11 | 2014-11-11 | A kind of hand cleanser containing glucosides and its derivative |
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| CN104434556A CN104434556A (en) | 2015-03-25 |
| CN104434556B true CN104434556B (en) | 2017-10-03 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668422A (en) * | 1985-05-31 | 1987-05-26 | A. E. Staley Manufacturing Company | Liquid hand-soap or bubble bath composition |
| CN1651129A (en) * | 2004-11-30 | 2005-08-10 | 中国日用化学工业研究院 | Surface active agent alcohol ether glucoside and its preparation method |
| CN102631295A (en) * | 2012-03-30 | 2012-08-15 | 中国日用化学工业研究院 | Multifunctional foam liquid soap containing glucoside and derivatives of glucoside, and preparation method thereof |
| CN103666843A (en) * | 2013-12-20 | 2014-03-26 | 海安县吉程机械有限公司 | High-efficiency mechanical surface oil stain cleaning agent |
-
2014
- 2014-11-11 CN CN201410631140.9A patent/CN104434556B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668422A (en) * | 1985-05-31 | 1987-05-26 | A. E. Staley Manufacturing Company | Liquid hand-soap or bubble bath composition |
| CN1651129A (en) * | 2004-11-30 | 2005-08-10 | 中国日用化学工业研究院 | Surface active agent alcohol ether glucoside and its preparation method |
| CN102631295A (en) * | 2012-03-30 | 2012-08-15 | 中国日用化学工业研究院 | Multifunctional foam liquid soap containing glucoside and derivatives of glucoside, and preparation method thereof |
| CN103666843A (en) * | 2013-12-20 | 2014-03-26 | 海安县吉程机械有限公司 | High-efficiency mechanical surface oil stain cleaning agent |
Non-Patent Citations (1)
| Title |
|---|
| 日化用表面活性剂的研究与发展;方银军等;《中国洗涤用品工业》;20130228(第2013年2期);41-48 * |
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Effective date of registration: 20170704 Address after: 226600 fine chemical industry park, Haian economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU WAN QI BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: 201706, room 15, building 518, 407 East New District Road, Guzhen District, Shanghai, Qingpu Applicant before: SHANGHAI WANQI BIOTECHNOLOGY Co.,Ltd. |
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Address after: 226600 Nanhai Avenue 268, Haian City, Nantong City, Jiangsu Province Patentee after: JIANGSU WANQI BIOTECHNOLOGY Co.,Ltd. Address before: 226600 fine chemical industry park, Haian economic and Technological Development Zone, Jiangsu Patentee before: JIANGSU WAN QI BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A hand sanitizer containing glycosides and their derivatives Effective date of registration: 20230601 Granted publication date: 20171003 Pledgee: Haian Xinyuan rural small loan Co.,Ltd. Pledgor: JIANGSU WANQI BIOTECHNOLOGY Co.,Ltd. Registration number: Y2023980042395 |
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