CN104431362A - Feed additive capable of improving oxidative stress of dairy cows and application method of feed additive - Google Patents
Feed additive capable of improving oxidative stress of dairy cows and application method of feed additive Download PDFInfo
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- CN104431362A CN104431362A CN201410743399.2A CN201410743399A CN104431362A CN 104431362 A CN104431362 A CN 104431362A CN 201410743399 A CN201410743399 A CN 201410743399A CN 104431362 A CN104431362 A CN 104431362A
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Abstract
The invention discloses a feed additive capable of improving oxidative stress of dairy cows and an application method of the feed additive. The feed additive is prepared from three plant extracts, two reductive vitamins and a carrier. Compared with a common dairy cow feed additive and a breast health medicine, the feed additive has a brand-new effect; the oxidative stress, caused by various stress sources, of the dairy cows can be resisted, and free radicals in a body are eliminated; and breast tissues are prevented from oxidative damages, the milk yield of the dairy cows is improved and the milk quality is improved.
Description
Technical field:
The invention belongs to feed additive field, be specifically related to one and can remove milk cow interior free yl and resist oxidative damage, improve milk cow suffer feed addictive and the application of oxidative stress.
Background technology:
Milk cow is easy to suffer oxidative stress due to high strength metabolism, the lactation period of such as milk cow reaches 300 days, every day all will secrete a large amount of milk, metabolism and oxygen demand are all in very high level, add environment stress with the interpolation of lipid in daily ration, milk cow is made to be in oxidative stress status for a long time, on its health and production capacity, all there is negative impact, especially mammary gland is as conventional Functional tissue, oxidative damage is more serious, have and report that the incidence of disease of oxidative stress and mastitis for milk cows is interrelated, and directly results in the decline of lactation amount.Tradition milk cow health and breast protection exempt to take as the leading factor with antibacterial increasing, ignore the harm of oxidative stress to Breast health to a certain extent, the Main Means of effective prevention oxidative stress is to Cow-feeding antioxidant, but domesticly at present also directly the medicine of anti-oxidant intervention is not carried out to milk cow or feed addictive appears on the market, therefore the applicant is increasing with regard to the demand of existing market to this series products, develop a kind of high-efficiency antioxidant preparation of brand-new component, can prevent or alleviate the oxidative stress suffered by milk cow, correct the oxidative stress of milk cow, protection mammary gland is from oxidative damage, and improve lactation amount.The root of kudzu vine, buckwheat leaf, Radix Glycyrrhizae have significant effect because being rich in Flavonoid substances in anti-oxidation stress application, contained by three Plants, Flavonoid substances is different, the main isoflavone-containing of the root of kudzu vine, buckwheat leaf mainly mainly contains flavanone containing rutin, Radix Glycyrrhizae, the group of onset and also have respective characteristic to the specificity of free radical, therefore composition has synergy and the effect comprehensively of anti-oxidation stress, and effect is more definite than the application of single Chinese herbal medicine.Vitamin E and vitamin A all have stronger reproducibility, play antioxidation by direct scavenging free radicals or the activity strengthening antioxidant system, and the deficiency of polyphenoils in supplement feed.
Summary of the invention:
The object of the present invention is to provide a kind of feed addictive and the application process thereof that improve milk cow oxidative stress, this additive can eliminate the excessive free radicals produced in Contents in Cows, avoid cow mammary gland tissue oxidizing damage, dairy products quality can be improved especially and improve milk production of cow.
Improve a feed addictive for milk cow oxidative stress, described additive is made up of the component of following weight portion: compound kudzu root extract 4-8 part, vitamin A 4.4-8.8 part, vitamin E 1-2.5 part, ditert-butylhydro quinone 0.5-1 part, sepiolite 500-700 part, system chaff 300-400 part.
Described additive is made up of the component of following weight portion: compound kudzu root extract 6 parts, vitamin A 6.6 parts, vitamin e1 .5 part, ditert-butylhydro quinone 0.5 part, sepiolite 600 parts, system chaff 400 parts.
Described additive is made up of the component of following weight portion: compound kudzu root extract 8 parts, vitamin A 8.8 parts, vitamin E2 .5 part, ditert-butylhydro quinone 1 part, sepiolite 700 parts, system chaff 300 parts.
Described compound kudzu root extract is by the root of kudzu vine of 40-60 weight portion, and the buckwheat leaf of 20-40 weight portion, the mixture of the Radix Glycyrrhizae composition of 10-30 weight portion forms after concentrating through pulverizing, alcohol extracting, filtration, filtrate.
