CN104413328A - Immunity enhancing health product - Google Patents
Immunity enhancing health product Download PDFInfo
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- CN104413328A CN104413328A CN201310368106.2A CN201310368106A CN104413328A CN 104413328 A CN104413328 A CN 104413328A CN 201310368106 A CN201310368106 A CN 201310368106A CN 104413328 A CN104413328 A CN 104413328A
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- chondroitin sulfate
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- health products
- health
- enzymolysis
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- 230000036541 health Effects 0.000 title claims abstract description 21
- 230000036039 immunity Effects 0.000 title claims abstract description 15
- 230000002708 enhancing effect Effects 0.000 title abstract 4
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 29
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 29
- 210000000845 cartilage Anatomy 0.000 claims abstract description 13
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 12
- 229920001661 Chitosan Polymers 0.000 claims abstract description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 7
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 6
- 235000009508 confectionery Nutrition 0.000 claims abstract description 6
- 239000008103 glucose Substances 0.000 claims abstract description 6
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 6
- 239000011718 vitamin C Substances 0.000 claims abstract description 6
- 239000000047 product Substances 0.000 claims description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 15
- 241001465754 Metazoa Species 0.000 claims description 11
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 239000003480 eluent Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 229940088598 enzyme Drugs 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 238000005904 alkaline hydrolysis reaction Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 5
- 108010019160 Pancreatin Proteins 0.000 claims description 5
- 108090000526 Papain Proteins 0.000 claims description 5
- 239000004365 Protease Substances 0.000 claims description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
- 150000001875 compounds Chemical group 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000003337 fertilizer Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000009413 insulation Methods 0.000 claims description 5
- 239000003456 ion exchange resin Substances 0.000 claims description 5
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229940055695 pancreatin Drugs 0.000 claims description 5
- 229940055729 papain Drugs 0.000 claims description 5
- 235000019834 papain Nutrition 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000007974 sodium acetate buffer Substances 0.000 claims description 5
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 5
- 238000001179 sorption measurement Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 229920002567 Chondroitin Polymers 0.000 claims description 4
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- 238000010306 acid treatment Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000001117 sulphuric acid Substances 0.000 claims description 2
- 235000011149 sulphuric acid Nutrition 0.000 claims description 2
- 235000013402 health food Nutrition 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 5
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000004321 preservation Methods 0.000 abstract description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 description 4
- 229920002683 Glycosaminoglycan Polymers 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 208000033065 inborn errors of immunity Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 description 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 description 1
- 206010057178 Osteoarthropathies Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000486406 Trachea Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses an immunity enhancing health product. The immunity enhancing health product comprises, by weight, 15-20 parts of 4-6% chondroitin sulfate, 10-15 parts of mannitol, 6-8 parts of vitamin C, 20-30 parts of glucose, 5-8 parts of D-glucosamine hydrochloride, 4-6 parts of a chitosan solution, and 10-20 parts of isomaltooligosacharide. The above health food is sweet and tasty, chondroitin sulfate and D-glucosamine hydrochloride have a joint cartilage strengthening effect, and chitosan has stomach protecting and nourishing effects, so the obtained health product has a good immunity enhancing efficacy. The health food is granular; and compared with previous health foods, the health food has the advantages of carrying and preservation convenience and no deterioration.
Description
Technical field
The invention belongs to field of health care food, be specifically related to a kind of health products improving immunity.
Background technology
Chondroitin sulfate is the acidic mucopolysaccharide extracting from cartilages such as mammal tracheaes and obtain.White powder, odorless, tasteless, easy moisture absorption, soluble in water, be insoluble to ethanol and acetone and other organic solvent, namely chance water expand or become and stick slurry, more unstable to heat.Need lucifuge to seal to preserve.The glutinous polysaccharide that chondroitin is made up of D-Glucose aldehydic acid and N-acetyl-D-galactosamine.Chondroitin sulfate is the sulfuric ester of chondroitin, forms the main component of connective tissue.It has clarification lipid, improves body function of detoxification, the effect such as diuresis and analgesia.Very effective to Collagen illness, also effective to the dysacousis caused by streptomysin.Acidic mucopolysaccharide is one of endemic element in connective tissue matrix in organism, and chondroitin sulfate A (CSA) is the one of acidic mucopolysaccharide.Medically prevent and treat for coronary heart disease.
