CN104411699B - 苯基三唑衍生物及其用于调节gabaa 受体复合体的用途 - Google Patents
苯基三唑衍生物及其用于调节gabaa 受体复合体的用途 Download PDFInfo
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| PCT/EP2013/063193 WO2014001281A1 (en) | 2012-06-26 | 2013-06-25 | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
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| CN104411699A CN104411699A (zh) | 2015-03-11 |
| CN104411699B true CN104411699B (zh) | 2017-06-13 |
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| AU2015233686B2 (en) * | 2014-03-18 | 2019-07-11 | Algiax Pharmaceuticals Gmbh | 2-Cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives |
| BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
| HU231223B1 (hu) | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| EP3858965B1 (en) * | 2020-01-28 | 2022-05-11 | The Procter & Gamble Company | Cleaning product |
| WO2021191838A1 (en) * | 2020-03-26 | 2021-09-30 | Richter Gedeon Nyrt. | NAPHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA α5 RECEPTOR MODULATORS |
| EP4126858A1 (en) | 2020-03-26 | 2023-02-08 | Richter Gedeon Nyrt. | Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| EP3992188A1 (en) * | 2020-10-29 | 2022-05-04 | Boehringer Ingelheim International GmbH | Difluoromethyl-pyridin-2-yl triazoles |
| CN120943816A (zh) * | 2020-08-05 | 2025-11-14 | 勃林格殷格翰国际有限公司 | 二氟甲基-吡啶-2-基三唑 |
| EP4385988A4 (en) * | 2021-08-12 | 2025-11-05 | Shanghai Simr Biotechnology Co Ltd | Substituted triazole derivative, its preparation process, pharmaceutical composition thereof and associated use |
| EP4561444A1 (en) | 2022-07-29 | 2025-06-04 | F. Hoffmann-La Roche AG | Characterisation of neurological dysfunction |
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| WO1999032454A1 (en) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
| WO2012062687A1 (en) * | 2010-11-09 | 2012-05-18 | F. Hoffmann-La Roche Ag | Triazole derivatives and their use for neurological disorders |
| WO2012076590A1 (en) * | 2010-12-10 | 2012-06-14 | F. Hoffmann-La Roche Ag | Novel triazole compounds iii |
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| ES2314943T3 (es) | 2005-09-19 | 2009-03-16 | F. Hoffmann-La Roche Ag | Derivados de isoxazolo como agonistas inversos de gaba a alfa. |
| BRPI0617306A2 (pt) | 2005-10-11 | 2011-07-19 | Hoffmann La Roche | derivados de isoxazol |
| ES2341131T3 (es) | 2005-11-09 | 2010-06-15 | F.Hoffmann-La Roche Ag | Derivados de 3-aril-isoxazol-4-carbonil-benzofurano. |
| JP5015172B2 (ja) | 2005-12-23 | 2012-08-29 | エフ．ホフマン−ラ ロシュ アーゲー | アリール−イソオキサゾロ−４−イル−オキサジアゾール誘導体 |
| PT1968973E (pt) | 2005-12-27 | 2011-12-09 | Hoffmann La Roche | Derivados de aril-isoxazol-4-il-imidazol |
| CA2633536A1 (en) | 2005-12-27 | 2007-07-05 | F. Hoffmann-La Roche Ag | Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives |
| AU2007267183B2 (en) | 2006-05-31 | 2011-10-20 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
| EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
| EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
| ES2369805T3 (es) | 2007-06-22 | 2011-12-07 | F. Hoffmann-La Roche Ag | Derivados de isoxazol-imidazol. |
| KR20120102117A (ko) * | 2007-12-04 | 2012-09-17 | 에프. 호프만-라 로슈 아게 | 아이속사졸로-피리딘 유도체 |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| BRPI0820649A2 (pt) | 2007-12-04 | 2015-06-16 | Hoffmann La Roche | Derivados de isoxazalo-pirazina |
| EP2128158A1 (en) | 2008-05-26 | 2009-12-02 | Phenex Pharmaceuticals AG | Heterocyclic cyclopropyl-substituted FXR binding compounds |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| US8227461B2 (en) | 2009-04-30 | 2012-07-24 | Hoffmann-La Roche Inc. | Isoxazoles |
| US8410104B2 (en) | 2009-05-05 | 2013-04-02 | Hoffmann-La Roche Inc. | Pyridazines |
| CN102414208B (zh) | 2009-05-05 | 2014-11-05 | 霍夫曼-拉罗奇有限公司 | 作为用于认知性障碍的治疗中的gaba a受体逆激动剂的异*唑-噻唑衍生物 |
| JP5466292B2 (ja) | 2009-05-05 | 2014-04-09 | エフ．ホフマン−ラ ロシュ アーゲー | イソオキサゾール−ピリジン誘導体 |
| CA2760746C (en) | 2009-05-05 | 2017-07-11 | F. Hoffmann-La Roche Ag | Isoxazole-pyrazole derivatives |
| BRPI1013766A2 (pt) | 2009-05-07 | 2016-04-05 | Hoffmann La Roche | "derivados de isoxazol-piridina como moduladores de gaba" |
| EP2289883A1 (en) | 2009-08-19 | 2011-03-02 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| WO2012059482A1 (en) | 2010-11-05 | 2012-05-10 | F. Hoffmann-La Roche Ag | Use of active pharmaceutical compounds for the treatment of central nervous system conditions |
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2013
- 2013-06-25 JP JP2015519034A patent/JP6224097B2/ja not_active Expired - Fee Related
- 2013-06-25 AU AU2013283487A patent/AU2013283487C1/en not_active Ceased
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999032454A1 (en) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
| WO2012062687A1 (en) * | 2010-11-09 | 2012-05-18 | F. Hoffmann-La Roche Ag | Triazole derivatives and their use for neurological disorders |
| WO2012076590A1 (en) * | 2010-12-10 | 2012-06-14 | F. Hoffmann-La Roche Ag | Novel triazole compounds iii |
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| AU2013283487C1 (en) | 2018-01-18 |
| KR20150033678A (ko) | 2015-04-01 |
| IL236041A0 (en) | 2015-02-01 |
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| WO2014001281A1 (en) | 2014-01-03 |
| US9206160B2 (en) | 2015-12-08 |
| EP2877463A1 (en) | 2015-06-03 |
| US20160067234A1 (en) | 2016-03-10 |
| JP6224097B2 (ja) | 2017-11-01 |
| JP2015521642A (ja) | 2015-07-30 |
| CA2876778A1 (en) | 2014-01-03 |
| MX2014014871A (es) | 2015-06-17 |
| AU2013283487A1 (en) | 2015-01-22 |
| IL236041A (en) | 2016-09-29 |
| EP2877463B1 (en) | 2018-11-07 |
| US9931329B2 (en) | 2018-04-03 |
| AU2013283487B2 (en) | 2017-05-25 |
| MX357504B (es) | 2018-07-12 |
| CN104411699A (zh) | 2015-03-11 |
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