The mass ratio that the above-mentioned concentrated extract obtained accounts for former medicine is 1%-2%.
60 mesh sieves are crossed after pulverizing in said extracted thing preparation process.By the ethanol of the screenings 60%-80% after pulverizing and sieving at 25-35 DEG C of refluxing extraction 2-4 hour, filter.Filtrate is concentrate drying at 40-50 DEG C.
Described feed addictive is applied to the additive that preparation improves milk cow oxidative stress.It is 50-80g/ head that every day adds described feed addictive addition in milk cow TMR daily ration.
Feed addictive manufacturing process of the present invention:
Premixed: by compound kudzu root extract and sepiolite premixed, two kinds of vitamins and the premixed of system chaff,
Mixing: two kinds of premixs are added Homogeneous phase mixing after antioxidant ditert-butylhydro quinone.
Key of the present invention is to provide a kind of brand-new breast health-care and anti-oxidant intervention to milk cow, and analyzes and the actual effect of testing and verification in milk cow anti-oxidation stress.Important effect is played to prevention milk cow oxidative damage, the reduction mammitis incidence of disease, raising breast tissue health degree and Milk Production.
Detailed description of the invention:
Following embodiment is intended to further illustrate the present invention, instead of limitation of the present invention.
Embodiment 1
1, take the root of kudzu vine 50 parts, buckwheat leaf 30 parts, 20 parts, Radix Glycyrrhizae, pulverize after mixing, cross 60 mesh sieves, extract 3 hours with 70% alcohol reflux, filter, filtrate obtains compound kudzu root extract at 45 DEG C of concentrate dryings, and extract accounts for the 1%-2% of former medicine.
2, premix conjunction 6g compound kudzu root extract mixes with 600g sepiolite; Get 6.6g vitamin A, 1.5g vitamin E and 400g chaff of uniting mixes.
3, mix above two kinds of premixs are added 0.5g ditert-butylhydro quinone after again stir make to mix.
4, by lab technician to mixture homogeneity, active principle content, moisture, loading amount all index detect.
5, packaging warehouse-in.
Embodiment 2
1, take the root of kudzu vine 60 parts, buckwheat leaf 25 parts, 15 parts, Radix Glycyrrhizae, pulverize after mixing, cross 60 mesh sieves, extract 2.5 hours with 80% alcohol reflux, filter, filtrate obtains compound kudzu root extract at 45 DEG C of concentrate dryings, and extract accounts for the 1%-2% of former medicine.
2, premix conjunction 8g compound kudzu root extract mixes with 700g sepiolite; Get 8.8g vitamin A, 2.5g vitamin E and 300g chaff of uniting mixes.
3, mix above two kinds of premixs are added 1g ditert-butylhydro quinone after again stir make to mix.
4, by lab technician to mixture homogeneity, active principle content, moisture, loading amount all index detect.
5, packaging warehouse-in.
Embodiment 3
The comparative studies of antioxidation activity in body
1, materials and methods
Choose body weight, calving age in days, china holstein cows 40 that the output of milk is close with parity, be divided into 4 groups at random, control group fed basal diet, under the same terms, test 1 group in basal diet, add vitamin e1 00mg/ day/head, test 2 groups and add daizeol 400mg/ day/head, test 3 groups of additive 50g/ day/head adding the embodiment of the present invention 1 and prepare, experimental period is 20 days, collect milk sample by head 2 times before and after test, detect wherein superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and MDA value with kit.
2, result of the test
As shown in Table 1, every this test of Antioxidant Indexes additive group more all has pole significant difference (P < 0.01) with control group, and vitamin E group and daizeol group to compare with control group be significant difference (P < 0.05), prove that the antioxidant effect of feed addictive of the present invention to cow mammary gland is better than vitamin E and daizeol, there is oxidation resistant synergy.
Table 1: feed addictive of the present invention compares with the antioxidant effect of other antioxidant in Contents in Cows
Note: result of the test mean value ± standard error represents, in test card, each data shoulder mark capitalization difference then represents that two groups of numeric ratios comparatively have pole significant difference (P < 0.01), shoulder mark capitalization identical person represents that two groups of data compare and have significant difference (P < 0.05), and the identical person of shoulder mark lowercase represents two groups of data comparing differences significantly (P > 0.05).