The more method of domestic use be adopt diluted alkaline or concentrated base to combine with enzymolysis method to extract chondroitin sulfate, this alkaline process enzymolysis production process is adopted to there is complex steps, cycle longer, generally need 3-5 days, product quality and yield instability, in thermophilic digestion, alkali extraction, enzymolysis and decolorization, chondroitin sulfate is subject to heavy damage, and product yield is on the low side, solution colour is deepened, alcohol consumption quantity is large, and production cost is high.
Along with increasing of age, osteoarthropathy, hypoimmunity have become international a difficult problem.Osteoarthrosis is also known as hypertrophiarthritis or degenerative arthritis, and main manifestations is that bone amount reduces, and bone fragility increases, the clinical symptoms such as concurrent back pain, and very easily fracture disables, and has a strong impact on the quality of life of people.If patients with osteoporosis is simultaneously with hypoimmunity, situation is just more serious.So exploitation has the health care increasing bone density, develop immunitypty, the health food that can effectively prevent osteoporosis from occurring has become a kind of active demand of society.
Health food has the general character of normal food, can regulate the function of human body, is suitable for specific crowd and eats, but can not disease therapy.Health (functional) food is called as " healthy food " in European and American countries, is called as " functional food " in Japan.Health food not only need human body and zoopery to prove this product has a certain physiological regulation function, more need to find out structure, content, the mechanism of action and the due stable form in food with this health factor.
How being used to animal cartilage, while production chondroitin sulfate, be combined with the raw material such as D-aminoglucose hydrochloride, chitosan solution, obtaining a kind of health products improving immunity, is the technical problem to be solved in the present invention.
Summary of the invention
The invention provides a kind of health products improving immunity, it is characterized in that, each component is composed as follows according to weight portion: chondroitin sulfate 15-20 part of 4-6%; Sweet mellow wine 10-15 part; Vitamin C 6-8 part; Glucose 20-30 part; D-aminoglucose hydrochloride 5-8 part; Chitosan solution 4-6 part; Oligoisomaltose 10-20 part.
Above-mentioned a kind of health products improving immunity, it is characterized in that, the preparation method of described chondroitin sulfate comprises the following steps:
A, pretreatment: get animal cartilage and be placed in digester and boil 25-35min, pull out and rinse with clear water, pulverize, weigh for subsequent use;
B, alkaline hydrolysis: the aqueous solution added by solid-liquid ratio 1:2 by pretreated animal cartilage, in sodium hydrate aqueous solution, adjust pH=8-9, control temperature 50-55 DEG C to carry out alkaline hydrolysis;
C, enzymolysis: add 6-8g/kg enzyme, control temperature is 38-55
oc, enzymolysis 4-6h, be warmed up to 90 DEG C of insulation 10-15min and go out enzyme;
D, acid treatment: in enzymolysis liquid, add watery hydrochloric acid or phosphoric acid adjustment pH value of solution=3.5-4.0, raised temperature is to 75-85
oc, heating 35-40min, places and filters, concentrated;
E, absorb-elute: through the continuous exchange adsorption of ion exchange resin after filtrate is concentrated, with the sodium-acetate buffer wash-out of pH=5-7, flow velocity 50-53mL/h, collects eluent;
F, Sulphuric acid chondroitin: the alcohol settling that eluent adds 1.5-2 times of volume after hydrogen peroxide for decoloration obtains chondroitin sulfate, centrifugal 15-18min, is placed in thermostatic drying chamber, temperature control 60
oc is dry, and 4h obtains sterling chondroitin sulfate;
Above-mentioned a kind of health products improving immunity, it is characterized in that, the enzyme added in described step b is compound fertilizer production, papain and pancreatin, adding proportion is 1:1:1 or 1:2:1 or 1:2:2.
Above-mentioned a kind of health products improving immunity, is characterized in that, these health products preparation method is: by the chondroitin sulfate of gained and other mixing of materials, stir, then make particle by comminutor, dry.