Embodiment 4
The improvement of clinical and milk performance healthy for cow mammary gland
1, materials and methods
A cattle farm to be in same lactation stage milking cow totally 90 be divided into 2 groups at random, often organize 45, under identical management and rearing conditions, test group milk cow adds the embodiment of the present invention 2 additive 50g/ day/head in TMR daily ration, continuous use 20 days, record the output of milk of single milk cow every day, in test front and back are to milk, somatic number detects, and observes and records duration of test mastitis for milk cows incidence.
2, result of the test
2.1 pairs of cow breast health-care effects
Table 2: the change (ten thousand/ml) of somatic number in milk
| Minute | Control group | Additive group of the present invention | Breast scorching morbidity head number | The scorching incidence of disease of breast |
| Before test | 43.63 a | 45.72 a | 5 | 11.1％ |
| After test | 44.59 a | 28.04 B | 1 | 2.2％ |
As seen from the above table, use feed addictive of the present invention can effectively reduce somatic cell count in milk, control the incidence of disease of mammitis, to cow mammary gland, there is significant health-care efficacy.
2.2 pairs of dairy cattles improve effect
Table 3: antioxidant is on the impact (kg/ day/head) of Lactation of Dairy Cow amount
| Group | Before test | After test |
| Control group | 22.13±1.44 a | 21.75±1.28 a |
| Additive group of the present invention | 21.56±1.25 a | 22.84±1.19 A |
As seen from the above table, the application of the invention additive, Lactation of Dairy Cow amount improves relatively, compares, increasing degree 5.94% with before test, detects and has significant difference (P < 0.05).
Claims (10)
1. one kind is improved the feed addictive of milk cow oxidative stress, it is characterized in that, described additive is made up of the component of following weight portion: compound kudzu root extract 4-8 part, vitamin A 4.4-8.8 part, vitamin e1-2.5 parts, ditert-butylhydro quinone 0.5-1 part, sepiolite 500-700 part, system chaff 300-400 part.
2. the feed addictive of described improvement milk cow oxidative stress is required according to right 1, it is characterized in that, described feed addictive is made up of the component of following weight portion: compound kudzu root extract 6 parts, vitamin A 6.6 parts, vitamin e1 .5 part, ditert-butylhydro quinone 0.5 part, sepiolite 600 parts, system chaff 400 parts.
3. the feed addictive of described improvement milk cow oxidative stress is required according to right 1, it is characterized in that, described feed addictive is made up of the component of following weight portion: compound kudzu root extract 8 parts, vitamin A 8.8 parts, vitamin E2 .5 part, ditert-butylhydro quinone 1 part, sepiolite 700 parts, system chaff 300 parts.
4. the feed addictive improving milk cow oxidative stress according to claim 1, it is characterized in that, the mixture that described compound kudzu root extract is made up of the Radix Glycyrrhizae of the root of kudzu vine of 40-60 weight portion, the buckwheat leaf of 20-40 weight portion and 10-30 weight portion forms after concentrating through pulverizing, alcohol extracting, filtration, filtrate.
5. the feed addictive improving milk cow oxidative stress according to claim 4, is characterized in that, the mass ratio that the concentrated extract obtained accounts for former medicine is 1%-2%.
6. the feed addictive improving milk cow oxidative stress according to claim 4, is characterized in that, crosses 60 mesh sieves after pulverizing.
7. the feed addictive improving milk cow oxidative stress according to claim 4, is characterized in that, by the ethanol of the screenings 60%-80% after pulverizing and sieving at 25-35 DEG C of refluxing extraction 2-4 hour, filters.
8. the feed addictive improving milk cow oxidative stress according to claim 4, is characterized in that, filtrate is concentrate drying at 40-50 DEG C.
9. the application process of the improvement milk cow oxidative stress feed addictive described in any one of claim 1-8, is characterized in that, described feed addictive is applied to the additive that preparation improves milk cow oxidative stress.
10. the application process improving the feed addictive of milk cow oxidative stress according to claim 9, is characterized in that, the addition adding described feed addictive every day in milk cow forage is 50-80g/ head.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410743399.2A CN104431362B (en) | 2014-12-08 | 2014-12-08 | It is a kind of to improve the feed addictive and its application process of milk cow oxidative stress |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410743399.2A CN104431362B (en) | 2014-12-08 | 2014-12-08 | It is a kind of to improve the feed addictive and its application process of milk cow oxidative stress |
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| CN104431362A true CN104431362A (en) | 2015-03-25 |
| CN104431362B CN104431362B (en) | 2017-09-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108244353A (en) * | 2016-12-28 | 2018-07-06 | 上海交通大学 | For promoting the feed addictive of breeding sheep redox equilibrium and its application |
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| CN104431362B (en) | 2017-09-19 |
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