The beneficial effect of the invention:
Health food product sweetness of the present invention is tasty and refreshing, chondroitin sulfate and D-aminoglucose hydrochloride and chondroitin sulfate to the humidification of articular cartilage, be applicable to that hypoimmunity causes have a delicate constitution, the symptom such as fatigue and weak.Shitosan has and protects stomach, nourishing the stomach effect, and the personage being thus suitable for stomach cold and cool eats for a long time.Thus health food product of the present invention have effect of good develop immunitypty.Health food of the present invention is graininess, compares with health food in the past, has and carries convenient, the not perishable advantage of preservation.
Detailed description of the invention
Embodiment 1:
Get animal cartilage to be placed in digester and to boil 25min, pull out and rinse with clear water, pulverize, weigh for subsequent use; By the aqueous solution that pretreated animal cartilage adds by solid-liquid ratio 1:2, in sodium hydrate aqueous solution, adjust pH=8-9, control temperature 50 DEG C carries out alkaline hydrolysis; Add compound fertilizer production, papain and pancreatin that 6g/kg ratio is 1:1:1, control temperature is 38
oc, enzymolysis 4h, be warmed up to 90 DEG C of insulation 10min and go out enzyme; Watery hydrochloric acid or phosphoric acid adjustment pH value of solution=3.5-4.0 is added, raised temperature to 75 in enzymolysis liquid
oc, heating 35min, places and filters, concentrated; Through the continuous exchange adsorption of ion exchange resin after filtrate is concentrated, with the sodium-acetate buffer wash-out of pH=5-7, flow velocity 50mL/h, collects eluent; The alcohol settling that eluent adds 2 times of volumes after hydrogen peroxide for decoloration obtains chondroitin sulfate, and centrifugal 15min, is placed in thermostatic drying chamber, temperature control 60
oc is dry, and 4h obtains sterling chondroitin sulfate; The chondroitin sulfate of gained is adjusted to the solution of 4%; get 20 parts, 15 parts, sweet mellow wine, vitamin C 8 parts, glucose 25 parts, D-aminoglucose hydrochloride 8 parts, chitosan solution 4 parts, oligoisomaltose 20 parts mixing; stir, then make particle by comminutor, dry.
Embodiment 2:
Get animal cartilage to be placed in digester and to boil 30min, pull out and rinse with clear water, pulverize, weigh for subsequent use; By the aqueous solution that pretreated animal cartilage adds by solid-liquid ratio 1:2, in sodium hydrate aqueous solution, adjust pH=8-9, control temperature 50 DEG C carries out alkaline hydrolysis; Add compound fertilizer production, papain and pancreatin that 7g/kg ratio is 1:2:1, control temperature is 40
oc, enzymolysis 5h, be warmed up to 90 DEG C of insulation 15min and go out enzyme; Watery hydrochloric acid or phosphoric acid adjustment pH value of solution=3.5-4.0 is added, raised temperature to 80 in enzymolysis liquid
oc, heating 35min, places and filters, concentrated; Through the continuous exchange adsorption of ion exchange resin after filtrate is concentrated, with the sodium-acetate buffer wash-out of pH=5-7, flow velocity 52mL/h, collects eluent; The alcohol settling that eluent adds 2 times of volumes after hydrogen peroxide for decoloration obtains chondroitin sulfate, and centrifugal 18min, is placed in thermostatic drying chamber, temperature control 60
oc is dry, and 4h obtains sterling chondroitin sulfate; The chondroitin sulfate of gained is adjusted to the solution of 5%; get 20 parts, 15 parts, sweet mellow wine, vitamin C 8 parts, glucose 25 parts, D-aminoglucose hydrochloride 8 parts, chitosan solution 4 parts, oligoisomaltose 20 parts mixing; stir, then make particle by comminutor, dry.
Embodiment 3:
Get animal cartilage to be placed in digester and to boil 35min, pull out and rinse with clear water, pulverize, weigh for subsequent use; By the aqueous solution that pretreated animal cartilage adds by solid-liquid ratio 1:2, in sodium hydrate aqueous solution, adjust pH=8-9, control temperature 55 DEG C carries out alkaline hydrolysis; Add compound fertilizer production, papain and pancreatin that 8g/kg ratio is 1:2:2, control temperature is 50
oc, enzymolysis 4h, be warmed up to 90 DEG C of insulation 15min and go out enzyme; Watery hydrochloric acid or phosphoric acid adjustment pH value of solution=3.5-4.0 is added, raised temperature to 80 in enzymolysis liquid
oc, heating 40min, places and filters, concentrated; Through the continuous exchange adsorption of ion exchange resin after filtrate is concentrated, with the sodium-acetate buffer wash-out of pH=5-7, flow velocity 53mL/h, collects eluent; The alcohol settling that eluent adds 2 times of volumes after hydrogen peroxide for decoloration obtains chondroitin sulfate, and centrifugal 18min, is placed in thermostatic drying chamber, temperature control 60
oc is dry, and 4h obtains sterling chondroitin sulfate; The chondroitin sulfate of gained is adjusted to the solution of 6%; get 20 parts, 15 parts, sweet mellow wine, vitamin C 8 parts, glucose 25 parts, D-aminoglucose hydrochloride 8 parts, chitosan solution 4 parts, oligoisomaltose 20 parts mixing; stir, then make particle by comminutor, dry.
Claims (3)
1. improve health products for immunity, it is characterized in that, each component is composed as follows according to weight portion:
Chondroitin sulfate 15-20 part of 4-6%;
Sweet mellow wine 10-15 part;
Vitamin C 6-8 part;
Glucose 20-30 part;
D-aminoglucose hydrochloride 5-8 part;
Chitosan solution 4-6 part;
Oligoisomaltose 10-20 part.
2. a kind of health products improving immunity according to claim 1, it is characterized in that, the preparation method of described chondroitin sulfate comprises the following steps:
A, pretreatment: get animal cartilage and be placed in digester and boil 25-35min, pull out and rinse with clear water, pulverize, weigh for subsequent use;
B, alkaline hydrolysis: the aqueous solution added by solid-liquid ratio 1:2 by pretreated animal cartilage, in sodium hydrate aqueous solution, adjust pH=8-9, control temperature 50-55 DEG C to carry out alkaline hydrolysis;
C, enzymolysis: add 6-8g/kg enzyme, control temperature is 38-55
oc, enzymolysis 4-6h, be warmed up to 90 DEG C of insulation 10-15min and go out enzyme;
D, acid treatment: in enzymolysis liquid, add watery hydrochloric acid or phosphoric acid adjustment pH value of solution=3.5-4.0, raised temperature is to 75-85
oc, heating 35-40min, places and filters, concentrated;
E, absorb-elute: through the continuous exchange adsorption of ion exchange resin after filtrate is concentrated, with the sodium-acetate buffer wash-out of pH=5-7, flow velocity 50-53mL/h, collects eluent;
F, Sulphuric acid chondroitin: the alcohol settling that eluent adds 1.5-2 times of volume after hydrogen peroxide for decoloration obtains chondroitin sulfate, centrifugal 15-18min, is placed in thermostatic drying chamber, temperature control 60
oc is dry, and 4h obtains sterling chondroitin sulfate;
A kind of health products improving immunity according to claim 2, it is characterized in that, the enzyme added in described step b is compound fertilizer production, papain and pancreatin, adding proportion is 1:1:1 or 1:2:1 or 1:2:2.
3. a kind of health products improving immunity according to claim 1, is characterized in that, these health products preparation method is: by the chondroitin sulfate of gained and other mixing of materials, stir, then make particle by comminutor, dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310368106.2A CN104413328A (en) | 2013-08-22 | 2013-08-22 | Immunity enhancing health product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310368106.2A CN104413328A (en) | 2013-08-22 | 2013-08-22 | Immunity enhancing health product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104413328A true CN104413328A (en) | 2015-03-18 |
Family
ID=52964260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310368106.2A Pending CN104413328A (en) | 2013-08-22 | 2013-08-22 | Immunity enhancing health product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104413328A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104824511A (en) * | 2015-05-21 | 2015-08-12 | 张利民 | Prebiotics composition |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0167831B1 (en) * | 1995-08-07 | 1999-01-15 | 김선봉 | Process for preparing sea cucumber extract containing chondroitin sulfate |
| CN1423961A (en) * | 2002-12-26 | 2003-06-18 | 上海德生生物科技有限公司 | Chitin healthy food and production thereof |
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